Henry A. Claiborne, Ph.D., Professor Biochemistry - Wake Forest School of Medicine

Henry A. Claiborne, Ph.D.

Professor, Biochemistry

Contact Information

Academic: 336-716-3914 | Department: 336-716-3914

Email: aclaibor@wakehealth.edu

Education & Training

B.A., Vanderbilt University , 1974
Ph.D., Duke University , 1979
Fellowship, University of Michigan/Ann Arbor, 1983

Memberships

Am Assn Of Advancement Of Scie
Am Chemical Society
Am Soc Of Biochem & Mol Biolog
Am Soc Of Microbiology

Henry A. Claiborne, Ph.D.

Professor, Biochemistry

Research Interests

computer science, drugs/therapeutic agents pharm, infectious diseases, medical technology/devices, molecular biology/molecular me, structural biology, surgery/trauma/burns/trauma

Contact Information

Academic: 336-716-3914 | Department: 336-716-3914

Email: aclaibor@wakehealth.edu

Recent Publications

Wallace BD, Edwards JS, Wallen JR, Moolman WJ, van der Westhuyzen R, Strauss E, Redinbo MR, Claiborne A. Turnover-dependent covalent inactivation of Staphylococcus aureus coenzyme A-disulfide reductase by coenzyme A-mimetics: mechanistic and structural insights. Biochemistry. 2012;51(39):7699-7711.

Eggers CH, Caimano MJ, Malizia RA, Kariu T, Cusack B, Desrosiers DC, Hazlett KRO, Claiborne A, Pal U, Radolf JD. The coenzyme A disulphide reductase of Borrelia burgdorferi is important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian host. Mol Microbiol. 2011;82(3):679-697.

Gaballa A, Newton GL, Antelmann H, Parsonage D, Upton H, Rawat M, Claiborne A, Fahey RC, Helmann JD. Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli. Proc Natl Acad Sci U S A. 2010;107(14):6482-6486.

Parsonage D, Newton GL, Holder RC, Wallace BD, Paige C, Hamilton CJ, Dos Santos PC, Redinbo MR, Reid SD, Claiborne A. Characterization of the N-acetyl-alpha-D-glucosaminyl l-malate synthase and deacetylase functions for bacillithiol biosynthesis in Bacillus anthracis. Biochemistry. 2010;49(38):8398-8414.

Wallen JR, Mallett TC, Boles W, Parsonage D, Furdui CM, Karplus PA, Claiborne A. Crystal structure and catalytic properties of Bacillus anthracis CoADR-RHD: implications for flavin-linked sulfur trafficking. Biochemistry. 2009;48(40):9650-9667.

Newton GL, Rawat M, La Clair JJ, Jothivasan VK, Budiarto T, Hamilton CJ, Claiborne A, Helmann JD, Fahey RC. Bacillithiol is an antioxidant thiol produced in Bacilli. Nat Chem Biol. 2009;5(9):625-627.

Rowan AS, Nicely NI, Cochrane N, Wlassoff WA, Claiborne A, Hamilton CJ. Nucleoside triphosphate mimicry: a sugar triazolyl nucleoside as an ATP-competitive inhibitor of B. anthracis pantothenate kinase. Org Biomol Chem. 2009;7(19):4029-4036.

Colussi T, Parsonage D, Boles W, Matsouka T, Mallett TC, Karplus PA, Claiborne A. Structure of alpha-glycerophosphate oxidase from Streptococcus sp.: a template for the mitochondrial alpha-glycerophosphate dehydrogenase. Biochemistry. 2008;47(3):965-977.

Wallen JR, Paige C, Mallett TC, Karplus PA, Claiborne A. Pyridine nucleotide complexes with Bacillus anthracis coenzyme A-disulfide reductase: a structural analysis of dual NAD(P)H specificity. Biochemistry. 2008;47(18):5182-5193.

Paige C, Reid SD, Hanna PC, Claiborne A. The type III pantothenate kinase encoded by coaX is essential for growth of Bacillus anthracis. J Bacteriol. 2008;190(18):6271-6275.

Nicely NI, Parsonage D, Paige C, Newton GL, Fahey RC, Leonardi R, Jackowski S, Mallett TC, Claiborne A. Structure of the type III pantothenate kinase from Bacillus anthracis at 2.0 angstrom resolution: implications for coenzyme A-dependent redox biology. Biochemistry. 2007;46(11):3234-3245.

Mallett TC, Wallen JR, Karplus PA, Sakai H, Tsukihara T, Claiborne A. Structure of coenzyme A--disulfide reductase from Staphylococcus aureus at 1.54 angstrom resolution. Biochemistry. 2006;45(38):11278-89.