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Ralph B. D'Agostino Jr, Ph.D.Wake Forest School of Medicine

Ralph B. D'Agostino Jr, Ph.D.

Core Director,

Office of Research

Clinical Interests

Lung Cancer, Cancer Prevention, Epidemiology, Head and Neck Cancers, Pediatric Trauma, Cancer Symptom Management, Prostate Cancer, Diabetes, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus in Adolescents

Contact Information

Academic: 336-716-9410 | Department: 336-716-2011


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Education & Training

  • A.B., Bowdoin College, 1988
  • A.M., Harvard University, 1989
  • Ph.D., Harvard University, 1994
Ralph B. D'Agostino Jr, Ph.D.

Ralph B. D'Agostino Jr, Ph.D.

Core Director, Comprehensive Cancer Center
Professor, Biostatistical Sciences
Institute for Regenerative Medicine
Office of Research

Research Interests

Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Insulin Resistance; Humans; Anthracyclines
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Contact Information

Academic: 336-716-9410 | Department: 336-716-2011


Related Links

Recent Publications

Retrospective analysis of cisplatin nephrotoxicity in patients with head and neck cancer receiving outpatient treatment with concurrent high-dose cisplatin and radiotherapy. Faig J, Haughton M, Taylor RC, D'Agostino RB Jr, Whelen MJ, Porosnicu Rodriguez KA, Bonomi M, Murea M, Porosnicu M.. Am J Clin Oncol. 2018;41(5):432-440.

Potential for health care cost savings with preoperative gastrostomy tube placement in the head and neck cancer population. Mays AC, Bartels HG, Wistermayer PR, Rohlfing ML, Gentile CM, D'Agostino R Jr, Waltonen JD.. Head Neck. 2018;40(1):111-119.

Food insecurity is associated with high risk glycemic control and higher health care utilization among youth and young adults with type 1 diabetes. Mendoza JA, Haaland W, D'Agostino RB, Martini L, Pihoker C, Frongillo EA, Mayer-Davis EJ, Liu LL, Dabelea D, Lawrence JM, Liese AD.. Diabetes Res Clin Pract. 2018;138():128-137.

Transfer from paediatric to adult care for young adults with Type 2 diabetes: the SEARCH for Diabetes in Youth Study. Agarwal S, Raymond JK, Isom S, Lawrence JM, Klingensmith G, Pihoker C, Corathers S, Saydah S, D'Agostino RB Jr, Dabelea D.. Diabet Med. 2018;35(4):504-512.

Neighborhood characteristics, food deserts, rurality, and type 2 diabetes in youth: findings from a case-control study. Liese AD, Lamichhane AP, Garzia SCA, Puett RC, Porter DE, Dabelea D, D'Agostino RB Jr, Standiford D, Liu L.. Health Place. 2018;50():81-88.

The adjuvant Bordetella Colonization Factor A attenuates alum-induced Th2 responses and enhances Bordetella pertussis clearance from mouse lungs. Jennings-Gee J, Quataert S, Ganguly T, D'Agostino R Jr, Deora R, Dubey P.. Infect Immun. 2018;():.

The impact of hospice services in the care of patients with advanced stage nonsmall cell lung cancer. Duggan KT, Duffus SH, D'Agostino RB Jr, Petty WJ, Streer NP, Stephenson RC.. J Palliat Med. 2017;20(1):29-34.

Pepsin in saliva as a biomarker for oropharyngeal reflux compared with 24-hour esophageal impedance/pH monitoring in pediatric patients. Fortunato JE, D'Agostino RB Jr, Lively MO.. Neurogastroenterol Motil. 2017;29(2):e12936.

Association between use of a scalp cooling device and alopecia after chemotherapy for breast cancer. Rugo HS, Klein P, Melin SA, Hurvitz SA, Melisko ME, Moore A, Park G, Mitchel J, Bageman E, D'Agostino RB Jr, Ver Hoeve ES, Esserman L, Cigler T.. JAMA. 2017;317(6):606-614.

