Osvaldo Delbono, M.D., Ph.D.Wake Forest School of Medicine

Osvaldo Delbono, M.D., Ph.D.


Contact Information

Academic: 336-713-8584 | Department: 336-713-8570

Education & Training

  • M.D., Univ Buenos Aires Faculty of Med-Argentina, 1978
  • Ph.D., Univ Buenos Aires Faculty of Med-Argentina, 1986
  • Fellowship, Research Foundation/Grant, 1989
  • Fellowship, Baylor College of Medicine, 1992


  • Biophysics Society
  • Gerontological Assn of America
  • Society for Neuroscience
Osvaldo Delbono, M.D., Ph.D.

Osvaldo Delbono, M.D., Ph.D.

Professor, Gerontology and Geriatric Medicine
Center for Comparative Medicine Research
Hypertension and Vascular Research Center
Sticht Center on Aging

Research Interests

aging, genomics and proteomics, molecular biology/molecular me, neurosciences/behavior, temporary

Contact Information

Academic: 336-713-8584 | Department: 336-713-8570

Recent Publications

Choi SJ, Files DC, Zhang T, Wang ZM, Messi ML, Gregory H, Stone J, Lyles MF, Dhar S, Marsh AP, Nicklas BJ, Delbono O. Intramyocellular lipid and impaired myofiber contraction in normal weight and obese older adults. J Gerontol A Biol Sci Med Sci. 2016;71(4):557-564.

Zhang T, Pereyra AS, Wang ZM, Birbrair A, Reisz JA, Files DC, Purcell L, Feng X, Messi ML, Feng H, Chalovich J, Jin JP, Furdui C, Delbono O. Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice. Aging Cell. 2016;15(3):488-498.

Birbrair A, Zhang T, Wang ZM, Messi ML, Mintz A, Delbono O. Pericytes at the intersection between tissue regeneration and pathology. Clin Sci (Lond). 2015;128(2):81-93.

Zhang T, Birbrair A, Wang ZM, Messi ML, Marsh AP, Leng I, Nicklas BJ, Delbono O. Improved knee extensor strength with resistance training associates with muscle specific miRNAs in older adults. Exp Gerontol. 2015;62():7-13.

Files DC, Liu C, Pereyra A, Wang ZM, Aggarwal NR, D'Alessio FR, Garibaldi BT, Mock JR, Singer BD, Feng X, Yammani RR, Zhang T, Lee AL, Philpott S, Lussier S, Purcell L, Chou J, Seeds M, King LS, Morris PE, Delbono O. Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting. Sci Transl Med. 2015;7(278):278ra32.

Nicklas BJ, Chmelo E, Delbono O, Carr JJ, Lyles MF, Marsh AP. Effects of resistance training with and without caloric restriction on physical function and mobility in overweight and obese older adults: a randomized controlled trial. Am J Clin Nutr. 2015;101(5):991-999.

Lopez RJ, Mosca B, Treves S, Maj M, Bergamelli L, Calderon JC, Bentzinger CF, Romanino K, Hall MN, Ruegg MA, Delbono O, Caputo C, Zorzato F. Raptor ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation-contraction coupling supramolecular complex. Biochem J. 2015;466(1):123-135.

Zhang T, Taylor J, Jiang Y, Pereyra AS, Messi ML, Wang ZM, Herenu C, Delbono O. Troponin T3 regulates nuclear localization of the calcium channel Cavbeta1a subunit in skeletal muscle. Exp Cell Res. 2015;336(2):276-286.

Messi ML, Li T, Wang ZM, Marsh AP, Nicklas B, Delbono O. Resistance training enhances skeletal muscle innervation without modifying the number of satellite cells or their myofiber association in obese older adults. J Gerontol A Biol Sci Med Sci. 2015;():.

Files DC, Xiao K, Zhang T, Liu C, Qian J, Zhao W, Morris PE, Delbono O, Feng X. The posterior cricoarytenoid muscle is spared from MuRF1-mediated muscle atrophy in mice with acute lung injury. PLoS One. 2014;9(1):e87587.

Zhang T, Choi SJ, Wang ZM, Birbrair A, Messi ML, Jin JP, Marsh AP, Nicklas B, Delbono O. Human slow troponin T (TNNT1) Pre-mRNA alternative splicing is an indicator of skeletal muscle response to resistance exercise in older adults. J Gerontol A Biol Sci Med Sci. 2014;69(12):1437-1447.

Birbrair A, Zhang T, Wang ZM, Messi ML, Olson JD, Mintz A, Delbono O. Type-2 pericytes participate in normal and tumoral angiogenesis. Am J Physiol Cell Physiol. 2014;307(1):C25-C38.

Taylor J, Pereyra A, Zhang T, Messi ML, Wang ZM, Herenu C, Kuan PF, Delbono O. The CaVbeta1A subunit regulates gene expression and suppresses myogenin in muscle progenitor cells. J Cell Biol. 2014;205(6):829-846.

Birbrair A, Zhang T, Wang ZM, Messi ML, Mintz A, Delbono O. Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle. Front Aging Neurosci. 2014;6():245.

