Laura H. Coker, Ph.D.Wake Forest School of Medicine

Laura H. Coker, Ph.D.

Associate Professor,

Contact Information

Academic: 336-716-3324 | Department: 336-716-3324


Education & Training

  • B.S.N., University of North Carolina-Greensboro, 1985
  • M.S.N., University of North Carolina-Greensboro, 1990
  • Ph.D., University of North Carolina-Greensboro, 1998


  • American Academy of Neurology
  • American Nurses Association
  • Gerontological Society Of Amer
  • Soc Clin Trials
Laura H. Coker, Ph.D.

Laura H. Coker, Ph.D.

Associate Professor, Social Sciences & Health Policy
Office of Women in Medicine and Science
Sticht Center on Aging

Research Interests

aging, cognition/learning, communication/speech/hearing, drugs/therapeutic agents pharm, hypertension, radiology imaging/nuclear medi, rehabilitation

Contact Information

Academic: 336-716-3324 | Department: 336-716-3324


Recent Publications

Ibrahim-Verbaas CA, Bressler J, Debette S, Schuur M, Smith AV, Bis JC, Davies G, Trompet S, Smith JA, Wolf C, Chibnik LB, Liu Y, Vitart V, Kirin M, Petrovic K, Polasek O, Zgaga L, Fawns-Ritchie C, Hoffmann P, Karjalainen J, Lahti J, Llewellyn DJ,. GWAS for executive function and processing speed suggests involvement of the CADM2 gene. Mol Psychiatry. 2016;21(2):189-197.

Haring B, Wu C, Coker LH, Seth A, Snetselaar L, Manson JE, Rossouw JE, Wassertheil-Smoller S. Hypertension, dietary sodium, and cognitive decline: results from the Women's Health Initiative Memory Study. Am J Hypertens. 2016;29(2):202-216.

Cene CW, Dilworth-Anderson P, Leng I, Garcia L, Benavente V, Rosal M, Vaughan L, Coker LH, Corbie-Smith G, Kim M, Bell CL, Robinson JG, Manson JE, Cochrane B. Correlates of successful aging in racial and ethnic minority women age 80 years and older: findings from the Women's Health Initiative. J Gerontol A Biol Sci Med Sci. 2016;71(Suppl 1):S87-99.

Knopman DS, Gottesman RF, Sharrett AR, Wruck LM, Windham BG, Coker L, Schneider AL, Hengrui S, Alonso A, Coresh J, Albert MS, Mosley TH Jr. Mild cognitive impairment and dementia prevalence: the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS). Alzheimers Dement (Amst). 2016;2():1-11.

Schneider AL, Sharrett AR, Gottesman RF, Coresh J, Coker L, Wruck L, Selnes OA, Deal J, Knopman D, Mosley TH. Normative data for 8 neuropsychological tests in older blacks and whites from the Atherosclerosis Risk in Communities (ARIC) study. Alzheimer Dis Assoc Disord. 2015;29(1):32-44.

Rosso AL, Lee BK, Stefanick ML, Kroenke CH, Coker LH, Woods NF, Michael YL. Caregiving frequency and physical function: the Women's Health Initiative. J Gerontol A Biol Sci Med Sci. 2015;70(2):210-215.

Knopman DS, Griswold ME, Lirette ST, Gottesman RF, Kantarci K, Sharrett AR, Jack CR Jr, Graff-Radford J, Schneider AL, Windham BG, Coker LH, Albert MS, Mosley TH Jr. Vascular imaging abnormalities and cognition: mediation by cortical volume in nondemented individuals: Atherosclerosis Risk in Communities-Neurocognitive Study. Stroke. 2015;46(2):433-440.

Debette S, Ibrahim Verbaas CA, Bressler J, Schuur M, Smith A, Bis JC, Davies G, Wolf C, Gudnason V, Chibnik LB, Yang Q, deStefano AL, de Quervain DJ, Srikanth V, Lahti J, Grabe HJ, Smith JA, Priebe L, Yu L, Karbalai N, Hayward C, Wilson JF, Campbell H,. Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. Biol Psychiatry. 2015;77(8):749-763.

Agnew-Blais JC, Wassertheil-Smoller S, Kang JH, Hogan PE, Coker LH, Snetselaar LG, Smoller JW. Folate, vitamin B-6, and vitamin B-12 intake and mild cognitive impairment and probable dementia in the Women's Health Initiative Memory Study. J Acad Nutr Diet. 2015;115(2):231-241.

