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Barry I. Freedman, M.D.Wake Forest School of Medicine

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Barry I. Freedman, M.D.

Section Chief,
Professor,



Ctr for Public Health Genomics



Clinical Specialties

Atherosclerosis, Genetic Factors in Kidney Disease and Diabetes, Diabetes, Clinical Nephrology, Hypertension, Kidney Disease, Nephrology

Contact Information

New Patient Appointments: 336-716-WAKE
Returning Patient Appointments: 336-716-6192
Department: 336-716-4650

Insurance Accepted »

Media Medical Expert »

Education & Training

  • B.S., CUNY Brooklyn College , 1980
  • M.D., SUNY Brooklyn College of Medicine , 1984
  • Residency, Internal Medicine, Eastern Virginia Medical Schoo, 1987
  • Fellowship, WFU School of Medicine, 1989

Board Certifications

  • American Board of Internal Medicine, Internal Medicine, Internal Medicine - Internal Medicine
  • American Board of Internal Medicine, Internal Medicine - Nephrology

Memberships

  • Int'L Society Of Nephrology
  • Nat'L Kidney Foundation
  • North Carolina Medical Assn
  • Renal Physicians Assn
  • Am Coll Of Physicians
  • Am Heart Association
  • Am Soc Of Hypertension
  • Am Soc Of Nephrology
  • Alpha Omega Alpha

NPI Number

  • 1245215672
Barry I. Freedman, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

Barry I. Freedman, M.D.

Section Chief, Nephrology
Professor, Nephrology
Maya Angelou Center for Health Equity
Hypertension and Vascular Research Center
Center for Diabetes Research
Ctr for Public Health Genomics
Institute for Regenerative Medicine
Urology
Translational Science Institute

Research Interests

genetics/genome, hypertension, minority health issues, molecular biology/molecular me, transplantation, vascular diseases

Contact Information

Academic: 336-716-6192 | Department: 336-716-4650

Media Medical Expert »

Recent Publications

Parsa A, Freedman BI. Generalizability of genetic findings related to kidney function and albuminuria [editorial]. Clin J Am Soc Nephrol. 2014;9(1):8-11.

Hill CJ, Maxwell AP, Cardwell CR, Freedman BI, Tonelli M, Emoto M, Inaba M, Hayashino Y, Fukuhara S, Okada T, Drechsler C, Wanner C, Casula A, Adler AI, Lamina C, Kronenberg F, Streja E, Kalantar-Zadeh K, Fogarty DG. Glycated hemoglobin and risk of death in diabetic patients treated with hemodialysis: a meta-analysis. Am J Kidney Dis. 2014;63(1):84-94.

Freedman BI, Bowden DW, Smith SC, Xu J, Divers J. Relationships between electrochemical skin conductance and kidney disease in Type 2 diabetes. J Diabetes Complications. 2014;28(1):56-60.

Palmer ND, Ng MC, Hicks PJ, Mudgal P, Langefeld CD, Freedman BI, Bowden DW. Evaluation of candidate nephropathy susceptibility genes in a genome-wide association study of African American diabetic kidney disease. PLoS One. 2014;9(2):e88273.

Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI. Sclerostin is positively associated with bone mineral density in men and women and negatively associated with carotid calcified atherosclerotic plaque in men from the African American-Diabetes Heart Study. J Clin Endocrinol Metab. 2014;99(1):315-321.

Divers J, Palmer ND, Lu L, Langefeld CD, Rocco MV, Hicks PJ, Murea M, Ma L, Bowden DW, Freedman BI. Gene-gene interactions in APOL1-associated nephropathy. Nephrol Dial Transplant. 2014;29(3):587-594.

Katz DH, Selvaraj S, Aguilar FG, Martinez EE, Beussink L, Kim KY, Peng J, Sha J, Irvin MR, Eckfeldt JH, Turner ST, Freedman BI, Arnett DK, Shah SJ. Association of low-grade albuminuria with adverse cardiac mechanics: findings from the Hypertension Genetic Epidemiology Network (HyperGEN) Study. Circulation. 2014;129(1):42-50.

Divers J, Freedman BI. Genetics in kidney disease in 2013: susceptibility genes for renal and urological disorders. Nat Rev Nephrol. 2014;10(2):69-70.

Freedman BI, Langefeld CD, Andringa KK, Croker JA, Williams AH, Garner NE, Birmingham DJ, Hebert LA, Hicks PJ, Segal MS, Edberg JC, Brown EE, Alarcon GS, Costenbader KH, Comeau ME, Criswell LA, Harley JB, James JA, Kamen DL,. End-stage renal disease in African Americans with lupus nephritis is associated with APOL1. Arthritis Rheum. 2014;66(2):390-396.

Kaskel F, Batlle D, Beddhu S, Daugirdas J, Feldman H, Ferris M, Fine L, Freedman BI, Kimmel PL, Flessner MF, Star RA. Improving CKD therapies and care: a national dialogue. Clin J Am Soc Nephrol. 2014;9(4):815-817.

Cox AJ, Hsu FC, Ng MC, Langefeld CD, Freedman BI, Carr JJ, Bowden DW. Genetic risk score associations with cardiovascular disease and mortality in the Diabetes Heart Study. Diabetes Care. 2014;37(4):1157-1164.

Guthridge JM, Lu R, Sun H, Sun C, Wiley GB, Dominguez N, Macwana SR, Lessard CJ, Kim-Howard X, Cobb BL, Kaufman KM, Kelly JA, Langefeld CD, Adler AJ, Harley IT, Merrill JT, Gilkeson GS, Kamen DL, Niewold TB, Brown EE, Edberg JC, Petri MA,. Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription. Am J Hum Genet. 2014;94(4):586-598.

Murea M, James KM, Russell GB, Byrum GV III, Yates JE, Tuttle NS, Bleyer AJ, Burkart JM, Freedman BI. Risk of catheter-related bloodstream infection in elderly patients on hemodialysis. Clin J Am Soc Nephrol. 2014;9(4):764-770.

Divers J, Freedman BI. Susceptibility genes for renal and urological disorders. Nat Rev Nephrol. 2014;10(2):69-70.

Cox AJ, Azeem A, Yeboah J, Soliman EZ, Aggarwal SR, Bertoni AG, Carr JJ, Freedman BI, Herrington DM, Bowden DW. Heart rate-corrected QT interval is an independent predictor of all-cause and cardiovascular mortality in individuals with type 2 diabetes: the Diabetes Heart Study. Diabetes Care. 2014;37(5):1454-1461.

Adams JN, Raffield LM, Freedman BI, Langefeld CD, Ng MC, Carr JJ, Cox AJ, Bowden DW. Analysis of common and coding variants with cardiovascular disease in the diabetes heart study. Cardiovasc Diabetol. 2014;13(1):77.

Cooke Bailey JN, Palmer ND, Ng MC, Bonomo JA, Hicks PJ, Hester JM, Langefeld CD, Freedman BI, Bowden DW. Analysis of coding variants identified from exome sequencing resources for association with diabetic and non-diabetic nephropathy in African Americans. Hum Genet. 2014;133(6):769-779.

Freedman BI, Divers J, High KP. The authors reply [to editorial comment on 'JC polyoma virus and kidney disease'] [letter]. Kidney Int. 2014;85(5):1242-1243.

Bonomo JA, Ng MC, Palmer ND, Keaton JM, Larsen CP, Hicks PJ, Langefeld CD, Freedman BI, Bowden DW. Coding variants in nephrin (NPHS1) and susceptibility to nephropathy in African Americans. Clin J Am Soc Nephrol. 2014;9():.

Chung SA, Brown EE, Williams AH, Ramos PS, Berthier CC, Bhangale T, Alarcon-Riquelme ME, Behrens TW, Criswell LA, Graham DC, Demirci FY, Edberg JC, Gaffney PM, Harley JB, Jacob CO, Kamboh M, Kelly JA, Manzi S, Moser-Sivils KL, Russell LP,. Lupus nephritis susceptibility loci in women with systemic lupus erythematosus. J Am Soc Nephrol. 2014;():.

Cox AJ, Hugenschmidt CE, Raffield LM, Langefeld CD, Freedman BI, Williamson JD, Hsu FC, Bowden DW. Heritability and genetic association analysis of cognition in the Diabetes Heart Study. Neurobiol Aging. 2014;35(8):1958e3-e12.

Bonomo JA, Palmer ND, Hicks PJ, Lea JP, Okusa MD, Langefeld CD, Bowden DW, Freedman BI. Complement factor H gene associations with end-stage kidney disease in African Americans. Nephrol Dial Transplant. 2014;29(7):1409-1414.

Pirkle JL, Palavecino EL, Freedman BI. Lactobacillus species can cause a false-positive test for hematuria on dipstick urinalysis [letter]. Am J Med. 2013;126(1):e3-e4.

Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI. Plasma Dickkopf1 (DKK1) concentrations negatively associate with atherosclerotic calcified plaque in African-Americans with type 2 diabetes. J Clin Endocrinol Metab. 2013;98(1):E60-E65.

Lipkowitz MS, Freedman BI, Langefeld CD, Comeau ME, Bowden DW, Kao WH, Astor BC, Bottinger EP, Iyengar SK, Klotman PE, Freedman RG, Zhang W, Parekh RS, Choi MJ, Nelson GW, Winkler CA, Kopp JB. Apolipoprotein L1 gene variants associate with hypertension-attributed nephropathy and the rate of kidney function decline in African Americans. Kidney Int. 2013;83(1):114-120.

Deng Y, Zhao J, Sakurai D, Kaufman KM, Edberg JC, Kimberly RP, Kamen DL, Gilkeson GS, Jacob CO, Scofield RH, Langefeld CD, Kelly JA, Ramsey-Goldman R, Petri MA, Reveille JD, Vila LM, Alarcon GS, Vyse TJ, Pons-Estel BA,. MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus. PLoS Genet. 2013;9(2):e1003336.

Molineros JE, Maiti AK, Sun C, Looger LL, Han S, Kim-Howard X, Glenn S, Adler A, Kelly JA, Niewold TB, Gilkeson GS, Brown EE, Alarcon GS, Edberg JC, Petri M, Ramsey-Goldman R, Reveille JD, Vila LM, Freedman BI, Tsao BP,. Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production. PLoS Genet. 2013;9(2):e1003222.