Dhar S, Nicklas B, Lyles M, Morris P, Delbono O, Files DC. Skeletal muscle ultrasound as a tool to assess muscle function [abstract]. Crit Care Med. 2014;42(12 Suppl 1):A1528.

Birbrair A, Zhang T, Files DC, Mannava S, Smith T, Wang ZM, Messi ML, Mintz A, Delbono O. Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner. Stem Cell Res Ther. 2014;5(6):122.

Sattiraju A, Birbrair A, Zhu D, Batista I, Delbono O, Mintz A. Therapeutic potential of a newly discovered neural like stem cell [abstract]. Neuro Oncol. 2014;16(Suppl 5):v203.

Birbrair A, Zhang T, Wang ZM, Messi ML, Enikolopov GN, Mintz A, Delbono O. Skeletal muscle neural progenitor cells exhibit properties of NG2-glia. Exp Cell Res. 2013;319(1):45-63.

Birbrair A, Zhang T, Wang Z-M, Messi ML, Enikolopov GN, Mintz A, Delbono O. Skeletal muscle pericyte subtypes differ in their differentiation potential. Stem Cell Res. 2013;10(1):67-84.

Zhang T, Birbrair A, Wang ZM, Taylor J, Messi ML, Delbono O. Troponin T nuclear localization and its role in aging skeletal muscle. Age (Dordr). 2013;35(2):353-370.

Choi SJ, Shively CA, Register TC, Feng X, Stehle J, High K, Ip E, Kritchevsky SB, Nicklas B, Delbono O. Force-generation capacity of single vastus lateralis muscle fibers and physical function decline with age in African green vervet monkeys.. J Gerontol A Biol Sci Med Sci. 2013;68(3):258-267.

Yasuda T, Delbono O, Wang ZM, Messi ML, Girard T, Urwyler A, Treves S, Zorzato F. JP-45/JSRP1 variants affect skeletal muscle excitation-contraction coupling by decreasing the sensitivity of the dihydropyridine receptor. Hum Mutat. 2013;34(1):184-190.

Zhang T, Birbrair A, Delbono O. Nonmyofilament-associated troponin T3 nuclear and nucleolar localization sequence and leucine zipper domain mediate muscle cell apoptosis. Cytoskeleton (Hoboken). 2013;70(3):134-147.

Zhuo Y, Tang S, Wang ZM, Reddish F, Zhang Y, Pennati A, Solntsev KM, Delbono O, WEber I, Gadda G, Yang JJ. Design and application of fluorescent calcium binding proteins with fast kinetics [abstract]. Biophys J. 2013;104(2 Suppl 1):530A.

Mosca B, Delbono O, Laura Messi M, Bergamelli L, Wang ZM, Vukcevic M, Lopez R, Treves S, Nishi M, Takeshima H, Paolini C, Martini M, Rispoli G, Protasi F, Zorzato F. Enhanced dihydropyridine receptor calcium channel activity restores muscle strength in JP45/CASQ1 double knockout mice. Nat Commun. 2013;4():1541.

Birbrair A, Zhang T, Wang ZM, Messi ML, Enikolopov GN, Mintz A, Delbono O. Role of pericytes in skeletal muscle regeneration and fat accumulation. Stem Cells Dev. 2013;22(16):2298-2314.

Birbrair A, Zhang T, Wang ZM, Messi ML, Mintz A, Delbono O. Type-1 pericytes participate in fibrous tissue deposition in aged skeletal muscle. Am J Physiol Cell Physiol. 2013;305(11):C1098-1113.

Files DC, D'Alessio FR, Johnston LF, Kesari P, Aggarwal NR, Garibaldi BT, Mock JR, Simmers JL, DeGorordo A, Murdoch J, Willis MS, Patterson C, Tankersley CG, Messi ML, Liu C, Delbono O, Furlow JD, Bodine SC, Cohn RD, King LS, Crow MT. A critical role for muscle ring finger-1 in acute lung injury-associated skeletal muscle wasting. Am J Respir Crit Care Med. 2012;185(8):825-834.

Wang Z-M, Tang S, Messi ML, Yang JJ, Delbono O. Residual sarcoplasmic reticulum Ca2+ concentration after Ca2+ release in skeletal myofibers from young adult and old mice. Pflugers Arch. 2012;463(4):615-624.

Delbono O, Messi ML, Wang Z-M, Treves S, Mosca B, Bergamelli L, Nishi M, Takeshima H, Shi H, Xue B, Zorzato F. Endogenously determined restriction of food intake overcomes excitation-contraction uncoupling in JP45KO mice with aging. Exp Gerontol. 2012;47(4):304-316.

Houston DK, Messi ML, Birbrair A, Demons J, Kritchevsky SB, Delbono O. Effects of vitamin D supplementation on human skeketal muscle composition and regeneration [abstract]. FASEB J. 2012;26(Meeting Abstracts):1021.10.

