Mark John Ferris, Ph.D.Wake Forest School of Medicine

Mark John Ferris, Ph.D.

Assistant Professor,

Contact Information

Academic: 336-716-8620 | Department: 336-716-2011


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Education & Training

  • B.A., University of North Carolina-Greensboro, 2002
  • M.A., University of South Carolina-Columbia, 2005
  • Ph.D., University of South Carolina-Columbia, 2007


  • Society for Neuroscience
Mark John Ferris, Ph.D.

Mark John Ferris, Ph.D.

Assistant Professor, Physiology & Pharmacology

Research Interests

aids, drugs/therapeutic agents pharm, neurosciences/behavior, substance abuse

Contact Information

Academic: 336-716-8620 | Department: 336-716-2011


Related Links

Recent Publications

Luderman KD, Chen R, Ferris MJ, Jones SR, Gnegy ME. Protein kinase C beta regulates the D2-like dopamine autoreceptor. Neuropharmacology. 2015;89():335-341.

Yorgason JT, Rose JH, McIntosh JM, Ferris MJ, Jones SR. Greater ethanol inhibition of presynaptic dopamine release in C57BL/6J than DBA/2J mice: role of nicotinic acetylcholine receptors. Neuroscience. 2015;284():854-864.

Calipari ES, Ferris MJ, Siciliano CA, Jones SR. Differential influence of dopamine transport rate on the potencies of cocaine, amphetamine, and methylphenidate. ACS Chem Neurosci. 2015;6(1):155-162.

Siciliano CA, Calipari ES, Ferris MJ, Jones SR. Adaptations of presynaptic dopamine terminals induced by psychostimulant self-administration. ACS Chem Neurosci. 2015;6(1):27-36.

Ferris MJ, Calipari ES, Rose JH, Siciliano CA, Sun H, Chen R, Jones SR. A single amphetamine infusion reverses deficits in dopamine nerve-terminal function caused by a history of cocaine self-administration. Neuropsychopharmacology. 2015;40(8):1826-1836.

Melchior JR, Ferris MJ, Stuber GD, Riddle DR, Jones SR. Optogenetic versus electrical stimulation of dopamine terminals in the nucleus accumbens reveals local modulation of presynaptic release. J Neurochem. 2015;134(5):833-844.

Siciliano CA, Ferris MJ, Jones SR. Cocaine self-administration disrupts mesolimbic dopamine circuit function and attenuates dopaminergic responsiveness to cocaine. Eur J Neurosci. 2015;42(4):2091-2096.

Yorgason JT, Calipari ES, Ferris MJ, Karkhanis AN, Fordahl SC, Weiner JL, Jones SR. Social isolation rearing increases dopamine uptake and psychostimulant potency in the striatum. Neuropharmacology. 2015;101():471-479.

Siciliano C, Gabriele A, Jones S, Ferris M. Dissociating appetitive and consummatory behavior in drug use prone and resistant animals [abstract]. Neuropsychopharmacology. 2015;40(Suppl 1):S251-S252.

Calipari ES, Ferris MJ, Melchior JR, Bermejo K, Salahpour A, Roberts DC, Jones SR. Methylphenidate and cocaine self-administration produce distinct dopamine terminal alterations. Addict Biol. 2014;19(2):145-155.

Yorgason JT, Ferris MJ, Steffensen SC, Jones SR. Frequency-dependent effects of ethanol on dopamine release in the nucleus accumbens. Alcohol Clin Exp Res. 2014;38(2):438-447.

Calipari ES, Ferris MJ, Jones SR. Extended access of cocaine self-administration results in tolerance to the dopamine-elevating and locomotor-stimulating effects of cocaine. J Neurochem. 2014;128(2):224-232.

Calipari ES, Ferris MJ, Siciliano CA, Zimmer BA, Jones SR. Intermittent cocaine self-administration produces sensitization of stimulant effects at the dopamine transporter. J Pharmacol Exp Ther. 2014;349(2):192-198.

Siciliano CA, Calipari ES, Ferris MJ, Jones SR. Biphasic mechanisms of amphetamine action at the dopamine terminal. J Neurosci. 2014;34(16):5575-5582.

Daigle TL, Ferris MJ, Gainetdinov RR, Sotnikova TD, Urs NM, Jones SR, Caron MG. Selective deletion of GRK2 alters psychostimulant-induced behaviors and dopamine neurotransmission. Neuropsychopharmacology. 2014;39(10):2450-2462.