Ng MCY, Saxena R, Li J, Palmer ND, Dimitrov L, Xu J, Rasmussen-Torvik LJ, Zmuda JM, Siscovick DS, Patel SR, Crook ED, Sims M, Chen YD, Bertoni AG, Li M, Grant SF, Dupuis J, Meigs JB, Psaty BM, Pankow JS, Langefeld CD,. Transferability and fine mapping of type 2 diabetes loci in African Americans: the Candidate Gene Association Resource Plus Study. Diabetes. 2013;62(3):965-976.

Divers J, Palmer ND, Lu L, Register TC, Carr JJ, Hicks PJ, Hightower RC, Smith SC, Xu J, Cox AJ, Hruska KA, Bowden DW, Lewis CE, Heiss G, Province MA, Borecki IB, Kerr KF, Chen YD, Palmas W, Rotter JI, Wassel CL, Bertoni AG,. Admixture mapping of coronary artery calcified plaque in African Americans with type 2 diabetes mellitus. Circ Cardiovasc Genet. 2013;6(1):97-105.

Agarwal S, Cox AJ, Herrington DM, Jorgensen NW, Xu J, Freedman BI, Carr JJ, Bowden DW. Coronary calcium score predicts cardiovascular mortality in diabetes: Diabetes Heart Study. Diabetes Care. 2013;36(4):972-977.

Nguyen KD, Pihur V, Ganesh SK, Rakha A, Cooper RS, Hunt SC, Freedman BI, Coresh J, Kao WH, Morrison AC, Boerwinkle E, Ehret GB, Chakravarti A. Effects of rare and common blood pressure gene variants on essential hypertension: results from the Family Blood Pressure Program, CLUE, and Atherosclerosis Risk in Communities studies. Circ Res. 2013;112(2):318-326.

Richardson SI, Freedman BI, Ellison DH, Rodriguez CJ. Salt sensitivity: a review with a focus on non-Hispanic blacks and Hispanics. J Am Soc Hypertens. 2013;7(2):170-179.

Adams JN, Cox AJ, Freedman BI, Langefeld CD, Carr JJ, Bowden DW. Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the Diabetes Heart Study. Cardiovasc Diabetol. 2013;12():31.

Divers J, Wagenknecht LE, Bowden DW, Carr JJ, Hightower RC, Smith SC, Xu J, Langefeld CD, Freedman BI. Albuminuria associates with calcified atherosclerotic plaque in African Americans with diabetes [letter]. Diabetes Care. 2013;36(3):e34-e35.

Pirkle JL, Freedman BI. Hypertension and chronic kidney disease: controversies in pathogenesis and treatment. Minerva Urol Nefrol. 2013;65(1):37-50.

Robinson TW, Freedman BI. Assessing glycemic control in diabetic patients with severe nephropathy. J Ren Nutr. 2013;23(3):199-202.

Kaufman KM, Zhao J, Kelly JA, Hughes T, Adler A, Sanchez E, Ojwang JO, Langefeld CD, Ziegler JT, Williams AH, Comeau ME, Marion MC, Glenn SB, Cantor RM, Grossman JM, Hahn BH, Song YW, Yu CY, James JA, Guthridge JM,. Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups. Ann Rheum Dis. 2013;72(3):437-444.

Ma L, Murea M, Snipes JA, Marinelarena A, Kruger J, Hicks PJ, Langberg KA, Bostrom MA, Cooke JN, Suzuki D, Babazono T, Uzu T, Tang SC, Mondal AK, Sharma NK, Kobes S, Antinozzi PA, Davis M, Das SK, Rasouli N, Kern PA,. An ACACB variant implicated in diabetic nephropathy associates with body mass index and gene expression in obese subjects. PLoS One. 2013;8(2):e56193.

Register TC, Divers J, Bowden DW, Carr JJ, Lenchik L, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Hruska KA, Langefeld CD, Freedman BI. Relationships between serum adiponectin and bone density, adiposity and calcified atherosclerotic plaque in the African American-Diabetes Heart Study. J Clin Endocrinol Metab. 2013;98(5):1916-1922.

Palmer ND, Freedman BI. Diabetic nephropathy: FRMD3 in diabetic nephropathy-guilt by association. Nat Rev Nephrol. 2013;9(6):313-314.

Monda KL, Chen GK, Taylor KC, Ng MCY, Liu Y, Freedman BI, Howard TD, Langefeld CD, Lohman K, Palmer ND, Shriner DA, Burke G, Ding J, et al. A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet. 2013;45(6):690-696.


Cox AJ, Lehtinen AB, Xu J, Langefeld CD, Freedman BI, Carr JJ, Bowden DW. Polymorphisms in the Selenoprotein S gene and subclinical cardiovascular disease in the Diabetes Heart Study. Acta Diabetol. 2013;50(3):391-399.

Cox AJ, Hugenschmidt CE, Wang PT, Hsu FC, Kenchaiah S, Daniel K, Langefeld CD, Freedman BI, Herrington DM, Carr JJ, Stacey B, Bowden DW. Usefulness of biventricular volume as a predictor of mortality in patients with diabetes mellitus (from the Diabetes Heart Study). Am J Cardiol. 2013;111(8):1152-1158.

Ramos PS, Oates JC, Kamen DL, Williams AH, Gaffney PM, Kelly JA, Kaufman KM, Kimberly RP, Niewold TB, Jacob CO, Tsao BP, Alarcon GS, Brown EE, Edberg JC, Petri MA, Ramsey-Goldman R, Reveille JD, Vila LM, James JA,. Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry. J Rheumatol. 2013;40(6):842-849.

Raffield LM, Cox AJ, Hsu FC, Ng MC, Langefeld CD, Carr JJ, Freedman BI, Bowden DW. Impact of HDL genetic risk scores on coronary artery calcified plaque and mortality in individuals with type 2 diabetes from the Diabetes Heart Study. Cardiovasc Diabetol. 2013;12():95.

Pirkle JL, Freedman BI, Fogo AB. Immune complex disease with a lupus-like pattern of deposition in an antinuclear antibody-negative patient. Am J Kidney Dis. 2013;62(1):159-164.

Cox AJ, Ng MC, Xu J, Langefeld CD, Koch KL, Dawson PA, Carr JJ, Freedman BI, Hsu FC, Bowden DW. Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study. Atherosclerosis. 2013;229(1):155-160.

Hugenschmidt CE, Hsu FC, Hayasaka S, Carr JJ, Freedman BI, Nyenhuis DL, Williamson JD, Bowden DW. The influence of subclinical cardiovascular disease and related risk factors on cognition in type 2 diabetes mellitus: the DHS-Mind study. J Diabetes Complications. 2013;27(5):422-428.

Manku H, Langefeld CD, Guerra SG, Malik TH, Alarcon-Riquelme M, Anaya JM, Bae SC, Boackle SA, Brown EE, Criswell LA, Freedman BI, Gaffney PM, Gregersen PA, Guthridge JM, Han SH, Harley JB, Jacob CO, James JA,. Trans-ancestral studies fine map the SLE-susceptibility locus TNFSF4. PLoS Genet. 2013;9(7):e1003554.

Namjou B, Kim-Howard X, Sun C, Adler A, Chung SA, Kaufman KM, Kelly JA, Glenn SB, Guthridge JM, Scofield RH, Kimberly RP, Brown EE, Alarcon GS, Edberg JC, Kim JH, Choi J, Ramsey-Goldman R, Petri MA, Reveille JD,. PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes. PLoS One. 2013;8(8):e69404.

Reeves-Daniel AM, Farney AC, Fletcher AJ, Assimos D, Westcott C, Rogers J, Stratta RJ, Rocco MV, Freedman BI. Ethnicity, medical insurance, and living kidney donation. Clin Transplant. 2013;27(4):E498-E503.


Freedman BI. APOL1 and nephropathy progression in populations of African ancestry. Semin Nephrol. 2013;33(5):425-432.

Divers J, Hugenschmidt C, Sink KM, Williamson JD, Ge Y, Smith SC, Bowden DW, Whitlow CT, Lyders E, Maldjian JA, Freedman BI. Cerebral white matter hyperintensity in African Americans and European Americans with type 2 diabetes. J Stroke Cerebrovasc Dis. 2013;22(7):e46-52.

Cox AJ, Lambird JE, Sandy An S, Register TC, Langefeld CD, Carr JJ, Freedman BI, Bowden DW. Variants in adiponectin signaling pathway genes show little association with subclinical CVD in the Diabetes Heart Study. Obesity (Silver Spring). 2013;21(9):E456-462.

Craft S, Smith C, Maldjian J, Freedman BI, Divers J. Comparison of Montreal Cognitive Assessment (MOCA) and 3MSE scores in African-Americans [abstract]. Alzheimers Dement. 2013;9(4 Suppl):P321.

Murea M, James KM, Russell GB, Bleyer AJ, Burkart JM, Freedman BI. Risk of catheter-related bloodstream infections in elderly patients on hemodialysis [abstract]. J Am Soc Nephrol. 2013;24(Abstract Suppl):396A.

Fan Y, Bonomo JA, Chuang PY, Xiao W, Mallipattu SK, Palmer ND, Bowden DW, Freedman BI, Wang N, He JC. RTN1 is a novel risk gene for kidney disease [abstract]. J Am Soc Nephrol. 2013;24(Abstract Suppl):187A.

Bonomo JA, Ng M, Freedman BI, Bowden DW. RREB1, a modulator of the renin-angiotensin system (RAS), is a novel nephropathy gene in African Americans [abstract]. J Am Soc Nephrol. 2013;24(Abstract Suppl):248A.

Bonomo JA, Ng M, Palmer ND, Freedman BI, Bowden DW. Novel coding variants in NPHS1 are associated with diabetic and all-cause end-stage kidney disease (ESKD) in African Americans [abstract]. J Am Soc Nephrol. 2013;24(Abstract Suppl):712A.

Divers J, Palmer ND, Lu L, Langefeld CD, Rocco MV, Hicks PJ, Murea M, Ma L, Bowden DW, Freedman BI. Gene-gene interactions in APOL1-associated nephropathy [abstract]. J Am Soc Nephrol. 2013;24(Abstract Suppl):67A.

Freedman BI, Divers J, Smith SC, Xu J, Bowden DW. Non-invasive assessment of electrochemical skin conductance associates with kidney function in African Americans (AA) with type 2 diabetes (T2D) [abstract]. J Am Soc Nephrol. 2013;24(Abstract Suppl):201A.

