Profile

Carlos M. Ferrario, M.D.Wake Forest School of Medicine

Carlos M. Ferrario, M.D.

Professor,


Contact Information

Academic: 336-716-5849 | Department: 336-716-5849

Email: cferrari@wakehealth.edu

Additional Languages

Italian, Spanish

Education & Training

  • B.A., Mariano Moreno College-Argentina, 1956
  • M.D., Univ Buenos Aires Faculty of Med-Argentina, 1963
  • Internship, Italian Hospital Buenos Aires-, 1963
  • Residency, Italian Hospital Buenos Aires-, 1965
  • Fellowship, Univ Goteborg Med Fac-Sweden, 1965
  • Fellowship, Karolinska Institute-Sweden, 1966
  • Fellowship, Cleveland Clinic Foundation, 1969

Memberships

  • Int'L Society Of Angiology
  • Int'L Society Of Hypertension
  • Int'L Society On Hypertension
  • Nat'L Heart Lung & Blood Inst
  • Am Heart Association
  • Am Physiological Society
  • Assn Of Black Cardiologists
Carlos M. Ferrario, M.D.

Carlos M. Ferrario, M.D.

Professor, Surgery, General
Office of Women in Medicine and Science
Physiology & Pharmacology

Research Interests

cardiac function, hormones/cytokines/signalling, hypertension, temporary, transgenics

Contact Information

Academic: 336-716-5849 | Department: 336-716-5849

Email: cferrari@wakehealth.edu

Recent Publications

Ferrario CM, Schiffrin EL. Role of mineralocorticoid receptor antagonists in cardiovascular disease. Circ Res. 2015;116(1):206-213.

Zhou P, Cheng CP, Li T, Ferrario CM, Cheng HJ. Modulation of cardiac L-type Ca2+ current by angiotensin-(1-7): normal versus heart failure. Ther Adv Cardiovasc Dis. 2015;():.

Nagata S, Varagic J, Kon ND, Wang H, Groban L, Simington SW, Ahmad S, Dell'Italia LJ, VonCannon JL, Deal D, Ferrario CM. Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue. Ther Adv Cardiovasc Dis. 2015;():.

Varagic J, Ahmad S, Nagata S, Ferrario CM. ACE2: angiotensin II/angiotensin-(1-7) balance in cardiac and renal injury. Curr Hypertens Rep. 2014;16(3):420.

Ahmad S, Varagic J, Groban L, Dell'italia LJ, Nagata S, Kon ND, Ferrario CM. Angiotensin-(1-12): a chymase-mediated cellular angiotensin II substrate. Curr Hypertens Rep. 2014;16(5):429.

Joyner J, Cline DM, Simmons DR, Ferrario CM, Mount DL. Self-reported cardiovascular disease risk factors and associated hopelessness in African American participants of a church-placed health screening program. Ethn Dis. 2014;24(1):60-66.

Ferrario CM, Ahmad S, Nagata S, Simington SW, Varagic J, Kon N, Dell'italia LJ. An evolving story of angiotensin-II-forming pathways in rodents and humans. Clin Sci. 2014;126(7-8):461-469.

Habibi J, Hayden MR, Ferrario CM, Sowers JR, Whaley-Connell AT. Salt loading promotes kidney injury via fibrosis in young female Ren2 rats. Cardiorenal Med. 2014;4(1):43-52.

Zheng J, Wei CC, Hase N, Shi K, Killingsworth CR, Litovsky SH, Powell PC, Kobayashi T, Ferrario CM, Rab A, Aban I, Collawn JF, Dell'Italia LJ. Chymase mediates injury and mitochondrial damage in cardiomyocytes during acute ischemia/reperfusion in the dog. PLoS One. 2014;9(4):e94732.

Flores-Monroy J, Ferrario CM, Valencia-Hernandez I, Hernandez-Campos ME, Martinez-Aguilar L. Comparative effects of a novel angiotensin-converting enzyme inhibitor versus captopril on plasma angiotensins after myocardial infarction. Pharmacology. 2014;94(1-2):21-28.

