Profile

Samuel A. Deadwyler, Ph.D.Wake Forest School of Medicine

Samuel A. Deadwyler, Ph.D.

Professor,

Contact Information

Academic: 336-716-8540 | Department: 336-716-8540

Email: sdeadwyl@wakehealth.edu

Education & Training

  • B.A., San Diego State Univ, 1965
  • Ph.D., SUNY-Stony Brook, 1970

Memberships

  • Am Assn Of Advancement Of Scie
  • Society for Neuroscience
Samuel A. Deadwyler, Ph.D.

Samuel A. Deadwyler, Ph.D.

Professor, Physiology & Pharmacology

Research Interests

Hippocampus; Neurons; Memory; Action Potentials; Rats
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Contact Information

Academic: 336-716-8540 | Department: 336-716-8540

Email: sdeadwyl@wakehealth.edu

Recent Publications

Prefrontal cortical recordings with biomorphic MEAs reveal complex columnar-laminar microcircuits for BCI/BMI implementation. Opris I, Fuqua JL, Gerhardt GA, Hampson RE, Deadwyler SA.. J Neurosci Methods. 2015;244():104-113.

Multifractal analysis of information processing in hippocampal neural ensembles during working memory under Delta(9)-tetrahydrocannabinol administration. Fetterhoff D, Opris I, Simpson SL, Deadwyler SA, Hampson RE, Kraft RA.. J Neurosci Methods. 2015;244():136-153.

Identification of functional synaptic plasticity from spiking activities using nonlinear dynamical modeling. Song D, Chan RH, Robinson BS, Marmarelis VZ, Opris I, Hampson RE, Deadwyler SA, Berger TW.. J Neurosci Methods. 2015;244():123-135.

System identification of point-process neural systems using Probability Based Volterra kernels. Sandler RA, Deadwyler SA, Hampson RE, Song D, Berger TW, Marmarelis VZ.. J Neurosci Methods. 2015;240():179-192.

Neurons and networks organizing and sequencing memories. Deadwyler SA, Berger TW, Opris I, Song D, Hampson RE.. Brain Res. 2015;1621():335-344.

Pathology of fractionated whole-brain irradiation in rhesus monkeys (Macaca mulatta). Hanbury DB, Robbins ME [deceased], Bourland JD, Wheeler KT, Peiffer AM, Mitchell EL, Daunais JB, Deadwyler SA, Cline JM.. Radiat Res. 2015;183(3):367-374.

Disruption of columnar and laminar cognitive processing in primate prefrontal cortex following cocaine exposure. Opris I, Gerhardt GA, Hampson RE, Deadwyler SA.. Front Syst Neurosci. 2015;9():79.

Distinguishing cognitive state with multifractal complexity of hippocampal interspike interval sequences. Fetterhoff D, Kraft RA, Sandler RA, Opris I, Sexton CA, Marmarelis VZ, Hampson RE, Deadwyler SA.. Front Syst Neurosci. 2015;9():130.

Distributed encoding of spatial and object categories in primate hippocampal microcircuits. Opris I, Santos LM, Gerhardt GA, Song D, Berger TW, Hampson RE, Deadwyler SA.. Front Neurosci. 2015;9():317.

Hippocampal closed-loop modeling and implications for seizure stimulation design. Sandler RA, Song D, Hampson RE, Deadwyler SA, Berger TW, Marmarelis VZ.. J Neural Eng. 2015;12(5):056017.

Functional dynamics of primate cortico-striatal networks during volitional movements. Santos L, Opris I, Hampson R, Godwin DW, Gerhardt G, Deadwyler S.. Front Syst Neurosci. 2014;8():27.

On parsing the neural code in the prefrontal cortex of primates using principal dynamic modes. Marmarelis VZ, Shin DC, Song D, Hampson RE, Deadwyler SA, Berger TW.. J Comput Neurosci. 2014;36(3):321-337.

Extraction and restoration of hippocampal spatial memories with non-linear dynamical modeling. Song D, Harway M, Marmarelis VZ, Hampson RE, Deadwyler SA, Berger TW.. Front Syst Neurosci. 2014;8():97.

Acute cocaine induced deficits in cognitive performance in rhesus macaque monkeys treated with baclofen. Porrino LJ, Hampson RE, Opris I, Deadwyler SA.. Psychopharmacology (Berl). 2013;225(1):105-114.

Hippocampal G alpha q/11 but not G alpha o-coupled receptors are altered in aging. McQuail JA, Davis KN, Miller F, Hampson RE, Deadwyler SA, Howlett AC, Nicolle MM.. Neuropharmacology. 2013;70():63-73.

Prefrontal cortical microcircuits bind perception to executive control. Opris I, Santos L, Gerhardt GA, Song D, Berger TW, Hampson RE, Deadwyler SA.. Sci Rep. 2013;3():2285.

