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Jingzhong Ding, Ph.D.Wake Forest School of Medicine

Jingzhong Ding, Ph.D.

Associate Professor,
Ctr for Vaccines at Extremes

Contact Information

Academic: 336-713-8570 | Department: 336-713-8570

Education & Training

  • M.D., Bengbu Medical College in China, 1991
  • Ph.D., Sch Hyg & PH;Johns Hopkins U, 2002
Jingzhong Ding, Ph.D.

Jingzhong Ding, Ph.D.

Associate Professor, Gerontology and Geriatric Medicine
Ctr for Vaccines at Extremes
Professor, Epidemiology & Prevention

Research Interests

Adipose Tissue; Pericardium; Calcinosis; Atherosclerosis; Coronary Artery Disease
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Contact Information

Academic: 336-713-8570 | Department: 336-713-8570

Recent Publications

A DNA methylation biomarker of alcohol consumption. Liu C, Marioni RE, Hedman AK, Pfeiffer L, Tsai PC, Reynolds LM, Just AC, Duan Q, Boer CG, Tanaka T, Elks CE, Aslibekyan S, Brody JA, Kuhnel B, Herder C, Almli LM, Zhi D, Wang Y, Huan T, Yao C, Mendelson MM, Joehanes R, Liang L, Love SA,.. Mol Psychiatry. 2018;23(2):422-433.

Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation. Chu AY, Deng X, Fisher VA, Drong A, Zhang Y, Feitosa MF, Liu CT, Weeks O, Choh AC, Duan Q, Dyer TD, Eicher JD, Guo X, Heard-Costa NL, Kacprowski T, Kent JW Jr, Lange LA, Liu X, Lohman K, Lu L, Mahajan A, O'Connell JR, Parihar A, Peralta JM,.. Nat Genet. 2017;49(1):125-130.

Racial differences in circulating levels of the soluble receptor for advanced glycation endproducts in middle-aged and older adults. Brinkley TE, Leng X, Nicklas BJ, Kritchevsky SB, Ding J, Kitzman DW, Hundley WG.. Metabolism. 2017;70():98-106.

Pericardial, but not hepatic, fat by CT is associated with CV outcomes and structure: the Multi-Ethnic Study of Atherosclerosis. Shah RV, Anderson A, Ding J, Budoff M, Rider O, Petersen SE, Jensen MK, Koch M, Allison M, Kawel-Boehm N, Wisocky J, Jerosch-Herold M, Mukamal K, Lima JA, Murthy VL.. JACC Cardiovasc Imaging. 2017;10(9):1016-1027.

1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function. Gorski M, van der Most PJ, Teumer A, Chu AY, Li M, Mijatovic V, Nolte IM, Cocca M, Taliun D, Gomez F, Li Y, Tayo B, Tin A, Feitosa MF, Aspelund T, Attia J, Biffar R, Bochud M, Boerwinkle E, Borecki I, Bottinger EP, Chen MH, Chouraki V, Ciullo M,.. Sci Rep. 2017;7():45040.

Pericardial fat volume and incident atrial fibrillation in the Multi-Ethnic Study of Atherosclerosis and Jackson Heart Study. Heckbert SR, Wiggins KL, Blackshear C, Yang Y, Ding J, Liu J, McKnight B, Alonso A, Austin TR, Benjamin EJ, Curtis LH, Sotoodehnia N, Correa A.. Obesity (Silver Spring). 2017;25(6):1115-1121.

Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis. Liu Y, Reynolds LM, Ding J, Hou L, Lohman K, Young T, Cui W, Huang Z, Grenier C, Wan M, Stunnenberg HG, Siscovick D, Hou L, Psaty BM, Rich SS, Rotter JI, Kaufman JD, Burke GL, Murphy S, Jacobs DR Jr, Post W, Hoeschele I, Bell DA, Herrington D,.. Nat Commun. 2017;8(1):393.

Transcriptome-wide analysis identifies novel associations with blood pressure. Zeller T, Schurmann C, Schramm K, Muller C, Kwon S, Wild PS, Teumer A, Herrington D, Schillert A, Iacoviello L, Kratzer A, Jagodzinski A, Karakas M, Ding J, Neumann JT, Kuulasmaa K, Gieger C, Kacprowski T, Schnabel RB, Roden M, Wahl S, Rotter JI,.. Hypertension. 2017;70(4):743-750.

