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James C. Eisenach, M.D.Wake Forest School of Medicine

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James C. Eisenach, M.D.

Professor,

Clinical Interests

Obstetrical Anesthesia, Pain Research

Contact Information

Email: eisenach@wakehealth.edu

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Education & Training

  • B.A., University of Nebraska-Lincoln, 1976
  • M.S., California Institute of Technology, 1978
  • M.D., University of California Sch of Med-SanFrancisco, 1982
  • Internship, Medicine, Mount Zion Hosp & Med Ctr, 1983
  • Residency, Anesthesiology, Mayo Clinic, 1985
  • Fellowship, WFU School of Medicine, 1986

Board Certifications

  • American Board of Anesthesiology, Anesthesiology

Memberships

  • Am Medical Assn
  • Am Pain Society
  • Am Soc Of Anesthesiologists
  • Am Soc of Clinical Oncology
  • Am Soc Of Mass Spectrometry
  • Assn Of University Anesthesiol
  • Col.Of Chest Physicians
  • Cons for SE Hypertension Contr
  • Int'l Anesthesia Research Soci
  • Int'l Assn For The Study Of Pa

NPI Number

  • 1932184801
James C. Eisenach, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

James C. Eisenach, M.D.

Professor, Anesthesiology
Office of Women in Medicine and Science

Research Interests

Pain; Spinal Cord; Pain, Postoperative; Anesthesiology; Analgesics
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Contact Information

Academic: 336-716-4182

Email: eisenach@wakehealth.edu

Recent Publications

A randomized controlled trial comparing two multimodal analgesic techniques in patients predicted to have severe pain after cesarean delivery. Booth JL, Harris LC, Eisenach JC, Pan PH.. Anesth Analg. 2016;122(4):1114-1119.

Wherefore gabapentinoids?: Was there rush too soon to judgment? [editorial]. Kharasch ED, Eisenach JC.. Anesthesiology. 2016;124(1):10-12.

Mechanical sensibility of nociceptive and non-nociceptive fast-conducting afferents is modulated by skin temperature. Boada MD, Eisenach JC, Ririe DG.. J Neurophysiol. 2016;115(1):546-553.

Disruption of spinal noradrenergic activation delays recovery of acute incision-induced hypersensitivity and increases spinal glial activation in the rat. Arora V, Morado-Urbina CE, Aschenbrenner CA, Hayashida KI, Wang F, Martin TJ, Eisenach JC, Peters CM.. J Pain. 2016;17(2):190-202.

Reporting of preclinical research in anesthesiology: transparency and enforcement [editorial]. Eisenach JC, Warner DS, Houle TT.. Anesthesiology. 2016;124(4):763-765.

Mindfulness-meditation-based pain relief is not mediated by endogenous opioids. Zeidan F, Adler-Neal AL, Wells RE, Stagnaro E, May LM, Eisenach JC, McHaffie JG, Coghill RC.. J Neurosci. 2016;36(11):3391-3397.

Reporting of observational research in anesthesiology: the importance of the analysis plan [editorial]. Eisenach JC, Kheterpal S, Houle TT.. Anesthesiology. 2016;124(5):998-1000.

Without science there is little art in anesthesiology: 2015 Rovenstine lecture [editorial]. Eisenach JC.. Anesthesiology. 2016;124(6):1205-1207.

Keeping mom awake: does placental location impact fetal disruption of maternal sleep? [abstract]. Street L, Son J, Eisenach J.. Reprod Sci. 2016;23(Suppl 1):103A.

Gestational and postpartum sleep apnea: exhaled nitric oxide as a biomarker in a predictive model [abstract]. Street LM, Aschenbrenner C, Houle T, Pinyan C, Eisenach J.. In: Abstracts of the 2016 Annual Meeting of the American Society of Anesthesiologists (ASA); 2016 May 18-22; Boston (MA). 2016;():GM-04.

Defining the Friedman curve for post-cesarean delivery pain [abstract]. Booth JL, Pan P, Harris LC, Aschenbrenner C, Houle TT, Eisenach JC.. In: Abstracts of the 2016 Annual Meeting of the American Society of Anesthesiologists (ASA); 2016 May 18-22; Boston (MA). 2016;():BP-06.

Mindfulness meditation-induced pain relief does not require endogenous opioidergic systems [abstract]. Adler A, Wells R, Stagnaro E, Barber L, Porter A, Garcia K, Lee D, Kaleita A, Posey G, Cruikshank L, Strittmatter B, Nicolle M, Lichstein P, Eisenach J, McHaffie J, Coghill R, Zeidan F.. J Pain. 2016;17(4 Suppl 1):S112.

Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations. Andrews NA, Latremoliere A, Basbaum AI, Mogil JS, Porreca F, Rice AS, Woolf CJ, Currie GL, Dworkin RH, Eisenach JC, Evans S, Gewandter JS, Gover TD, Handwerker H, Huang W, Iyengar S, Jensen MP, Kennedy JD, Lee N, Levine J, Lidster K, Machin I,.. Pain. 2016;157(4):901-909.

