Profile

Jorge P. Figueroa, M.D.Wake Forest School of Medicine

Jorge P. Figueroa, M.D.

Professor,

Contact Information

Academic: 336-716-2351 | Department: 336-716-4039

Email: figueroa@wakehealth.edu

Education & Training

  • M.D., Univ of Chile School of Medicine Santiago-Chile , 1979
  • Ph.D., Cornell University , 1987
  • Fellowship, Univ of Chile School of Medici, 1982
Jorge P. Figueroa, M.D.

Jorge P. Figueroa, M.D.

Professor, Maternal-Fetal Medicine
Obstetrics & Gynecology

Research Interests

hypertension, obesity

Contact Information

Academic: 336-716-2351 | Department: 336-716-4039

Email: figueroa@wakehealth.edu

Recent Publications

Lee JH, Zhang J, Massmann GA, Figueroa JP. Antenatal betamethasone increases vascular reactivity to endothelin-1 by upregulation of CD38/cADPR signaling. J Dev Orig Health Dis. 2014;5(1):56-62.

Figueroa JP, Zhang J, Massmann AG. Role of transient receptor potential channels (TRPC) on vascular reactivity responses to endothelin in sheep exposed antenatally to betamethasone [abstract]. Reprod Sci. 2014;21(3 Suppl):164A.

Lee JH, Zhang J, Massman GA, Figueroa JP. Antenatal steroid exposure alters transient receptor potential cation channels (TRPC) function in adult sheep arteries [abstract]. Reprod Sci. 2014;21(3 Suppl):163A-164A.

Su YX, Jorge FP, Rose JC. Sex differences in the effects of prenatal betamethesone (Beta) exposure on sodium uptake in ovine renal proximal tubule cells (RPTC) from young adult sheep [abstract]. Reprod Sci. 2014;21(3 Suppl):367A.

Zhang J, Massmann AG, Figueroa JP. Antenatal exposure to betamethasone has permanent effects on omental fat preadipocytes and on in vitro adipogenesis in adult sheep [abstract]. Reprod Sci. 2014;21(3 Suppl):165A.

Lee JH, Zhang J, Flores L, Rose JC, Massmann GA, Figueroa JP. Antenatal betamethasone has a sex-dependent effect on the in vivo response to endothelin in adult sheep. Am J Physiol Regul Integr Comp Physiol. 2013;304(8):R581-R587.

Chen K, Bi J, Su Y, Figueroa J, Chappell M, Rose J. Gender affects responses of renal ACE and ACE2 activity to unilateral nephrectomy [abstract]. Reprod Sci. 2013;20(3 Suppl 1A):335A.

Chen K, Bi J, Figueroa J, Chappell M, Rose J. Gender differences in effects of prenatal betamethasone exposure on sheep renal ACE and ACE2 activity: a possible mechanism in fetal programmed hypertension in males [abstract]. Reprod Sci. 2013;20(3 Suppl 1A):275A.

Zhang J, Lee J-H, Massmann AG, Figueroa JP. Antenatal betamethasone increases transient receptor potential cation channels (TRPC) expression in sheep arteries [abstract]. Reprod Sci. 2013;20(3 Suppl):83A-84A.

Su Y, Bi J, Figueroa JP, Rose JC. Gender differences in the effect of antenatal betamethasone (Beta) exposure on NHE3 and Na/K-ATPase expression in adult sheep kidney [abstract]. Reprod Sci. 2013;20(3 Suppl):141A-142A.

Lee J-H, Zhang J, Massmann AG, Flores L, Figueroa JP. Antenatal betamethsone (Beta) effects on ryanodine (RyR) mediated vascular reactivity in adult sheep [abstract]. Reprod Sci. 2013;20(3 Suppl):202A-203A.

Lee J-H, Zhang J, Massmann AG, Figueroa JP. Antenatal glucocorticoids increase in vitro vascular reactivity in the adult offspring via the ADPR cyclase pathway [abstract]. Reprod Sci. 2013;20(3 Suppl):203A.

Massmann AG, Flores L, Lee J-H, Zhang J, Figueroa JP. Effects of antenatal glucocorticoids and diet-induced obesity on plasma and adipose tissue adiponectin [abstract]. Reprod Sci. 2013;20(3 Suppl):203A.

