Mark A. Espeland, Ph.D.Wake Forest School of Medicine

Mark A. Espeland, Ph.D.


Contact Information

Academic: 336-716-2826 | Department: 336-716-2011


Education & Training

  • B.S., Arizona State University-Tempe Campps, 1974
  • Ph.D., University of Rochester, 1981
  • M.A., University of Rochester, 1981


  • American Academy of Neurology
  • Am Assn Of Advancement Of Scie
  • Soc Clin Trials
  • Am Diabetes Assn
  • Am Statistical Assn
  • Biometric Society
Mark A. Espeland, Ph.D.

Mark A. Espeland, Ph.D.

Professor, Biostatistical Sciences
Center on Diabetes, Obesity, and Metabolism

Research Interests

Cognition; Cognition Disorders; Diabetes Mellitus, Type 2; Obesity; Women's Health
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Contact Information

Academic: 336-716-2826 | Department: 336-716-2011


Recent Publications

Effect of a long-term intensive lifestyle intervention on cognitive function: Action for Health in Diabetes study. Rapp SR, Luchsinger JA, Baker LD, Blackburn GL, Hazuda HP, Demos-McDermott KE, Jeffery RW, Keller JN, McCaffery JM, Pajewski NM, Evans M, Wadden TA, Arnold SE, Espeland MA.. J Am Geriatr Soc. 2017;():.

Objective estimates of physical activity and sedentary time among young adults. Unick JL, Lang W, Tate DF, Bond DS, Espeland MA, Wing RR.. J Obes. 2017;2017():9257564.

Global cognitive function before, surrounding, and after ischemic stroke: the role of risk and protective factors varies with time among ischemic stroke survivors. Vaughan L, Bushnell C, Bell CL, Espeland MA.. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2016;23(1):117-131.

Sleep duration, cognitive decline, and dementia risk in older women. Chen JC, Espeland MA, Brunner RL, Lovato LC, Wallace RB, Leng X, Phillips LS, Robinson JG, Kotchen JM, Johnson KC, Manson JE, Stefanick ML, Sarto GE, Mysiw WJ.. Alzheimers Dement. 2016;12(1):21-33.

Longitudinal cognitive trajectories of women Veterans from the Women's Health Initiative Memory Study. Padula CB, Weitlauf JC, Rosen AC, Reiber G, Cochrane BB, Naughton MJ, Li W, Rissling M, Yaffe K, Hunt JR, Stefanick ML, Goldstein MK, Espeland MA.. Gerontologist. 2016;56(1):115-125.

Prospective association of GLUL rs10911021 with cardiovascular morbidity and mortality among individuals with type 2 diabetes: the Look AHEAD Study. Huggins GS, Berkowitz RI, Blackburn GL, Bray GA, Cheskin L, Clark JM, Coday M, Espeland MA, Evans M, Foreyt JP, Glasser S, Greenway FL, Gregg EW, Hanson RL, Hazuda HP, Hill JO, Horton ES, Jakicic JM, Jeffery RW, Johnson KC, Kahn SE, Kitzman DW,.. Diabetes. 2016;65(1):297-302.

Predictors of optimal cognitive aging in 80+ women: the Women's Health Initiative Memory Study. Goveas JS, Rapp SR, Hogan PE, Driscoll I, Tindle HA, Smith JC, Kesler SR, Zaslavsky O, Rossom RC, Ockene JK, Yaffe K, Manson JE, Resnick SM, Espeland MA.. J Gerontol A Biol Sci Med Sci. 2016;71(Suppl 1):S62-S71.

Cost-effectiveness of the LIFE physical activity intervention for older adults at increased risk for mobility disability. Groessl EJ, Kaplan RM, Castro Sweet CM, Church T, Espeland MA, Gill TM, Glynn NW, King AC, Kritchevsky S, Manini T, McDermott MM, Reid KF, Rushing J, Pahor M.. J Gerontol A Biol Sci Med Sci. 2016;71(5):656-662.

Red blood cell fatty acids and incident diabetes mellitus in the Women's Health Initiative Memory Study. Harris WS, Luo J, Pottala JV, Margolis KL, Espeland MA, Robinson JG.. PLoS One. 2016;11(2):e0147894.

The relationship of social support with treatment adherence and weight loss in Latinos with type 2 diabetes. Marquez B, Anderson A, Wing RR, West DS, Newton RL, Meacham M, Hazuda HP, Peters A, Montez MG, Broyles ST, Walker M, Evans-Hudsnall G, Espeland MA, et al.. Obesity (Silver Spring). 2016;24(3):568-575.

Effects of hormone therapy on brain volumes changes of postmenopausal women revealed by optimally-discriminative voxel-based morphometry. Zhang T, Casanova R, Resnick SM, Manson JE, Baker LD, Padual CB, Kuller LH, Bryan RN, Espeland MA, Davatzikos C.. PLoS One. 2016;11(3):e0150834.

