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Barry I. Freedman, M.D.Wake Forest School of Medicine

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Barry I. Freedman, M.D.

Section Chief,
Professor,







Clinical Interests

Atherosclerosis, Nephrology, Genetic Factors in Kidney Disease and Diabetes, Kidney Disease, Diabetes, Clinical Nephrology, Hypertension

Contact Information

New Patient Appointments: 336-716-WAKE
Returning Patient Appointments: 336-716-6192
Department: 336-716-4650

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Education & Training

  • B.S., CUNY Brooklyn College, 1980
  • M.D., SUNY Brooklyn College of Medicine, 1984
  • Residency, Internal Medicine, Eastern Virginia Medical Schoo, 1987
  • Fellowship, WFU School of Medicine, 1989

Board Certifications

  • American Board of Internal Medicine, Internal Medicine
  • American Board of Internal Medicine, Internal Medicine, Nephrology

Memberships

  • Int'L Society Of Nephrology
  • Nat'L Kidney Foundation
  • North Carolina Medical Assn
  • Renal Physicians Assn
  • Am Coll Of Physicians
  • Am Heart Association
  • Am Soc Of Hypertension
  • Am Soc Of Nephrology
  • Alpha Omega Alpha

NPI Number

  • 1245215672
Barry I. Freedman, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

Barry I. Freedman, M.D.

Section Chief, Nephrology
Professor, Nephrology
Maya Angelou Center for Health Equity
Hypertension and Vascular Research Center
Center for Diabetes Research
Center for Public Health Genomics
Institute for Regenerative Medicine
Urology
Translational Science Institute

Research Interests

atherosclerosis/thrombosis, diabetes, epidemiology, genetics/genome, genomics and proteomics, hypertension, infectious diseases, minority health issues, molecular biology/molecular me, neurosciences/behavior, osteoporosis, rare diseases, transplantation

Contact Information

Academic: 336-716-6192 | Department: 336-716-4650

Media Medical Expert »

Recent Publications

Langefeld CD, Divers J, Pajewski NM, Hawfield AT, Reboussin DM, Bild DE, Kaysen GA, Kimmel PL, Raj DS, Ricardo AC, Wright JT Jr, Sedor JR, Rocco MV, Freedman BI. Apolipoprotein L1 gene variants associate with prevalent kidney but not prevalent cardiovascular disease in the Systolic Blood Pressure Intervention Trial. Kidney Int. 2015;87(1):169-175.

Ma L, Shelness GS, Snipes JA, Murea M, Antinozzi PA, Cheng D, Saleem MA, Satchell SC, Banas B, Mathieson PW, Kretzler M, Hemal AK, Rudel LL, Petrovic S, Weckerle A, Pollak MR, Ross MD, Parks JS, Freedman BI. Localization of APOL1 protein and mRNA in the human kidney: nondiseased tissue, primary cells, and immortalized cell lines. J Am Soc Nephrol. 2015;26(2):339-348.

Freedman BI, Langefeld CD, Lu L, Palmer ND, Carrie Smith S, Bagwell BM, Hicks PJ, Xu J, Wagenknecht LE, Raffield LM, Register TC, Jeffrey Carr J, Bowden DW, Divers J. APOL1 associations with nephropathy, atherosclerosis, and all-cause mortality in African Americans with type 2 diabetes. Kidney Int. 2015;87(1):176-181.

Larsen CP, Beggs ML, Saeed M, Ambruzs JM, Cossey LN, Messias NC, Walker PD, Freedman BI. Histopathologic findings associated with APOL1 risk variants in chronic kidney disease. Mod Pathol. 2015;28(1):95-102.

Kottyan LC, Zoller EE, Bene J, Lu X, Kelly JA, Rupert AM, Lessard CJ, Vaughn SE, Marion M, Weirauch MT, Namjou B, Adler A, Rasmussen A, Glenn S, Montgomery CG, Hirschfield GM, Xie G, Coltescu C, Amos C, Li H, Ice JA, Nath SK, Mariette X, Bowman S,. The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share. Hum Mol Genet. 2015;24(2):582-596.