Predictors of dyslipidemia over time in youth with type 1 diabetes: for the SEARCH for Diabetes in Youth study. Shah AS, Maahs DM, Stafford JM, Dolan LM, Lang W, Imperatore G, Bell RA, Liese AD, Reynolds K, Pihoker C, Marcovina S, D'Agostino RB Jr, Dabelea D.. Diabetes Care. 2017;40(4):607-613.

Association of type 1 diabetes vs type 2 diabetes diagnosed during childhood and adolescence with complications during teenage years and young adulthood. Dabelea D, Stafford JM, Mayer-Davis EJ, D'Agostino R Jr, Dolan L, Imperatore G, Linder B, Lawrence JM, Marcovina SM, Mottl AK, Black MH, Pop-Busui R, Saydah S, Hamman RF, Pihoker C.. JAMA. 2017;317(8):825-835.

Predicting mortality and independence at discharge in the aging traumatic brain injury population using data available at admission. Miller PR, Chang MC, Hoth JJ, Hildreth AN, Wolfe SQ, Gross JL, Martin RS, Carter JE, Meredith JW, D'Agostino R Jr.. J Am Coll Surg. 2017;224(4):680-685.

Frequency of transition from stage A to B or C heart failure after potentially cardiotoxic chemotherapy [abstract]. Jones D, Suerken C, D'Agostino R, Melendez G, Jordan J, Hundley W.. J Am Coll Cardiol. 2017;69(11 Suppl):924.

Decreases in left ventricular mass and not left ventricular ejection fraction are associated with heart failure symptoms in cancer patients six months after potentially cardiotoxic chemotherapy [abstract]. Jordan JH, Melendez G, Suerken C, D'Agostino R, Hundley W.. J Am Coll Cardiol. 2017;69(11 Suppl):1410.

Frequency of left ventricular end-diastolic volume-mediated declines in ejection fraction in patients receiving potentially cardiotoxic cancer treatment. Melendez GC, Sukpraphrute B, D'Agostino RB Jr, Jordan JH, Klepin HD, Ellis L, Lamar Z, Vasu S, Lesser G, Burke GL, Weaver KE, Ntim WO, Hundley WG.. Am J Cardiol. 2017;119(10):1637-1642.

Research pearls: the significance of statistics and perils of pooling. Part 2: predictive modeling. Hohmann E, Wetzler MJ, D'Agostino RB Jr.. Arthroscopy. 2017;33(7):1423-1432.

Safety and tolerability of the first-in-class agent CPI-613 in combination with modified FOLFIRINOX in patients with metastatic pancreatic cancer: a single-centre, open-label, dose-escalation, phase 1 trial. Alistar A, Morris BB, Desnoyer R, Klepin HD, Hosseinzadeh K, Clark C, Cameron A, Leyendecker J, D'Agostino R Jr, Topaloglu U, Boteju LW, Boteju AR, Shorr R, Zachar Z, Bingham PM, Ahmed T, Crane S, Shah R, Migliano JJ, Pardee TS, Miller L,.. Lancet Oncol. 2017;18(6):770-778.

Circulating mutational portrait of cancer: manifestation of aggressive clonal events in both early and late stages. Yang M, Topaloglu U, Petty WJ, Pagni M, Foley KL, Grant SC, Robinson M, Bitting RL, Thomas A, Alistar AT, Desnoyers RJ, Goodman M, Albright C, Porosnicu M, Vatca M, Qasem SA, DeYoung B, Kytola V, Nykter M, Chen K, Levine EA, Staren ED,.. J Hematol Oncol. 2017;10(1):100.

Progressive 3-month increase in LV myocardial ECV after anthracycline-based chemotherapy [letter]. Melendez GC, Jordan JH, D'Agostino RB Jr, Vasu S, Hamilton CA, Hundley WG.. JACC Cardiovasc Imaging. 2017;10(6):708-709.

