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Laura H. Coker, Ph.D.Wake Forest School of Medicine

Laura H. Coker, Ph.D.

Associate Professor,


Contact Information

Academic: 336-716-3324 | Department: 336-716-3324

Email: lcoker@wakehealth.edu

Education & Training

  • B.S.N., University of North Carolina-Greensboro, 1985
  • M.S.N., University of North Carolina-Greensboro, 1990
  • Ph.D., University of North Carolina-Greensboro, 1998

Memberships

  • American Academy of Neurology
  • Soc Clin Trials
  • American Nurses Association
  • Gerontological Society Of Amer
Laura H. Coker, Ph.D.

Laura H. Coker, Ph.D.

Associate Professor, Social Sciences & Health Policy
Office of Women in Medicine and Science
Neurology

Research Interests

Cognition Disorders; Cognition; Estrogens, Conjugated (USP); Magnetic Resonance Imaging; Brain
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Contact Information

Academic: 336-716-3324 | Department: 336-716-3324

Email: lcoker@wakehealth.edu

Recent Publications

GWAS for executive function and processing speed suggests involvement of the CADM2 gene. Ibrahim-Verbaas CA, Bressler J, Debette S, Schuur M, Smith AV, Bis JC, Davies G, Trompet S, Smith JA, Wolf C, Chibnik LB, Liu Y, Vitart V, Kirin M, Petrovic K, Polasek O, Zgaga L, Fawns-Ritchie C, Hoffmann P, Karjalainen J, Lahti J, Llewellyn DJ,.. Mol Psychiatry. 2016;21(2):189-197.

Hypertension, dietary sodium, and cognitive decline: results from the Women's Health Initiative Memory Study. Haring B, Wu C, Coker LH, Seth A, Snetselaar L, Manson JE, Rossouw JE, Wassertheil-Smoller S.. Am J Hypertens. 2016;29(2):202-216.

Correlates of successful aging in racial and ethnic minority women age 80 years and older: findings from the Women's Health Initiative. Cene CW, Dilworth-Anderson P, Leng I, Garcia L, Benavente V, Rosal M, Vaughan L, Coker LH, Corbie-Smith G, Kim M, Bell CL, Robinson JG, Manson JE, Cochrane B.. J Gerontol A Biol Sci Med Sci. 2016;71(Suppl 1):S87-99.

Mild cognitive impairment and dementia prevalence: the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS). Knopman DS, Gottesman RF, Sharrett AR, Wruck LM, Windham BG, Coker L, Schneider AL, Hengrui S, Alonso A, Coresh J, Albert MS, Mosley TH Jr.. Alzheimers Dement (Amst). 2016;2():1-11.

Life-course blood pressure in relation to brain volumes. Power MC, Schneider AL, Wruck L, Griswold M, Coker LH, Alonso A, Jack CR Jr, Knopman D, Mosley TH, Gottesman RF.. Alzheimers Dement. 2016;12(8):890-899.

Normative data for 8 neuropsychological tests in older blacks and whites from the Atherosclerosis Risk in Communities (ARIC) study. Schneider AL, Sharrett AR, Gottesman RF, Coresh J, Coker L, Wruck L, Selnes OA, Deal J, Knopman D, Mosley TH.. Alzheimer Dis Assoc Disord. 2015;29(1):32-44.

Caregiving frequency and physical function: the Women's Health Initiative. Rosso AL, Lee BK, Stefanick ML, Kroenke CH, Coker LH, Woods NF, Michael YL.. J Gerontol A Biol Sci Med Sci. 2015;70(2):210-215.

Vascular imaging abnormalities and cognition: mediation by cortical volume in nondemented individuals: Atherosclerosis Risk in Communities-Neurocognitive Study. Knopman DS, Griswold ME, Lirette ST, Gottesman RF, Kantarci K, Sharrett AR, Jack CR Jr, Graff-Radford J, Schneider AL, Windham BG, Coker LH, Albert MS, Mosley TH Jr.. Stroke. 2015;46(2):433-440.

Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. Debette S, Ibrahim Verbaas CA, Bressler J, Schuur M, Smith A, Bis JC, Davies G, Wolf C, Gudnason V, Chibnik LB, Yang Q, deStefano AL, de Quervain DJ, Srikanth V, Lahti J, Grabe HJ, Smith JA, Priebe L, Yu L, Karbalai N, Hayward C, Wilson JF, Campbell H,.. Biol Psychiatry. 2015;77(8):749-763.

Folate, vitamin B-6, and vitamin B-12 intake and mild cognitive impairment and probable dementia in the Women's Health Initiative Memory Study. Agnew-Blais JC, Wassertheil-Smoller S, Kang JH, Hogan PE, Coker LH, Snetselaar LG, Smoller JW.. J Acad Nutr Diet. 2015;115(2):231-241.

