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Mark A. Espeland, Ph.D.Wake Forest School of Medicine

Mark A. Espeland, Ph.D.


Contact Information

Academic: 336-716-2826 | Department: 336-716-2011


Education & Training

  • B.S., Arizona State University-Tempe Campps, 1974
  • Ph.D., University of Rochester, 1981
  • M.A., University of Rochester, 1981


  • American Academy of Neurology
  • Am Assn Of Advancement Of Scie
  • Soc Clin Trials
  • Am Diabetes Assn
  • Am Statistical Assn
  • Biometric Society
Mark A. Espeland, Ph.D.

Mark A. Espeland, Ph.D.

Professor, Biostatistical Sciences
Center on Diabetes, Obesity, and Metabolism

Research Interests

Cognition; Diabetes Mellitus, Type 2; Cognition Disorders; Estrogens, Conjugated (USP); Life Style
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Contact Information

Academic: 336-716-2826 | Department: 336-716-2011


Recent Publications

Long-term effects on cognitive trajectories of postmenopausal hormone therapy in two age groups. Espeland MA, Rapp SR, Manson JE, Goveas JS, Shumaker SA, Hayden KM, Weitlauf JC, Gaussoin SA, Baker LD, Padula CB, Hou L, Resnick SM.. J Gerontol A Biol Sci Med Sci. 2017;72(6):838-845.

Effects of physical activity intervention on physical and cognitive function in sedentary adults with and without diabetes. Espeland MA, Lipska K, Miller ME, Rushing J, Cohen RA, Verghese J, McDermott MM, King AC, Strotmeyer ES, Blair SN, Pahor M, Reid K, Demons J, Kritchevsky SB.. J Gerontol A Biol Sci Med Sci. 2017;72(6):861-866.

Effect of a long-term intensive lifestyle intervention on cognitive function: Action for Health in Diabetes study. Rapp SR, Luchsinger JA, Baker LD, Blackburn GL, Hazuda HP, Demos-McDermott KE, Jeffery RW, Keller JN, McCaffery JM, Pajewski NM, Evans M, Wadden TA, Arnold SE, Espeland MA.. J Am Geriatr Soc. 2017;65(5):966-972.

Objective estimates of physical activity and sedentary time among young adults. Unick JL, Lang W, Tate DF, Bond DS, Espeland MA, Wing RR.. J Obes. 2017;2017():9257564.

Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models. Cacciottolo M, Wang X, Driscoll I, Woodward N, Saffari A, Reyes J, Serre ML, Vizuete W, Sioutas C, Morgan TE, Gatz M, Chui HC, Shumaker SA, Resnick SM, Espeland MA, Finch CE, Chen JC.. Transl Psychiatry. 2017;7(1):e1022.

Head impact exposure in youth football: comparing age- and weight-based levels of play. Kelley ME, Urban JE, Miller LE, Jones DA, Espeland MA, Davenport EM, Whitlow CT, Maldjian JA, Stitzel JD.. J Neurotrauma. 2017;34(11):1939-1947.

Clinical trials targeting aging and age-related multimorbidity. Espeland MA, Crimmins EM, Grossardt BR, Crandall JP, Gelfond JA, Harris TB, Kritchevsky SB, Manson JE, Robinson JG, Rocca WA, Temprosa M, Thomas F, Wallace R, Barzilai N.. J Gerontol A Biol Sci Med Sci. 2017;72(3):355-361.

Cost of intervention delivery in a lifestyle weight loss trial in type 2 diabetes: results from the Look AHEAD clinical trial. Rushing J, Wing R, Wadden TA, Knowler WC, Lawlor M, Evans M, Killean T, Montez M, Espeland MA, Zhang P.. Obes Sci Pract. 2017;3(1):15-24.

Red blood cell polyunsaturated fatty acids and mortality in the Women's Health Initiative Memory Study. Harris WS, Luo J, Pottala JV, Espeland MA, Margolis KL, Manson JE, Wang L, Brasky TM, Robinson JG.. J Clin Lipidol. 2017;11(1):250-259.e5.

Changes in metabolic risk factors over 10 years and their associations with late-life cognitive performance: the Multi-Ethnic Study of Atherosclerosis. Hughes TM, Craft S, Baker LD, Espeland MA, Rapp SR, Sink KM, Bertoni AG, Burke GL, Gottesman RF, Michos ED, Luchsinger JA, Fitzpatrick AL, Hayden KM.. Alzheimers Dement (Amst). 2017;8():18-25.

Social participation modifies the effect of a structured physical activity program on major mobility disability among older adults: results from the LIFE study. Corbett DB, Rejeski WJ, Tudor-Locke C, Glynn NW, Kritchevsky SB, McDermott MM, Church TS, Fielding RA, Gill TM, King AC, Miller ME, Chen H, Pahor M, Manini TM, Pahor M, Guralnik JM, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Lee J,.. J Gerontol B Psychol Sci Soc Sci. 2017;():.

