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Debra I. Diz, Ph.D.Wake Forest School of Medicine

Debra I. Diz, Ph.D.


Contact Information

Academic: 336-716-2150 | Department: 336-716-2150


Education & Training

  • B.A., Randolph-Macon Womans College, 1976
  • Ph.D., University of Tennessee-Memphis, 1980
  • Fellowship, National Institutes Hlth, 1983


  • Western Nc Chpt Soc For Neuros
  • Am Heart Association
  • Am Physiological Society
  • Am Soc for Pharm & Exper Ther
  • Cons for SE Hypertension Contr
  • Council For High Blood Pressur
  • Inter-Amer Soc of Hypertension
Debra I. Diz, Ph.D.

Debra I. Diz, Ph.D.

Director, Hypertension and Vascular Research Center
Professor, Hypertension
Center on Diabetes, Obesity, and Metabolism
Office of Women in Medicine and Science

Research Interests

Baroreflex; Angiotensin I; Peptide Fragments; Solitary Nucleus; Renin-Angiotensin System
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Contact Information

Academic: 336-716-2150 | Department: 336-716-2150


Recent Publications

Antenatal corticosteroids and the renin-angiotensin-aldosterone system in adolescents born preterm. South AM, Nixon PA, Chappell MC, Diz DI, Russell GB, Snively BM, Shaltout HA, Rose JC, O'Shea TM, Washburn LK.. Pediatr Res. 2017;81(1):88-93.

Angiotensin-(1-7)-dependent vasorelaxation of the renal artery exhibits unique angiotensin and bradykinin receptor selectivity. Yousif MH, Benter IF, Diz DI, Chappell MC.. Peptides. 2017;90():10-16.

No brain renin-angiotensin system: deja vu all over again? [editorial]. Sigmund CD, Diz DI, Chappell MC.. Hypertension. 2017;69(6):1007-1010.

Effects of supervised exercise and dietary nitrate in older adults with controlled hypertension and/or heart failure with preserved ejection fraction. Shaltout HA, Eggebeen J, Marsh AP, Brubaker PH, Laurienti PJ, Burdette JH, Basu S, Morgan A, Dos Santos PC, Norris JL, Morgan TM, Miller GD, Rejeski WJ, Hawfield AT, Diz DI, Becton JT, Kim-Shapiro DB, Kitzman DW.. Nitric Oxide. 2017;():.

Why publish in the American journal of Physiology-Heart and Circulatory Physiology? [editorial]. Zucker IH, Lindsey ML, Delmar M, De Windt LJ, Des Rosiers C, Diz DI, Hester RL, Jones SP, Kanagy N, Kitakaze M, Liao R, Lopaschuk GD, Patel KP, Recchia FA, Sadoshima J, Shah AM, Ungvari ZI, Benjamin IJ, Blaustein MP, Charkoudian N,.. Am J Physiol Heart Circ Physiol. 2017;313(2):H221-H223.

Fetal betamethasone exposure markedly attenuates the protein expression of angiotensin converting enzyme 2 but not dipeptidyl peptidase 3 within the brain dorsomedial medulla of adult female sheep [abstract]. Hendricks AS, Shaltout HA, Chappell MC, Diz DI.. FASEB J. 2017;31(1 Suppl):997.6.

Adult males of very low birth weight with antenatal corticosteroid exposure exhibit an enhanced blood pressure response to acute stress [abstract]. Washburn L, Chappell M, Beavers D, Diz D, Jensen E, Nixon P, Shaltout H, South A, Taylor R, Rose J.. FASEB J. 2017;31(1 Suppl):852.8.

Effects of resistance training with and without caloric restriction on arterial stiffness in overweight and obese older adults. Jefferson ME, Nicklas BJ, Chmelo EA, Crotts CI, Shaltout HA, Diz DI, Marsh AP, Brinkley TE.. Am J Hypertens. 2016;29(4):494-500.

