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Barry I. Freedman, M.D.Wake Forest School of Medicine

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Barry I. Freedman, M.D.

Section Chief,
Professor,



Clinical Interests

Atherosclerosis, Nephrology, Genetic Factors in Kidney Disease and Diabetes, Kidney Disease, Diabetes, Clinical Nephrology, Hypertension

Contact Information

Returning Patient Appointments: 336-716-4650
Department: 336-716-4650

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Education & Training

  • B.S., CUNY Brooklyn College, 1980
  • M.D., SUNY Brooklyn College of Medicine, 1984
  • Residency, Internal Medicine, Eastern Virginia Med School, 1987
  • Fellowship, WFU School of Medicine, 1989

Board Certifications

  • American Board of Internal Medicine, Internal Medicine
  • American Board of Internal Medicine, Nephrology

Memberships

  • Int'L Society Of Nephrology
  • Nat'L Kidney Foundation
  • North Carolina Medical Assn
  • Renal Physicians Assn
  • Am Coll Of Physicians
  • Am Heart Association
  • Am Soc Of Hypertension
  • Am Soc Of Nephrology
  • Alpha Omega Alpha

NPI Number

  • 1245215672
Barry I. Freedman, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

Barry I. Freedman, M.D.

Section Chief, Nephrology
Professor, Nephrology
Center on Diabetes, Obesity, and Metabolism
Institute for Regenerative Medicine
Urology

Research Interests

Kidney Failure, Chronic; African Americans; Diabetes Mellitus, Type 2; Apolipoproteins; Diabetic Nephropathies
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Contact Information

Academic: 336-716-4650 | Department: 336-716-4650

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Recent Publications

Blood pressure indices and cardiovascular disease mortality in persons with or without diabetes mellitus. Gomadam P, Shah A, Qureshi W, Yeboah PN [sic] Yeboah PK, Freedman BI, Bowden D, Soliman EZ, Yeboah J.. J Hypertens. 2018;36(1):85-92.

FGF23 concentration and APOL1 genotype are novel predictors of mortality in African Americans with type 2 diabetes. Chan GC, Divers J, Russell GB, Langefeld CD, Wagenknecht LE, Hsu FC, Xu J, Smith SC, Palmer ND, Hicks PJ, Bowden DW, Register TC, Ma L, Carr JJ, Freedman BI.. Diabetes Care. 2018;41(1):178-186.

Genome-wide association of CKD progression: the chronic renal insufficiency cohort study. Parsa A, Kanetsky PA, Xiao R, Gupta J, Mitra N, Limou S, Xie D, Xu H, Anderson AH, Ojo A, Kusek JW, Lora CM, Hamm LL, He J, Sandholm N, Jeff J, Raj DE, Boger CA, Bottinger E, Salimi S, Parekh RS, Adler SG, Langefeld CD, Bowden DW, Groop PH,.. J Am Soc Nephrol. 2017;28(3):923-934.

Effect of replacing race with apolipoprotein L1 genotype in calculation of kidney donor risk index. Julian BA, Gaston RS, Brown WM, Reeves-Daniel AM, Israni AK, Schladt DP, Pastan SO, Mohan S, Freedman BI, Divers J.. Am J Transplant. 2017;17(6):1540-1548.

APOL1 renal-risk variants induce mitochondrial dysfunction. Ma L, Chou JW, Snipes JA, Bharadwaj MS, Craddock AL, Cheng D, Weckerle A, Petrovic S, Hicks PJ, Hemal AK, Hawkins GA, Miller LD, Molina AJ, Langefeld CD, Murea M, Parks JS, Freedman BI.. J Am Soc Nephrol. 2017;28(4):1093-1105.

APOL1 genotype, blood pressure, and survival in African Americans with nondiabetic nephropathy [commentary]. Robinson TW, Freedman BI.. Kidney Int. 2017;91(2):276-278.

APOL1 gene kidney risk variants and cardiovascular disease: getting to the heart of the matter. McLean NO, Robinson TW, Freedman BI.. Am J Kidney Dis. 2017;70(2):281-289.