Obesity, insulin resistance, and incident small vessel disease on magnetic resonance imaging: Atherosclerosis Risk in Communities study. Dearborn JL, Schneider AL, Sharrett AR, Mosley TH, Bezerra DC, Knopman DS, Selvin E, Jack CR, Coker LH, Alonso A, Wagenknecht LE, Windham BG, Gottesman RF.. Stroke. 2015;46(11):3131-3136.

Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels: a randomized clinical trial. Williamson JD, Launer LJ, Bryan RN, Coker LH, Lazar RM, Gerstein HC, Murray AM, Sullivan MD, Horowitz KR, Ding J, Marcovina S, Lovato L, Lovato J, Margolis KL, Davatzikos C, Barzilay J, Ginsberg HN, Linz PE, Miller ME.. JAMA Intern Med. 2014;174(3):324-333.

Change in brain and lesion volumes after CEE therapies: the WHIMS-MRI studies. Coker LH, Espeland MA, Hogan PE, Resnick SM, Bryan RN, Robinson JG, Goveas JS, Davatzikos C, Kuller LH, Williamson JD, Bushnell CD, Shumaker SA.. Neurology. 2014;82(5):427-434.

The Montreal Cognitive Assessment (MoCA) in 8,724 SPRINT participants [abstract]. Sink KM, Chelune G, Coker L, Gaussoin S, Lerner A, Nichols L, Pajewski NM, Rapp S, Wadley V, Williamson J.. J Am Geriatr Soc. 2014;62(Suppl 1):S9-S10.

Impact of differential attrition on the association of education with cognitive change over 20 years of follow-up: the ARIC Neurocognitive Study. Gottesman RF, Rawlings AM, Sharrett AR, Albert M, Alonso A, Bandeen-Roche K, Coker LH, Coresh J, Couper DJ, Griswold ME, Heiss G, Knopman DS, Patel MD, Penman AD, Power MC, Selnes OA, Schneider AL, Wagenknecht LE, Windham BG, Wruck LM, Mosley TH.. Am J Epidemiol. 2014;179(8):956-966.

Early adult to midlife cardiovascular risk factors and cognitive function. Yaffe K, Vittinghoff E, Pletcher MJ, Hoang TD, Launer LJ, Whitmer R, Coker LH, Sidney S.. Circulation. 2014;129(15):1560-1567.

Vitamin D and subclinical cerebrovascular disease: the Atherosclerosis Risk in Communities Brain Magnetic Resonance Imaging study. Michos ED, Carson KA, Schneider AL, Lutsey PL, Xing L, Sharrett AR, Alonso A, Coker LH, Gross M, Post W, Mosley TH, Gottesman RF.. JAMA Neurol. 2014;71(7):863-871.

Midlife hypertension and 20-year cognitive change: the Atherosclerosis Risk in Communities Neurocognitive Study. Gottesman RF, Schneider AL, Albert M, Alonso A, Bandeen-Roche K, Coker L, Coresh J, Knopman D, Power MC, Rawlings A, Sharrett AR, Wruck LM, Mosley TH.. JAMA Neurol. 2014;71(10):1218-1227.

The metabolic syndrome and cognitive decline in the Atherosclerosis Risk in Communities study (ARIC).. Dearborn JL, Knopman D, Sharrett AR, Schneider AL, Jack CR Jr, Coker LH, Alonso A, Selvin E, Mosley TH, Wagenknecht LE, Windham BG, Gottesman RF.. Dement Geriatr Cogn Disord. 2014;38(5-6):337-346.

Influence of type 2 diabetes on brain volumes and changes in brain volumes: results from the Women's Health Initiative magnetic resonance imaging studies. Espeland MA, Bryan RN, Goveas JS, Robinson JG, Siddiqui MS, Liu S, Hogan PE, Casanova R, Coker LH, Yaffe K, Masaki K, Rossom R, Resnick SM.. Diabetes Care. 2013;36(1):90-97.

Do systolic BP and pulse pressure relate to ventricular enlargement?. Graff-Radford NR, Knopman DS, Penman AD, Coker LH, Mosley TH.. Eur J Neurol. 2013;20(4):720-724.

A genome-wide association study of depressive symptoms. Hek K, Demirkan A, Lahti J, Terracciano A, Teumer A, Cornelis MC, Amin N, Bakshis E, Baumert J, Ding J, Liu Y, Marciante K, Meirelles O, Nalls MA, Sun YV, Vogelzangs N, Yu L, Bandinelli S, Benjamin EJ, Bennett DA, Boomsma D,.. Biol Psychiatry. 2013;73(7):667-678.

