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James C. Eisenach, M.D.Wake Forest School of Medicine

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James C. Eisenach, M.D.

Professor,



Clinical Specialties

Obstetrical Anesthesia, Pain Research

Contact Information

Department: 336-716-2011

Email: eisenach@wakehealth.edu

Insurance Accepted »

Education & Training

  • B.A., University of Nebraska-Lincoln , 1976
  • M.S., California Institute of Technology , 1978
  • M.D., University of California Sch of Med-SanFrancisco , 1982
  • Internship, Medicine, Mount Zion Hosp & Med Ctr, 1983
  • Residency, Anesthesiology, Mayo Clinic, 1985
  • Fellowship, WFU School of Medicine, 1986

Board Certifications

  • American Board of Anesthesiology, Anesthesiology - Anesthesiology

Memberships

  • Am Medical Assn
  • Am Pain Society
  • Am Soc Of Anesthesiologists
  • Am Soc Of Clinical Oncology
  • Am Soc Of Mass Spectrometry
  • Assn Of University Anesthesiol
  • Col.Of Chest Physicians
  • Cons for SE Hypertension Contr
  • Int'l Anesthesia Research Soci
  • Int'l Assn For The Study Of Pa

NPI Number

  • 1932184801
James C. Eisenach, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

James C. Eisenach, M.D.

Professor, Obstetrical and Gynecological Anesthesiology
Office of Women in Medicine and Science
Physiology & Pharmacology
Translational Science Institute

Research Interests

anesthesiology, pain, prevention, surgery/trauma/burns/trauma, women's health issues

Contact Information

Academic: 336-716-4182 | Department: 336-716-2011

Email: eisenach@wakehealth.edu

Recent Publications

Eisenach JC, Rathmell JP. Complexities of basic science [reply to letter]. Anesthesiology. 2014;120(1):238-239.


Yaksh TL, Hobo S, Peters C, Osborn KG, Richter PJ Jr, Rossi SS, Grafe MR, Eisenach JC. Preclinical toxicity screening of intrathecal oxytocin in rats and dogs. Anesthesiology. 2014;120(4):951-961.

Peters CM, Ririe D, Houle TT, Aschenbrenner CA, Eisenach JC. Nociceptor-selective peripheral nerve block induces delayed mechanical hypersensitivity and neurotoxicity in rats. Anesthesiology. 2014;120(4):976-986.

Street LM, Matheson D, Mill MP [sic] [Mills MP], Nitsche JF, Pinyan CW, Eisenach J. Snoring frequency increases during pregnancy and is associated with hypertension and cesarean delivery for labor dystocia [abstract]. In: Abstracts of the 2014 Annual Meeting of the American Society of Anesthesiologists (ASA); 2014 May 14-18; Toronto, Ontario Canada. 2014;():374.

Lombardo S, Peters C, Eisenach J. The effects of nerve injury on the expression of vasopressin receptor V1aR in the dorsal root ganglia [abstract]. J Pain. 2014;15(4 Suppl 1):S48.


Pan PH, Eisenach JC. The pain of childbirth and its effect on the mother and the fetus In: Chestnut DH, Wong CA, Tsen LC, Ngan Kee WD, Beilin Y, Mhyre JM, Nathan N, eds. Chestnut's obstetric anesthesia: principles and practice. 5th ed. Philadelphia: Elsevier;2014: 410-426.

Eisenach JC, Houle TT. Replication to advance science: changes in ANESTHESIOLOGY [editorial]. Anesthesiology. 2014;121(2):209-211.

Aschenbrenner CA, Houle TT, Gutierrez S, Eisenach JC. Modeling individual recovery after peripheral nerve injury in rats and the effects of parturition. Anesthesiology. 2014;():.

Gutierrez S, Hayashida K, Eisenach JC. The puerperium alters spinal cord plasticity following peripheral nerve injury. Neuroscience. 2013;228():301-308.

Kimura M, Hayashida K, Eisenach JC, Saito S, Obata H. Relief of hypersensitivity after nerve injury from systemic donepezil involves spinal cholinergic and gamma-aminobutyric acid mechanisms. Anesthesiology. 2013;118(1):173-180.

Gutierrez S, Liu B, Hayashida K, Houle TT, Eisenach JC. Reversal of peripheral nerve injury-induced hypersensitivity in the postpartum period: role of spinal oxytocin. Anesthesiology. 2013;118(1):152-159.