Schindler C, Guenther K, Hermann C, Ferrario CM, Schroeder C, Haufe S, Jordan J, Kirch W. Statin treatment in hypercholesterolemic men does not attenuate angiotensin II-induced venoconstriction. PLoS One. 2014;9(9):e103909.

Varagic J, Punzi H, Ferrario CM. Clinical utility of fixed-dose combinations in hypertension: evidence for the potential of nebivolol/valsartan. Integr Blood Press Control. 2014;7():61-70.

Varagic J, VonCannon JL, Nagata S, Ahmad S, Ferrario CM. Human Ang-(1-12) and hemodynamic and cardiac biometrics in rats overexpressing human angiotensinogen [abstract]. Hypertension. 2014;64(Suppl 1):A477.

Ahmad S, VonCannon JL, Bader M, Delbruck M, Varagic J, Ferrario CM. Chymase-mediated angiotensin II formation in the heart of rats overexpressing the human angiotensinogen gene [abstract]. Hypertension. 2014;64(Suppl 1):A621.

Ahmad S, Varagic J, VonCannon JL, Dell'Italia LJ, Groban L, Ferrario CM. Angiotensin-(1-12) is a better substrate compared to angiotensin I to generate angiotensin Ii by rat chymase [abstract]. Hypertension. 2014;64(Suppl 1):A622.

Moniwa N, Varagic J, Ahmad S, Voncannon JL, Simington SW, Wang H, Groban L, Brosnihan KB, Nagata S, Kato J, Kitamura K, Gomez RA, Lopez ML, Ferrario CM. Hemodynamic and hormonal changes to dual Renin-Angiotensin system inhibition in experimental hypertension. Hypertension. 2013;61(2):417-424.

Varagic J, Ahmad S, VonCannon JL, Moniwa N, Brosnihan KB, Wysocki J, Batlle D, Ferrario CM. Predominance of AT(1) blockade over mas-mediated angiotensin-(1-7) mechanisms in the regulation of blood pressure and renin-angiotensin system in mRen2.Lewis rats. Am J Hypertens. 2013;26(5):583-590.

Ahmad S, Wei CC, Tallaj J, Dell'Italia LJ, Moniwa N, Varagic J, Ferrario CM. Chymase mediates angiotensin-(1-12) metabolism in normal human hearts. J Am Soc Hypertens. 2013;7(2):128-136.

Joyner J, Simmons DR, Moore MA, Ferrario CM, Forrest B, Carmouche D. Louisiana cardiometabolic risk factor disparities provide opportunities for improvement [abstract]. In: Abstracts of the Xavier University of Louisiana College of Pharmacy Sixth Health Disparities Conference; 2013 Mar 7-9; New Orleans (LA). 2013;():46.

Dell'Italia LJ, Ferrario CM. The never-ending story of angiotensin peptides: beyond angiotensin I and II [editorial]. Circ Res. 2013;112(8):1086-1087.

Whaley-Connell A, Habibi J, Rehmer N, Ardhanari S, Hayden MR, Pulakat L, Krueger C, Ferrario CM, DeMarco VG, Sowers JR. Renin inhibition and AT1R blockade improve metabolic signaling, oxidant stress and myocardial tissue remodeling. Metabolism. 2013;62(6):861-872.

Ferrario CM, Joyner J, Colby C, Exuzides A, Moore M, Simmons D, Bestermann W Jr, Frech-Tamas F. The COSEHC Global Vascular Risk Management quality improvement program: first follow-up report. Vasc Health Risk Manag. 2013;9():391-400.

Ferrario CM, Panjabi S, Buzinec P, Swindle JP. Clinical and economic outcomes associated with amlodipine/renin-angiotensin system blocker combinations. Ther Adv Cardiovasc Dis. 2013;7(1):27-39.

Wang H, Jessup JA, Zhao Z, Da Silva J, Lin M, Macnamara LM, Ahmad S, Chappell MC, Ferrario CM, Groban L. Characterization of the cardiac renin angiotensin system in oophorectomized and estrogen-replete mRen2.Lewis rats. PLoS One. 2013;8(10):e76992.

