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Swapan K. Das, Ph.D.Wake Forest School of Medicine

Swapan K. Das, Ph.D.

Assistant Professor,

Contact Information

Academic: 336-713-6528 | Department: 336-713-6057

Education & Training

  • B.S., University Of Calcutta-India, 1991
  • Ph.D., University Of Calcutta-India, 2000
Swapan K. Das, Ph.D.

Swapan K. Das, Ph.D.

Assistant Professor, Endocrinology and Metabolism
Center on Diabetes, Obesity, and Metabolism

Research Interests

Insulin Resistance; Adipose Tissue; Diabetes Mellitus, Type 2; Polymorphism, Single Nucleotide; Chromosomes, Human, Pair 1
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Contact Information

Academic: 336-713-6528 | Department: 336-713-6057

Recent Publications

The African Descent and Glaucoma Evaluation Study (ADAGES) III: contribution of genotype to glaucoma phenotype in African Americans: study design and baseline data. Zangwill LM, Ayyagari R, Liebmann JM, Girkin CA, Feldman R, Dubiner H, Dirkes KA, Holmann M, Williams-Steppe E, Hammel N, Saunders LJ, Vega S, Sandow K, Roll K, Slight R, Auerbach D, Samuels BC, Panarelli JF, Mitchell JP, Al-Aswad LA,.. Ophthalmology. 2018;():.

Transcriptional regulatory mechanisms in adipose and muscle tissue associated with composite glucometabolic phenotypes. Langefeld CD, Comeau ME, Sharma NK, Bowden DW, Freedman BI, Das SK.. Obesity (Silver Spring). 2018;26(3):559-569.

Randomized controlled trial of a MUFA or fiber-rich diet on hepatic fat in prediabetes. Errazuriz I, Dube S, Slama M, Visentin R, Nayar S, O'Connor H, Cobelli C, Das SK, Basu A, Kremers WK, Port J, Basu R.. J Clin Endocrinol Metab. 2017;102(5):1765-1774.

The TMAO-producing enzyme flavin-containing monooxygenase 3 regulates obesity and the beiging of white adipose tissue. Schugar RC, Shih DM, Warrier M, Helsley RN, Burrows A, Ferguson D, Brown AL, Gromovsky AD, Heine M, Chatterjee A, Li L, Li XS, Wang Z, Willard B, Meng Y, Kim H, Che N, Pan C, Lee RG, Crooke RM, Graham MJ, Morton RE, Langefeld CD,.. Cell Rep. 2017;19(12):2451-2461.

Genetic regulation of adipose tissue transcript expression is involved in modulating serum triglyceride and HDL-cholesterol. Sajuthi SP, Sharma NK, Comeau ME, Chou JW, Bowden DW, Freedman BI, Langefeld CD, Parks JS, Das SK.. Gene. 2017;632():50-58.

Tissue-specific and genetic regulation of insulin sensitivity-associated transcripts in African Americans. Sharma NK, Sajuthi SP, Chou JW, Calles-Escandon J, Demons J, Rogers S, Ma L, Palmer ND, R McWilliams D, Beal J, Comeau M, Cherry K, Hawkins GA, Menon L, Kouba E, Davis D, Burris M, Byerly SJ, Easter L, Bowden DW, Freedman BI, Langefeld CD, Das SK.. J Clin Endocrinol Metab. 2016;101(4):1455-1468.

Mapping adipose and muscle tissue expression quantitative trait loci in African Americans to identify genes for type 2 diabetes and obesity. Sajuthi SP, Sharma NK, Chou JW, Palmer ND, McWilliams DR, Beal J, Comeau ME, Ma L, Calles-Escandon J, Demons J, Rogers S, Cherry K, Menon L, Kouba E, Davis D, Burris M, Byerly SJ, Ng MC, Maruthur NM, Patel SR, Bielak LF, Lange LA, Guo X, Sale MM,.. Hum Genet. 2016;135(8):869-880.

Omics analysis of adiponectin in African Americans to elucidate the biology underlying metabolic disease [abstract]. Palmer ND, Sajuthi S, Sharma N, Chou J, Bowden DW, Freedman BI, Langefeld CD, Das SK.. In: Abstracts of the 2016 Annual Meeting of the American Diabetes Association; 2016 June 10-14; New Orleans (LA). 2016;():2461.

Adipose tissue gene expression and metabolic health of obese adults. Das SK, Ma L, Sharma NK.. Int J Obes (Lond). 2015;39(5):869-873.

Integrative network analysis reveals different pathophysiological mechanisms of insulin resistance among Caucasians and African Americans. Das SK, Sharma NK, Zhang B.. BMC Med Genomics. 2015;8(1):4.

eQTL analysis of adipose and muscle in African Americans identifies genetic regulators for type 2 diabetes and obesity-associated genes [abstract]. Sajuthi S, Sharma N, McWilliams D, Chou J, Comeau M, Palmer ND, Ma L, Calles J, Demons J, Rogers S, Beal J, Menon L, Kouba E, Davis D, Byers J, Burris M, Byerly SJ, Easter L, Bowden DW, Freedman BI, Langefeld CD, Das SK.. Diabetes. 2015;64(Suppl 1):A82.

Transcriptional profiles of adipose and muscle tissue are associated with insulin sensitivity and influenced by genetic variation in African Americans [abstract]. Sharma NK, Sajuthi S, Chou J, Ma L, Calles J, Demons J, Rogers S, McWilliams D, Beal J, Comeau M, Palmer ND, Menon L, Kouba E, Davis D, Byers J, Burris M, Byerly SJ, Easter L, Bowden DW, Freedman BI, Langefeld CD, Das SK.. Diabetes. 2015;64(Suppl 1):A456.

