Profile

Debra I. Diz, Ph.D.

Debra I. Diz, Ph.D.

Professor, Surgical Sciences-Hypertension
Translational Science Institute
Hypertension and Vascular Research Center
Maya Angelou Center for Health Equity
Center for Biomolecular Imaging
Center for Diabetes Research
Brain Tumor Center of Excellence
Translational Science Institute
Physiology & Pharmacology

Contact Information

Academic: 336-716-2150 | Department: 336-716-2150

Email: ddiz@wakehealth.edu

Education & Training

  • B.A., Randolph-Macon Womans College , 1976
  • Ph.D., University of Tennessee-Memphis , 1980
  • Fellowship, National Institutes Hlth, 1983

Memberships

  • Western Nc Chpt Soc For Neuros
  • Am Heart Association
  • Am Physiological Society
  • Am Soc Of Pharm & Exper Therap
  • Cons for SE Hypertension Contr
  • Council For High Blood Pressur
  • Inter-Amer Soc of Hypertension
Debra I. Diz, Ph.D.

Debra I. Diz, Ph.D.

Professor, Surgical Sciences-Hypertension Translational Science Institute
Hypertension and Vascular Research Center
Maya Angelou Center for Health Equity
Center for Biomolecular Imaging
Center for Diabetes Research
Brain Tumor Center of Excellence
Translational Science Institute
Physiology & Pharmacology

Research Interests

aging, education outreach, fitness/physical, hormones/cytokines/signalling, hypertension, metabolism

Contact Information

Academic: 336-716-2150 | Department: 336-716-2150

Email: ddiz@wakehealth.edu

Recent Publications

Arnold AC, Gallagher PE, Diz DI. Brain renin-angiotensin system in the nexus of hypertension and aging. Hypertens Res. 2013;36(1):5-13.




de Lima DC, Shaltout HA, Coimbra CC, Diz DI. Metabolic and cardiovascular adjustments to hemorrhage in [TGR(ASrAogen)] rats and (mRen2) 27 rats [abstract]. FASEB J. 2012;26(Meeting Abstracts):891.7.

Marshall AC, Shaltout HA, Nautiyal M, Chappell MC, Diz DI. Fetal betamethasone exposure and age influence the expression of AT7/mas receptors in the solitary tract nucleus [abstract]. FASEB J. 2012;26(Meeting Abstracts):1101.12.

Arnold AC, Nautiyal M, Diz DI. Protein phosphatase 1b in the solitary tract nucleus is necessary for normal baroreflex function. J Cardiovasc Pharmacol. 2012;59(5):472-478.

Garcia-Espinosa MA, Shaltout HA, Gallagher PE, Chappell MC, Diz DI. In vivo expression of angiotensin-(1-7) lowers blood pressure and improves baroreflex function in transgenic (mRen2)27 rats. J Cardiovasc Pharmacol. 2012;60(2):150-157.

Lee TC, Greene-Schloesser D, Payne V, Diz DI, Hsu F-C, Kooshki M, Mustafa R, Riddle DR, Zhao W, Chan MD, Robbins ME. Chronic administration of the angiotensin-converting enzyme inhibitor, ramipril, prevents fractionated whole-brain irradiation-induced perirhinal cortex-dependent cognitive impairment. Radiat Res. 2012;178(1):46-56.

Nautiyal M, Shaltout HA, de Lima DC, do Nascimento K, Chappell MC, Diz DI. Central angiotensin-(1-7) improves vagal function independent of blood pressure in hypertensive (mRen2)27 rats. Hypertension. 2012;60(5):1257-1265.

Nautiyal M, Katakam PV, Busija DW, Gallagher PE, Tallant EA, Chappell MC, Diz DI. Differences in oxidative stress status and expression of MKP-1 in dorsal medulla of transgenic rats with altered brain renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol. 2012;303(8):R799-806.

Awumey EM, Bridges LE, Williams CL, Diz DI. Nitric oxide synthase knockout modulates Ca2+-sensing receptor expression and signaling in mesenteric arteries [abstract]. FASEB J. 2012;26():671.5.