Flores L, Massmann AG, Figueroa JP. Effects of pre-pregnancy maternal obesityon adiponectin plasma concentration and adipose tissue expression [abstract]. Reprod Sci. 2013;20(3 Suppl):245A.

Akoma UN, Guillermo VJ, Searing KL, Massmann AG, Figueroa JP. Effects of severe obesity on the levels of inflammatory markers in maternal and fetal compartments at term [abstract]. Reprod Sci. 2013;20(3 Suppl):305A.

Bi JL, Contag S, Su YX, Chen K, Figueroa J, Chappell M, Rose JC. Sex differences in oxidative stress following uniphrectomy in antenatal glucocorticoid exposed sheep [abstract]. FASEB J. 2013;27():733.2.

Su Y, Tang L, Bi J, Figueroa JP, Rose JC. Gender differences in the effect of antenatal betamethasone (Beta) exposure on sodium uptake in ovine renal proximal tubule cells (RPTC) [abstract]. Reprod Sci. 2012;19(3 Suppl):345A.

Su Y, Bi J, Tang L, Figueroa JP, Rose JC. Effects of prenatal betamethasone (Beta) exposure and unilateral nephrectomy on sodium uptake in ovine renal proximal tubule cells from young adult male sheep [abstract]. FASEB J. 2012;26(Meeting Abstracts):1102.3.

Bi J, Su Y, Figueroa J, Chappell MC, Rose JC. Impact of antenatal betamethasone (B) on p47 phox in kidney and 8-isoprostane responses to angiotensin II in proximal tubule cells in male sheep after uninephrectomy [abstract]. FASEB J. 2012;26(Meeting Abstracts):1101.10.

Massmann AG, Lee J-H, Flores L, Zhang J, Figueroa JP. Effects of antenatal glucocorticoids and diet-induced obesity on skeletal muscle insulin signaling pathways [abstract]. Reprod Sci. 2012;19(3 Suppl):264A.

Zhang J, Massmann AG, Figueroa JP. Effects of antenatal glucocorticoids and diet-induced obesity on adipose tissue renin angiotensin system (RAS) in adult sheep [abstract]. Reprod Sci. 2012;19(3 Suppl):347A.

Figueroa JP, Zhang J, Massman AG [sic] [Massmann AG]. Antenatal betamethasone effects on visceral fat function are associated with cardiometabolic programming in adult sheep [abstract]. Reprod Sci. 2012;19(3 Suppl):158A.

Tang L, Bi J, Chappell M, Figueroa J, Rose JC. The effect of antenatal steroid exposure on sodium uptake in ovine renal proximal tubule cells (RPTC) [abstract]. FASEB J. 2011;25(Meeting Abstracts):1029.12.

Bi J, Tang L, Figueroa J, Chappell MC, Rose JC. Antenatal betamethasone (B) and gender affect 8-isoprostane responses to unilateral nephrectomy [abstract]. FASEB J. 2011;25(Meeting Abstracts):1029.11.

Bi J, Figueroa JP, Chappell MC, Rose JC. Effect of prenatal betamethasone exposure on renal functional reserve in the young adult female sheep [abstract]. Reprod Sci. 2011;18(4 Suppl):90A.

Figueroa JP, Zhang J, Rose JC, Massmann AG. Antenatal glucocorticoid exposure alters in vivo endothelin responsiveness and signaling in adult sheep [abstract]. Reprod Sci. 2011;18(4 Suppl):209A.

Massmann AG, Zhang J, Figueroa JP. Pre-pregnancy maternal obesity increases blood pressure and vascular reactivity response to angiotensin II [abstract]. Reprod Sci. 2011;18(4 Suppl):215A.

Su Y, Shaltout HA, Figueroa JP, Chappell M, Rose JC. Effect of early glucocorticoid treatment on GR and MR expression in adult sheep kidney [abstract]. Reprod Sci. 2011;18(4 Suppl):220A.

Zhang J, Massmann AG, Chappell MC, Figueroa JP. Antenatal glucocorticoids and diet-induced obesity alter adipose tissue function [abstract]. Reprod Sci. 2011;18(4 Suppl):223A.

Figueroa JP, Zhang J, Massmann AG. Gender-specific cardiovascular effects of prepregnancy maternal obesity in sheep [abstract]. J Dev Orig Health Dis. 2011;2(Suppl 1):S91.