Ferrario CM, Jessup JA, Smith RD. Hemodynamic and hormonal patterns of untreated essential hypertension in men and women. Ther Adv Cardiovasc Dis. 2013;7(6):293-305.

Groban L, Wang H, Zhao Z, Jessup J, Lin M, MacNamara L, Ferrario CM. Estrogen replacement downregulates cardiac angiotensin II in an ACE-independent manner in oophorectomized mRen2.Lewis rats [abstract]. In: Abstracts of the 2013 Annual Meeting of the American Society of Anesthesiologists (ASA); 2013 Oct 12-16; San Francisco (CA). 2013;():A5002.

Whaley-Connell AT, Habibi J, Aroor A, Ma L, Hayden MR, Ferrario CM, Demarco VG, Sowers JR. Salt loading exacerbates diastolic dysfunction and cardiac remodeling in young female Ren2 rats. Metabolism. 2013;62(12):1761-1771.

Wang H, Zhao Z, Jessup J, Lin M, MacNamara L, Ahmad S, Ferrario C, Groban L. Estrogen replacement downregulates cardiac angiotensin II in an ACE-independent manner in oophorectomized mRen2.Lewis rats [abstract]. Circ Res. 2013;113(4 Suppl):A086.

Moniwa N, Varagic J, Simington SW, Ahmad S, Nagata S, Voncannon JL, Ferrario CM. Primacy of angiotensin converting enzyme in angiotensin-(1-12) metabolism. Am J Physiol Heart Circ Physiol. 2013;305(5):H644-H650.

Moniwa N, Varagic J, Nagata S, Ahmad S, Simington SW, VonCannon JL, Shimamura Y, Hasegawa K, Takizawa H, Ura N, Tanaka S, Furuhashi M, Yoshida H, Miura T, Ferrario CM. Renin independent Ang-(1-12) production in both the systemic and coronary circulation [abstract]. Hypertension. 2013;62(3 Suppl):604.

Nagata S, Varagic J, Simington SW, Ahmad S, VonCannon JL, Wang H, Groban L, Kon ND, Dell'Italia LJ, Ferrario CM. Differential expression of angiotensin-(1-12)/chymase in human atrial tissue [abstract]. Hypertension. 2013;62(3 Suppl):629.

Nagata S, Varagic J, Simington SW, Ahmad S, VonCannon JL, Wang H, Kon ND, Dell'Italia LJ, Ferrario CM, Groban L. Does cardiac ang-(1-12) have a role in sex-specific heart disease? [abstract]. Hypertension. 2013;62(3 Suppl):632.

Whaley-Connell AT, Habibi J, Nistala R, DeMarco VG, Pulakat L, Hayden MR, Joginpally T, Ferrario CM, Parrish AR, Sowers JR. Mineralocorticoid receptor-dependent proximal tubule injury is mediated by a redox-sensitive mTOR/S6K1 pathway. Am J Nephrol. 2012;35(1):90-100.

Moniwa N, Varagic J, Ahmad S, VonCannon JL, Ferrario CM. Restoration of the blood pressure circadian rhythm by direct renin inhibition and blockade of angiotensin II receptors in mRen2.Lewis hypertensive rats. Ther Adv Cardiovasc Dis. 2012;6(1):15-29.

Moniwa N, Varagic J, Ahmad S, Ferrario CM. Effects of combination therapy with valsartan and aliskiren on arterial pressure, cardiac hypertrophy and urinary protein excretion in hypertensive rats [abstract]. FASEB J. 2012;26(Meeting Abstracts):1105.4.

Whaley-Connell A, Habibi J, Nistala R, Hayden MR, Pulakat L, Sinak C, Locher B, Ferrario CM, Sowers JR. Combination of direct renin inhibition with angiotensin type 1 receptor blockade improves aldosterone but does not improve kidney injury in the transgenic Ren2 rat. Regul Pept. 2012;176(1-3):36-44.

Ma L, Gul R, Habibi J, Yang M, Pulakat L, Whaley-Connell A, Ferrario CM, Sowers JR. Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the transgenic (mRen2) rat. Am J Physiol Heart Circ Physiol. 2012;302(11):H2341-51.