Effect of a long-term intensive lifestyle intervention on prevalence of cognitive impairment. Espeland MA, Luchsinger JA, Baker LD, Neiberg R, Kahn SE, Arnold SE, Wing RR, Blackburn GL, Bray G, Evans M, Hazuda HP, Jeffery RW, Wilson VM, Clark JM, Coday M, Demos-McDermott K, Foreyt JP, Greenway F, Hill JO, Horton ES, Jakicic JM,.. Neurology. 2017;88(21):2026-2035.

Chronic use of aspirin and total white matter lesion volume: results from the Women's Health Initiative Memory Study of Magnetic Resonance Imaging Study. Holcombe A, Ammann E, Espeland MA, Kelley BJ, Manson JE, Wallace R, Robinson J.. J Stroke Cerebrovasc Dis. 2017;26(10):2128-2136.

Dietary outcomes within the study of novel approaches to weight gain prevention (SNAP) randomized controlled trial [abstract]. LaRose JG, Evans EW, Neiberg R, Perdue L, Hatley K, Tate DF, Espeland M, Gorin AA, Lewis CE, Robichaud E, Wing RR.. Ann Behav Med. 2017;51(Suppl 1):S2129-2130.

Erythrocyte omega-3 fatty acids are inversely associated with incident dementia: secondary analyses of longitudinal data from the Women's Health Initiative Memory Study (WHIMS). Ammann EM, Pottala JV, Robinson JG, Espeland MA, Harris WS.. Prostaglandins Leukot Essent Fatty Acids. 2017;121():68-75.

Improvements in cardiovascular risk factors in young adults in a randomized trial of approaches to weight gain prevention. Wing RR, Tate DF, Garcia KR, Bahnson J, Lewis CE, Espeland MA.. Obesity (Silver Spring). 2017;25(10):1660-1666.

ENabling reduction of low-grade inflammation in SEniors Pilot Study: concept, rationale, and design. Manini TM, Anton SD, Beavers DP, Cauley JA, Espeland MA, Fielding RA, Kritchevsky SB, Leeuwenburgh C, Lewis KH, Liu C, McDermott MM, Miller ME, Tracy RP, Walston JD, Radziszewska B, Lu J, Stowe C, Wu S, Newman AB, Ambrosius WT, Pahor M.. J Am Geriatr Soc. 2017;65(9):1961-1968.

Investigating the effects of repetitive head impact exposure in youth football using neurite orientation dispersion and density imaging (NODDI) [abstract]. Whitlow C, Bahrami N, Urban J, Davenport E, Jung Y, Espeland M, Powers A, Stitzel J, Maldjian J.. Brain Inj. 2017;31(6-7):984.

Designing clinical trials with age-related multiple morbidity outcomes [abstract]. Espeland M, Crandall JP, Kritchevsky S, Crimmins EM, Grossardt BR, Bahnson J, Miller ME, Justice JN, Barzilai N.. Trials. 2017;18(Suppl 1):O15.

Long-term impact of weight loss intervention on changes in cognitive function: exploratory analyses from the Action for Health in Diabetes randomized controlled clinical trial. Espeland MA, Carmichael O, Hayden K, Neiberg RH, Newman AB, Keller JN, Wadden TA, Rapp SR, Hill JO, Horton ES, Johnson KC, Wagenknecht L, Wing RR.. J Gerontol A Biol Sci Med Sci. 2017;():.

The cocoa supplement and multivitamin outcomes study in the mind (cosmos-mind): design and rationale [abstract]. Gaussoin S, Espeland MA, Shumaker SA, Rapp SR, Harris D, Pleasants D, Robertson J, Baker LD.. Trials. 2017;18(Suppl 1):P398.

Head impact exposure measured in a single youth football team during practice drills. Kelley ME, Kane JM, Espeland MA, Miller LE, Powers AK, Stitzel JD, Urban JE.. J Neurosurg Pediatr. 2017;20(5):489-497.

Menopausal hormone therapy and long-term all-cause and cause-specific mortality: the Women's Health Initiative randomized trials. Manson JE, Aragaki AK, Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Chlebowski RT, Howard BV, Thomson CA, Margolis KL, Lewis CE, Stefanick ML, Jackson RD, Johnson KC, Martin LW, Shumaker SA, Espeland MA, Wactawski-Wende J.. JAMA. 2017;318(10):927-938.

