Ralph B. D'Agostino Jr, Ph.D.Wake Forest School of Medicine

Ralph B. D'Agostino Jr, Ph.D.

Core Director,

Clinical Interests

Lung Cancer, Cancer Prevention, Epidemiology, Head and Neck Cancers, Pediatric Trauma, Cancer Symptom Management, Prostate Cancer, Diabetes, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus in Adolescents, Breast Cancer

Contact Information

Academic: 336-716-9410 | Department: 336-716-2011


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Education & Training

  • A.B., Bowdoin College, 1988
  • A.M., Harvard University, 1989
  • Ph.D., Harvard University, 1994
Ralph B. D'Agostino Jr, Ph.D.

Ralph B. D'Agostino Jr, Ph.D.

Core Director, Comprehensive Cancer Center
Professor, Biostatistical Sciences
Comprehensive Cancer Center
Institute for Regenerative Medicine
Translational Science Institute

Research Interests

cardiac function, diabetes, education/training (all f, t,, epidemiology, statistics/mathematics

Contact Information

Academic: 336-716-9410 | Department: 336-716-2011


Related Links

Recent Publications

Chotenimitkhun R, D'Agostino R Jr, Lawrence JA, Hamilton CA, Jordan JH, Vasu S, Lash TL, Yeboah J, Herrington DM, Hundley WG. Chronic statin administration may attenuate early anthracycline-associated declines in left ventricular ejection function. Can J Cardiol. 2015;31(3):302-307.

Il'yasova D, Wagenknecht LE, Spasojevic I, Watkins S, Bowden D, Wang F, D'Agostino RB Jr. Urinary F2-isoprostanes and metabolic markers of fat oxidation. Oxid Med Cell Longev. 2015;2015():729191.

Law JR, Stafford JM, D'Agostino RB Jr, Badaru A, Crume TL, Dabelea D, Dolan LM, Lawrence JM, Pettitt DJ, Mayer-Davis EJ. Association of parental history of diabetes with cardiovascular disease risk factors in children with type 2 diabetes. J Diabetes Complications. 2015;29(4):534-539.

Shah AS, Black S, Wadwa RP, Schmiege SJ, Fino NF, Talton JW, D'Agostino R Jr, Hamman RF, Urbina EM, Dolan LM, Daniels SR, Marcovina SM, Dabelea D. Insulin sensitivity and arterial stiffness in youth with type 1 diabetes: the SEARCH CVD study. J Diabetes Complications. 2015;29(4):512-516.

Henry CJ, Sedjo RL, Rozhok A, Salstrom J, Ahnen D, Levin TR, D'Agostino R Jr, Haffner S, DeGregori J, Byers T. Lack of significant association between serum inflammatory cytokine profiles and the presence of colorectal adenoma. BMC Cancer. 2015;15():123.

Tomer Y, Dolan LM, Kahaly G, Divers J, D'Agostino RB Jr, Imperatore G, Dabelea D, Marcovina S, Black MH, Pihoker C, Hasham A, Hammerstad SS, Greenberg DA, Lotay V, Zhang W, Monti MC, Matheis N. Genome wide identification of new genes and pathways in patients with both autoimmune thyroiditis and type 1 diabetes. J Autoimmun. 2015;60():32-39.

Kim JR, Holbrook BC, Hayward SL, Blevins LK, Jorgensen MJ, Kock ND, De Paris K, D'Agostino R Jr, Aycock ST, Mizel SB, Parks GD, Alexander-Miller MA. Inclusion of flagellin during vaccination against influenza enhances recall responses in nonhuman primate neonates. J Virol. 2015;89(14):7291-7303.

Jordan JH, Vasu S, Morgan T, D'Agostino R, Melendez GC, Hall M, Hamilton C, Arai A, Liu S, Liu C-Y, Lima J, Bluemke D, Hundley W. Myocardial extracellular volume is elevated in cancer survivors treated with anthracycline-based chemotherapy compared to cancer-free peers and newly diagnosed and untreated cancer patients: a single-center observational study of the. J Am Coll Cardiol. 2015;65(10 Suppl):A1081.

Saydah SH, Imperatore G, Henkin L, D'Agostino R Jr, Divers J, Mayer-Davis EJ, Dabelea D, Klingensmith G, Pihoker C, Lawrence JM. Trends and characteristics of self-reported case presentation of diabetes diagnosis among youth from 2002 to 2010: findings from the SEARCH for Diabetes in Youth Study [letter]. Diabetes Care. 2015;38(6):e84-e85.

