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Ralph B. D'Agostino Jr, Ph.D.Wake Forest School of Medicine

Ralph B. D'Agostino Jr, Ph.D.

Core Director,
Professor,

Office of Research

Clinical Interests

Lung Cancer, Cancer Prevention, Epidemiology, Head and Neck Cancers, Pediatric Trauma, Cancer Symptom Management, Prostate Cancer, Diabetes, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus in Adolescents, Breast Cancer

Contact Information

Academic: 336-716-9410 | Department: 336-716-2011

Email: rdagosti@wakehealth.edu

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Education & Training

  • A.B., Bowdoin College, 1988
  • A.M., Harvard University, 1989
  • Ph.D., Harvard University, 1994
Ralph B. D'Agostino Jr, Ph.D.

Ralph B. D'Agostino Jr, Ph.D.

Core Director, Comprehensive Cancer Center
Professor, Biostatistical Sciences
Institute for Regenerative Medicine
Office of Research

Research Interests

Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Insulin Resistance; Anthracyclines; Head and Neck Neoplasms
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Contact Information

Academic: 336-716-9410 | Department: 336-716-2011

Email: rdagosti@wakehealth.edu

Related Links

Recent Publications

The impact of hospice services in the care of patients with advanced stage nonsmall cell lung cancer. Duggan KT, Duffus SH, D'Agostino RB Jr, Petty WJ, Streer NP, Stephenson RC.. J Palliat Med. 2017;20(1):29-34.

Pepsin in saliva as a biomarker for oropharyngeal reflux compared with 24-hour esophageal impedance/pH monitoring in pediatric patients. Fortunato JE, D'Agostino RB Jr, Lively MO.. Neurogastroenterol Motil. 2017;29(2):e12936.

Association between use of a scalp cooling device and alopecia after chemotherapy for breast cancer. Rugo HS, Klein P, Melin SA, Hurvitz SA, Melisko ME, Moore A, Park G, Mitchel J, Bageman E, D'Agostino RB Jr, Ver Hoeve ES, Esserman L, Cigler T.. JAMA. 2017;317(6):606-614.

Predictors of dyslipidemia over time in youth with type 1 diabetes: for the SEARCH for Diabetes in Youth study. Shah AS, Maahs DM, Stafford JM, Dolan LM, Lang W, Imperatore G, Bell RA, Liese AD, Reynolds K, Pihoker C, Marcovina S, D'Agostino RB Jr, Dabelea D.. Diabetes Care. 2017;40(4):607-613.

Association of type 1 diabetes vs type 2 diabetes diagnosed during childhood and adolescence with complications during teenage years and young adulthood. Dabelea D, Stafford JM, Mayer-Davis EJ, D'Agostino R Jr, Dolan L, Imperatore G, Linder B, Lawrence JM, Marcovina SM, Mottl AK, Black MH, Pop-Busui R, Saydah S, Hamman RF, Pihoker C.. JAMA. 2017;317(8):825-835.

Predicting mortality and independence at discharge in the aging traumatic brain injury population using data available at admission. Miller PR, Chang MC, Hoth JJ, Hildreth AN, Wolfe SQ, Gross JL, Martin RS, Carter JE, Meredith JW, D'Agostino R Jr.. J Am Coll Surg. 2017;224(4):680-685.

Frequency of transition from stage A to B or C heart failure after potentially cardiotoxic chemotherapy [abstract]. Jones D, Suerken C, D'Agostino R, Melendez G, Jordan J, Hundley W.. J Am Coll Cardiol. 2017;69(11 Suppl):924.

Decreases in left ventricular mass and not left ventricular ejection fraction are associated with heart failure symptoms in cancer patients six months after potentially cardiotoxic chemotherapy [abstract]. Jordan JH, Melendez G, Suerken C, D'Agostino R, Hundley W.. J Am Coll Cardiol. 2017;69(11 Suppl):1410.