A low-frequency inactivating Akt2 variant enriched in the Finnish population is associated with fasting insulin levels and type 2 diabetes risk. Manning A, Highland HM, Gasser J, Sim X, Tukiainen T, Fontanillas P, Grarup N, Rivas MA, Mahajan A, Locke AE, Cingolani P, Pers TH, Vinuela A, Brown AA, Wu Y, Flannick J, Fuchsberger C, Gamazon ER, Gaulton KJ, Im HK, Teslovich TM, Blackwell TW,.. Diabetes. 2017;66(7):2019-2032.

Efficacy and safety of low-dose heparin in hemodialysis. Murea M, Russell GB, Daeihagh P, Saran AM, Pandya K, Cabrera M, Burkart JM, Freedman BI.. Hemodial Int. 2017;():.

A null variant in the apolipoprotein L3 gene is associated with non-diabetic nephropathy. Skorecki KL, Lee JH, Langefeld CD, Rosset S, Tzur S, Wasser WG, Shemer R, Hawkins GA, Divers J, Parekh RS, Li M, Sampson MG, Kretzler M, Pollak MR, Shah S, Blackler D, Nichols B, Wilmot M, Alper SL, Freedman BI, Friedman DJ.. Nephrol Dial Transplant. 2017;():.

Blood pressure indices and cardiovascular mortality in diabetics and non diabetics [abstract]. Gomadam P, Qureshi W, Shah A, Freedman B, Bowden DW, Soliman E, Yeboah J.. J Am Coll Cardiol. 2017;69(11 Suppl):1849.

Fluid and volume therapy in the ICU. Robinson TW, Freedman BI. In: Vincent JL, Abraham E, Moore FA, Kochanek PM, Fink MP, eds. Textbook of critical care. 7th ed. Philadelphia (PA): Elsevier;2017: 761-765.e1.

Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium. Ng MCY, Graff M, Lu Y, Justice AE, Mudgal P, Liu CT, Young K, Yanek LR, Feitosa MF, Wojczynski MK, Rand K, Brody JA, Cade BE, Dimitrov L, Duan Q, Guo X, Lange LA, Nalls MA, Okut H, Tajuddin SM, Tayo BO, Vedantam S, Bradfield JP, Chen G,.. PLoS Genet. 2017;13(4):e1006719.

Associations of early kidney disease with brain magnetic resonance imaging and cognitive function in African Americans with type 2 diabetes mellitus. Freedman BI, Sink KM, Hugenschmidt CE, Hughes TM, Williamson JD, Whitlow CT, Palmer ND, Miller ME, Lovato LC, Xu J, Smith SC, Launer LJ, Barzilay JI, Cohen RM, Sullivan MD, Bryan RN, Wagner BC, Bowden DW, Maldjian JA, Divers J.. Am J Kidney Dis. 2017;70(5):627-637.

Genetic epidemiology in kidney disease. Ainsworth HC, Langefeld CD, Freedman BI.. Nephrol Dial Transplant. 2017;32(Suppl 2):159-169.

Hepatocyte ABCA1 deletion impairs liver insulin signaling and lipogenesis. Key CC, Liu M, Kurtz CL, Chung S, Boudyguina E, Dinh TA, Bashore A, Phelan PE, Freedman BI, Osborne TF, Zhu X, Ma L, Sethupathy P, Biddinger SB, Parks JS.. Cell Rep. 2017;19(10):2116-2129.

A tripartite complex of suPAR, APOL1 risk variants and alphavbeta3 integrin on podocytes mediates chronic kidney disease. Hayek SS, Koh KH, Grams ME, Wei C, Ko YA, Li J, Samelko B, Lee H, Dande RR, Lee HW, Hahm E, Peev V, Tracy M, Tardi NJ, Gupta V, Altintas MM, Garborcauskas G, Stojanovic N, Winkler CA, Lipkowitz MS, Tin A, Inker LA, Levey AS, Zeier M, Freedman BI,.. Nat Med. 2017;23(8):945-953.

Effects of intensive BP control in CKD. Cheung AK, Rahman M, Reboussin DM, Craven TE, Greene T, Kimmel PL, Cushman WC, Hawfield AT, Johnson KC, Lewis CE, Oparil S, Rocco MV, Sink KM, Whelton PK, Wright JT Jr, Basile J, Beddhu S, Bhatt U, Chang TI, Chertow GM, Chonchol M,.. J Am Soc Nephrol. 2017;28(9):2812-2823.

