Mark A. Espeland, Ph.D.
Professor, Department of Biostatistics
Translational Science Institute
Sticht Center on Aging
Center for Diabetes Research
Women's Health Center of Excellence for Research, Leadership, Education
WFU Primate Center
Center for Integrative Medicine
Translational Science Institute
Research Interests
aging, cognition/learning, diabetes, drugs/therapeutic agents pharm, environmental sciences, epidemiology, fitness/physical, nutrition
Contact Information
Academic: 336-716-2826 | Department: 336-716-2011
Email: mespelan@wakehealth.edu
Recent Publications
Espeland MA, Bryan RN, Goveas JS, Robinson JG, Siddiqui MS, Liu S, Hogan PE, Casanova R, Coker LH, Yaffe K, Masaki K, Rossom R, Resnick SM.
Influence of type 2 diabetes on brain volumes and changes in brain volumes: results from the Women's Health Initiative magnetic resonance imaging studies. Diabetes Care. 2013;36(1):90-97.
Mount DL, Davis C, Kennedy B, Raatz S, Dotson K, Gary-Webb TL, Thomas S, Johnson KC, Espeland MA, Bahnson J, Wagenknecht L, Reboussin D, Rejeski WJ, Lang W, Bertoni A, Vitolins M, Miller G, Ribisl P, Hodges A,.
Factors influencing enrollment of African Americans in the Look AHEAD trial. Clin Trials. 2012;9(1):80-89.
Phelan S, Kanaya AM, Subak LL, Hogan PE, Espeland MA, Wing RR, Burgio KL, DiLillo V, Gorin AA, West DS, Brown JS.
Weight loss prevents urinary incontinence in women with type 2 diabetes: results from the Look AHEAD trial. J Urol. 2012;187(3):939-944.
Haan M, Espeland MA, Klein BE, Casanova R, Gaussoin SA, Jackson RD, Millen AE, Resnick SM, Rossouw JE, Shumaker SA, Wallace R, Yaffe K.
Cognitive function and retinal and ischemic brain changes: the Women's Health Initiative. Neurology. 2012;78(13):942-949.
Crane MM, Tate DF, LaRose JG, Wing RR, Espeland M. Randomized comparison of messages for recruiting men into a weight gain prevention trial [abstract]. Ann Behav Med. 2012;43(Suppl 1):S191.
Faulconbridge LF, Wadden TA, Rubin RR, Wing RR, Walkup MP, Fabricatore AN, Coday M, Van Dorsten B, Mount DL, Ewing LJ, Espeland MA, Bahnson JL, Wagenknecht L, Reboussin D, Rejeski WJ, Bertoni A, Lang W, Miller G, Lefkowitz D,.
One-year changes in symptoms of depression and weight in overweight/obese individuals with type 2 diabetes in the Look AHEAD study. Obesity (Silver Spring). 2012;20(4):783-793.
Schwartz AV, Johnson KC, Kahn SE, Shepherd JA, Nevitt MC, Peters AL, Walkup MP, Hodges A, Williams CC, Bray GA, Espeland MA, Bahnson JL, Wagenknecht L, Reboussin D, Rejeski WJ, Bertoni A, Lang W, Miller G, Lefkowitz D, Reynolds PS,.
Effect of 1 year of an intentional weight loss intervention on bone mineral density in type 2 diabetes: results from the Look AHEAD randomized trial. J Bone Miner Res. 2012;27(3):619-627.
Tate DF, LaRose JG, Espeland M, Bahnson J, Ferguson E, Erickson KE, Perdue L, Wing RR. Recruitment of young adults for weight gain prevention [abstract]. Ann Behav Med. 2012;43(Suppl 1):S240.
Goveas JS, Hogan PE, Kotchen JM, Smoller JW, Denburg NL, Manson JE, Tummala A, Mysiw WJ, Ockene JK, Woods NF, Espeland MA, Wassertheil-Smoller S.
Depressive symptoms, antidepressant use, and future cognitive health in postmenopausal women: the Women's Health Initiative Memory Study. Int Psychogeriatr. 2012;24(8):1252-1264.