Dearborn JL, Schneider AL, Sharrett AR, Mosley TH, Bezerra DC, Knopman DS, Selvin E, Jack CR, Coker LH, Alonso A, Wagenknecht LE, Windham BG, Gottesman RF. Obesity, insulin resistance, and incident small vessel disease on magnetic resonance imaging: Atherosclerosis Risk in Communities study. Stroke. 2015;46(11):3131-3136.

Williamson JD, Launer LJ, Bryan RN, Coker LH, Lazar RM, Gerstein HC, Murray AM, Sullivan MD, Horowitz KR, Ding J, Marcovina S, Lovato L, Lovato J, Margolis KL, Davatzikos C, Barzilay J, Ginsberg HN, Linz PE, Miller ME. Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels: a randomized clinical trial. JAMA Intern Med. 2014;174(3):324-333.

Coker LH, Espeland MA, Hogan PE, Resnick SM, Bryan RN, Robinson JG, Goveas JS, Davatzikos C, Kuller LH, Williamson JD, Bushnell CD, Shumaker SA. Change in brain and lesion volumes after CEE therapies: the WHIMS-MRI studies. Neurology. 2014;82(5):427-434.

Sink KM, Chelune G, Coker L, Gaussoin S, Lerner A, Nichols L, Pajewski NM, Rapp S, Wadley V, Williamson J. The Montreal Cognitive Assessment (MoCA) in 8,724 SPRINT participants [abstract]. J Am Geriatr Soc. 2014;62(Suppl 1):S9-S10.

Gottesman RF, Rawlings AM, Sharrett AR, Albert M, Alonso A, Bandeen-Roche K, Coker LH, Coresh J, Couper DJ, Griswold ME, Heiss G, Knopman DS, Patel MD, Penman AD, Power MC, Selnes OA, Schneider AL, Wagenknecht LE, Windham BG, Wruck LM, Mosley TH. Impact of differential attrition on the association of education with cognitive change over 20 years of follow-up: the ARIC Neurocognitive Study. Am J Epidemiol. 2014;179(8):956-966.

Yaffe K, Vittinghoff E, Pletcher MJ, Hoang TD, Launer LJ, Whitmer R, Coker LH, Sidney S. Early adult to midlife cardiovascular risk factors and cognitive function. Circulation. 2014;129(15):1560-1567.

Michos ED, Carson KA, Schneider AL, Lutsey PL, Xing L, Sharrett AR, Alonso A, Coker LH, Gross M, Post W, Mosley TH, Gottesman RF. Vitamin D and subclinical cerebrovascular disease: the Atherosclerosis Risk in Communities Brain Magnetic Resonance Imaging study. JAMA Neurol. 2014;71(7):863-871.

Gottesman RF, Schneider AL, Albert M, Alonso A, Bandeen-Roche K, Coker L, Coresh J, Knopman D, Power MC, Rawlings A, Sharrett AR, Wruck LM, Mosley TH. Midlife hypertension and 20-year cognitive change: the Atherosclerosis Risk in Communities Neurocognitive Study. JAMA Neurol. 2014;71(10):1218-1227.

Dearborn JL, Knopman D, Sharrett AR, Schneider AL, Jack CR Jr, Coker LH, Alonso A, Selvin E, Mosley TH, Wagenknecht LE, Windham BG, Gottesman RF. The metabolic syndrome and cognitive decline in the Atherosclerosis Risk in Communities study (ARIC).. Dement Geriatr Cogn Disord. 2014;38(5-6):337-346.

Espeland MA, Bryan RN, Goveas JS, Robinson JG, Siddiqui MS, Liu S, Hogan PE, Casanova R, Coker LH, Yaffe K, Masaki K, Rossom R, Resnick SM. Influence of type 2 diabetes on brain volumes and changes in brain volumes: results from the Women's Health Initiative magnetic resonance imaging studies. Diabetes Care. 2013;36(1):90-97.

Graff-Radford NR, Knopman DS, Penman AD, Coker LH, Mosley TH. Do systolic BP and pulse pressure relate to ventricular enlargement?. Eur J Neurol. 2013;20(4):720-724.

Hek K, Demirkan A, Lahti J, Terracciano A, Teumer A, Cornelis MC, Amin N, Bakshis E, Baumert J, Ding J, Liu Y, Marciante K, Meirelles O, Nalls MA, Sun YV, Vogelzangs N, Yu L, Bandinelli S, Benjamin EJ, Bennett DA, Boomsma D,. A genome-wide association study of depressive symptoms. Biol Psychiatry. 2013;73(7):667-678.

