Floyd H. Chilton, Ph.D.Wake Forest School of Medicine

Floyd H. Chilton, Ph.D.


Contact Information

Academic: 336-716-4322 | Department: 336-713-7105


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Education & Training

  • B.S., Western Carolina University, 1980
  • Ph.D., Wake Forest University, 1984
  • Fellowship, University of Colorado School, 1986


  • Am Assn Of Advancement Of Scie
  • Am Assn Of Medical Colleges (B
  • Am Assn Of Thoracic Surgery
  • Am Soc Of Biochem & Mol Biolog
Floyd H. Chilton, Ph.D.

Floyd H. Chilton, Ph.D.

Professor, Physiology & Pharmacology

Research Interests

atherosclerosis/thrombosis, biotechnology, cross(mult/tnslat/inter)discip, genetics/genome, growth & development, immunology/allergy/inflammatio, maternal & child health, metabolism, molecular biology/molecular me, nutrition, prevention

Contact Information

Academic: 336-716-4322 | Department: 336-713-7105


Media Medical Expert »

Related Links

Recent Publications

Miller LR, Jorgensen MJ, Kaplan JR, Seeds MC, Rahbar E, Morgan TM, Welborn A, Chilton SM, Gillis J, Hester A, Rukstalis M, Sergeant S, Chilton FH. Alterations in levels and ratios of n-3 and n-6 polyunsaturated fatty acids in the temporal cortex and liver of vervet monkeys from birth to early adulthood. Physiol Behav. 2016;156():71-78.

Sergeant S, Ruczinski I, Ivester P, Lee TC, Morgan TM, Nicklas BJ, Mathias RA, Chilton FH. Impact of methods used to express levels of circulating fatty acids on the degree and direction of associations with blood lipids in humans. Br J Nutr. 2016;115(2):251-261.

Sergeant S, Rahbar E, Chilton FH. Gamma-linolenic acid, dihommo-gamma linolenic, eicosanoids and inflammatory processes. Eur J Pharmacol. 2016;():.

Cui T, Hester AG, Seeds MC, Rahbar E, Howard TD, Sergeant S, Chilton FH. Impact of genetic and epigenetic variations within the FADS cluster on the composition and metabolism of polyunsaturated fatty acids in prostate cancer. Prostate. 2016;():.

Howard TD, Mathias RA, Seeds MC, Herrington DM, Hixson JE, Shimmin LC, Hawkins GA, Sellers M, Ainsworth HC, Sergeant S, Miller LR, Chilton FH. DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver. PLoS One. 2014;9(5):e97510.

Chilton FH, Murphy RC, Wilson BA, Sergeant S, Ainsworth H, Seeds MC, Mathias RA. Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases. Nutrients. 2014;6(5):1993-2022.

Mathias RA, Pani V, Chilton FH. Genetic variants in the FADS gene: implications for dietary recommendations for fatty acid intake. Curr Nutr Rep. 2014;3(2):139-148.

Hester AG, Murphy RC, Uhlson CJ, Ivester P, Lee TC, Sergeant S, Miller LR, Howard TD, Mathias RA, Chilton FH. Relationship between a common variant in the fatty acid desaturase (FADS) cluster and eicosanoid generation in humans. J Biol Chem. 2014;289(32):22482-89.

Kazani S, Arm JP, Boyce J, Chhay H, Dutile S, Wechsler ME, Govindarajulu U, Ivester P, Ainsworth HC, Sergeant S, Chilton FH, Israel E. LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma. Springerplus. 2014;3():661.

Lee TC, Ivester P, Hester AG, Sergeant S, Case LD, Morgan T, Kouba EO, Chilton FH. The impact of polyunsaturated fatty acid-based dietary supplements on disease biomarkers in a metabolic syndrome/diabetes population. Lipids Health Dis. 2014;13(1):196.

Chilton F, Mathias R, Seeds M, Herrington D, Hixson J, Hawkins G, Sergeant S, Miller L, Howard T. DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver [abstract]. FASEB J. 2014;28(1 Suppl):373.8.

Chilton F, Lu F, inventors; Wake Forest University Health Sciences, assignee. Compositions, methods, and kits for polyunsaturated fatty acids from microalgae. United States patent US 8,343,753. 2013 Jan 1. 2013;():.

Kavanagh K, Flynn DM, Jenkins KA, Wilson MD, Chilton FH. Stearidonic and gamma-linolenic acids in echium oil improves glucose disposal in insulin resistant monkeys. Prostaglandins Leukot Essent Fatty Acids. 2013;89(1):39-45.

Arm JP, Boyce JA, Wang L, Chhay H, Zahid M, Patil V, Govindarajulu U, Ivester P, Weaver KL, Sergeant S, Israel E, Chilton FH. Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics. Lipids Health Dis. 2013;12():141.

Sergeant S, Hugenschmidt CE, Rudock ME, Ziegler JT, Ivester P, Ainsworth HC, Vaidya D, Case LD, Langefeld CD, Freedman BI, Bowden DW, Mathias RA, Chilton FH. Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome. Br J Nutr. 2012;107(4):547-555.