Feng X, Zhang T, Xu Z, Choi SJ, Qian J, Furdui CM, Register TC, Delbono O. Myosin heavy chain isoform expression in the Vastus Lateralis muscle of aging African green vervet monkeys. Exp Gerontol. 2012;47(8):601-607.

Delbono O, Taylor JR. Sarcopenia should be defined as an age-related condition based on clinical but not cellular features [letter]. J Appl Physiol. 2012;113(4):683.

Kute T, Stehle Jr JR, Ornelles D, Walker N, Delbono O, Vaughn JP. Understanding key assay parameters that affect measurements of trastuzumab-mediated ADCC against Her2 positive breast cancer cells. Oncoimmunology. 2012;1(6):810-821.

Zhang T, Birbrair A, Wang Z, Taylor J, Messi ML, Delbono O. Non-classical role of troponin T in skeletal muscle [abstract]. Gerontologist. 2012;52(Suppl 1):289.

Dardevet D, Savary-Auzeloux I, Remond D, Mosoni L, Marzetti E, Buford TW, Bernabei R, Dionne IJ, Buford TW, Marzetti E, Manini TM, Buehring B, Kirchner E, Calabrese L, Manini TM, Clark BC, Fonseca HM, Delbono O, Taylor JR,. Commentaries on viewpoint: muscle atrophy is not always sarcopenia. J Appl Physiol. 2012;113(4):680-684.

Birbrair A, Wang Z-M, Messi ML, Enikolopov GN, Delbono O. Nestin-GFP transgene reveals neural precursor cells in adult skeletal muscle. PLoS ONE. 2011;6(2):e16816.

Tang S, Wong H-C, Wang Z-M, Huang Y, Zou J, Zhuo Y, Pennati A, Gadda G, Delbono O, Yang JJ. Design and application of a class of sensors to monitor Ca2+ dynamics in high Ca2+ concentration cellular compartments. Proc Natl Acad Sci U S A. 2011;108(39):16265-70.

Delbono O. Expression and regulation of excitation-contraction coupling proteins in aging skeletal muscle. Curr Aging Sci. 2011;4(3):248-259.

Delbono O. Myosin--still a good reference for skeletal muscle fibre classification? [editorial comment]. J Physiol. 2010;588(Pt 1):9.

Jimenez-Moreno R, Wang Z-M, Messi ML, Delbono O. Sarcoplasmic reticulum Ca2+ depletion in adult skeletal muscle fibres measured with the biosensor D1ER. Pflugers Arch. 2010;459(5):725-735.

Loeser RF Jr, Delbono O. Aging of the muscles and joints In: Halter JB, Ouslander JG, Tinetti ME, Studenski S, High KP, Asthana S, Hazzard WR, Wollard NF, eds. Hazzard's geriatric medicine and gerontology. 6th ed. New York: McGraw Hill Medical;2009: 1355-1368.

Payne AM, Jimenez-Moreno R, Wang Z-M, Messi ML, Delbono O. Role of Ca2+, membrane excitability, and Ca2+ stores in failing muscle contraction with aging. Exp Gerontol. 2009;44(4):261-273.

Taylor JR, Zheng Z, Wang ZM, Payne AM, Messi ML, Delbono O. Increased CaVbeta1A expression with aging contributes to skeletal muscle weakness. Aging Cell. 2009;8(5):584-594.

Yoshikawa M, Vinsant S, Mansfield CM, Gifondorwa DJ, Pace L, Messi LM [sic] [Messi ML], Caress J, Cartwright M, Delbono O, Oppenheim RW, Milligan CE, et al. Identification of changes in muscle, neuromuscular junctions and spinal cord at early pre-symptomatic stages in the mutant SOD1 mouse model of ALS may provide novel insight for diagnosis and treatment development [abstract]. Soc Neurosci Abstr. 2009;2009(Neuroscience Meeting Planner):.

Zorzato F, Delbono O, Treves S, Nishi M, Takeshima H. Modulation of skeletal muscle excitation-contraction coupling by protein components of the sarcoplasmic reticulum junctional face membrane [abstract]. J Physiol Sci. 2009;59(Suppl 1):42.

Jimenez-Moreno R, Wang Z-M, Gerring RC Delbono O. Sarcoplasmic reticulum Ca2+ release declines in muscle fibers from aging mice. Biophys J. 2008;94(8):3178-3188.

Jimenez-Moreno R, Wang Z-M, Messi ML, Delbono O. Failure to generate action potential in aging muscle fibers under physiological recording conditions [abstract]. Biophys J. 2008;(Suppl):310.

Nicklas BJ, Leng I, Delbono O, Kitzman DW, Marsh AP, Hundley WG, Lyles MF, O'Rourke KS, Annex BH, Kraus WE. Relationship of physical function to vastus lateralis capillary density and metabolic enzyme activity in elderly men and women. Aging Clin Exp Res. 2008;20(4):302-309.

Jimenez-Moreno R, Zheng ZL, Delbono O. Sareoplasmic/endoplasmic reticulum Ca2+ content and release analyzed with the genetically targeted chameleon Ca2+ indicators D1ER and D4ER [abstract]. Biophys J. 2007;(Suppl):255a.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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