Profile

Thomas B. Clarkson, D.V.M.Wake Forest School of Medicine

Thomas B. Clarkson, D.V.M.

Professor,

Clinical Specialties

Hormone Replacement Therapy and Menopause, Atherosclerosis

Contact Information

Academic: 336-716-1570 | Department: 336-716-1570

Email: tclarkso@wakehealth.edu

Related Links

Education & Training

  • D.V.M., University of Georgia , 1954

Board Certifications

  • American Veterinary Medical Association, American College of Laboratory Animal Medicine

Memberships

  • Am Assn Of Advncmnt Of Lab Anm
  • North Am Menopause Soc
  • NC Assn for Biomed Research
  • Soc Of Behavioral Medicine
  • So.For Experimental Biology &
  • Acad for Beh Medicine Research
  • Am Heart Association
  • Am Soc for Inv Pathology
  • Am Soc Of Experimental Path.
  • Am Soc Of Primatologists
  • Am Veterinary Medical Assn
Thomas B. Clarkson, D.V.M.

Thomas B. Clarkson, D.V.M.

Professor, Pathology-Comparative Medicine
Center for Comparative Medicine Research

Contact Information

Academic: 336-716-1570 | Department: 336-716-1570

Email: tclarkso@wakehealth.edu

Related Links

Recent Publications

Eyster KM, Appt S, Chalpe A, Mark-Kappeler CJ, Register TC, Clarkson TB. Effects of estradiol on transcriptional profiles in atherosclerotic iliac arteries in ovariectomized cynomolgus macaques. Menopause. 2014;21(2):143-152.

Eyster K, Appt S, Chalpe A, Register T, Clarkson T. Effects of equol on gene expression in female cynomolgus monkey iliac arteries. Nutr Metab Cardiovasc Dis. 2014;24(4):423-427.


Melendez GC, Register TC, Appt SE, Clarkson TB, Franke AA, Kaplan JR. Beneficial effects of soy supplementation on postmenopausal atherosclerosis are dependent on pretreatment stage of plaque progression. Menopause. 2014;():.


Clarkson TB, Melendez GC, Appt SE. Timing hypothesis for postmenopausal hormone therapy: its origin, current status, and future. Menopause. 2013;20(3):342-353.

Sophonsritsuk A, Appt SE, Clarkson TB, Shively CA, Espeland MA, Register TC. Differential effects of estradiol on carotid artery inflammation when administered early versus late after surgical menopause. Menopause. 2013;20(5):540-547.

Ethun KF, Wood CE, Cline JM, Register TC, Appt SE, Clarkson TB. Endometrial profile of bazedoxifene acetate alone and in combination with conjugated equine estrogens in a primate model. Menopause. 2013;20(7):777-784.

Appt SE, Kaplan JR, Clarkson TB. Premenopausal antimullerian hormone is a risk marker for postmenopausal coronary artery atherosclerosis progression in cynomolgus monkeys [abstract]. Menopause. 2013;20(12):1324.

Shelton KA, Clarkson TB, Kaplan JR.Nonhuman primate models of atherosclerosis

Schnatz PF, Nudy M, O'Sullivan DM, Jiang X, Cline JM, Kaplan JR, Clarkson TB, Appt SE. Coronary artery vitamin D receptor expression and plasma concentrations of 25-hydroxyvitamin D: their association with atherosclerosis. Menopause. 2012;19(9):967-973.

Schnatz PF, Marakovits KA, O'Sullivan DM, Ethun K, Clarkson TB, Appt SE. Response to an adequate dietary intake of vitamin D3 modulates the effect of estrogen therapy on bone density. J Womens Health. 2012;21(8):858-864.

Jorgensen MJ, Rudel LL, Nudy M, Kaplan JR, Clarkson TB, Pajewski NM, Schnatz PF. 25(OH)D3 and cardiovascular risk factors in female nonhuman primates. J Womens Health. 2012;21(9):959-965.