Mathias RA, Fu W, Akey JM, Ainsworth HC, Torgerson DG, Ruczinski I, Sergeant S, Barnes KC, Chilton FH. Adaptive evolution of the FADS gene cluster within Africa. PLoS One. 2012;7(9):e44926.

Sergeant S, Lee TC, Ivester P, Ainsworth HC, Case LD, Chilton FH. Botanical oil supplementation alters insulin levels in diabetic/metabolic syndrome subjects in a genotypic-specific manner [abstract]. FASEB J. 2012;26(Meeting Abstracts Suppl):647.11.

Wilson BA, Sergeant S, Ainsworth H, Mathias R, Chilton FH III. Racial differences in plasma omega-3 long chain fatty acid levels in a cohort of African Americans and European Americans with diabetes and metabolic syndrome [abstract]. FASEB J. 2012;26(Meeting Abstracts Suppl):266.4.

Sergeant S, McQuail JA, Riddle DR, Chilton FH, Ortmeier SB, Jessup JA, Groban L, Nicolle MM. Dietary fish oil modestly attenuates the effect of age on diastolic function but has no effect on memory or brain inflammation in aged rats. J Gerontol A Biol Sci Med Sci. 2011;66(5):521-533.

Mathias RA, Sergeant S, Hugenschmidt CE, Ziegler JT, Ivester P, Case D, Freedman BI, Rudock ME, Langefeld CD, Bowden DW, Chilton FH, et al. The impact of FADS genetic variants on omega-6 polyunsaturated fatty acid metabolism in African Americans. BMC Genet. 2011;12():article 50.

Chilton FH, Lee TC, Willard SL, Ivester P, Sergeant S, Register TC, Shively CA. Depression and altered serum lipids in cynomolgus monkeys consuming a Western diet. Physiol Behav. 2011;104(2):222-227.

Mathias RA, Vergara C, Gao L, Rafaels N, Hand T, Campbell M, Bickel C, Ivester P, Sergeant, Chilton FH, et al. FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population. J Lipid Res. 2010;51(9):2766-2774.

Ivester P, Sergeant S, Danhauer SC, Case LD, Lamb A, Chilton BG, Delar B, Hollingshead ML, Weaver KL, Chilton FH. Effect of a multifaceted, church-based wellness program on metabolic syndrome in 41 overweight or obese congregants. Prev Chronic Dis. 2010;7(4):A81.

Weaver KL, Ivester P, Seeds M, Case LD, Arm JP, Chilton FH. Effect of dietary fatty acids on inflammatory gene expression in healthy humans. J Biol Chem. 2009;284(23):15400-7.

Seeds MC, Peachman KK, Bowton DL, Sivertson KL, Chilton FH. Regulation of arachidonate remodeling enzymes impacts eosinophil survival during allergic asthma. Am J Respir Cell Mol Biol. 2009;41(3):358-366.

Houston MC, Fazio S, Chilton FH, Wise DE, Jones KB, Barringer TA, Bramlet DA. Nonpharmacologic treatment of dyslipidemia. Prog Cardiovasc Dis. 2009;52(2):61-94.

Chilton FH, Tucker L. In: The gene smart diet: the revolutionary eating plan that will rewrite your genetic destiny--and melt away the pounds. Emmaus (PA): Rodale;2009: .

Barnes S, Birt DF, Cassileth BR, Cefalu WT, Chilton FH, Farnsworth NR, Raskin I, van Breemen RB, Weaver CM. Technologies and experimental approaches at the National Institutes of Health Botanical Research Centers. Am J Clin Nutr. 2008;87(2 Suppl):476S-480S.

Chilton FH, Rudel LL, Parks JS, Arm JP, Seeds MC. Mechanisms by which botanical lipids affect inflammatory disorders. Am J Clin Nutr. 2008;87(2 Suppl):498S-503S.

Weaver KL, Ivester P, Chilton JA, Wilson MD, Pandey P, Chilton FH. The content of favorable and unfavorable polyunsaturated fatty acids found in commonly eaten fish. J Am Diet Assoc. 2008;108(7):1178-1185.

Chilton FH. Concerning PUFA in fish [reply to letter]. J Am Diet Assoc. 2008;108(11):1831-1832.

Chilton FH. Regarding favorable and unfavorable PUFA in fish [letter]. J Am Diet Assoc. 2008;108(10):1614, 1616.

Weaver KL, Ivester P, Chilton F. Altering in vivo levels of n-6 and n-3 fatty acids in humans modulates the expression of inflammatory genes [abstract]. FASEB J. 2007;21(5):A61.

Monjazeb AM, High KP, Connoy A, Hart LS, Koumenis C, Chilton FH. Arachidonic acid-induced gene expression in colon cancer cells. Carcinogenesis. 2006;27(10):1950-1960.

Chilton F, inventor; Wake Forest University Health Sciences, assignee. Dietary control of arachidonic acid metabolism. United States patent US 7,138,431. 2006 Nov 21. 2006;():.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Floyd H. Chilton, Ph.D.

Floyd H. Chilton, Ph.D.

Professor, Physiology & Pharmacology

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