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Osvaldo Delbono, M.D., Ph.D.Wake Forest School of Medicine

Osvaldo Delbono, M.D., Ph.D.


Contact Information

Academic: 336-716-8590 | Department: 336-716-9802

Education & Training

  • M.D., Univ Buenos Aires Faculty of Med-Argentina, 1978
  • Ph.D., Univ Buenos Aires Faculty of Med-Argentina, 1986
  • Fellowship, Research Foundation/Grant, 1989
  • Fellowship, Baylor College of Medicine, 1992


  • Society for Neuroscience
  • Biophysics Society
  • Gerontological Assn of America
Osvaldo Delbono, M.D., Ph.D.

Osvaldo Delbono, M.D., Ph.D.

Professor, Gerontology and Geriatric Medicine
Comprehensive Cancer Center

Research Interests

Muscle, Skeletal; Aging; Calcium; Muscle Fibers, Skeletal; Calcium Channels, L-Type
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Contact Information

Academic: 336-716-8590 | Department: 336-716-9802

Recent Publications

Novel peripherally derived neural-like stem cells as therapeutic carriers for treating glioblastomas. Birbrair A, Sattiraju A, Zhu D, Zulato G, Batista I, Nguyen VT, Messi ML, Solingapuram Sai KK, Marini FC, Delbono O, Mintz A.. Stem Cells Transl Med. 2017;6(2):471-481.

Resistance training enhances skeletal muscle innervation without modifying the number of satellite cells or their myofiber association in obese older adults. Messi ML, Li T, Wang ZM, Marsh AP, Nicklas B, Delbono O.. J Gerontol A Biol Sci Med Sci. 2016;71(10):1273-1280.

Intramyocellular lipid and impaired myofiber contraction in normal weight and obese older adults. Choi SJ, Files DC, Zhang T, Wang ZM, Messi ML, Gregory H, Stone J, Lyles MF, Dhar S, Marsh AP, Nicklas BJ, Delbono O.. J Gerontol A Biol Sci Med Sci. 2016;71(4):557-564.

Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice. Zhang T, Pereyra AS, Wang ZM, Birbrair A, Reisz JA, Files DC, Purcell L, Feng X, Messi ML, Feng H, Chalovich J, Jin JP, Furdui C, Delbono O.. Aging Cell. 2016;15(3):488-498.

Magnetofection enhances adenoviral vector-based gene delivery in skeletal muscle cells. Pereyra AS, Mykhaylyk O, Lockhart EF, Taylor JR, Delbono O, Goya RG, Plank C, Herenu CB.. J Nanomed Nanotechnol. 2016;7(2):.

Lung injury-induced skeletal muscle wasting in aged mice is linked to alterations in long chain fatty acid metabolism. Files DC, Ilaiwy A, Parry TL, Gibbs KW, Liu C, Bain JR, Delbono O, Muehlbauer MJ, Willis, MS.. Metabolomics. 2016;12(8):134.

BDA-410 treatment reduces body weight and fat content by enhancing lipolysis in sedentary senescent mice. Pereyra AS, Wang ZM, Messi ML, Zhang T, Wu H, Register TC, Forbes E, Devarie-Baez NO, Files DC, Abba MC, Furdui C, Delbono O.. J Gerontol A Biol Sci Med Sci. 2016;():.

Sympathetic muscle innervation regulates autophagy and the neuromuscular junction with aging [abstract]. Rodrigues A, Wang Z, Messi M, Zhang T, Delbono O.. Gerontologist. 2016;56(Suppl 3):184.

Cardiac troponin T and fast skeletal muscle denervation in older adults [abstract]. Xu Z, Feng X, Dong J, Kritchevsky S, Delbono O, Zhang T.. Gerontologist. 2016;56(Suppl 3):350.

Pericytes at the intersection between tissue regeneration and pathology. Birbrair A, Zhang T, Wang ZM, Messi ML, Mintz A, Delbono O.. Clin Sci (Lond). 2015;128(2):81-93.

Improved knee extensor strength with resistance training associates with muscle specific miRNAs in older adults. Zhang T, Birbrair A, Wang ZM, Messi ML, Marsh AP, Leng I, Nicklas BJ, Delbono O.. Exp Gerontol. 2015;62():7-13.

Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting. Files DC, Liu C, Pereyra A, Wang ZM, Aggarwal NR, D'Alessio FR, Garibaldi BT, Mock JR, Singer BD, Feng X, Yammani RR, Zhang T, Lee AL, Philpott S, Lussier S, Purcell L, Chou J, Seeds M, King LS, Morris PE, Delbono O.. Sci Transl Med. 2015;7(278):278ra32.

Effects of resistance training with and without caloric restriction on physical function and mobility in overweight and obese older adults: a randomized controlled trial. Nicklas BJ, Chmelo E, Delbono O, Carr JJ, Lyles MF, Marsh AP.. Am J Clin Nutr. 2015;101(5):991-999.

Raptor ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation-contraction coupling supramolecular complex. Lopez RJ, Mosca B, Treves S, Maj M, Bergamelli L, Calderon JC, Bentzinger CF, Romanino K, Hall MN, Ruegg MA, Delbono O, Caputo C, Zorzato F.. Biochem J. 2015;466(1):123-135.