Ma L, Snipes JA, Murea M, Antinozzi PA, Shelness GS, Saleem M, Satchell SC, Banas B, Mathieson PW, Kretzler M, Petrovic S, Ross MD, Pollak MR, Rudel L, Parks JS, Freedman BI. ApoL1 protein in non-diseased human podocytes: endogenous synthesis versus uptake? [abstract]. J Am Soc Nephrol. 2013;24(Abstract Suppl):557A.

Freedman BI, Fletcher AJ, Sanghani VR, Graham A, Bailey JNC, Iltis A, King NMP. Perceptions regarding genetic testing in populations at risk for nephropathy [abstract]. J Am Soc Nephrol. 2013;24(Abstract Suppl):658A.

Caster DJ, Korte EA, Nanda SK, McLeish KR, Oliver RK, G'sell RT, Sheehan RM, Freeman DW, Coventry SC, Kelly JA, Guthridge JM, James JA, Sivils KL, Alarcon-Riquelme ME, Scofield RH, Adrianto I, Gaffney PM, Stevens AM,. ABIN1 dysfunction as a genetic basis for lupus nephritis. J Am Soc Nephrol. 2013;24(11):1743-1754.

Sakurai D, Zhao J, Deng Y, Kelly JA, Brown EE, Harley JB, Bae SC, Alarcon-Riquelme ME, Edberg JC, Kimberly RP, Ramsey-Goldman R, Petri MA, Reveille JD, Vila LM, Alarcon GS, Kaufman KM, Vyse TJ, Jacob CO, Gaffney PM,. Preferential binding to Elk-1 by SLE-associated IL10 risk allele upregulates IL10 expression. PLoS Genet. 2013;9(10):e1003870.

Parsa A, Kao WH, Xie D, Astor BC, Li M, Hsu CY, Feldman HI, Parekh RS, Kusek JW, Greene TH, Fink JC, Anderson AH, Choi MJ, Wright JT Jr, Lash JP, Freedman BI, Ojo A, Winkler CA, Raj DS, Kopp JB, He J, Jensvold NG, Tao K, Lipkowitz MS, Appel LJ. APOL1 risk variants, race, and progression of chronic kidney disease. N Engl J Med. 2013;369(23):2183-2196.

Palmer ND, Freedman BI. APOL1 and progression of nondiabetic nephropathy [editorial]. J Am Soc Nephrol. 2013;24(9):1344-1346.

Divers J, Nunez M, High KP, Murea M, Rocco MV, Ma L, Bowden DW, Hicks PJ, Spainhour M, Ornelles DA, Kleiboeker SB, Duncan K, Langefeld CD, Turner J, Freedman BI. JC polyoma virus interacts with APOL1 in African Americans with nondiabetic nephropathy. Kidney Int. 2013;84(6):1207-1213.


Thameem F, Igo RP Jr, Freedman BI, Langefeld C, Hanson RL, Schelling JR, Elston RC, Duggirala R, Nicholas SB, Goddard KA, Divers J, Guo X, Ipp E, Kimmel PL, Meoni LA, Shah VO, Smith MW, Winkler CA, Zager PG, Knowler WC, Nelson RG,. A genome-wide search for linkage of estimated glomerular filtration rate (eGFR) in the family investigation of nephropathy and diabetes (FIND). PLoS One. 2013;8(12):e81888.

Sandy An S, Palmer ND, Hanley AJ, Ziegler JT, Mark Brown W, Freedman BI, Register TC, Rotter JI, Guo X, Ida Chen YD, Wagenknecht LE, Langefeld CD, Bowden DW. Genetic analysis of adiponectin variation and its association with type 2 diabetes in African Americans. Obesity (Silver Spring). 2013;21(12):E721-E729.

Cooke Bailey JN, Lu L, Chou JW, Xu J, McWilliams DR, Howard TD, Freedman BI, Bowden DW, Langefeld CD, Palmer ND. The role of copy number variation in African Americans with Type 2 diabetes-associated end stage renal disease. J Mol Genet Med. 2013;7(2):61.

Parsa A, Fuchsberger C, Kottgen A, O'Seaghdha CM, Pattaro C, de Andrade M, Chasman DI, Teumer A, Endlich K, Olden M, Chen MH, Tin A, Kim YJ, Taliun D, Li M, Feitosa M, Gorski M, Yang Q, Hundertmark C, Foster MC, Glazer N, Isaacs A,. Common variants in Mendelian kidney disease genes and their association with renal function. J Am Soc Nephrol. 2013;24(12):2105-2117.

Maldjian JA, Whitlow CT, Saha BN, Kota G, Vandergriff C, Davenport EM, Divers J, Freedman BI, Bowden DW. Automated white matter total lesion volume segmentation in diabetes. AJNR Am J Neuroradiol. 2013;34(12):2265-2270.

Freedman BI, Fletcher AJ, Sanghani VR, Spainhour M, Graham AW, Russell GB, Cooke Bailey JN, Iltis AS, King NMP. Perceptions regarding genetic testing in populations at risk for nephropathy. Am J Nephrol. 2013;38(6):453-457.


Freedman BI, Murea M. Target organ damage in African American hypertension: role of APOL1. Curr Hypertens Rep. 2012;14(1):21-28.

Sergeant S, Hugenschmidt CE, Rudock ME, Ziegler JT, Ivester P, Ainsworth HC, Vaidya D, Case LD, Langefeld CD, Freedman BI, Bowden DW, Mathias RA, Chilton FH. Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome. Br J Nutr. 2012;107(4):547-555.

Ng MCY, Hester JM, Wing MR, Li J, Xu J, Hicks PJ, Roh BH, Lu L, Divers J, Langefeld CD, Freedman BI, Palmer ND, Bowden DW. Genome-wide association of BMI in African Americans. Obesity (Silver Spring). 2012;20(3):622-627.

Rao M, Mottl AK, Cole SA, Umans JG, Freedman BI, Bowden DW, Langefeld CD, Fox CS, Yang Q, Cupples A, Iyengar SK, Hunt SC, Trikalinos TA. Meta-analysis of genome-wide linkage scans for renal function traits. Nephrol Dial Transplant. 2012;27(2):647-656.

Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, An SS, Hester JM, Cooke JN, Bostrom MA, Rudock ME, Talbert ME, Lewis JP, Lu L, Ziegler JT, Divers J, Ng MCY, Langefeld CD, Freedman BI, Bowden DW, et al. A genome-wide association search for type 2 diabetes genes in African Americans. PLoS ONE. 2012;7(1):e29202.

Cooke JN, Ng MCY, Palmer ND, An SS, Hester JM, Freedman BI, Langefeld CD, Bowden DW. Genetic risk assessment of type 2 diabetes-associated polymorphisms in African Americans. Diabetes Care. 2012;35(2):287-292.

Reeves-Daniel AM, Freedman BI. Child-to-parent donation-consideration of age and ethnicity [letter]. Am J Transplant. 2012;12(2):502.

Bostrom MA, Kao WHL, Li M, Abboud HE, Adler SG, Iyengar SK, Kimmel PL, Hanson RL, Nicholas SB, Rasooly RS, Lu L, Hicks PJ, Langefeld CD, Bowden DW, Freedman BI, et al. Genetic association and gene-gene interaction analyses in African American dialysis patients with nondiabetic nephropathy. Am J Kidney Dis. 2012;59(2):210-221.

Hester JM, Wing MR, Li J, Palmer ND, Xu J, Hicks PJ, Roh BH, Norris JM, Wagenknecht LE, Langefeld CD, Freedman BI, Bowden DW, Ng MCY. Implication of European-derived adiposity loci in African Americans. Int J Obes (Lond). 2012;36(3):465-473.

Freedman BI, Bowden DW, Rich SS. Genetic basis of kidney disease In: Taal MW, Chertow GM, Marsden PA, Skorecki K, Yu ASL, Brenner BM, eds. Brenner & Rector's the kidney, vol 2. 9th ed. Philadelphia: Elsevier Saunders;2012: 1554-1569.

Cooke JN, Bostrom MA, Hicks PJ, Ng MCY, Hellwege JN, Comeau ME, Divers J, Langefeld CD, Freedman BI, Bowden DW. Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans. Nephrol Dial Transplant. 2012;27(4):1505-1511.

Freedman BI, Langefeld CD. The new era of APOL1-associated glomerulosclerosis. Nephrol Dial Transplant. 2012;27(4):1288-1291.

Lin CP, Adrianto I, Lessard CJ, Kelly JA, Kaufman KM, Guthridge JM, Freedman BI, Anaya J-M, Alarcon-Riquelme ME, Pons-Estel BA, Martin J, Glenn S, Adler A, Bae S-C, Park S-Y, Bang S-Y, Song Y-W, Boackle SA, Brown EE, Edberg JC,. Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis. Genes Immun. 2012;13(3):232-238.

Cox AJ, Agarwal S, Herrington DM, Carr JJ, Freedman BI, Bowden DW. C-reactive protein concentration predicts mortality in type 2 diabetes: the Diabetes Heart Study. Diabet Med. 2012;29(6):767-770.

Lessard CJ, Adrianto I, Ice JA, Wiley GB, Kelly JA, Glenn SB, Adler AJ, Rasmussen A, Williams AH, Ziegler J, Comeau ME, Marion M, Wakeland BE, Liang C, Ramos PS, Grundahl KM, Gallant CJ, alarcon-Riquelme ME, Alarcon GS, Anaya J-M, Bae S-C,. Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study. Am J Hum Genet. 2012;90(4):648-660.

Pattaro C, Kottgen A, Teumer A, Garnaas M, Boger CA, Fuchsberger C, Olden M, Chen M-H, Tin A, Taliun D, Li M, Gao X, Gorski M, Yang Q, Hundertmark C, Foster MC, Lohman K, Ding J, Andrews JS, Freedman BI, Liu Y, et al. Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genet. 2012;8(3):e1002584.

Reeves-Daniel AM, Farney A, Fletcher A, Assimos DG, Westcott CJ, Ghanta M, Stratta RJ, Rogers J, Rocco MV, Freedman BI. Race, insurance status, and living kidney donation [abstract]. Am J Transplant. 2012;12(Suppl 3):332.

Namjou B, Choi CB, Harley IT, Alarcon-Riquelme ME, Kelly JA, Glenn SB, Ojwang JO, Adler A, Kim K, Gallant CJ, Boackle SA, Criswell LA, Kimberly RP, Brown EE, Edberg J, Alarcon GS, Stevens AM, Jacob CO, Gilkeson GS, Kamen DL,. Evaluation of TRAF6 in a large multiancestral lupus cohort. Arthritis Rheum. 2012;64(6):1960-1969.

