Carlos M. Ferrario, M.D.Wake Forest School of Medicine

Carlos M. Ferrario, M.D.


Contact Information

Academic: 336-716-5849 | Department: 336-716-5849


Additional Languages

Italian, Spanish

Education & Training

  • B.A., Mariano Moreno College-Argentina, 1956
  • M.D., Univ Buenos Aires Faculty of Med-Argentina, 1963
  • Internship, Italian Hospital Buenos Aires-, 1963
  • Residency, Italian Hospital Buenos Aires-, 1965
  • Fellowship, Univ Goteborg Med Fac-Sweden, 1965
  • Fellowship, Karolinska Institute-Sweden, 1966
  • Fellowship, Cleveland Clinic Foundation, 1969


  • Int'L Society Of Angiology
  • Int'L Society Of Hypertension
  • Int'L Society On Hypertension
  • Nat'L Heart Lung & Blood Inst
  • Am Heart Association
  • Am Physiological Society
  • Assn Of Black Cardiologists
Carlos M. Ferrario, M.D.

Carlos M. Ferrario, M.D.

Professor, Surgery, General
Office of Women in Medicine and Science
Physiology & Pharmacology

Research Interests

Hypertension; Peptide Fragments; Angiotensin I; Angiotensin II; Renin-Angiotensin System
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Contact Information

Academic: 336-716-5849 | Department: 336-716-5849


Recent Publications

Increased fibroblast chymase production mediates procollagen autophagic digestion in volume overload. Fu L, Wei CC, Powell PC, Bradley WE, Ahmad S, Ferrario CM, Collawn JF, Dell'Italia LJ.. J Mol Cell Cardiol. 2016;92():1-9.

Cardiac angiotensin-(1-12) expression and systemic hypertension in rats expressing the human angiotensinogen gene. Ferrario CM, VonCannon JL, Jiao Y, Ahmad S, Bader M, Dell'Italia LJ, Groban L, Varagic J.. Am J Physiol Heart Circ Physiol. 2016;310(8):H995-H1002.

Mast cell inhibition attenuates cardiac remodeling and diastolic dysfunction in middle-aged, ovariectomized Fischer 344 x Brown Norway rats. Wang H, da Silva J, Alencar A, Zapata-Sudo G, Lin MS, Sun X, Ahmad S, Ferrario CM, Groban L.. J Cardiovasc Pharmacol. 2016;68(1):49-57.

Effect of age, estrogen status, and late-life GPER activation on cardiac structure and function in the Fischer344xBrown Norway female rat. Alencar AK, da Silva JS, Lin M, Silva AM, Sun X, Ferrario CM, Cheng C, Sudo RT, Zapata-Sudo G, Wang H, Groban L.. J Gerontol A Biol Sci Med Sci. 2016;():.

Cardiac remodelling and RAS inhibition. Ferrario CM.. Ther Adv Cardiovasc Dis. 2016;10(3):162-171.

Intracrine angiotensin II functions originate from noncanonical pathways in the human heart. Ferrario CM, Ahmad S, Varagic J, Cheng CP, Groban L, Wang H, Collawn JF, Dell'Italia LJ.. Am J Physiol Heart Circ Physiol. 2016;311(2):H404-H414.

Preface [editorial]. Ferrario CM, Wang JG.. Ther Adv Cardiovasc Dis. 2016;10(3):116-117.

Primacy of cardiac chymase over angiotensin converting enzyme as an angiotensin-(1-12) metabolizing enzyme. Ahmad S, Varagic J, VonCannon JL, Groban L, Collawn JF, Dell'Italia LJ, Ferrario CM.. Biochem Biophys Res Commun. 2016;478(2):559-564.

Intracellular angiotensin-(1-12) changes the electrical properties of intact cardiac muscle. De Mello WC, Dell'Itallia LJ, Varagic J, Ferrario CM.. Mol Cell Biochem. 2016;422(1-2):31-40.

Role of mineralocorticoid receptor antagonists in cardiovascular disease. Ferrario CM, Schiffrin EL.. Circ Res. 2015;116(1):206-213.

