Profile

George J. Christ, Ph.D.

George J. Christ, Ph.D.

Professor, Institute for Regenerative Medicine
Sticht Center on Aging
WFU Primate Center
Physiology & Pharmacology
Urology
Contact Information
Office:
336-716-2011
Email: gchrist@wakehealth.edu
Education & Training
  BS Muhlenberg College 1982
  PhD Wake Forest University 1987
Fellowship Albert Einstein College of Medicine 1989
George J. Christ, Ph.D.

George J. Christ, Ph.D.

Professor, Institute for Regenerative Medicine
Sticht Center on Aging
WFU Primate Center
Physiology & Pharmacology
Urology
Contact Information
Office:
336-716-2011
Email: gchrist@wakehealth.edu
Research Interests
biotechnology , cell growth, differentiation,d , cross(mult/tnslat/inter)discip , drugs/therapeutic agents pharm , education/training (all f, t, , engineering/bioengineering , model development
Recent Publications
Criswell TL, Corona BT, Ward CL, Miller M, Patel M, Wang Z, Christ GJ, Soker S. Compression-induced muscle injury in rats that mimics compartment syndrome in humans. Am J Pathol. 2012; 180(2):787-797.

Machingal MA, Yazdani SK, Christ GJ. Engineering of large diameter vessels. In: Atala A, Lanza R, Thomson JA, Nerem R, eds. Principles of regenerative medicine. 2nd ed. San Diego (CA): Academic Press; 2011: 833-852.

Christ GJ. Potential applications of gene therapy/transfer to the treatment of lower urinary tract diseases/disorders. Handb Exp Pharmacol. 2011; 202():255-265.

Neff LP, Tillman BW, Yazdani SK, Machingal MA, Yoo JJ, Soker S, Bernish BW, Geary RL, Christ GJ. Vascular smooth muscle enhances functionality of tissue-engineered blood vessels in vivo. J Vasc Surg. 2011; 53(2):426-434.

Kanika ND, Chang J, Tong Y, Tiplitsky S, Lin J, Yohannes E, Tar M, Chance M, Christ GJ, Melman A, et al. Oxidative stress status accompanying diabetic bladder cystopathy results in the activation of protein degradation pathways. BJU Int. 2011; 107(10):1676-1684.

Christ GJ, Chen AF. The grand challenge for integrative and regenerative pharmacology. Front Pharmacol. 2011; 2():article 5.

Machingal MA, Corona BT, Walters TJ, Kesireddy V, Koval CN, Dannahower A, Zhao W, Yoo JJ, Christ GJ. A tissue-engineered muscle repair construct for functional restoration of an irrecoverable muscle injury in a murine model. Tissue Eng Part A. 2011; 17(17-18):2291-2303.

Gratzke C, Christ GJ, Stief CG, Andersson K-E, Hedlund P. Localization and function of cannabinoid receptors in the corpus cavernosum: basis for modulation of nitric oxide synthase nerve activity. Eur Urol. 2010; 57(2):342-349.

Christ GJ, Melman A, Williams K, Aboushwareb T, Zhao WX, Kaplan J, Anderson K-E [sic] [Andersson K-E]. Nonhuman primates as a model for translational research on atherosclerosis-related vascular disease and erectile dysfunction [abstract]. J Sex Med. 2010; 7(Suppl 1):46.

Fullhase C, Soler R, Gratzke C, Brodsky M, Christ GJ, Andersson K-E. Urodynamic evaluation of fesoterodine metabolite, doxazosin and their combination in a rat model of partial urethral obstruction. BJU Int. 2010; 106(2):287-293.

Zhao W, Aboushwareb T, Turner C, Mathis C, Bennett C, Sonntag WE, Andersson K-E, Christ G. Impaired bladder function in aging male rats. J Urol. 2010; 184(1):378-385.

Fullhase C, Soler R, Gratzke C, Brodsky M, Christ GJ, Andersson K-E. Spinal effects of the fesoterodine metabolite 5-hydroxymethyl tolterodine and/or doxazosin in rats with or without partial urethral obstruction. J Urol. 2010; 184(2):783-789.

