Profile

Robert C. Coghill, Ph.D.Wake Forest School of Medicine

Robert C. Coghill, Ph.D.

Professor,

Anesthesiology
Anesthesiology

Clinical Specialties

Pain Research, Advanced MRI Methods

Contact Information

Academic: 336-716-4284 | Department: 336-716-4284

Email: rcoghill@wakehealth.edu

Related Links

Education & Training

  • B.S., College of William & Mary , 1986
  • Ph.D., Virginia Commonwealth University , 1991
  • Fellowship, University Montreal Med-Canada, 1993
Robert C. Coghill, Ph.D.

Robert C. Coghill, Ph.D.

Professor, Neurobiology & Anatomy
Center for Integrative Medicine
Anesthesiology
Anesthesiology

Research Interests

pain, radiology/imaging

Contact Information

Academic: 336-716-4284 | Department: 336-716-4284

Email: rcoghill@wakehealth.edu

Related Links

Recent Publications

Lobanov OV, Zeidan F, McHaffie JG, Kraft RA, Coghill RC. From cue to meaning: brain mechanisms supporting the construction of expectations of pain. Pain. 2014;155(1):129-136.

Emerson NM, Zeidan F, Lobanov OV, Hadsel MS, Martucci KT, Quevedo AS, Starr CJ, Nahman-Averbuch H, Weissman-Fogel I, Granovsky Y, Yarnitsky D, Coghill RC. Pain sensitivity is inversely related to regional grey matter density in the brain. Pain. 2014;155(3):566-573.

Zeidan F, Martucci KT, Kraft RA, McHaffie JG, Coghill RC. Neural correlates of mindfulness meditation-related anxiety relief. Soc Cogn Affect Neurosci. 2014;9(6):751-759.

Emerson N, Zeidan F, Lobanov O, Hadsel M, Martucci K, Quevedo A, Starr C, Nahman-Averbuch H, Weissman-Fogel I, Granovsky Y, Yarnitsky D, Coghill R. Regional grey matter density in the brain is related to pain sensitivity in healthy individuals [abstract]. J Pain. 2014;15(4 Suppl 1):S56.

Papoiu AD, Emerson NM, Patel TS, Kraft RA, Valdes-Rodriguez R, Nattkemper LA, Coghill RC, Yosipovitch G. Voxel-based morphometry and arterial spin labeling fMRI reveal neuropathic and neuroplastic features of brain processing of itch in end-stage-renal-disease. J Neurophysiol. 2014;():.

Zeidan F, Emerson N, Farris S, Ray J, McHaffie J, Coghill R. Does mindfulness meditation-related pain relief engage distinct brain mechanisms from placebo analgesia? [abstract]. Psychosom Med. 2014;76(3):A60.


Zeidan F, Lobanov OV, Kraft RA, Coghill RC. Brain mechanisms evaluating the discordance between expectated and experienced pain [abstract]. In: Abstracts of the 14th World Congress on Pain; 2012 Aug 27-31; Milan (Italy). 2013;():PT 502.

Nahman-Averbuch H, Martucci KT, Granovsky Y, Weissman-Fogel I, Yarnitsky D, Coghill RC. Different patterns of brain activation during conditioned pain modulation and offset analgesia [abstract]. In: Abstracts of the 14th World Congress on Pain; 2012 Aug 27-31; Milan (Italy). 2013;():PH 314.

Emerson NM, Hadsel MS, Lobanov OV, Martucci KT, Quevedo AS, Starr CJ, Zeidan F, Hanman-Averbuch H, Weissman-Fogel I, Granovsky Y, Coghill RC. Pain sensitivity is inversely related to grey matter volume in brain areas associated with the default mode network [abstract]. In: Abstracts of the 14th World Congress on Pain; 2012 Aug 27-31; Milan (Italy). 2013;():PH 301.