Positive and negative affect, depression, and cognitive processes in the Cognition in the Study of Tamoxifen and Raloxifene (Co-STAR) Trial. Danhauer SC, Legault C, Bandos H, Kidwell K, Costantino J, Vaughan L, Avis NE, Rapp S, Coker LH, Naughton M, Naylor C, Terracciano A, Shumaker S.. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2013;20(5):532-552.

Migraine and white matter hyperintensities: the ARIC MRI study. Hamedani AG, Rose KM, Peterlin BL, Mosley TH, Coker LH, Jack CR, Knopman DS, Alonso A, Gottesman RF.. Neurology. 2013;81(15):1308-1313.

Intraindividual variability in domain-specific cognition and risk of mild cognitive impairment and dementia. Vaughan L, Leng I, Dagenbach D, Resnick SM, Rapp SR, Jennings JM, Brunner RL, Simpson SL, Beavers DP, Coker LH, Gaussoin SA, Sink KM, Espeland MA.. Curr Gerontol Geriatr Res. 2013;():495793.

Educational attainment, MRI changes, and cognitive function in older postmenopausal women from the Women's Health Initiative Memory Study. Rapp SR, Espeland MA, Manson JE, Resnick SM, Bryan NR, Smoller S, Coker LH, Phillips LS, Stefanick ML, Sarto GE.. Int J Psychiatry Med. 2013;46(2):121-143.

Common variants at 12q14 and 12q24 are associated with hippocampal volume. Bis JC, DeCarli C, Smith AV, van der Lijn F, Crivello F, Fornage M, Debette S, Shulman JM, Schmidt H, Srikanth V, Schuur M, Yu L, Choi SH, Sigurdsson S, Verhaaren BF, DeStefano AL, Lambert JC, Jack CR Jr, Struchalin M,.. Nat Genet. 2012;44(5):545-551.

Common variants at 6q22 and 17q21 are associated with intracranial volume. Ikram MA, Fornage M, Smith AV, Seshadri S, Schmidt R, Debette S, Vrooman HA, Sigurdsson S, Ropele S, Taal HR, Mook-Kanamori DO, Coker LH, Longstreth WT Jr, Niessen WJ, DeStefano AL, Beiser A, Zijdenbos AP, Struchalin M, Jack CR Jr,.. Nat Genet. 2012;44(5):539-544.

Validation of a cognitive assessment battery administered over the telephone. Rapp SR, Legault C, Espeland MA, Resnick SM, Hogan PE, Coker LH, Dailey M, Shumaker SA.. J Am Geriatr Soc. 2012;60(9):1616-1623.

Interaction between body mass index and central adiposity and risk of incident cognitive impairment and dementia: results from the Women's Health Initiative Memory Study. Kerwin DR, Gaussoin SA, Chlebowski RT, Kuller LH, Vitolins M, Coker LH, Kotchen JM, Nicklas BJ, Wassertheil-Smoller S, Espeland MA, et al.. J Am Geriatr Soc. 2011;59(1):107-112.

Vascular risk factors and longitudinal changes on brain MRI: the ARIC study. Knopman DS, Penman AD, Catellier DJ, Coker LH, Shibata DK, Sharrett AR, Mosley TH Jr.. Neurology. 2011;76(22):1879-1885.

Depressive symptoms, brain volumes and subclinical cerebrovascular disease in postmenopausal women: the Women's Health Initiative MRI Study. Goveas JS, Espeland MA, Hogan P, Dotson V, Tarima S, Coker LH, Ockene J, Brunner R, Woods NF, Wassertheil-Smoller S, et al.. J Affect Disord. 2011;132(1-2):275-284.

Advanced glycation end products, diabetes, and the brain [editorial]. Coker LH, Wagenknecht LE.. Neurology. 2011;77(14):1326-1327.

Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy. Launer LJ, Miller ME, Williamson JD, Lazar RM, Gerstein H, Ding J, Lovato LC, Lovato J, Coker L, Maldjian J, et al.. Lancet Neurol. 2011;10(11):969-977.

Brain MRI predictors of global and domain specific cognitive function at 10 years follow up: ARIC brain MRI study [abstract]. Coker L, Knopman D, Catellier D, Shibata D, Burdette J, Mosley T.. Alzheimers Dement. 2011;7(4 Suppl):S733.

Domain-specific cognitive function and fine motor speed in women 65 years and older with type 2 diabetes mellitus: results from the Women's Health Initiative Study of Cognitive Aging [abstract]. Espeland MA, Miller ME, Goveas JS, Hogan PE, Coker LH, Williamson J, Naughton M, Resnick SM.. Diabetes. 2011;60(Suppl 1):A69-A70.