Burmeister D, AbouShwareb T, Tan J, Link K, Andersson K-E, Christ G. Early stages of in situ bladder regeneration in a rodent model. Tissue Eng Part A. 2010; 16(8):2541-2551.

Corona BT, Ward CL, Harrison BS, Christ GJ. Regenerative medicine: basic concepts, current status, and future applications. J Investig Med. 2010; 58(7):849-858.

Neff LP, Tillman B, Yazadani S, Machinga M, Yoo J, Soker S, Bernishi B, Geary R, Christ G. Vascular smooth muscle enhances functionality of tissue engineered blood vessels in vivo [abstract]. J Vasc Surg. 2010; 51(Suppl):4S.

Burnett AL, Goldstein I, Andersson KE, Argiolas A, Christ G, Park K, Xin ZC. Future sexual medicine physiological treatment targets. J Sex Med. 2010; 7(10):3269-3304.

Gratzke C, Streng T, Park A, Christ G, Stief CG, Hedlund P, Andersson K-E. Distribution and function of cannabinoid receptors 1 and 2 in the rat, monkey and human bladder. J Urol. 2009; 181(4):1939-1948.

Goldstein AS, Christ G. Functional tissue engineering requires bioreactor strategies [preface]. Tissue Eng Part A. 2009; 15(4):739-740.

Yazdani SK, Watts B, Machingal M, Jarajapu YPR, Van Dyke ME, Christ GJ. Smooth muscle cell seeding of decellularized scaffolds: the importance of bioreactor preconditioning to development of a more native architecture for tissue-engineered blood vessels. Tissue Eng Part A. 2009; 15(4):827-840.

Christ GJ. Bladder tissue regeneration [editorial]. J Urol. 2009; 182(1):16-17.

Zhao W, Sato Y, Melman A, Andersson KE, Christ G. Metrics for evaluation of age-related changes in erectile capacity in a rodent model. J Sex Med. 2009; 6(7):1885-1892.

Markert CD, Atala A, Cann JK, Christ G, Furth M, Ambrosio F, Childers MK. Mesenchymal stem cells: emerging therapy for Duchenne muscular dystrophy. PM R. 2009; 1(6):547-559.

Aboushwareb T, Zhou G, Deng F-M, Turner C, Andersson K-E, Tar M, Zhao W, D'Agostino R Jr, Sun T-T, Christ GJ, et al. Alterations in bladder function associated with urothelial defects in uroplakin II and IIIa knockout mice. Neurourol Urodyn. 2009; 28(8):1028-1033.

Furth ME, Christ GJ. Regenerative pharmacology for diabetes mellitus. Mol Interv. 2009; 9(4):171-174.

Burmeister D, AbouShwareb T, Andersson K, Christ G. Establishing a rodent model for characterization of natural in vivo bladder regeneration [abstract]. Neurourol Urodyn. 2009; 28(7):739-741.

Schlatzer DM, Dazard JE, Dharsee M, Ewing RM, Ilchenko S, Stewart I, Christ G, Chance MR. Urinary protein profiles in a rat model for diabetic complications. Mol Cell Proteomics. 2009; 8(9):2145-2158.

Zhao W, Brink P, Christ G. Altered camp-mediated potassium channel currents in detrusor myocytes from diabetic rats [abstract]. Neurourol Urodyn. 2009; 28(7):744-745.

Christ GJ, Andersson K-E, Williams K, Zhao W, D'Agostino R Jr, Kaplan J, Aboushwareb T, Yoo J, Calenda G, Davies KP, et al. Smooth-muscle-specific gene transfer with the human Maxi-K channel improves erectile function and enhances sexual behavior in atherosclerotic cynomolgus monkeys. Eur Urol. 2009; 56(6):1055-1066.