Lobanov OV, Zeidan F, Kraft RA, Coghill RC. Brain mechanisms engaged by expectation of pain: common patterns of activity from cues of different modalitites [abstract]. In: Abstracts of the 14th World Congress on Pain; 2012 Aug 27-31; Milan (Italy). 2013;():PH 307.

Papoiu AD, Nattkemper L, Kraft R, Coghill R, Yosipovitch G. Differential effect of butorphanol on histamine itch, cowhage itch and heat pain sensitivity. A combined psychophysical and neuroimaging study [abstract]. J Invest Dermatol. 2013;133(Suppl 1):S188.

Nahman-Averbuch H, Granovsky Y, Coghill RC, Yarnitsky D, Sprecher E, Weissman-Fogel I. Waning of 'conditioned pain modulation': a novel expression of subtle pronociception in migraine. Headache. 2013;53(7):1104-1115.

Lobanov OV, Quevedo AS, Hadsel MS, Kraft RA, Coghill RC. Frontoparietal mechanisms supporting attention to location and intensity of painful stimuli. Pain. 2013;154(9):1758-1768.

Papoiu AD, Nattkemper LA, Sanders KM, Kraft RA, Chan YH, Coghill RC, Yosipovitch G. Brain's reward circuits mediate itch relief. A functional MRI study of active scratching. PLoS One. 2013;8(12):e82389.


Papoiu ADP, Coghill RC, Kraft RA, Wang H, Yosipovitch G. A tale of two itches. Common features and notable differences in brain activation evoked by cowhage and histamine induced itch. Neuroimage. 2012;59(4):3611-3623.

Martucci K, Eisenach J, North J, Rauck R, Tong C, Wilson K, Coghill R. Offset analgesia in complex regional pain syndrome [abstract]. J Pain. 2012;13(4 Suppl):S47.

Martucci KT, Eisenach JC, Tong C, Coghill RC. Opioid-independent mechanisms supporting offset analgesia and temporal sharpening of nociceptive information. Pain. 2012;153(6):1232-1243.

Papoiu AD, Nattkemper L, Coghill R, Yosipovitch G. Visualizing the brain processing of the itch-scratch cycle by functional MRI [abstract]. J Invest Dermatol. 2012;132(Suppl 1):S94.

Zeidan F, Grant JA, Brown CA, McHaffie JG, Coghill RC. Mindfulness meditation-related pain relief: evidence for unique brain mechanisms in the regulation of pain. Neurosci Lett. 2012;520(2):165-173.

Martucci KT, Coghill RC. Regional anesthesia: functional implications beyond the anesthetized nerve [editorial]. Anesthesiology. 2011;114(1):21-23.

Papoiu ADP, Tey HL, Coghill RC, Wang H, Yosipovitch G. Cowhage-induced itch as an experimental model for pruritus. A comparative study with histamine-induced itch. PLoS ONE. 2011;6(3):e17786.

Papoiu AD, Coghill R, Banari L, Kraft R, Yosipovitch G. Functional MRI investigations of brain processing of itch sensation in end-stage-renal-disease patients with chronic pruritus [abstract]. J Invest Dermatol. 2011;131(Suppl 1):S91.

Zeidan F, Martucci KT, Kraft RA, Gordon NS, McHaffie JG, Coghill RC. Brain mechanisms supporting the modulation of pain by mindfulness meditation. J Neurosci. 2011;31(14):5540-5548.

Papoiu ADP, Wang H, Coghill RC, Chan Y-H, Yosipovitch G. Contagious itch in humans: a study of visual 'transmission' of itch in atopic dermatitis and healthy subjects. Br J Dermatol. 2011;164(6):1299-1303.

Starr CJ, Sawaki L, Wittenberg GF, Burdette JH, Oshiro Y, Quevedo AS, McHaffie JG, Coghill RC. The contribution of the putamen to sensory aspects of pain: insights from structural connectivity and brain lesions. Brain. 2011;134(Pt 7):1987-2004.

