Swapan K. Das, Ph.D.Wake Forest School of Medicine

Swapan K. Das, Ph.D.

Assistant Professor,

Contact Information

Academic: 336-713-6528 | Department: 336-713-6057

Education & Training

  • B.S., University Of Calcutta-India, 1991
  • Ph.D., University Of Calcutta-India, 2000
Swapan K. Das, Ph.D.

Swapan K. Das, Ph.D.

Assistant Professor, Endocrinology and Metabolism
Center on Diabetes, Obesity, and Metabolism

Research Interests

diabetes, genetics/genome, metabolism, minority health issues, molecular biology/molecular me

Contact Information

Academic: 336-713-6528 | Department: 336-713-6057

Recent Publications

Sharma NK, Sajuthi SP, Chou JW, Calles-Escandon J, Demons J, Rogers S, Ma L, Palmer ND, R McWilliams D, Beal J, Comeau M, Cherry K, Hawkins GA, Menon L, Kouba E, Davis D, Burris M, Byerly SJ, Easter L, Bowden DW, Freedman BI, Langefeld CD, Das SK. Tissue-specific and genetic regulation of insulin sensitivity-associated transcripts in African Americans. J Clin Endocrinol Metab. 2016;101(4):1455-1468.

Sajuthi SP, Sharma NK, Chou JW, Palmer ND, McWilliams DR, Beal J, Comeau ME, Ma L, Calles-Escandon J, Demons J, Rogers S, Cherry K, Menon L, Kouba E, Davis D, Burris M, Byerly SJ, Ng MC, Maruthur NM, Patel SR, Bielak LF, Lange LA, Guo X, Sale MM,. Mapping adipose and muscle tissue expression quantitative trait loci in African Americans to identify genes for type 2 diabetes and obesity. Hum Genet. 2016;():.

Das SK, Ma L, Sharma NK. Adipose tissue gene expression and metabolic health of obese adults. Int J Obes (Lond). 2015;39(5):869-873.

Das SK, Sharma NK, Zhang B. Integrative network analysis reveals different pathophysiological mechanisms of insulin resistance among Caucasians and African Americans. BMC Med Genomics. 2015;8(1):4.

Sajuthi S, Sharma N, McWilliams D, Chou J, Comeau M, Palmer ND, Ma L, Calles J, Demons J, Rogers S, Beal J, Menon L, Kouba E, Davis D, Byers J, Burris M, Byerly SJ, Easter L, Bowden DW, Freedman BI, Langefeld CD, Das SK. eQTL analysis of adipose and muscle in African Americans identifies genetic regulators for type 2 diabetes and obesity-associated genes [abstract]. Diabetes. 2015;64(Suppl 1):A82.

Sharma NK, Sajuthi S, Chou J, Ma L, Calles J, Demons J, Rogers S, McWilliams D, Beal J, Comeau M, Palmer ND, Menon L, Kouba E, Davis D, Byers J, Burris M, Byerly SJ, Easter L, Bowden DW, Freedman BI, Langefeld CD, Das SK. Transcriptional profiles of adipose and muscle tissue are associated with insulin sensitivity and influenced by genetic variation in African Americans [abstract]. Diabetes. 2015;64(Suppl 1):A456.

Sharma NK, Varma V, Ma L, Hasstedt SJ, Das SK. Obesity associated modulation of miRNA and co-regulated target transcripts in human adipose tissue of non-diabetic subjects. Microrna. 2015;4(3):194-204.

Das SK, Sharma NK. Expression quantitative trait analyses to identify causal genetic variants for type 2 diabetes susceptibility. World J Diabetes. 2014;5(2):97-114.

Das SK. Integrating transcriptome and epigenome: putting together the pieces of the type 2 diabetes pathogenesis puzzle [editorial]. Diabetes. 2014;63(9):2901-2903.

Cao Q, Wang X, Jia L, Mondal AK, Diallo A, Hawkins GA, Das SK, Parks JS, Yu L, Shi H, Shi H, Xue B. Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation. Endocrinology. 2014;155(12):4925-4938.

Ma L, Murea M, Snipes JA, Marinelarena A, Kruger J, Hicks PJ, Langberg KA, Bostrom MA, Cooke JN, Suzuki D, Babazono T, Uzu T, Tang SC, Mondal AK, Sharma NK, Kobes S, Antinozzi PA, Davis M, Das SK, Rasouli N, Kern PA,. An ACACB variant implicated in diabetic nephropathy associates with body mass index and gene expression in obese subjects. PLoS One. 2013;8(2):e56193.