Pulgar VM, Rashad HM, Jeffers AB, Dickenson SR, Diz DI, Aileru AA. Na-K-ATPase isoform profile in acquired and genetic forms of hypertension favors the hypertensive phenotype [abstract]. FASEB J. 2012;26(Meeting Abstracts Suppl):872.30.

Arnold AC, Sakima A, Kasper SO, Vinsant S, Garcia-Espinosa MA, Diz DI. The brain renin-angiotensin system and cardiovascular responses to stress: insights from transgenic rats with low brain angiotensinogen. J Appl Phys. 2012;113(12):1929-1936.

Groban L, Wang H, Machado FSM, Trask AJ, Kritchevsky SB, Ferrario CM, Diz DI. Low glial angiotensinogen improves body habitus, diastolic function, and exercise tolerance in aging male rats. Cardiovasc Endocrinol. 2012;1(1):49-58.

Gwathmey TM, Shaltout HA, Rose JC, Diz DI, Chappell MC. Glucocorticoid-induced fetal programming alters the functional complement of angiotensin receptor subtypes within the kidney. Hypertension. 2011;57(3):620-626.


Diz DI, Arnold AC, Nautiyal M, Isa K, Shaltout HA, Tallant EA. Angiotensin peptides and central autonomic regulation. Curr Opin Pharmacol. 2011;11(2):131-137.

Arnold AC, Shaltout HA, Gilliam-Davis S, Kock ND, Diz DI. Autonomic control of the heart is altered in Sprague-Dawley rats with spontaneous hydronephrosis. Am J Physiol Heart Circ Physiol. 2011;300(6):H2206-2213.

Shaltout HA, Chappell MC, Rose JC, Diz DI. Exaggerated sympathetic mediated responses to behavioral or pharmacological challenges following antenatal betamethasone exposure. Am J Physiol Endocrinol Metab. 2011;300(6):E979-985.

Gilliam-Davis S, Gallagher PE, Payne VS, Kasper SO, Tommasi EN, Westwood BM, Robbins ME, Chappell MC, Diz DI. Long-term systemic angiotensin II type 1 receptor blockade regulates mRNA expression of dorsomedial medulla renin-angiotensin system components. Physiol Genomics. 2011;43(13):829-835.

Logan EM, Aileru AA, Shaltout HA, Averill DB, Diz DI. The functional role of PI3K in maintenance of blood pressure and baroreflex suppression in (mRen2)27 and mRen2.Lewis rat. J Cardiovasc Pharmacol. 2011;58(4):367-373.

Diz DI, Garcia-Espinosa MA, Shaltout HA, Olson J, Bourland JD, Groban L. Correlation of the brain medullary metabolites N-acetyl aspartic acid and N-acetyl aspartyl glutamate with the age related decline in sensitivity for baroreflex control of heart rate in humans [abstract]. Hypertension. 2011;58(5):e116.

de Lima DC, Shaltout HA, Coimbra CC, Diz DI. Hypercaloric diet impairs cardiovascular but not metabolic adjustments to hemorrhage in older [TGR (ASrAOGEN)] rats [abstract]. Hypertension. 2011;58(5):e164.

Fortunato JE, Diz DI, Shaltout HA. Fludrocortisone acetate improves baroreflex sensitivity and heart rate variability during tilt in children with postural orthostatic tachycardia syndrome [abstract]. Hypertension. 2011;58(5):e117.

Fortunato JE, Shaltout HA, Larkin MM, Rowe PC, Diz DI, Koch KL. Fludrocortisone improves nausea in children with orthostatic intolerance (OI). Clin Auton Res. 2011;21(6):419-423.

Marshall A, Shaltout HA, Nautiyal M, Arter A, Chappell MC, Diz DI. Localization and regulation of angiotensin receptor subtypes in sheep solitary tract nucleus: effects of in utero exposure to glucocorticoid [abstract]. Hypertension. 2011;58(5):e75.

Nautiyal M, Shaltout HA, Chappell MC, Diz DI. Chronic intracerebroventricular angiotensin-(1-7) infusion, but not AT1 receptor blockade, improves vagal components of the baroreflex function in hypertensive (mRen2)27 transgenic rats [abstract]. Hypertension. 2011;58(5):e96.