Objectively assessed physical activity and weight loss maintenance among individuals enrolled in a lifestyle intervention. Unick JL, Gaussoin SA, Hill JO, Jakicic JM, Bond DS, Hellgren M, Johnson KC, Peters A, Coday M, Kitzman DW, Bossart S, Wing RR, Espeland MA, et al.. Obesity (Silver Spring). 2017;25(11):1903-1909.

Long term effect of intensive lifestyle intervention on cerebral blood flow. Espeland MA, Luchsinger JA, Neiberg RH, Carmichael O, Laurienti PJ, Pi-Sunyer X, Wing RR, Cook D, Horton E, Casanova R, Erickson K, Nick Bryan R.. J Am Geriatr Soc. 2017;():.

Negative affect is associated with higher risk of incident cognitive impairment in nondepressed postmenopausal women. Korthauer LE, Goveas J, Espeland MA, Shumaker SA, Garcia KR, Tindle H, Salmoirago-Blotcher E, Sink KM, Vaughan L, Rapp SR, Resnick SM, Driscoll I.. J Gerontol A Biol Sci Med Sci. 2017;():.

Cognitive function and changes in cognitive function as predictors of incident cardiovascular disease: the Women's Health Initiative Memory Study. Leng X, Espeland MA, Manson JE, Stefanick ML, Gower EW, Hayden KM, Limacher MC, Vaughan L, Robinson J, Wallace R, Wassertheil-Smoller S, Yaffe K, Shumaker SA.. J Gerontol A Biol Sci Med Sci. 2017;():.

Global cognitive function before, surrounding, and after ischemic stroke: the role of risk and protective factors varies with time among ischemic stroke survivors. Vaughan L, Bushnell C, Bell CL, Espeland MA.. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2016;23(1):117-131.

Sleep duration, cognitive decline, and dementia risk in older women. Chen JC, Espeland MA, Brunner RL, Lovato LC, Wallace RB, Leng X, Phillips LS, Robinson JG, Kotchen JM, Johnson KC, Manson JE, Stefanick ML, Sarto GE, Mysiw WJ.. Alzheimers Dement. 2016;12(1):21-33.

Longitudinal cognitive trajectories of women Veterans from the Women's Health Initiative Memory Study. Padula CB, Weitlauf JC, Rosen AC, Reiber G, Cochrane BB, Naughton MJ, Li W, Rissling M, Yaffe K, Hunt JR, Stefanick ML, Goldstein MK, Espeland MA.. Gerontologist. 2016;56(1):115-125.

Prospective association of GLUL rs10911021 with cardiovascular morbidity and mortality among individuals with type 2 diabetes: the Look AHEAD Study. Huggins GS, Berkowitz RI, Blackburn GL, Bray GA, Cheskin L, Clark JM, Coday M, Espeland MA, Evans M, Foreyt JP, Glasser S, Greenway FL, Gregg EW, Hanson RL, Hazuda HP, Hill JO, Horton ES, Jakicic JM, Jeffery RW, Johnson KC, Kahn SE, Kitzman DW,.. Diabetes. 2016;65(1):297-302.

Predictors of optimal cognitive aging in 80+ women: the Women's Health Initiative Memory Study. Goveas JS, Rapp SR, Hogan PE, Driscoll I, Tindle HA, Smith JC, Kesler SR, Zaslavsky O, Rossom RC, Ockene JK, Yaffe K, Manson JE, Resnick SM, Espeland MA.. J Gerontol A Biol Sci Med Sci. 2016;71(Suppl 1):S62-S71.

Cost-effectiveness of the LIFE physical activity intervention for older adults at increased risk for mobility disability. Groessl EJ, Kaplan RM, Castro Sweet CM, Church T, Espeland MA, Gill TM, Glynn NW, King AC, Kritchevsky S, Manini T, McDermott MM, Reid KF, Rushing J, Pahor M.. J Gerontol A Biol Sci Med Sci. 2016;71(5):656-662.

Red blood cell fatty acids and incident diabetes mellitus in the Women's Health Initiative Memory Study. Harris WS, Luo J, Pottala JV, Margolis KL, Espeland MA, Robinson JG.. PLoS One. 2016;11(2):e0147894.

The relationship of social support with treatment adherence and weight loss in Latinos with type 2 diabetes. Marquez B, Anderson A, Wing RR, West DS, Newton RL, Meacham M, Hazuda HP, Peters A, Montez MG, Broyles ST, Walker M, Evans-Hudsnall G, Espeland MA, et al.. Obesity (Silver Spring). 2016;24(3):568-575.

Effects of hormone therapy on brain volumes changes of postmenopausal women revealed by optimally-discriminative voxel-based morphometry. Zhang T, Casanova R, Resnick SM, Manson JE, Baker LD, Padual CB, Kuller LH, Bryan RN, Espeland MA, Davatzikos C.. PLoS One. 2016;11(3):e0150834.