Schnatz PF, Vila-Wright S, Jiang X, Register TC, Kaplan JR, Clarkson TB, Appt SE. The association between plasma 25-hydroxyvitamin D3 concentrations, C-reactive protein levels, and coronary artery atherosclerosis in postmenopausal monkeys. Menopause. 2012;19(10):1074-1080.

Schnatz PF, Nudy M, O'Sullivan DM, Jiang X, Cline JM, Kaplan JR, Clarkson TB, Appt SE. The quantification of vitamin D receptors in coronary arteries and their association with atherosclerosis. Maturitas. 2012;73(2):143-147.

Appt SE, Chen H, Clarkson TB, Kaplan JR. Premenopausal antimullerian hormone concentration is associated with subsequent atherosclerosis. Menopause. 2012;19(12):1353-1359.

Ethun KF, Wood CE, Register TC, Cline JM, Appt SE, Clarkson TB. Effects of bazedoxifene acetate with and without conjugated equine estrogens on the breast of postmenopausal monkeys. Menopause. 2012;19(11):1242-1252.


Schnatz PF, Nudy M, O'Sullivan DM, Ethun K, Appt SE, Clarkson TB. Identification of a mechanism for increased cardiovascular risk among individuals with low vitamin D concentrations. Menopause. 2011;18(9):994-1000.


Eyster KM, Appt SE, Mark-Kappeler CJ, Chalpe A, Register TC, Clarkson TB. Gene expression signatures differ with extent of atherosclerosis in monkey iliac artery. Menopause. 2011;18(10):1087-1095.

Appt SE, Kavanagh K, Chen H, Kaplan JR, Lazar J, Clarkson TB. Pulse wave velocity is positively correlated with atherosclerosis extent in midlife female nonhuman primates [abstract]. Menopause. 2011;18(12):1348.

Jorgensen MJ, Schnatz PF, Rudel LL, Nudy M, Kaplan JR, Clarkson TB. Low plasma concentrations of vitamin D3 are associated with increased cardiovascular risk factors in a female nonhuman primate model [abstract]. Menopause. 2011;18(12):1345.

Schnatz PF, Vila-Wright S, Jiang X, Register TC, Appt SE, Kaplan JR, Clarkson TB. An inverse relationship between plasma vitamin D concentrations and C-reactive protein provides a potential mechanism for cardioprotection [abstract]. Menopause. 2011;18(12):1352.

Appt SE, Chen H, Goode AK, Hoyer PB, Clarkson TB, Adams MR, Wilson ME, Franke AA, Kaplan JR. The effect of diet and cardiovascular risk on ovarian aging in cynomolgus monkeys (Macaca fascicularis). Menopause. 2010;17(4):741-748.

Sophonsritsuk A, Appt SE, Clarkson TB, Register TC. Estrogen therapy and cardiovascular disease: could arterial expression of interleukin 17 provide some answers to the timing hypothesis? A study of early and late menopause in non-human primates [abstract]. Fertil Steril. 2010;94(4 Suppl 1):S43-S44.

Appt SE, Clarkson TB, Hoyer PB, Kock ND, Goode AK, May MC, Persyn JT, Ethun KF, Chen H, Kaplan JR, et al. Experimental induction of reduced ovarian reserve in a nonhuman primate model (Macaca fascicularis). Comp Med. 2010;60(5):380-388.

Kaplan JR, Chen H, Appt SE, Lees CJ, Franke AA, Berga SL, Wilson ME, Manuck SB, Clarkson TB. Impairment of ovarian function and associated health-related abnormalities are attributable to low social status in premenopausal monkeys and not mitigated by a high-isoflavone soy diet. Hum Reprod. 2010;25(12):3083-3094.

Nielsen M, Ganz M, Lauze F, Pettersen PC, de Bruijne M, Clarkson TB, Dam EB, Christiansen C, Karsdal MA. Distribution, size, shape, growth potential and extent of abdominal aortic calcified deposits predict mortality in postmenopausal women. BMC Cardiovasc Disord. 2010;10():article 56.

Schnatz PF, O'Sullivan DM, Ethun KF, Appt SE, Clarkson TB. Individual differences in plasma concentrations of vitamin D3 are associated with the beneficial effect of estrogen treatment on bone density of surgically postmenopausal monkeys [abstract]. Menopause. 2010;17(6):1225.