Modulation of cardiac L-type Ca2+ current by angiotensin-(1-7): normal versus heart failure. Zhou P, Cheng CP, Li T, Ferrario CM, Cheng HJ.. Ther Adv Cardiovasc Dis. 2015;9(6):342-353.

Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue. Nagata S, Varagic J, Kon ND, Wang H, Groban L, Simington SW, Ahmad S, Dell'Italia LJ, VonCannon JL, Deal D, Ferrario CM.. Ther Adv Cardiovasc Dis. 2015;9(4):168-180.

Renin-angiotensin-aldosterone system gender differences in an Afro-Caribbean population. Cohall DH, Scantlebury-Manning T, James S, Hall K, Ferrario CM.. J Renin Angiotensin Aldosterone Syst. 2015;16(3):539-546.

Functional significance of the chymase/ang-(1-12) pathway on cardiomyocytes [abstract]. Zhang X, Li T, Ahmad S, Varagic J, Groban L, Dell'Italia LJ, Cheng C-P, Ferrario CM.. Hypertension. 2015;66(Suppl 1):A078.

ACE2: angiotensin II/angiotensin-(1-7) balance in cardiac and renal injury. Varagic J, Ahmad S, Nagata S, Ferrario CM.. Curr Hypertens Rep. 2014;16(3):420.

Angiotensin-(1-12): a chymase-mediated cellular angiotensin II substrate. Ahmad S, Varagic J, Groban L, Dell'italia LJ, Nagata S, Kon ND, Ferrario CM.. Curr Hypertens Rep. 2014;16(5):429.

Self-reported cardiovascular disease risk factors and associated hopelessness in African American participants of a church-placed health screening program. Joyner J, Cline DM, Simmons DR, Ferrario CM, Mount DL.. Ethn Dis. 2014;24(1):60-66.

An evolving story of angiotensin-II-forming pathways in rodents and humans. Ferrario CM, Ahmad S, Nagata S, Simington SW, Varagic J, Kon N, Dell'italia LJ.. Clin Sci. 2014;126(7-8):461-469.

Salt loading promotes kidney injury via fibrosis in young female Ren2 rats. Habibi J, Hayden MR, Ferrario CM, Sowers JR, Whaley-Connell AT.. Cardiorenal Med. 2014;4(1):43-52.

Chymase mediates injury and mitochondrial damage in cardiomyocytes during acute ischemia/reperfusion in the dog. Zheng J, Wei CC, Hase N, Shi K, Killingsworth CR, Litovsky SH, Powell PC, Kobayashi T, Ferrario CM, Rab A, Aban I, Collawn JF, Dell'Italia LJ.. PLoS One. 2014;9(4):e94732.

Comparative effects of a novel angiotensin-converting enzyme inhibitor versus captopril on plasma angiotensins after myocardial infarction. Flores-Monroy J, Ferrario CM, Valencia-Hernandez I, Hernandez-Campos ME, Martinez-Aguilar L.. Pharmacology. 2014;94(1-2):21-28.

Statin treatment in hypercholesterolemic men does not attenuate angiotensin II-induced venoconstriction. Schindler C, Guenther K, Hermann C, Ferrario CM, Schroeder C, Haufe S, Jordan J, Kirch W.. PLoS One. 2014;9(9):e103909.

Clinical utility of fixed-dose combinations in hypertension: evidence for the potential of nebivolol/valsartan. Varagic J, Punzi H, Ferrario CM.. Integr Blood Press Control. 2014;7():61-70.

Human Ang-(1-12) and hemodynamic and cardiac biometrics in rats overexpressing human angiotensinogen [abstract]. Varagic J, VonCannon JL, Nagata S, Ahmad S, Ferrario CM.. Hypertension. 2014;64(Suppl 1):A477.

Chymase-mediated angiotensin II formation in the heart of rats overexpressing the human angiotensinogen gene [abstract]. Ahmad S, VonCannon JL, Bader M, Delbruck M, Varagic J, Ferrario CM.. Hypertension. 2014;64(Suppl 1):A621.

