Profile

Samuel A. Deadwyler, Ph.D.Wake Forest School of Medicine

Education & Training

  • B.A., San Diego State Univ, 1965
  • Ph.D., SUNY-Stony Brook, 1970

Memberships

  • Am Assn Of Advancement Of Scie
  • Society for Neuroscience
Samuel A. Deadwyler, Ph.D.

Samuel A. Deadwyler, Ph.D.

Professor, Physiology & Pharmacology
Comprehensive Cancer Center
Brain Tumor Center of Excellence
Sticht Center on Aging
Center for Comparative Medicine Research
Institute for Regenerative Medicine
Translational Science Institute

Research Interests

cognition/learning, cross(mult/tnslat/inter)discip, drugs/therapeutic agents pharm, engineering/bioengineering, instrument development, model development, neurosciences/behavior, sleep research, substance abuse

Contact Information

Academic: 336-716-8540 | Department: 336-716-8540

Email: sdeadwyl@wakehealth.edu

Recent Publications

Opris I, Fuqua JL, Gerhardt GA, Hampson RE, Deadwyler SA. Prefrontal cortical recordings with biomorphic MEAs reveal complex columnar-laminar microcircuits for BCI/BMI implementation. J Neurosci Methods. 2015;244():104-113.

Fetterhoff D, Opris I, Simpson SL, Deadwyler SA, Hampson RE, Kraft RA. Multifractal analysis of information processing in hippocampal neural ensembles during working memory under Delta(9)-tetrahydrocannabinol administration. J Neurosci Methods. 2015;244():136-153.

Song D, Chan RH, Robinson BS, Marmarelis VZ, Opris I, Hampson RE, Deadwyler SA, Berger TW. Identification of functional synaptic plasticity from spiking activities using nonlinear dynamical modeling. J Neurosci Methods. 2015;244():123-135.

Sandler RA, Deadwyler SA, Hampson RE, Song D, Berger TW, Marmarelis VZ. System identification of point-process neural systems using Probability Based Volterra kernels. J Neurosci Methods. 2015;240():179-192.

Hanbury DB, Robbins ME [deceased], Bourland JD, Wheeler KT, Peiffer AM, Mitchell EL, Daunais JB, Deadwyler SA, Cline JM. Pathology of fractionated whole-brain irradiation in rhesus monkeys (Macaca mulatta). Radiat Res. 2015;183(3):367-374.

Opris I, Gerhardt GA, Hampson RE, Deadwyler SA. Disruption of columnar and laminar cognitive processing in primate prefrontal cortex following cocaine exposure. Front Syst Neurosci. 2015;9():79.

Santos L, Opris I, Hampson R, Godwin DW, Gerhardt G, Deadwyler S. Functional dynamics of primate cortico-striatal networks during volitional movements. Front Syst Neurosci. 2014;8():27.

Marmarelis VZ, Shin DC, Song D, Hampson RE, Deadwyler SA, Berger TW. On parsing the neural code in the prefrontal cortex of primates using principal dynamic modes. J Comput Neurosci. 2014;36(3):321-337.

Song D, Harway M, Marmarelis VZ, Hampson RE, Deadwyler SA, Berger TW. Extraction and restoration of hippocampal spatial memories with non-linear dynamical modeling. Front Syst Neurosci. 2014;8():97.

Deadwyler SA, Berger TW, Opris I, Song D, Hampson RE. Neurons and networks organizing and sequencing memories. Brain Res. 2014;():.

Porrino LJ, Hampson RE, Opris I, Deadwyler SA. Acute cocaine induced deficits in cognitive performance in rhesus macaque monkeys treated with baclofen. Psychopharmacology (Berl). 2013;225(1):105-114.

McQuail JA, Davis KN, Miller F, Hampson RE, Deadwyler SA, Howlett AC, Nicolle MM. Hippocampal G alpha q/11 but not G alpha o-coupled receptors are altered in aging. Neuropharmacology. 2013;70():63-73.

Opris I, Santos L, Gerhardt GA, Song D, Berger TW, Hampson RE, Deadwyler SA. Prefrontal cortical microcircuits bind perception to executive control. Sci Rep. 2013;3():2285.

Song D, Wang H, Tu CY, Marmarelis VZ, Hampson RE, Deadwyler SA, Berger TW. Identification of sparse neural functional connectivity using penalized likelihood estimation and basis functions. J Comput Neurosci. 2013;35(3):335-357.

Hampson RE, Song D, Opris I, Santos LM, Shin DC, Gerhardt GA, Marmarelis VZ, Berger TW, Deadwyler SA. Facilitation of memory encoding in primate hippocampus by a neuroprosthesis that promotes task-specific neural firing. J Neural Eng. 2013;10(6):066013.