Distinct neurohumoral biomarker profiles in children with hemodynamically defined orthostatic intolerance may predict treatment options. Wagoner AL, Shaltout HA, Fortunato JE, Diz DI.. Am J Physiol Heart Circ Physiol. 2016;310(3):H416-H425.

Medullary endocannabinoids contribute to the differential resting baroreflex sensitivity in rats with altered brain renin-angiotensin system expression. Schaich CL, Grabenauer M, Thomas BF, Shaltout HA, Gallagher PE, Howlett AC, Diz DI.. Front Physiol. 2016;7():207.

Sex specific differences in key signaling pathways involved in sympathetic nervous system control within the dorsal medulla of adult sheep with fetal betamethasone exposure [abstract]. Hendricks AS, Diz DI, Shaltout HA, Chappell MC.. FASEB J. 2016;30(1 Suppl):716.5.

Beneficial cardiovascular effects of muscadine grape extract in normotensive female rats [abstract]. Duncan AV, Shaltout HA, Tommasi EN, Gallagher PE, Tallant EA, Diz DI.. FASEB J. 2016;30(1 Suppl):1175.7.

Deletion of proton-sensing receptor GPR4 associates with lower blood pressure and lower binding of angiotensin II receptor in SFO. Sun X, Tommasi E, Molina D, Sah R, Brosnihan KB, Diz DI, Petrovic S.. Am J Physiol Renal Physiol. 2016;311(6):F1260-1266.

Influence of race and obesity on the renin-angiotensin-aldosterone system in adolescents born preterm [abstract]. South AM, Nixon PA, Chappell MC, Diz DI, Russell GB, Snively BM, Shaltout HA, Rose JC, O'Shea TM, Washburn LK.. Hypertension. 2016;68(Suppl 1):A136.

Antenatal corticosteroids and alterations in renal function in adolescents born preterm [abstract]. South AM, Nixon PA, Chappell MC, Diz DI, Russell GB, Snively BM, Shaltout HA, Rose JC, O'Shea TM, Washburn LK.. Hypertension. 2016;68(Suppl 1):AP121.

The renin-angiotensin-aldosterone system in adolescent offspring born prematurely to mothers with preeclampsia. Washburn LK, Brosnihan KB, Chappell MC, Diz DI, Gwathmey TM, Nixon PA, Russell GB, Snively BM, O'Shea TM.. J Renin Angiotensin Aldosterone Syst. 2015;16(3):529-538.

Mechanisms of human erythrocytic bioactivation of nitrite. Liu C, Wajih N, Liu X, Basu S, Janes J, Marvel M, Keggi C, Helms CC, Lee AN, Belanger AM, Diz DI, Laurienti PJ, Caudell DL, Wang J, Gladwin MT, Kim-Shapiro DB.. J Biol Chem. 2015;290(2):1281-1294.

Alterations in the medullary endocannabinoid system contribute to age-related impairment of baroreflex sensitivity. Schaich CL, Shaltout HA, Grabenauer M, Thomas BF, Gallagher PE, Howlett AC, Diz DI.. J Cardiovasc Pharmacol. 2015;65(5):473-479.

Intracerebroventricular infusion of angiotensin-(1-7) improves baroreflex sensitivity in antenatal betamethasone exposed sheep [abstract]. Lawson MJ, Figueroa JP, Rose JC, Chappell MC, Diz DI, Shaltout HA.. FASEB J. 2015;29(1 Suppl):811.30.

Obesity induces further autonomic impairment in sheep exposed antenatally to betamethasone [abstract]. Lawson MJ, Shaltout HA, Chappell MC, Diz DI, Figueroa JP.. FASEB J. 2015;29(1 Suppl):LB724.

Injury patterns associated with hypotension in pediatric trauma patients: a national trauma database review. Gardner AR, Diz DI, Tooze JA, Miller CD, Petty J.. J Trauma Acute Care Surg. 2015;78(6):1143-1148.