Troponin T3 regulates nuclear localization of the calcium channel Cavbeta1a subunit in skeletal muscle. Zhang T, Taylor J, Jiang Y, Pereyra AS, Messi ML, Wang ZM, Herenu C, Delbono O.. Exp Cell Res. 2015;336(2):276-286.

The posterior cricoarytenoid muscle is spared from MuRF1-mediated muscle atrophy in mice with acute lung injury. Files DC, Xiao K, Zhang T, Liu C, Qian J, Zhao W, Morris PE, Delbono O, Feng X.. PLoS One. 2014;9(1):e87587.

Human slow troponin T (TNNT1) Pre-mRNA alternative splicing is an indicator of skeletal muscle response to resistance exercise in older adults. Zhang T, Choi SJ, Wang ZM, Birbrair A, Messi ML, Jin JP, Marsh AP, Nicklas B, Delbono O.. J Gerontol A Biol Sci Med Sci. 2014;69(12):1437-1447.

Type-2 pericytes participate in normal and tumoral angiogenesis. Birbrair A, Zhang T, Wang ZM, Messi ML, Olson JD, Mintz A, Delbono O.. Am J Physiol Cell Physiol. 2014;307(1):C25-C38.

The CaVbeta1A subunit regulates gene expression and suppresses myogenin in muscle progenitor cells. Taylor J, Pereyra A, Zhang T, Messi ML, Wang ZM, Herenu C, Kuan PF, Delbono O.. J Cell Biol. 2014;205(6):829-846.

Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle. Birbrair A, Zhang T, Wang ZM, Messi ML, Mintz A, Delbono O.. Front Aging Neurosci. 2014;6():245.

Skeletal muscle ultrasound as a tool to assess muscle function [abstract]. Dhar S, Nicklas B, Lyles M, Morris P, Delbono O, Files DC.. Crit Care Med. 2014;42(12 Suppl 1):A1528.

Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner. Birbrair A, Zhang T, Files DC, Mannava S, Smith T, Wang ZM, Messi ML, Mintz A, Delbono O.. Stem Cell Res Ther. 2014;5(6):122.

Therapeutic potential of a newly discovered neural like stem cell [abstract]. Sattiraju A, Birbrair A, Zhu D, Batista I, Delbono O, Mintz A.. Neuro Oncol. 2014;16(Suppl 5):v203.

Skeletal muscle neural progenitor cells exhibit properties of NG2-glia. Birbrair A, Zhang T, Wang ZM, Messi ML, Enikolopov GN, Mintz A, Delbono O.. Exp Cell Res. 2013;319(1):45-63.

Skeletal muscle pericyte subtypes differ in their differentiation potential. Birbrair A, Zhang T, Wang Z-M, Messi ML, Enikolopov GN, Mintz A, Delbono O.. Stem Cell Res. 2013;10(1):67-84.

Troponin T nuclear localization and its role in aging skeletal muscle. Zhang T, Birbrair A, Wang ZM, Taylor J, Messi ML, Delbono O.. Age (Dordr). 2013;35(2):353-370.

Force-generation capacity of single vastus lateralis muscle fibers and physical function decline with age in African green vervet monkeys.. Choi SJ, Shively CA, Register TC, Feng X, Stehle J, High K, Ip E, Kritchevsky SB, Nicklas B, Delbono O.. J Gerontol A Biol Sci Med Sci. 2013;68(3):258-267.

JP-45/JSRP1 variants affect skeletal muscle excitation-contraction coupling by decreasing the sensitivity of the dihydropyridine receptor. Yasuda T, Delbono O, Wang ZM, Messi ML, Girard T, Urwyler A, Treves S, Zorzato F.. Hum Mutat. 2013;34(1):184-190.

Nonmyofilament-associated troponin T3 nuclear and nucleolar localization sequence and leucine zipper domain mediate muscle cell apoptosis. Zhang T, Birbrair A, Delbono O.. Cytoskeleton (Hoboken). 2013;70(3):134-147.

Design and application of fluorescent calcium binding proteins with fast kinetics [abstract]. Zhuo Y, Tang S, Wang ZM, Reddish F, Zhang Y, Pennati A, Solntsev KM, Delbono O, WEber I, Gadda G, Yang JJ.. Biophys J. 2013;104(2 Suppl 1):530A.

Enhanced dihydropyridine receptor calcium channel activity restores muscle strength in JP45/CASQ1 double knockout mice. Mosca B, Delbono O, Laura Messi M, Bergamelli L, Wang ZM, Vukcevic M, Lopez R, Treves S, Nishi M, Takeshima H, Paolini C, Martini M, Rispoli G, Protasi F, Zorzato F.. Nat Commun. 2013;4():1541.

Role of pericytes in skeletal muscle regeneration and fat accumulation. Birbrair A, Zhang T, Wang ZM, Messi ML, Enikolopov GN, Mintz A, Delbono O.. Stem Cells Dev. 2013;22(16):2298-2314.