Gabapentin loses efficacy over time after nerve injury in rats: role of glutamate transporter-1 in the locus coeruleus. Kimura M, Eisenach JC, Hayashida KI.. Pain. 2016;157(9):2024-2032.

Mindfulness meditation engages unique, non-opioid mediated mechanisms to reduce pain [abstract]. Zeidan F, Adler A, Wells R, Stagnaro E, Porter AM, Barber L, Lee D, Kaleita A, Garcia K, Posey G, Lichstein P, Eisenach J, McHaffie J, Coghill R.. Psychosom Med. 2016;78(3):A10.

Ethical concerns regarding human study [letter]. Eisenach JC, Yaksh TL.. CNS Neurosci Ther. 2016;22(10):866.

Nerve injury induces a new profile of tactile and mechanical nociceptor input from undamaged peripheral afferents. Boada MD, Gutierrez S, Aschenbrenner CA, Houle TT, Hayashida KI, Ririe DG, Eisenach JC.. J Neurophysiol. 2015;113(1):100-109.

Phase 1 safety assessment of intrathecal oxytocin. Eisenach JC, Tong C, Curry R.. Anesthesiology. 2015;122(2):407-413.

Assessment of attention threshold in rats by titration of visual cue duration during the five choice serial reaction time task. Martin TJ, Grigg A, Kim SA, Ririe DG, Eisenach JC.. J Neurosci Methods. 2015;241():37-43.

Failure of intrathecal ketorolac to reduce remifentanil-induced postinfusion hyperalgesia in humans. Eisenach JC, Tong C, Curry RS.. Pain. 2015;156(1):81-87.

Individual differences in acute pain-induced endogenous analgesia predict time to resolution of postoperative pain in the rat. Peters CM, Hayashida KI, Suto T, Houle TT, Aschenbrenner CA, Martin TJ, Eisenach JC.. Anesthesiology. 2015;122(4):895-907.

Intrathecal clonidine and adenosine: effects on pain and sensory processing in patients with chronic regional pain syndrome. Rauck RL, North J, Eisenach JC.. Pain. 2015;156(1):88-95.

Finding and getting what you want when you want it just got easier at ANESTHESIOLOGY [editorial]. Tedeschi V, Rathmell JP, Eisenach JC.. Anesthesiology. 2015;122(3):491-494.

ANESTHESIOLOGY: attracting the best new science in the specialty [editorial]. Eisenach JC.. Anesthesiology. 2015;122(6):1198-1200.

Down-regulation of astroglial glutamate transporters in the locus coeruleus contributes to impairment of endogenous analgesia in rats after peripheral nerve injury [abstract]. Hayashida K, Kimura M, Peters C, Eisenach J.. J Pain. 2015;16(4 Suppl 1):S50.

Anatomical plasticity in spinal oxytocin fibers after peripheral nerve injury [abstract]. Severino A, Eisenach J.. J Pain. 2015;16(4 Suppl 1):S45.

Science, medicine, and the anesthesiologist: two pages to keep you abreast of key papers from outside the specialty and relevant to your practice [editorial]. Mantz J, Rathmell JP, Eisenach JC.. Anesthesiology. 2015;123(1):1-4.

Modeling recovery from pain following non-emergent cesarean delivery [abstract]. Booth JL, Sharpe EE, Harris LC, Aschenbrenner C, Houle TT, Eisenach JC.. In: Abstracts of the 47th Annual SOAP Meeting; 2015 May 13-17; Colorado Springs (CO). 2015;():25.

A non-opioid adjunct equally or more potent than fentanyl for labor epidural analgesia with less side effects [abstract]. Pan PH, Nelson K, Ross V, Booth J, Harris L, Eisenach J.. In: Abstracts of the 47th Annual SOAP Meeting; 2015 May 13-17; Colorado Springs (CO). 2015;():51.

Recovery of physical activity after cesarean delivery and its relationship with pain [abstract]. Sharpe EE, Booth JL, Harris LC, Aschenbrenner C, Houle TT, Eisenach JC.. In: Abstracts of the 47th Annual SOAP Meeting; 2015 May 13-17; Colorado Springs (CO). 2015;():164.

Impaired pain-evoked analgesia after nerve injury in rats reflects altered glutamate regulation in the locus coeruleus. Kimura M, Suto T, Morado-Urbina CE, Peters CM, Eisenach JC, Hayashida KI.. Anesthesiology. 2015;123(4):899-908.

Modeling recovery from pain following non-emergent cesarean delivery [abstract]. Sharpe EE, Booth JL, Pan PH, Aschenbrenner C, Houle TT, Eisenach JC, Harris L.. In: Abstracts of the 2015 Annual Meeting of the American Society of Anesthesiologists (ASA); 2015 Oct 24-28; San Diego (CA). 2015;():A1064.