Obesity and structural brain integrity in older women: the Women's Health Initiative Magnetic Resonance Imaging Study. Driscoll I, Gaussoin SA, Wassertheil-Smoller S, Limacher M, Casanova R, Yaffe K, Resnick SM, Espeland MA.. J Gerontol A Biol Sci Med Sci. 2016;71(9):1216-1222.

Impact of intensive lifestyle intervention on preference-based quality of life in type 2 diabetes: results from the Look AHEAD trial. Zhang P, Hire D, Espeland MA, Knowler WC, Thomas S, Tsai AG, Glick HA.. Obesity (Silver Spring). 2016;24(4):856-864.

Abnormalities in diffusional kurtosis metrics related to head impact exposure in a season of high school varsity football. Davenport EM, Apkarian K, Whitlow CT, Urban JE, Jensen JH, Szuch E, Espeland MA, Jung Y, Rosenbaum DA, Gioia G, Powers AK, Stitzel JD, Maldjian JA.. J Neurotrauma. 2016;33(23):2133-2146.

Innovative self-regulation strategies to reduce weight gain in young adults: the Study of Novel Approaches to Weight Gain Prevention (SNAP) randomized clinical trial. Wing RR, Tate DF, Espeland MA, Lewis CE, LaRose JG, Gorin AA, Bahnson J, Perdue LH, Hatley KE, Ferguson E, Garcia KR, Lang W.. JAMA Intern Med. 2016;176(6):755-762.

The evolution of the WHI 80+ cohort. Beavers DP, Pettinger M, Espeland MA, Snively BM, Leng X, Hunt JR, Tindle HA, Shumaker SA.. J Gerontol A Biol Sci Med Sci. 2016;71(Suppl 1):S13-S22.

Brain and white matter hyperintensity volumes after 10 years of random assignment to lifestyle intervention. Espeland MA, Erickson K, Neiberg RH, Jakicic JM, Wadden TA, Wing RR, Desiderio L, Erus G, Hsieh MK, Davatzikos C, Maschak-Carey BJ, Laurienti PJ, Demos-McDermott K, Bryan RN.. Diabetes Care. 2016;39(5):764-771.

Metformin as a tool to target aging. Barzilai N, Crandall JP, Kritchevsky SB, Espeland MA.. Cell Metab. 2016;23(6):1060-1065.

Recruitment of young adults for weight gain prevention: randomized comparison of direct mail strategies. Crane MM, LaRose JG, Espeland MA, Wing RR, Tate DF.. Trials. 2016;17(1):282.

Long-term effects on cognitive trajectories of postmenopausal hormone therapy in two age groups. Espeland MA, Rapp SR, Manson JE, Goveas JS, Shumaker SA, Hayden KM, Weitlauf JC, Gaussoin SA, Baker LD, Padula CB, Hou L, Resnick SM.. J Gerontol A Biol Sci Med Sci. 2016;():.

Changes in regional body composition over 8 years in a randomized lifestyle trial: the Look AHEAD study. Pownall HJ, Schwartz AV, Bray GA, Berkowitz RI, Lewis CE, Boyko EJ, Jakicic JM, Chen H, Heshka S, Gregg EW, Johnson KC, Espeland M.. Obesity (Silver Spring). 2016;24(9):1899-1905.

Impact of moderate physical activity on the longitudinal trajectory of a cardiac specific biomarker of injury: results from a randomized pilot study of exercise intervention. deFilippi CR, de Lemos JA, Newman AB, Guralnik JM, Christenson RH, Pahor M, Church T, Espeland M, Krithevsky SB [sic] [Kritchevsky SB], Stafford R, Seliger SL.. Am Heart J. 2016;179():151-156.

Effects of physical activity intervention on physical and cognitive function in sedentary adults with and without diabetes. Espeland MA, Lipska K, Miller ME, Rushing J, Cohen RA, Verghese J, McDermott MM, King AC, Strotmeyer ES, Blair SN, Pahor M, Reid K, Demons J, Kritchevsky SB.. J Gerontol A Biol Sci Med Sci. 2016;():.

Relative differences in resting-state brain connectivity associated with long term intensive lifestyle intervention. Casanova R, Hayasaka S, Saldana S, Bryan NR, Demos KE, Desiderio L, Erickson KI, Espeland MA, Nasrallah IM, Wadden T, Laurienti PJ.. Psychoneuroendocrinology. 2016;74():231-239.

Relationships between caffeine intake and risk for probable dementia or global cognitive impairment: the Women's Health Initiative Memory Study. Driscoll I, Shumaker SA, Snively BM, Margolis KL, Manson JE, Vitolins MZ, Rossom RC, Espeland MA.. J Gerontol A Biol Sci Med Sci. 2016;71(12):1596-1602.