Papoiu A, Coghill R, Kraft R, Yosipovitch G. Differential processing of cowhage and histamine itch in health and disease. Insights into brain processing of chronic pruritus revealed by arterial spin labeling FMRI [abstract]. Acta Derm Venereol. 2011;91(5):623.

Nahman-Averbuch H, Granovsky Y, Coghill R, Yarnitsky D, Weissman-Fogel I. Waning of 'conditioned pain modulation' over time: a novel manifestation of pro-nociception in migraine [abstract]. Eur J Pain Suppl. 2011;5(Suppl 1):112.

Zeidan F, McHaffie J, Kraft R, Martucci K, Coghill R. Brain mechanisms associated with meditation-induced regulation of anxiety [abstract]. In: Human Brain Mapping 17th Annual Meeting Abstracts; 2011 June 26-30; Quebec City (Canada). 2011;():391.

Steen M, Hayasaka S, Lobanov O, Laurienti P, Coghill R. Individual differences in brain networks during pain processing: a method for assessing modularity [abstract]. In: Human Brain Mapping 17th Annual Meeting Abstracts; 2011 June 26-30; Quebec City (Canada). 2011;():774.

Papoiu A, Coghill R, Banari L, Kraft R, Yosipovitch G. Insights into brain processing of acute and chronic itch revealed by arterial spin labeled MRI [abstract]. In: Human Brain Mapping 17th Annual Meeting Abstracts; 2011 June 26-30; Quebec City (Canada). 2011;():614.


Quevedo A, Morch C, Andersen O, Coghill R. Spatial summation of pain: a sub-additive phenomenon [abstract]. J Pain. 2010;11(4 Suppl 1):S33.

Martucci K, Eisenach J, Tong C, Coghill R. Early and delayed effects of intravenous administration of remifentanil and naloxone on sensitivity to thermal stimuli [abstract]. J Pain. 2010;11(4 Suppl 1):S31.

Lobanov O, Quevedo A, Kraft R, Coghill R. Brain mechanisms supporting attention to sensory features of pain [abstract]. In: 16th Annual Meeting of the Organization for Human Brain Mapping; 2010 June 6-10; Barcelona (Spain). 2010;():1431.

Papoiu AD, Wang H, Coghill RC, Yosipovitch G. Modulation of pruritus by visual stimuli. Atopic eczema patients display intensified itch perception and scratching in comparison to healthy controls when exposed to visual imagery of itch [abstract]. J Invest Dermatol. 2010;130(Suppl 1):S56.

Yosipovitch G, Papoiu AD, Coghill RC, Wang H, Kraft RA. A comparative fMRI study of brain activation patterns induced by cowhage and histamine itch in atopic eczema patients vs. healthy subjects [abstract]. J Invest Dermatol. 2010;130(Suppl 1):S56.

Morch CD, Andersen OK, Quevedo AS, Arendt-Nielsen L, Coghill RC. Exteroceptive aspects of nociception: insights from graphesthesia and two-point discrimination. Pain. 2010;151(1):45-52.

Starr CJ, Houle TT, Coghill RC. Psychological and sensory predictors of experimental thermal pain: a multifactorial model. J Pain. 2010;11(12):1394-1402.


Zeidan F, Martucci KT, Kraft RA, McHaffie JG, Gordon NS, Coghill RC. Brain mechanisms associated with meditation related pain relief [abstract]. Soc Neurosci Abstr. 2010;2010(Neuroscience Meeting Planner):.

Hadsel MS, Quevedo A, Oshiro Y, Houle TT, Kraft RA, Coghill RC. Effect of anxiety-proneness on nucleus accumbens activity during noxious stimulation: a psychophysical and functional magnetic resonance imaging study [abstract]. Soc Neurosci Abstr. 2010;2010(Neuroscience Meeting Planner):.