Pulgar V, Jeffers A, Diz D, Aileru A. Vascular Na-K-ATPase activity in acquired and genetic forms of hypertension [abstract]. Hypertension. 2011;58(5):e88.

Schaich CL, Howlett AC, Diz DI. Dose-related biphasic modulation of baroreflex sensitivity by the CB1 receptor in rat solitary tract nucleus [abstract]. Hypertension. 2011;58(5):e105.


Fortunato JE Jr, Shaltout HA, Diz DI, Koch KL. Chronic idiopathic nausea in children associated with orthostatic intolerance improves after treatment with fludrocortisone [abstract]. Gastroenterology. 2011;140(5 Suppl 1):S-743.

Gwathmey TM, Pendergrass KD, Reid SD, Rose JC, Diz DI, Chappell MC. Angiotensin-(1-7)-angiotensin-converting enzyme 2 attenuates reactive oxygen species formation to angiotensin II within the cell nucleus. Hypertension. 2010;55(1):166-171.

Garcia-Espinosa MA, Shaltout HA, Olson J, Westwood BM, Robbins ME, Link K, Diz DI. Proton magnetic resonance spectroscopy detection of neurotransmitters in dorsomedial medulla correlate with spontaneous baroreceptor reflex function. Hypertension. 2010;55(2 Pt 2):487-493.

Westwood B, Gwathmey T, Shaltout H, Diz D, Rose J, Chappell M. Immunocytochemical distribution of the Ang-(1-7)/mas receptor in the sheep kidney [abstract]. FASEB J. 2010;24(1 Meeting Abstracts):605.6.

Arter A, Nautiyal M, Shaltout H, Chappell M, Diz D. Mas and AT1 receptor expression in adult sheep dorsomedial medulla [abstract]. FASEB J. 2010;24(1 Meeting Abstracts):625.5.

Shaltout HA, Rose JC, Chappell MC, Diz DI. Modulation of baroreflex sensitivity by endogenous angiotensins in lamb solitary tract nucleus [abstract]. FASEB J. 2010;24(1 Meeting Abstracts):624.7.

Nautiyal M, Tallant EA, Chappell MC, Diz DI. Mitogen-activated protein kinase phosphatase-1 (MKP-1) is low in dorsal medulla of hypertensive (mRen2)27 transgenic rats [abstract]. FASEB J. 2010;24(1 Meeting Abstracts):955.11.

Arnold AC, Diz DI. Aging is associated with resistance to the cardiovascular actions of leptin for baroreflex modulation [abstract]. FASEB J. 2010;24(1 Meeting Abstracts):624.8.

Logan E, Johnson A, Diz D, Aileru A. Pressor and baroreflex effects of ouabain in (mRen2)27 and mRen2.Lewis rats [abstract]. FASEB J. 2010;24(1 Meeting Abstracts):977.5.

Dhaunsi GS, Yousif MHM, Akhtar S, Chappell MC, Diz DI, Benter IF. Angiotensin-(1-7) prevents diabetes-induced attenuation in PPAR-gamma and catalase activities. Eur J Pharmacol. 2010;638(1-3):108-114.

Robbins ME, Zhao W, Garcia-Espinosa MA Diz DI. Renin-angiotensin system blockers and modulation of radiation-induced brain injury. Curr Drug Targets. 2010;11(11):1413-1422.

Shaltout HA, Rose JC, Figueroa JP, Chappell MC, Diz DI, Averill DB. Acute AT1-receptor blockade reverses the hemodynamic and baroreflex impairment in adult sheep exposed to antenatal betamethasone. Am J Physiol Heart Circ Physiol. 2010;299(2):H541-H547.

Arnold AC, Isa K, Shaltout HA, Nautiyal M, Ferrario CM, Chappell MC, Diz DI. Angiotensin-(1-12) requires angiotensin converting enzyme and AT1 receptors for cardiovascular actions within the solitary tract nucleus. Am J Physiol Heart Circ Physiol. 2010;299(3):H763-H771.