Deadwyler SA, Berger TW, Sweatt AJ, Song D, Chan RH, Opris I, Gerhardt GA, Marmarelis VZ, Hampson RE. Donor/recipient enhancement of memory in rat hippocampus. Front Syst Neurosci. 2013;7():120.

Linville C, Mintz A, Hampson R, Deadwyler S, Peiffer A. Changes in FDG-PET uptake during a delayed match to samplememory task [abstract]. Neuro Oncol. 2013;15(Suppl 3):95.

Santos L, Opris I, Fuqua J, Hampson RE, Deadwyler SA. A novel tetrode microdrive for simultaneous multi-neuron recording from different regions of primate brain. J Neurosci Methods. 2012;205(2):368-374.

Berger TW, Song D, Chan RHM, Marmarelis VZ, LaCoss J, Wills J, Hampson RE, Deadwyler SA, Granacki JJ. A hippocampal cognitive prosthesis: multi-input, multi-output nonlinear modeling and VLSI implementation. IEEE Trans Neural Syst Rehabil Eng. 2012;20(2):198-211.

Hampson RE, Song D, Chan RHM, Sweatt AJ, Riley MR, Gerhardt GA, Shin DC, Marmarelis VZ, Berger TW, Deadwyler SA. A nonlinear model for hippocampal cognitive prosthesis: memory facilitation by hippocampal ensemble stimulation. IEEE Trans Neural Syst Rehabil Eng. 2012;20(2):184-197.

Hampson RE, Song D, Chan RHM, Sweatt AJ, Riley MR, Goonawardena AV [sic] [Goonawardane AV], Marmarelis VZ, Gerhardt GA, Berger TW, Deadwyler SA. Closing the loop for memory prosthesis: detecting the role of hippocampal neural ensembles using nonlinear models. IEEE Trans Neural Syst Rehabil Eng. 2012;20(4):510-525.

Hampson RE, Gerhardt GA, Marmarelis V, Song D, Opris I, Santos L, Berger TW, Deadwyler SA. Facilitation and restoration of cognitive function in primate prefrontal cortex by a neuroprosthesis that utilizes minicolumn-specific neural firing. J Neural Eng. 2012;9(5):056012.

Berger T, Song D, Chan R, Shin D, Marmarelis V, Hampson R, Sweatt A, Heck C, Liu C, Wills J, Lacoss J, Granacki J, Gerhardt G, Deadwyler S. Role of the hippocampus in memory formation: restorative encoding memory integration neural device as a cognitive neural prosthesis. IEEE Pulse. 2012;3(5):17-22.

Opris I, Fuqua JL, Huettl PF, Gerhardt GA, Berger TW, Hampson RE, Deadwyler SA. Closing the loop in primate prefrontal cortex: inter-laminar processing. Front Neural Circuits. 2012;6():88.

Opris I, Hampson RE, Gerhardt GA, Berger TW, Deadwyler SA. Columnar processing in primate pFC: evidence for executive control microcircuits. J Cogn Neurosci. 2012;24(12):2334-2347.

Linville C, Hampson R, Deadwyler S, Peiffer A. Exploring late effects of brain irradiation with a delayed match to sample paradigm [abstract]. Neuro Oncol. 2012;14(Suppl 6):62.

Marmarelis VZ, Shin DC, Hampson RE, Deadwyler SA, Song D, Berger TW. Design of optimal stimulation patterns for neuronal ensembles based on Volterra-type hierarchical modeling. J Neural Eng. 2012;9(6):066003.

Taghva A, Song D, Hampson RE, Deadwyler SA, Berger TW. Determination of relevant neuron-neuron connections for neural prosthetics using time-delayed mutual information: tutorial and preliminary results. World Neurosurg. 2012;78(6):618-630.

Hampson RE, Miller F, Palchik G, Deadwyler SA. Cannabinoid receptor activation modifies NMDA receptor mediated release of intracellular calcium: implications for endocannabinoid control of hippocampal neural plasticity. Neuropharmacology. 2011;60(6):944-952.

Hampson RE, Porrino LJ, Opris I, Stanford T, Deadwyler SA. Effects of cocaine rewards on neural representations of cognitive demand in nonhuman primates. Psychopharmacology (Berl). 2011;213(1):105-118.

Opris I, Hampson RE, Stanford TR, Gerhardt GA, Deadwyler SA. Neural activity in frontal cortical cell layers: evidence for columnar sensorimotor processing. J Cogn Neurosci. 2011;23(6):1507-1521.

Hampson RE, Simeral JD, Berger TW, Song D, Chan RHM, Marmarelis VZ, Deadwyler SA. Cognitively relevant recoding in hippocampus: beneficial feedback of ensemble codes in a closed loop paradigm In: Vertes RP, Stackman RW, eds. Electrophysiological recording techniques. Totowa (NJ): Humana Press;2011: 215-240.