Danhauer SC, Legault C, Bandos H, Kidwell K, Costantino J, Vaughan L, Avis NE, Rapp S, Coker LH, Naughton M, Naylor C, Terracciano A, Shumaker S. Positive and negative affect, depression, and cognitive processes in the Cognition in the Study of Tamoxifen and Raloxifene (Co-STAR) Trial. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2013;20(5):532-552.

Hamedani AG, Rose KM, Peterlin BL, Mosley TH, Coker LH, Jack CR, Knopman DS, Alonso A, Gottesman RF. Migraine and white matter hyperintensities: the ARIC MRI study. Neurology. 2013;81(15):1308-1313.

Vaughan L, Leng I, Dagenbach D, Resnick SM, Rapp SR, Jennings JM, Brunner RL, Simpson SL, Beavers DP, Coker LH, Gaussoin SA, Sink KM, Espeland MA. Intraindividual variability in domain-specific cognition and risk of mild cognitive impairment and dementia. Curr Gerontol Geriatr Res. 2013;():495793.

Rapp SR, Espeland MA, Manson JE, Resnick SM, Bryan NR, Smoller S, Coker LH, Phillips LS, Stefanick ML, Sarto GE. Educational attainment, MRI changes, and cognitive function in older postmenopausal women from the Women's Health Initiative Memory Study. Int J Psychiatry Med. 2013;46(2):121-143.

Bis JC, DeCarli C, Smith AV, van der Lijn F, Crivello F, Fornage M, Debette S, Shulman JM, Schmidt H, Srikanth V, Schuur M, Yu L, Choi SH, Sigurdsson S, Verhaaren BF, DeStefano AL, Lambert JC, Jack CR Jr, Struchalin M,. Common variants at 12q14 and 12q24 are associated with hippocampal volume. Nat Genet. 2012;44(5):545-551.

Ikram MA, Fornage M, Smith AV, Seshadri S, Schmidt R, Debette S, Vrooman HA, Sigurdsson S, Ropele S, Taal HR, Mook-Kanamori DO, Coker LH, Longstreth WT Jr, Niessen WJ, DeStefano AL, Beiser A, Zijdenbos AP, Struchalin M, Jack CR Jr,. Common variants at 6q22 and 17q21 are associated with intracranial volume. Nat Genet. 2012;44(5):539-544.

Rapp SR, Legault C, Espeland MA, Resnick SM, Hogan PE, Coker LH, Dailey M, Shumaker SA. Validation of a cognitive assessment battery administered over the telephone. J Am Geriatr Soc. 2012;60(9):1616-1623.

Kerwin DR, Gaussoin SA, Chlebowski RT, Kuller LH, Vitolins M, Coker LH, Kotchen JM, Nicklas BJ, Wassertheil-Smoller S, Espeland MA, et al. Interaction between body mass index and central adiposity and risk of incident cognitive impairment and dementia: results from the Women's Health Initiative Memory Study. J Am Geriatr Soc. 2011;59(1):107-112.

Knopman DS, Penman AD, Catellier DJ, Coker LH, Shibata DK, Sharrett AR, Mosley TH Jr. Vascular risk factors and longitudinal changes on brain MRI: the ARIC study. Neurology. 2011;76(22):1879-1885.

Goveas JS, Espeland MA, Hogan P, Dotson V, Tarima S, Coker LH, Ockene J, Brunner R, Woods NF, Wassertheil-Smoller S, et al. Depressive symptoms, brain volumes and subclinical cerebrovascular disease in postmenopausal women: the Women's Health Initiative MRI Study. J Affect Disord. 2011;132(1-2):275-284.

Coker LH, Wagenknecht LE. Advanced glycation end products, diabetes, and the brain [editorial]. Neurology. 2011;77(14):1326-1327.

Launer LJ, Miller ME, Williamson JD, Lazar RM, Gerstein H, Ding J, Lovato LC, Lovato J, Coker L, Maldjian J, et al. Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy. Lancet Neurol. 2011;10(11):969-977.

Coker L, Knopman D, Catellier D, Shibata D, Burdette J, Mosley T. Brain MRI predictors of global and domain specific cognitive function at 10 years follow up: ARIC brain MRI study [abstract]. Alzheimers Dement. 2011;7(4 Suppl):S733.

Espeland MA, Miller ME, Goveas JS, Hogan PE, Coker LH, Williamson J, Naughton M, Resnick SM. Domain-specific cognitive function and fine motor speed in women 65 years and older with type 2 diabetes mellitus: results from the Women's Health Initiative Study of Cognitive Aging [abstract]. Diabetes. 2011;60(Suppl 1):A69-A70.