Moniwa N, Wei C-C, Dell'Italia LJ, Ferrario CM, Ahmad S, Varagic J. Chymase-mediated angiotensin II generation from angiotensin-(1-12) in left ventricular tissue of normal and diseased human subjects [abstract]. J Clin Hypertens (Greenwich). 2012;14(Suppl 1):149.

Whaley-Connell A, Habibi J, Nistala R, Hayden MR, Pulakat L, Ferrario CM, Sowers JR. Combination direct renin inhibition with angiotensin type 1 receptor blockade improves aldosterone but does not improve kidney injury in the transgenic Ren2 rat [abstract]. J Clin Hypertens (Greenwich). 2012;14(Suppl 1):229.

Joyner J, Simmons DR, Moore MA, Ferrario CM, Carmouche D. Working with a payer to improve outcomes through a COSEHC CQI project and NCQA diabetes recognition assessment [abstract]. J Clin Hypertens (Greenwich). 2012;14(Suppl 1):236.

Velasquez-Mieyer PA, Neira CP, Joyner J, Simpson-O'Reggio A, Garcia T, Simmons DR, Ferrario CM. Age best predicts undiagnosed hypertension in children at high-risk for cardiovascular disease (CVD) [abstract]. J Clin Hypertens (Greenwich). 2012;14(Suppl 1):248.

Varagic J, Ahmad S, Voncannon JL, Moniwa N, Simington SW Jr, Brosnihan BK, Gallagher PE, Habibi J, Sowers JR, Ferrario CM. Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded spontaneously hypertensive rats. J Hypertens. 2012;30(9):1766-1774.

Wei C-C, Chen Y, Powell LC, Zheng J, Shi K, Bradley WE, Powell PC, Ahmad S, Ferrario CM, Dell'Italia LJ. Cardiac kallikrein-kinin system is upregulated in chronic volume overload and mediates an inflammatory induced collagen loss. PLoS One. 2012;7(6):e40110.

Joyner J, Moore AR, Mount DL, Simmons DR, Ferrario CM, Cline DM. Emergency department patients self-report higher patient inertia, hopelessness, and harmful lifestyle choices than community counterparts. J Clin Hypertens (Greenwich). 2012;14(12):828-835.

Moniwa N, Varagic J, Ahmad S, Ferrario CM. Differential effects of ACE and chymase in the metabolism of exogenous angiotensin-(1-12) in Wistar-Kyoto rats [abstract]. FASEB J. 2012;26(Meeting Abstracts Suppl):1105.3.

Groban L, Wang H, Machado FSM, Trask AJ, Kritchevsky SB, Ferrario CM, Diz DI. Low glial angiotensinogen improves body habitus, diastolic function, and exercise tolerance in aging male rats. Cardiovasc Endocrinol. 2012;1(3):49-58.

Ferrario CM. Hypertension and dyslipidemia. Relationship between angiotensin II and cholesterol in atherogenesis [Spanish] In: Esper RJ, Vilarino JO, eds. Cardiovascular Diabetology. Paraguay;2012: 175-187.

Moniwa N, Ahmad S, VonCannon JL, Simington SW, Varagic J, Ferrario CM. Role of angiotensin converting enzyme on the production of angiotensins from angiotensin-(1-12) in normotensive Winstar-kyoto rats and spontaneously hypertensive rats [abstract]. Hypertension. 2012;60(3 Suppl):235.

Varagic J, Ahmad S, Moniwa N, Brosnihan KB, Wysocki J, Batlle D, Ferrario CM. Predominance of angiotensin II type 1 receptor blockade over antiotensin-(1-7) mechanisms in the regulation of blood pressure and renin angiotensin system in mRen.Lewis rats [abstract]. Hypertension. 2012;60(Suppl 3):283.

Simington SW, Moniwa N, Ahmad S, VonCannon JL, Dell'Italia LJ, Varagic J, Ferrario CM. Renin does not participate in the production of plasma ang-(1-12) from angiotensinogen [abstract]. Hypertension. 2012;60(3 Suppl):628.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Surgery, General

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