James C. Eisenach, M.D.Wake Forest School of Medicine

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James C. Eisenach, M.D.


Clinical Interests

Obstetrical Anesthesia, Pain Research

Contact Information

Department: 336-716-2011


Insurance Accepted »

Education & Training

  • B.A., University of Nebraska-Lincoln, 1976
  • M.S., California Institute of Technology, 1978
  • M.D., University of California Sch of Med-SanFrancisco, 1982
  • Internship, Medicine, Mount Zion Hosp & Med Ctr, 1983
  • Residency, Anesthesiology, Mayo Clinic, 1985
  • Fellowship, WFU School of Medicine, 1986

Board Certifications

  • American Board of Anesthesiology, Anesthesiology


  • Am Medical Assn
  • Am Pain Society
  • Am Soc Of Anesthesiologists
  • Am Soc Of Mass Spectrometry
  • Am Soc of Clinical Oncology
  • Assn Of University Anesthesiol
  • Col.Of Chest Physicians
  • Cons for SE Hypertension Contr
  • Int'l Anesthesia Research Soci
  • Int'l Assn For The Study Of Pa

NPI Number

  • 1932184801
James C. Eisenach, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

James C. Eisenach, M.D.

Professor, Obstetrical and Gynecological Anesthesiology
Office of Women in Medicine and Science
Physiology & Pharmacology

Research Interests

anesthesiology, immunology/allergy/inflammatio, men?s health issues, pain, prevention, surgery/trauma/burns/trauma, women's health issues

Contact Information

Academic: 336-716-4182 | Department: 336-716-2011


Recent Publications

Boada MD, Gutierrez S, Aschenbrenner CA, Houle TT, Hayashida KI, Ririe DG, Eisenach JC. Nerve injury induces a new profile of tactile and mechanical nociceptor input from undamaged peripheral afferents. J Neurophysiol. 2015;113(1):100-109.

Eisenach JC, Tong C, Curry R. Phase 1 safety assessment of intrathecal oxytocin. Anesthesiology. 2015;122(2):407-413.

Martin TJ, Grigg A, Kim SA, Ririe DG, Eisenach JC. Assessment of attention threshold in rats by titration of visual cue duration during the five choice serial reaction time task. J Neurosci Methods. 2015;241():37-43.

Eisenach JC, Tong C, Curry RS. Failure of intrathecal ketorolac to reduce remifentanil-induced postinfusion hyperalgesia in humans. Pain. 2015;156(1):81-87.

Peters CM, Hayashida KI, Suto T, Houle TT, Aschenbrenner CA, Martin TJ, Eisenach JC. Individual differences in acute pain-induced endogenous analgesia predict time to resolution of postoperative pain in the rat. Anesthesiology. 2015;122(4):895-907.

Rauck RL, North J, Eisenach JC. Intrathecal clonidine and adenosine: effects on pain and sensory processing in patients with chronic regional pain syndrome. Pain. 2015;156(1):88-95.

Tedeschi V, Rathmell JP, Eisenach JC. Finding and getting what you want when you want it just got easier at ANESTHESIOLOGY [editorial]. Anesthesiology. 2015;122(3):491-494.

Booth JL, Harris LC, Eisenach JC, Pan PH. A randomized controlled trial comparing two multimodal analgesic techniques in patients predicted to have severe pain after cesarean delivery. Anesth Analg. 2015;():.

Eisenach JC. ANESTHESIOLOGY: attracting the best new science in the specialty [editorial]. Anesthesiology. 2015;122(6):1198-1200.

Hayashida K, Kimura M, Peters C, Eisenach J. Down-regulation of astroglial glutamate transporters in the locus coeruleus contributes to impairment of endogenous analgesia in rats after peripheral nerve injury [abstract]. J Pain. 2015;16(4 Suppl 1):S50.

Severino A, Eisenach J. Anatomical plasticity in spinal oxytocin fibers after peripheral nerve injury [abstract]. J Pain. 2015;16(4 Suppl 1):S45.

Mantz J, Rathmell JP, Eisenach JC. Science, medicine, and the anesthesiologist: two pages to keep you abreast of key papers from outside the specialty and relevant to your practice [editorial]. Anesthesiology. 2015;123(1):.

Booth JL, Sharpe EE, Harris LC, Aschenbrenner C, Houle TT, Eisenach JC. Modeling recovery from pain following non-emergent cesarean delivery [abstract]. In: Abstracts of the 47th Annual SOAP Meeting; 2015 May 13-17; Colorado Springs (CO). 2015;():25.