Woods NF, Cochrane BB, LaCroix AZ, Seguin RA, Zaslavsky O, Liu J, Beasley JM, Brunner RL, Espeland MA, Goveas JS, Lane DS, Manson JE, Mouton CP, Robinson JG, Tinker LF.
Toward a positive aging phenotype for older women: observations from the Women's Health Initiative. J Gerontol A Biol Sci Med Sci. 2012;67(11):1191-1196.
Espeland MA, Castro CM, Jennings JM, Katula JA, Kerwin DR, Kramer A, Rushing J. Performance of a computer-based assessment of cognitive function in two cohorts of seniors [abstract]. Gerontologist. 2012;52(Suppl 1):304.
Kerwin DR, Gaussoin SA, Chlebowski RT, Kuller LH, Vitolins M, Coker LH, Kotchen JM, Nicklas BJ, Wassertheil-Smoller S, Espeland MA, et al.
Interaction between body mass index and central adiposity and risk of incident cognitive impairment and dementia: results from the Women's Health Initiative Memory Study. J Am Geriatr Soc. 2011;59(1):107-112.
Casanova R, Espeland MA, Goveas JS, Davatzikos C, Gaussoin SA, Maldjian JA, Brunner RL, Kuller LH, Johnson KC, Wagner B, et al.
Application of machine learning methods to describe the effects of conjugated equine estrogens therapy on region-specific brain volumes. Magn Reson Imaging. 2011;29(4):546-553.
Legault C, Jennings JM, Katula JA, Dagenbach D, Gaussoin SA, Sink KM, Rapp SR, Rejeski WJ, Shumaker SA, Espeland MA.
Designing clinical trials for assessing the effects of cognitive training and physical activity interventions on cognitive outcomes: the Seniors Health and Activity Research Program Pilot (SHARP-P) Study, a randomized controlled trial. BMC Geriatr. 2011;11(1):article 27.
Katula JA, Lucas A, Jennings JM, Legault C, Gaussoin S, Yamamoto K, Dagenbach D, Sink K, Rapp S, Rejeski J, Espeland M. The role of executive function in 400 M walk performance: the Senior'S Health & Activity Research Program-Pilot (Sharp-P) [abstract]. Ann Behav Med. 2011;41(Suppl 1):s113.
Goveas JS, Espeland MA, Hogan P, Dotson V, Tarima S, Coker LH, Ockene J, Brunner R, Woods NF, Wassertheil-Smoller S, et al.
Depressive symptoms, brain volumes and subclinical cerebrovascular disease in postmenopausal women: the Women's Health Initiative MRI Study. J Affect Disord. 2011;132(1-2):275-284.
Belalcazar LM, Ballantyne CM, Lang W, Rushing J, Espeland MA, Bahnson JL, Wagenknecht L, Reboussin D, Rejeski WJ, Bertoni A, Miller G, Lefkowitz D, Reynolds PS, Ribisl P, Vitolins M, Booth M, Dotson KM, Hodges A, Williams CC,.
Metabolic factors, adipose tissue, and plasminogen activator inhibitor-1 levels in type 2 diabetes: findings from the Look AHEAD study. Arterioscler Thromb Vasc Biol. 2011;31(7):1689-1695.
Shih RA, Ghosh-Dastidar B, Margolis KL, Slaughter ME, Jewell A, Bird CE, Eibner C, Denburg NL, Ockene J, Espeland MA, et al.
Neighborhood socioeconomic status and cognitive function in women. Am J Public Health. 2011;101(9):1721-1728.
Fielding RA, Rejeski WJ, Blair S, Church T, Espeland MA, Gill TM, Guralnik JM, Hsu F-C, Katula J, King AC, Kritchevsky SB, McDermott MM, Miller ME, Nayfield S, Newman AB, Williamson JD, Bonds D, Romashkan S, Hadley E, Pahor M.
The Lifestyle Interventions and Independence for Elders Study: design and methods. J Gerontol A Biol Sci Med Sci. 2011;66(11):1226-1237.