Type-1 pericytes participate in fibrous tissue deposition in aged skeletal muscle. Birbrair A, Zhang T, Wang ZM, Messi ML, Mintz A, Delbono O.. Am J Physiol Cell Physiol. 2013;305(11):C1098-1113.

A critical role for muscle ring finger-1 in acute lung injury-associated skeletal muscle wasting. Files DC, D'Alessio FR, Johnston LF, Kesari P, Aggarwal NR, Garibaldi BT, Mock JR, Simmers JL, DeGorordo A, Murdoch J, Willis MS, Patterson C, Tankersley CG, Messi ML, Liu C, Delbono O, Furlow JD, Bodine SC, Cohn RD, King LS, Crow MT.. Am J Respir Crit Care Med. 2012;185(8):825-834.

Residual sarcoplasmic reticulum Ca2+ concentration after Ca2+ release in skeletal myofibers from young adult and old mice. Wang Z-M, Tang S, Messi ML, Yang JJ, Delbono O.. Pflugers Arch. 2012;463(4):615-624.

Endogenously determined restriction of food intake overcomes excitation-contraction uncoupling in JP45KO mice with aging. Delbono O, Messi ML, Wang Z-M, Treves S, Mosca B, Bergamelli L, Nishi M, Takeshima H, Shi H, Xue B, Zorzato F.. Exp Gerontol. 2012;47(4):304-316.

Effects of vitamin D supplementation on human skeketal muscle composition and regeneration [abstract]. Houston DK, Messi ML, Birbrair A, Demons J, Kritchevsky SB, Delbono O.. FASEB J. 2012;26(Meeting Abstracts):1021.10.

Myosin heavy chain isoform expression in the Vastus Lateralis muscle of aging African green vervet monkeys. Feng X, Zhang T, Xu Z, Choi SJ, Qian J, Furdui CM, Register TC, Delbono O.. Exp Gerontol. 2012;47(8):601-607.

Sarcopenia should be defined as an age-related condition based on clinical but not cellular features [letter]. Delbono O, Taylor JR.. J Appl Physiol. 2012;113(4):683.

Understanding key assay parameters that affect measurements of trastuzumab-mediated ADCC against Her2 positive breast cancer cells. Kute T, Stehle Jr JR, Ornelles D, Walker N, Delbono O, Vaughn JP.. Oncoimmunology. 2012;1(6):810-821.

Non-classical role of troponin T in skeletal muscle [abstract]. Zhang T, Birbrair A, Wang Z, Taylor J, Messi ML, Delbono O.. Gerontologist. 2012;52(Suppl 1):289.

Commentaries on viewpoint: muscle atrophy is not always sarcopenia. Dardevet D, Savary-Auzeloux I, Remond D, Mosoni L, Marzetti E, Buford TW, Bernabei R, Dionne IJ, Buford TW, Marzetti E, Manini TM, Buehring B, Kirchner E, Calabrese L, Manini TM, Clark BC, Fonseca HM, Delbono O, Taylor JR,.. J Appl Physiol. 2012;113(4):680-684.

Nestin-GFP transgene reveals neural precursor cells in adult skeletal muscle. Birbrair A, Wang Z-M, Messi ML, Enikolopov GN, Delbono O.. PLoS ONE. 2011;6(2):e16816.

Design and application of a class of sensors to monitor Ca2+ dynamics in high Ca2+ concentration cellular compartments. Tang S, Wong H-C, Wang Z-M, Huang Y, Zou J, Zhuo Y, Pennati A, Gadda G, Delbono O, Yang JJ.. Proc Natl Acad Sci U S A. 2011;108(39):16265-70.

Expression and regulation of excitation-contraction coupling proteins in aging skeletal muscle. Delbono O.. Curr Aging Sci. 2011;4(3):248-259.

Myosin--still a good reference for skeletal muscle fibre classification? [editorial comment]. Delbono O.. J Physiol. 2010;588(Pt 1):9.

Sarcoplasmic reticulum Ca2+ depletion in adult skeletal muscle fibres measured with the biosensor D1ER. Jimenez-Moreno R, Wang Z-M, Messi ML, Delbono O.. Pflugers Arch. 2010;459(5):725-735.

Aging of the muscles and joints. Loeser RF Jr, Delbono O. In: Halter JB, Ouslander JG, Tinetti ME, Studenski S, High KP, Asthana S, Hazzard WR, Wollard NF, eds. Hazzard's geriatric medicine and gerontology. 6th ed. New York: McGraw Hill Medical;2009: 1355-1368.

Role of Ca2+, membrane excitability, and Ca2+ stores in failing muscle contraction with aging. Payne AM, Jimenez-Moreno R, Wang Z-M, Messi ML, Delbono O.. Exp Gerontol. 2009;44(4):261-273.

Increased CaVbeta1A expression with aging contributes to skeletal muscle weakness. Taylor JR, Zheng Z, Wang ZM, Payne AM, Messi ML, Delbono O.. Aging Cell. 2009;8(5):584-594.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Osvaldo Delbono, M.D., Ph.D.

Osvaldo Delbono, M.D., Ph.D.

Professor, Gerontology and Geriatric Medicine
Comprehensive Cancer Center

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