Freedman BI, Register TC. Effect of race and genetics on vitamin D metabolism, bone and vascular health. Nat Rev Nephrol. 2012;8(8):459-466.


Wang S, Adrianto I, Wiley GB, Lessard CJ, Kelly JA, Adler AJ, Glenn SB, Williams AH, Ziegler JT, Comeau ME, Marion MC, Wakeland BE, Liang C, Kaufman KM, Guthridge JM, Alarcon-Riquelme ME, Alarcon GS, Anaya J-M, Bae S-C, Kim J-H,. A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus. Genes Immun. 2012;13(5):380-387.

Palmer ND, Freedman BI. Insights into the genetic architecture of diabetic nephropathy. Curr Diab Rep. 2012;12(4):423-431.

Bowden DW, Freedman BI. The challenging search for diabetic nephropathy genes [commentary]. Diabetes. 2012;61(8):1923-1924.

Simino J, Rao DC, Freedman BI. Novel findings and future directions on the genetics of hypertension. Curr Opin Nephrol Hypertens. 2012;21(5):500-507.


Cooke JN, Bowden DW, Langefeld CD, Freedman BI. Association of MYH9/APOL1 with chronic kidney disease in a UK population [reply to letter]. Nephrol Dial Transplant. 2012;27(9):3660-3662.

Kim K, Brown EE, Choi CB, Alarcon-Riquelme ME, Kelly JA, Glenn SB, Ojwang JO, Adler A, Lee HS, Boackle SA, Criswell LA, Alarcon GS, Edberg JC, Stevens AM, Jacob CO, Gilkeson GS, Kamen DL, Tsao BP, Anaya JM, Guthridge JM, Nath SK, Richardson B,. Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries. Ann Rheum Dis. 2012;71(11):1809-1814.

Bostrom MA, Perlegas P, Lu L, Hicks PJ, Hawkins G, Ng MC, Langefeld CD, Freedman BI, Bowden DW. Relevance of the ACTN4 gene in African-Americans with non-diabetic end-stage renal disease. Am J Nephrol. 2012;36(3):252-260.

Murea M, Moran T, Russell GB, Shihabi ZK, Byers JR, Andries L, Bleyer AJ, Freedman BI. Glycated albumin, not hemoglobin A1c, predicts cardiovascular hospitalization and length of stay in diabetic patients on dialysis. Am J Nephrol. 2012;36(5):488-496.

Freedman BI, Langefeld CD, Turner J, Nunez M, High KP, Spainhour M, Hicks PJ, Bowden DW, Reeves-Daniel AM, Murea M, Rocco MV, Divers J. Association of APOL1 variants with mild kidney disease in the first-degree relatives of African American patients with non-diabetic end-stage renal disease. Kidney Int. 2012;82(7):805-811.

Adrianto I, Wang S, Wiley GB, Lessard CJ, Kelly JA, Adler AJ, Glenn SB, Williams AH, Ziegler JT, Comeau ME, Marion MC, Wakeland BE, Liang C, Kaufman KM, Guthridge JM, Alarcon-Riquelme ME, Alarcon GS, Anaya JM, Bae SC, Kim JH,. Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus. Arthritis Rheum. 2012;64(11):3695-3705.

Hawfield AT, Freedman BI. Preeclampsia and risk for subsequent ESRD in populations of European ancestry [editorial]. Clin J Am Soc Nephrol. 2012;7(11):1743-1745.

Murea M, Register TC, Divers J, Bowden DW, Carr JJ, Hightower CR, Xu J, Smith SC, Hruska KA, Langefeld CD, Freedman BI. Relationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study. BMC Nephrol. 2012;13(1):148.

Zaitlen N, Lindstrom S, Pasaniuc B, Cornelis M, Genovese G, Pollack S, Barton A, Bickeboller H, Bowden DW, Eyre S, Freedman BI, Friedman DJ, Field JK, Groop L, Haugen A, Heinrich J, Henderson BE, Hicks PJ, Hocking LJ,. Informed conditioning on clinical covariates increases power in case-control association studies. PLoS Genet. 2012;8(11):e1003032.

Deng Y, Zhao J, Sakurai D, Kaufman KM, Edberg JC, Kimberly RP, Kamen DL, Gilkeson GS, Jacob CO, Scofield RH, Langefeld CD, Kelly JA, Alarcun-Riquelme ME, Harley JB, Vyse TJ, Freedman BI, Gaffney PM, Sivils KM, James JA,. The SLE-associated TLR7 variant confers differential gene expression modulated by microRNA-3148 [abstract]. Arthritis Rheum. 2012;64(Suppl 10):S689.

Edberg JC, Duarte CW, Patki A, Brown EE, Kaufman KM, Kelly JA, Comeau ME, Alarcon-Riquelme ME, Bae S-C, Criswell LA, Freedman BI, Gaffney PM, Gilkeson GS, Jacob CO, James JA, Kamen DL, Sivils KM, Niewold TB, Scofield RH,. Genetic interactions between SNP variants in C3 receptor subunits in patients with SLE [abstract]. Arthritis Rheum. 2012;64(10 Suppl):S420.

Kimberly RP, Freedman BI, Langfeld CD [sic] [Langefeld CD], Absher D, Andringa KK, Birmingham D, Brown EE, Comeau ME, Costenbader KH, Criswell LA, Edberg JC, Harley JB, James JA, Kamen DL, Merrill JT, Niewold TB, Patel N,. Apolipoprotein L1 risk variants underlie racial disparities in lupus nephritis-induced end-stage renal disease [abstract]. Arthritis Rheum. 2012;64(Suppl 10):S313.

Chasman DI, Fuchsberger C, Pattaro C, Teumer A, Boger CA, Endlich K, Olden M, Chen MH, Tin A, Taliun D, Li M, Gao X, Gorski M, Yang Q, Hundertmark C, Foster MC, O'Seaghdha CM, Glazer N, Isaacs A, Liu CT, Smith AV, O'Connell JR,. Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. Hum Mol Genet. 2012;21(24):5329-5343.

Murea M, Russell GB, Bleyer AJ, Freedman BI. Glycated albumin (GA), not hemoglobin A1c (HbA1c), predicts cardiovascular hospitalizations and length of stay (LOS) in dialysis patients with diabetes [abstract]. J Am Soc Nephrol. 2012;23():751A.

Chen Z, Freedman BI, Graham WD, Ross NA, Pollak MR, Ross MD, Murea M, Ma L, Antinozzi PA. Dose-dependent expression of ApoL1 protein sensitizes cell death pathways [abstract]. J Am Soc Nephrol. 2012;23():136A.

Freedman BI, Murea M, Rocco MV, Ma L, Bowden DW, Ornelles DA, Kleiboeker S, Langefeld CD, Turner J, Divers J. JC polyoma virus interacts with apolipoprotein L1 genetic risk in African Americans with non-diabetic nephropathy [abstract]. J Am Soc Nephrol. 2012;23():178A.

Freedman BI, Langefeld CD, Comeau ME, Hebert LA, Segal MS, Edberg J, Julian BA, Kimberly RP. Apolipoprotein L1 risk variants associate with lupus nephritis-induced end-stage renal disease in African Americans [abstract]. J Am Soc Nephrol. 2012;23():248A.

Deng Y, Zhao J, Sakurai D, Kaufman KM, Edberg JC, Kimberly RP, Kamen DL, Gilkeson GS, Jacob CO, Scofield RH, Langefeld CD, Kelly JA, Alarcon-Riquelme ME, Harley JB, Vyse TJ, Freedman BI, Gaffney PM, Sivils KM, James JA, Niewold TB,. MicroRNA-3148 modulates differential gene expression of the SLE-associated TLR7 variant [abstract]. Arthritis Res Ther. 2012;14(Suppl 3):A5.

Martins M, Williams AH, Alarcon-Riquelme M, Anaya JM, Bae SC, Boackle SA, Criswell LA, Gilkeson GS, Kamen DL, Jacob CO, James JA, Kelly JA, Moser KL, Scofield RH, Kimberly RP, Edberg JC, Vila LM, Petri M,. Genetic association of SLE with CD247 (CD3zeta) [abstract]. In: Abstracts of the American Society of Human Genetics 62nd Annual Meeting; 2012 Nov 6-10; San Francisco (CA). 2012;():454.

Freedman BI, Tuttle AB. Glycemic control in patients with diabetes and nephropathy [commentary]. JAAPA. 2012;25(11):30.

Wagenknecht LE, Divers J, Bertoni AG, Langefeld CD, Carr JJ, Bowden DW, Elbein SC [deceased], Shea S, Lewis CE, Freedman BI. Correlates of coronary artery calcified plaque in blacks and whites with type 2 diabetes. Ann Epidemiol. 2011;21(1):34-41.

Gopalakrishnan I, Iskandar SS, Daeihagh P, Divers J, Langefeld CD, Bowden DW, Hicks PJ, Rocco MV, Freedman BI. Coincident idiopathic focal segmental glomerulosclerosis collapsing variant and diabetic nephropathy in an African American homozygous for MYH9 risk variants. Hum Pathol. 2011;42(2):291-294.

Mooyaart AL, Valk EJJ, van Es LA, Bruijn JA, de Heer E, Freedman BI, Dekkers OM, Baelde HJ. Genetic associations in diabetic nephropathy: a meta-analysis. Diabetologia. 2011;54(3):544-553.

McDonough CW, Palmer ND, Hicks PJ, Roh BH, An SS, Cooke JN, Hester JM, Wing MR, Bostrom MA, Rudock ME, Lewis JP, Talbert ME, Blevins RA, Lu L, Ng MCY, Divers J, Langefeld CD, Freedman BI, Bowden DW, et al. A genome-wide association study for diabetic nephropathy genes in African Americans. Kidney Int. 2011;79(5):563-572.


Palmer ND, Hester JM, An SS, Adeyemo A, Rotimi C, Langefeld CD, Freedman BI, Ng MCY, Bowden DW. Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant. Diabetes. 2011;60(2):662-668.

Lehtinen AB, Cox AJ, Ziegler JT, Voruganti VS, Xu J, Freedman BI, Carr JJ, Comuzzie AG, Langefeld CD, Bowden DW. Genetic mapping of vascular calcified plaque loci on chromosome 16p in European Americans from the Diabetes Heart Study. Ann Hum Genet. 2011;75(2):222-235.

