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Paul A. Dawson, Ph.D.

Paul A. Dawson, Ph.D.

Professor, Gastroenterology

Contact Information

Academic: 336-716-4633 | Department: 336-713-7777

Education & Training

  • Ph.D., SUNY-Stony Brook , 1986
  • B.S., University of Florida , 1981
  • Fellowship, University of Texas Southwestern Medical Center, 1990

Memberships

  • Aasld
  • Am Gastroenterological Assn
  • Aha - Council On Arteriosclero
  • Gastroenterology Research Grou
Paul A. Dawson, Ph.D.

Paul A. Dawson, Ph.D.

Professor, Gastroenterology

Research Interests

drugs/therapeutic agents pharm, maternal & child health, metabolism, radiology/imaging

Contact Information

Academic: 336-716-4633 | Department: 336-713-7777

Recent Publications


Debray D, Rainteau D, Barbu V, Rouahi M, El Mourabit H, Lerondel S, Rey C, Humbert L, Wendum D, Cottart CH, Dawson P, Chignard N, Housset C. Defects in gallbladder emptying and bile Acid homeostasis in mice with cystic fibrosis transmembrane conductance regulator deficiencies. Gastroenterology. 2012;142(7):1581-1591.

Lan T, Rao A, Haywood J, Kock ND, Dawson PA. Mouse organic solute transporter alpha deficiency alters FGF15 expression and bile acid metabolism. J Hepatol. 2012;57(2):359-365.

Dawson PA, Mishra G. Intrahepatic cholestasis of pregnancy In: Ibdah JA, ed. Maternal liver disease. Austin (TX): Landes Bioscience;2012: .

Rao A, Lan T, Haywood J, Dawson P. Analysis of the contribution of Mrp3 (Abcc3) to intestinal bile acid transport and the adaptive response in organic solute transporter (OST) alpha knockout mice [abstract]. Hepatology. 2012;56(Suppl 1):539A.

Dawson PA. Role of the intestinal bile acid transporters in bile acid and drug disposition. Handb Exp Pharmacol. 2011;201():169-203.


Tang W, Jia L, Ma Y, Xie P, Haywood J, Dawson PA, Li J, Yu L. Ezetimibe restores biliary cholesterol excretion in mice expressing Niemann-Pick C1-Like 1 only in liver. Biochim Biophys Acta. 2011;1811(9):549-555.

Ho RH, Leake BF, Urquhart BL, Gregor JC, Dawson PA, Kim RB. Functional characterization of genetic variants in the apical sodium-dependent bile acid transporter (ASBT; SLC10A2). J Gastroenterol Hepatol. 2011;26(12):1740-1748.

Dawson PA. Bile secretion and the enterohepatic circulation In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's gastrointestinal and liver disease: pathophysiology/diagnosis/management. 9th ed. Philadelphia: Saunders/Elsevier;2010: 1075-1088.


Dawson PA, Hubbert ML, Rao A. Getting the mOST from OST: Role of organic solute transporter, OSTalpha-OSTbeta, in bile acid and steroid metabolism. Biochim Biophys Acta. 2010;1801(9):994-1004.

Beuling E, Kerkhof IM, Nicksa GA, Giuffrida MJ, Haywood J, aan de Kerk DJ, Piaseckyj CM, Pu WT, Buchmiller TL, Dawson PA, et al. Conditional Gata4 deletion in mice induces bile acid absorption in the proximal small intestine. Gut. 2010;59(7):888-895.

Lan TA, Haywood JH, Rao A, Dawson PA. Inactivation of organic solute transporter (OST)alpha alters bile acid homeostasis via the FXR-FGF15 pathway [abstract]. Hepatology. 2010;52(4 Suppl):431A.

Miyata M, Matsuda Y, Nomoto M, Takamatsu Y, Sato N, Hamatsu M, Dawson PA, Gonzalez FJ, Yamazoe Y. Cholesterol feeding prevents hepatic accumulation of bile acids in cholic acid-fed farnesoid X receptor (FXR)-null mice: FXR-independent suppression of intestinal bile acid absorption. Drug Metab Dispos. 2009;37(2):338-344.