Bivariate genome-wide association study of depressive symptoms with type 2 diabetes and quantitative glycemic traits. Haljas K, Amare AT, Alizadeh BZ, Hsu YH, Mosley T, Newman A, Murabito J, Tiemeier H, Tanaka T, van Duijn C, Ding J, Llewellyn DJ, Bennett DA, Terracciano A, Launer L, Ladwig KH, Cornelis MC, Teumer A, Grabe H, Kardia SLR, Ware EB, Smith JA,.. Psychosom Med. 2017;():.

GWAS for executive function and processing speed suggests involvement of the CADM2 gene. Ibrahim-Verbaas CA, Bressler J, Debette S, Schuur M, Smith AV, Bis JC, Davies G, Trompet S, Smith JA, Wolf C, Chibnik LB, Liu Y, Vitart V, Kirin M, Petrovic K, Polasek O, Zgaga L, Fawns-Ritchie C, Hoffmann P, Karjalainen J, Lahti J, Llewellyn DJ,.. Mol Psychiatry. 2016;21(2):189-197.

Higher pericardial adiposity is associated with prevalent diabetes: the Coronary Artery Risk Development in Young Adults study. Alman AC, Jacobs DR Jr, Lewis CE, Snell-Bergeon JK, Carnethon MR, Terry JG, Goff DC Jr, Ding J, Carr JJ.. Nutr Metab Cardiovasc Dis. 2016;26(4):326-332.

Diet and adipose tissue distributions: the Multi-Ethnic Study of Atherosclerosis. Shah RV, Murthy VL, Allison MA, Ding J, Budoff M, Frazier-Wood AC, Lima JA, Steffen L, Siscovick D, Tucker KL, Ouyang P, Abbasi SA, Danielson K, Jerosch-Herold M, Mozaffarian D.. Nutr Metab Cardiovasc Dis. 2016;26(3):185-193.

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Pattaro C, Teumer A, Gorski M, Chu AY, Li M, Mijatovic V, Garnaas M, Tin A, Sorice R, Li Y, Taliun D, Olden M, Foster M, Yang Q, Chen MH, Pers TH, Johnson AD, Ko YA, Fuchsberger C, Tayo B, Nalls M, Feitosa MF, Isaacs A, Dehghan A, d'Adamo P, Adeyemo A,.. Nat Commun. 2016;7():10023.

Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies. Demirkan A, Lahti J, Direk N, Viktorin A, Lunetta KL, Terracciano A, Nalls MA, Tanaka T, Hek K, Fornage M, Wellmann J, Cornelis MC, Ollila HM, Yu L, Smith JA, Pilling LC, Isaacs A, Palotie A, Zhuang WV, Zonderman A, Faul JD, Sutin A, Meirelles O,.. Psychol Med. 2016;46(8):1613-1623.

Genome-wide association study for incident myocardial infarction and coronary heart disease in prospective cohort studies: the CHARGE consortium. Dehghan A, Bis JC, White CC, Smith AV, Morrison AC, Cupples LA, Trompet S, Chasman DI, Lumley T, Volker U, Buckley BM, Ding J, Jensen MK, Folsom AR, Kritchevsky SB, Girman CJ, Ford I, Dorr M, Salomaa V, Uitterlinden AG, Eiriksdottir G, Vasan RS,.. PLoS One. 2016;11(3):e0144997.

Pericardial fat and right ventricular morphology: the Multi-Ethnic Study of Atherosclerosis- Right Ventricle Study (MESA-RV). Wenger DS, Kawut SM, Ding J, Bluemke DA, Hough CL, Kronmal RA, Lima JA, Leary PJ.. PLoS One. 2016;11(6):e0157654.

An empirical comparison of joint and stratified frameworks for studying G x E interactions: systolic blood pressure and smoking in the CHARGE Gene-Lifestyle Interactions Working Group. Sung YJ, Winkler TW, Manning AK, Aschard H, Gudnason V, Harris TB, Smith AV, Boerwinkle E, Brown MR, Morrison AC, Fornage M, Lin LA, Richard M, Bartz TM, Psaty BM, Hayward C, Polasek O, Marten J, Rudan I, Feitosa MF, Kraja AT, Province MA,.. Genet Epidemiol. 2016;40(5):404-415.