Lessard CJ, Adrianto I, Kelly JA, Kaufman KM, Grundahl KM, Adler A, Williams AH, Gallant CJ, Freedman BI, Langefeld CD, et al. Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study. Am J Hum Genet. 2011;88(1):83-91.

Buckalew VM, Freedman BI. Effects of race on albuminuria and risk of cardiovascular and kidney disease. Expert Rev Cardiovasc Ther. 2011;9(2):245-249.

Adrianto I, Wen F, Templeton A, Wiley G, King JB, Lessard CJ, Bates JS, Hu Y, Freedman BI, Langefeld CD, et al. Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nat Genet. 2011;43(3):253-258.

Agarwal S, Morgan T, Herrington DM, Xu J, Cox AJ, Freedman BI, Carr JJ, Bowden DW. Coronary calcium score and prediction of all-cause mortality in diabetes: the Diabetes Heart Study. Diabetes Care. 2011;34(5):1219-1224.

Reeves-Daniel AM, DePalma JA, Bleyer AJ, Rocco MV, Murea M, Adams PL, Langefeld CD, Bowden DW, Hicks PJ, Stratta RJ, Lin J-J, Kiger DF, Gautreaux MD, Divers J, Freedman BI. The APOL1 gene and allograft survival after kidney transplantation. Am J Transplant. 2011;11(5):1025-1030.

Freedman BI, Langefeld CD, Lu L, Divers J, Comeau ME, Palmer ND, Hicks PJ, Bostrom MA, Cooke JN, McDonough CW, Bowden DW, et al. Differential effects of MYH9 and APOL1 risk variants on FRMD3 association with diabetic ESRD in African Americans. PLoS Genet. 2011;7(6):e1002150.

Namjou B, Kothari PH, Kelly JA, Glenn SB, Ojwang JO, Adler A, Alarcon-Riquelme ME, Perrino FW, Freedman BI, Langefeld CD, et al. Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort. Genes Immun. 2011;12(4):270-279.

Murea M, Lu L, Ma L, Hicks PJ, Divers J, McDonough CW, Langefeld CD, Bowden DW, Freedman BI. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. Am J Nephrol. 2011;33(6):502-509.

Mathias RA, Sergeant S, Hugenschmidt CE, Ziegler JT, Ivester P, Case D, Freedman BI, Rudock ME, Langefeld CD, Bowden DW, Chilton FH, et al. The impact of FADS genetic variants on omega-6 polyunsaturated fatty acid metabolism in African Americans. BMC Genet. 2011;12():article 50.

Zhao J, Wu H, Khosravi M, Cui H, Langefeld CD, Williams AH, Comeau ME, Ziegler JT, Marion MC, Freedman BI, et al. Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. PLoS Genet. 2011;7(5):e1002079.

Tan W, Zhao J, Deng Y, Kaufman K, Kelly J, Bae S, Chang D, Yu C, Kimberly R, Freedman B, et al. Association of PPP2CA polymorphisms with SLE susceptibility in multiple ethnic groups [abstract]. Intern Med J. 2011;41(Suppl 1):1.

Igo RP Jr, Iyengar SK, Nicholas SB, Goddard KAB, Langefeld CD, Hanson RL, Duggirala R, Divers J, Bowden DW, Freedman BI, et al. Genomewide linkage scan for diabetic renal failure and albuminuria: the FIND study. Am J Nephrol. 2011;33(5):381-389.

Divers J, Register TC, Langefeld CD, Wagenknecht LE, Bowden DW, Carr JJ, Hightower RC, Xu J, Hruska KA, Freedman BI. Relationships between calcified atherosclerotic plaque and bone mineral density in African Americans with type 2 diabetes. J Bone Miner Res. 2011;26(7):1554-1560.

Freedman BI, Andries L, Shihabi ZK, Rocco MV, Byers JR, Cardona CY, Graham AD, Mauck VL, Russell GB, Bleyer AJ, et al. Glycated albumin and risk of death and hospitalizations in diabetic dialysis patients. Clin J Am Soc Nephrol. 2011;6(7):1635-1643.

Vachharajani TJ, Moossavi S, Jordan JR, Vachharajani V, Freedman BI, Burkart JM. Re-evaluating the Fistula First Initiative in octogenarians on hemodialysis. Clin J Am Soc Nephrol. 2011;6(7):1663-1667.

Irvin MR, Wineinger NE, Rice TK, Pajewski NM, Kabagambe EK, Gu CC, Pankow J, North KE, Wilk JB, Freedman BI, et al. Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN Study. PLoS ONE. 2011;6(8):e24052.

Ma L, Mondal AK, Murea M, Sharma NK, Langberg KA, Das SK, Antinozzi PA, Parks JS, Elbein SC [deceased], Freedman BI, et al. The effect of ACACB cis-variants on gene expression and metabolic traits. PLoS ONE. 2011;6(8):e23860.

Sanchez E, Nadig A, Richardson BC, Freedman BI, Kaufman KM, Kelly JA, Niewold TB, Kamen DL, Ziegler JT, Langefeld CD, et al. Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus. Ann Rheum Dis. 2011;70(10):1752-1757.

Reeves-Daniel A, Bailey A, Assimos D, Westcott C, Adams PL, Hartmann EL, Rogers J, Farney AC, Stratta RJ, Daniel K, Freedman BI. Donor-recipient relationships in African American vs. Caucasian live kidney donors. Clin Transplant. 2011;25(5):E487-E490.

Reeves-Daniel AM, Divers J, Langefeld CD, Freedman BI. Response to mechanism of action of APOL1 in renal allograft survival (and native CKD) remains unclear [letter]. Am J Transplant. 2011;11(10):2260.

Tan W, Sunahori K, Zhao J, Deng Y, Langefeld CD, Williams AH, Comeau ME, Ziegler JT, Marion MC, Freedman BI, et al. Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups. Arthritis Rheum. 2011;63(9):2755-2763.

Kohzuma T, Yamamoto T, Uematsu Y, Shihabi ZK, Freedman BI. Basic performance of an enzymatic method for glycated albumin and reference range determination. J Diabetes Sci Technol. 2011;5(6):1455-1462.

Cox AJ, Wing MR, Carr JJ, Hightower RC, Smith SC, Xu J, Wagenknecht LE, Bowden DW, Freedman BI. Association of PNPLA3 SNP rs738409 with liver density in African Americans with type 2 diabetes mellitus. Diabetes Metab. 2011;37(5):452-455.

Murea M, Register TC, Divers J, Bowden DW, Carr JJ, Hightower RC, Smith SC, Hruska KA, Langefeld CD, Freedman BI. Relationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study [abstract]. J Am Soc Nephrol. 2011;22(Abstract Suppl):715A.

Freedman BI, Langefeld CD, Murea M, Ma L, Otvos JD, Turner J, Antinozzi PA, Rocco MV, Parks JS. Apolipoprotein L1 (APOL1) nephropathy risk variants associate with HDL subfraction concentration in African Americans [abstract]. J Am Soc Nephrol. 2011;22(Abstract Suppl):178A.

Freedman BI, Hicks PJ, Langefeld CD, Lu L, Bleyer AJ, Divers J, Nachman PH, Derebail VK, Bowden DW. Sickle cell trait is not associated with ESRD susceptibility in African Americans [abstract]. J Am Soc Nephrol. 2011;22(Abstract Suppl):463A.

Winkler CA, Freedman BI, Kao WHL, Langefeld CD, Astor BC, Nelson GW, Comeau ME, Bowden DW, Kopp JB, Lipkowitz MS. APOL1 risk genotypes are enriched in African American Study of Kidney Disease and Hypertension (AASK) participants, particularly among those with kidney disease progression [abstract]. J Am Soc Nephrol. 2011;22(Abstract Suppl):458A-459A.

Kopp JB, Freedman BI, Winkler CA, Nelson GW, Bowden DW, Comeau ME, Langefeld CD. APOL1 and MYH9 genetic variants are independently associated with kidney disease risk in African Americans [abstract]. J Am Soc Nephrol. 2011;22(Abstract Suppl):460A-461A.

Cox AJ, Lehtinen AB, Xu J, Langefeld CD, Freedman BI, Carr JJ, Bowden DW. Polymorphisms in the selenoprotein S gene are associated with quantitative measures of subclinical cardiovascular disease in the Diabetes Heart Study [abstract]. Diabetes. 2011;60(Suppl 1):A5.

Hugenschmidt C, Hayasaka S, Langefeld C, Freedman B, Carr JJ, Williamson J, Bowden DW. Cognitive performance is related to vascular disease and diabetes in a family study of type 2 diabetes [abstract]. Diabetes. 2011;60(Suppl 1):A225-A226.

Ramos PS, Oates JC, Kamen DL, Gaffney PM, Langefeld CD, Kelly JA, Kaufman KM, Kimberly RP, Niewold TB, Freedman BI, et al. Association of reactive intermediate genes with systemic lupus erythematosus (SLE) varies across populations with differnet African ancestries [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S250.

Adrianto I, Wiley GB, Wang S, Kaufman KM, Anaya J-M, Alarcon-Riquelme ME, Bae S-C, Brown EE, Freedman BI, Langefeld CD, et al. A functional haplotype in the region of TNIP1 is associated with systemic lupus erythematosus in multiple populations [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S248.

Wang S, Adrianto I, Wiley GB, Kaufman KM, Anaya J-M, Alarcon-Riquelme ME, Bae S-C, Brown EE, Freedman BI, Langefeld CD, et al. A single risk haplotype in the region of UBE2L3 is associated with systemic lupus erythematosus in multiple ethnic populations [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S247-S248.

Kariuki S, Franek BS, Kumar AA, Kumabe M, Kaufman KM, Anaya J-M, Alarcon-Riquelme ME, Bae S-C, Freedman BI, Langefeld CD, et al. Genetic associations with serologic autoimmunity in a large multi-ancestral systemic lupus erythematosus cohort [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S246.

Sanchez E, Nadig A, Richardson BC, Freedman BI, Kaufman K, Niewold TB, Kamen DL, Gilkeson GS, Langefeld CD, Kimberly RP, et al. Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S245-S246.

Chung SA, Brown EE, Williams AH, Bhangale T, Ramos PS, Ziegler JT, Freedman BI, Kimberly RP, Vyse TJ, Langefeld CD, et al. Lupus nephritis susceptibility markers in PDGRFA-GSX2, SLC5A11, ID4, and HAS2-SNTB1 regions identified from a meta-analysis of genome wide association studies of women with systemic lupus erythematosus [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S967.