Frequency of left ventricular end-diastolic volume-mediated declines in ejection fraction in patients receiving potentially cardiotoxic cancer treatment. Melendez GC, Sukpraphrute B, D'Agostino RB Jr, Jordan JH, Klepin HD, Ellis L, Lamar Z, Vasu S, Lesser G, Burke GL, Weaver KE, Ntim WO, Hundley WG.. Am J Cardiol. 2017;119(10):1637-1642.

Research pearls: the significance of statistics and perils of pooling. Part 2: predictive modeling. Hohmann E, Wetzler MJ, D'Agostino RB Jr.. Arthroscopy. 2017;33(7):1423-1432.

Safety and tolerability of the first-in-class agent CPI-613 in combination with modified FOLFIRINOX in patients with metastatic pancreatic cancer: a single-centre, open-label, dose-escalation, phase 1 trial. Alistar A, Morris BB, Desnoyer R, Klepin HD, Hosseinzadeh K, Clark C, Cameron A, Leyendecker J, D'Agostino R Jr, Topaloglu U, Boteju LW, Boteju AR, Shorr R, Zachar Z, Bingham PM, Ahmed T, Crane S, Shah R, Migliano JJ, Pardee TS, Miller L,.. Lancet Oncol. 2017;18(6):770-778.

Circulating mutational portrait of cancer: manifestation of aggressive clonal events in both early and late stages. Yang M, Topaloglu U, Petty WJ, Pagni M, Foley KL, Grant SC, Robinson M, Bitting RL, Thomas A, Alistar AT, Desnoyers RJ, Goodman M, Albright C, Porosnicu M, Vatca M, Qasem SA, DeYoung B, Kytola V, Nykter M, Chen K, Levine EA, Staren ED,.. J Hematol Oncol. 2017;10(1):100.

Progressive 3-month increase in LV myocardial ECV after anthracycline-based chemotherapy [letter]. Melendez GC, Jordan JH, D'Agostino RB Jr, Vasu S, Hamilton CA, Hundley WG.. JACC Cardiovasc Imaging. 2017;10(6):708-709.

Urinary F2-isoprostanes and the risk of hypertension. Melton CD, Luo R, Wong BJ, Spasojevic I, Wagenknecht LE, D'Agostino RB Jr, Il'yasova D.. Ann Epidemiol. 2017;27(6):391-396.

Early myocardial strain changes during potentially cardiotoxic chemotherapy may occur as a result of reductions in left ventricular end-diastolic volume: the need to interpret left ventricular strain with volumes [research letter]. Jordan JH, Sukpraphrute B, Melendez GC, Jolly MP, D'Agostino RB Jr, Hundley WG.. Circulation. 2017;135(25):2575-2577.

Vitamin D and albuminuria in youth with and without type 1 diabetes. Nandi-Munshi D, Afkarian M, Whitlock KB, Crandell JL, Bell RA, D'Agostino R, Saydah S, Mottl AK, Dabelea D, Black MH, Mayer-Davis EJ, Pihoker C.. Hormone Res Paediatr. 2017;87(6):385-395.

Serum cystatin C in youth with diabetes: The SEARCH for Diabetes in Youth Study. Kanakatti Shankar R, Dolan LM, Isom S, Saydah S, Maahs DM, Dabelea D, Reynolds K, Hirsch IB, Rodriguez BL, Mayer-Davis EJ, Marcovina S, D'Agostino R Jr, Mauer M, Mottl AK.. Diabetes Res Clin Pract. 2017;130():258-265.

Complications of diabetes diagnosed in children and adolescents [reply to letter]. Dabelea D, D'Agostino R Jr, Mayer-Davis EJ.. JAMA. 2017;317(24):2553-2554.

The Comprehensive Post-Acute Stroke Services (COMPASS) study: design and methods for a cluster-randomized pragmatic trial. Duncan PW, Bushnell CD, Rosamond WD, Jones Berkeley SB, Gesell SB, D'Agostino RB Jr, Ambrosius WT, Barton-Percival B, Bettger JP, Coleman SW, Cummings DM, Freburger JK, Halladay J, Johnson AM, Kucharska-Newton AM, Lundy-Lamm G,.. BMC Neurol. 2017;17(1):133.