A non-opioid adjunct equally or more potent than fentanyl for labor epidural analgesia with less side effects [abstract]. Ross VH, Nelson KE, Booth JL, Harris LC, Eisenach JC, Pan PH.. In: Abstracts of the 2015 Annual Meeting of the American Society of Anesthesiologists (ASA); 2015 Oct 24-28; San Diego (CA). 2015;():A1075.

Recovery of physical activity after cesarean delivery and its relationship with pain [abstract]. Sharpe EE, Booth JL, Pan PH, Aschenbrenner C, Houle TT, Eisenach JC, Harris L.. In: Abstracts of the 2015 Annual Meeting of the American Society of Anesthesiologists (ASA); 2015 Oct 24-28; San Diego (CA). 2015;():A3120.

Down-regulation of astroglial glutamate transporter-1 in the locus coeruleus impairs pain-evoked endogenous analgesia in rats. Kimura M, Suto T, Eisenach JC, Hayashida K.. Neurosci Lett. 2015;608():18-22.

Can a blood test of immune responsiveness predict speed of recovery from pain and dysfunction after surgery? [editorial]. Eisenach JC.. Anesthesiology. 2015;123(6):1221-1223.

Complexities of basic science [reply to letter]. Eisenach JC, Rathmell JP.. Anesthesiology. 2014;120(1):238-239.

Gabapentin increases extracellular glutamatergic level in the locus coeruleus via astroglial glutamate transporter-dependent mechanisms. Suto T, Severino AL, Eisenach JC, Hayashida KI.. Neuropharmacology. 2014;81():95-100.

Preclinical toxicity screening of intrathecal oxytocin in rats and dogs. Yaksh TL, Hobo S, Peters C, Osborn KG, Richter PJ Jr, Rossi SS, Grafe MR, Eisenach JC.. Anesthesiology. 2014;120(4):951-961.

Nociceptor-selective peripheral nerve block induces delayed mechanical hypersensitivity and neurotoxicity in rats. Peters CM, Ririe D, Houle TT, Aschenbrenner CA, Eisenach JC.. Anesthesiology. 2014;120(4):976-986.

Snoring frequency increases during pregnancy and is associated with hypertension and cesarean delivery for labor dystocia [abstract]. Street LM, Matheson D, Mill MP [sic] [Mills MP], Nitsche JF, Pinyan CW, Eisenach J.. In: Abstracts of the 2014 Annual Meeting of the American Society of Anesthesiologists (ASA); 2014 May 14-18; Toronto, Ontario Canada. 2014;():374.

The effects of nerve injury on the expression of vasopressin receptor V1aR in the dorsal root ganglia [abstract]. Lombardo S, Peters C, Eisenach J.. J Pain. 2014;15(4 Suppl 1):S48.

Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain. Suto T, Eisenach JC, Hayashida KI.. Pain. 2014;155(10):1935-1942.

The pain of childbirth and its effect on the mother and the fetus. Pan PH, Eisenach JC. In: Chestnut DH, Wong CA, Tsen LC, Ngan Kee WD, Beilin Y, Mhyre JM, Nathan N, eds. Chestnut's obstetric anesthesia: principles and practice. 5th ed. Philadelphia: Elsevier;2014: 410-426.

Replication to advance science: changes in ANESTHESIOLOGY [editorial]. Eisenach JC, Houle TT.. Anesthesiology. 2014;121(2):209-211.

Modeling individual recovery after peripheral nerve injury in rats and the effects of parturition. Aschenbrenner CA, Houle TT, Gutierrez S, Eisenach JC.. Anesthesiology. 2014;121(5):1056-1067.

Corporate interests necessitate conflict of interest declarations by all authors [reply to letter]. Eisenach JC.. Anesthesiology. 2014;121(2):433.

Fast-conducting mechanoreceptors contribute to withdrawal behavior in normal and nerve injured rats. Danilo Boada M, Martin TJ, Peters CM, Hayashida K, Harris MH, Houle TT, Boyden ES, Eisenach JC, Ririe DG.. Pain. 2014;155(12):2646-2655.

Intrathecal ketorolac does not improve acute or chronic pain after hip arthroplasty: a randomized controlled trial. Wang L, Bauer M, Curry R, Larsson A, Sessler DI, Eisenach JC.. J Anesth. 2014;28(5):790-793.

The puerperium alters spinal cord plasticity following peripheral nerve injury. Gutierrez S, Hayashida K, Eisenach JC.. Neuroscience. 2013;228():301-308.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Anesthesiology

Clinical Interests

Obstetrical Anesthesia, Pain Research
James C. Eisenach, M.D.

James C. Eisenach, M.D.

Professor, Anesthesiology
Office of Women in Medicine and Science

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