Agarwal S, Cox AJ, Herrington DM, Morgan T, Xu J, Freedman BI, Carr JJ, Bowden DW. Coronary artery calcium score and prediction of cardiovascular mortality in diabetes. Diabetes Heart Study [abstract]. In: Meeting Abstracts of the 71st Scientific Sessions; 2011 June 24-28; San Diego (CA). 2011;():2-LB.

Hester J, Li J, Hicks P, Langefeld C, Freedman B, Bowden D, Ng M. Implication of European-derived adiposity loci in African Americans [abstract]. In: Abstracts of the 61st Annual Meeting of the American Society of Human Genetics; 2011 Oct 11-15; Montreal (Canada). 2011;():.

Price A, Zaitlen N, Lindstrom S, Pasaniuc B, Cornelis M, Genovese G, Bowden D, Freedman B, Hicks P, Langefeld C, et al. Liability threshold modeling of covariates increases power in case-control association studies [abstract]. In: Abstracts of the 61st Annual Meeting of the American Society of Human Genetics; 2011 Oct 11-15; Montreal (Canada). 2011;():.

Adams JN, Cox AJ, Freedman BI, Carr JJ, Bowden DW. Effects of variation in the haptoglobin gene on subclinical cardiovascular disease in the Diabetes Heart Study [abstract]. In: Abstracts of the 61st Annual Meeting of the American Society of Human Genetics; 2011 Oct 11-15; Montreal (Canada). 2011;():.

Oates J, Kamen D, Gaffney P, Langefeld C, Kelly J, Kaufman K, Kimberly R, Niewold T, Freedman B, Ramos P, et al. Genetic risk factors associated with systemic lupus erythematosus (SLE) in reactive intermediate genes vary across African ancestries [abstract]. In: Abstracts of the 61st Annual Meeting of the American Society of Human Genetics; 2011 Oct 11-15; Montreal (Canada). 2011;():.

Ng MCY, Sajuthi S, Cupples A, Divers J, Dupuis J, Fornage M, Kao L, Larkin E, Freedman B, Bowden DW, et al. Genetic ancestry and population structure of geographically separated African American populations [abstract]. In: Abstracts of the 61st Annual Meeting of the American Society of Human Genetics; 2011 Oct 11-15; Montreal (Canada). 2011;():.

Hellwege JN, Hicks PJ, Palmer ND, Freedman BI, Bowden DW. Examination of rare variants in HNF4 alpha in European Americans with type 2 diabetes [abstract]. In: Abstracts of the 61st Annual Meeting of the American Society of Human Genetics; 2011 Oct 11-15; Montreal (Canada). 2011;():.

Cooke J, Ng M, Lu L, Li J, An S, Hester J, Xu J, Freedman B, Langefeld C, Bowden D, Palmer N. Genetic risk assessment of type 2 diabetes associated polymorphisms in African-Americans [abstract]. In: Abstracts of the 61st Annual Meeting of the American Society of Human Genetics; 2011 Oct 11-15; Montreal (Canada). 2011;():.

Freedman BI, Bowden DW. Risk factors: race, renal disease and albuminuria [editorial]. Nat Rev Nephrol. 2011;7(12):679-680.

Freedman BI, Langefeld CD, Murea M, Ma L, Otvos JD, Turner J, Antinozzi PA, Divers J, Hicks PJ, Bowden DW, Rocco MV, Parks JS. Apolipoprotein L1 nephropathy risk variants associate with HDL subfraction concentration in African Americans. Nephrol Dial Transplant. 2011;26(11):3805-3810.

Hicks PJ, Langefeld CD, Lu L, Bleyer AJ, Divers J, Nachman PH, Derebail VK, Bowden DW, Freedman BI. Sickle cell trait is not independently associated with susceptibility to end-stage renal disease in African Americans. Kidney Int. 2011;80(12):1339-1343.

Sanchez E, Comeau ME, Freedman BI, Kelly JA, Kaufman K, Langefeld CD, Brown EE, Merrill JT, Tsao BP, Kamen DL, et al. Identification of novel genetic susceptibility loci in African-American lupus patients using a candidate gene association study [abstract]. Arthritis Rheum. 2011;63(10 Suppl):S965-S966.

Sanchez E, Comeau ME, Freedman BI, Kelly JA, Kaufman KM, Langefeld CD, Brown EE, Alarcon GS, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Vila LM, Merrill JT, Tsao BP, Kamen DL, Gilkeson GS, James JA, Vyse TJ, Gaffney PM,. Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study. Arthritis Rheum. 2011;63(11):3493-3501.

Rudock ME, Cox AJ, Ziegler JT, Lehtinen AB, Connelly JJ, Freedman BI, Carr JJ, Langefeld CD, Hauser ER, Horne BD, Bowden DW. Cigarette smoking status has a modifying effect on the association between polymorphisms in KALRN and measures of cardiovascular risk in the Diabetes Heart Study. Genes Genomics. 2011;33(5):483-490.

Agarwal S, Herrington DM, Cox AJ, Morgan TM, Xu J, Carr JJ, Freedman BI, Bowden DW. The association of vascular calcification and all cause mortality in diabetes: Diabetes Heart Study [abstract]. Circulation. 2011;124(21 Suppl):A8165.

Divers J, Wagenknecht LE, Bowden DW, Carr JJ, Hightower RC, Xu J, Langefeld CD, Freedman BI. Ethnic differences in the relationship between albuminuria and calcified atherosclerotic plaque: the African American-Diabetes Heart Study. Diabetes Care. 2010;33(1):131-138.


Divers J, Freedman BI. Susceptibility genes in common complex kidney disease. Curr Opin Nephrol Hypertens. 2010;19(1):79-84.

Freedman BI, Shenoy RN, Planer JA, Clay KD, Shihabi ZK, Burkart JM, Sabio H, Byers JR, Russell GB, Bleyer AJ, et al. Comparison of glycated albumin and hemoglobin A1c concentrations in diabetic subjects on peritoneal and hemodialysis. Perit Dial Int. 2010;30(1):72-79.

Leak TS, Langefeld CD, Keene KL, Gallagher CJ, Lu L, Mychaleckyj JC, Rich SS, Freedman BI, Bowden DW, Sale MM. Chromosome 7p linkage and association study for diabetes related traits and type 2 diabetes in an African-American population enriched for nephropathy. BMC Med Genet. 2010;11(1):article 22.

Maeda S, Kobayashi M-a, Araki S-i, Babazono T, Freedman BI, Bostrom MA, Cooke JN, Toyada M, Umezono T, Tarnow L, et al. A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes. PLoS Genet. 2010;6(2):e1000842.

Freedman BI, Shihabi ZK, Andries L, Cardona CY, Peacock TP, Byers JR, Russell GB, Stratta RJ, Bleyer AJ. Relationship between assays of glycemia in diabetic subjects with advanced chronic kidney disease. Am J Nephrol. 2010;31(5):375-379.

Freedman BI, Parekh RS, Kao WH. Genetic basis of nondiabetic end-stage renal disease. Semin Neurol. 2010;30(2):101-110.

Freedman BI, Wagenknecht LE, Hairston KG, Bowden DW, Carr JJ, Hightower RC, Gordon EJ, Xu J, Langefeld CD, Divers J. Vitamin D, adiposity, and calcified atherosclerotic plaque in African-Americans. J Clin Endocrinol Metab. 2010;95(3):1076-1083.

Nelson GW, Freedman BI, Bowden DW, Langefeld CD, An P, Hicks PJ, Bostrom MA, Johnson RC, Kopp JB, Winkler CA. Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15. Hum Mol Genet. 2010;19(9):1805-1815.

Freedman BI, Shihabi ZK. Variation in urinary myoinositol in renal disorders [abstract]. Ann Clin Lab Sci. 2010;40(2):201.

Chen Y, Lipkowitz MS, Salem RM, Fung MM, Bhatnagar V, Mahata M, Nievergelt CM, Hicks PJ, Bowden DW, Freedman BI, et al. Progression of chronic kidney disease: adrenergic genetic influence on glomerular filtration rate decline in hypertensive nephrosclerosis. Am J Nephrol. 2010;32(1):23-30.

Buckalew VM, Freedman BI. Reappraisal of the impact of race on survival in patients on dialysis. Am J Kidney Dis. 2010;55(6):1102-1110.

Murea M, Freedman BI. Essential hypertension and risk of nephropathy: a reappraisal. Curr Opin Nephrol Hypertens. 2010;19(3):235-241.

Burdon KP, Rudock ME, Lehtinen AB, Langefeld CD, Bowden DW, Register TC, Liu Y, Freedman BI, Carr JJ, Hedrick CC, et al. Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the Diabetes Heart Study. Mediators Inflamm. 2010;2010():170153.

Sedor JR, Freedman BI. Genetics and the kidney: promise, potential, and challenges introduction [editorial]. Semin Nephrol. 2010;30(2):99-100.

Bleyer AJ, Reddy SV, Sujata L, Russell GB, Akinnifesi D, Bleyer AJ Jr, Hire D, Shihabi Z, Knovich MA, Daeihagh P, Calles J, Freedman BI. Sickle cell trait and development of microvascular complications in diabetes mellitus. Clin J Am Soc Nephrol. 2010;5(6):1015-1020.

Reeves-Daniel AM, Iskandar SS, Bowden DW, Bostrom MA, Hicks PJ, Comeau ME, Langefeld CD, Freedman BI. Is collapsing C1q nephropathy another MYH9-associated kidney disease? A case report. Am J Kidney Dis. 2010;55(5):e21-e24.

Bostrom MA, Freedman BI. The spectrum of MYH9-associated nephropathy. Clin J Am Soc Nephrol. 2010;5(6):1107-1113.

Freedman BI, Edberg JC, Comeau ME, Murea M, Bowden DW, Divers J, Alarcon GS, Brown EE, McGwin G Jr, Langefeld CD, et al. The non-muscle myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African Americans. Am J Nephrol. 2010;32(1):66-72.


Bostrom MA, Lu L, Chou J, Hicks PJ, Xu J, Langefeld CD, Bowden DW, Freedman BI. Candidate genes for non-diabetic ESRD in African Americans: a genome-wide association study using pooled DNA. Hum Genet. 2010;128(2):195-204.

Genovese G, Friedman DJ, Ross MD, Lecordier L, Uzureau P, Freedman BI, Bowden DW, Langefeld CD, Oleksyk TK, Hicks PJ, et al. Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science. 2010;329(5993):841-845.