Sex biology contributions to vulnerability to Alzheimer's disease: a think tank convened by the Women's Alzheimer's Research Initiative. Snyder HM, Asthana S, Bain L, Brinton R, Craft S, Dubal DB, Espeland MA, Gatz M, Mielke MM, Raber J, Rapp PR, Yaffe K, Carrillo MC.. Alzheimers Dement. 2016;12(11):1186-1196.

Association of weight loss maintenance and weight regain on 4-year changes in CVD risk factors: the Action for Health in Diabetes (Look AHEAD) Clinical Trial. Wing RR, Espeland MA, Clark JM, Hazuda HP, Knowler WC, Pownall HJ, Unick J, Wadden T, Wagenknecht L.. Diabetes Care. 2016;39(8):1345-1355.

A voxel-based morphometry study reveals local brain structural alterations associated with ambient fine particles in older women. Casanova R, Wang X, Reyes J, Akita Y, Serre ML, Vizuete W, Chui HC, Driscoll I, Resnick SM, Espeland MA, Chen JC.. Front Hum Neurosci. 2016;10():495.

The use of electronic medical records for recruitment in clinical trials: findings from the Lifestyle Intervention for Treatment of Diabetes trial. Effoe VS, Katula JA, Kirk JK, Pedley CF, Bollhalter LY, Brown WM, Savoca MR, Jones ST, Baek J, Bertoni AG, Faust D, Gower E, Freehill K, Logan K, Bell RA, Espeland M, et al.. Trials. 2016;17(1):496.

Targeting aging with metformin (TAME): a study to target aging in humans [abstract]. Barzilai N, Kritchevsky S, Espeland M, Crandall J.. Gerontologist. 2016;56(Suppl 3):199.

Benchmarks for designing clinical trials with multiple morbidity outcomes [abstract]. Espeland M, Crimmins E, Grossardt B, Harris TB, Kritchevsky S, Rocca W, Temprosa M, Barzilai N.. Gerontologist. 2016;56(Suppl 3):251-252.

Ankle-brachial index and inter-artery blood pressure differences as predictors of cognitive function in overweight and obese older adults with diabetes: results from the Action for Health in Diabetes movement and memory study. Espeland MA, Beavers KM, Gibbs BB, Johnson KC, Hughes TM, Baker LD, Jakicic J, Korytkowski M, Miller M, Bray GA.. Int J Geriatr Psychiatry. 2015;30(10):999-1007.

Systolic blood pressure control among individuals with type 2 diabetes: a comparative effectiveness analysis of three interventions. Espeland MA, Probstfield J, Hire D, Redmon JB, Evans GW, Coday M, Lewis CE, Johnson KC, Wilmoth S, Bahnson J, Dulin MF, Green JB, Knowler WC, Kitabchi A, Murillo AL, Osei K, Rehman SU, Cushman WC, Ambrosius WT, Greven CM, Lovato JF, Perdue LH, et al.. Am J Hypertens. 2015;28(8):995-1009.

Design and baseline characteristics of the CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes (CAROLINA). Marx N, Rosenstock J, Kahn SE, Zinman B, Kastelein JJ, Lachin JM, Espeland MA, Bluhmki E, Mattheus M, Ryckaert B, Patel S, Johansen OE, Woerle HJ.. Diab Vasc Dis Res. 2015;12(3):164-174.

Improving adiponectin levels in individuals with diabetes and obesity: insights from Look AHEAD. Belalcazar LM, Lang W, Haffner SM, Schwenke DC, Kriska A, Balasubramanyam A, Hoogeveen RC, Pi-Sunyer FX, Tracy RP, Ballantyne CM, Espeland MA, et al.. Diabetes Care. 2015;38(8):1544-1550.

Ambient air pollution and neurotoxicity on brain structure: evidence from Women's Health Initiative Memory Study. Chen JC, Wang X, Wellenius GA, Serre ML, Driscoll I, Casanova R, McArdle JJ, Manson JE, Chui HC, Espeland MA.. Ann Neurol. 2015;78(3):466-476.

Frequent self-weighing as part of a constellation of healthy weight control practices in young adults. Wing RR, Tate D, LaRose JG, Gorin AA, Erickson K, Robichaud EF, Perdue L, Bahnson J, Espeland MA... Obesity (Silver Spring). 2015;23(5):943-949.

Postmenopausal hormone therapy, type 2 diabetes mellitus, and brain volumes. Espeland MA, Brinton RD, Manson JE, Yaffe K, Hugenschmidt C, Vaughan L, Craft S, Edwards BJ, Casanova R, Masaki K, Resnick SM.. Neurology. 2015;85(13):1131-1138.