Su Y, Bi J, Figueroa JP, Rose JC. Gender-specific effects of prenatal betamethesone (Beta) exposure and unilateral nephrectomy on the intrarenal renin-angiotension system (RAS) in adult sheep [abstract]. Endocr Rev. 2011;32(3 Meeting Abstracts):.


Connors N, Valego NK, Carey LC, Figueroa JP, Rose JC. Fetal and postnatal renin secretion in female sheep exposed to prenatal betamethasone. Reprod Sci. 2010;17(3):239-246.

Massmann AG, Zhang J, Pulgar VM, Figueroa JP. A sheep model of maternal obesity: effects on plasma levels of inflammatory mediators in the offspring [abstract]. Reprod Sci. 2010;17(3 Suppl):192A.

Massmann AG, Zhang J, Figueroa JP. Antenatal glucocorticoids and diet-induced obesity alter adipose tissue renin angiotensinin system (RAS) components in the adult offspring [abstract]. Reprod Sci. 2010;17(3 Suppl):222A.

Zhang J, Massmann A, Pulgar VM, Figueroa JP. Pre-pregnancy maternal obesity: a sheep model to study the impact of obesity on maternal adaptations [abstract]. Reprod Sci. 2010;17(3 Suppl):211A.

Eckman DM, Kerr BA, Fuloria M, Simandle SA, Watt SE, Rose JC, Figueroa JP. Antenatal betamethasone alters vascular reactivity in adult female ovine cerebral arteries. Pediatr Res. 2010;68(4):344-348.

Shaltout HA, Rose JC, Figueroa JP, Chappell MC, Diz DI, Averill DB. Acute AT1-receptor blockade reverses the hemodynamic and baroreflex impairment in adult sheep exposed to antenatal betamethasone. Am J Physiol Heart Circ Physiol. 2010;299(2):H541-H547.

Tang L, Bi J, Valego N, Carey L, Figueroa J, Chappell M, Rose JC. Prenatal betamethasone exposure alters renal function in immature sheep: sex differences in effects. Am J Physiol Regul Integr Comp Physiol. 2010;299(3):R793-R803.

Su YX, Figueroa JP, Rose JC. Antenatal betamethasone (Beta) exposure enhances leptin induced inhibition of steroidogenic acute regulatory protein (StAR) and ACTH-receptor expression in adult ovine adrenocortical cells [abstract]. Endocr Rev. 2010;31(3 Suppl 1):S692.

Shaltout HA, Figueroa JP, Rose JC, Diz DI, Chappell MC. Alterations in circulatory and renal angiotensin-converting enzyme and angiotensin-converting enzyme 2 in fetal programmed hypertension. Hypertension. 2009;53(2):404-408.

Tang L, Carey LC, Bi J, Valego N, Sun X, Deibel P, Perrott J, Figueroa JP, Chappell MC, Rose JC. Gender differences in the effects of antenatal betamethasone exposure on renal function in adult sheep. Am J Physiol Regul Integr Comp Physiol. 2009;296(2):R309-317.

Massmann AG, Zhang J, Figueroa JP. Effects of antenatal glucocorticoids and diet-induced obesity on insulin sensitivity and signaling in adult sheep [abstract]. Reprod Sci. 2009;16(3 Suppl):329A.

Russell J, Massmann AG, Zhang J, Pulgar VM, Figueroa JP. Role of endothelin in the cardiovascular abnormalities associated with antenatal glucocorticoids in sheep [abstract]. Reprod Sci. 2009;16(3 Suppl):Abstr 888.

Su YX, Figueroa JP, Rose JC. Effect of leptin on cortisol production in ovine adrenocortical cells [abstract]. Reprod Sci. 2009;16(3 Suppl):121A.

Zhang J, Massmann AG, Figueroa JP. Effects of antenatal glucocorticoids and diet-induced obesity on adipose tissue in adult sheep [abstract]. Reprod Sci. 2009;16(3 Suppl):145A.

Gwathmey TM, Shaltout HA, Pendergrass KD, Pirro NT, Figueroa JP, Rose JC, Diz DI, Chappell MC. Nuclear angiotensin II type 2 (AT2) receptors are functionally linked to nitric oxide production. Am J Physiol Renal Physiol. 2009;296(6):F1484-1493.

