J. Mark Cline, D.V.M., Ph.D.Wake Forest School of Medicine

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Education & Training

  • B.S., North Carolina State University, 1982
  • D.V.M., North Carolina State University, 1986
  • Ph.D., North Carolina State University, 1992
  • Internship, Pathology - Anatomic, New York State College Veterna, 1987
  • Residency, Pathology - Anatomic, New York State College Veterna, 1988


  • Am Assn Of Cancer Research
  • Radiation Research Society
  • Soc for Toxicologic Pathology
  • Veterinary Cancer Society
  • Am Coll Of Veterinary Patholog
  • Am Veterinary Medical Assn
  • DVM Foun Adv of Vet & Com Path
J. Mark Cline, D.V.M., Ph.D.

J. Mark Cline, D.V.M., Ph.D.

Section Head, Pathology-Comparative Medicine
Professor, Pathology-Comparative Medicine
Comprehensive Cancer Center
Hypertension and Vascular Research Center
Office of Women in Medicine and Science
Center for Comparative Medicine Research
Center for Integrative Medicine
Translational Science Institute

Research Interests

aging, biotechnology, cancer/oncogenesis, cardiac function, cross(mult/tnslat/inter)discip, diabetes, drugs/therapeutic agents pharm, education/training (all f, t,, genetics/genome, immunology/allergy/inflammatio, infectious diseases, medical technology/devices, model development, nuclear medicine, radiology imaging/nuclear medi, surgery/trauma/burns/trauma

Contact Information

Academic: 336-716-1564 | Department: 336-716-1564


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Recent Publications

Maglic D, Stovall DB, Cline JM, Fry EA, Mallakin A, Taneja P, Caudell DL, Willingham MC, Sui G, Inoue K. DMP1beta, a splice isoform of the tumour suppressor DMP1 locus, induces proliferation and progression of breast cancer. J Pathol. 2015;236(1):90-102.

Williams JK, Eckman D, Dean A, Moradi M, Allickson J, Cline JM, Yoo JJ, Atala A. The dose-effect safety profile of skeletal muscle precursor cell therapy in a dog model of intrinsic urinary sphincter deficiency. Stem Cells Transl Med. 2015;4(3):286-294.

Fang X, Gyabaah K, Nickkholgh B, Cline JM, Balaji KC. Novel in vivo model for combinatorial fluorescence labeling in mouse prostate. Prostate. 2015;75(9):988-1000.

Kavanagh K, Dendinger MD, Davis AT, Register TC, DeBo R, Dugan G, Cline JM. Type 2 diabetes is a delayed late effect of whole-body irradiation in nonhuman primates. Radiat Res. 2015;183(4):398-406.

Hanbury DB, Robbins ME [deceased], Bourland JD, Wheeler KT, Peiffer AM, Mitchell EL, Daunais JB, Deadwyler SA, Cline JM. Pathology of fractionated whole-brain irradiation in rhesus monkeys (Macaca mulatta). Radiat Res. 2015;183(3):367-374.

DeBo RJ, Register TC, Caudell DL, Sempowski GD, Dugan G, Gray S, Owzar K, Jiang C, Bourland JD, Chao NJ, Cline JM. Molecular and cellular profiling of acute responses to total body radiation exposure in ovariectomized female cynomolgus macaques. Int J Radiat Biol. 2015;91(6):510-518.

Willson CJ, Herbert RA, Cline JM. Hormone receptor expression in spontaneous uterine adenocarcinoma in Fischer 344 rats. Toxicol Pathol. 2015;43(6):865-871.

Cline JM, Dixon D, Ernerudh J, Faas MM, Gohner C, Hager JD, Markert UR, Pfarrer C, Svensson-Arvelund J, Buse E. The placenta in toxicology. Part III: pathologic assessment of the placenta. Toxicol Pathol. 2014;42(2):339-344.

