Profile

Debra I. Diz, Ph.D.Wake Forest School of Medicine

Education & Training

  • B.A., Randolph-Macon Womans College, 1976
  • Ph.D., University of Tennessee-Memphis, 1980
  • Fellowship, National Institutes Hlth, 1983

Memberships

  • Western Nc Chpt Soc For Neuros
  • Am Heart Association
  • Am Physiological Society
  • Am Soc for Pharm & Exper Ther
  • Cons for SE Hypertension Contr
  • Council For High Blood Pressur
  • Inter-Amer Soc of Hypertension
Debra I. Diz, Ph.D.

Debra I. Diz, Ph.D.

Director, Hypertension and Vascular Research Center
Professor, Hypertension
Brain Tumor Center of Excellence
Maya Angelou Center for Health Equity
Hypertension and Vascular Research Center
Center for Diabetes Research
Physiology & Pharmacology
Translational Science Institute

Research Interests

aging, atherosclerosis/thrombosis, biotechnology, cancer/oncogenesis, diabetes, education outreach, education/training (all f, t,, hypertension, neurosciences/behavior, vascular diseases

Contact Information

Academic: 336-716-2150 | Department: 336-716-2150

Email: ddiz@wakehealth.edu

Recent Publications

Liu C, Wajih N, Liu X, Basu S, Janes J, Marvel M, Keggi C, Helms CC, Lee AN, Belanger AM, Diz DI, Laurienti PJ, Caudell DL, Wang J, Gladwin MT, Kim-Shapiro DB. Mechanisms of human erythrocytic bioactivation of nitrite. J Biol Chem. 2015;290(2):1281-1294.

Schaich CL, Shaltout HA, Grabenauer M, Thomas BF, Gallagher PE, Howlett AC, Diz DI. Alterations in the medullary endocannabinoid system contribute to age-related impairment of baroreflex sensitivity. J Cardiovasc Pharmacol. 2015;65(5):473-479.

Lawson MJ, Figueroa JP, Rose JC, Chappell MC, Diz DI, Shaltout HA. Intracerebroventricular infusion of angiotensin-(1-7) improves baroreflex sensitivity in antenatal betamethasone exposed sheep [abstract]. FASEB J. 2015;29(1 Suppl):811.30.

Lawson MJ, Shaltout HA, Chappell MC, Diz DI, Figueroa JP. Obesity induces further autonomic impairment in sheep exposed antenatally to betamethasone [abstract]. FASEB J. 2015;29(1 Suppl):LB724.

Gardner AR, Diz DI, Tooze JA, Miller CD, Petty J. Injury patterns associated with hypotension in pediatric trauma patients: a national trauma database review. J Trauma Acute Care Surg. 2015;78(6):1143-1148.

Chappell MC, Marshall AC, Alzayadneh EM, Shaltout HA, Diz DI. Update on the angiotensin converting enzyme 2-angiotensin (1-7)-Mas receptor axis: fetal programing, sex differences, and intracellular pathways. Front Endocrinol (Lausanne). 2014;4():201.

Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC. Enhanced activity of an angiotensin-(1-7) neuropeptidase in glucocorticoid-induced fetal programming. Peptides. 2014;52():74-81.

Washburn LK, Brosnihan KB, Chappell MC, Diz DI, Gwathmey TM, Nixon PA, Russell GB, Snively BM, O'Shea TM. The renin-angiotensin-aldosterone system in adolescent offspring born prematurely to mothers with preeclampsia. J Renin Angiotensin Aldosterone Syst. 2014;():.

Marshall AC, Pirro NT, Rose JC, Diz DI, Chappell MC. Evidence for an angiotensin-(1-7) neuropeptidase expressed in the brain medulla and CSF of sheep. J Neurochem. 2014;130(2):313-323.

Tarbell SE, Shaltout HA, Wagoner AL, Diz DI, Fortunato JE. Relationship among nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained nausea. Exp Brain Res. 2014;232(8):2645-2650.

de Lima DC, Nascimento K, Shaltout HA, Coimbra CC, Diz DI. The metabolic challenge induced by hypercaloric diet leads to increased activity of the HPA axis and cardiac autonomic dysfunction in rats with low glial angiotensinogen [abstract]. FASEB J. 2014;28(1 Suppl):831.3.

Marshall A, Pirro N, Rose J, Diz D, Chappell M. Evidence for an angiotensin-(1-7) neuropeptidase in the brain medulla of sheep [abstract]. FASEB J. 2014;28(1 Suppl):1140.6.

Fortunato JE, Wagoner AL, Harbinson RL, D'Agostino RB Jr, Shaltout HA, Diz DI. Effect of fludrocortisone acetate on chronic unexplained nausea and abdominal pain in children with orthostatic intolerance. J Pediatr Gastroenterol Nutr. 2014;59(1):39-43.