Zeidan F, Martucci KT, Kraft RA, McHaffie JG, Gordon NS, Coghill RC. Activation of pain modulatory brain regions following brief meditation training [abstract]. In: Abstracts of the 13th World Congress on Pain; 2010 Aug 29 - Sept 2; Montreal, Quebec (Canada). 2010;():abstr 441.

Martucci KT, Eisenach JC, Tong C, Coghill RC. Paradoxical increases in offset analgesia during acute opioid induced hypersensitivity [abstract]. In: Abstracts of the 13th World Congress on Pain; 2010 Aug 29 - Sept 2; Montreal, Quebec (Canada). 2010;():abstr 225.

Yelle MD, Coghill RC. Potentiation and reversibility of offset analgesia: further insights into the temporal processing of nociceptive information [abstract]. In: Abstracts of the 13th World Congress on Pain; 2010 Aug 29 - Sept 2; Montreal, Quebec (Canada). 2010;():abstr 287.

Quevedo AS, Moerch CD, Andersen OK, Coghill RC. Modulation of spatial summation of pain by stimulus features and cognitive task [abstract]. In: Abstracts of the 13th World Congress on Pain; 2010 Aug 29 - Sept 2; Montreal, Quebec (Canada). 2010;():abstr 288.

Lobanov OV, Quevedo AS, Hadsel MS, Kraft RA, Coghill RC. Brain mechanisms engaged by discrimination of sensory features of pain [abstract]. In: Abstracts of the 13th World Congress on Pain; 2010 Aug 29 - Sept 2; Montreal, Quebec (Canada). 2010;():abstr 237.

Starr CJ, Sawaki L, Wittenberg GF, Burdette JH, Oshiro Y, Quevedo AS, Coghill RC. Roles of the insular cortex in the modulation of pain: insights from brain lesions. J Neurosci. 2009;29(9):2684-2694.

Wang H, Papoiu A, Coghill R, Patel T, Yosipovitch G. African Americans display a significant lack of hyperalgesia and neurogenic inflammation in response to topical capsaicin [abstract]. J Invest Dermatol. 2009;129(Suppl 1):S52.

Martucci K, Coghill R, Yelle M. Heat-induced thermal hyperalgesia and the capsaicin-heat sensitization model [abstract]. J Pain. 2009;10(4 Suppl 1):S25.

Quevedo A, Tong C, Coghill R. Offset analgesia is disrupted during delayed hypersensitivity following clonidine administration [abstract]. J Pain. 2009;10(4 Suppl 1):S26.

Hadsel M, Quevedo A, Oshiro Y, Houle T, Schmidt J, Stapleton J, Kraft R, Coghill R. Interrelationships between anxiety proneness and central autonomic processing during pain: a psychophysical and functional magnetic resonance imaging (fMRI) study [abstract]. J Pain. 2009;10(4 Suppl 1):S27.

Shute K, Coghill R. Dynamic modulation of the relationship between stimulus temperature and heat pain by the rate of temperature increase [abstract]. J Pain. 2009;10(4 Suppl 1):S31.

Yelle MD, Oshiro Y, Kraft RA, Coghill RC. Temporal filtering of nociceptive information by dynamic activation of endogenous pain modulatory systems. J Neurosci. 2009;29(33):10264-71.

Coghill RC. Pain: neuroimaging In: Squire LR, ed. Encyclopedia of neuroscience, vol 7. Boston: Elsevier Academic Press;2009: 409-414.

Lawson HC, Ohara S, Greenspan JD, Coghill RC, Lenz FA. Neurophysiology of cingulate pain responses and neurosurgical pain interventions In: Vogt BA, ed. Cingulate neurobiology and disease. New York: Oxford University Press;2009: 401-417.

Martucci KT, Eisenach JC, Tong C, Coghill RC. Comparison of heat hyperalgesia following intravenous administration of naloxone and remifentanil [abstract]. Soc Neurosci Abstr. 2009;2009(Neuroscience Meeting Planner):.