Eisenach JC, Pan P, Smiley RM, Lavand'homme P, Landau R, Houle TT. Resolution of pain after childbirth. Anesthesiology. 2013;118(1):143-151.

Eisenach JC. Case reports are leaving Anesthesiology, but not the specialty [editorial]. Anesthesiology. 2013;118(3):479-480.

Pan PH, Tonidandel AM, Aschenbrenner CA, Houle TT, Harris LC, Eisenach JC. Predicting acute pain after cesarean delivery using three simple questions. Anesthesiology. 2013;118(5):1170-1179.

Turner D, Miller S, Aschenbrenner C, Houle T, Eisenach J. Predicting pain after joint surgery [abstract]. J Pain. 2013;14(4 Suppl 1):S15.



Wells RE, Burch R, Paulsen R, Wayne P, Aschenbrenner C, Houle TT, Eisenach JC, Loder E. Meditation for migraines: a pilot randomized controlled trial [abstract]. Cephalalgia. 2013;33(8 Suppl):96-97.

Hayashida K-i, Peters CM, Gutierrez S, Eisenach JC. Depletion of endogenous noradrenaline does not prevent spinal cord plasticity following peripheral nerve injury. J Pain. 2012;13(1):49-57.



Turner DP, Smitherman TA, Eisenach JC, Penzien DB, Houle TT. Predictors of headache before, during, and after pregnancy: a cohort study. Headache. 2012;52(3):348-362.

Martucci K, Eisenach J, North J, Rauck R, Tong C, Wilson K, Coghill R. Offset analgesia in complex regional pain syndrome [abstract]. J Pain. 2012;13(4 Suppl):S47.

Devereaux PJ, Chan MTV, Eisenach J, Schricker T, Sessler DI. The need for large clinical studies in perioperative medicine [editorial]. Anesthesiology. 2012;116(6):1169-1175.

Martucci KT, Eisenach JC, Tong C, Coghill RC. Opioid-independent mechanisms supporting offset analgesia and temporal sharpening of nociceptive information. Pain. 2012;153(6):1232-1243.


Hayashida K-i, Kimura M, Yoshizumi M, Hobo S, Obata H, Eisenach JC. Ondansetron reverses antihypersensitivity from clonidine in rats after peripheral nerve injury: role of gamma-aminobutyric acid in alpha2-adrenoceptor and 5-HT3 serotonin receptor analgesia. Anesthesiology. 2012;117(2):389-398.


Boada MD, Gutierrez S, Giffear K, Eisenach JC, Ririe DG. Skin incision-induced receptive field responses of mechanosensitive peripheral neurons are developmentally regulated in the rat. J Neurophysiol. 2012;108(4):1122-1129.

Eisenach JC. It's a bright and sunny day: anesthesiology in 2011 [editorial]. Anesthesiology. 2011;114(1):24.


Eisenach JC. Note of editorial concern [editorial]. Anesthesiology. 2011;115(3):463.




Hains LE, Loram LC, Taylor FR, Strand KA, Wieseler JL, Barrientos RM, Young JJ, Frank MG, Sobesky J, Martin TJ, Eisenach JC, Maier SF, Johnson JD, Fleshner M, Watkins LR. Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors. J Neuroimmunol. 2011;239(1-2):53-60.

Booth JL, Harris L, Fish R, Pan P, Eisenach J. Improving pain relief for those who need it most after cesarean delivery [abstract]. In: Abstracts of the 2011 Annual Meeting of the American Society of Anesthesiologists (ASA); 2011 Oct 15-19; Chicago (IL). 2011;():A432.

Ririe DG, Boada DM, Martin TJ, Boyden ES, Eisenach JC. Optical inhibition of neurons in whole rat dorsal root ganglion after in vivo intrathecal viral vector induced expression of the optically active proton pump Arch-T [abstract]. In: Abstracts of the 2011 Annual Meeting of the American Society of Anesthesiologists (ASA); 2011 Oct 15-19; Chicago (IL). 2011;():A391.

Eisenach JC. Washington University and the why of anesthesiology [editorial]. Anesthesiology. 2011;115(6):1145-1146.



Yaksh TL, Eisenach JC, Shafer SL. Consent contraindicated? [letter]. Science. 2010;328(5974):45.

Eisenach JC. To our readers: an experiment in education [editorial]. Anesthesiology. 2010;112(1):1-2.