Hernandez-Ramon EE, Sandoval NA, John K, Cline JM, Wood CE, Woodward RA, Poirier MC. Tamoxifen-DNA adduct formation in monkey and human reproductive organs. Carcinogenesis. 2014;35(5):1172-1176.

Sharma A, Fonseca LL, Rajani C, Yanagida JK, Endo Y, Cline JM, Stone JC, Ji J, Ramos JW, Lorenzo PS. Targeted deletion of RasGRP1 impairs skin tumorigenesis. Carcinogenesis. 2014;35(5):1084-1091.

Buse E, Haeger JD, Svensson-Arvelund J, Markert UR, Faas MM, Ernerudh J, Dixon D, Cline JM, Pfarrer C. The placenta in toxicology. Part I: animal models in toxicology: placental morphology and tolerance molecules in the cynomolgus monkey (Macaca fascicularis). Toxicol Pathol. 2014;42(2):314-326.

Gohner C, Svensson-Arvelund J, Pfarrer C, Hager JD, Faas M, Ernerudh J, Cline JM, Dixon D, Buse E, Markert UR. The placenta in toxicology. Part IV: battery of toxicological test systems based on human placenta. Toxicol Pathol. 2014;42(2):345-351.

Svensson-Arvelund J, Ernerudh J, Buse E, Cline JM, Haeger JD, Dixon D, Markert UR, Pfarrer C, De Vos P, Faas MM. The placenta in toxicology. Part II: systemic and local immune adaptations in pregnancy. Toxicol Pathol. 2014;42(2):327-338.

Dugan G, O'Donnell L, Hanbury DB, Cline JM, Caudell DL. Assessment of multiplate platelet aggregometry using citrate, heparin or hirudin in rhesus macaques. Platelets. 2014;():.

Noser L, Cline JM, Chou J, Stute P. Angiogenesis gene expression across different life stages in non-human primates (Macaca fascicularis) in normal and cancerous mammary gland - an exploratory study [abstract]. Menopause. 2014;21(12):1339.

Sadri-Ardekani H, Sohutskay D, Cline JM, Atala A. Xenotransplantation model of human Spermatogonial Stem Cells (SSCs) to cynomolgus monkeys' testes-a feasibility study [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S78.

Williams J, Eckman D, Dean A, Allikson J, Cline J, Yoo J, Atala A. Safety of skeletal muscle precursor cell therapy in a dog model of urethral sphincter deficiency [abstract]. Tissue Eng Part A. 2014;20(Suppl 1):S18-S19.

Evers S, Garg PK, Cline JM, Garg S, Dugan G, Freimoser-Grundschober A, Keirstead ND, Klein C, Nayak T. Tumor targeting and pharmacodynamics of the novel targeted immunocytokine FAP-IL2v in a tumor-bearing Rhesus monkey [abstract]. Cancer Res. 2014;74(19 Suppl):A2592.

Feneran AN, O'Donnell R, Press A, Yosipovitch G, Cline M, Dugan G, Papoiu AD, Nattkemper LA, Chan YH, Shively CA. Monkey see, monkey do: contagious itch in nonhuman primates. Acta Derm Venereol. 2013;93(1):27-29.

Shelton KA, Cline JM, Cann JA. 17-beta estradiol reduces atherosclerosis without exacerbating lupus in ovariectomized systemic lupus erythematosus-susceptible LDLr(-/-) mice. Atherosclerosis. 2013;227(2):228-235.

Hassan S, Karpova Y, Baiz D, Yancey D, Pullikuth A, Flores A, Register T, Cline JM, D'Agostino R Jr, Danial N, Datta SR, Kulik G. Behavioral stress accelerates prostate cancer development in mice. J Clin Invest. 2013;123(2):874-886.

Morimoto Y, Killeen J, Hernandez BY, Cline JM, Maskarinec G. Parity and expression of epithelial histopathologic markers in breast tissue. Eur J Cancer Prev. 2013;22(5):404-408.

Ethun KF, Wood CE, Cline JM, Register TC, Appt SE, Clarkson TB. Endometrial profile of bazedoxifene acetate alone and in combination with conjugated equine estrogens in a primate model. Menopause. 2013;20(7):777-784.