Schaich C, Thomas B, Grabenauer M, Howlett A, Diz D. Blockade of CB1 receptors reveals that elevated medullary endocannabinoids contribute to age-related impairment of baroreflex sensitivity in Sprague-Dawley rats [abstract]. FASEB J. 2014;28(1 Suppl):681.4.

Schaich C, Howlett A, Brosnihan K, Diz D. Differential blood pressure response in normotensive rats and rats with angiotensin II-dependent hypertension following systemic cannabinoid CB1 receptor blockade [abstract]. FASEB J. 2014;28(1 Suppl):1140.11.

Schaich CL, Shaltout HA, Brosnihan KB, Howlett AC, Diz DI. Acute and chronic systemic CB1 cannabinoid receptor blockade improves blood pressure regulation and metabolic profile in hypertensive (mRen2)27 rats. Physiol Rep. 2014;2(8):e12108.

Arnold AC, Diz DI. Endogenous leptin contributes to baroreflex suppression within the solitary tract nucleus of aged rats. Am J Physiol Heart Circ Physiol. 2014;307(11):H1539-1546.

Miller GD, Isom S, Morgan TM, Vitolins MZ, Blackwell C, Brosnihan KB, Diz DI, Katula J, Goff D. Effects of a community-based weight loss intervention on adipose tissue circulating factors. Diabetes Metab Syndr. 2014;8(4):205-211.

Shaltout HA, Wagoner AL, Fortunato JE, Diz DI. Impaired hemodynamic response to head up tilt in adolescents presenting with chronic nausea and orthostatic intolerance [abstract]. Hypertension. 2014;64(Suppl 1):A513.

Wagoner AL, Shaltout HA, Diz DI, Fortunato JE. Novel neurohumoral responses to head upright tilt testing in children with chronic nausea and orthostatic intolerance [abstract]. Hypertension. 2014;64(Suppl 1):A033.

Shaltout HA, Marsh AP, Laurienti P, Basu S, Klebous CC, Kus N, Morgan A, DosSantos PC, Norris JL, Miller G, Rejeski J, Hawfield AT, Diz DI, Kim-Shapiro DB. Effect of adding beet root juice to exercise on physical performance and cardiovascular measures in old hypertensive subjects [abstract]. Hypertension. 2014;64(Suppl 1):A462.

Diz DI. Another chapter in the understanding of angiotensin-catecholamine interactions relevant to blood pressure control. Exp Physiol. 2014;99(12):1595-1596.

Arnold AC, Gallagher PE, Diz DI. Brain renin-angiotensin system in the nexus of hypertension and aging. Hypertens Res. 2013;36(1):5-13.

Nautiyal M, Arnold AC, Chappell MC, Diz DI. The brain renin-angiotensin system and mitochondrial function: influence on blood pressure and baroreflex in transgenic rat strains. Int J Hypertens. 2013;2013():136028.

Nautiyal M, Shaltout HA, de Lima DC, do Nascimento K, Chappell MC, Diz DI. Response to angiotensin-(1-7) and bradykinin in baroreceptor reflex sensitivity in hypertension [letter]. Hypertension. 2013;61(2):e20.

Marshall AC, Shaltout HA, Nautiyal M, Rose JC, Chappell MC, Diz DI. Fetal betamethasone exposure attenuates angiotensin-(1-7)-Mas receptor expression in the dorsal medulla of adult sheep. Peptides. 2013;44(C):25-31.

Yamaleyeva LM, Neves LA, Coveleskie K, Diz DI, Gallagher PE, Brosnihan KB. AT1, AT2, and AT1-7 receptor expression in the uteroplacental unit of normotensive and hypertensive rats during early and late pregnancy. Placenta. 2013;34(6):497-502.

Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC. Differential expression of renin-angiotensin system components in the choroid plexus of betamethasone exposed and control sheep [abstract]. FASEB J. 2013;27(Meeting Abstracts):1107.12.

Nautiyal M, Shaltout HA, Chappell MC, Diz DI. Reduction in central mitochondrial ROS improves cardiovagal baroreflex function independent of blood pressure in (mRen2)27 rats [abstract]. FASEB J. 2013;27(Meeting Abstracts):890.4.

Pulgar VM, Jeffers AB, Rashad HM, Diz DI, Aileru AA. Increased constrictor tone induced by ouabain treatment in rats. J Cardiovasc Pharmacol. 2013;62(2):174-183.

Schaich C, Nautiyal M, Howlett A, Chappell M, Diz D. Enhanced CB1 cannabinoid receptor tone contributes to impaired baroreflex sensitivity in hypertensive (mRen2)27 transgenic rats [abstract]. FASEB J. 2013;27():926.13.

Awumey EM, Bridges LE, Williams CL, Diz DI. Nitric-oxide synthase knockout modulates Ca2+-sensing receptor expression and signaling in mouse mesenteric arteries. J Pharmacol Exp Ther. 2013;346(1):38-47.