Arnold AC, Diz DI. Endogenous leptin within the solitary tract nucleus contributes to the suppression of baroreflex sensitivity in older anesthetized Sprague-Dawley rats [abstract]. Hypertension. 2010;56(5):e72.

Gwathmey TM, Westwood BM, Pirro NT, Tang L, Rose JC, Diz DI, Chappell MC. Nuclear angiotensin-(1-7) receptor is functionally coupled to the formation of nitric oxide. Am J Physiol Renal Physiol. 2010;299(5):F983-F990.

Lima DC, Coimbra CC, Diz DI. Hypercaloric diet impairs the cardiovascular and metabolic adjustments induced by hemorrhage in rats deficient in brain angiotensinogen [TGR (ASrAogen)] [abstract]. Hypertension. 2010;56(5):e96-e97.

Nautiyal M, Katakam PV, Busija DW, Gallagher PE, Tallant EA, Chappell MC, Diz DI. Oxidative stress and low expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in dorsal medulla of hypertensive (mRen2)27 transgenic rats [abstract]. Hypertension. 2010;56(5):e156.

Schaich CL, Howlett AC, Diz DI. Attenuation of baroreflex sensitivity by cannabinoid receptor activation in rat solitary tract nucleus [abstract]. Hypertension. 2010;56(5):e105.

Shaltout HA, Rose JC, Chappell MC, Diz DI. Antenatal betamethasone exposure attenuates the functional role of angiotensin-(1-7) in the NTS [abstract]. Hypertension. 2010;56(5):e103.

Shaltout HA, Figueroa JP, Rose JC, Diz DI, Chappell MC. Alterations in circulatory and renal angiotensin-converting enzyme and angiotensin-converting enzyme 2 in fetal programmed hypertension. Hypertension. 2009;53(2):404-408.

Robbins ME, Payne V, Tommasi E, Diz DI, Hsu F-C, Brown WR, Wheeler KT, Olson J, Zhao W. The AT1 receptor antagonist, L-158,809, prevents or ameliorates fractionated whole-brain irradiation-induced cognitive impairment. Int J Radiat Oncol Biol Phys. 2009;73(2):499-505.

Al-Maghrebi M, Benter IF, Diz DI. Endogenous angiotensin-(1-7) reduces cardiac ischemia-induced dysfunction in diabetic hypertensive rats. Pharmacol Res. 2009;59(4):263-268.

Gwathmey TM, Shaltout HA, Pendergrass KD, Pirro NT, Figueroa JP, Rose JC, Diz DI, Chappell MC. Nuclear angiotensin II type 2 (AT2) receptors are functionally linked to nitric oxide production. Am J Physiol Renal Physiol. 2009;296(6):F1484-1493.

Isa K, Garcia-Espinosa MA, Arnold AC, Pirro NT, Tommasi EN, Ganten D, Chappell MC, Ferrario CM, Diz DI. Chronic immunoneutralization of brain angiotensin-(1-12) lowers blood pressure in transgenic (mRen2)27 hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2009;297(1):R111-115.

Pulgar VM, Hong JK, Jessup JA, Massmann AG, Diz DI, Figueroa JP. Mild chronic hypoxemia modifies expression of brain stem angiotensin peptide receptors and reflex responses in fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2009;297(2):R446-R452.

Anton L, Merrill DC, Neves LAA, Diz DI, Corthorn J, Stovall K, Gallagher PE, Moorefield C, Gruver C, Brosnihan KB, et al. The uterine placental bed renin-angiotensin system in normal and preeclamptic pregnancy. Endocrinology. 2009;150(9):4316-4325.

Arnold AC, Shaltout HA, Gallagher PE, Diz DI. Leptin impairs cardiovagal baroreflex function at the level of the solitary tract nucleus. Hypertension. 2009;54(5):1001-1008.

Arnold AC, Shaltout HA, Gallagher PE, Diz DI. Protein phosphatase 1b activity in the solitary tract nucleus is necessary for normal baroreflex function [abstract]. Hypertension. 2009;54(4):e100.

Awumey EM, Bridges LS, Diz DI. Endothelial nitric oxide synthase knockout and nitric oxide inhibition attenuate Ca2+-induced relaxation of isolated precontracted mouse mesenteric arteries [abstract]. Hypertension. 2009;54(4):e123.