Sink KM, Divers J, Whitlow CT, Palmer ND, Smith SC, Xu J, Hugenschmidt CE, Wagner BC, Williamson JD, Bowden DW, Maldjian JA, Freedman BI. Cerebral structural changes in diabetic kidney disease: African American-Diabetes Heart Study MIND. Diabetes Care. 2015;38(2):206-212.

Palmer ND, Ng MC, Langefeld CD, Divers J, Lea JP, Okusa MD, Kimberly RP, Bowden DW, Freedman BI. Lack of association of the APOL1 G3 haplotype in African Americans with ESRD. J Am Soc Nephrol. 2015;26(5):1021-1025.

Yeo NC, O'Meara CC, Bonomo JA, Veth KN, Tomar R, Flister MJ, Drummond IA, Bowden DW, Freedman BI, Lazar J, Link BA, Jacob HJ. Shroom3 contributes to the maintenance of the glomerular filtration barrier integrity. Genome Res. 2015;25(1):57-65.

Zhang K, Mir SA, Hightower CM, Miramontes-Gonzalez JP, Maihofer AX, Chen Y, Mahata SK, Nievergelt CM, Schork NJ, Freedman BI, Vaingankar SM, O'Connor DT. Molecular mechanism for hypertensive renal disease: differential regulation of chromogranin A expression at 3'-untranslated region polymorphism C+87T by microRNA-107. J Am Soc Nephrol. 2015;26(8):1816-1825.

Raffield LM, Cox AJ, Hugenschmidt CE, Freedman BI, Langefeld CD, Williamson JD, Hsu F, Maldjian JA, Bowden DW. Heritability and genetic association analysis of neuroimaging measures in the Diabetes Heart Study. Neurobiol Aging. 2015;36(3):1602.e7-15.

Larsen CP, Freedman BI. Apolipoprotein L1-associated nephropathy and the future of renal diagnostics [editorial]. J Am Soc Nephrol. 2015;26(6):1232-1235.

Martins M, Williams AH, Comeau M, Marion M, Ziegler JT, Freedman BI, Merrill JT, Glenn SB, Kelly JA, Sivils KM, James JA, Guthridge JM, Alarcon-Riquelme ME, Bae SC, Kim JH, Kim D, Anaya JM, Boackle SA, Criswell LA, Kimberly RP, Alarcon GS, Brown EE,. Genetic association of CD247 (CD3zeta) with SLE in a large-scale multiethnic study. Genes Immun. 2015;16(2):142-150.

Vaughn SE, Foley C, Lu X, Patel ZH, Zoller EE, Magnusen AF, Williams AH, Ziegler JT, Comeau ME, Marion MC, Glenn SB, Adler A, Shen N, Nath S, Stevens AM, Freedman BI, Tsao BP, Jacob CO, Kamen DL, Brown EE, Gilkeson GS, Alarcon GS,. Lupus risk variants in the PXK locus alter B-cell receptor internalization. Front Genet. 2015;5():450.

Raffield LM, Cox AJ, Carr JJ, Freedman BI, Hicks PJ, Langefeld CD, Hsu FC, Bowden DW. Analysis of a cardiovascular disease genetic risk score in the Diabetes Heart Study. Acta Diabetol. 2015;52(4):743-751.

Freedman BI, Julian BA, Pastan SO, Israni AK, Schladt D, Gautreaux MD, Hauptfeld V, Bray RA, Gebel HM, Kirk AD, Gaston RS, Rogers J, Farney AC, Orlando G, Stratta RJ, Mohan S, Ma L, Langefeld CD, Hicks PJ, Palmer ND, Adams PL,. Apolipoprotein L1 gene variants in deceased organ donors are associated with renal allograft failure. Am J Transplant. 2015;15(6):1615-1622.