Marzetti E, Calvani R, DuPree J, Lees HA, Giovannini S, Seo DO, Buford TW, Sweet K, Morgan D, Strehler KY, Diz D, Borst SE, Moningka N, Krotova K, Carter CS. Late-life enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle. Age (Dordr). 2013;35(4):1061-1075.

Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC. Antenatal betamethasone exposure is associated with lower ANG-(1-7) and increased ACE in the CSF of adult sheep. Am J Physiol Regul Integr Comp Physiol. 2013;305(7):R679-R688.

Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC. Antenatal betamethasone exposure reduces Ang-(1-7) but enhances angiotensin-converting enzyme and a thiol peptidase to metabolize Ang-(1-7) in the cerebrospinal fluid [abstract]. Hypertension. 2013;62(3 Suppl):177.

Nautiyal M, Shaltout HA, Chappell MC, Diz DI. Combined intracerebroventricular angiotensin-(1-7) and candesartan normalizes blood pressure and improves baroreflex function in transgenic (mRen2)27 hypertensive rats [abstract]. Hypertension. 2013;62(3 Suppl):607.

Schaich CL, Howlett AC, Thomas BF, Grabenauer MA, Diz DI. Medullary endocannabinoid content contributes to the differential resting baroreflex sensitivity in rats with altered brain renin-angiotensin system expression [abstract]. Hypertension. 2013;62(3 Suppl):182.

Fortunato JE, Wagoner AL, Shaltout HA, Diz DI. Increase in arginine vasopressin is associated with the reduction in blood pressure in patients with chronic nausea and orthostatic intolerance [abstract]. J Pediatr Gastroenterol Nutr. 2013;57(Suppl 1):e97.

Schaich C, Shaltout HA, Howlett AC, Diz DI. Chronic systemic CB1 cannabinoid receptor blockade reduces blood pressure and weight gain and improves baroreflex function and heart rate variability in hypertensive (mRen2)27 rats [abstract]. Hypertension. 2013;62(3 Suppl):183.

Wagoner AL, Shaltout HA, D'Agostino RB, Diz DI, Fortunato JE. Relationship of arginine vasopressin and blood pressure in patients with orthostatic intolerance and nausea [abstract]. Hypertension. 2013;62(3 Suppl):261.

Miller G, Blackwell CS, Vitolins M, Isom S, Morgan TM, Brosniham KB, Diz DI, Katula JA, Goff DC. A community-based weight loss intervention in obese adults improves adipose tissue circulating factors independently of baseline glucose tolerance [abstract]. In: Obesityweek 2013 November 11-16; Atlanta (GA). 2013;():S86.

Nautiyal M, Tommasi E, Chappell MC, Diz DI. MAP kinase phosphatase-1 inhibitor injection into the solitary tract nucleus impairs cardiovagal baroreflex function in transgenic ASrAOGEN rats [abstract]. Hypertension. 2013;62(3 Suppl):A157.

Diz DI, Schaich CL, Thomas BF, Grabenauer MA, Chappell MC, Howlett AC. Elevated endocannabinoids via CB1receptors in the solitary tract nucleus contibute to age-related impairments in baroreflex sensitivity in Sprague-Dawley rats [abstract]. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

Hakuda D, Thomas BF, Yamaleyeva LM, Grabenauer MA, Diz, DI, Chappell MC. Enhanced expression of 2-arachidonoylglycerol in the kidney of diabetic hypertensive rats [abstract]. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

Schaich CL, Howlett A, Thomas B, Grabenauer M, Chappell M, Diz D. Chronic systemic CB1 cannabinoid receptor blockade reduces weight gain and lowers blood pressure in hypertensive (mRen2)27 rats [abstract]. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

Schaich CL, Howlett A, Thomas B, Grabenauer M, Chappell M, Diz D. Chronic systemic CB1 cannabinoid receptor blockade reduces weight gain and lowers blood pressure in hypertensive (mRen2)27 rats [abstract]. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 June 21-26; Vancouver (CA). 2013;():.

Hakuda D, de Lima R, Pirro N, Diz D, Chappell M. High glucose differentially influences endocannabinoid CB-1 and CB-2 receptors in renal epithelial cells [abstract]. FASEB J. 2013;27(Meeting Abstracts):917.9.

Shaltout HA, Rose JC, Chappell MC, Diz DI. Angiotensin-(1-7) deficiency and baroreflex impairment precede the antenatal betamethasone exposure-induced elevation in blood pressure. Hypertension. 2012;59(2):453-458.

de Lima DC, Shaltout HA, Coimbra CC, Diz DI. Metabolic and cardiovascular adjustments to hemorrhage in [TGR(ASrAogen)] rats and (mRen2) 27 rats [abstract]. FASEB J. 2012;26(Meeting Abstracts):891.7.

Marshall AC, Shaltout HA, Nautiyal M, Chappell MC, Diz DI. Fetal betamethasone exposure and age influence the expression of AT7/mas receptors in the solitary tract nucleus [abstract]. FASEB J. 2012;26(Meeting Abstracts):1101.12.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Hypertension

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