Urinary F2-isoprostanes and the risk of hypertension. Melton CD, Luo R, Wong BJ, Spasojevic I, Wagenknecht LE, D'Agostino RB Jr, Il'yasova D.. Ann Epidemiol. 2017;27(6):391-396.

Early myocardial strain changes during potentially cardiotoxic chemotherapy may occur as a result of reductions in left ventricular end-diastolic volume: the need to interpret left ventricular strain with volumes [research letter]. Jordan JH, Sukpraphrute B, Melendez GC, Jolly MP, D'Agostino RB Jr, Hundley WG.. Circulation. 2017;135(25):2575-2577.

Vitamin D and albuminuria in youth with and without type 1 diabetes. Nandi-Munshi D, Afkarian M, Whitlock KB, Crandell JL, Bell RA, D'Agostino R, Saydah S, Mottl AK, Dabelea D, Black MH, Mayer-Davis EJ, Pihoker C.. Hormone Res Paediatr. 2017;87(6):385-395.

Serum cystatin C in youth with diabetes: The SEARCH for Diabetes in Youth Study. Kanakatti Shankar R, Dolan LM, Isom S, Saydah S, Maahs DM, Dabelea D, Reynolds K, Hirsch IB, Rodriguez BL, Mayer-Davis EJ, Marcovina S, D'Agostino R Jr, Mauer M, Mottl AK.. Diabetes Res Clin Pract. 2017;130():258-265.

Complications of diabetes diagnosed in children and adolescents [reply to letter]. Dabelea D, D'Agostino R Jr, Mayer-Davis EJ.. JAMA. 2017;317(24):2553-2554.

The Comprehensive Post-Acute Stroke Services (COMPASS) study: design and methods for a cluster-randomized pragmatic trial. Duncan PW, Bushnell CD, Rosamond WD, Jones Berkeley SB, Gesell SB, D'Agostino RB Jr, Ambrosius WT, Barton-Percival B, Bettger JP, Coleman SW, Cummings DM, Freburger JK, Halladay J, Johnson AM, Kucharska-Newton AM, Lundy-Lamm G,.. BMC Neurol. 2017;17(1):133.

Automated assessments of circumferential strain from cine CMR correlate with LVEF declines in cancer patients early after receipt of cardio-toxic chemotherapy. Jolly MP, Jordan JH, Melendez GC, McNeal GR, D'Agostino RB Jr, Hundley WG.. J Cardiovasc Magn Reson. 2017;19(1):59.

Mutational landscapes of smoking-related cancers in Caucasians and African Americans: precision oncology perspectives at Wake Forest Baptist Comprehensive Cancer Center. Kytola V, Topaloglu U, Miller LD, Bitting RL, Goodman MM, D Agostino RB Jr, Desnoyers RJ, Albright C, Yacoub G, Qasem SA, DeYoung B, Thorsson V, Shmulevich I, Yang M, Shcherban A, Pagni M, Liu L, Nykter M, Chen K, Hawkins GA, Grant SC,.. Theranostics. 2017;7(11):2914-2923.

Adjuvanting an inactivated influenza vaccine with conjugated R848 improves the level of antibody present at 6 months in a nonhuman primate neonate model. Holbrook BC, D'Agostino RB Jr, Tyler Aycock S, Jorgensen MJ, Hadimani MB, Bruce King S, Alexander-Miller MA.. Vaccine. 2017;35(45):6137-6142.

The paperless paradigm: transitioning to direct participant data entry in the search for diabetes in youth study [abstract]. Robertson J, Henkin L, Wilson K, Barnes J, Hepler J, Pihoker C, Loots B, Mottle AK, Wagenknecht L, D'Agostino R.. Trials. 2017;18(Suppl 1):P274.