Galphai/o-dependent Ca(2+) mobilization and Galphaq-dependent PKCalpha regulation of Ca(2+)-sensing receptor-mediated responses in N18TG2 neuroblastoma cells. Sesay JS, Gyapong RN, Najafi LT, Kabler SL, Diz DI, Howlett AC, Awumey EM.. Neurochem Int. 2015;90():142-151.

Distinct profiles of brain medullary metabolites detected by 1H-magnetic resonance spectroscopy correlate with indices of autonomic function and visceral fat in healthy adults [abstract]. Diz DI, Olson J, Bourland JD, Kitzman D, Carr JJ, Kritchevsky SB, Groban L, Shaltout HA.. Hypertension. 2015;66(Suppl 1):AP149.

Angiotensin II - endocannabinoid interactions in the nucleus of the solitary tract are important for regulation of baroreflex control of heart rate [abstract]. Diz DI, Tommasi EN, Howlett AC, Shaltout HA.. Hypertension. 2015;66(Suppl 1):AP189.

Intracerebroventricular (ICV) infusion of angiotensin-(1-7) lowers blood pressure and improves autonomic function in antenatal betamethasone exposed sheep [abstract]. Lawson MJ, Figueroa JP, Chappell MC, Diz DI, Shaltout HA.. Hypertension. 2015;66(Suppl 1):A081.

1H-magnetic resonance spectroscopy reveals elevation of myoInositol and other markers of inflammation in the dorsal medulla of children with orthostatic intolerance [abstract]. Wagoner AL, Olson JD, Fortunato JE, Diz DI, Shaltout HA.. Hypertension. 2015;66(Suppl 1):AP069.

Update on the angiotensin converting enzyme 2-angiotensin (1-7)-Mas receptor axis: fetal programing, sex differences, and intracellular pathways. Chappell MC, Marshall AC, Alzayadneh EM, Shaltout HA, Diz DI.. Front Endocrinol (Lausanne). 2014;4():201.

Enhanced activity of an angiotensin-(1-7) neuropeptidase in glucocorticoid-induced fetal programming. Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC.. Peptides. 2014;52():74-81.

Evidence for an angiotensin-(1-7) neuropeptidase expressed in the brain medulla and CSF of sheep. Marshall AC, Pirro NT, Rose JC, Diz DI, Chappell MC.. J Neurochem. 2014;130(2):313-323.

Relationship among nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained nausea. Tarbell SE, Shaltout HA, Wagoner AL, Diz DI, Fortunato JE.. Exp Brain Res. 2014;232(8):2645-2650.

The metabolic challenge induced by hypercaloric diet leads to increased activity of the HPA axis and cardiac autonomic dysfunction in rats with low glial angiotensinogen [abstract]. de Lima DC, Nascimento K, Shaltout HA, Coimbra CC, Diz DI.. FASEB J. 2014;28(1 Suppl):831.3.

Evidence for an angiotensin-(1-7) neuropeptidase in the brain medulla of sheep [abstract]. Marshall A, Pirro N, Rose J, Diz D, Chappell M.. FASEB J. 2014;28(1 Suppl):1140.6.

Effect of fludrocortisone acetate on chronic unexplained nausea and abdominal pain in children with orthostatic intolerance. Fortunato JE, Wagoner AL, Harbinson RL, D'Agostino RB Jr, Shaltout HA, Diz DI.. J Pediatr Gastroenterol Nutr. 2014;59(1):39-43.

Blockade of CB1 receptors reveals that elevated medullary endocannabinoids contribute to age-related impairment of baroreflex sensitivity in Sprague-Dawley rats [abstract]. Schaich C, Thomas B, Grabenauer M, Howlett A, Diz D.. FASEB J. 2014;28(1 Suppl):681.4.

Differential blood pressure response in normotensive rats and rats with angiotensin II-dependent hypertension following systemic cannabinoid CB1 receptor blockade [abstract]. Schaich C, Howlett A, Brosnihan K, Diz D.. FASEB J. 2014;28(1 Suppl):1140.11.