Effects of weight-based ultrafiltration rate limits on intradialytic hypotension in hemodialysis. Pirkle JL Jr, Comeau ME, Langefeld CD, Russell GB, Balderston SS, Freedman BI, Burkart JM.. Hemodial Int. 2017;():.

Adiponectin isoform patterns in ethnic-specific ADIPOQ mutation carriers: the IRAS Family Study. Tabb KL, Gao C, Hicks PJ, Hawkins GA, Rotter JI, Chen YI, Guo X, Norris JM, Lorenzo C, Freedman BI, Bowden DW, Palmer ND.. Obesity (Silver Spring). 2017;25(8):1384-1390.

Type 2 diabetes variants disrupt function of SLC16A11 through two distinct mechanisms. Rusu V, Hoch E, Mercader JM, Tenen DE, Gymrek M, Hartigan CR, DeRan M, von Grotthuss M, Fontanillas P, Spooner A, Guzman G, Deik AA, Pierce KA, Dennis C, Clish CB, Carr SA, Wagner BK, Schenone M, Ng MCY, Chen BH, Centeno-Cruz F, Zerrweck C,.. Cell. 2017;170(1):.

APOL1 renal-risk variants do not associate with incident cardiovascular disease or mortality in the Systolic Blood Pressure Intervention Trial. Freedman BI, Rocco MV, Bates JT, Chonchol M, Hawfield AT, Lash JP, Papademetriou V, Sedor JR, Servilla K, Kimmel PL, Wall BM, Pajewski NM.. Kidney Int Rep. 2017;2(4):713-720.

Transancestral mapping and genetic load in systemic lupus erythematosus. Langefeld CD, Ainsworth HC, Cunninghame Graham DS, Kelly JA, Comeau ME, Marion MC, Howard TD, Ramos PS, Croker JA, Morris DL, Sandling JK, Almlof JC, Acevedo-Vasquez EM, Alarcon GS, Babini AM, Baca V, Bengtsson AA, Berbotto GA,.. Nat Commun. 2017;8():16021.

Effects of intensive systolic blood pressure control on kidney and cardiovascular outcomes in persons without kidney disease: a secondary analysis of a randomized trial. Beddhu S, Rocco MV, Toto R, Craven TE, Greene T, Bhatt U, Cheung AK, Cohen D, Freedman BI, Hawfield AT, Killeen AA, Kimmel PL, Lash J, Papademetriou V, Rahman M, Rastogi A, Servilla K, Townsend RR, Wall B, Whelton PK.. Ann Intern Med. 2017;167(6):375-383.

Genetic regulation of adipose tissue transcript expression is involved in modulating serum triglyceride and HDL-cholesterol. Sajuthi SP, Sharma NK, Comeau ME, Chou JW, Bowden DW, Freedman BI, Langefeld CD, Parks JS, Das SK.. Gene. 2017;632():50-58.

Effect of intensive blood-pressure treatment on patient-reported outcomes. Berlowitz DR, Foy CG, Kazis LE, Bolin LP, Conroy MB, Fitzpatrick P, Gure TR, Kimmel PL, Kirchner K, Morisky DE, Newman J, Olney C, Oparil S, Pajewski NM, Powell J, Ramsey T, Simmons DL, Snyder J, Supiano MA, Weiner DE, Whittle J, Rocco M,.. N Engl J Med. 2017;377(8):733-744.

Vascular access placement order and outcomes in hemodialysis patients: a longitudinal study. Murea M, Brown WM, Divers J, Moossavi S, Robinson TW, Bagwell B, Burkart JM, Freedman BI.. Am J Nephrol. 2017;46(4):268-275.

Clinical outcomes by race and ethnicity in the Systolic Blood Pressure Intervention Trial (SPRINT): a randomized clinical trial. Still CH, Rodriguez CJ, Wright JT Jr, Craven TE, Bress AP, Chertow GM, Whelton PK, Whittle JC, Freedman BI, Johnson KC, Foy CG, He J, Kostis JB, Lash JP, Pedley CF, Pisoni R, Powell JR, Wall BM.. Am J Hypertens. 2017;31(1):97-107.