Pan PH, Nelson K, Ross V, Booth J, Harris L, Eisenach J. A non-opioid adjunct equally or more potent than fentanyl for labor epidural analgesia with less side effects [abstract]. In: Abstracts of the 47th Annual SOAP Meeting; 2015 May 13-17; Colorado Springs (CO). 2015;():51.

Sharpe EE, Booth JL, Harris LC, Aschenbrenner C, Houle TT, Eisenach JC. Recovery of physical activity after cesarean delivery and its relationship with pain [abstract]. In: Abstracts of the 47th Annual SOAP Meeting; 2015 May 13-17; Colorado Springs (CO). 2015;():164.

Kimura M, Suto T, Morado-Urbina CE, Peters CM, Eisenach JC, Hayashida KI. Impaired pain-evoked analgesia after nerve injury in rats reflects altered glutamate regulation in the locus coeruleus. Anesthesiology. 2015;123(4):899-908.

Eisenach JC, Rathmell JP. Complexities of basic science [reply to letter]. Anesthesiology. 2014;120(1):238-239.

Suto T, Severino AL, Eisenach JC, Hayashida KI. Gabapentin increases extracellular glutamatergic level in the locus coeruleus via astroglial glutamate transporter-dependent mechanisms. Neuropharmacology. 2014;81():95-100.

Yaksh TL, Hobo S, Peters C, Osborn KG, Richter PJ Jr, Rossi SS, Grafe MR, Eisenach JC. Preclinical toxicity screening of intrathecal oxytocin in rats and dogs. Anesthesiology. 2014;120(4):951-961.

Peters CM, Ririe D, Houle TT, Aschenbrenner CA, Eisenach JC. Nociceptor-selective peripheral nerve block induces delayed mechanical hypersensitivity and neurotoxicity in rats. Anesthesiology. 2014;120(4):976-986.

Street LM, Matheson D, Mill MP [sic] [Mills MP], Nitsche JF, Pinyan CW, Eisenach J. Snoring frequency increases during pregnancy and is associated with hypertension and cesarean delivery for labor dystocia [abstract]. In: Abstracts of the 2014 Annual Meeting of the American Society of Anesthesiologists (ASA); 2014 May 14-18; Toronto, Ontario Canada. 2014;():374.

Lombardo S, Peters C, Eisenach J. The effects of nerve injury on the expression of vasopressin receptor V1aR in the dorsal root ganglia [abstract]. J Pain. 2014;15(4 Suppl 1):S48.

Suto T, Eisenach JC, Hayashida KI. Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain. Pain. 2014;155(10):1935-1942.

Pan PH, Eisenach JC. The pain of childbirth and its effect on the mother and the fetus In: Chestnut DH, Wong CA, Tsen LC, Ngan Kee WD, Beilin Y, Mhyre JM, Nathan N, eds. Chestnut's obstetric anesthesia: principles and practice. 5th ed. Philadelphia: Elsevier;2014: 410-426.

Eisenach JC, Houle TT. Replication to advance science: changes in ANESTHESIOLOGY [editorial]. Anesthesiology. 2014;121(2):209-211.

Aschenbrenner CA, Houle TT, Gutierrez S, Eisenach JC. Modeling individual recovery after peripheral nerve injury in rats and the effects of parturition. Anesthesiology. 2014;121(5):1056-1067.

Eisenach JC. Corporate interests necessitate conflict of interest declarations by all authors [reply to letter]. Anesthesiology. 2014;121(2):433.

Danilo Boada M, Martin TJ, Peters CM, Hayashida K, Harris MH, Houle TT, Boyden ES, Eisenach JC, Ririe DG. Fast-conducting mechanoreceptors contribute to withdrawal behavior in normal and nerve injured rats. Pain. 2014;155(12):2646-2655.

Wang L, Bauer M, Curry R, Larsson A, Sessler DI, Eisenach JC. Intrathecal ketorolac does not improve acute or chronic pain after hip arthroplasty: a randomized controlled trial. J Anesth. 2014;28(5):790-793.

Gutierrez S, Hayashida K, Eisenach JC. The puerperium alters spinal cord plasticity following peripheral nerve injury. Neuroscience. 2013;228():301-308.

Kimura M, Hayashida K, Eisenach JC, Saito S, Obata H. Relief of hypersensitivity after nerve injury from systemic donepezil involves spinal cholinergic and gamma-aminobutyric acid mechanisms. Anesthesiology. 2013;118(1):173-180.