Melman A, Rojas L, Christ G. Gene transfer for erectile dysfunction: will this novel therapy be accepted by urologists?. Curr Opin Urol. 2009; 19(6):595-600.

Christ GJ, Bushman W, Fraser MO. Impact of diabetes and obesity on the prostate and urethra: implications to improved bladder dysfunction understanding and treatment. J Urol. 2009; 182(6):S38-S44.

Yazdani SK, Christ GJ. Engineering of large diameter vessels. In: Atala A, Lanza R, Thomson JA, Nerem RM, eds. Principles of regenerative medicine. Boston (MA): Academic Press; 2008: 978-999.

Aboushwareb T, Burmeister D, Andersson KE, Christ GJ. Novel longitudinal studies of rat bladder regeneration [abstract]. Eur Urol Suppl. 2008; 7(3):266.

Christ GJ, Andersson K-E, Williams K, Zhao W, D'Agostino R, Kaplan J, Aboushwareb T, Yoo J, Davies K, Melman A. MAXI-K gene transfer with a smooth muscle specific promoter enhances erectile function and sexual behaviour in atherosclerotic cynomolgous monkeys [abstract]. Eur Urol. 2008; 7(3 Suppl):143.

Gratzke C, Christ GJ, Kaplan JR, Stief CG, Andersson KE, Badlani G. Chronic soy and phytoestrogen treatment leads to significant functional and morphological changes in the urethra of oophorectomized female non-human primates [abstract]. Eur Urol. 2008; 7(3 Suppl):315.

Gratzke C, Christ GJ, Kaplan JR, Andersson K-E, Badlani G. Chronic soy and phytoestrogen treatment leads to significant functional and morphological changes in the urethra of female non-human primates [abstract]. Neurourol Urodyn. 2008; 27(2):106.

Hodges SJ, Zhou G, Deng F-M, Aboushwareb T, Turner C, Andersson K-E, Santago P, Case D, Sun T-T, Christ GJ. Voiding pattern analysis as a surrogate for cystometric evaluation in uroplakin II knockout mice. J Urol. 2008; 179(5):2046-2051.

Melman A, Biggs G, Davies K, Zhao W, Tar MT, Christ GJ. Gene transfer with a vector expressing Maxi-K from a smooth muscle-specific promoter restores erectile function in the aging rat. Gene Ther. 2008; 15(5):364-370.

Zhao W, Machigal M, Turner C, Davies K, Melman A, Andersson KE, Christ GJ. Threshold gene transfer with hSlo enhances sildenafil-induced erectile responses in 2-month streptozotocin (STZ)-diabetic rats [abstract]. Eur Urol. 2008; 7(3 Suppl):217.

Moon DG, Christ G, Stitzel JD, Atala A, Yoo JJ. Cyclic mechanical preconditioning improves engineered muscle contraction. Tissue Eng Part A. 2008; 14(4):473-482.

Choi JS, Lee SJ, Christ GJ, Atala A, Yoo JJ. The influence of electrospun aligned poly(epsilon-caprolactone)/collagen nanofiber meshes on the formation of self-aligned skeletal muscle myotubes. Biomaterials. 2008; 29(19):2899-2906.

Christ GJ. Engineering muscularized vascular conduits [abstract]. Tissue Eng Part A. 2008; 14(5):848.

Yazdani SK, Watts B, Machingal M, Jarajapu YPR, Van Dyke ME, Christ GJ. Smooth muscle cell seeding of decellularized scaffolds: further development toward a more native architecture for tissue engineered blood vessels [abstract]. Tissue Eng Part A. 2008; 14(5):778.

Yohannes E, Chang J, Christ GJ, Davies KP, Chance MR. Proteomics analysis identifies molecular targets related to diabetes mellitus-associated bladder dysfunction. Mol Cell Proteomics. 2008; 7(7):1270-1285.

Gratzke C, Jarajapu YPR, Christ GJ, Kaplan JR, Williams JK, Andersson K-E, Badlani G. Effects of long-term dietary soy treatment on female urethral morphology and function in ovariectomized nonhuman primates. J Urol. 2008; 180(5):2247-2253.