Murea M, Hsu FC, Cox AJ, Hugenschmidt CE, Xu J, Adams JN, Raffield LM, Whitlow CT, Maldjian JA, Bowden DW, Freedman BI. Structural and functional assessment of the brain in European Americans with mild-to-moderate kidney disease: Diabetes Heart Study-MIND. Nephrol Dial Transplant. 2015;30(8):1322-1329.

Freedman BI, Julian BA. Should kidney donors be genotyped for APOL1 risk alleles? [editorial]. Kidney Int. 2015;87(4):671-673.

Lu X, Zoller EE, Weirauch MT, Wu Z, Namjou B, Williams AH, Ziegler JT, Comeau ME, Marion MC, Glenn SB, Adler A, Shen N, Nath SK, Stevens AM, Freedman BI, Tsao BP, Jacob CO, Kamen DL, Brown EE, Gilkeson GS, Alarcon GS, Reveille JD,. Lupus risk variant increases pSTAT1 binding and decreases ETS1 expression. Am J Hum Genet. 2015;96(5):731-739.

Ma J, Divers J, Palmer ND, Julian BA, Israni AK, Schladt D, Pastan SO, Chattrabhuti K, Gautreaux MD, Hauptfeld V, Bray RA, Kirk AD, Brown WM, Gaston RS, Rogers J, Farney AC, Orlando G, Stratta RJ, Guan M, Palanisamy A, Reeves-Daniel AM, Bowden DW,. Deceased donor multidrug resistance protein 1 and caveolin 1 gene variants may influence allograft survival in kidney transplantation. Kidney Int. 2015;():.

Palanisamy A, Persad P, Koty PP, Douglas LL, Stratta RJ, Rogers J, Reeves-Daniel AM, Orlando G, Farney AC, Beaty MW, Pettenati MJ, Iskandar SS, Grier DD, Kaczmorski SA, Doares WH, Gautreaux MD, Freedman BI, Powell BL. Donor-derived myeloid sarcoma in two kidney transplant recipients from a single donor. Case Rep Nephrol. 2015;2015():821346.

Freedman BI, Smith SC, Bagwell BM, Xu J, Bowden DW, Divers J. Electrochemical skin conductance (ESC) associates with diabetic kidney disease (DKD) in European Americans (EAs) and African Americans (AAs) with type 2 diabetes mellitus (T2D) [abstract]. Diabetes. 2015;64(Suppl 1):A157.

Rotimi CN, Shriner D, Adeyemo A, Freedman BI. Renal risk genotype in APOL1 protects against diabetes and diabetic nephropathy [abstract]. Diabetes. 2015;64(Suppl 1):A465-A466.

Keaton JM, Ng MC, Palmer N, Pankow J, Fornage M, Wilson JG, Correa A, Rasmussen-Torvik LJ, Rotter JI, Rich SS, Wagenknecht LE, Freedman BI, Bowden DW. Genome-wide gene-gene interaction with insulin secretion loci reveals novel loci contributing to type 2 diabetes etiology in African Americans [abstract]. Diabetes. 2015;64(Suppl 1):A465.

Sajuthi S, Sharma N, McWilliams D, Chou J, Comeau M, Palmer ND, Ma L, Calles J, Demons J, Rogers S, Beal J, Menon L, Kouba E, Davis D, Byers J, Burris M, Byerly SJ, Easter L, Bowden DW, Freedman BI, Langefeld CD, Das SK. eQTL analysis of adipose and muscle in African Americans identifies genetic regulators for type 2 diabetes and obesity-associated genes [abstract]. Diabetes. 2015;64(Suppl 1):A82.

Sharma NK, Sajuthi S, Chou J, Ma L, Calles J, Demons J, Rogers S, McWilliams D, Beal J, Comeau M, Palmer ND, Menon L, Kouba E, Davis D, Byers J, Burris M, Byerly SJ, Easter L, Bowden DW, Freedman BI, Langefeld CD, Das Sk. Transcriptional profiles of adipose and muscle tissue are associated with insulin sensitivity and influenced by genetic variation in African Americans [abstract]. Diabetes. 2015;64(Suppl 1):A456.