Trends in glycemic medications and control in youths with type 2 diabetes (T2D): the search for Diabetes in Youth Study [abstract]. Shankar RR, Pinto CA, Wang TT, Stafford JM, D'Agostino RB, Lawrence JM, Kim G, Pihoker C, Dabelea D.. Hormone Res Paediatr. 2017;88(Suppl 1):16-17.

New promising combination therapy of a mitochondrial metabolism inhibitor with mFOLFIRINOX in pancreatic cancer [abstract]. Alistar AT, Pasche B, D'Agostino R, Pardee T, Luther S, Desnoyer R.. Ann Oncol. 2017;28(Suppl 5):1733PD.

The effect of metformin and statin medications on subclinical cardiovascular outcomes in youth with type 1 diabetes: the Search for Diabetes in Youth Study [abstract]. Gourgari E, Stafford J, Agostino RD [sic] [D'Agostino RB], Dolan LM, Lawrence JM, Mottl A, Pihoker C, Wadwa P, Dabelea D.. Hormone Res Paediatr. 2017;88(Suppl 1):228-229.

DBF 2.0: A web-based predictive model for distant brain failure, brain metastasis velocity, and early death after radiosurgery for brain metastases [abstract]. Henson A, Ayala-Peacock DN, Chung C, Hepel JT, Chao ST, Contessa JN, Fiveash JB, Attia A, McTyre E, Braunstein SE, Page BR, Shen C, Kleinberg LR, Watabe K, Pasche B, D'Agostino R Jr, Chan MD.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):E78-E79.

Results of a phase 2 study of consolidative thoracic radiotherapy and/or stereotactic body radiotherapy for oligometastatic NSCLC [abstract]. Hughes RT, Ahmed T, Urbanic JJ, D'Agostino R, Dothard A, Lally BE, Ruiz J, Hinson W, Bonomi M, Rusthoven KE, Petty WJ, Blackstock AW.. Int J Radiat Oncol Biol Phys. 2017;99(2 Suppl):S212.

Statistical comparison of the DANCE trial 12-month outcomes of adventitial dexamethasone versus comparator drug-coated balloon studies [abstract]. Razavi M, Jaff M, Donohoe D, D'Agostino R Jr, Adams G.. J Am Coll Cardiol. 2017;70(18 Suppl):B89.

Predictors of increased carotid intima media thickness in youth with type 1 diabetes: the SEARCH CVD Study. Shah AS, Dabelea D, Fino NF, Dolan LM, Wadwa RP, D'Agostino R Jr, Hamman R, Marcovina S, Daniels SR, Urbina EM.. Diabetes Care. 2016;39(3):418-425.

Prognostic molecular subtypes of low-grade cancer of the appendix. Levine EA, Votanopoulos KI, Qasem SA, Philip J, Cummins KA, Chou JW, Ruiz J, D'Agostino R, Shen P, Miller LD.. J Am Coll Surg. 2016;222(4):493-503.

Transcatheter aortic valve replacement versus surgical valve replacement in intermediate-risk patients: a propensity score analysis. Thourani VH, Kodali S, Makkar RR, Herrmann HC, Williams M, Babaliaros V, Smalling R, Lim S, Malaisrie SC, Kapadia S, Szeto WY, Greason KL, Kereiakes D, Ailawadi G, Whisenant BK, Devireddy C, Leipsic J, Hahn RT, Pibarot P, Weissman NJ, Jaber WA,.. Lancet. 2016;387(10034):2218-2225.

Prostate-specific membrane antigen-targeted liposomes specifically deliver the Zn(2+) chelator TPEN inducing oxidative stress in prostate cancer cells. Stuart CH, Singh R, Smith TL, D'Agostino R Jr, Caudell D, Balaji KC, Gmeiner WH.. Nanomedicine (Lond). 2016;11(10):1207-1222.

Gene expression signatures of effector immune cell abundance are significantly associated with recurrence risk in colon cancer [abstract]. Alistar AT, Chifman J, D'Agostino R Jr, Miller LD.. Cancer Immunol Res. 2016;4(1 Suppl):A011.