Automated assessments of circumferential strain from cine CMR correlate with LVEF declines in cancer patients early after receipt of cardio-toxic chemotherapy. Jolly MP, Jordan JH, Melendez GC, McNeal GR, D'Agostino RB Jr, Hundley WG.. J Cardiovasc Magn Reson. 2017;19(1):59.

Mutational landscapes of smoking-related cancers in Caucasians and African Americans: precision oncology perspectives at Wake Forest Baptist Comprehensive Cancer Center. Kytola V, Topaloglu U, Miller LD, Bitting RL, Goodman MM, D Agostino RB Jr, Desnoyers RJ, Albright C, Yacoub G, Qasem SA, DeYoung B, Thorsson V, Shmulevich I, Yang M, Shcherban A, Pagni M, Liu L, Nykter M, Chen K, Hawkins GA, Grant SC,.. Theranostics. 2017;7(11):2914-2923.

Adjuvanting an inactivated influenza vaccine with conjugated R848 improves the level of antibody present at 6 months in a nonhuman primate neonate model. Holbrook BC, D'Agostino RB Jr, Tyler Aycock S, Jorgensen MJ, Hadimani MB, Bruce King S, Alexander-Miller MA.. Vaccine. 2017;35(45):6137-6142.

Predictors of increased carotid intima media thickness in youth with type 1 diabetes: the SEARCH CVD Study. Shah AS, Dabelea D, Fino NF, Dolan LM, Wadwa RP, D'Agostino R Jr, Hamman R, Marcovina S, Daniels SR, Urbina EM.. Diabetes Care. 2016;39(3):418-425.

Prognostic molecular subtypes of low-grade cancer of the appendix. Levine EA, Votanopoulos KI, Qasem SA, Philip J, Cummins KA, Chou JW, Ruiz J, D'Agostino R, Shen P, Miller LD.. J Am Coll Surg. 2016;222(4):493-503.

Transcatheter aortic valve replacement versus surgical valve replacement in intermediate-risk patients: a propensity score analysis. Thourani VH, Kodali S, Makkar RR, Herrmann HC, Williams M, Babaliaros V, Smalling R, Lim S, Malaisrie SC, Kapadia S, Szeto WY, Greason KL, Kereiakes D, Ailawadi G, Whisenant BK, Devireddy C, Leipsic J, Hahn RT, Pibarot P, Weissman NJ, Jaber WA,.. Lancet. 2016;387(10034):2218-2225.

Prostate-specific membrane antigen-targeted liposomes specifically deliver the Zn(2+) chelator TPEN inducing oxidative stress in prostate cancer cells. Stuart CH, Singh R, Smith TL, D'Agostino R Jr, Caudell D, Balaji KC, Gmeiner WH.. Nanomedicine (Lond). 2016;11(10):1207-1222.

Gene expression signatures of effector immune cell abundance are significantly associated with recurrence risk in colon cancer [abstract]. Alistar AT, Chifman J, D'Agostino R Jr, Miller LD.. Cancer Immunol Res. 2016;4(1 Suppl):A011.

Retrospective analysis of cisplatin nephrotoxicity in patients with head and neck cancer receiving outpatient treatment with concurrent high-dose cisplatin and radiotherapy. Faig J, Haughton M, Taylor RC, D'Agostino RB Jr, Whelen MJ, Porosnicu Rodriguez KA, Bonomi M, Murea M, Porosnicu M.. Am J Clin Oncol. 2016;():.

A novel R848-conjugated inactivated influenza virus vaccine is efficacious and safe in a neonate nonhuman primate model. Holbrook BC, Kim JR, Blevins LK, Jorgensen MJ, Kock ND, D'Agostino RB Jr, Aycock ST, Hadimani MB, King SB, Parks GD, Alexander-Miller MA.. J Immunol. 2016;197(2):555-564.