Identification of sparse neural functional connectivity using penalized likelihood estimation and basis functions. Song D, Wang H, Tu CY, Marmarelis VZ, Hampson RE, Deadwyler SA, Berger TW.. J Comput Neurosci. 2013;35(3):335-357.

Facilitation of memory encoding in primate hippocampus by a neuroprosthesis that promotes task-specific neural firing. Hampson RE, Song D, Opris I, Santos LM, Shin DC, Gerhardt GA, Marmarelis VZ, Berger TW, Deadwyler SA.. J Neural Eng. 2013;10(6):066013.

Donor/recipient enhancement of memory in rat hippocampus. Deadwyler SA, Berger TW, Sweatt AJ, Song D, Chan RH, Opris I, Gerhardt GA, Marmarelis VZ, Hampson RE.. Front Syst Neurosci. 2013;7():120.

Changes in FDG-PET uptake during a delayed match to samplememory task [abstract]. Linville C, Mintz A, Hampson R, Deadwyler S, Peiffer A.. Neuro Oncol. 2013;15(Suppl 3):95.

A novel tetrode microdrive for simultaneous multi-neuron recording from different regions of primate brain. Santos L, Opris I, Fuqua J, Hampson RE, Deadwyler SA.. J Neurosci Methods. 2012;205(2):368-374.

A hippocampal cognitive prosthesis: multi-input, multi-output nonlinear modeling and VLSI implementation. Berger TW, Song D, Chan RHM, Marmarelis VZ, LaCoss J, Wills J, Hampson RE, Deadwyler SA, Granacki JJ.. IEEE Trans Neural Syst Rehabil Eng. 2012;20(2):198-211.

A nonlinear model for hippocampal cognitive prosthesis: memory facilitation by hippocampal ensemble stimulation. Hampson RE, Song D, Chan RHM, Sweatt AJ, Riley MR, Gerhardt GA, Shin DC, Marmarelis VZ, Berger TW, Deadwyler SA.. IEEE Trans Neural Syst Rehabil Eng. 2012;20(2):184-197.

Closing the loop for memory prosthesis: detecting the role of hippocampal neural ensembles using nonlinear models. Hampson RE, Song D, Chan RHM, Sweatt AJ, Riley MR, Goonawardena AV [sic] [Goonawardane AV], Marmarelis VZ, Gerhardt GA, Berger TW, Deadwyler SA.. IEEE Trans Neural Syst Rehabil Eng. 2012;20(4):510-525.

Facilitation and restoration of cognitive function in primate prefrontal cortex by a neuroprosthesis that utilizes minicolumn-specific neural firing. Hampson RE, Gerhardt GA, Marmarelis V, Song D, Opris I, Santos L, Berger TW, Deadwyler SA.. J Neural Eng. 2012;9(5):056012.

Role of the hippocampus in memory formation: restorative encoding memory integration neural device as a cognitive neural prosthesis. Berger T, Song D, Chan R, Shin D, Marmarelis V, Hampson R, Sweatt A, Heck C, Liu C, Wills J, Lacoss J, Granacki J, Gerhardt G, Deadwyler S.. IEEE Pulse. 2012;3(5):17-22.

Closing the loop in primate prefrontal cortex: inter-laminar processing. Opris I, Fuqua JL, Huettl PF, Gerhardt GA, Berger TW, Hampson RE, Deadwyler SA.. Front Neural Circuits. 2012;6():88.

Columnar processing in primate pFC: evidence for executive control microcircuits. Opris I, Hampson RE, Gerhardt GA, Berger TW, Deadwyler SA.. J Cogn Neurosci. 2012;24(12):2334-2347.

Exploring late effects of brain irradiation with a delayed match to sample paradigm [abstract]. Linville C, Hampson R, Deadwyler S, Peiffer A.. Neuro Oncol. 2012;14(Suppl 6):62.

Design of optimal stimulation patterns for neuronal ensembles based on Volterra-type hierarchical modeling. Marmarelis VZ, Shin DC, Hampson RE, Deadwyler SA, Song D, Berger TW.. J Neural Eng. 2012;9(6):066003.

Determination of relevant neuron-neuron connections for neural prosthetics using time-delayed mutual information: tutorial and preliminary results. Taghva A, Song D, Hampson RE, Deadwyler SA, Berger TW.. World Neurosurg. 2012;78(6):618-630.

Cannabinoid receptor activation modifies NMDA receptor mediated release of intracellular calcium: implications for endocannabinoid control of hippocampal neural plasticity. Hampson RE, Miller F, Palchik G, Deadwyler SA.. Neuropharmacology. 2011;60(6):944-952.

Effects of cocaine rewards on neural representations of cognitive demand in nonhuman primates. Hampson RE, Porrino LJ, Opris I, Stanford T, Deadwyler SA.. Psychopharmacology (Berl). 2011;213(1):105-118.