Angiotensin-(1-12) is a better substrate compared to angiotensin I to generate angiotensin Ii by rat chymase [abstract]. Ahmad S, Varagic J, VonCannon JL, Dell'Italia LJ, Groban L, Ferrario CM.. Hypertension. 2014;64(Suppl 1):A622.

Hemodynamic and hormonal changes to dual Renin-Angiotensin system inhibition in experimental hypertension. Moniwa N, Varagic J, Ahmad S, Voncannon JL, Simington SW, Wang H, Groban L, Brosnihan KB, Nagata S, Kato J, Kitamura K, Gomez RA, Lopez ML, Ferrario CM.. Hypertension. 2013;61(2):417-424.

Predominance of AT(1) blockade over mas-mediated angiotensin-(1-7) mechanisms in the regulation of blood pressure and renin-angiotensin system in mRen2.Lewis rats. Varagic J, Ahmad S, VonCannon JL, Moniwa N, Brosnihan KB, Wysocki J, Batlle D, Ferrario CM.. Am J Hypertens. 2013;26(5):583-590.

Chymase mediates angiotensin-(1-12) metabolism in normal human hearts. Ahmad S, Wei CC, Tallaj J, Dell'Italia LJ, Moniwa N, Varagic J, Ferrario CM.. J Am Soc Hypertens. 2013;7(2):128-136.

Louisiana cardiometabolic risk factor disparities provide opportunities for improvement [abstract]. Joyner J, Simmons DR, Moore MA, Ferrario CM, Forrest B, Carmouche D.. In: Abstracts of the Xavier University of Louisiana College of Pharmacy Sixth Health Disparities Conference; 2013 Mar 7-9; New Orleans (LA). 2013;():46.

The never-ending story of angiotensin peptides: beyond angiotensin I and II [editorial]. Dell'Italia LJ, Ferrario CM.. Circ Res. 2013;112(8):1086-1087.

Renin inhibition and AT1R blockade improve metabolic signaling, oxidant stress and myocardial tissue remodeling. Whaley-Connell A, Habibi J, Rehmer N, Ardhanari S, Hayden MR, Pulakat L, Krueger C, Ferrario CM, DeMarco VG, Sowers JR.. Metabolism. 2013;62(6):861-872.

The COSEHC Global Vascular Risk Management quality improvement program: first follow-up report. Ferrario CM, Joyner J, Colby C, Exuzides A, Moore M, Simmons D, Bestermann W Jr, Frech-Tamas F.. Vasc Health Risk Manag. 2013;9():391-400.

Clinical and economic outcomes associated with amlodipine/renin-angiotensin system blocker combinations. Ferrario CM, Panjabi S, Buzinec P, Swindle JP.. Ther Adv Cardiovasc Dis. 2013;7(1):27-39.

Characterization of the cardiac renin angiotensin system in oophorectomized and estrogen-replete mRen2.Lewis rats. Wang H, Jessup JA, Zhao Z, Da Silva J, Lin M, Macnamara LM, Ahmad S, Chappell MC, Ferrario CM, Groban L.. PLoS One. 2013;8(10):e76992.

Hemodynamic and hormonal patterns of untreated essential hypertension in men and women. Ferrario CM, Jessup JA, Smith RD.. Ther Adv Cardiovasc Dis. 2013;7(6):293-305.

Estrogen replacement downregulates cardiac angiotensin II in an ACE-independent manner in oophorectomized mRen2.Lewis rats [abstract]. Groban L, Wang H, Zhao Z, Jessup J, Lin M, MacNamara L, Ferrario CM.. In: Abstracts of the 2013 Annual Meeting of the American Society of Anesthesiologists (ASA); 2013 Oct 12-16; San Francisco (CA). 2013;():A5002.

Salt loading exacerbates diastolic dysfunction and cardiac remodeling in young female Ren2 rats. Whaley-Connell AT, Habibi J, Aroor A, Ma L, Hayden MR, Ferrario CM, Demarco VG, Sowers JR.. Metabolism. 2013;62(12):1761-1771.