Dewi FN, Wood CE, Lees CJ, Willson CJ, Register TC, Tooze JA, Franke AA, Cline JM. Dietary soy effects on mammary gland development during the pubertal transition in nonhuman primates. Cancer Prev Res (Phila Pa). 2013;6(8):832-842.

Granfeldt A, Shi W, Schmarkey SL, Jiang R, Bone CC, Cline JM, Wogensen L, Dobson GP, Tonnesen E, Vinten-Johansen J. The effects of adenocaine (adenosine and lidocaine) on early post-resuscitation cardiac and neurological dysfunction in a porcine model of cardiac arrest. Resuscitation. 2013;84(11):1611-1618.

Down JD, Medhora M, Jackson IL, Cline JM, Vujaskovic Z. Do variations in mast cell hyperplasia account for differences in radiation-induced lung injury among different mouse strains, rats and nonhuman primates? [commentary]. Radiat Res. 2013;180(2):216-221.

Wood CE, Boue SM, Collins-Burow BM, Rhodes LV, Register TC, Cline JM, Dewi FN, Burow ME. Glyceollin-elicited soy protein consumption induces distinct transcriptional effects as compared to standard soy protein. J Agric Food Chem. 2012;60(1):81-86.

Feneran AN, O'Donnell R, Press A, Yosipovitch G, Cline M, Dugan G, Papoiu A, Nattkemper L, Chan Y, Shively CA. Monkey see, monkey do: contagious itch in nonhuman primates [abstract]. J Invest Dermatol. 2012;132(Suppl 1):S39.

Hulchiy M, Zhang H, Cline JM, Hirschberg AL, Sahlin L. Effects of long-term tibolone treatment on nuclear sex steroid hormone receptors and G-protein-coupled estrogen receptor-1 expression in the macaque uterus. Menopause. 2012;19(3):332-338.

Wu M, Shi L, Cimic A, Romero L, Sui G, Lees CJ, Cline JM, Seals DF, Sirintrapun JS, McCoy TP, Liu W, Kim JW, Hawkins GA, Peehl DM, Xu J, Cramer SD. Suppression of Tak1 promotes prostate tumorigenesis. Cancer Res. 2012;72(11):2833-2843.

Cline JM, Brignolo L, Ford EW. Urogenital system In: Abee CR, Mansfield K, Tardif S, Morris T, eds. Nonhuman primates in biomedical research: diseases, vol 2. 2nd ed. Boston: Elsevier/Academic Press;2012: 483-562.

Clafshenkel WP, King TL, Kotlarczyk MP, Cline JM, Foster WG, Davis VL, Witt-Enderby PA. Morinda citrifolia (noni) juice augments mammary gland differentiation and reduces mammary tumor growth in mice expressing the unactivated c-erbB2 transgene. Evid Based Complement Alternat Med. 2012;2012():487423.

Stute P, Sielker S, Wood CE, Register TC, Lees CJ, Dewi FN, Williams JK, Wagner JD, Stefenelli U, Cline JM. Life stage differences in mammary gland gene expression profile in non-human primates. Breast Cancer Res Treat. 2012;133(2):617-634.

Schnatz PF, Nudy M, O'Sullivan DM, Jiang X, Cline JM, Kaplan JR, Clarkson TB, Appt SE. Coronary artery vitamin D receptor expression and plasma concentrations of 25-hydroxyvitamin D: their association with atherosclerosis. Menopause. 2012;19(9):967-973.

Dewi FN, Wood CE, Lampe JW, Hullar MAJ, Franke AA, Golden DL, Adams MR, Cline JM. Endogenous and exogenous equol are antiestrogenic in reproductive tissues of apolipoprotein E-null mice. J Nutr. 2012;142(10):1829-1835.