Epigenetic signatures of cigarette smoking. Joehanes R, Just AC, Marioni RE, Pilling LC, Reynolds LM, Mandaviya PR, Guan W, Xu T, Elks CE, Aslibekyan S, Moreno-Macias H, Smith JA, Brody JA, Dhingra R, Yousefi P, Pankow JS, Kunze S, Shah SH, McRae AF, Lohman K, Sha J, Absher DM,.. Circ Cardiovasc Genet. 2016;9(5):436-447.

Ectopic fat depots and coronary artery calcium in South Asians compared with other racial/ethnic groups. Garg SK, Lin F, Kandula N, Ding J, Carr J, Allison M, Liu K, Herrington D, Vaidya D, Vittinghoff E, Kanaya AM.. J Am Heart Assoc. 2016;5(11):e004257.

Gene-gene interaction analyses for atrial fibrillation. Lin H, Mueller-Nurasyid M, Smith AV, Arking DE, Barnard J, Bartz TM, Lunetta KL, Lohman K, Kleber ME, Lubitz SA, Geelhoed B, Trompet S, Niemeijer MN, Kacprowski T, Chasman DI, Klarin D, Sinner MF, Waldenberger M, Meitinger T, Harris TB, Launer LJ,.. Sci Rep. 2016;6():35371.

Genome-wide association study of kidney function decline in individuals of European descent. Gorski M, Tin A, Garnaas M, McMahon GM, Chu AY, Tayo BO, Pattaro C, Teumer A, Chasman DI, Chalmers J, Hamet P, Tremblay J, Woodward M, Aspelund T, Eiriksdottir G, Gudnason V, Harris TB, Launer LJ, Smith AV, Mitchell BD, O'Connell JR, Shuldiner AR,.. Kidney Int. 2015;87(5):1017-1029.

Relationship of pericardial fat with biomarkers of inflammation and hemostasis, and cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Ong KL, Ding J, McClelland RL, Cheung BM, Criqui MH, Barter PJ, Rye KA, Allison MA.. Atherosclerosis. 2015;239(2):386-392.

Transcriptomic profiles of aging in purified human immune cells. Reynolds LM, Ding J, Taylor JR, Lohman K, Soranzo N, de la Fuente A, Liu TF, Johnson C, Barr RG, Register TC, Donohue KM, Talor MV, Cihakova D, Gu C, Divers J, Siscovick D, Burke G, Post W, Shea S, Jacobs DR Jr, Hoeschele I, McCall CE,.. BMC Genomics. 2015;16(1):333.

Relationship of pericardial fat with lipoprotein distribution: the Multi-Ethnic Study of Atherosclerosis. Ong KL, Ding J, McClelland RL, Cheung BM, Criqui MH, Barter PJ, Rye KA, Allison MA.. Atherosclerosis. 2015;241(2):664-670.

Relation of anthropometric obesity and computed tomography measured nonalcoholic fatty liver disease (from the Multiethnic Study of Atherosclerosis). Tison GH, Blaha MJ, Nasir K, Blumenthal RS, Szklo M, Ding J, Budoff MJ.. Am J Cardiol. 2015;116(4):541-546.

Alterations of a cellular cholesterol metabolism network are a molecular feature of obesity-related type 2 diabetes and cardiovascular disease. Ding J, Reynolds LM, Zeller T, Muller C, Mstat KL, Nicklas BJ, Kritchevsky SB, Huang Z, Fuente A, Soranzo N, Settlage RE, Chuang CC, Howard T, Xu N, Goodarzi MO, Ida Chen YD, Rotter JI, Siscovick DS, Parks JS, Murphy S, Jacobs DR Jr,.. Diabetes. 2015;64(10):3464-3474.

Liver fat, statin use, and incident diabetes: the Multi-Ethnic Study of Atherosclerosis. Shah R, Allison MA, Lima JA, Bluemke DA, Abbasi SA, Ouyang P, Jerosch-Herold M, Ding J, Budoff , Murthy VL.. Atherosclerosis. 2015;242(1):211-217.

DNA methylation of the aryl hydrocarbon receptor repressor associations with cigarette smoking and subclinical atherosclerosis. Reynolds LM, Wan M, Ding J, Taylor JR, Lohman K, Su D, Bennett BD, Porter DK, Gimple R, Pittman GS, Wang X, Howard TD, Siscovick D, Psaty BM, Shea S, Burke GL, Jacobs DR Jr, Rich SS, Hixson JE, Stein JH, Stunnenberg H, Barr RG,.. Circ Cardiovasc Genet. 2015;8(5):707-716.