Ferris MJ, Espana RA, Locke JL, Konstantopoulos JK, Rose JH, Chen R, Jones SR. Dopamine transporters govern diurnal variation in extracellular dopamine tone. Proc Natl Acad Sci U S A. 2014;111(26):E2751-2759.

Ferris MJ, Milenkovic M, Liu S, Mielnik CA, Beerepoot P, John CE, Espana RA, Sotnikova TD, Gainetdinov RR, Borgland SL, Jones SR, Ramsey AJ. Sustained N-methyl-D-aspartate receptor hypofunction remodels the dopamine system and impairs phasic signaling. Eur J Neurosci. 2014;40(1):2255-2263.

Ferris M, Jones S. Individual differences in the modulation of dopamine signals in the ventral striatum by nicotinic acetylcholine receptors [abstract]. Neuropsychopharmacology. 2014;39(Suppl 1):S611.

Siciliano C, Calipari E, Ferris M, Chen R, Jones S. Biphasic mechanisms of amphetamine action at the dopamine terminal [abstract]. FASEB J. 2014;28(1 Suppl):661.4.

Calipari ES, Ferris MJ. Amphetamine mechanisms and actions at the dopamine terminal revisited [journal club article]. J Neurosci. 2013;33(21):8923-8925.

Ferris MJ, Calipari ES, Yorgason JT, Jones SR. Examining the complex regulation and drug-induced plasticity of dopamine release and uptake using voltammetry in brain slices. ACS Chem Neurosci. 2013;4(5):693-703.

Ferris MJ, Calipari ES, Melchior JR, Roberts DC, Espana RA, Jones SR. Paradoxical tolerance to cocaine after initial supersensitivity in drug-use-prone animals. Eur J Neurosci. 2013;38(4):2628-2636.

Calipari ES, Ferris MJ, Zimmer BA, Roberts DC, Jones SR. Temporal pattern of cocaine intake determines tolerance vs sensitization of cocaine effects at the dopamine transporter. Neuropsychopharmacology. 2013;38(12):2385-2392.

Calipari ES, Ferris MJ, Salahpour A, Caron MG, Jones SR. Methylphenidate amplifies the potency and reinforcing effects of amphetamines by increasing dopamine transporter expression. Nat Commun. 2013;4():2720.

Ferris MJ, Calipari ES, Mateo Y, Melchior JR, Roberts DCS, Jones SR. Cocaine self-administration produces pharmacodynamic tolerance: differential effects on the potency of dopamine transporter blockers, releasers, and methylphenidate. Neuropsychopharmacology. 2012;37(7):1708-1716.

Oleson EB, Ferris MJ, Espana RA, Harp J, Jones SR. Effects of the histamine H1 receptor antagonist and benztropine analog diphenylpyraline on dopamine uptake, locomotion and reward. Eur J Pharmacol. 2012;683(1-3):161-165.

Ferris MJ, Mateo Y, Roberts DCS, Jones SR. Cocaine-insensitive dopamine transporters with intact substrate transport produced by self-administration. Biol Psychiatry. 2011;69(3):201-207.

Ferris MJ, Frederick-Duus D, Fadel J, Mactutus CF, Booze RM. Hyperdopaminergic tone in HIV-1 protein treated rats and cocaine sensitization. J Neurochem. 2010;115(4):885-896.

Ferris MJ, Frederick-Duus D, Fadel J, Mactutus CF, Booze RM. In vivo microdialysis in awake, freely moving rats demonstrates HIV-1 Tat-induced alterations in dopamine transmission. Synapse. 2009;63(3):181-185.

Ferris MJ, Frederick-Duus D, Fadel J, Mactutus CF, Booze RM. The human immunodeficiency virus-1-associated protein, Tat1-86, impairs dopamine transporters and interacts with cocaine to reduce nerve terminal function: a no-net-flux microdialysis study. Neuroscience. 2009;159(4):1292-1299.

Ferris MJ, Mactutus CF, Booze RM. Neurotoxic profiles of HIV, psychostimulant drugs of abuse, and their concerted effect on the brain: current status of dopamine system vulnerability in neuroAIDS. Neurosci Biobehav Rev. 2008;32(5):883-909.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Physiology & Pharmacology

Mark John Ferris, Ph.D.

Mark John Ferris, Ph.D.

Assistant Professor, Physiology & Pharmacology

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