Influence of baseline diastolic blood pressure on effects of intensive compared to standard blood pressure control. Beddhu S, Chertow GM, Cheung AK, Cushman WC, Rahman M, Greene T, Wei G, Campbell RC, Conroy M, Freedman BI, Haley WE, Horwitz EJ, Kitzman DW, Lash J, Papademetriou V, Pisoni R, Riessen E, Rosendorff C, Watnick SG, Whittle J, Whelton PK.. Circulation. 2017;():.

Need to reclassify etiologies of ESRD on the CMS 2728 Medical Evidence Report.. Tucker BM, Freedman BI.. Clin J Am Soc Nephrol. 2017;():.

Diabetic microvascular disease: an endocrine society scientific statement. Barrett EJ, Liu Z, Khamaisi M, King GL, Klein R, Klein BEK, Hughes TM, Craft S, Freedman BI, Bowden DW, Vinik AI, Casellini CM.. J Clin Endocrinol Metab. 2017;102(12):4343-4410.

Apolipoprotein L1 gene effects on kidney transplantation. Freedman BI, Locke JE, Reeves-Daniel AM, Julian BA.. Semin Nephrol. 2017;37(6):530-537.

Effects of intensive blood pressure treatment on acute kidney injury events in the Systolic Blood Pressure Intervention Trial (SPRINT). Rocco MV, Sink KM, Lovato LC, Wolfgram DF, Wiegmann TB, Wall BM, Umanath K, Rahbari-Oskoui F, Porter AC, Pisoni R, Lewis CE, Lewis JB, Lash JP, Katz LA, Hawfield AT, Haley WE, Freedman BI, Dwyer JP, Drawz PE, Dobre M, Cheung AK,.. Am J Kidney Dis. 2017;():.

Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA. Zhao J, Giles BM, Taylor RL, Yette GA, Lough KM, Ng HL, Abraham LJ, Wu H, Kelly JA, Glenn SB, Adler AJ, Williams AH, Comeau ME, Ziegler JT, Marion M, Alarcon-Riquelme ME, Alarcon GS, Anaya JM, Bae SC, Kim D, Lee HS, Criswell LA, Freedman BI, Gilkeson GS,.. Ann Rheum Dis. 2016;75(1):242-252.

Associations between anxiety and depression symptoms and cognitive testing and neuroimaging in type 2 diabetes. Raffield LM, Brenes GA, Cox AJ, Freedman BI, Hugenschmidt CE, Hsu FC, Xu J, Wagner BC, Williamson JD, Maldjian JA, Bowden DW.. J Diabetes Complications. 2016;30(1):143-149.

Hypertension-attributed nephropathy: what's in a name?. Freedman BI, Cohen AH.. Nat Rev Nephrol. 2016;12(1):27-36.

Characterization of circulating APOL1 protein complexes in African Americans. Weckerle A, Snipes JA, Cheng D, Gebre AK, Reisz JA, Murea M, Shelness GS, Hawkins GA, Furdui CM, Freedman BI, Parks JS, Ma L.. J Lipid Res. 2016;57(1):120-130.

APOL1 genotype and kidney transplantation outcomes from deceased African American donors. Freedman BI, Pastan SO, Israni AK, Schladt D, Julian BA, Gautreaux MD, Hauptfeld V, Bray RA, Gebel HM, Kirk AD, Gaston RS, Rogers J, Farney AC, Orlando G, Stratta RJ, Mohan S, Ma L, Langefeld CD, Bowden DW, Hicks PJ, Palmer ND,.. Transplantation. 2016;100(1):194-202.

Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production. Deng Y, Zhao J, Sakurai D, Sestak AL, Osadchiy V, Langefeld CD, Kaufman KM, Kelly JA, James JA, Petri MA, Bae SC, Alarcon-Riquelme ME, Alarcon GS, Anaya JM, Criswell LA, Freedman BI, Kamen DL, Gilkeson GS, Jacob CO, Merrill JT, Gaffney PM, Sivils KM,.. Ann Rheum Dis. 2016;75(11):2007-2013.

Tissue-specific and genetic regulation of insulin sensitivity-associated transcripts in African Americans. Sharma NK, Sajuthi SP, Chou JW, Calles-Escandon J, Demons J, Rogers S, Ma L, Palmer ND, R McWilliams D, Beal J, Comeau M, Cherry K, Hawkins GA, Menon L, Kouba E, Davis D, Burris M, Byerly SJ, Easter L, Bowden DW, Freedman BI, Langefeld CD, Das SK.. J Clin Endocrinol Metab. 2016;101(4):1455-1468.