The mitochondrial metabolism inhibitor CPI-613 in combination with mFOLFIRINOX for pancreatic adenocarcinoma [abstract]. Alistar AT, Desnoyer R, D'Agostino R.. J Clin Oncol. 2016;34(4 Suppl):264.

Simultaneous targeting of Eph receptors in glioblastoma. Ferluga S, Tome CM, Herpai DM, D'Agostino R, Debinski W.. Oncotarget. 2016;7(37):59860-76.

Anthracycline-associated T1 mapping characteristics are elevated independent of the presence of cardiovascular comorbidities in cancer survivors. Jordan JH, Vasu S, Morgan TM, D'Agostino RB Jr, Melendez GC, Hamilton CA, Arai AE, Liu S, Liu CY, Lima JA, Bluemke DA, Burke GL, Hundley WG.. Circ Cardiovasc Imaging. 2016;9(8):e004325.

Adjuvanting an inactivated influenza vaccine with flagellin improves the function and quantity of the long-term antibody response in a nonhuman primate neonate model. Holbrook BC, D'Agostino RB Jr, Parks GD, Alexander-Miller MA.. Vaccine. 2016;34(39):4712-4717.

A novel R848-conjugated inactivated influenza virus vaccine is safe and efficacious in a neonate nonhuman primate model [abstract]. Holbrook B, Kim J, Blevins L, Jorgensen M, Kock N, D'Agostino R Jr, Aycock ST, Hadimani M, King SB, Parks G, Alexander-Miller M.. Eur J Immunol. 2016;46(Suppl 1):31.

5-alpha reductase inhibitors and the risk of prostate cancer mortality in men treated for benign prostatic hyperplasia. Wallner LP, DiBello Jr, Li BH, Van Den Eeden SK, Weinmann S, Ritzwoller DP, Abell JE, D'Agostino R Jr, Loo RK, Aaronson DS, Richert-Boe K, Horwitz RI, Jacobsen SJ.. Mayo Clin Proc. 2016;91(12):1717-1726.

Comparing two waist-to-height ratio measurements with cardiometabolic risk factors among youth with diabetes. Liu LL, Kahn HS, Pettitt DJ, Fino NF, Morgan T, Maahs DM, Crimmins NA, Lamichhane AP, Liese AD, D'Agostino RB Jr, Bell RA.. Int J Child Health Nutr. 2016;5(3):87-94.

CPI-613 enhances FOLFIRINOX response rate in stage IV pancreatic cancer [abstract]. Alistar AT, Desnoyers R, D'Agostino RJ, Pasche B.. Ann Oncol. 2016;27(Suppl 6):675P.

Chronic statin administration may attenuate early anthracycline-associated declines in left ventricular ejection function. Chotenimitkhun R, D'Agostino R Jr, Lawrence JA, Hamilton CA, Jordan JH, Vasu S, Lash TL, Yeboah J, Herrington DM, Hundley WG.. Can J Cardiol. 2015;31(3):302-307.

Urinary F2-isoprostanes and metabolic markers of fat oxidation. Il'yasova D, Wagenknecht LE, Spasojevic I, Watkins S, Bowden D, Wang F, D'Agostino RB Jr.. Oxid Med Cell Longev. 2015;2015():729191.

Association of parental history of diabetes with cardiovascular disease risk factors in children with type 2 diabetes. Law JR, Stafford JM, D'Agostino RB Jr, Badaru A, Crume TL, Dabelea D, Dolan LM, Lawrence JM, Pettitt DJ, Mayer-Davis EJ.. J Diabetes Complications. 2015;29(4):534-539.

Insulin sensitivity and arterial stiffness in youth with type 1 diabetes: the SEARCH CVD study. Shah AS, Black S, Wadwa RP, Schmiege SJ, Fino NF, Talton JW, D'Agostino R Jr, Hamman RF, Urbina EM, Dolan LM, Daniels SR, Marcovina SM, Dabelea D.. J Diabetes Complications. 2015;29(4):512-516.