The sex and race specific relationship between anthropometry and body fat composition determined from computed tomography: evidence from the Multi-Ethnic Study of Atherosclerosis. Mongraw-Chaffin M, Golden SH, Allison MA, Ding J, Ouyang P, Schreiner PJ, Szklo M, Woodward M, Young JH, Anderson CA.. PLoS One. 2015;10(10):e0139559.

Liver steatosis and the risk of albuminuria: the Multi-Ethnic Study of Atherosclerosis. Shah RV, Allison MA, Lima JA, Abbasi SA, Mongraw-Chaffin M, Jerosch-Herold M, Ding J, Budoff MJ, Murthy VL.. J Nephrol. 2015;28(5):577-584.

The transcriptional landscape of age in human peripheral blood. Peters MJ, Joehanes R, Pilling LC, Schurmann C, Conneely KN, Powell J, Reinmaa E, Sutphin GL, Zhernakova A, Schramm K, Wilson YA, Kobes S, Tukiainen T, Ramos YF, Goring HH, Fornage M, Liu Y, Gharib SA, Stranger BE, De Jager PL, Aviv A,.. Nat Commun. 2015;6():8570.

Relationship of pericardial fat with right ventricular structure and function: the Multi-Ethnic Study Of Atherosclerosis- Right Ventricle Study [abstract]. Wenger DS, Ding J, Barr RG, Bluemke DA, Hough CL, Kronmal R, Lima J, Tracy RP, Kawut SM, Leary PJ.. Am J Respir Crit Care Med. 2015;191():A4855.

Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels: a randomized clinical trial. Williamson JD, Launer LJ, Bryan RN, Coker LH, Lazar RM, Gerstein HC, Murray AM, Sullivan MD, Horowitz KR, Ding J, Marcovina S, Lovato L, Lovato J, Margolis KL, Davatzikos C, Barzilay J, Ginsberg HN, Linz PE, Miller ME.. JAMA Intern Med. 2014;174(3):324-333.

Independence of familial transmission of mania and depression: results of the NIMH family study of affective spectrum disorders. Merikangas KR, Cui L, Heaton L, Nakamura E, Roca C, Ding J, Qin H, Guo W, Shugart YY, Zarate C, Angst J.. Mol Psychiatry. 2014;19(2):214-219.

Periaortic fat and cardiovascular risk: a comparison of high-risk older adults and age-matched healthy controls. Brinkley TE, Leng X, Chughtai HL, Nicklas BJ, Kritchevsky SB, Ding J, Kitzman DW, Hundley WG.. Int J Obes (Lond). 2014;38(11):1397-1402.

The impact of sarcopenia on a physical activity intervention: the Lifestyle Interventions and Independence for Elders Pilot Study (LIFE-P). Liu CK, Leng X, Hsu FC, Kritchevsky SB, Ding J, Earnest CP, Ferrucci L, Goodpaster BH, Guralnik JM, Lenchik L, Pahor M, Fielding RA.. J Nutr Health Aging. 2014;18(1):59-64.

Computed tomography-derived cardiovascular risk markers, incident cardiovascular events, and all-cause mortality in nondiabetics: the Multi-Ethnic Study of Atherosclerosis. Yeboah J, Carr JJ, Terry JG, Ding J, Zeb I, Liu S, Nasir K, Post W, Blumenthal RS, Budoff MJ.. Eur J Prev Cardiol. 2014;21(10):1233-1241.

The cross-sectional and longitudinal associations of diabetic retinopathy with cognitive function and brain MRI findings: the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. Hugenschmidt CE, Lovato JF, Ambrosius WT, Bryan RN, Gerstein HC, Horowitz KR, Launer LJ, Lazar RM, Murray AM, Chew EY, Danis RP, Williamson JD, Miller ME, Ding J.. Diabetes Care. 2014;37(12):3244-3252.

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Postmus I, Trompet S, Deshmukh HA, Barnes MR, Li X, Warren HR, Chasman DI, Zhou K, Arsenault BJ, Donnelly LA, Wiggins KL, Avery CL, Griffin P, Feng Q, Taylor KD, Li G, Evans DS, Smith AV, de Keyser CE, Johnson AD, de Craen AJ, Stott DJ, Buckley BM,.. Nat Commun. 2014;5():5068.