Analysis of advanced glycation end products in the DHS Mind Study. Adams JN, Martelle SE, Raffield LM, Freedman BI, Langefeld CD, Hsu FC, Maldjian JA, Williamson JD, Hugenschmidt CE, Carr JJ, Cox AJ, Bowden DW.. J Diabetes Complications. 2016;30(2):262-268.

Analysis of the relationships between type 2 diabetes status, glycemic control, and neuroimaging measures in the Diabetes Heart Study Mind. Raffield LM, Cox AJ, Freedman BI, Hugenschmidt CE, Hsu FC, Wagner BC, Xu J, Maldjian JA, Bowden DW.. Acta Diabetol. 2016;53(3):439-447.

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Pattaro C, Teumer A, Gorski M, Chu AY, Li M, Mijatovic V, Garnaas M, Tin A, Sorice R, Li Y, Taliun D, Olden M, Foster M, Yang Q, Chen MH, Pers TH, Johnson AD, Ko YA, Fuchsberger C, Tayo B, Nalls M, Feitosa MF, Isaacs A, Dehghan A, d'Adamo P, Adeyemo A,.. Nat Commun. 2016;7():10023.

Genetic analysis of advanced glycation end products in the DHS MIND study. Adams JN, Raffield LM, Martelle SE, Freedman BI, Langefeld CD, Carr JJ, Cox AJ, Bowden DW.. Gene. 2016;584(2):173-179.

Dopamine pathway gene variants may modulate cognitive performance in the DHS - Mind Study. Martelle SE, Raffield LM, Palmer ND, Cox AJ, Freedman BI, Hugenschmidt CE, Williamson JD, Bowden DW.. Brain Behav. 2016;6(4):e00446.

Normative values for electrochemical skin conductances and impact of ethnicity on quantitative assessment of sudomotor function. Vinik AI, Smith AG, Singleton JR, Callaghan B, Freedman BI, Tuomilehto J, Bordier L, Bauduceau B, Roche F.. Diabetes Technol Ther. 2016;18(6):391-398.

Deceased-donor apolipoprotein L1 renal-risk variants have minimal effects on liver transplant outcomes. Dorr CR, Freedman BI, Hicks PJ, Brown WM, Russell GB, Julian BA, Pastan SO, Gautreaux MD, Muthusamy A, Chinnakotla S, Hauptfeld V, Bray RA, Kirk AD, Divers J, Israni AK.. PLoS One. 2016;11(4):e0152775.

Admixture mapping of serum vitamin D and parathyroid hormone concentrations in the African American-Diabetes Heart Study. Palmer ND, Divers J, Lu L, Register TC, Carr JJ, Hicks PJ, Smith SC, Xu J, Judd SE, Irvin MR, Gutierrez OM, Bowden DW, Wagenknecht LE, Langefeld CD, Freedman BI.. Bone. 2016;87():71-77.

APOL1 renal-risk genotypes associate with longer hemodialysis survival in prevalent nondiabetic African American patients with end-stage renal disease. Ma L, Langefeld CD, Comeau ME, Bonomo JA, Rocco MV, Burkart JM, Divers J, Palmer ND, Hicks PJ, Bowden DW, Lea JP, Krisher JO, Clay MJ, Freedman BI.. Kidney Int. 2016;90(2):389-395.

Selecting SNPs informative for African, American Indian and European Ancestry: application to the Family Investigation of Nephropathy and Diabetes (FIND). Williams RC, Elston RC, Kumar P, Knowler WC, Abboud HE, Adler S, Bowden DW, Divers J, Freedman BI, Igo RP Jr, Ipp E, Iyengar SK, Kimmel PL, Klag MJ, Kohn O, Langefeld CD, Leehey DJ, Nelson RG, Nicholas SB, Pahl MV, Parekh RS, Rotter JI, Schelling JR,.. BMC Genomics. 2016;17(1):325.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Nephrology

Clinical Interests

Atherosclerosis, Nephrology, Genetic Factors in Kidney Disease and Diabetes, Kidney Disease, Diabetes, Clinical Nephrology, Hypertension
Barry I. Freedman, M.D.
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