A novel R848-conjugated inactivated influenza virus vaccine is efficacious and safe in a neonate nonhuman primate model. Holbrook BC, Kim JR, Blevins LK, Jorgensen MJ, Kock ND, D'Agostino RB Jr, Aycock ST, Hadimani MB, King SB, Parks GD, Alexander-Miller MA.. J Immunol. 2016;197(2):555-564.

The mitochondrial metabolism inhibitor CPI-613 in combination with mFOLFIRINOX for pancreatic adenocarcinoma [abstract]. Alistar AT, Desnoyer R, D'Agostino R.. J Clin Oncol. 2016;34(4 Suppl):264.

Simultaneous targeting of Eph receptors in glioblastoma. Ferluga S, Tome CM, Herpai DM, D'Agostino R, Debinski W.. Oncotarget. 2016;7(37):59860-76.

Anthracycline-associated T1 mapping characteristics are elevated independent of the presence of cardiovascular comorbidities in cancer survivors. Jordan JH, Vasu S, Morgan TM, D'Agostino RB Jr, Melendez GC, Hamilton CA, Arai AE, Liu S, Liu CY, Lima JA, Bluemke DA, Burke GL, Hundley WG.. Circ Cardiovasc Imaging. 2016;9(8):e004325.

Adjuvanting an inactivated influenza vaccine with flagellin improves the function and quantity of the long-term antibody response in a nonhuman primate neonate model. Holbrook BC, D'Agostino RB Jr, Parks GD, Alexander-Miller MA.. Vaccine. 2016;34(39):4712-4717.

A novel R848-conjugated inactivated influenza virus vaccine is safe and efficacious in a neonate nonhuman primate model [abstract]. Holbrook B, Kim J, Blevins L, Jorgensen M, Kock N, D'Agostino R Jr, Aycock ST, Hadimani M, King SB, Parks G, Alexander-Miller M.. Eur J Immunol. 2016;46(Suppl 1):31.

5-alpha reductase inhibitors and the risk of prostate cancer mortality in men treated for benign prostatic hyperplasia. Wallner LP, DiBello Jr, Li BH, Van Den Eeden SK, Weinmann S, Ritzwoller DP, Abell JE, D'Agostino R Jr, Loo RK, Aaronson DS, Richert-Boe K, Horwitz RI, Jacobsen SJ.. Mayo Clin Proc. 2016;91(12):1717-1726.

Comparing two waist-to-height ratio measurements with cardiometabolic risk factors among youth with diabetes. Liu LL, Kahn HS, Pettitt DJ, Fino NF, Morgan T, Maahs DM, Crimmins NA, Lamichhane AP, Liese AD, D'Agostino RB Jr, Bell RA.. Int J Child Health Nutr. 2016;5(3):87-94.

CPI-613 enhances FOLFIRINOX response rate in stage IV pancreatic cancer [abstract]. Alistar AT, Desnoyers R, D'Agostino RJ, Pasche B.. Ann Oncol. 2016;27(Suppl 6):675P.

Chronic statin administration may attenuate early anthracycline-associated declines in left ventricular ejection function. Chotenimitkhun R, D'Agostino R Jr, Lawrence JA, Hamilton CA, Jordan JH, Vasu S, Lash TL, Yeboah J, Herrington DM, Hundley WG.. Can J Cardiol. 2015;31(3):302-307.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Biostatistical Sciences

Clinical Interests

Lung Cancer, Cancer Prevention, Epidemiology, Head and Neck Cancers, Pediatric Trauma, Cancer Symptom Management, Prostate Cancer, Diabetes, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus in Adolescents
Ralph B. D'Agostino Jr, Ph.D.

Ralph B. D'Agostino Jr, Ph.D.

Core Director, Comprehensive Cancer Center
Professor, Biostatistical Sciences
Institute for Regenerative Medicine
Office of Research

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