Gutierrez S, Liu B, Hayashida K, Houle TT, Eisenach JC. Reversal of peripheral nerve injury-induced hypersensitivity in the postpartum period: role of spinal oxytocin. Anesthesiology. 2013;118(1):152-159.

Eisenach JC, Pan P, Smiley RM, Lavand'homme P, Landau R, Houle TT. Resolution of pain after childbirth. Anesthesiology. 2013;118(1):143-151.

Eisenach JC. Case reports are leaving Anesthesiology, but not the specialty [editorial]. Anesthesiology. 2013;118(3):479-480.

Pan PH, Tonidandel AM, Aschenbrenner CA, Houle TT, Harris LC, Eisenach JC. Predicting acute pain after cesarean delivery using three simple questions. Anesthesiology. 2013;118(5):1170-1179.

Turner D, Miller S, Aschenbrenner C, Houle T, Eisenach J. Predicting pain after joint surgery [abstract]. J Pain. 2013;14(4 Suppl 1):S15.

Yoshizumi M, Eisenach JC, Hayashida K. Valproate prevents dysregulation of spinal glutamate and reduces the development of hypersensitivity in rats after peripheral nerve injury. J Pain. 2013;14(11):1485-1491.

Eisenach JC. Patient safety: ANESTHESIOLOGY contributions and supplements to the American Society of Anesthesiologists' annual meeting [editorial]. Anesthesiology. 2013;119(4):745-746.

Wells RE, Burch R, Paulsen R, Wayne P, Aschenbrenner C, Houle TT, Eisenach JC, Loder E. Meditation for migraines: a pilot randomized controlled trial [abstract]. Cephalalgia. 2013;33(8 Suppl):96-97.

Hayashida K-i, Peters CM, Gutierrez S, Eisenach JC. Depletion of endogenous noradrenaline does not prevent spinal cord plasticity following peripheral nerve injury. J Pain. 2012;13(1):49-57.

Yoshizumi M, Eisenach JC, Hayashida K-i. Riluzole and gabapentinoids activate glutamate transporters to facilitate glutamate-induced glutamate release from cultured astrocytes. Eur J Pharmacol. 2012;677(1-3):87-92.

Hobo S, Hayashida K-i, Eisenach JC. Oxytocin inhibits the membrane depolarization-induced increase in intracellular calcium in capsaicin sensitive sensory neurons: a peripheral mechanism of analgesic action. Anesth Analg. 2012;114(2):442-449.

Turner DP, Smitherman TA, Eisenach JC, Penzien DB, Houle TT. Predictors of headache before, during, and after pregnancy: a cohort study. Headache. 2012;52(3):348-362.

Martucci K, Eisenach J, North J, Rauck R, Tong C, Wilson K, Coghill R. Offset analgesia in complex regional pain syndrome [abstract]. J Pain. 2012;13(4 Suppl):S47.

Devereaux PJ, Chan MTV, Eisenach J, Schricker T, Sessler DI. The need for large clinical studies in perioperative medicine [editorial]. Anesthesiology. 2012;116(6):1169-1175.

Martucci KT, Eisenach JC, Tong C, Coghill RC. Opioid-independent mechanisms supporting offset analgesia and temporal sharpening of nociceptive information. Pain. 2012;153(6):1232-1243.

Yoshizumi M, Parker RA, Eisenach JC, Hayashida K-i. Gabapentin inhibits gamma-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats. Anesthesiology. 2012;116(6):1347-1353.

Hayashida K-i, Kimura M, Yoshizumi M, Hobo S, Obata H, Eisenach JC. Ondansetron reverses antihypersensitivity from clonidine in rats after peripheral nerve injury: role of gamma-aminobutyric acid in alpha2-adrenoceptor and 5-HT3 serotonin receptor analgesia. Anesthesiology. 2012;117(2):389-398.

Eisenach JC. Flawed model misrepresents the impact of anesthesiologists to patient safety in the real world [reply to letter]. Anesthesiology. 2012;117(2):441.

Boada MD, Gutierrez S, Giffear K, Eisenach JC, Ririe DG. Skin incision-induced receptive field responses of mechanosensitive peripheral neurons are developmentally regulated in the rat. J Neurophysiol. 2012;108(4):1122-1129.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Obstetrical and Gynecological Anesthesiology

Clinical Interests

Obstetrical Anesthesia, Pain Research

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