Garcia-Espinosa MA, Shaltout HA, Olson J, Link K, Diz DI. In vivo proton magnetic resonance spectroscopy detection of neurotransmitter/metabolite concentrations in dorsomedial medulla as a noninvasive predictor of autonomic function [abstract]. Hypertension. 2009;54(4):e48.

Gilliam-Davis S, Tommasi EN, Garcia-Espinosa MA, Chappell MC, Brosnihan KB, Diz DI. Bilateral renal denervation prevents age-related proteinuria without altering excretion of intrarenal angiotensin peptides in Sprague-Dawley rats [abstract]. Hypertension. 2009;54(4):e76.

Gwathmey TM, Pendergrass KD, Shaltout HA, Reid SD, Rose JC, Diz DI, Chappell MC. Steroid-induced fetal programming differentially alters nuclear angiotensin II receptor expression and function [abstract]. Hypertension. 2009;54(4):e42.

Gwathmey TM, Pendergrass KD, Rose JC, Diz DI, Chappell MC. Nuclear angiotensin-(1-7) receptors mediate the production of nitric oxide [abstract]. Hypertension. 2009;54(4):e74.

Isa K, Arnold AC, Chappell MC, Diz DI. Angiotensin-converting enzyme inhibition, but not AT1 receptor blockade, in the solitary tract nucleus improves baroreflex sensitivity in anesthetized transgenic hypertensive (mRen2)27 rats [abstract]. Hypertension. 2009;54(4):e98.

Logan EM, Johnson A, Diz DI, Aileru A. Nicotinic and AT1 receptors show enhanced responsiveness in the superior cervical ganglia of (mRen2)27 versus Sprague-Dawley rats [abstract]. Hypertension. 2009;54(4):e85-e86.

Shaltout HA, Diz DI, Figueroa JP, Chappell MC, Rose JC. Sympathetic nervous system mediated responses to behavioral or pharmacologic challenges are exaggerated as a result of antenatal betamethasone exposure [abstract]. Hypertension. 2009;54(4):e101`.

Arnold AC, Diz DI. Baroreflex sensitivity is impaired in Sprague-Dawley rats with spontaneous hydronephrosis independent of angiotensin II actions in the solitary tract nucleus [abstract]. FASEB J. 2009;23(1 Meeting Abstracts):957.8.

Shaltout HA, Figueroa JP, Rose JC, Chappell MC, Averill DB, Diz DI. Antenatal betamethasone causes alterations in angiotensin receptors in sheep brain in a gender specific manner [abstract]. FASEB J. 2009;23(1 Meeting Abstracts):941.11.

Gilliam-Davis S, Tommasi EN, Garcia-Espinosa MA, Chappell MC, Diz DI. Bilateral renal denervation transiently lowers blood pressure and delays the development of proteinuria in aging Sprague-Dawley rats [abstract]. FASEB J. 2009;23(Meeting Abstracts):1015.2.

Benter IF, Yousif MHM, Dhaunsi GS, Kaur J, Chappell MC, Diz DI. Angiotensin-(1-7) prevents activation of NADPH oxidase and renal vascular dysfunction in diabetic hypertensive rats. Am J Nephrol. 2008;28(1):25-33.

Anton L, Merrill DC, Neves LAA, Stovall K, Gallagher PE, Diz DI, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. Activation of local chorionic villi angiotensin II levels but not angiotensin (1-7) in preelampsia. Hypertension. 2008;51(4):1066-1072.

Pulgar V, Diz D, Hong JK, Figueroa JP. Chronic mild hypoxemia during late gestation decreases baroreceptor gain in fetal sheep [abstract]. Reprod Sci. 2008;15(2 Suppl):129A.

Arnold AC, Sakima A, Ganten D, Ferrario CM, Diz DI. Modulation of reflex function by endogenous angiotensins in older transgenic rats with low glial angiotensinogen. Hypertension. 2008;51(5):1326-1331.