Cochrane BB, Benavente VG, Coker LH. What have we learned from the Women's Health Initiative about racial/ethnic minority women's health? [abstract]. Gerontologist. 2011;51(Suppl 2):106.

Danhauer SC, Legault C, Costantino JP, Avis NE, Rapp S, Coker LH, Terracciano A, Shumaker SA. Affect, depression, and cognition in Cognition in the Study of Tamoxifen and Raloxifene (CO-STAR) [abstract]. Gerontologist. 2011;51(Suppl 2):292.

Gottesman RF, Coresh J, Catellier DJ, Sharrett AR, Rose KM, Coker LH, Shibata DK, Knopman DS, Jack CR, Mosley TH Jr. Blood pressure and white-matter disease progression in a biethnic cohort: Atherosclerosis Risk in Communities (ARIC) Study. Stroke. 2010;41(1):3-8.

Coker LH, Espeland MA, Rapp SR, Legault C, Resnick SM, Hogan P, Gaussoin S, Dailey M, Shumaker SA. Postmenopausal hormone therapy and cognitive outcomes: the Women's Health Initiative Memory Study (WHIMS). J Steroid Biochem Mol Biol. 2010;118(4-5):304-310.

Espeland MA, Shumaker SA, Limacher M, Rapp SR, Bevers TB, Barad DH, Coker LH, Gaussoin SA, Stefanick ML, Lane DS, et al. Relative effects of tamoxifen, raloxifene, and conjugated equine estrogens on cognition. J Womens Health. 2010;19(3):371-379.

Kawasaki R, Cheung N, Mosley T, Islam AFM, Sharrett AR, Klein R, Coker LH, Knopman DS, Shibata DK, Catellier D, et al. Retinal microvascular signs and 10-year risk of cerebral atrophy: the Atherosclerosis Risk in Communities (ARIC) study. Stroke. 2010;41(8):1826-1828.

Espeland MA, Brunner RL, Hogan PE, Rapp SR, Coker LH, Legault C, Granek I, Resnick SM. Long-term effects of conjugated equine estrogen therapies on domain-specific cognitive function: results from the Women's Health Initiative study of cognitive aging extension. J Am Geriatr Soc. 2010;58(7):1263-1271.

Cheung N, Mosley T, Islam A, Kawasaki R, Sharrett AR, Klein R, Coker LH, Knopman DS, Shibata DK, Catellier D, et al. Retinal microvascular abnormalities and subclinical magnetic resonance imaging brain infarct: a prospective study. Brain. 2010;133(Pt 7):1987-1993.

Kerwin DR, Zhang Y, Kotchen JM, Espeland MA, Van Horn L, McTigue KM, Robinson JG, Powell L, Kooperberg C, Coker LH, et al. The cross-sectional relationship between body mass index, waist-hip ratio, and cognitive performance in postmenopausal women enrolled in the Women's Health Initiative. J Am Geriatr Soc. 2010;58(8):1427-1432.

Rapp S, Espeland MA, Manson JE, Resnick S, Bryan NR, Coker LH, Phillips L, Stefanick ML. Educational attainment, MRI changes and cognitive function in postmenopausal women [abstract]. Gerontologist. 2010;50(Suppl 1):308.

Knopman DS, Penman AD, Coker LH, Catellier DJ, Shibata D, Mosley TH. Longitudinal imaging changes and vascular risk factors: a 10-year study [abstract]. Alzheimers Dement. 2010;6(4 Suppl):S21.

Coker LH, Hogan PE, Bryan NR, Kuller LH, Margolis KL, Bettermann K, Wallace RB, Lao Z, Freeman R, Shumaker SA, et al. Postmenopausal hormone therapy and subclinical cerebrovascular disease: the WHIMS-MRI Study. Neurology. 2009;72(2):125-134.

Cukierman-Yaffe T, Gerstein HC, Williamson JD, Lazar RM, Lovato L, Miller ME, Coker LH, Murray A, Sullivan MD, Marcovina SM, et al. Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors: the Action to Control Cardiovascular Risk in Diabetes-Memory in Diabetes (ACCORD-MIND) trial. Diabetes Care. 2009;32(2):221-226.

Knopman DS, Mosley TH, Catellier DJ, Coker LH. Fourteen-year longitudinal study of vascular risk factors, APOE genotype, and cognition: the ARIC MRI Study. Alzheimers Dement. 2009;5(3):207-214.

Coker LH. Aging, cognition, and diabetes: the transition from self-care to a caregiver for diabetes self-management In: Shumaker SA, Ockene JK, Reikert KA, eds. The handbook of health behavior change. 3rd ed. New York: Springer;2009: 627-642.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Social Sciences & Health Policy

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