Estrogen replacement downregulates cardiac angiotensin II in an ACE-independent manner in oophorectomized mRen2.Lewis rats [abstract]. Wang H, Zhao Z, Jessup J, Lin M, MacNamara L, Ahmad S, Ferrario C, Groban L.. Circ Res. 2013;113(4 Suppl):A086.

Primacy of angiotensin converting enzyme in angiotensin-(1-12) metabolism. Moniwa N, Varagic J, Simington SW, Ahmad S, Nagata S, Voncannon JL, Ferrario CM.. Am J Physiol Heart Circ Physiol. 2013;305(5):H644-H650.

Renin independent Ang-(1-12) production in both the systemic and coronary circulation [abstract]. Moniwa N, Varagic J, Nagata S, Ahmad S, Simington SW, VonCannon JL, Shimamura Y, Hasegawa K, Takizawa H, Ura N, Tanaka S, Furuhashi M, Yoshida H, Miura T, Ferrario CM.. Hypertension. 2013;62(3 Suppl):604.

Differential expression of angiotensin-(1-12)/chymase in human atrial tissue [abstract]. Nagata S, Varagic J, Simington SW, Ahmad S, VonCannon JL, Wang H, Groban L, Kon ND, Dell'Italia LJ, Ferrario CM.. Hypertension. 2013;62(3 Suppl):629.

Does cardiac ang-(1-12) have a role in sex-specific heart disease? [abstract]. Nagata S, Varagic J, Simington SW, Ahmad S, VonCannon JL, Wang H, Kon ND, Dell'Italia LJ, Ferrario CM, Groban L.. Hypertension. 2013;62(3 Suppl):632.

Mineralocorticoid receptor-dependent proximal tubule injury is mediated by a redox-sensitive mTOR/S6K1 pathway. Whaley-Connell AT, Habibi J, Nistala R, DeMarco VG, Pulakat L, Hayden MR, Joginpally T, Ferrario CM, Parrish AR, Sowers JR.. Am J Nephrol. 2012;35(1):90-100.

Restoration of the blood pressure circadian rhythm by direct renin inhibition and blockade of angiotensin II receptors in mRen2.Lewis hypertensive rats. Moniwa N, Varagic J, Ahmad S, VonCannon JL, Ferrario CM.. Ther Adv Cardiovasc Dis. 2012;6(1):15-29.

Effects of combination therapy with valsartan and aliskiren on arterial pressure, cardiac hypertrophy and urinary protein excretion in hypertensive rats [abstract]. Moniwa N, Varagic J, Ahmad S, Ferrario CM.. FASEB J. 2012;26(Meeting Abstracts):1105.4.

Combination of direct renin inhibition with angiotensin type 1 receptor blockade improves aldosterone but does not improve kidney injury in the transgenic Ren2 rat. Whaley-Connell A, Habibi J, Nistala R, Hayden MR, Pulakat L, Sinak C, Locher B, Ferrario CM, Sowers JR.. Regul Pept. 2012;176(1-3):36-44.

Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the transgenic (mRen2) rat. Ma L, Gul R, Habibi J, Yang M, Pulakat L, Whaley-Connell A, Ferrario CM, Sowers JR.. Am J Physiol Heart Circ Physiol. 2012;302(11):H2341-51.

Chymase-mediated angiotensin II generation from angiotensin-(1-12) in left ventricular tissue of normal and diseased human subjects [abstract]. Moniwa N, Wei C-C, Dell'Italia LJ, Ferrario CM, Ahmad S, Varagic J.. J Clin Hypertens (Greenwich). 2012;14(Suppl 1):149.

Combination direct renin inhibition with angiotensin type 1 receptor blockade improves aldosterone but does not improve kidney injury in the transgenic Ren2 rat [abstract]. Whaley-Connell A, Habibi J, Nistala R, Hayden MR, Pulakat L, Ferrario CM, Sowers JR.. J Clin Hypertens (Greenwich). 2012;14(Suppl 1):229.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Surgery, General

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