Espeland MA, Miller ME, Goveas JS, Hogan PE, Coker LH, Williamson J, Naughton M, Resnick SM. Domain-specific cognitive function and fine motor speed in women 65 years and older with type 2 diabetes mellitus: results from the Women's Health Initiative Study of Cognitive Aging [abstract]. Diabetes. 2011;60(Suppl 1):A69-A70.
Shea M, Houston DK, Nicklas B, Miller ME, Messier SP, Espeland MA, Kritchevsky SB. The effect of intentional weight loss on total mortality in older adults: a pooled analysis of two randomized-controlled trials [abstract]. Gerontologist. 2011;51(Suppl 2):518.
Atkinson HH, Rapp SR, Williamson JD, Lovato J, Absher JR, Gass M, Henderson VW, Johnson KC, Sink KM, Espeland MA, et al.
The relationship between cognitive function and physical performance in older women: results from the Women's Health Initiative Memory Study. J Gerontol A Biol Sci Med Sci. 2010;65(3):300-306.
Espeland MA, Shumaker SA, Limacher M, Rapp SR, Bevers TB, Barad DH, Coker LH, Gaussoin SA, Stefanick ML, Lane DS, et al.
Relative effects of tamoxifen, raloxifene, and conjugated equine estrogens on cognition. J Womens Health. 2010;19(3):371-379.
Burdette JH, Laurienti PJ, Espeland MA, Morgan A, Telesford Q, Vechlekar CD, Hayasaka S, Jennings JM, Katula JA, Kraft RA, Rejeski WJ.
Using network science to evaluate exercise-associated brain changes in older adults. Front Aging Neurosci. 2010;2():article 23.
Katula JA, Vitolins MZ, Rosenberger EL, Blackwell C, Isom SP, Espeland MA, Lawlor MS, Goff DC. Correlates of health-related quality of life in overweight and obese adults with prediabetes [abstract]. Ann Behav Med. 2010;39(Suppl 1):207.
Klepin HD, Geiger AM, Costantino JP, Sink KM, Lawrence JA, Espeland MA. Association between domain-specific cognitive function and adherence to oral anti-cancer therapy: results from Cognition in the Study of Tamoxifen and Raloxifene (Co-STAR) [abstract]. J Am Geriatr Soc. 2010;58(Suppl 1):86-87.
Kerwin DR, Zhang Y, Kotchen JM, Espeland MA, Van Horn L, McTigue KM, Robinson JG, Powell L, Kooperberg C, Coker LH, et al.
The cross-sectional relationship between body mass index, waist-hip ratio, and cognitive performance in postmenopausal women enrolled in the Women's Health Initiative. J Am Geriatr Soc. 2010;58(8):1427-1432.
Casanova R, Espeland MA, Goveas J, Davatzikos C, Gaussoin SA, Wagner B, Maldjian JA, Resnick SM. Application of machine learning methods to describe the effects of conjugated equine estrogens therapy on region-specific brain volumes [abstract]. Gerontologist. 2010;50(Suppl 1):308-309.
Espeland MA. Designing clinical trials to assess the effects of behavioral interventions on cognitive outcomes in seniors [abstract]. Gerontologist. 2010;50(Suppl 1):415.
Rapp S, Espeland MA, Manson JE, Resnick S, Bryan NR, Coker LH, Phillips L, Stefanick ML. Educational attainment, MRI changes and cognitive function in postmenopausal women [abstract]. Gerontologist. 2010;50(Suppl 1):308.
Shumaker SA, Espeland MA, Leng X, Limacher M, Manson JE, Stefanick ML. Cognitive function and cognitive change on incident CCD: the WHI Memory Study (WHIMS) [abstract]. Gerontologist. 2010;50(Suppl 1):309.
Gaussion S [sic] [Gaussoin S], Espeland MA, Rapp SR, Katula JA, Andrews LA, Felton D, Dagenbach D, Legault C, Sink KM. Use of the telephone interview for cognitive status (TICS) to screen volunteers for clinical trials of physical activity and cognitive training interventions; the Seniors Health and Activity Research Program [abstract]. Clin Trials. 2010;7(4):476.