Awumey EM, Hill SK, Diz DI, Bukoski RD. Cytochrome P-450 metabolites of 2-arachidonoylglycerol play a role in Ca2+-induced relaxation of rat mesenteric arteries. Am J Physiol Heart Circ Physiol. 2008;294(5):H2363-2370.

Diz DI, Garcia-Espinosa MA, Gegick S, Tommasi EN, Ferrario CM, Tallant EA, Chappell MC, Gallagher PE. Injections of angiotensin-converting enzyme 2 inhibitor MLN4760 into nucleus tractus solitarii reduce baroreceptor reflex sensitivity for heart rate control in rats. Exp Physiol. 2008;93(5):694-700.

Diz DI, Varagic J, Groban L. Aging and the brain renin-angiotensin system: relevance to age-related decline in cardiac function. Future Cardiol. 2008;4(3):237-245.

Diz DI, Garcia-Espinosa MA, Gallagher PE, Ganten D, Ferrario CM, Averill DB. Angiotensin-(1-7) and baroreflex function in nucleus tractus solitarii of (mRen2)27 transgenic rats. J Cardiovasc Pharmacol. 2008;51(6):542-548.


Anton L, Merrill DC, Diz D, Neves LA, Gallagher PE, Stovall K, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. Elevation of maternal uterine placental bed angiotensin II levels is associated with increased renin and ACE mRNA in preeclampsia [abstract]. Hypertension. 2008;52(4):e49.

Arnold AC, Shaltout HA, Gallagher PE, Ganten D, Ferrario CM, Diz DI. Leptin impairs baroreflex sensitivity at the solitary tract nucleus: evidence for upregulation of leptin actions in animals with low brain angiotensinogen [abstract]. Hypertension. 2008;52(4):e50.

Awumey EM, Bridges LS, Diz DI. Inhibition of phospholipase A2 and K-Ca channels attenuates calcium-induced relaxation of isolated, phenylephrine-contracted rat mesenteric arteries [abstract]. Hypertension. 2008;52(4):e117.

Garcia-Espinosa MA, Shaltout HA, Chappell MC, Gallagher PE, Ferrario CM, Ganten D, Reudelhuber TL, Diz DI. Angiotensin-(1-7) replacement gene transfer in the cisterna magna lowers blood pressure and improves baroreflex function in transgenic (mRen2)27 rats [abstract]. Hypertension. 2008;52(4):e36.

Gilliam-Davis S, Gallagher PE, Payne VS, Kasper SO, Tommasi EN, Robbins ME, Diz DI. Long-term systemic renin-angiotensin system blockade alters expression of renin-angiotensin system components in dorsomedial medulla of Fischer 344 rats [abstract]. Hypertension. 2008;52(4):e61.

Isa K, Garcia-Espinosa MA, Arnold AC, Pirro NT, Tommasi EN, Ferrario CM, Chappell MC, Diz DI. Angiotensin-(1-12) contributes to renin-independent angiotensin II activity in brain [abstract]. Hypertension. 2008;52(4):e81.

Logan EM, Diz DI, Ferrario CM, Ganten D, Aileru AA. Differences in ganglionic transmission between (mRen)27 and mRen2.Lewis models of hypertension [abstract]. Hypertension. 2008;52(4):e65.

Logan EM, Diz DI, Ferrario CM, Ganten D, Averill DB. Inhibition of the PI3 kinase pathway in the nTS of hypertensive rats improves baroreceptor reflex sensitivity [abstract]. Hypertension. 2008;52(4):e80.

Shaltout HA, Figueroa JP, Rose JC, Diz DI, Chappell MC. Reduced renal ACE2 in fetal programmed hypertension [abstract]. Hypertension. 2008;52(4):e52.

Shaltout HA, Figueroa JP, Rose JC, Chappell MC, Averill DB, Diz DI. Evidence of Ang-(1-7) deficiency in antenatal betamethasone-treated young adult sheep [abstract]. Hypertension. 2008;52(4):e107.


Robbins M, Payne V, Diz D, Hsu FC, Zhao WL. Chronic inhibition of the renin-angiotensin system prevents radiation-induced cognitive impairment in the adult male rat [abstract]. Neuro Oncol. 2008;10(5):851.