Eisenach JC, Curry R, Tong C, Houle TT, Yaksh TL. Effects of intrathecal ketorolac on human experimental pain. Anesthesiology. 2010;112(5):1216-1224.

Eisenach JC, Curry R, Rauck R, Pan P, Yaksh TL. Role of spinal cyclooxygenase in human postoperative and chronic pain. Anesthesiology. 2010;112(5):1225-1233.

Eisenach JC, Sumikawa K, Makita T, Cho S. Anesthesiology and the Japanese Society of Anesthesiologists: the science is amazing [editorial]. Anesthesiology. 2010;112(6):1301-1302.


Martucci K, Eisenach J, Tong C, Coghill R. Early and delayed effects of intravenous administration of remifentanil and naloxone on sensitivity to thermal stimuli [abstract]. J Pain. 2010;11(4 Suppl 1):S31.


Peters CM, Hayashida K-i, Ewan EE, Nakajima K, Obata H, Xu Q, Yaksh TL, Eisenach JC. Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat. Brain Res. 2010;1352():83-93.

Hains LE, Loram LC, Weiseler JL, Frank MG, Bloss EB, Sholar P, Taylor FR, Harrison JA, Martin TJ, Eisenach JC, et al. Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming. J Pain. 2010;11(10):1004-1014.

Turner DP, Houle TT, Eisenach JC, Pan PH. Peripartum experience of problem headache sufferers [abstract]. Headache. 2010;50(Suppl 1):S21.

Eisenach JC. Why is Karolinska on the cover of an American journal? [editorial]. Anesthesiology. 2010;113(6):1257.

Boada MD, Houle TT, Eisenach JC, Ririe DG. Differing neurophysiologic mechanosensory input from glabrous and hairy skin in juvenile rats. J Neurophysiol. 2010;104(6):3568-3575.

Martucci KT, Eisenach JC, Tong C, Coghill RC. Paradoxical increases in offset analgesia during acute opioid induced hypersensitivity [abstract]. In: Abstracts of the 13th World Congress on Pain; 2010 Aug 29 - Sept 2; Montreal, Quebec (Canada). 2010;():abstr 225.

Eisenach JC, Shafer SL, Pollard BJ. Reply to Fospropofol assay: issues and impact on pharmacokinetic and pharmacodynamic evaluation [reply to letter]. Eur J Anaesthesiol. 2009;26(1):81-82.

Eisenach JC, Shafer SL, Pollard BJ. Fospropofol assay issues and impact on pharmacokinetic and pharmacodynamic evaluation [reply to letter]. Anesth Analg. 2009;108(1):382-383.



Eisenach JC. Curiosity, discipline, and joy; and the greatest of these is joy [editorial]. Anesthesiology. 2009;110(4):712-713.

Pan PH, Eisenach JC. The pain of childbirth and its effect on the mother and the fetus In: Chestnut DH, Polley LS, Tsen LC, Wong CA, eds. Chestnut's obstetric anesthesia: principles and practice. 4th ed. Philadelphia: Mosby/Elsevier;2009: 387-404.


Ross VH, Pan PH, Owen MD, Seid MH, Harris L, Clyne B, Voltaire M, Eisenach JC. Neostigmine decreases bupivacaine use by patient-controlled epidural analgesia during labor: a randomized controlled study. Anesth Analg. 2009;109(2):524-531.

Martucci KT, Eisenach JC, Tong C, Coghill RC. Comparison of heat hyperalgesia following intravenous administration of naloxone and remifentanil [abstract]. Soc Neurosci Abstr. 2009;2009(Neuroscience Meeting Planner):.

Eisenach JC. Are signposts in the woods pointing in the right direction? [reply to letter]. Anesthesiology. 2009;111(5):1167.

Pan PH, Paitsel B, Eisenach J. Is CSF oxytocin concentration different between immediate postpartum and non-peripartum patients? [abstract]. In: Abstracts of the 2009 Annual Meeting of the American Society of Anesthesiologists (ASA); 2009 Oct 17-21; New Orleans (LA). 2009;():A859.

Fisher DM, Eisenach JC. Science marches forward: a new tool to study the progress of labor [editorial]. Anesthesiology. 2009;111(5):936-937.

Borgeat A, Brennan TJ, Eisenach JC, Hemmings HC Jr, Isono S, Kersten JR, Kochs E, Riou B, Warner DS. 2009 in review: advancing medicine in anesthesiology. Anesthesiology. 2009;111(6):1192-1196.