Wing RR, Bahnson JL, Bray GA, Clark JM, Coday M, Egan C, Espeland MA, Reboussin D, Rejeski WJ, Wagenknecht L, et al.
Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial. Arch Intern Med. 2010;170(17):1566-1575.
Bhasin S, Espeland MA, Evans WJ, Ferrucci L, Fried LP, Gill TM, Pahor M, Studenski S, Guralnik J, Nayfi S, et al.
Indications, labeling, and outcomes assessment for drugs aimed at improving functional status in older persons: a conversation between aging researchers and FDA regulators. J Gerontol A Biol Sci Med Sci. 2009;64(4):487-491.
Alexander TH, Weisman MH, Derebery JM, Espeland MA, Gantz BJ, Gulya AJ, Hammerschlag PE, Hannley M, Hughes GB, Moscicki R, et al.
Safety of high-dose corticosteroids for the treatment of autoimmune inner ear disease. Otol Neurotol. 2009;30(4):443-448.
Ding J, Hsu F-C, Harris TB, Liu Y, Kritchevsky SB, Szklo M, Ouyang P, Espeland MA, Lohman KK, Carr JJ, et al.
The association of pericardial fat with incident coronary heart disease: the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Clin Nutr. 2009;90(3):499-504.
Phelan S, Kanaya AM, Subak LL, Hogan PE, Espeland MA, Wing RR, Burgio KL, DiLillo V, Gorin AA, West DS, et al.
Prevalence and risk factors for urinary incontinence in overweight and obese diabetic women: Action for Health in Diabetes (Look AHEAD) study. Diabetes Care. 2009;32(8):1391-1397.
Mount DL, Feeney P, Fabricatore AN, Coday M, Bahnson J, Byington R, Phelan S, Wilmoth S, Knowler WC, Espeland MA, et al.
Constructing common cohorts from trials with overlapping eligibility criteria: implications for comparing effect sizes between trials. Clin Trials. 2009;6(5):416-429.
Espeland MA, Tindle HA, Bushnell CA, Jaramillo SA, Kuller LH, Margolis KL, Mysiw WJ, Maldjian JA, Melhem ER, Resnick SM.
Brain volumes, cognitive impairment, and conjugated equine estrogens. J Gerontol A Biol Sci Med Sci. 2009;64(12):1243-1250.
Bushnell C, Tindle H, Espeland M, Jamillo S, Melhem E, Resnick S. Regional brain and ischemic lesion volumes in women with cognitive impairment following exposure to conjugated equine estrogen therapies (CEE): the Women's Health Initiative Magnetic Resonance Imaging Study (WHIMS-MRI) [abstract]. Neurology. 2009;72(11 Suppl 3):A171-A172.
Bandelow S, Espeland MA, Henderson VW, Resnick SM, Wallace RB, Coker LH, Hogervorst E.
Identifying risk factors for cognitive change in the Women's Health Initiative: a neural networks approach In: Hogervorst E, Henderson VW, Gibbs RB, Brinton RD, eds. Hormones, cognition and dementia: state of the art and emergent therapeutic strategies. New York: Cambridge University Press;2009: 11-24.
Barad DH, Bevers TB, Coker LH, Espeland MA, Jaramillo SA, Limacher M, Lane DS, Rapp S, Maki P, Shumaker SA, et al. Relative effects of tamoxifen, raloxifene, and estrogen therapy on cognition: results from the Women's Health Initiative Memory Study (WHIMS) and the Cognition in the Study of Tamoxifen and Raloxifene (CoSTAR) clinical trials [abstract]. Reprod Sci. 2008;15(2 Suppl):309A.
Atkinson HH, Williamson JD, Rapp SR, Lovato J, Sink KM, Absher JR, Gass M, Henderson V, Johnson KC, Espeland MA, et al. Grip strength predicts dementia in 75 to 80 year-old women: the Women's Health Initiative Memory Study (WHIMS) [abstract]. J Am Geriatr Soc. 2008;56(4 Suppl):S107.