Ishiuji Y, Coghill RC, Patel TS, Oshiro Y, Kraft RA, Yosipovitch G. Distinct patterns of brain activity evoked by histamine-induced itch reveal an association with itch intensity and disease severity in atopic dermatitis. Br J Dermatol. 2009;161(5):1072-1080.

Oshiro Y, Quevedo AS, McHaffie JG, Kraft RA, Coghill RC. Brain mechanisms supporting discrimination of sensory features of pain: a new model. J Neurosci. 2009;29(47):14924-1431.


Papoiu ADP, Coghill RC, Wang H, Kraft RA, Yosipovitch G. A tale of two itches: common features and notable differences in brain activation revealed in a comparative fMRI study of cowhage and histamine induced itch [abstract]. Acta Derm Venereol. 2009;89(6):692.

Yelle MD, Rogers JM, Coghill RC. Offset analgesia: a temporal contrast mechanism for nociceptive information. Pain. 2008;134(1-2):174-186.

Ishiuji Y, Coghill RC, Patel TS, Dawn A, Fountain J, Oshiro Y, Yosipovitch G. Repetitive scratching and noxious heat do not inhibit histamine-induced itch in atopic dermatitis. Br J Dermatol. 2008;158(1):78-83.

Ishiuji Y, Coghill RC, Patel T, Kraft RA, Oshiro Y, Yosipovitch G. The brain processing of scratching in patients with atopic eczema [abstract]. J Invest Dermatol. 2008;128(Suppl 1):S13.

Yosipovitch G, Ishiuji Y, Patel TS, Hicks MI, Oshiro Y, Kraft RA, Winnicki E, Coghill RC. The brain processing of scratching. J Invest Dermatol. 2008;128(7):1806-1811.

Hadsel M, Quevedo A, Oshiro Y, Kraft R, Coghill R. Anxiety-proneness modulates pain-induced brain activation: insights from an independent component analysis (ICA) [abstract]. J Pain. 2008;9(4 Suppl 1):P11.

Quevedo A, Coghill R. Cognitive modulation of radiation of pain [abstract]. J Pain. 2008;9(4 Suppl 1):P12.


Hadsel MS, Quevedo A, Oshiro Y, Houle TT, McHaffie JG, Kraft RA, Coghill RC. Precuneus/posterior cingulate cortex activity in experimental pain--a functional magnetic resonance imaging (FMRI) study [abstract]. In: Abstracts of the 12th World Congress on Pain [on CD]. 2008;():PF 139.

Starr CJ, Sawaki L, Wittenberg GF, Burdette JH, Oshiro Y, Quevedo AS, Coghill RC. Effects of basal ganglia lesions on pain and pain-related brain activations [abstract]. In: Abstracts of the 12th World Congress on Pain [on CD]. 2008;():PH 118.

Martucci KT, Yelle MD, Coghill RC. Altered temporal sharpening of nociceptive information following heat-capsaicin sensitization [abstract]. In: Abstracts of the 12th World Congress on Pain [on CD]. 2008;():PT 085.

Oshiro Y, Jordan SB, Sintay BJ, Eisenach JC, Coghill RC. Psychophysical differences between mechanical pressure pain and heat pain [abstract]. In: Abstracts of the 12th World Congress on Pain [on CD]. 2008;():PM 266.

Morch CD, Andersen OK, Coghill RC. Graphesthesia and two-point discrimination of painful heat stimulation [abstract]. In: Abstracts of the 12th World Congress on Pain [on CD]. 2008;():PM 270.

Quevedo AS, Coghill RC. Modulation of spatial integration of noiceptive processing by bottom up and top down factors [abstract]. In: Abstracts of the 12th World Congress on Pain [on CD]. 2008;():PM 271.

Oshiro Y, Quevedo AS, McHaffie JG, Kraft RA, Coghill RC. Brain mechanisms supporting spatial discrimination of pain. J Neurosci. 2007;27(13):3388-3394.