Robbins ME, Bourland JD, Cline JM, Wheeler KT, Deadwyler SA. A model for assessing cognitive impairment after fractionated whole-brain irradiation in nonhuman primates. Radiat Res. 2011;175(4):519-525.

Hampson RE, Sweatt AJ, Goonawardena AV [sic] [Goonawardane AV], Song D, Chan RHM, Marmarelis VZ, Berger TW, Deadwyler SA. Memory encoding in hippocampal ensembles is negatively influenced by cannabinoid CB1 receptors. Behav Pharmacol. 2011;22(4):335-346.

Berger TW, Hampson RE, Song D, Goonawardena A [sic] [Goonawardane A], Marmarelis VZ, Deadwyler SA. A cortical neural prosthesis for restoring and enhancing memory. J Neural Eng. 2011;8(4):046017.

Hampson RE, Porrino LJ, Opris I, Stanford TE, Deadwyler SA. Effects of cocaine on neural substrates of cognitive demand in nonhuman primates [abstract]. Behav Pharmacol. 2011;22(Suppl A):e12.

Chan RH, Song D, Goonawardena AV [sic] [Goonawardane AV], Bough S, Sesay J, Hampson RE, Deadwyler SA, Berger TW. Tracking the changes of hippocampal population nonlinear dynamics in rats learning a memory-dependent task. Conf Proc IEEE Eng Med Biol Soc. 2011;2011():3326-3329.

Song D, Chan RH, Marmarelis VZ, Hampson RE, Deadwyler SA, Berger TW. Estimation and statistical validation of event-invariant nonlinear dynamic models of hippocampal CA3-CA1 population activities. Conf Proc IEEE Eng Med Biol Soc. 2011;2011():3330-3333.

Hampson RE, Marmaralis V, Shin DC, Gerhardt GA, Song D, Chan RH, Sweatt AJ, Granacki J, Berger TW, Deadwyler SA. Restorative encoding memory integrative neural device: 'REMIND'. Conf Proc IEEE Eng Med Biol Soc. 2011;2011():3338-3341.

Marmarelis VZ, Shin DC, Song D, Hampson RE, Deadwyler SA, Berger TW. Dynamic nonlinear modeling of interactions between neuronal ensembles using principal dynamic modes. Conf Proc IEEE Eng Med Biol Soc. 2011;2011():3334-3337.

Deadwyler SA. Electrophysiological correlates of abused drugs: relation to natural rewards. Ann N Y Acad Sci. 2010;1187(Addiction Reviews 2):140-147.

Hampson RE, Opris I, Deadwyler SA. Neural correlates of fast pupil dilation in nonhuman primates: relation to behavioral performance and cognitive workload. Behav Brain Res. 2010;212(1):1-11.

Hampson RE, Espana RA, Rogers GA, Porrino LJ, Deadwyler SA. Mechanisms underlying cognitive enhancement and reversal of cognitive deficits in nonhuman primates by the ampakine CX717. Psychopharmacology (Berl). 2009;202(1-3):355-369.

Zanos TP, Hampson RE, Deadwyler SE, Berger TW, Marmarelis VZ. Boolean modeling of neural systems with point-process inputs and outputs. Part II: application to the rat hippocampus. Ann Biomed Eng. 2009;37(8):1668-1682.

Hampson RE, Collins V, Deadwyler SA. A wireless recording system that utilizes Bluetooth technology to transmit neural activity in freely moving animals. J Neurosci Methods. 2009;182(2):195-204.

Opris I, Hampson RE, Deadwyler SA. The encoding of cocaine vs. natural rewards in the striatum of nonhuman primates: categories with different activations. Neuroscience. 2009;163(1):40-54.

Song D, Chan RHM, Marmarelis VZ, Hampson RE, Deadwyler SA, Berger TW. Nonlinear modeling of neural population dynamics for hippocampal prostheses. Neural Netw. 2009;22(9):1340-1351.

Hampson RE, Deadwyler SA. Neural population recording in behaving animals: constituents of a neural code for behavioral decisions In: Holscher C, Munk M, eds. Information processing by neuronal populations. New York: Cambridge University Press;2009: 74-94.

Song D, Chan RH, Marmarelis VZ, Hampson RE, Deadwyler SA, Berger TW. Sparse generalized Laguerre-Volterra model of neural population dynamics. Conf Proc IEEE Eng Med Biol Soc. 2009;2009():4555-4558.

Deadwyler SA, Hampson RE. Endocannabinoids modulate encoding of sequential memory in the rat hippocampus. Psychopharmacology (Berl). 2008;198(4):577-586.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Quick Reference

Request an Appointment
New Patients

336-716-WAKE
888-716-WAKE

Existing patients may contact the clinic directly.
Find a Doctor Ways to Give
USNWR 2015-2016Magnet Hospital RecognitionConsumer Choice2014 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.