Shaltout HA, Westwood BM, Averill DB, Ferrario CM, Figueroa JP, Diz DI, Rose JC, Chappell MC. Angiotensin metabolism in renal proximal tubules, urine and serum of sheep: evidence for ACE2-dependent processing of angiotensin II. Am J Physiol Renal Physiol. 2007;292(1):F82-F91.

Diz DI, Kasper SO, Sakima A, Ferrario CM. Aging and the brain renin-angiotensin system: insights from studies in transgenic rats. Cleve Clin J Med. 2007;74(Suppl 1):S95-S98.

Sakima A, Averill DB, Kasper SO, Jackson L, Ganten D, Ferrario CM, Gallagher PE, Diz DI. Baroreceptor reflex regulation in anesthetized transgenic rats with low glia-derived angiotensinogen. Am J Physiol Heart Circ Physiol. 2007;292(3):H1412-1419.

Benter IF, Yousif MHM, Cojocel C, Al-Maghrebi M, Diz DI. Angiotensin-(1-7) prevents diabetes-induced cardiovascular dysfunction. Am J Physiol Heart Circ Physiol. 2007;292(1):H666-H672.

Arnold AC, Sakima A, Ganten D, Ferrario CM, Diz DI. Baroreceptor reflex regulation in anesthetized older transgenic rats with low brain angiotensinogen: role of endogenous angiotensin II and angiotensin-(1-7) [abstract]. FASEB J. 2007;21(6 Pt II):A889.

Shaltout HA, Figueroa JP, Rose JC, Chappell MC, Averill DB, Diz DI. Gender differences in the development of insulin resistance in adult sheep as result of antenatal betamethasone [abstract]. FASEB J. 2007;21(5 Pt I):A434.

Awumey EM, Howlett AC, Putney JW Jr, Diz DI, Bukoski RD. Ca2+ mobilization through dorsal root ganglion Ca2+-sensing receptor stably expressed in HEK293 cells. Am J Physiol Cell Physiol. 2007;292(5):C1895-1905.

Gilliam-Davis S, Payne VS, Kasper SO, Tommasi EN, Robbins ME, Diz DI. Long-term AT1 receptor blockade improves metabolic function and provides renoprotection in Fischer-344 rats. Am J Physiol Heart Circ Physiol. 2007;293(3):H1327-33.

Zhao W, Diz DI, Robbins ME. Oxidative damage pathways in relation to normal tissue injury. Br J Radiol. 2007;80(Special Issue 1):S23-S31.

Anton L, Merrill DC, Diz DI, Neves LA, Stovall K, Gallagher PE, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. The increased shift of the Ang II/Ang-(1-7) balance in the chorionic villi from preeclamptic subjects is mediated by the AT1 receptor [abstract]. Hypertension. 2007;50(4):e79.

Arnold AC, Sakima A, Ganten D, Ferrario CM, Diz DI. Ang II and Ang-(1-7) in the solitary tract nucleus participate in the anesthesia-induced elevation of mean arterial pressure in older rats with low glial angiotensinogen [abstract]. Hypertension. 2007;50(4):e116.

Gilliam-Davis S, Chappell MC, Diz DI. Elevated angiotensin I and creatinine excretion precede the increase in proteinuria during aging in Sprague-Dawley rats [abstract]. Hypertension. 2007;50(4):e121.

Gwathmey TM, Diz DI, Pirro NT, Figueroa J, Rose JC, Chappell MC. Nuclear angiotensin II-type 2 receptors are differentially expressed in the sheep kidney [abstract]. Hypertension. 2007;50(4):e97.

Logan EM, Ferrario CM, Diz DI, Averill DB. The PI3 kinase signal transduction pathway in nucleus tractus solitarii participates in maintenance of resting arterial [abstract]. Hypertension. 2007;50(4):e116.

Sesay JS, Diz DI, Howlett AC, Awumey EM. Ca2+-sensing receptor signaling in mouse neuroblastoma cells: a model for the perivascular sensory nerve Ca2+-sensing receptor [abstract]. Hypertension. 2007;50(4):e124.