Hipp JD, Davies KP, Tar M, Valcic M, Knoll A, Melman A, Christ GJ. Using gene chips to identify organ-specific, smooth muscle responses to experimental diabetes: potential applications to urological diseases. BJU Int. 2007; 99(2):418-430.

Christ G, Andersson KE, Atala A. The future of bladder research: molecular profiling, new drug targets, gene therapy, and tissue engineering. Curr Urol Rep. 2007; 8(2):95-99.

Melman A, Bar-Chama N, McCullough A, Davies K, Christ G. Plasmid-based gene transfer for treatment of erectile dysfunction and overactive bladder: results of a phase I trial. Isr Med Assoc J. 2007; 9(3):143-146.

Aboushwareb T, Jarajapu YPR, Blaha S, Hodges S, Turner C, Zhao W, Andersson K-E, Christ GJ. Mechanistic studies of detrusor over activity in male rats following partial urethral obstruction: implications to identification of novel therapeutics [abstract]. FASEB J. 2007; 21(6):A1356.

Aboushwareb T, Zho G, Turner C, Andersson K-E, Tar M, Melman A, Deng F-M, Sun T-T, Christ GJ. Urodynamic characterization of mice lacking uroplakin II or III [abstract]. FASEB J. 2007; 21(6):A1308.

Aboushwareb T, Andersson K-E, Christ GJ. Pharmacological studies of AGI-1140 in a rat model of erectile dysfunction [abstract]. FASEB J. 2007; 21(6):A1159-1160.

Andersson KE, Christ GJ. Regenerative pharmacology: the future is now. Mol Interv. 2007; 7(2):79-86.

Hodges S, Zhou G, Deng F-M, Abouschwareb T, Turner C, Andersson K-E, Santago P, Sun H, Christ GJ. Voiding patterns in uroplakin II knockout mice [abstract]. FASEB J. 2007; 21(6):A1301.

Jarajapu YPR, Christ GJ, Knot HJ. Intravascular pressure causes novel synchronous intercellular Ca2+ oscillations in rat cerebral arteries [abstract]. FASEB J. 2007; 21(6):A1157.

Yazdani SK, Machingal M, Watts B, Jarajapu YPR, Van Dyke ME, Christ GJ. Smooth muscle seeded natural collagen scaffolds for tissue engineered blood vessels [abstract]. FASEB J. 2007; 21(5):A81.

Zhao W, Machingal M, Turner C, Davies K, Andersson K-E, Melman A, Christ GJ. Threshold gene transfer with hSlo enhances sildenafil-induced erectile responses in 2 month streptozotocin(STZ)-diabetic rats [abstract]. FASEB J. 2007; 21(5):A420.

Delo D, Neshat S, Christ G, Groban L, Olson J, Zhu J-M, Atala A, Soker S. Amniotic fluid derived stem cells for cardiac therapeutics [abstract]. FASEB J. 2007; 21(5):A229.

Zare S, Christ G, Moon DG, Zhao W, Atala A, Yoo JJ. Functional enhancement of bioreactor assisted engineered skeletal muscle [abstract]. FASEB J. 2007; 21(5):A135.

Zhao W, Brink PR, Christ GJ. Diabetes-related alterations in cAMP-mediated potassium channel currents in short term cultures of detrusor myocytes [abstract]. FASEB J. 2007; 21(6):A829.

Zotova EG, Christ GJ, Zhao W, Tar M, Kuppam SD, Arezzo JC. Effects of fidarestat, an aldose reductase inhibitor, on nerve conduction velocity and bladder function in streptozotocin-treated female rats. J Diabetes Complications. 2007; 21(3):187-195.

Moon DG, Christ GJ, Stitzel J, Yoo JJ, Atala A. Tissue bioreactor system for the creation and maturation of organized functional tissues for surgical reconstruction [abstract]. J Urol. 2007; 177(4 Suppl):58-59.