Lack of significant association between serum inflammatory cytokine profiles and the presence of colorectal adenoma. Henry CJ, Sedjo RL, Rozhok A, Salstrom J, Ahnen D, Levin TR, D'Agostino R Jr, Haffner S, DeGregori J, Byers T.. BMC Cancer. 2015;15():123.

Genome wide identification of new genes and pathways in patients with both autoimmune thyroiditis and type 1 diabetes. Tomer Y, Dolan LM, Kahaly G, Divers J, D'Agostino RB Jr, Imperatore G, Dabelea D, Marcovina S, Black MH, Pihoker C, Hasham A, Hammerstad SS, Greenberg DA, Lotay V, Zhang W, Monti MC, Matheis N.. J Autoimmun. 2015;60():32-39.

Inclusion of flagellin during vaccination against influenza enhances recall responses in nonhuman primate neonates. Kim JR, Holbrook BC, Hayward SL, Blevins LK, Jorgensen MJ, Kock ND, De Paris K, D'Agostino R Jr, Aycock ST, Mizel SB, Parks GD, Alexander-Miller MA.. J Virol. 2015;89(14):7291-7303.

Myocardial extracellular volume is elevated in cancer survivors treated with anthracycline-based chemotherapy compared to cancer-free peers and newly diagnosed and untreated cancer patients: a single-center observational study of the. Jordan JH, Vasu S, Morgan T, D'Agostino R, Melendez GC, Hall M, Hamilton C, Arai A, Liu S, Liu C-Y, Lima J, Bluemke D, Hundley W.. J Am Coll Cardiol. 2015;65(10 Suppl):A1081.

Trends and characteristics of self-reported case presentation of diabetes diagnosis among youth from 2002 to 2010: findings from the SEARCH for Diabetes in Youth Study [letter]. Saydah SH, Imperatore G, Henkin L, D'Agostino R Jr, Divers J, Mayer-Davis EJ, Dabelea D, Klingensmith G, Pihoker C, Lawrence JM.. Diabetes Care. 2015;38(6):e84-e85.

Change in adiposity minimally affects the lipid profile in youth with recent onset type 1 diabetes. Shah AS, Dolan LM, Dabelea D, Stafford JM, D'Agostino RB Jr, Mayer-Davis EJ, Marcovina S, Imperatore G, Wadwa RP, Daniels SR, Reynolds K, Hamman RF, Bowlby DA, Maahs DM, Wagenknecht LE.. Pediatr Diabetes. 2015;16(4):280-286.

Interferon beta and interferon alpha 2a differentially protect head and neck cancer cells from vesicular stomatitis virus-induced oncolysis. Westcott MM, Liu J, Rajani K, D'Agostino R Jr, Lyles DS, Porosnicu M.. J Virol. 2015;89(15):7944-7954.

Longitudinal association between television watching and computer use and risk markers in diabetes in the SEARCH for Diabetes in Youth Study. Li C, Beech B, Crume T, D'Agostino RB Jr, Dabelea D, Kaar JL, Liese AD, Mayer-Davis EJ, Pate R, Pettitt DJ, Taplin C, Rodriguez B, Merchant AT.. Pediatr Diabetes. 2015;16(5):382-391.

Arterial stiffness in adolescents and young adults with and without type 1 diabetes: the SEARCH CVD study. Shah AS, Wadwa RP, Dabelea D, Hamman RF, D'Agostino R Jr, Marcovina S, Daniels SR, Dolan LM, Fino NF, Urbina EM.. Pediatr Diabetes. 2015;16(5):367-374.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Biostatistical Sciences

Clinical Interests

Lung Cancer, Cancer Prevention, Epidemiology, Head and Neck Cancers, Pediatric Trauma, Cancer Symptom Management, Prostate Cancer, Diabetes, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus in Adolescents, Breast Cancer
Ralph B. D'Agostino Jr, Ph.D.

Ralph B. D'Agostino Jr, Ph.D.

Core Director, Comprehensive Cancer Center
Professor, Biostatistical Sciences
Institute for Regenerative Medicine
Office of Research

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