Bhasin S, Cress E, Espeland MA, Evans WJ, Ferrucci L, Fried LP, Gill TM, Pahor M, Studenski S, Guralnik J, et al.
Functional outcomes for clinical trials in frail older persons: time to be moving. J Gerontol A Biol Sci Med Sci. 2008;63(2):160-164.
Underhill HR, Yuan C, Terry JG, Chen H, Espeland MA, Kraft R, Carr JJ, Maldjian J, Tang R, Crouse JR III, et al.
Differences in carotid arterial morphology and composition between individuals with and without obstructive coronary artery disease: a cardiovascular magnetic resonance study. J Cardiovasc Magn Reson. 2008;10(1):article 31.
Johnson KC, Margolis KL, Espeland MA, Colenda CC, Fillit H, Manson JE, Masaki KH, Mouton CP, Prineas R, Robinson JG, et al.
A prospective study of the effect of hypertension and baseline blood pressure on cognitive decline and dementia in postmenopausal women: the Women's Health Initiative Memory Study. J Am Geriatr Soc. 2008;56(8):1449-1458.
Espeland MA, Bryan NR, Coker LH, Manson J, Phillips LS, Rapp SR, Sarto GE, Stefanick ML, Wassertheil-Smoller S. Influence of educational attainment and occupation on relationships that cognitive function has with MRI-based neuropathology, mild cognitive impairment, and dementia: results from the Women's Health Initative Memory Study [abstract]. Alzheimers Dement. 2008;4(4 Suppl 1):T672.
Marsh A, Rejeski W, Espeland M, Miller M, Church T, Gill T, Guralnik J, Vestergaard S, Newman A, Pahor M. Predictors of risk for major mobility disability in the Lifestyle Interventions and Independence for Elders Pilot (Life-P) [abstract]. Gerontologist. 2008;48(Special Issue 3):197-198.
Vestergaard S, Walkup M, Pahor M, Marsh A, Espeland M, Studenski S, Gill T, Church T, M GJ [sic ] [Guralnik JM]. Stopping to rest during a 400-meter walk and incident mobility disability in older persons with functional limitations [abstract]. Gerontologist. 2008;48(Special Issue 3):198.
Chambers MS, Fleming TJ, Toth BB, Lemon JC, Craven TE, Bouwsma OJ, Garden AS, Espeland MA, Keene HJ, Martin JW, et al.
Erratum to 'Clinical evaluation of the intraoral fluoride releasing system in radiation-induced xerostomic subjects. Part 2: Phase I study'. Oral Oncol. 2007;43(1):98-105.
Pi-Sunyer X, Blackburn G, Brancati FL, Bray GA, Bright R, Clark JM, Curtis JM, Espeland MA, Foreyt JP, Wagenknecht L, et al.
Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the Look AHEAD Trial. Diabetes Care. 2007;30(6):1374-1383.
Espeland MA, Bahnson J, Wagenknecht, Reboussin D, Rejeski WJ, Lang W, Bertoni A, Vitolins M, Miller G, Ribisl P, Dotson K, Hodges A, Hogan P, et al.
The Look AHEAD Study: a description of the lifestyle intervention and the evidence supporting it. Obesity. 2006;14(5):737-752.
Pahor M, Blair SN, Espeland M, Fielding R, Gill TM, Guralnik JM, Hadley EC, Kritchevsky SB, Miller ME, Rejeski WJ, et al.
Effects of a physical activity intervention on measures of physical performance: results of the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) Study. J Gerontol A Biol Sci Med Sci. 2006;61A(11):1157-1165.
Underhill HR, Yuan C, Espeland MA, Chen H, Terry JG, Hatsukami TS, Saam T, Tang R, Crouse JR, et al. The composition and morphology of the carotid artery are associated with coronary artery disease: a case-control high resolution magnetic resonance imaging study [abstract]. Circulation. 2006;114(18 Suppl):823-824.
All Publications
For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.
For a list of earlier publications, visit the Carpenter Library Publication Search.