Neural activity in frontal cortical cell layers: evidence for columnar sensorimotor processing. Opris I, Hampson RE, Stanford TR, Gerhardt GA, Deadwyler SA.. J Cogn Neurosci. 2011;23(6):1507-1521.

Cognitively relevant recoding in hippocampus: beneficial feedback of ensemble codes in a closed loop paradigm. Hampson RE, Simeral JD, Berger TW, Song D, Chan RHM, Marmarelis VZ, Deadwyler SA. In: Vertes RP, Stackman RW, eds. Electrophysiological recording techniques. Totowa (NJ): Humana Press;2011: 215-240.

A model for assessing cognitive impairment after fractionated whole-brain irradiation in nonhuman primates. Robbins ME, Bourland JD, Cline JM, Wheeler KT, Deadwyler SA.. Radiat Res. 2011;175(4):519-525.

Memory encoding in hippocampal ensembles is negatively influenced by cannabinoid CB1 receptors. Hampson RE, Sweatt AJ, Goonawardena AV [sic] [Goonawardane AV], Song D, Chan RHM, Marmarelis VZ, Berger TW, Deadwyler SA.. Behav Pharmacol. 2011;22(4):335-346.

A cortical neural prosthesis for restoring and enhancing memory. Berger TW, Hampson RE, Song D, Goonawardena A [sic] [Goonawardane A], Marmarelis VZ, Deadwyler SA.. J Neural Eng. 2011;8(4):046017.

Effects of cocaine on neural substrates of cognitive demand in nonhuman primates [abstract]. Hampson RE, Porrino LJ, Opris I, Stanford TE, Deadwyler SA.. Behav Pharmacol. 2011;22(Suppl A):e12.

Tracking the changes of hippocampal population nonlinear dynamics in rats learning a memory-dependent task. Chan RH, Song D, Goonawardena AV [sic] [Goonawardane AV], Bough S, Sesay J, Hampson RE, Deadwyler SA, Berger TW.. Conf Proc IEEE Eng Med Biol Soc. 2011;2011():3326-3329.

Estimation and statistical validation of event-invariant nonlinear dynamic models of hippocampal CA3-CA1 population activities. Song D, Chan RH, Marmarelis VZ, Hampson RE, Deadwyler SA, Berger TW.. Conf Proc IEEE Eng Med Biol Soc. 2011;2011():3330-3333.

Restorative encoding memory integrative neural device: 'REMIND'. Hampson RE, Marmaralis V, Shin DC, Gerhardt GA, Song D, Chan RH, Sweatt AJ, Granacki J, Berger TW, Deadwyler SA.. Conf Proc IEEE Eng Med Biol Soc. 2011;2011():3338-3341.

Dynamic nonlinear modeling of interactions between neuronal ensembles using principal dynamic modes. Marmarelis VZ, Shin DC, Song D, Hampson RE, Deadwyler SA, Berger TW.. Conf Proc IEEE Eng Med Biol Soc. 2011;2011():3334-3337.

Electrophysiological correlates of abused drugs: relation to natural rewards. Deadwyler SA.. Ann N Y Acad Sci. 2010;1187(Addiction Reviews 2):140-147.

Neural correlates of fast pupil dilation in nonhuman primates: relation to behavioral performance and cognitive workload. Hampson RE, Opris I, Deadwyler SA.. Behav Brain Res. 2010;212(1):1-11.

Mechanisms underlying cognitive enhancement and reversal of cognitive deficits in nonhuman primates by the ampakine CX717. Hampson RE, Espana RA, Rogers GA, Porrino LJ, Deadwyler SA.. Psychopharmacology (Berl). 2009;202(1-3):355-369.

Boolean modeling of neural systems with point-process inputs and outputs. Part II: application to the rat hippocampus. Zanos TP, Hampson RE, Deadwyler SE, Berger TW, Marmarelis VZ.. Ann Biomed Eng. 2009;37(8):1668-1682.

A wireless recording system that utilizes Bluetooth technology to transmit neural activity in freely moving animals. Hampson RE, Collins V, Deadwyler SA.. J Neurosci Methods. 2009;182(2):195-204.

The encoding of cocaine vs. natural rewards in the striatum of nonhuman primates: categories with different activations. Opris I, Hampson RE, Deadwyler SA.. Neuroscience. 2009;163(1):40-54.

Nonlinear modeling of neural population dynamics for hippocampal prostheses. Song D, Chan RHM, Marmarelis VZ, Hampson RE, Deadwyler SA, Berger TW.. Neural Netw. 2009;22(9):1340-1351.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Samuel A. Deadwyler, Ph.D.

Samuel A. Deadwyler, Ph.D.

Professor, Physiology & Pharmacology

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