Shah AS, Dolan LM, Dabelea D, Stafford JM, D'Agostino RB Jr, Mayer-Davis EJ, Marcovina S, Imperatore G, Wadwa RP, Daniels SR, Reynolds K, Hamman RF, Bowlby DA, Maahs DM, Wagenknecht LE. Change in adiposity minimally affects the lipid profile in youth with recent onset type 1 diabetes. Pediatr Diabetes. 2015;16(4):280-286.

Westcott MM, Liu J, Rajani K, D'Agostino R Jr, Lyles DS, Porosnicu M. Interferon beta and interferon alpha 2a differentially protect head and neck cancer cells from vesicular stomatitis virus-induced oncolysis. J Virol. 2015;89(15):7944-7954.

Li C, Beech B, Crume T, D'Agostino RB Jr, Dabelea D, Kaar JL, Liese AD, Mayer-Davis EJ, Pate R, Pettitt DJ, Taplin C, Rodriguez B, Merchant AT. Longitudinal association between television watching and computer use and risk markers in diabetes in the SEARCH for Diabetes in Youth Study. Pediatr Diabetes. 2015;16(5):382-391.

Shah AS, Wadwa RP, Dabelea D, Hamman RF, D'Agostino R Jr, Marcovina S, Daniels SR, Dolan LM, Fino NF, Urbina EM. Arterial stiffness in adolescents and young adults with and without type 1 diabetes: the SEARCH CVD study. Pediatr Diabetes. 2015;16(5):367-374.

Dabelea D, Lawrence JM, Pihoker C, Dolan L, D'Agostino RB Jr, Marcovina S, Mayer-Davis EJ. Re: 'prevalence of diagnosed and undiagnosed type 2 diabetes mellitus among US adolescents: results from the continuous NHANES, 1999-2010' [letter]. Am J Epidemiol. 2014;179(3):396-397.

Gralnek IM, Siersema PD, Halpern Z, Segol O, Melhem A, Suissa A, Santo E, Sloyer A, Fenster J, Moons LM, Dik VK, D'Agostino RB Jr, Rex DK. Standard forward-viewing colonoscopy versus full-spectrum endoscopy: an international, multicentre, randomised, tandem colonoscopy trial. Lancet Oncol. 2014;15(3):353-360.

Jaacks LM, Bell RA, Dabelea D, D'Agostino RB Jr, Dolan LM, Imperatore G, Klingensmith G, Lawrence JM, Saydah S, Yi-Frazier J, Mayer-Davis EJ. Diabetes self-management education patterns in a US population-based cohort of youth with type 1 diabetes. Diabetes Educ. 2014;40(1):29-39.

Wang W, Deng Z, Hatcher H, Miller LD, Di X, Tesfay L, Sui G, D'Agostino RB Jr, Torti FM, Torti SV. IRP2 regulates breast tumor growth. Cancer Res. 2014;74(2):497-507.

Hassan S, Karpova Y, Flores A, D'Agostino R Jr, Danhauer SC, Hemal A, Kulik G. A pilot study of blood epinephrine levels and CREB phosphorylation in men undergoing prostate biopsies. Int Urol Nephrol. 2014;46(3):505-510.

Ghosh S, Ucer KB, D'Agostino R Jr, Grant K, Sirintrapun J, Thomas MJ, Hantgan R, Bharadwaj M, Gmeiner WH. Non-covalent assembly of meso-tetra-4-pyridyl porphine with single-stranded DNA to form nano-sized complexes with hydrophobicity-dependent DNA release and anti-tumor activity. Nanomedicine (Lond). 2014;10(2):451-461.

Jaacks LM, Crandell J, Liese AD, Lamichhane AP, Bell RA, Dabelea D, D'Agostino RB Jr, Dolan LM, Marcovina S, Reynolds K, Shah AS, Urbina EM, Wadwa RP, Mayer-Davis EJ. No association of dietary fiber intake with inflammation or arterial stiffness in youth with type 1 diabetes. J Diabetes Complications. 2014;28(3):305-310.

Bryan M, D'Agostino R, Brown D, Levine E, Howard-McNatt M. Is postmastectomy radiation therapy indicated in patients with close or positive margins? [abstract]. Ann Surg Oncol. 2014;21(Suppl 2):33.

Shah AS, Dabelea D, Talton JW, Urbina EM, D Agostino RB Jr, Wadwa RP, Marcovina S, Hamman RF, Daniels SR, Dolan LM. Smoking and arterial stiffness in youth with type 1 diabetes: The SEARCH Cardiovascular Disease Study. J Pediatr. 2014;165(1):110-116.

Dabelea D, Rewers A, Stafford JM, Standiford DA, Lawrence JM, Saydah S, Imperatore G, D'Agostino RB Jr, Mayer-Davis EJ, Pihoker C. Trends in the prevalence of ketoacidosis at diabetes diagnosis: the SEARCH for Diabetes in Youth Study. Pediatrics. 2014;133(4):E938-E945.