Eisenach JC. To our authors [editorial]. Anesthesiology. 2009;111(6):1189-1191.

Houle TT, Eisenach JC. The need for perspective [reply to letter]. Anesthesiology. 2009;111(6):1386-1387.

Eisenach JC, Borgeat A, Bosnjak J, Brennan TJ, Kersten JR, Kochs EF, Wiener-Kronish JP. 2007 in review: a dozen steps forward in anesthesiology. Anesthesiology. 2008;108(1):149-155.

Yaksh TL, Tozier N, Horais KA, Malkmus S, Rathbun M, LaFranco L, Eisenach J. Toxicology profile of N-methyl-D-aspartate antagonists delivered by intrathecal infusion in the canine model. Anesthesiology. 2008;108(5):938-949.

Liu B, Tong C, Eisenach JC. Pregnancy increases excitability of mechanosensitive afferents innervating the uterine cervix. Anesthesiology. 2008;108(6):1087-1092.

Tong C, Conklin DR, Liu B, Ririe DG, Eisenach JC. Assessment of behavior during labor in rats and effect of intrathecal morphine. Anesthesiology. 2008;108(6):1081-1086.


Ririe DG, Liu B, Clayton B, Tong C, Eisenach JC. Electrophysiologic characteristics of large neurons in dorsal root ganglia during development and after hind paw incision in the rat. Anesthesiology. 2008;109(1):111-117.

Eisenach JC, Kersten J. Science and the mission of Anesthesiology [editorial]. Anesthesiology. 2008;109(1):1-2.

Eisenach JC. Anesthesiology, its mission, and 2007's 'best' articles [reply to letter]. Anesthesiology. 2008;109(1):158.


Lerman J, Kharasch ED, Eisenach JC, Warner MA, Jevtovic-Todorovic V, Patel PM, Sun LS. Journal-related and other special activities at the 2008 American Society of Anesthesiologists Annual Meeting. Anesthesiology. 2008;109(3):365-370.

Eisenach JC, Pan PH, Smiley R, Lavand-homme P, Landau R, Houle TT. Severity of acute pain after childbirth, but not type of delivery, predicts persistent pain and postpartum depression. Pain. 2008;140(1):87-94.

Hayashida K, Eisenach JC. Multiplicative interactions to enhance gabapentin to treat neuropathic pain. Eur J Pharmacol. 2008;598(1-3):21-26.

Eisenach JC, Shafer SL, Pollard BJ. Fospropofol assay issues and impact on pharmacokinetic and pharmacodynamic evaluation [reply to letter]. Anesthesiology. 2008;109(5):937.

Rice ASC, Cimino-Brown D, Eisenach JC, Kontinen VK, Lacroix-Fralish ML, Machin I, Mogil JS, Stohr T. Animal models and the prediction of efficacy in clinical trials of analgesic drugs: a critical appraisal and call for uniform reporting standards. Pain. 2008;139(2):243-247.

Tonidandel AM, Pan PH, Eisenach JC, Houle TT, Harris L. A simple model for predicting postcesarean section pain and analgesic requirement [abstract]. Anesthesiology. 2008;109():Abstr 578.

Eisenach JC, Borgeat A, Bosnjak ZJ, Brennan TJ, Kersten JR, Kochs E, Lerman J, Warner DS, Wiener-Kronish JP. 2008 in review: advancing medicine in anesthesiology. Anesthesiology. 2008;109(6):962-972.

Hayashida K-i, Obata H, Nakajima K, Eisenach JC. Gabapentin acts within the locus coeruleus to alleviate neuropathic pain. Anesthesiology. 2008;109(6):1077-1084.

Oshiro Y, Jordan SB, Sintay BJ, Eisenach JC, Coghill RC. Psychophysical differences between mechanical pressure pain and heat pain [abstract]. In: Abstracts of the 12th World Congress on Pain [on CD]. 2008;():PM 266.


Eisenach JC. Can you imagine that? Progress in communication in medicine [editorial]. Anesthesiology. 2007;106(1):3-4.

Martin TJ, Kim SA, Buechler NL, Porreca F, Eisenach JC. Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics. Anesthesiology. 2007;106(2):312-322.

Romero-Sandoval A, Bynum T, Eisenach JC. Analgesia induced by perineural clonidine is enhanced in persistent neuritis. Neuroreport. 2007;18(1):67-71.