Bentley AR, Divers J, Shriner D, Doumatey AP, Gutierrez OM, Adeyemo AA, Freedman BI, Rotimi CN. APOL1 G1 genotype modifies the association between HDLC and kidney function in African Americans. BMC Genomics. 2015;16():421.

Cheng D, Weckerle A, Yu Y, Ma L, Zhu X, Murea M, Freedman BI, Parks JS, Shelness GS. Biogenesis and cytotoxicity of APOL1 renal-risk variant proteins in hepatocytes and hepatoma cells. J Lipid Res. 2015;56(8):1583-1593.

Freedman BI. APOL1 and kidney disease: new insights leading to novel therapies [editorial]. Am J Kidney Dis. 2015;66(1):9-11.

Gutierrez OM, Judd SE, Irvin MR, Zhi D, Limdi N, Palmer ND, Rich SS, Sale MM, Freedman BI. APOL1 nephropathy risk variants are associated with altered high-density lipoprotein profiles in African Americans. Nephrol Dial Transplant. 2015;():.

Raffield LM, Hsu FC, Cox AJ, Carr JJ, Freedman BI, Bowden DW. Predictors of all-cause and cardiovascular disease mortality in type 2 diabetes: Diabetes Heart Study. Diabetol Metab Syndr. 2015;7():58.

Parsa A, Freedman BI. Generalizability of genetic findings related to kidney function and albuminuria [editorial]. Clin J Am Soc Nephrol. 2014;9(1):8-11.

Hill CJ, Maxwell AP, Cardwell CR, Freedman BI, Tonelli M, Emoto M, Inaba M, Hayashino Y, Fukuhara S, Okada T, Drechsler C, Wanner C, Casula A, Adler AI, Lamina C, Kronenberg F, Streja E, Kalantar-Zadeh K, Fogarty DG. Glycated hemoglobin and risk of death in diabetic patients treated with hemodialysis: a meta-analysis. Am J Kidney Dis. 2014;63(1):84-94.

Freedman BI, Bowden DW, Smith SC, Xu J, Divers J. Relationships between electrochemical skin conductance and kidney disease in Type 2 diabetes. J Diabetes Complications. 2014;28(1):56-60.

Palmer ND, Ng MC, Hicks PJ, Mudgal P, Langefeld CD, Freedman BI, Bowden DW. Evaluation of candidate nephropathy susceptibility genes in a genome-wide association study of African American diabetic kidney disease. PLoS One. 2014;9(2):e88273.

Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI. Sclerostin is positively associated with bone mineral density in men and women and negatively associated with carotid calcified atherosclerotic plaque in men from the African American-Diabetes Heart Study. J Clin Endocrinol Metab. 2014;99(1):315-321.

Divers J, Palmer ND, Lu L, Langefeld CD, Rocco MV, Hicks PJ, Murea M, Ma L, Bowden DW, Freedman BI. Gene-gene interactions in APOL1-associated nephropathy. Nephrol Dial Transplant. 2014;29(3):587-594.

Katz DH, Selvaraj S, Aguilar FG, Martinez EE, Beussink L, Kim KY, Peng J, Sha J, Irvin MR, Eckfeldt JH, Turner ST, Freedman BI, Arnett DK, Shah SJ. Association of low-grade albuminuria with adverse cardiac mechanics: findings from the Hypertension Genetic Epidemiology Network (HyperGEN) Study. Circulation. 2014;129(1):42-50.

Divers J, Freedman BI. Genetics in kidney disease in 2013: susceptibility genes for renal and urological disorders. Nat Rev Nephrol. 2014;10(2):69-70.

Freedman BI, Langefeld CD, Andringa KK, Croker JA, Williams AH, Garner NE, Birmingham DJ, Hebert LA, Hicks PJ, Segal MS, Edberg JC, Brown EE, Alarcon GS, Costenbader KH, Comeau ME, Criswell LA, Harley JB, James JA, Kamen DL,. End-stage renal disease in African Americans with lupus nephritis is associated with APOL1. Arthritis Rheum. 2014;66(2):390-396.