What have we learned from the Women's Health Initiative about racial/ethnic minority women's health? [abstract]. Cochrane BB, Benavente VG, Coker LH.. Gerontologist. 2011;51(Suppl 2):106.

Affect, depression, and cognition in Cognition in the Study of Tamoxifen and Raloxifene (CO-STAR) [abstract]. Danhauer SC, Legault C, Costantino JP, Avis NE, Rapp S, Coker LH, Terracciano A, Shumaker SA.. Gerontologist. 2011;51(Suppl 2):292.

Blood pressure and white-matter disease progression in a biethnic cohort: Atherosclerosis Risk in Communities (ARIC) Study. Gottesman RF, Coresh J, Catellier DJ, Sharrett AR, Rose KM, Coker LH, Shibata DK, Knopman DS, Jack CR, Mosley TH Jr.. Stroke. 2010;41(1):3-8.

Postmenopausal hormone therapy and cognitive outcomes: the Women's Health Initiative Memory Study (WHIMS). Coker LH, Espeland MA, Rapp SR, Legault C, Resnick SM, Hogan P, Gaussoin S, Dailey M, Shumaker SA.. J Steroid Biochem Mol Biol. 2010;118(4-5):304-310.

Relative effects of tamoxifen, raloxifene, and conjugated equine estrogens on cognition. Espeland MA, Shumaker SA, Limacher M, Rapp SR, Bevers TB, Barad DH, Coker LH, Gaussoin SA, Stefanick ML, Lane DS, et al.. J Womens Health. 2010;19(3):371-379.

Retinal microvascular signs and 10-year risk of cerebral atrophy: the Atherosclerosis Risk in Communities (ARIC) study. Kawasaki R, Cheung N, Mosley T, Islam AFM, Sharrett AR, Klein R, Coker LH, Knopman DS, Shibata DK, Catellier D, et al.. Stroke. 2010;41(8):1826-1828.

Long-term effects of conjugated equine estrogen therapies on domain-specific cognitive function: results from the Women's Health Initiative study of cognitive aging extension. Espeland MA, Brunner RL, Hogan PE, Rapp SR, Coker LH, Legault C, Granek I, Resnick SM.. J Am Geriatr Soc. 2010;58(7):1263-1271.

Retinal microvascular abnormalities and subclinical magnetic resonance imaging brain infarct: a prospective study. Cheung N, Mosley T, Islam A, Kawasaki R, Sharrett AR, Klein R, Coker LH, Knopman DS, Shibata DK, Catellier D, et al.. Brain. 2010;133(Pt 7):1987-1993.

The cross-sectional relationship between body mass index, waist-hip ratio, and cognitive performance in postmenopausal women enrolled in the Women's Health Initiative. Kerwin DR, Zhang Y, Kotchen JM, Espeland MA, Van Horn L, McTigue KM, Robinson JG, Powell L, Kooperberg C, Coker LH, et al.. J Am Geriatr Soc. 2010;58(8):1427-1432.

Educational attainment, MRI changes and cognitive function in postmenopausal women [abstract]. Rapp S, Espeland MA, Manson JE, Resnick S, Bryan NR, Coker LH, Phillips L, Stefanick ML.. Gerontologist. 2010;50(Suppl 1):308.

Longitudinal imaging changes and vascular risk factors: a 10-year study [abstract]. Knopman DS, Penman AD, Coker LH, Catellier DJ, Shibata D, Mosley TH.. Alzheimers Dement. 2010;6(4 Suppl):S21.

Postmenopausal hormone therapy and subclinical cerebrovascular disease: the WHIMS-MRI Study. Coker LH, Hogan PE, Bryan NR, Kuller LH, Margolis KL, Bettermann K, Wallace RB, Lao Z, Freeman R, Shumaker SA, et al.. Neurology. 2009;72(2):125-134.

Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors: the Action to Control Cardiovascular Risk in Diabetes-Memory in Diabetes (ACCORD-MIND) trial. Cukierman-Yaffe T, Gerstein HC, Williamson JD, Lazar RM, Lovato L, Miller ME, Coker LH, Murray A, Sullivan MD, Marcovina SM, et al.. Diabetes Care. 2009;32(2):221-226.

Fourteen-year longitudinal study of vascular risk factors, APOE genotype, and cognition: the ARIC MRI Study. Knopman DS, Mosley TH, Catellier DJ, Coker LH.. Alzheimers Dement. 2009;5(3):207-214.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Social Sciences & Health Policy

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