Hundley WG, D'Agostino RB, Hamilton CA, inventors; Wake Forest University Health Sciences, assignee. Workstations with circutis for generating images of global injury. United States patent US 8,660,327. 2014 Feb 25. 2014;():.

Lawrence JM, Imperatore G, Dabelea D, Mayer-Davis EJ, Linder B, Saydah S, Klingensmith GJ, Dolan L, Standiford DA, Pihoker C, Pettitt DJ, Talton JW, Thomas J, Bell RA, D'Agostino RB Jr. Trends in incidence of type 1 diabetes among non-Hispanic white youth in the United States, 2002-2009. Diabetes. 2014;63(11):3938-3945.

Fortunato JE, Wagoner AL, Harbinson RL, D'Agostino RB Jr, Shaltout HA, Diz DI. Effect of fludrocortisone acetate on chronic unexplained nausea and abdominal pain in children with orthostatic intolerance. J Pediatr Gastroenterol Nutr. 2014;59(1):39-43.

Vatca M, Lucas JT Jr, Laudadio J, D'Agostino RB, Waltonen JD, Sullivan CA, Rouchard-Plasser R, Matsangou M, Browne JD, Greven KM, Porosnicu M. Retrospective analysis of the impact of HPV status and smoking on mucositis in patients with oropharyngeal squamous cell carcinoma treated with concurrent chemotherapy and radiotherapy. Oral Oncol. 2014;50(9):869-876.

Choi JS, Kim EY, Kim MJ, Khan FA, Giegengack M, D'Agostino R Jr, Criswell T, Khang G, Soker S. Factors affecting successful isolation of human corneal endothelial cells for clinical use. Cell Transplant. 2014;23(7):845-854.

Yosipovitch G, Mills KC, Nattkemper LA, Feneran A, Liang TH, Lowenthal BM, Pearce DJ, Williford PM, Sangueza OP, D'Agostino RB Jr. Association of pain and itch with depth of invasion and inflammatory cell constitution in skin cancer: results of a large clinicopathologic study. JAMA Dermatol. 2014;150(11):1160-1166.

Jordan JH, D'Agostino RB Jr, Hamilton CA, Vasu S, Hall ME, Kitzman DW, Thohan V, Lawrence JA, Ellis LR, Lash TL, Hundley WG. Longitudinal assessment of concurrent changes in left ventricular ejection fraction and left ventricular myocardial tissue characteristics after administration of cardiotoxic chemotherapies using T1-weighted and T2-weighted cardiovascular magnetic. Circ Cardiovasc Imaging. 2014;7(6):872-879.

Valenzuela JM, Smith LB, Stafford JM, D'Agostino RB Jr, Lawrence JM, Yi-Frazier JP, Seid M, Dolan LM. Shared decision-making among caregivers and health care providers of youth with type 1 diabetes. J Clin Psychol Med Settings. 2014;21(3):234-243.

Andrews EB, Thomas J, Jaacks L, D'Agostino R Jr, Ward D, Mayer-Davis EJ. Patient perception of midlevel providers in pediatric diabetes care. Diabetes Educ. 2014;40(3):329-335.

Greene-Schloesser DM, Kooshki M, Payne V, D'Agostino RB Jr, Wheeler KT, Metheny-Barlow LJ, Robbins ME [deceased]. Cellular response of the rat brain to single doses of (137)Cs gamma rays does not predict its response to prolonged 'biologically equivalent' fractionated doses. Int J Radiat Biol. 2014;90(9):790-798.

Mays AC, Moustafa F, Worley M, Waltonen JD, D'Agostino R Jr. A model for predicting gastrostomy tube placement in patients undergoing surgery for upper aerodigestive tract lesions. JAMA Otolaryngol Head Neck Surg. 2014;140(12):1198-1206.

Wheeler KT, Payne V, D'Agostino RB Jr, Walb MC, Munley MT, Metheny-Barlow LJ, Robbins ME [deceased]. Impact of breathing 100% oxygen on radiation-induced cognitive impairment. Radiat Res. 2014;182(5):580-585.

Alistar A, Chou JW, Nagalla S, Black MA, D'Agostino R Jr, Miller LD. Dual roles for immune metagenes in breast cancer prognosis and therapy prediction. Genome Med. 2014;6(10):80.

Hamman RF, Bell RA, Dabelea D, D'Agostino RB Jr, Dolan L, Imperatore G, Lawrence JM, Linder B, Marcovina SM, Mayer-Davis EJ, Pihoker C, Rodriguez BL, Saydah S. The SEARCH for Diabetes in Youth study: rationale, findings, and future directions. Diabetes Care. 2014;37(12):3336-3344.

