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Henry A. Claiborne, Ph.D.Wake Forest School of Medicine

Henry A. Claiborne, Ph.D.


Contact Information

Academic: 336-716-3914 | Department: 336-716-3914


Education & Training

  • B.A., Vanderbilt University, 1974
  • Ph.D., Duke University, 1979
  • Fellowship, Univ of Michigan Ann Arbor, 1983


  • Am Assn Of Advancement Of Scie
  • Am Chemical Society
  • Am Soc Of Biochem & Mol Biolog
  • Am Soc of Microbiology
Henry A. Claiborne, Ph.D.

Henry A. Claiborne, Ph.D.

Professor, Biochemistry

Contact Information

Academic: 336-716-3914 | Department: 336-716-3914


Recent Publications

Structural analysis of Streptococcus pyogenes NADH oxidase: conformational dynamics involved in formation of the C(4a)-peroxyflavin intermediate. Wallen JR, Mallett TC, Okuno T, Parsonage D, Sakai H, Tsukihara T, Claiborne A.. Biochemistry. 2015;54(45):6815-6829.

Cross-functionalities of Bacillus deacetylases involved in bacillithiol biosynthesis and bacillithiol-S-conjugate detoxification pathways. Fang Z, Roberts AA, Weidman K, Sharma SV, Claiborne A, Hamilton CJ, Dos Santos PC.. Biochem J. 2013;454(Pt 2):239-247.

Turnover-dependent covalent inactivation of Staphylococcus aureus coenzyme A-disulfide reductase by coenzyme A-mimetics: mechanistic and structural insights. Wallace BD, Edwards JS, Wallen JR, Moolman WJ, van der Westhuyzen R, Strauss E, Redinbo MR, Claiborne A.. Biochemistry. 2012;51(39):7699-7711.

The coenzyme A disulphide reductase of Borrelia burgdorferi is important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian host. Eggers CH, Caimano MJ, Malizia RA, Kariu T, Cusack B, Desrosiers DC, Hazlett KRO, Claiborne A, Pal U, Radolf JD.. Mol Microbiol. 2011;82(3):679-697.

Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli. Gaballa A, Newton GL, Antelmann H, Parsonage D, Upton H, Rawat M, Claiborne A, Fahey RC, Helmann JD.. Proc Natl Acad Sci U S A. 2010;107(14):6482-6486.

Characterization of the N-acetyl-alpha-D-glucosaminyl l-malate synthase and deacetylase functions for bacillithiol biosynthesis in Bacillus anthracis. Parsonage D, Newton GL, Holder RC, Wallace BD, Paige C, Hamilton CJ, Dos Santos PC, Redinbo MR, Reid SD, Claiborne A.. Biochemistry. 2010;49(38):8398-8414.

Crystal structure and catalytic properties of Bacillus anthracis CoADR-RHD: implications for flavin-linked sulfur trafficking. Wallen JR, Mallett TC, Boles W, Parsonage D, Furdui CM, Karplus PA, Claiborne A.. Biochemistry. 2009;48(40):9650-9667.

Bacillithiol is an antioxidant thiol produced in Bacilli. Newton GL, Rawat M, La Clair JJ, Jothivasan VK, Budiarto T, Hamilton CJ, Claiborne A, Helmann JD, Fahey RC.. Nat Chem Biol. 2009;5(9):625-627.

Nucleoside triphosphate mimicry: a sugar triazolyl nucleoside as an ATP-competitive inhibitor of B. anthracis pantothenate kinase. Rowan AS, Nicely NI, Cochrane N, Wlassoff WA, Claiborne A, Hamilton CJ.. Org Biomol Chem. 2009;7(19):4029-4036.

Structure of alpha-glycerophosphate oxidase from Streptococcus sp.: a template for the mitochondrial alpha-glycerophosphate dehydrogenase. Colussi T, Parsonage D, Boles W, Matsouka T, Mallett TC, Karplus PA, Claiborne A.. Biochemistry. 2008;47(3):965-977.

Pyridine nucleotide complexes with Bacillus anthracis coenzyme A-disulfide reductase: a structural analysis of dual NAD(P)H specificity. Wallen JR, Paige C, Mallett TC, Karplus PA, Claiborne A.. Biochemistry. 2008;47(18):5182-5193.

The type III pantothenate kinase encoded by coaX is essential for growth of Bacillus anthracis. Paige C, Reid SD, Hanna PC, Claiborne A.. J Bacteriol. 2008;190(18):6271-6275.

Structure of the type III pantothenate kinase from Bacillus anthracis at 2.0 angstrom resolution: implications for coenzyme A-dependent redox biology. Nicely NI, Parsonage D, Paige C, Newton GL, Fahey RC, Leonardi R, Jackowski S, Mallett TC, Claiborne A.. Biochemistry. 2007;46(11):3234-3245.

Structure of coenzyme A--disulfide reductase from Staphylococcus aureus at 1.54 angstrom resolution. Mallett TC, Wallen JR, Karplus PA, Sakai H, Tsukihara T, Claiborne A.. Biochemistry. 2006;45(38):11278-89.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Biochemistry

Henry A. Claiborne, Ph.D.

Henry A. Claiborne, Ph.D.

Professor, Biochemistry

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