Yosipovitch G, Duque MI, Fast K, Dawn AG, Coghill RC. Scratching and noxious heat stimuli inhibit itch in humans: a psychophysical study. Br J Dermatol. 2007;156(4):629-634.

Patel TS, Ishiuji Y, Coghill RC, Hicks MI, Kraft RA, Oshiro Y, Winnicki E, Yosipovitch G. The activation of brain networks during scratching [abstract]. J Invest Dermatol. 2007;127(Suppl 1):S6.

Quevedo AS, Coghill RC. An illusion of proximal radiation of pain due to distally directed inhibition. J Pain. 2007;8(3):280-286.

Hadsel M, Oshiro Y, Quevedo A, Kraft R, Coghill R. Relationship between anxiety, perceived pain and pain-related brain activation [abstract]. J Pain. 2007;8(4 Suppl):S15.

Starr C, Houle T, Coghill R. Multifactorial predictors of experimental thermal pain [abstract]. J Pain. 2007;8(4 Suppl):S18.


Veldhuijzen DS, Greenspan JD, Kim JH, Coghill RC, Treede RD, Ohara S, Lenz FA. Imaging central pain syndromes. Curr Pain Headache Rep. 2007;11(3):183-189.

Coghill RC. The encoding of noxious information in the spinal cord In: Schmidt RF, Willis WD, eds. Encyclopedia of pain. Berlin: Springer;2007: 660-696.

Ishiuji Y, Patel T, Coghill RC, Hicks MI, Kraft R, Oshiro Y, Winnicki E, Yosipovitch G. The activation of brain networks during scratching [abstract]. Acta Derm Venereol. 2007;87(5):475-476.

Quevedo AS, Coghill RC. Attentional modulation of spatial integration of pain: evidence for dynamic spatial tuning. J Neurosci. 2007;27(43):11635-40.

Ishiuji Y, Coghill RC, Patel T, Kraft RA, Oshiro Y, Yosipovitch G. Itch-related brain activity in patients with atopic eczema [abstract]. J Invest Dermatol. 2007;127(Suppl 1):S8.

Ishiuji Y, Coghill RC, Patel T, Kraft RA, Oshiro Y, Yosipovitch G. The brain processing of pruritis in atopic dermatitis [abstract]. Acta Derm Venereol. 2007;87(Suppl 5):476.

Starr C, Sawaki L, Wittenberg G, Burdette J, Oshiro Y, Quevedo A, Coghill R. Integrity of pain perception after lesions of the insular cortex [abstract]. Neuroimage. 2007;36(Suppl 1):S87.

Ishiuji Y, Dawn A, Fountain J, Coghill RC, Oshiro Y, Yosipovitch G. Scratching and noxious heat stimuli aggravate itch perception in atopic dermatitis [abstract]. J Invest Dermatol. 2006;126(Suppl):5.

Martucci KT, Coghill RC, Kraft RA. A new spin on chronic pain imaging: quantitative perfusion imaging using arterial spin labeling MRI [abstract]. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.

Hadsel MS, Quevedo A, Oshiro Y, Kraft RA, Coghill RC. fMRI studies of pain: not all baseline periods are equal [abstract]. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.

Yelle MD, Kraft R, Oshiro Y, Coghill RC. Neural correlates of offset analgesia [abstract]. Neuroimage. 2006;31(Suppl 1):S179.

Oshiro Y, Quevedo AS, McHaffie JG, Kraft RA, Coghill RC. Brain mechanisms supporting intensity discrimination and memory of pain [abstract]. Neuroimage. 2006;31(Suppl 1):S179.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Neurobiology & Anatomy

Clinical Specialties

Pain Research, Advanced MRI Methods
Robert C. Coghill, Ph.D.

Robert C. Coghill, Ph.D.

Professor, Neurobiology & Anatomy
Center for Integrative Medicine
Anesthesiology
Anesthesiology

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