Pulgar VM, Hong JK, Jessup JA, Massmann AG, Diz DI, Figueroa JP. Mild chronic hypoxemia modifies expression of brain stem angiotensin peptide receptors and reflex responses in fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2009;297(2):R446-R452.

Shaltout HA, Diz DI, Figueroa JP, Chappell MC, Rose JC. Sympathetic nervous system mediated responses to behavioral or pharmacologic challenges are exaggerated as a result of antenatal betamethasone exposure [abstract]. Hypertension. 2009;54(4):e101`.

Shaltout HA, Figueroa JP, Rose JC, Chappell MC, Averill DB, Diz DI. Antenatal betamethasone causes alterations in angiotensin receptors in sheep brain in a gender specific manner [abstract]. FASEB J. 2009;23(1 Meeting Abstracts):941.11.

Bi JL, Contag S, Figueroa JP, Tang LJ, Chappell MC, Rose JC. Effect of intrarenal infusion of angiotensin-(1-7) (Ang 1-7) in male sheep with or without prenatal exposure to betamethasone (B) [abstract]. Reprod Sci. 2008;15(2 Suppl):272A.

Carey LC, Figueroa JP, Rose JC. Effect of prenatal betamethasone exposure on responsiveness of pituitary cells isolated from adult sheep [abstract]. Reprod Sci. 2008;15(2 Suppl):272A-273A.

Contag SA, Bi J, Figueroa JP, Tang L, Chappell M, Rose JC. Effect of intrarenal infusion of angiotensin II (Ang II) in male sheep with or without prenatal exposure to antenatal betamethasone (B) [abstract]. Reprod Sci. 2008;15(2 Suppl):275A.

Figueroa JP, Massmann AG, Zhang J, Rose JC. Nephron number and hypertension following antenatal glueocorticoids: is there a causal relationship? [abstract]. Reprod Sci. 2008;15(2 Suppl):271A.

Kantorowicz L, Valego NK, Figueroa JP, Chappell MC, Tang L, Rose JC. Plasma renin concentration in female sheep following antenatal betamethasone exposure [abstract]. Reprod Sci. 2008;15(2 Suppl):275A.

Massmann AG, Zhang J, Figueroa JP. Antenatal betamethasone exposure at 80 days gestation alters kidney medulla endothelin B receptor (ETB) expression in adult sheep offspring [abstract]. Reprod Sci. 2008;15(2 Suppl):273A.

Pulgar V, Diz D, Hong JK, Figueroa JP. Chronic mild hypoxemia during late gestation decreases baroreceptor gain in fetal sheep [abstract]. Reprod Sci. 2008;15(2 Suppl):129A.

Pulgar VM, Massmann AG, Figueroa JP. Antenatal exposure to betamethasone enhances the vascular response to angiotensin II in adult sheep offspring [abstract]. Reprod Sci. 2008;15(2 Suppl):272A.

Smith JG, Nakahara S, Westwood B, Figueora [sic] J [Figueroa J], Chappell MC, Rose JC. Prenatal betamethasone exposure alters renin angiotensin system enzyme expression in adult male sheep [abstract]. Reprod Sci. 2008;15(2 Suppl):274A.

Smith JG, Westwood B, Nakara S, Fiqueroa [sic] J, [Figueroa J], Chappell MC, Rose JC. Gender differences in key enzymes of the renin angiotensin system in adult sheep [abstract]. Reprod Sci. 2008;15(2 Suppl):276A.

Tang LJ, Carrey L, Valego N, Deibel P, Perrott J, Figueroa J, Chappell M, Rose JC. The effect of betamethasone exposure in mid-gestation on renal sodium excretion in male sheep [abstract]. Reprod Sci. 2008;15(2 Suppl):233A.

Zhang J, Pulgar VM, Massmann AG, Figueroa JP. Effects of diet-induced obesity on arterial blood pressure in adult sheep exposed antenataly to glucocorticoids [abstract]. Reprod Sci. 2008;15(2 Suppl):75A.

Zhang J, Massmann AG, Pulgar VM, Figueroa JP. Effects of diet-induced obesity on insulin sensitivity in adult sheep exposed antenataly to glucocorticoids [abstract]. Reprod Sci. 2008;15(2 Suppl):276A.