Can an intensive diet and exercise program prevent knee pain among overweight adults at high risk. White DK, Neogi T, Rejeski WJ, Walkup MP, Lewis CE, Nevitt MC, Foy CG, Felson DT, Espeland MA.. Arthritis Care Res (Hoboken). 2015;67(7):965-971.

Weight change in the first 2 months of a lifestyle intervention predicts weight changes 8 years later. Unick JL, Neiberg RH, Hogan PE, Cheskin LJ, Dutton GR, Jeffery R, Nelson JA, Pi-Sunyer X, West DS, Wing RR, Espeland MA.. Obesity (Silver Spring). 2015;23(7):1353-1356.

Genetic predisposition to weight loss and regain with lifestyle intervention: analyses from the Diabetes Prevention Program and the Look AHEAD randomized controlled trials. Papandonatos GD, Pan Q, Pajewski NM, Delahanty LM, Peter I, Erar B, Ahmad S, Harden M, Chen L, Fontanillas P, Wagenknecht LE, Kahn SE, Wing RR, Jablonski KA, Huggins GS, Knowler WC, Florez JC, McCaffery JM, Franks PW, Espeland MA, et al.. Diabetes. 2015;64(12):4312-4321.

Associations between ankle-brachial index and cognitive function: results from the Lifestyle Interventions and Independence for Elders Trial. Espeland MA, Newman AB, Sink K, Gill TM, King AC, Miller ME, Guralnik J, Katula J, Church T, Manini T, Reid KF, McDermott MM.. J Am Med Dir Assoc. 2015;16(8):682-689.

Prospective association of a genetic risk score and lifestyle intervention with cardiovascular morbidity and mortality among individuals with type 2 diabetes: the Look AHEAD randomised controlled trial. McCaffery JM, Anderson A, Bantle JP, Berkowitz RI, Bray GA, Cheskin L, Clark JM, Curtis JM, Delahanty LM, Evans M, Foreyt JP, Glasser S, Gregg EW, Hanson RL, Hazuda HP, Hill JO, Horton ES, Huggins GS, Jakicic JM, Jeffery RW, Johnson KC,.. Diabetologia. 2015;58(8):1803-1813.

Effect of a 24-month physical activity intervention vs health education on cognitive outcomes in sedentary older adults: the LIFE randomized trial. Sink KM, Espeland MA, Castro CM, Church T, Cohen R, Dodson JA, Guralnik J, Hendrie HC, Jennings J, Katula J, Lopez OL, McDermott MM, Pahor M, Reid KF, Rushing J, Verghese J, Rapp S, Williamson JD.. JAMA. 2015;314(8):781-790.

Effect of an intensive lifestyle intervention on atrial fibrillation risk in individuals with type 2 diabetes: the Look AHEAD randomized trial. Alonso A, Bahnson JL, Gaussoin SA, Bertoni AG, Johnson KC, Lewis CE, Vetter M, Mantzoros CS, Jeffery RW, Soliman EZ, Espeland MA.. Am Heart J. 2015;170(4):770-777.e5.

Impact of type 2 diabetes and postmenopausal hormone therapy on incidence of cognitive impairment in older women. Espeland MA, Brinton RD, Hugenschmidt C, Manson JE, Craft S, Yaffe K, Weitlauf J, Vaughan L, Johnson KC, Padula CB, Jackson RD, Resnick SM.. Diabetes Care. 2015;38(12):2316-2324.

Self-reported gastrointestinal symptoms in type 2 diabetes improve with an intensive lifestyle intervention: results from the Action for Health in Diabetes (Look AHEAD) clinical trial. Neiberg RH, Rejeski JJ, Applegate WB, Clark JM, Knowler WC, Bray GA, Espeland MA, Cheskin LJ.. Clin Diabetes. 2015;33(4):181-188.

Genetic predictors of depressive symptoms in the Look AHEAD trial. McCaffery JM, Papandonatos GD, Faulconbridge LF, Erar B, Peter I, Wagenknecht LE, Pajewski NM, Anderson A, Wadden TA, Wing RR, Espeland M.. Psychosom Med. 2015;77(9):982-992.

Cost-effectiveness of the LIFE-M physical activity intervention for older adults [abstract]. Groessl EJ, Kaplan RM, Castro CM, Espeland MA, Pahor M.. Gerontologist. 2015;55(Suppl 2):561.

Change in brain and lesion volumes after CEE therapies: the WHIMS-MRI studies. Coker LH, Espeland MA, Hogan PE, Resnick SM, Bryan RN, Robinson JG, Goveas JS, Davatzikos C, Kuller LH, Williamson JD, Bushnell CD, Shumaker SA.. Neurology. 2014;82(5):427-434.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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