Johnson NA, Ho A, Cline JM, Hughes CL, Foster WG, Davis VL. Accelerated mammary tumor onset in a HER2/Neum mouse model exposed to DDT metabolites locally delivered to the mammary gland. Environ Health Perspect. 2012;120(8):1170-1176.

Hulchiy M, Zhang H, Cline JM, Hirschberg AL, Sahlin L. Receptors for thyrotropin-releasing hormone, thyroid-stimulating hormone, and thyroid hormones in the macaque uterus: effects of long-term sex hormone treatment. Menopause. 2012;19(11):1253-1259.

Schnatz PF, Nudy M, O'Sullivan DM, Jiang X, Cline JM, Kaplan JR, Clarkson TB, Appt SE. The quantification of vitamin D receptors in coronary arteries and their association with atherosclerosis. Maturitas. 2012;73(2):143-147.

Ethun KF, Wood CE, Register TC, Cline JM, Appt SE, Clarkson TB. Effects of bazedoxifene acetate with and without conjugated equine estrogens on the breast of postmenopausal monkeys. Menopause. 2012;19(11):1242-1252.

Robbins ME, Bourland JD, Cline JM, Wheeler KT, Deadwyler SA. A model for assessing cognitive impairment after fractionated whole-brain irradiation in nonhuman primates. Radiat Res. 2011;175(4):519-525.

Wood CE, Tannehill-Gregg SH, Chen Z, van Doorslaer K, Nelson DR, Cline JM, Burk RD. Novel betapapillomavirus associated with hand and foot papillomas in a cynomolgus macaque. Vet Pathol. 2011;48(3):731-736.

Willard SL, Daunais JB, Cline JM, Shively CA. Hippocampal volume in postmenopausal cynomolgus macaques with behavioral depression. Menopause. 2011;18(5):582-586.

Clarkson TB, Utian WH, Allmen TI, Aso T, Barnes S, Basaria SS, Brinton RD,. The role of soy isoflavones in menopausal health: report of The North American Menopause Society/Wulf H. Utian Translational Science Symposium in Chicago, IL (October 2010). Menopause. 2011;18(7):732-753.

Zhang H, von Schoultz B, Cline JM, Sahlin L. Distribution of cyclooxygenases 1 and 2 in the uterus and breast of cynomolgus monkeys--effects of hormone treatment. Menopause. 2011;18(9):1001-1009.

Hill GD, Moore AB, Kissling GE, Flagler ND, Ney E, Cline JM, Dixon D. Effects of hormonally active agents on steroid hormone receptor expression and cell proliferation in the myometrium of ovariectomized macaques. Toxicol Pathol. 2011;39(3):508-515.

Cheng CP, Cheng H-J, Zhou P, Masutani S, Callahan MF, Cline JM, Little WC. Is beta3-adrenoceptor (AR) a target for heart failure therapy? Evidence from beta3-AR knockout mice [abstract]. Circulation. 2011;124(21 Suppl):A12986.

Ethun KF, Cline JM, Appt SE. Endocrine profile of an ovariectomized cynomolgus monkey (Macaca fascicularis) with a supernumerary ovary. Comp Med. 2011;61(5):462-466.

Wood CE, Kaplan JR, Fontenot MB, Williams JK, Cline JM. Endometrial profile of tamoxifen and low-dose estradiol combination therapy. Clin Cancer Res. 2010;16(3):946-956.

Shahryarinejad A, Gardner TR, Cline JM, Levine WN, Bunting HA, Brodman MD, Ascher-Walsh CJ, Scotti RJ, Vardy MD. Effect of hormone replacement and selective estrogen receptor modulators (SERMs) on the biomechanics and biochemistry of pelvic support ligaments in the cynomolgus monkey (Macaca fascicularis). Am J Obstet Gynecol. 2010;202(5):485.e1-9.

Chen BJ, Deoliveira D, Spasojevic I, Sempowski GD, Jiang C, Owzar K, Wang X, Cline JM, Bourland JD, Dugan G, et al. Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates. PLoS ONE. 2010;5(6):e11056.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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