Brosnihan KB, Li P, Figueroa JP, Ganten D, Ferrario CM. Estrogen, nitric oxide, and hypertension differentially modulate agonist-induced contractile responses in female transgenic (mRen2)27 hypertensive rats. Am J Physiol Heart Circ Physiol. 2008;294(5):H1995-2001.

Shaltout HA, Figueroa JP, Rose JC, Diz DI, Chappell MC. Reduced renal ACE2 in fetal programmed hypertension [abstract]. Hypertension. 2008;52(4):e52.

Shaltout HA, Figueroa JP, Rose JC, Chappell MC, Averill DB, Diz DI. Evidence of Ang-(1-7) deficiency in antenatal betamethasone-treated young adult sheep [abstract]. Hypertension. 2008;52(4):e107.

Kantorowicz L, Valego NK, Tang L, Figueroa JP, Chappell MC, Carey LC, Rose JC. Plasma and renal renin concentrations in adult sheep after prenatal betamethasone exposure. Reprod Sci. 2008;15(8):831-838.

Shaltout HA, Westwood BM, Averill DB, Ferrario CM, Figueroa JP, Diz DI, Rose JC, Chappell MC. Angiotensin metabolism in renal proximal tubules, urine and serum of sheep: evidence for ACE2-dependent processing of angiotensin II. Am J Physiol Renal Physiol. 2007;292(1):F82-F91.

Shaltout HA, Figueroa JP, Rose JC, Chappell MC, Averill DB, Diz DI. Gender differences in the development of insulin resistance in adult sheep as result of antenatal betamethasone [abstract]. FASEB J. 2007;21(5 Pt I):A434.

Tang L, Chen K, Carey L, Valego N, Figueroa J, Deibel P, Perrott J, Rose JC. The effect of betamethasone exposure in mid-gestation on renal function in adult sheep [abstract]. FASEB J. 2007;21(5):A502.

Pulgar VM, Zhang J, Massmann GA, Figueroa JP. Mild chronic hypoxia modifies the fetal sheep neural and cardiovascular responses to repeated umbilical cord occlusion. Brain Res. 2007;1176():18-26.

Gwathmey TM, Diz DI, Pirro NT, Figueroa J, Rose JC, Chappell MC. Nuclear angiotensin II-type 2 receptors are differentially expressed in the sheep kidney [abstract]. Hypertension. 2007;50(4):e97.

Figueroa JP. Prenatal glucocorticoids and the programming of renal sodium handling mechanisms in the adult [abstract]. Early Hum Dev. 2007;83(Suppl 1):S45.

Cavaco-Goncalves S, Marques CC, Horta AEM, Figueroa JP. Increased cervical electrical activity during oestrus in progestagen treated ewes: possible role in sperm transport. Anim Reprod Sci. 2006;93(3-4):360-365.

Pulgar VM, Zhang J, Massmann GA, Figueroa JP. Prolonged mild hypoxia alters fetal sheep electrocorticogram activity. J Soc Gynecol Investig. 2006;13(6):404-411.


Chappell MC, Figueroa J, Rose JC, Westwood BM. Gender difference in serum ACE2-dependent metabolism of angiotensin II [abstract]. J Hypertens. 2006;24(Suppl 6):125.

Shaltout HA, Figueroa JP, Rose JC, Chappell M, Diz DI, Averill DB. Antenatal betamethasone causes angiotensin II-mediated impairment of cardiovascular function [abstract]. Hypertension. 2006;48(4):e32.

Shaltout HA, Figueroa JP, Rose JC, Chappell MC, Diz DI, Averill DB. Antenatal betamethasone causes angiotensin II-mediated impairment of baroreflex control of heart rate [abstract]. J Hypertens. 2006;24(Suppl 6):159.

Shaltout HA, Figueroa JP, Rose JC, Averill DB, Diz DI, Chappell MC. Increased blood pressure is associated with lower serum ACE2 activity and higher ACE activity following antenatal steroid exposure [abstract]. J Hypertens. 2006;24(Suppl 6):127.

Westwood BM, Figueroa J, Rose JC, Chappell MC. Gender differences in ACE2-dependent metabolism of angiotensin II in the serum of sheep [abstract]. Hypertension. 2006;48(4):e46.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Jorge P. Figueroa, M.D.

Jorge P. Figueroa, M.D.

Professor, Maternal-Fetal Medicine
Obstetrics & Gynecology

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