Yousif MH, Benter IF, Diz DI, Chappell MC. Evidence that multiple receptor subtypes mediate angiotensin-(1-7) dependent vasodilation of the rat renal artery [abstract]. Hypertension. 2007;50(4):e154-e155.

Groban L, Ferrario CM, Ganten D, Diz DI. Transgenic rats with low brain renin-angiotensin system activity due to glial deficiency are protected against heart failure late in life [abstract]. J Card Fail. 2007;13(6 Suppl 2):S83.

Ferrario CM, Averill DB, Brosnihan KB, Chappell MC, Diz DI, Gallagher PE, Neves L, Tallant EA. Regulation of cardiovascular control mechanisms by angiotensin (1-7) and angiotensin-converting enzyme 2 In: Carey RM, ed. Hypertension and hormone mechanisms. Totowa (NJ): Humana Press;2007: 43-59.

Kasper SO, Ferrario CM, Ganten D, Diz DI. Rats with low brain angiotensinogen do not exhibit insulin resistance during early aging. Endocrine. 2006;30(2):167-174.

Awumey EM, Diz DI, Howlett AC, Putney JW Jr. Downregulation of protein kinase C inhibits perivascular sensory nerve Ca2+-sensing receptor signaling [abstract]. Hypertension. 2006;48(4):e85-e86.

Benter IF, Yousif MH, Cojocel C, Al-Maghrebi M, Diz DI. Renal dysfunction in diabetic SHR is attenuated by treatment with angiotensin-(1-7) [abstract]. Hypertension. 2006;48(4):e101.

Diz DI, Tommasi EN, Ferrario CM, Tallant EA, Gallagher PE. ACE2 inhibition in the nucleus of the solitary tract reduces baroreceptor reflex sensitivity [abstract]. Hypertension. 2006;48(4):e87.

Garcia-Espinosa MA, Gallagher PE, Ganten D, Ferrario CM, Reudlehuber TL, Diz DI. Intracisternal injection of angiotensin-(1-7)-producing fusion protein plasmid lowers blood pressure in hypertensive (mRen2)27 rats [abstract]. Hypertension. 2006;48(4):e87.

Sakima A, Averill DB, Kasper SO, Tommasi E, Gilliam-Davis S, Jackson L, Ganten D, Ferrario CM, Diz D. Cardiovascular and autonomic control in transgenic rats with low glial-derived angiotensinogen [abstract]. J Hypertens. 2006;24(Suppl 6):157.

Shaltout HA, Figueroa JP, Rose JC, Chappell M, Diz DI, Averill DB. Antenatal betamethasone causes angiotensin II-mediated impairment of cardiovascular function [abstract]. Hypertension. 2006;48(4):e32.

Shaltout HA, Figueroa JP, Rose JC, Chappell MC, Diz DI, Averill DB. Antenatal betamethasone causes angiotensin II-mediated impairment of baroreflex control of heart rate [abstract]. J Hypertens. 2006;24(Suppl 6):159.

Shaltout HA, Figueroa JP, Rose JC, Averill DB, Diz DI, Chappell MC. Increased blood pressure is associated with lower serum ACE2 activity and higher ACE activity following antenatal steroid exposure [abstract]. J Hypertens. 2006;24(Suppl 6):127.

Somasundaram C, Bukoski RD, Diz DI. Presence of growth-associated protein 43 and calcium sensing receptor in adventitial neuronal somata (ANNIES) and perivascular nerves of the adult rat mesenteric branch artery [abstract]. Hypertension. 2006;48(4):e71-e72.

Robbins ME, Diz DI. Pathogenic role of the renin-angiotensin system in modulating radiation-induced late effects. Int J Radiat Oncol Biol Phys. 2006;64(1):6-12.

Garcia-Espinosa MA, Vinsant S, Gallagher PE, Ferrario CM, Ganten D, Chappell MC, Diz DI. Regulation of brain neprilysin and ACE2 in transgenic rats during aging [abstract]. Am J Med Sci. 2006;331(2):61.

Kasper SO, Sakima A, Ferrario CM, Ganten D, Diz DI. Altered stress responses in rats with low glial angiotensinogen [abstract]. Am J Med Sci. 2006;331(2):63.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Surgical Sciences-Hypertension

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