Hayashida K, DeGoes S, Curry R, Eisenach JC. Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery. Anesthesiology. 2007;106(3):557-562.



Clayton BA, Hayashida K-i, Childers SR, Xiao R, Eisenach JC. Oral donepezil reduces hypersensitivity after nerve injury by a spinal muscarinic receptor mechanism. Anesthesiology. 2007;106(5):1019-1025.

Landau R, Lavand'Homme P, Houle T, Smiley R, Harris L, Pan PH, Eisenach J. Predictive factors for acute pain after vaginal and cesarean deliveries [abstract]. Anesthesiology. 2007;106(5 Suppl 1):22.

Lee SC, Pan PH, Mertz H, Smith JG, Grondin L, Harris LC, Eisenach J. Effect of spinal versus epidural analgesia on uterine cervical dilation and cytokine expression in laboring women [abstract]. Anesthesiology. 2007;106(5 Suppl 1):9.

Pan PH, Smiley R, Houle T, Landau R, Lavand'Homme P, Harris L, Eisenach J. Predictive factors for chronic pain at 8 weeks after vaginal or cesarean deliveries [abstract]. Anesthesiology. 2007;106(5 Suppl 1):75.


Pan PH, Smiley R, Houle T, Landau R, Lavand'Homme P, Harris L, Eisenach J. Chronic pain after delivery--is it different between vaginal and operative deliveries? [abstract]. Anesthesiology. 2007;106(Suppl 1):22.

Eisenach JC, Brennan TJ. Anesthesiology and the press [editorial]. Anesthesiology. 2007;107(1):8.


Tong C, Conklin DR, Liu B, Ririe DG, Eisenach JC. Assessment of labor pain in rats: an experimental behavioral approach [abstract]. Anesthesiology. 2007;107():Abstr 1202.

Pan PH, Smiley R, Lavand'Homme P, Houle T, Eisenach J. Predictive factors for chronic pain at 8 weeks after vaginal or cesarean deliveries [abstract]. Anesthesiology. 2007;107():Abstr 1203.

Pan PH, Smiley R, Lavand'Homme P, Landau R, Eisenach J. Chronic pain after delivery--is it different between vaginal and operative deliveries? [abstract]. Anesthesiology. 2007;107():Abstr 767.

Liu B, Tong C, Conklin DR, Ririe DG, Eisenach JC. Electrophysiological changes of uterine cervical mechanosensitive afferents during pregnancy [abstract]. Anesthesiology. 2007;107():Abstr 1201.

Landau R, Pan PH, Smiley R, Houle T, Lavand'homme P, Harris L, Eisenach J. Incidence of chronic pain after vaginal or cesarean delivery and predictive factors [abstract]. Swiss Med Wkly. 2007;137(Suppl 160):23S.

Landau R, Pan RH [sic] [Pan PH], Smiley R, Houle T, Lavandhommel R, [Lavand'homme P] Hams L, Eisenach J. Predictive factors of acute pain after delivery [abstract]. Swiss Med Wkly. 2007;137(Suppl 160):23S.


Eisenach JC. Pain: mechanism and activity at the spinal cord. Refresher Courses Anesthesiol. 2007;35():114.


Ririe DG, Clayton BA, Tong C, Eisenach JC. Developmental differences in microglia activation in the spinal cord after paw incision in the rat [abstract]. Anesthesiology. 2006;105():A1374.

Nelson KE, James EC [sic] [Eisenach JC]. CSF concentration does not predict onset or duration of spinal fentanyl for labor analgesia [abstract]. Anesthesiology. 2006;105():A758.



Martin TJ, Eisenach JC, Misler J, Childers SR. Chronic activation of spinal adenosine A1 receptors results in hypersensitivity. Neuroreport. 2006;17(15):1619-1622.

Tong C, Conklin D, Eisenach JC. A pain model after gynecologic surgery: the effect of intrathecal and systemic morphine. Anesth Analg. 2006;103(5):1288-1293.

Obata H, Eisenach JC, Hussain H, Bynum T, Vincler M. Spinal glial activation contributes to postoperative mechanical hypersensitivity in the rat. J Pain. 2006;7(11):816-822.

Martin TJ, Kim SA, Eisenach JC. Clonidine maintains intrathecal self-administration in rats following spinal nerve ligation. Pain. 2006;125(3):257-263.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Obstetrical and Gynecological Anesthesiology

Clinical Specialties

Obstetrical Anesthesia, Pain Research

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