Obesity associated modulation of miRNA and co-regulated target transcripts in human adipose tissue of non-diabetic subjects. Sharma NK, Varma V, Ma L, Hasstedt SJ, Das SK.. Microrna. 2015;4(3):194-204.

Expression quantitative trait analyses to identify causal genetic variants for type 2 diabetes susceptibility. Das SK, Sharma NK.. World J Diabetes. 2014;5(2):97-114.

Integrating transcriptome and epigenome: putting together the pieces of the type 2 diabetes pathogenesis puzzle [editorial]. Das SK.. Diabetes. 2014;63(9):2901-2903.

Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation. Cao Q, Wang X, Jia L, Mondal AK, Diallo A, Hawkins GA, Das SK, Parks JS, Yu L, Shi H, Shi H, Xue B.. Endocrinology. 2014;155(12):4925-4938.

An ACACB variant implicated in diabetic nephropathy associates with body mass index and gene expression in obese subjects. Ma L, Murea M, Snipes JA, Marinelarena A, Kruger J, Hicks PJ, Langberg KA, Bostrom MA, Cooke JN, Suzuki D, Babazono T, Uzu T, Tang SC, Mondal AK, Sharma NK, Kobes S, Antinozzi PA, Davis M, Das SK, Rasouli N, Kern PA,.. PLoS One. 2013;8(2):e56193.

Phospholipid biosynthesis genes and susceptibility to obesity: analysis of expression and polymorphisms. Sharma NK, Langberg KA, Mondal AK, Das SK.. PLoS One. 2013;8(5):e65303.

Five linkage regions each harbor multiple type 2 diabetes genes in the African American subset of the GENNID Study. Hasstedt SJ, Highland HM, Elbein SC [deceased], Hanis CL, Das SK, et al.. J Hum Genet. 2013;58(6):378-383.

Allelic expression imbalance screening of genes in chromosome 1q21-24 region to identify functional variants for Type 2 diabetes susceptibility. Mondal AK, Sharma NK, Elbein SC [deceased], Das SK.. Physiol Genomics. 2013;45(13):509-520.

Single nucleotide polymorphisms in JAZF1 and BCL11A gene are nominally associated with type 2 diabetes in African-American families from the GENNID study. Langberg KA, Ma L, Sharma NK, Hanis CL, Elbein SC [deceased], Hasstedt SJ, Das SK.. J Hum Genet. 2012;57(1):57-61.

Quadruplex-single nucleotide polymorphisms (Quad-SNP) influence gene expression difference among individuals. Baral A, Kumar P, Halder R, Mani P, Yadav VK, Singh A, Das SK, Chowdhury S.. Nucleic Acids Res. 2012;40(9):3800-3811.

Improved insulin sensitivity after treatment with PPAR gamma and PPAR alpha ligands is mediated by genetically modulated transcripts. Rasouli N, Kern PA, Elbein SC [deceased], Sharma NK, Das SK.. Pharmacogenet Genomics. 2012;22(7):484-497.

Effect of endoplasmic reticulum stress on inflammation and adiponectin regulation in human adipocytes. Mondal AK, Das SK, Varma V, Nolen GT, McGehee RE, Elbein SC [deceased], Wei JY, Ranganathan G.. Metab Syndr Relat Disord. 2012;10(4):297-306.

Genetic risk factors for type 2 diabetes: a trans-regulatory genetic architecture?. Elbein SC [deceased], Gamazon ER, Das SK, Rasouli N, Kern PA, Cox NJ.. Am J Hum Genet. 2012;91(3):466-477.

Global gene expression profiles of subcutaneous adipose and muscle from glucose-tolerant, insulin-sensitive, and insulin-resistant individuals matched for BMI. Elbein SC [deceased], Kern PA, Rasouli N, Yao-Borengasser A, Sharma NK, Das SK.. Diabetes. 2011;60(3):1019-1029.

Type 2 diabetes (T2D) associated polymorphisms regulate expression of adjacent transcripts in transformed lymphocytes, adipose, and muscle from Caucasian and African-American subjects. Sharma NK, Langberg KA, Mondal AK, Elbein SC [deceased], Das SK.. J Clin Endocrinol Metab. 2011;96(2):E394-E403.

An integrative genomics approach identifies activation of thioredoxin/thioredoxin reductase-1-mediated oxidative stress defense pathway and inhibition of angiogenesis in obese nondiabetic human subjects. Das SK, Sharma NK, Hasstedt SJ, Mondal AK, Ma L, Langberg KA, Elbein SC [deceased].. J Clin Endocrinol Metab. 2011;96(8):E1308-1313.

Pleiotropy of type 2 diabetes with obesity. Hasstedt SJ, Hanis CL, Das SK, Elbein SC [deceased].. J Hum Genet. 2011;56(7):491-495.

The effect of ACACB cis-variants on gene expression and metabolic traits. Ma L, Mondal AK, Murea M, Sharma NK, Langberg KA, Das SK, Antinozzi PA, Parks JS, Elbein SC [deceased], Freedman BI, et al.. PLoS ONE. 2011;6(8):e23860.

Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humans. Mondal AK, Das SK, Baldini G, Chu WS, Sharma NK, Hackney OG, Zhao J, Grant SFA, Elbein SC.. J Clin Endocrinol Metab. 2010;95(3):1450-1457.

Analysis of osteocalcin as a candidate gene for type 2 diabetes (T2D) and intermediate traits in Caucasians and African Americans. Das SK, Sharma NK, Elbein SC [deceased].. Dis Markers. 2010;28(5):281-286.

Distinct gene expression profiles characterize cellular responses to palmitate and oleate. Das SK, Mondal AK, Elbein SC [deceased].. J Lipid Res. 2010;51(8):2121-2131.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Endocrinology and Metabolism

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