Sharma NK, Langberg KA, Mondal AK, Das SK. Phospholipid biosynthesis genes and susceptibility to obesity: analysis of expression and polymorphisms. PLoS One. 2013;8(5):e65303.

Hasstedt SJ, Highland HM, Elbein SC [deceased], Hanis CL, Das SK, et al. Five linkage regions each harbor multiple type 2 diabetes genes in the African American subset of the GENNID Study. J Hum Genet. 2013;58(6):378-383.

Mondal AK, Sharma NK, Elbein SC [deceased], Das SK. Allelic expression imbalance screening of genes in chromosome 1q21-24 region to identify functional variants for Type 2 diabetes susceptibility. Physiol Genomics. 2013;45(13):509-520.

Langberg KA, Ma L, Sharma NK, Hanis CL, Elbein SC [deceased], Hasstedt SJ, Das SK. Single nucleotide polymorphisms in JAZF1 and BCL11A gene are nominally associated with type 2 diabetes in African-American families from the GENNID study. J Hum Genet. 2012;57(1):57-61.

Baral A, Kumar P, Halder R, Mani P, Yadav VK, Singh A, Das SK, Chowdhury S. Quadruplex-single nucleotide polymorphisms (Quad-SNP) influence gene expression difference among individuals. Nucleic Acids Res. 2012;40(9):3800-3811.

Rasouli N, Kern PA, Elbein SC [deceased], Sharma NK, Das SK. Improved insulin sensitivity after treatment with PPAR gamma and PPAR alpha ligands is mediated by genetically modulated transcripts. Pharmacogenet Genomics. 2012;22(7):484-497.

Mondal AK, Das SK, Varma V, Nolen GT, McGehee RE, Elbein SC [deceased], Wei JY, Ranganathan G. Effect of endoplasmic reticulum stress on inflammation and adiponectin regulation in human adipocytes. Metab Syndr Relat Disord. 2012;10(4):297-306.

Elbein SC [deceased], Gamazon ER, Das SK, Rasouli N, Kern PA, Cox NJ. Genetic risk factors for type 2 diabetes: a trans-regulatory genetic architecture?. Am J Hum Genet. 2012;91(3):466-477.

Elbein SC [deceased], Kern PA, Rasouli N, Yao-Borengasser A, Sharma NK, Das SK. Global gene expression profiles of subcutaneous adipose and muscle from glucose-tolerant, insulin-sensitive, and insulin-resistant individuals matched for BMI. Diabetes. 2011;60(3):1019-1029.

Sharma NK, Langberg KA, Mondal AK, Elbein SC [deceased], Das SK. Type 2 diabetes (T2D) associated polymorphisms regulate expression of adjacent transcripts in transformed lymphocytes, adipose, and muscle from Caucasian and African-American subjects. J Clin Endocrinol Metab. 2011;96(2):E394-E403.

Das SK, Sharma NK, Hasstedt SJ, Mondal AK, Ma L, Langberg KA, Elbein SC [deceased]. An integrative genomics approach identifies activation of thioredoxin/thioredoxin reductase-1-mediated oxidative stress defense pathway and inhibition of angiogenesis in obese nondiabetic human subjects. J Clin Endocrinol Metab. 2011;96(8):E1308-1313.

Hasstedt SJ, Hanis CL, Das SK, Elbein SC [deceased]. Pleiotropy of type 2 diabetes with obesity. J Hum Genet. 2011;56(7):491-495.

Ma L, Mondal AK, Murea M, Sharma NK, Langberg KA, Das SK, Antinozzi PA, Parks JS, Elbein SC [deceased], Freedman BI, et al. The effect of ACACB cis-variants on gene expression and metabolic traits. PLoS ONE. 2011;6(8):e23860.

Mondal AK, Das SK, Baldini G, Chu WS, Sharma NK, Hackney OG, Zhao J, Grant SFA, Elbein SC. Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humans. J Clin Endocrinol Metab. 2010;95(3):1450-1457.

Das SK, Sharma NK, Elbein SC [deceased]. Analysis of osteocalcin as a candidate gene for type 2 diabetes (T2D) and intermediate traits in Caucasians and African Americans. Dis Markers. 2010;28(5):281-286.

Das SK, Mondal AK, Elbein SC [deceased]. Distinct gene expression profiles characterize cellular responses to palmitate and oleate. J Lipid Res. 2010;51(8):2121-2131.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Endocrinology and Metabolism

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