Schnatz PF, Shively CA, Millan L, Powell A, O'Sullivan DM, Clarkson TB. The association of cardiovascular disease and depression in menopausal age women: translational findings [abstract]. Menopause. 2010;17(6):1240.

Ethun KF, Wood CE, Appt SE, Cline JM, Chen H, Clarkson TB. Effects of combination therapy with bazedoxifene and conjugated equine estrogens on the endometrial and vaginal epithelium of surgically postmenopausal monkeys [abstract]. Endocr Rev. 2010;31(3 Suppl 1):S1303.

Appt SE, Clarkson TB, Chen H, Adams MR, Christian PJ, Hoyer PB, Wilson ME, Kaplan JR. Serum antimullerian hormone predicts ovarian reserve in a monkey model. Menopause. 2009;16(3):597-601.

Shively CA, Register TC, Clarkson TB. Social stress, visceral obesity, and coronary artery atherosclerosis: product of a primate adaptation. Am J Primatol. 2009;71(9):742-751.

Appt SE, Clarkson TB, Chen H, Adams MR, Christian PJ, Hoyer PB, Wilson ME, Kaplan JR. Serum antimullerian hormone predicts ovarian reserve in a monkey model [abstract]. J Womens Health. 2009;18(5):744.


Clarkson TB, Mehaffey MH. Coronary heart disease of females: lessons learned from nonhuman primates. Am J Primatol. 2009;71(9):785-793.



Tormala R, Appt S, Clarkson TB, Groop P-H, Ronnback M, Ylikorkala O, Mikkola TS. Equol production capability is associated with favorable vascular function in postmenopausal women using tibolone; no effect with soy supplementation. Atherosclerosis. 2008;198(1):174-178.

Shively CA, Register TC, Adams MR, Golden DL, Willard SL, Clarkson TB. Depressive behavior and coronary artery atherogenesis in adult female cynomolgus monkeys. Psychosom Med. 2008;70(6):637-645.

Appt SE, Tormala R, Franke AA, Mikkola TS, Tikkanen MJ, Ylikorkala O, Clarkson TB. Soy-tibolone combination--effect on lipids in postmenopausal monkeys and women. Maturitas. 2008;60(3-4):216-222.

Tormala R, Appt S, Clarkson TB, Mueck AO, Seeger H, Mikkola TS, Ylikorkala O. Impact of soy supplementation on sex steroids and vascular inflammation markers in postmenopausal women using tibolone: role of equol production capability. Climacteric. 2008;11(5):409-415.

Walker SE, Register TC, Appt SE, Adams MR, Clarkson TB, Chen H, Isom S, Franke AA, Kaplan JR. Plasma lipid-dependent and -independent effects of dietary soy protein and social status on atherogenesis in premenopausal monkeys: implications for postmenopausal atherosclerosis burden. Menopause. 2008;15(5):950-957.

Wood CE, Clarkson TB, Chen H, Veenstra TD, Xu X, Scott L, Cline JM. Comparative effects of oral conjugated equine estrogens and micronized 17 beta-estradiol on breast proliferation: a retrospective analysis. Menopause. 2008;15(5):890-898.

Appt SE, Clarkson TB, Adams MR, Hoyer PB, Christian PJ, Kaplan JR. Dietary soy with isoflavones retards ovarian aging [abstract]. Menopause. 2008;15(6):1210.

Shively CA, Register TC, Adams MR, Golden DL, Willard SL, Clarkson TB. Depressive behavior and coronary artery atherogenesis in adult female cynomolgus monkeys [abstract]. Menopause. 2008;15(6):1211.

Utian WH, Archer DF, Bachmann GA, Gallagher C, Grodstein F, Heiman JR, Henderson VW, Hodis HN, Karas RH, Clarkson TB, et al. Estrogen and progestogen use in postmenopausal women: July 2008 position statement of The North American Menopause Society. Menopause. 2008;15(4 Pt 1):584-602.