Dawson PA, Lan T, Rao A. Bile acid transporters. J Lipid Res. 2009;50(12):2340-2357.

Lan T, Rao A, Haywood J, Davis CB, Han C, Garver E, Dawson PA. Interaction of macrolide antibiotics with intestinally expressed human and rat organic anion-transporting polypeptides. Drug Metab Dispos. 2009;37(12):2375-2382.

Rao A, Haywood J, Dawson PA. Role of the organic solute transporter Ost alpha-Ost beta in intestinal basolateral bile acid transport and bile acid homeostasis In: Keppler D, Beuers U, Steihl A, Trauner M, eds. Bile acid biology and therapeutic actions. Proceedings of Falk Symposium 165; 2008 June 13-14; Amsterdam (The Netherlands). Dordrecht (The Netherlands): Springer;2009: 69-75.

Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA. The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis. Proc Natl Acad Sci U S A. 2008;105(10):3891-3896.

Haywood J, Rao A, Dawson P. Inactivation of the ileal bile acid transporter reduces ileal fibroblast growth factor 15 expression and limits atherosclerosis in apolipoprotein E and LDL receptor null mice [abstract]. Arterioscler Thromb Vasc Biol. 2008;28(6):e-121.

Garver E, Hugger ED, Shearn SP, Rao A, Dawson PA, Davis CB, Han C. Involvement of intestinal uptake transporters in the absorption of azithromycin and clarithromycin in the rat. Drug Metab Dispos. 2008;36(12):2492-2498.

Beuling E, Kerkhof IM, Piaseckyj CM, Dawson PA, Pu WT, Grand RJ, Krasinski SD. The absence of GATA4 in the distal small intestine defines the ileal phenotype [abstract]. Gastroenterology. 2008;134(4 Suppl 1):A83-A84.

Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA. The basolateral transporter Ost alpha-Ost beta is essential for intestinal bile acid absorption and homeostasis [abstract]. Hematology. 2007;46(4 Suppl 1):271A.

Jung D, Inagaki T, Gerard RD, Dawson PA, Kliewer SA, Mangelsdorf DJ, Moschetta A. FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption. J Lipid Res. 2007;48(12):2693-2700.

Rao A, Haywood J, Craddock AL, Dawson PA. Molecular mechanism of intestinal basolateral bile acid transport In: Keppler D, Beuers U, Leuschner U, Stiehl A, Trauner M, Paumgartner G, eds. Bile acids: biological actions and clinical relevance. Proceedings of the Falk Symposium 155; 2006 Oct 6-7; Freiberg (Germany). Dordrecht (The Netherlands): Springer;2007: 76-84.

Dawson PA. Bile secretion and the enterohepatic circulation In: Feldman M, Friedman LS, Brandt LJ, Sleisenger MH, eds. Sleisenger & Fordtran's gastrointestinal and liver disease, vol 1. 8th ed. Philadelphia (PA): Saunders Elsevier;2006: 1369-1385.

Neimark E, Chen F, Li X, Magid MS, Alasio TM, Frankenberg T, Sinha J, Dawson PA, Shneider BL. c-Fos is a critical mediator of inflammatory-mediated repression of the apical sodium-dependent bile acid transporter. Gastroenterology. 2006;131(2):554-567.

Splinter PL, Lazaridis KN, Dawson PA, LaRusso NF. Cloning and expression of SLC10A4, a putative organic anion transport protein. World J Gastroenterol. 2006;12(42):6797-6805.

Montagnani M, Abrahamsson A, Galman C, Eggertsen G, Marschall H-U, Ravaioli E, Einarsson C, Dawson PA. Analysis of ileal sodium/bile acid cotransporter and related nuclear receptor genes in a family with multiple cases of idiopathic bile acid malabsorption. World J Gastroenterol. 2006;12(47):7710-7714.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Gastroenterology

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