Obesity and structural brain integrity in older women: the Women's Health Initiative Magnetic Resonance Imaging Study. Driscoll I, Gaussoin SA, Wassertheil-Smoller S, Limacher M, Casanova R, Yaffe K, Resnick SM, Espeland MA.. J Gerontol A Biol Sci Med Sci. 2016;71(9):1216-1222.

Impact of intensive lifestyle intervention on preference-based quality of life in type 2 diabetes: results from the Look AHEAD trial. Zhang P, Hire D, Espeland MA, Knowler WC, Thomas S, Tsai AG, Glick HA.. Obesity (Silver Spring). 2016;24(4):856-864.

Abnormalities in diffusional kurtosis metrics related to head impact exposure in a season of high school varsity football. Davenport EM, Apkarian K, Whitlow CT, Urban JE, Jensen JH, Szuch E, Espeland MA, Jung Y, Rosenbaum DA, Gioia G, Powers AK, Stitzel JD, Maldjian JA.. J Neurotrauma. 2016;33(23):2133-2146.

Innovative self-regulation strategies to reduce weight gain in young adults: the Study of Novel Approaches to Weight Gain Prevention (SNAP) randomized clinical trial. Wing RR, Tate DF, Espeland MA, Lewis CE, LaRose JG, Gorin AA, Bahnson J, Perdue LH, Hatley KE, Ferguson E, Garcia KR, Lang W.. JAMA Intern Med. 2016;176(6):755-762.

The evolution of the WHI 80+ cohort. Beavers DP, Pettinger M, Espeland MA, Snively BM, Leng X, Hunt JR, Tindle HA, Shumaker SA.. J Gerontol A Biol Sci Med Sci. 2016;71(Suppl 1):S13-S22.

Brain and white matter hyperintensity volumes after 10 years of random assignment to lifestyle intervention. Espeland MA, Erickson K, Neiberg RH, Jakicic JM, Wadden TA, Wing RR, Desiderio L, Erus G, Hsieh MK, Davatzikos C, Maschak-Carey BJ, Laurienti PJ, Demos-McDermott K, Bryan RN.. Diabetes Care. 2016;39(5):764-771.

Metformin as a tool to target aging. Barzilai N, Crandall JP, Kritchevsky SB, Espeland MA.. Cell Metab. 2016;23(6):1060-1065.

Recruitment of young adults for weight gain prevention: randomized comparison of direct mail strategies. Crane MM, LaRose JG, Espeland MA, Wing RR, Tate DF.. Trials. 2016;17(1):282.

Changes in regional body composition over 8 years in a randomized lifestyle trial: the Look AHEAD study. Pownall HJ, Schwartz AV, Bray GA, Berkowitz RI, Lewis CE, Boyko EJ, Jakicic JM, Chen H, Heshka S, Gregg EW, Johnson KC, Espeland M.. Obesity (Silver Spring). 2016;24(9):1899-1905.

Impact of moderate physical activity on the longitudinal trajectory of a cardiac specific biomarker of injury: results from a randomized pilot study of exercise intervention. deFilippi CR, de Lemos JA, Newman AB, Guralnik JM, Christenson RH, Pahor M, Church T, Espeland M, Krithevsky SB [sic] [Kritchevsky SB], Stafford R, Seliger SL.. Am Heart J. 2016;179():151-156.

Relative differences in resting-state brain connectivity associated with long term intensive lifestyle intervention. Casanova R, Hayasaka S, Saldana S, Bryan NR, Demos KE, Desiderio L, Erickson KI, Espeland MA, Nasrallah IM, Wadden T, Laurienti PJ.. Psychoneuroendocrinology. 2016;74():231-239.

Relationships between caffeine intake and risk for probable dementia or global cognitive impairment: the Women's Health Initiative Memory Study. Driscoll I, Shumaker SA, Snively BM, Margolis KL, Manson JE, Vitolins MZ, Rossom RC, Espeland MA.. J Gerontol A Biol Sci Med Sci. 2016;71(12):1596-1602.

Sex biology contributions to vulnerability to Alzheimer's disease: a think tank convened by the Women's Alzheimer's Research Initiative. Snyder HM, Asthana S, Bain L, Brinton R, Craft S, Dubal DB, Espeland MA, Gatz M, Mielke MM, Raber J, Rapp PR, Yaffe K, Carrillo MC.. Alzheimers Dement. 2016;12(11):1186-1196.

Association of weight loss maintenance and weight regain on 4-year changes in CVD risk factors: the Action for Health in Diabetes (Look AHEAD) Clinical Trial. Wing RR, Espeland MA, Clark JM, Hazuda HP, Knowler WC, Pownall HJ, Unick J, Wadden T, Wagenknecht L.. Diabetes Care. 2016;39(8):1345-1355.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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