Shively CA, Clarkson TB. Contributions of a macaque model of women's health [abstract]. Am J Primatol. 2007;69(Suppl 1):69-70.

Clarkson TB. Stage of reproductive life, atherosclerosis progression and estrogen effects on coronary artery atherosclerosis [abstract]. Am J Primatol. 2007;69(Suppl 1):71-72.

Register TC, Walker SE, Shively CA, Adams MR, Kaplan JR, Appt SE, Clarkson TB. Inflammation and atherogenesis in female cynomolgus macaques (Macaca fascicularis) [abstract]. Am J Primatol. 2007;69(Suppl 1):72.

Appt SE, Kaplan JR, Clarkson TB, Hoyer PB. Modeling the perimenopausal transition [abstract]. Am J Primatol. 2007;69(Suppl 1):72-73.

Shively CA, Register TC, Adams MR, Golden DL, Willard SL, Clarkson TB. Depression and coronary artery atherosclerosis in adult female Macaca fascicularis [abstract]. Am J Primatol. 2007;69(Suppl 1):73.

Tormala RM, Appt S, Clarkson TB, Groop P-H, Ronnback M, Ylikorkala O, Mikkola TS. Equol production capability is associated with favorable end function in postmenopausal women using tibolone [abstract]. Atheroscler Suppl. 2007;8(1):116-117.

Jones JC, Appt SE, Bourland JD, Hoyer PB, Clarkson TB, Kaplan JR. Multidetector computed tomographic morphology of ovaries in cynomolgus macaques (Macaca fascicularis). J Am Assoc Lab Anim Sci. 2007;46(5):54-63.

Appt SE, Kaplan JR, Clarkson TB, Hoyer PB, Arifin E, Cline M, Isom S. Intramuscular administration of 4-vinylcyclohexene diepoxide (VCD) destroys primordial follicles in adult Sprague Dawley rats (Rattus norvegicus) [abstract]. J Am Assoc Lab Anim Sci. 2007;46(4):133-134.

Clarkson TB, Kaplan JR. Stage of reproductive life, atherosclerosis progression and estrogen effects on coronary artery atherosclerosis In: Lobo RA, ed. Treatment of the postmenopausal woman: basic and clinical aspects. 3rd ed. Burlington (MA): Academic Press;2007: 509-528.


Tormal RM, Appt S, Clarkson TB, Tikkanen MJ, Ylikorkala O, Mikkola TS. Individual differences in equol production capability modulate blood pressure in tibolone-treated postmenopausal women: lack of effect of soy supplementation. Climacteric. 2007;10(6):471-479.

Appt SE, Clarkson TB, Lees CJ, Anthony MS. Low dose estrogens inhibit coronary artery atherosclerosis in postmenopausal monkeys. Maturitas. 2006;55(2):187-194.


Wood CE, Appt SE, Clarkson TB, Franke AA, Lees CJ, Doerge DR, Cline JM. Effects of high-dose soy lsoflavones and equol on reproductive tissues in female cynomolgus monkeys. Biol Reprod. 2006;75(3):477-486.

Kaplan JR, Adams MR, Clarkson TB. Monkeys and the postmenopausal hormone therapy conundrum [abstract]. Am J Primatol. 2006;68(Suppl 1):39.

Shively CA, Register TC, Friedman DP, Gage HD, Bounds MC, Clarkson TB. Neurobiological substrates of a relationship between depression and atherosclerosis in adult female cynomolgus monkeys (Macaca fascicularis) [abstract]. Am J Primatol. 2006;68(Suppl 1):36-37.

Wood CE, Clarkson TB, Appt SE, Franke AA, Boue SM, Burow ME, McCoy T, Cline JM. Effects of soybean glyceollins and estradiol in postmenopausal female monkeys. Nutr Cancer. 2006;56(1):74-81.

Clarkson TB. Estrogen effects on arteries vary with stage of reproductive life and extent of subclinical atherosclerosis progression [abstract]. Menopause. 2006;13(6):981.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Pathology-Comparative Medicine

Clinical Specialties

Hormone Replacement Therapy and Menopause, Atherosclerosis

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