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Osvaldo Delbono, M.D., Ph.D.

Osvaldo Delbono, M.D., Ph.D.

Contact Information
Appointment:
336-713-8250
Office:
336-716-9802
Fax:
336-713-8588
Education & Training
  MD Univ Buenos Aires Faculty of Med-Argentina 1978
  PhD Univ Buenos Aires Faculty of Med-Argentina 1986
Fellowship Research Foundation/Grant 1989
  Baylor College of Medicine 1992
Memberships
Society for Neuroscience
Biophysics Society
Gerontological Association of America
Osvaldo Delbono, M.D., Ph.D.

Osvaldo Delbono, M.D., Ph.D.

Contact Information
Appointment:
336-713-8250
Office:
336-716-9802
Fax:
336-713-8588
Research Interests
aging , molecular biology/molecular me
Recent Publications
Birbrair A, Wang Z-M, Messi ML, Enikolopov GN, Delbono O. Nestin-GFP transgene reveals neural precursor cells in adult skeletal muscle. PLoS ONE. 2011; 6(2):e16816.

Tang S, Wong H-C, Wang Z-M, Huang Y, Zou J, Zhuo Y, Pennati A, Gadda G, Delbono O, Yang JJ. Design and application of a class of sensors to monitor Ca2+ dynamics in high Ca2+ concentration cellular compartments. Proc Natl Acad Sci U S A. 2011; 108(39):16265-70.



Jimenez-Moreno R, Wang Z-M, Messi ML, Delbono O. Sarcoplasmic reticulum Ca2+ depletion in adult skeletal muscle fibres measured with the biosensor D1ER. Pflugers Arch. 2010; 459(5):725-735.

Loeser RF Jr, Delbono O. Aging of the muscles and joints. In: Halter JB, Ouslander JG, Tinetti ME, Studenski S, High KP, Asthana S, Hazzard WR, Wollard NF, eds. Hazzard's geriatric medicine and gerontology. 6th ed. New York: McGraw Hill Medical; 2009: 1355-1368.

Payne AM, Jimenez-Moreno R, Wang Z-M, Messi ML, Delbono O. Role of Ca2+, membrane excitability, and Ca2+ stores in failing muscle contraction with aging. Exp Gerontol. 2009; 44(4):261-273.

Taylor JR, Zheng Z, Wang ZM, Payne AM, Messi ML, Delbono O. Increased CaVbeta1A expression with aging contributes to skeletal muscle weakness. Aging Cell. 2009; 8(5):584-594.

Yoshikawa M, Vinsant S, Mansfield CM, Gifondorwa DJ, Pace L, Messi LM [sic] [Messi ML], Caress J, Cartwright M, Delbono O, Oppenheim RW, Milligan CE, et al. Identification of changes in muscle, neuromuscular junctions and spinal cord at early pre-symptomatic stages in the mutant SOD1 mouse model of ALS may provide novel insight for diagnosis and treatment development [abstract]. Soc Neurosci Abstr. 2009; 2009(Neuroscience Meeting Planner):.

Zorzato F, Delbono O, Treves S, Nishi M, Takeshima H. Modulation of skeletal muscle excitation-contraction coupling by protein components of the sarcoplasmic reticulum junctional face membrane [abstract]. J Physiol Sci. 2009; 59(Suppl 1):42.

Jimenez-Moreno R, Wang Z-M, Gerring RC Delbono O. Sarcoplasmic reticulum Ca2+ release declines in muscle fibers from aging mice. Biophys J. 2008; 94(8):3178-3188.

Jimenez-Moreno R, Wang Z-M, Messi ML, Delbono O. Failure to generate action potential in aging muscle fibers under physiological recording conditions [abstract]. Biophys J. 2008; (Suppl):310.

Nicklas BJ, Leng I, Delbono O, Kitzman DW, Marsh AP, Hundley WG, Lyles MF, O'Rourke KS, Annex BH, Kraus WE. Relationship of physical function to vastus lateralis capillary density and metabolic enzyme activity in elderly men and women. Aging Clin Exp Res. 2008; 20(4):302-309.

Jimenez-Moreno R, Zheng ZL, Delbono O. Sareoplasmic/endoplasmic reticulum Ca2+ content and release analyzed with the genetically targeted chameleon Ca2+ indicators D1ER and D4ER [abstract]. Biophys J. 2007; (Suppl):255a.

Payne AM, Messi ML, Zheng ZL, Delbono O. Motor neuron targeting of IGF-1 attenuates age-related external Ca2+-dependent skeletal muscle contraction in senescent mice [abstract]. Biophys J. 2007; (Suppl):310a.

Zheng Z, Wang Z-m, Payne AM, Jimenez-Moreno R, Delbono O. DHPR beta1a subunit expression increases in aging skeletal muscle [abstract]. Biophys J. 2007; (Suppl):311a.

Zorzato F, Xia J, Treves S, Jimenez-Moreno R, Wang Z-M, Payne AM, Messi ML, Briguet A, Schaerer F, Delbono O, et al. Knockout of the gene encoding the sareoplasmic reticuhum protein JP-45 impairs excitation-contraction coupling in skeletal muscle [abstract]. Biophys J. 2007; (Suppl):21a.



Wang ZM, Zheng Z, Messi ML, Delbono O. Muscle fibers from senescent mice retain excitation-contraction coupling properties in culture. In Vitro Cell Dev Biol Anim. 2007; 43(7):222-234.

Delbono O, Xia J, Treves S, Wang Z-M, Jimenez-Moreno R, Payne AM, Messi ML, Briguet A, Schaerer F, Nishi M, et al. Loss of skeletal muscle strength by ablation of the sarcoplasmic reticulum protein JP45. Proc Natl Acad Sci U S A. 2007; 104(50):20108-113.

Moreno RJ, Messi ML, Zheng Z, Wang Z-M, Ye P, D'Ercole JA, Delbono O. Role of sustained overexpression of central nervous system IGF-I in the age-dependent decline of mouse excitation-contraction coupling. J Membr Biol. 2006; 212(3):147-161.
All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Last Updated 5/7/2012
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