Aboushwareb TA, Zhou G, Turner C, Andersson KE, Tar M, Melman A, Deng FM, Sun TT, Christ GJ. Urodynamic studies in uroplakin II or III knockout (KO) mice [abstract]. J Urol. 2007; 177(4 Suppl):88.

Rodriguez S, Chen KL, Christ GJ, Yoo JJ, Atala A. Progenitor cell-derived endothelial cell therapy restores diabetes associated erectile dysfunction [abstract]. J Urol. 2007; 177(4 Suppl):264.

Christ GJ, Andersson KE. Rho-kinase and effects of Rho-kinase inhibition on the lower urinary tract. Neurourol Urodyn. 2007; 26(Suppl 6):948-954.

Yazdani SK, Jarajapu YPR, Machinga M [sic] [Machingal M], Watts B, Van Dyke ME, Christ GJ. Bioreactor protocols for improved cellular penetration of decellularized scaffolds [abstract]. Tissue Eng. 2007; 13(7):1645.

Yazdani SK, Jarajapu YPR, Machingal M, Watts B, Van Dyke ME, Christ GJ. Development of tissue engineered blood vessels with a functional medial muscle layer [abstract]. Tissue Eng. 2007; 13(7):1673.

Zare S, Christ G, Moon DG, Zhao W, Atala A, Yoo JJ. Functional enhancement of bioreactor assisted engineered skeletal muscle [abstract]. Tissue Eng. 2007; 13(7):1698.

Moon DG, Tillman B, Christ G, Stitzel J, Yoo J, Atala A. Tissue bioreactor system for the creation and maturation of organized functional tissues for surgical reconstruction [abstract]. J Am Coll Surg. 2007; 205(3 Suppl):S104.

Davies KP, Zhao W, Tar M, Figueroa JC, Desai P, Verselis VK, Kronengold J, Wang H-Z, Melman A, Christ GJ. Diabetes-induced changes in the alternative splicing of the Slo gene in corporal tissue. Eur Urol. 2007; 52(4):1229-1237.

Tong Y, Tar M, Davelman F, Christ G, Melman A, Davies KP. Variable coding sequence protein A1 as a marker for erectile dysfunction. BJU Int. 2006; 98(2):396-401.

Wang H-Z, Brink PR, Christ GJ. Gap junction channel activity in short-term cultured human detrusor myocyte cell pairs: gating and unitary conductances. Am J Physiol Cell Physiol. 2006; 291(6):C1366-1376.

Delo D, Neshat-Vahid S, Olson J, Zhu JM, Christ G, Atala A. Amniotic fluid derived stem cells for cardiac therapeutics [abstract]. Circulation. 2006; 114(18 Suppl):197-198.

Neshat-Vahid S, Delo D, Milanesi A, Christ G, Atala A, Soker S. Amniotic fluid derived stem cells for cardiac therapeutics [abstract]. Eur Heart J. 2006; 27(Suppl 1):19-20.

Brink PR, Valiunas V, Wang H-Z, Zhao W, Davies K, Christ GJ. Experimental diabetes alters connexin43 derived gap junction permeability in short-term cultures of rat corporeal vascular smooth muscle cells. J Urol. 2006; 175(1):381-386.

Melman A, Bar-Chama N, McCullough AR, Davies K, Christ GJ. Results of the first human trial for genetransfer therapy for the treatment of erectile dysfunction [abstract]. J Urol. 2006; 175(4 Suppl):222.

Lowe D, Tar M, Du Hoffmann J, Christ GJ, Davies K, Melman A. Efficacy of weekly administration of hSlo (hMaxi-K) gene transfer for treatment of erectile dysfunction in aging rats [abstract]. J Urol. 2006; 175(4 Suppl):223.

Melman A, Bar-chama N, McCullough A, Davies K, Christ G. hMaxi-K gene transfer in males with erectile dysfunction: results of the first human trial. Hum Gene Ther. 2006; 17(12):1165-1176.
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Last Updated 3/30/2012
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