Iris J. Edwards, Ph.D., Associate Professor Pathology-Tumor Biology

Iris J. Edwards, Ph.D.

Associate Professor, Pathology-Tumor Biology
Comprehensive Cancer Center
Women's Health Center of Excellence for Research, Leadership, Education
Center for Integrative Medicine

Contact Information

Academic: 336-716-2677 | Department: 336-716-2677

Email: iedwards@wakehealth.edu

Education & Training

B.A., High Point University , 1984
Ph.D., Wake Forest University , 1989

Memberships

Am Assn for the Adv of Science
Am Heart Association
Am Soc Of Biochem & Mol Biolog
Am Soc Of Cell Biology

Iris J. Edwards, Ph.D.

Associate Professor, Pathology-Tumor Biology Comprehensive Cancer Center
Women's Health Center of Excellence for Research, Leadership, Education
Center for Integrative Medicine

Research Interests

cancer/oncogenesis, cell growth, differentiation,d, molecular biology/molecular me, nutrition, women's health issues

Contact Information

Academic: 336-716-2677 | Department: 336-716-2677

Email: iedwards@wakehealth.edu

Recent Publications

Hu Y, Sun H, O'Flaherty JT, Edwards IJ. 15-Lipoxygenase-1-mediated metabolism of docosahexaenoic acid is required for syndecan-1 signaling and apoptosis in prostate cancer cells. Carcinogenesis. 2013;34(1):176-182.

Wang S, Wu J, Suburu J, Gu Z, Cai J, Axanova LS, Cramer SD, Thomas MJ, Perry DL, Edwards IJ, Mucci LA, Sinnott JA, Loda MF, Sui G, Berquin IM, Chen YQ. Effect of dietary polyunsaturated fatty acids on castration-resistant Pten-null prostate cancer. Carcinogenesis. 2012;33(2):404-412.

Edwards IJ. Proteoglycans in prostate cancer. Nat Rev Urol. 2012;9(4):196-206.

O'Flaherty JT, Hu Y, Wooten RE [deceased], Horita DA, Samuel MP, Thomas MJ, Sun H, Edwards IJ. 15-Lipoxygenase metabolites of docosahexaenoic acid inhibit prostate cancer cell proliferation and survival. PLoS One. 2012;7(9):e45480.

Sun H, Hu Y, Gu Z, Wilson MD, Chen YQ, Rudel LL, Willingham MC, Edwards IJ. Endogenous synthesis of n-3 polyunsaturated fatty acids in fat-1 mice is associated with increased mammary gland and liver syndecan-1. PLoS ONE. 2011;6(5):e20502.

Sun H, Hu Y, Gu Z, Owens RT, Chen YQ, Edwards IJ. Omega-3 fatty acids induce apoptosis in human breast cancer cells and mouse mammary tissue through syndecan-1 inhibition of the MEK-Erk pathway. Carcinogenesis. 2011;32(10):1518-1524.

Berquin IM, Edwards IJ, Kridel SJ, Chen YQ. Polyunsaturated fatty acid metabolism in prostate cancer. Cancer Metastasis Rev. 2011;30(3-4):295-309.

Berquin IM, Edwards IJ, O'Flaherty JT, Chen YQ.Omega-3 PUFAs: interventional trials for the prevention and treatment of breast and prostate cancer

Edwards IJ, Berquin IM, Chen YQ, O'Flaherty JT.Omega-3 PUFAs, breast and prostate cancer: experimental studies

Hu Y, Sun H, Owens RT, Gu Z, Wu J, Chen YQ, O'Flaherty JT, Edwards IJ. Syndecan-1-dependent suppression of PDK1/Akt/bad signaling by docosahexaenoic acid induces apoptosis in prostate cancer. Neoplasia. 2010;12(10):826-836.

Hu Y, Sun H, Owens RT, Wu J, Chen YQ, Berquin IM, Perry D, O'Flaherty JT, Edwards IJ. Decorin suppresses prostate tumor growth through inhibition of epidermal growth factor and androgen receptor pathways. Neoplasia. 2009;11(10):1042-1053.

Sun H, Berquin IM, Owens RT, O'Flaherty JT, Edwards IJ. Peroxisome proliferator-activated receptor gamma-mediated up-regulation of syndecan-1 by n-3 fatty acids promotes apoptosis of human breast cancer cells. Cancer Res. 2008;68(8):2912-2919.

Edwards IJ, Sun H, Hu Y, Berquin IM, O'Flaherty JT, Cline JM, Rudel LL, Chen YQ. In vivo and in vitro regulation of syndecan 1 in prostate cells by n-3 polyunsaturated fatty acids. J Biol Chem. 2008;283(26):18441-9.

Edwards IJ, O'Flaherty JT. Omega-3 fatty acids and PPARgamma in cancer. PPAR Res. 2008;2008():A358052.

Berquin IM, Edwards IJ, Chen YQ. Multi-targeted therapy of cancer by omega-3 fatty acids. Cancer Lett. 2008;269(2):363-377.

Berquin IM, Min Y, Wu R, Wu J, Perry D, Cline JM, Thomas MJ, Thornburg T, Kulik G, Edwards IJ, D'Agostino R Jr, Chen YQ, et al. Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids. J Clin Invest. 2007;117(7):1866-1875.

Chen YQ, Edwards IJ, Kridel SJ, Thornburg T, Berquin IM. Dietary fat-gene interactions in cancer. Cancer Metastasis Rev. 2007;26(3-4):535-551.

Chen YQ, Berquin IM, Daniel LW, Edwards IJ, O'Flaherty JT, Thomas MJ, Tooze JA, Wykle B. Omega-3 fatty acids and cancer risk [letter]. JAMA. 2006;296(3):282.