Lewis JP, Palmer ND, Ellington JB, Divers J, Ng MCY, Lu L, Langefeld CD, Freedman BI, Bowden DW. Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans. Genomics. 2010;96(4):211-219.

Bleyer AJ, Vidya S, Sujata L, Russell GB, Akinnifesi D, Hire D, Shihabi Z, Knovich MA, Daeihagh P, Calles J, Freedman BI. The impact of sickle cell trait on glycated haemoglobin in diabetes mellitus. Diabet Med. 2010;27(9):1012-1016.

Bostrom MA, Hicks PJ, Lu L, Langefeld CD, Freedman BI, Bowden DW. Association of polymorphisms in the klotho gene with severity of non-diabetic ESRD in African Americans. Nephrol Dial Transplant. 2010;25(10):3348-3355.

Divers J, Wagenknecht LE, Bowden DW, Carr JJ, Hightower RC, Ding J, Xu J, Langefeld CD, Freedman BI. Regional adipose tissue associations with calcified atherosclerotic plaque: African American-Diabetes Heart Study. Obesity (Silver Spring). 2010;18(10):2004-2009.

Freedman BI, Kopp JB, Langefeld CD, Genovese G, Friedman DJ, Nelson GW, Winkler CA, Bowden DW, Pollak MR. The apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans. J Am Soc Nephrol. 2010;21(9):1422-1426.

Murea M, Freedman BI, Parks JS, Antinozzi PA, Elbein SC [deceased], Ma L. Lipotoxicity in diabetic nephropathy: the potential role of fatty acid oxidation. Clin J Am Soc Nephrol. 2010;5(12):2373-2379.

Reeves-Daniel A, Freedman BI, Assimos D, Hartmann EL, Bleyer A, Adams PL, Westcott C, Stratta RJ, Rogers J, Farney AC, Daniel KR. Short-term renal outcomes in African American and Caucasian donors following live kidney donation. Clin Transplant. 2010;24(5):717-722.

Tang SCW, Leung VTM, Chan LYY, Ma L, Elbein SC [deceased], Bowden DW, Hicks PJ, Comeau ME, Langefeld CD, Freedman BI, et al. The acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes. Nephrol Dial Transplant. 2010;25(12):3931-3934.

Divers J, Wagenknecht LE, Bowden DW, Carr JJ, Hightower RC, Register TC, Xu J, Langefeld CD, Freedman BI. Ethnic differences in the relationship between pericardial adipose tissue and coronary artery calcified plaque: African-American-diabetes heart study. J Clin Endocrinol Metab. 2010;95(12):5382-5389.

Freedman BI, Sedor JR. Intensive blood-pressure control in hypertensive chronic kidney disease [letter]. N Engl J Med. 2010;363(26):2565.

Bowden DW, Cox AJ, Freedman BI, Hugenschimdt CE [sic] [Hugenschmidt CE], Wagenknecht LE, Herrington D, Agarwal S, Register TC, Maldjian JA, Ng MC-Y, Hsu F-C, Langefeld CD, Williamson JD, Carr JJ. Review of the Diabetes Heart Study (DHS) family of studies: a comprehensively examined sample for genetic and epidemiological studies of type 2 diabetes and its complications. Rev Diabet Stud. 2010;7(3):188-201.

Mcdonough CW, Allred ND, Hicks PJ, Bostrom MA, Lu L, Ng M, Divers J, Langefeld CD, Freedman BI, Bowden DW. A genome wide association study for diabetic nephropathy genes in African Americans [abstract]. J Am Soc Nephrol. 2010;21(Suppl):729A.

Freedman BI, Langefeld CD, Lu L, Divers J, Comeau ME, Allred ND, Hicks PJ, Bostrom MA, Cooke JN, Mcdonough CW, Bowden DW, et al. Accounting for risk variants in MYH9 reveals FRMD3 association with diabetic ESRD in African Americans [abstract]. J Am Soc Nephrol. 2010;21(Suppl):728A.

Antinozzi PA, Barnes BC, Deegan D, Ma L, Freedman BI, Murea M. Digital deconstruction of heterogeneous renal cell preparations with high-content imaging and cell specific biomarkers [abstract]. J Am Soc Nephrol. 2010;21(Suppl):409A.

Bostrom MA, Lu L, Chou JW, Hicks PJ, Xu J, Langefeld CD, Bowden DW, Freedman BI. Non-diabetic end-stage renal disease (ESRD) in African Americans: candidate genes from analysis of a pooled DNA-based genome wide association study (GWAS) [abstract]. J Am Soc Nephrol. 2010;21(Suppl):89A.

Bostrom MA, Hicks PJ, Lu L, Ng M, Langefeld CD, Freedman BI, Bowden DW. Sequencing of alpha-actinin-4 to identify variants associated with non-diabetic end-stage renal disease (ESRD) in African Americans [abstract]. J Am Soc Nephrol. 2010;21(Suppl):729A.

Murea M, Lu L, Hicks PJ, Bowden DW, Divers J, Langefeld CD, Freedman BI. Genetic variants identified by GWAS suggest intracellular calcium, vascular remodeling, and cardiac repolarization pathways impact dialytic survival in African Americans with diabetes [abstract]. J Am Soc Nephrol. 2010;21(Suppl):730A.

Cooke JN, Bostrom MA, Hicks PJ, Ng M, Comeau ME, Divers J, Langefeld CD, Freedman BI, Bowden DW. Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans [abstract]. J Am Soc Nephrol. 2010;21(Suppl):731A.

Agarwal S, Morgan T, Herrington D, Xu J, Freedman BI, Carr JJ, Bowden DW. Risk stratification in a diabetic population with metabolic syndrome using coronary calcium scores: Diabetes Heart Study [abstract]. Circulation. 2010;122(21 Suppl):abstr 9342.

Lehtinen AB, Daniel KR, Shah SA, Nelson MR, Ziegler JT, Freedman BI, Carr JJ, Herrington DM, Langefeld CD, Bowden DW. Relationship between genetic variants in myocardial sodium and potassium channel genes and QT interval duration in diabetics: the Diabetes Heart Study. Ann Noninvasive Electrocardiol. 2009;14(1):72-79.

Hawfield A, Freedman BI. Pre-eclampsia: the pivotal role of the placenta in its pathophysiology and markers for early detection. Ther Adv Cardiovasc Dis. 2009;3(1):65-73.

Freedman BI, Kopp JB, Winkler CA, Nelson GW, Rao DC, Eckfeldt JH, Leppert MF, Hicks PJ, Divers J, Langefeld CD, Hunt SC. Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with albuminuria in hypertensive African Americans: the HyperGEN study. Am J Nephrol. 2009;29(6):626-632.

Bleyer AJ, Hire D, Russell GB, Xu J, Divers J, Shihabi Z, Bowden DW, Freedman BI. Ethnic variation in the correlation between random serum glucose concentration and glycated haemoglobin. Diabet Med. 2009;26(2):128-133.

McClellan WM, Satko SG, Gladstone E, Krisher JO, Narva AS, Freedman BI. Individuals with a family history of ESRD are a high-risk population for CKD: implications for targeted surveillance and intervention activities. Am J Kidney Dis. 2009;53(3 Suppl 3):S100-S106.

Freedman BI, Hicks PJ, Bostrom MA, Cunningham ME, Liu Y, Divers J, Kopp JB, Winkler CA, Langefeld CD, Bowden DW, et al. Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans. Kidney Int. 2009;75(7):736-745.

Leak TS, Perlegas PS, Smith SG, Keene KL, Hicks PJ, Langefeld CD, Mychaleckyj JC, Kirk JK, Freedman BI, Bowden DW, Sale MM, et al. Variants in intron 13 of the ELMO1 gene are associated with diabetic nephropathy in African Americans. Ann Hum Genet. 2009;73(2):152-159.

Young TA, Patel TS, Camacho F, Clark A, Freedman BI, Kaur M, Fountain J, Williams LL, Yosipovitch G, Fleischer AB Jr. A pramoxine-based anti-itch lotion is more effective than a control lotion for the treatment of uremic pruritus in adult hemodialysis patients. J Dermatolog Treat. 2009;20(2):76-81.

Bostrom MA, Freedman BI, Langefeld CD, Liu L, Hicks PJ, Bowden DW. Association of adiponectin gene polymorphisms with type 2 diabetes in an African American population enriched for nephropathy. Diabetes. 2009;58(2):499-504.

Friedman DJ, Talbert ME, Bowden DW, Freedman BI, Mukanya Y, Enjyoji K, Robson SC. Functional ENTPD1 polymorphisms in African Americans with diabetes and end-stage renal disease. Diabetes. 2009;58(4):999-1006.

Rudock ME, Liu Y, Ziegler JT, Allen SG, Lehtinen AB, Freedman BI, Carr JJ, Langefeld CD, Bowden DW. Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study. Atherosclerosis. 2009;203(2):459-465.

Moossavi S, Freedman BI. Treating anemia with erythropoiesis-stimulating agents: effects on quality of life [editorial]. Arch Intern Med. 2009;169(12):1100-1101.

Freedman BI, Bowden DW, Rich SS. Susceptibility to diabetic nephropathy In: Lifton RP, Somlo S, Giebisch GH, Seldin DW, eds. Genetic diseases of the kidney. Boston (MA): Elsevier/Academic Press;2009: 771-792.

Iyengar SK, Freedman BI. Chronic renal failure In: Lang F, ed. Encyclopedia of molecular mechanisms of disease. Berlin: Springer;2009: .

Shihabi ZK, Garrison KJ, Freedman BI. Determination of urinary myo-inositol using the Beckman DXC 800 [abstract]. Clin Chem. 2009;55(6 Suppl):A211.

McDonough CW, Hicks PJ, Lu L, Langefeld CD, Freedman BI, Bowden DW. The influence of carnosinase gene polymorphisms on diabetic nephropathy risk in African-Americans. Hum Genet. 2009;126(2):265-275.

Song E-Y, McClellan WM, McClellan A, Gadi R, Hadley AC, Krisher J, Clay M, Freedman BI. Effect of community characteristics on familial clustering of end-stage renal disease. Am J Nephrol. 2009;30(6):499-504.

Freedman BI, Nagaraj SK, Lin JJ, Gautreaux MD, Bowden DW, Iskandar SS, Stratta RJ, Rogers J, Hartmann EL, Farney AC, Reeves-Daniel AM. Potential donor-recipient MYH9 genotype interactions in posttransplant nephrotic syndrome after pediatric kidney transplantation. Am J Transplant. 2009;9(10):2435-2440.