Age-related variations in the methylome associated with gene expression in human monocytes and T cells. Reynolds LM, Taylor JR, Ding J, Lohman K, Johnson C, Siscovick D, Burke G, Post W, Shea S, Jacobs DR Jr, Stunnenberg H, Kritchevsky SB, Hoeschele I, McCall CE, Herrington DM, Tracy RP, Liu Y.. Nat Commun. 2014;5():5366.

Visceral adiposity and the risk of metabolic syndrome across body mass index: the MESA study. Shah RV, Murthy VL, Abbasi SA, Blankstein R, Kwong RY, Goldfine AB, Jerosch-Herold M, Lima JA, Ding J, Allison MA.. JACC Cardiovasc Imaging. 2014;7(12):1221-1235.

A genome-wide association study of depressive symptoms. Hek K, Demirkan A, Lahti J, Terracciano A, Teumer A, Cornelis MC, Amin N, Bakshis E, Baumert J, Ding J, Liu Y, Marciante K, Meirelles O, Nalls MA, Sun YV, Vogelzangs N, Yu L, Bandinelli S, Benjamin EJ, Bennett DA, Boomsma D,.. Biol Psychiatry. 2013;73(7):667-678.

Pericardial adipose tissue and coronary artery calcification in the Multi-ethnic Study of Atherosclerosis (MESA. McClain J, Hsu F, Brown E, Burke G, Carr J, Harris T, Kritchevsky S, Szklo M, Tracy R, Ding J.. Obesity (Silver Spring). 2013;21(5):1056-1063.

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Monda KL, Chen GK, Taylor KC, Ng MCY, Liu Y, Freedman BI, Howard TD, Langefeld CD, Lohman K, Palmer ND, Shriner DA, Burke G, Ding J, et al.. Nat Genet. 2013;45(6):690-696.

Aging-related geniohyoid muscle atrophy is related to aspiration status in healthy older adults. Feng X, Todd T, Lintzenich CR, Ding J, Carr JJ, Ge Y, Browne JD, Kritchevsky SB, Butler SG.. J Gerontol A Biol Sci Med Sci. 2013;68(7):853-860.

Genome-wide association of body fat distribution in african ancestry populations suggests new Loci. Liu CT, Monda KL, Taylor KC, Lange L, Demerath EW, Palmas W, Wojczynski MK, Ellis JC, Vitolins MZ, Liu S, Papanicolaou GJ, Irvin MR, Xue L, Griffin PJ, Nalls MA, Adeyemo A, Liu J, Li G, Ruiz-Narvaez EA, Chen WM, Chen F,.. PLoS Genet. 2013;9(8):e1003681.

The prospective association of Chlamydia pneumoniae and four other pathogens with development of coronary artery calcium: the Multi-Ethnic Study of Atherosclerosis (MESA). Laek B, Szklo M, McClelland RL, Ding J, Tsai MY, Bluemke DA, Tracy R, Matsushita K.. Atherosclerosis. 2013;230(2):268-274.

Meta-analysis of genome-wide association studies identifies six new loci for serum calcium concentrations. O'Seaghdha CM, Wu H, Yang Q, Kapur K, Guessous I, Zuber AM, Kottgen A, Stoudmann C, Teumer A, Kutalik Z, Mangino M, Dehghan A, Zhang W, Eiriksdottir G, Li G, Tanaka T, Portas L, Lopez LM, Hayward C, Lohman K,.. PLoS Genet. 2013;9(9):e1003796.

Methylomics of gene expression in human monocytes. Liu Y, Ding J, Reynolds LM, Lohman K, Register TC, De La Fuente A, Howard TD, Hawkins GA, Cui W, Morris J, Smith SG, Barr RG, Kaufman JD, Burke GL, Post W, Shea S, McCall CE, Siscovick D, Jacobs DR Jr, Tracy RP,.. Hum Mol Genet. 2013;22(24):5065-5074.

Beyond breast cancer: mammographic features and mortality risk in a population of healthy women. Murphy RA, Schairer C, Gierach GL, Byrne C, Sherman ME, Register TC, Ding J, Kritchevsky SB, Harris TB.. PLoS One. 2013;8(10):e78722.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Gerontology and Geriatric Medicine

Jingzhong Ding, Ph.D.

Jingzhong Ding, Ph.D.

Associate Professor, Gerontology and Geriatric Medicine
Ctr for Vaccines at Extremes
Epidemiology & Prevention

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