Alman AC, Talton JW, Wadwa RP, Urbina EM, Dolan LM, Daniels SR, Hamman RF, D'Agostino RB, Marcovina SM, Mayer-Davis EJ, Dabelea DM. Cardiovascular health in adolescents with type 1 diabetes: the SEARCH CVD study. Pediatr Diabetes. 2014;15(7):502-510.

Gmeiner WH, Willingham MC, Bourland JD, Hatcher HC, Smith TL, D'Agostino RB Jr, Blackstock W. F10 inhibits growth of PC3 xenografts and enhances the effects of radiation therapy. J Clin Oncol Res. 2014;2(4):1028.

Blackham AU, Northrup SA, Willingham M, D'Agostino RB Jr, Lyles DS, Stewart JH IV. Variation in susceptibility of human malignant melanomas to oncolytic vesicular stomatitis virus. Surgery. 2013;153(3):333-343.

Maahs DM, Dabelea D, D'Agostino RB Jr, Andrews JS, Shah AS, Crimmins N, Mayer-Davis EJ, Marcovina S, Imperatore G, Wadwa RP, Daniels SR, Reynolds K, Hamman RF, Dolan LM. Glucose control predicts 2-year change in lipid profile in youth with type 1 diabetes. J Pediatr. 2013;162(1):101-107.

Eckman DM, Stacey RB, Rowe R, D'Agostino R Jr, Kock ND, Sane DC, Torti FM, Yeboah J, Workman S, Lane KS, Hundley WG. Weekly doxorubicin increases coronary arteriolar wall and adventitial thickness. PLoS One. 2013;8(2):e57554.

Jaiswal M, Urbina EM, Wadwa RP, Talton JW, D'Agostino RB Jr, Hamman RF, Fingerlin TE, Daniels S, Marcovina SM, Dolan LM, Dabelea D. Reduced heart rate variability among youth with type 1 diabetes: the SEARCH CVD study. Diabetes Care. 2013;36(1):157-162.

Naik S, D'Agostino R Jr, Knovich MA, Grier D, Harrelson R, McPhail L. Impact of iron overload on immune function for patients undergoing allogeneic transplants for hematologic disorders: results of pilot study [abstract]. Biol Blood Marrow Transplant. 2013;19(2 Suppl 2):S300-S301.

Quandt SA, Grzywacz JG, Talton JW, Trejo G, Tapia J, D'Agostino RB Jr, Mirabelli MC, Arcury TA. Evaluating the effectiveness of a lay health promoter-led, community-based participatory pesticide safety intervention with farmworker families. Health Promot Pract. 2013;14(3):425-432.

Kwatra SG, Mills KC, Lowenthal B, Pearce DJ, Williford PM, Sangueza OP, D'Agostino RB, Yosipovitch G. Itch and pain are prognostic markers for depth of invasion and inflammatory cell constitution in nonmelanoma skin cancer: Results of a large clinicopathological study [abstract]. J Invest Dermatol. 2013;133(Suppl 1):S180.

Rugo HS, Serrurier K, Melisko M, Glencer A, Hwang J, D'Agostino R, Hutchens S, Esserman L, Melin S. The Dignicap System to prevent alopecia in women receiving chemotherapy for breast cancer [abstract]. Breast. 2013;22(Suppl 1):S119.

Hassan S, Karpova Y, Baiz D, Yancey D, Pullikuth A, Flores A, Register T, Cline JM, D'Agostino R Jr, Danial N, Datta SR, Kulik G. Behavioral stress accelerates prostate cancer development in mice. J Clin Invest. 2013;123(2):874-886.

Wang W, Deng ZY, Hatcher H, Miller L, Di XM, Tesfay L, D'Agostino RB Jr, Torti S, Torti F. Irp2 regulates tumor growth in breast cancer [abstract]. Am J Hematol. 2013;88(5):E15.

Drafts BC, Twomley KM, D'Agostino R Jr, Lawrence J, Avis N, Ellis LR, Thohan V, Jordan J, Melin SA, Torti FM, Little WC, Hamilton CA, Hundley WG. Low to moderate dose anthracycline-based chemotherapy is associated with early noninvasive imaging evidence of subclinical cardiovascular disease. JACC Cardiovasc Imaging. 2013;6(8):877-885.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Biostatistical Sciences

Clinical Interests

Lung Cancer, Cancer Prevention, Epidemiology, Head and Neck Cancers, Pediatric Trauma, Cancer Symptom Management, Prostate Cancer, Diabetes, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus in Adolescents, Breast Cancer

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