Acute and chronic systemic CB1 cannabinoid receptor blockade improves blood pressure regulation and metabolic profile in hypertensive (mRen2)27 rats. Schaich CL, Shaltout HA, Brosnihan KB, Howlett AC, Diz DI.. Physiol Rep. 2014;2(8):e12108.

Endogenous leptin contributes to baroreflex suppression within the solitary tract nucleus of aged rats. Arnold AC, Diz DI.. Am J Physiol Heart Circ Physiol. 2014;307(11):H1539-1546.

Effects of a community-based weight loss intervention on adipose tissue circulating factors. Miller GD, Isom S, Morgan TM, Vitolins MZ, Blackwell C, Brosnihan KB, Diz DI, Katula J, Goff D.. Diabetes Metab Syndr. 2014;8(4):205-211.

Impaired hemodynamic response to head up tilt in adolescents presenting with chronic nausea and orthostatic intolerance [abstract]. Shaltout HA, Wagoner AL, Fortunato JE, Diz DI.. Hypertension. 2014;64(Suppl 1):A513.

Novel neurohumoral responses to head upright tilt testing in children with chronic nausea and orthostatic intolerance [abstract]. Wagoner AL, Shaltout HA, Diz DI, Fortunato JE.. Hypertension. 2014;64(Suppl 1):A033.

Effect of adding beet root juice to exercise on physical performance and cardiovascular measures in old hypertensive subjects [abstract]. Shaltout HA, Marsh AP, Laurienti P, Basu S, Klebous CC, Kus N, Morgan A, DosSantos PC, Norris JL, Miller G, Rejeski J, Hawfield AT, Diz DI, Kim-Shapiro DB.. Hypertension. 2014;64(Suppl 1):A462.

Another chapter in the understanding of angiotensin-catecholamine interactions relevant to blood pressure control. Diz DI.. Exp Physiol. 2014;99(12):1595-1596.

Brain renin-angiotensin system in the nexus of hypertension and aging. Arnold AC, Gallagher PE, Diz DI.. Hypertens Res. 2013;36(1):5-13.

The brain renin-angiotensin system and mitochondrial function: influence on blood pressure and baroreflex in transgenic rat strains. Nautiyal M, Arnold AC, Chappell MC, Diz DI.. Int J Hypertens. 2013;2013():136028.

Response to angiotensin-(1-7) and bradykinin in baroreceptor reflex sensitivity in hypertension [letter]. Nautiyal M, Shaltout HA, de Lima DC, do Nascimento K, Chappell MC, Diz DI.. Hypertension. 2013;61(2):e20.

Fetal betamethasone exposure attenuates angiotensin-(1-7)-Mas receptor expression in the dorsal medulla of adult sheep. Marshall AC, Shaltout HA, Nautiyal M, Rose JC, Chappell MC, Diz DI.. Peptides. 2013;44(C):25-31.

AT1, AT2, and AT1-7 receptor expression in the uteroplacental unit of normotensive and hypertensive rats during early and late pregnancy. Yamaleyeva LM, Neves LA, Coveleskie K, Diz DI, Gallagher PE, Brosnihan KB.. Placenta. 2013;34(6):497-502.

Differential expression of renin-angiotensin system components in the choroid plexus of betamethasone exposed and control sheep [abstract]. Marshall AC, Shaltout HA, Pirro NT, Rose JC, Diz DI, Chappell MC.. FASEB J. 2013;27(Meeting Abstracts):1107.12.

Reduction in central mitochondrial ROS improves cardiovagal baroreflex function independent of blood pressure in (mRen2)27 rats [abstract]. Nautiyal M, Shaltout HA, Chappell MC, Diz DI.. FASEB J. 2013;27(Meeting Abstracts):890.4.

Increased constrictor tone induced by ouabain treatment in rats. Pulgar VM, Jeffers AB, Rashad HM, Diz DI, Aileru AA.. J Cardiovasc Pharmacol. 2013;62(2):174-183.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Hypertension

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