Kaskel F, Batlle D, Beddhu S, Daugirdas J, Feldman H, Ferris M, Fine L, Freedman BI, Kimmel PL, Flessner MF, Star RA. Improving CKD therapies and care: a national dialogue. Clin J Am Soc Nephrol. 2014;9(4):815-817.

Cox AJ, Hsu FC, Ng MC, Langefeld CD, Freedman BI, Carr JJ, Bowden DW. Genetic risk score associations with cardiovascular disease and mortality in the Diabetes Heart Study. Diabetes Care. 2014;37(4):1157-1164.

Guthridge JM, Lu R, Sun H, Sun C, Wiley GB, Dominguez N, Macwana SR, Lessard CJ, Kim-Howard X, Cobb BL, Kaufman KM, Kelly JA, Langefeld CD, Adler AJ, Harley IT, Merrill JT, Gilkeson GS, Kamen DL, Niewold TB, Brown EE, Edberg JC, Petri MA,. Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription. Am J Hum Genet. 2014;94(4):586-598.

Murea M, James KM, Russell GB, Byrum GV III, Yates JE, Tuttle NS, Bleyer AJ, Burkart JM, Freedman BI. Risk of catheter-related bloodstream infection in elderly patients on hemodialysis. Clin J Am Soc Nephrol. 2014;9(4):764-770.

Cox AJ, Azeem A, Yeboah J, Soliman EZ, Aggarwal SR, Bertoni AG, Carr JJ, Freedman BI, Herrington DM, Bowden DW. Heart rate-corrected QT interval is an independent predictor of all-cause and cardiovascular mortality in individuals with type 2 diabetes: the Diabetes Heart Study. Diabetes Care. 2014;37(5):1454-1461.

Adams JN, Raffield LM, Freedman BI, Langefeld CD, Ng MC, Carr JJ, Cox AJ, Bowden DW. Analysis of common and coding variants with cardiovascular disease in the diabetes heart study. Cardiovasc Diabetol. 2014;13(1):77.

Cooke Bailey JN, Palmer ND, Ng MC, Bonomo JA, Hicks PJ, Hester JM, Langefeld CD, Freedman BI, Bowden DW. Analysis of coding variants identified from exome sequencing resources for association with diabetic and non-diabetic nephropathy in African Americans. Hum Genet. 2014;133(6):769-779.

Palanisamy A, Reeves-Daniel AM, Freedman BI. The impact of APOL1, CAV1, and ABCB1 gene variants on outcomes in kidney transplantation: donor and recipient effects. Pediatr Nephrol. 2014;29(9):1485-1492.

Freedman BI, Divers J, High KP. The authors reply [to editorial comment on 'JC polyoma virus and kidney disease'] [letter]. Kidney Int. 2014;85(5):1242-1243.

Bonomo JA, Ng MC, Palmer ND, Keaton JM, Larsen CP, Hicks PJ, Langefeld CD, Freedman BI, Bowden DW. Coding variants in nephrin (NPHS1) and susceptibility to nephropathy in African Americans. Clin J Am Soc Nephrol. 2014;9(8):1434-1440.

Chung SA, Brown EE, Williams AH, Ramos PS, Berthier CC, Bhangale T, Alarcon-Riquelme ME, Behrens TW, Criswell LA, Graham DC, Demirci FY, Edberg JC, Gaffney PM, Harley JB, Jacob CO, Kamboh M, Kelly JA, Manzi S, Moser-Sivils KL, Russell LP,. Lupus nephritis susceptibility loci in women with systemic lupus erythematosus. J Am Soc Nephrol. 2014;25(12):2859-2870.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Nephrology

Clinical Interests

Atherosclerosis, Nephrology, Genetic Factors in Kidney Disease and Diabetes, Kidney Disease, Diabetes, Clinical Nephrology, Hypertension
Barry I. Freedman, M.D.
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