Bowden DW, Allred NP, Ng MC, Langefeld CD, Freedman BI. Genome wide analysis of African American type 2 diabetes [abstract]. Diabetologia. 2009;52(Suppl 1):S37.

Freedman BI, Bowden DW, Ziegler JT, Langefeld CD, Lehtinen AB, Rudock ME, Lenchik L, Hruska KA, Register TC, Carr JJ. Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study. J Bone Miner Res. 2009;24(10):1719-1727.

Malhotra A, Igo RP Jr, Thameem F, Kao WHL, Abboud HE, Adler SG, Arar NH, Bowden DW, Duggirala R, Freedman BI, et al. Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations--significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes research group. Diabetes Metab Res Rev. 2009;25(8):740-747.

Freedman BI, Hicks PJ, Bostrom MA, Comeau ME, Divers J, Bleyer AJ, Kopp JB, Winkler CA, Langefeld CD, Bowden DW, et al. Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans with clinically diagnosed type 2 diabetes mellitus-associated ESRD. Nephrol Dial Transplant. 2009;24(11):3366-3371.

McDonough CW, Bostrom MA, Lu L, Hicks PJ, Langefeld CD, Divers J, Mychaleckyj JC, Freedman BI, Bowden DW. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. Hum Genet. 2009;126(6):805-817.

Bostrom MA, Lu L, Chou J, Hicks PJ, Xu J, Langefeld CD, Freedman BI, Bowden DW. Genome wide association study of non-diabetic end stage renal disease in African Americans using pooled DNA [abstract]. Presented at the 59th Annual Meeting of The American Society of Human Genetics, October 21, 2009, Honolulu, Hawaii. 2009;():A676.

Hester JM, Palmer ND, Ng MCY, Adeyemo A, Rotimi C, Freedman BI, Bowden DW. Comprehensive genetic evaluation of variation at the TCF7L2 locus in African Americans [abstract]. Diabetes. 2009;58(Suppl 1):A304.

Divers J, Wagenknecht LE, Bowden DW, Carr JJ, Hightower RC, Xu J, Langefeld CD, Freedman BI. Ethnic differences in the relationship between albuminuria and calcified atherosclerotic plaque: African American-Diabetes Heart Study [abstract]. J Am Soc Nephrol. 2009;20(Renal Week 2009 Abstract Issue):395A.

McDonough CW, Palmer ND, Bostrom MA, Hicks PJ, Lu L, Divers J, Langefeld CD, Freedman BI, Bowden DW. A genome-wide association study (GWAS) of diabetic nephropathy (DN) in African Americans (AA) [abstract]. J Am Soc Nephrol. 2009;20(Renal Week 2009 Abstract Issue):433A.

Freedman BI, Bostrom MA, Cooke JN, Divers J, Langefeld CD, Nelson RG, Kretzler M, Maeda S, Bowden DW. ACACB gene associations with type 2 diabetes-associated ESRD [abstract]. J Am Soc Nephrol. 2009;20(Renal Week 2009 Abstract Issue):55A.

Bostrom MA, Hicks PJ, Lu L, Langefeld CD, Bowden DW, Freedman BI. Association of polymorphisms in the Klotho gene with age at onset of non-diabetic ESRD in African Americans [abstract]. J Am Soc Nephrol. 2009;20(Renal Week 2009 Abstract Issue):431A.

Freedman BI, Hicks PJ, Bostrom MA, Comeau ME, Divers J, Bleyer AJ, Kopp JB, Winkler CA, Langefeld CD, Bowden DW, et al. Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans (AA) with type 2 diabetes (T2DM)-associated ESRD [abstract]. J Am Soc Nephrol. 2009;20(Renal Week 2009 Abstract Issue):431A.

Lipkowitz MS, Iyengar SK, Molineros J, Langefeld CD, Comeau ME, Klotman PE, Bowden DW, Freedman RG, Khitrov G, Freedman BI, et al. Association analysis of the non-muscle myosin heavy chain 9 gene (MYH9) in hypertensive nephropathy: results from the African American Study of Kidney Disease and Hypertension (AASK) [abstract]. J Am Soc Nephrol. 2009;20(Renal Week 2009 Abstract Issue):56A.

Freedman BI, Shihabi ZK, Andries L, Spainhour M, Byers JR, Russell GB, Stratta RJ, Calles J, Bleyer AJ. Accuracy of the glycated albumin (GA) and hemoglobin (Hb) A1c assays in diabetic subjects with advanced chronic kidney disease (CKD) [abstract]. J Am Soc Nephrol. 2009;20(Renal Week 2009 Abstract Issue):424A.

Bostrom MA, Lu L, Chou J, Hicks PJ, Xu J, Langefeld CD, Bowden DW, Freedman BI. Candidate genes for non-diabetic end stage renal disease in African Americans identified by genome-wide association [abstract]. J Am Soc Nephrol. 2009;20(Renal Week 2009 Abstract Issue):431A.

Winkler C, Nelson GW, Freedman BI, Bowden DW, Langefeld CD, Kopp JB. MYH9 fine mapping refines region of association with chronic and end stage kidney diseases to introns 12 and 13 [abstract]. J Am Soc Nephrol. 2009;20(Renal Week 2009 Abstract Issue):431A.

Carr JJ, Register TC, Hsu F-C, Lohman K, Lenchik L, Bowden DW, Langefeld CD, Xu J, Wagenknecht LE, Freedman BI, et al. Calcified atherosclerotic plaque and bone mineral density in type 2 diabetes: the Diabetes Heart Study. Bone. 2008;42(1):43-52.

Saran AM, Hsu F-C, Lohman KK, Carr JJ, Bowden DW, Wagenknecht LE, Freedman BI. Kidney volume associations with subclinical renal and cardiovascular disease: the Diabetes Heart Study. Am J Nephrol. 2008;28(3):366-371.

Bleyer AJ, Sedor JR, Freedman BI, O'Brien A, Russell GB, Graley J, Schelling JR. Risk factors for development and progression of diabetic kidney disease and treatment patterns among diabetic siblings of patients with diabetic kidney disease. Am J Kidney Dis. 2008;51(1):29-37.

Schelling JR, Abboud HE, Nicholas SB, Pahl MV, Sedor JR, Adler SG, Arar NH, Bowden DW, Freedman BI, Rich SS, et al. Genome-wide scan for estimated glomerular filtration rate in multi-ethnic diabetic populations: the Family Investigatin of Nephropathy and Diabetes (FIND). Diabetes. 2008;57(1):235-243.

Yosipovitch G, Patel TS, Freedman BI. A common cause of pruritus in dialysis patients [reply to letter]. Am J Kidney Dis. 2008;51(2):345-346.

Moossavi S, Tuttle AB, Vachharajani TJ, Plonk G, Bettmann MA, Majekodunmi O, Russell BG, Regan JD, Freedman BI. Long-term outcomes of transposed basilic vein arteriovenous fistulae. Hemodial Int. 2008;12(1):80-84.

Freedman BI, Bowden DW, Rich SS, Xu J, Wagenknecht LE, Ziegler J, Hicks PJ, Langefeld CD. Genome-wide linkage scans for renal function and albuminuria in type 2 diabetes mellitus: the Diabetes Heart Study. Diabet Med. 2008;25(3):268-276.

Nelson MR, Daniel KR, Carr JJ, Freedman BI, Prineas RJ, Bowden DW, Herrington DM. Associations between electrocardiographic interval durations and coronary artery calcium scores: the Diabetes Heart Study. Pacing Clin Electrophysiol. 2008;31(3):314-321.

Salem RM, Cadman PE, Chen Y, Rao F, Wen G, Hamilton BA, Rana BK, Bowden DW, Hicks PJ, Freedman BI, et al. Chromogranin A polymorphisms are associated with hypertensive renal disease. J Am Soc Nephrol. 2008;19(3):600-614.

Keene KL, Mychaleckyj JC, Smith SG, Leak TS, Perlegas PS, Langefeld CD, Freedman BI, Rich SS, Bowden DW, Sale MM. Association of the distal region of the ectonucleotide pyrophosphatase/phosphodiesterase 1 gene with type 2 diabetes in an African-American population enriched for nephropathy. Diabetes. 2008;57(4):1057-1062.

Horton GD, Freedman BI, Shihabi ZK. Glycated albumin analysis on an automated analyzer [abstract]. Ann Clin Lab Sci. 2008;38(2):188.

Lehtinen AB, Newton-Cheh C, Ziegler JT, Langefeld CD, Freedman BI, Daniel KR, Herrington DM, Bowden DW. Association of NOS1AP genetic variants with QT interval duration in families from the Diabetes Heart Study. Diabetes. 2008;57(4):1108-1114.

Vachharajani TJ, Moossavi S, Daeihgah P, Jordan JR, Coe MS, Burkart JM, Freedman B. Academic free-standing vascular access centers: early experience [abstract]. Semin Dial. 2008;21(1):106.

Vachharajani TJ, Moossavi S, Kaufman TM, Jordan JR, Freedman BI, Burkart JM. Re-evaluating the fistula first initiative in octogenarian dialysis patients [abstract]. J Vasc Access. 2008;9(Suppl 1):S16-S17.

Keene KL, Mychaleckyj JC, Smith SG, Leak TS, Perlegas PS, Langefeld CD, Herrington DM, Freedman BI, Bowden DW, Sale MM, et al. Comprehensive evaluation of the estrogen receptor alpha gene reveals further evidence for association with type 2 diabetes enriched for nephropathy in an African American population. Hum Genet. 2008;123(4):333-341.

Peacock TP, Shihabi ZK, Bleyer AJ, Dolbare EL, Byers JR, Knovich MA, Calles-Escandon J, Russell GB, Freedman BI. Comparison of glycated albumin and hemoglobin A1C levels in diabetic subjects on hemodialysis. Kidney Int. 2008;73(9):1062-1068.

Burdon KP, Lehtinen AB, Langefeld CD, Carr JJ, Rich SS, Freedman BI, Herrington D, Bowden DW. Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular disease in the Diabetes Heart Study. Diab Vasc Dis Res. 2008;5(2):128-134.

Hicks PJ, Staten JL, Palmer ND, Langefeld CD, Ziegler JT, Keene KL, Sale MM, Bowden DW, Freedman BI. Association analysis of the ephrin-B2 gene in African-Americans with end-stage renal disease. Am J Nephrol. 2008;28(6):914-920.

Reeves-Daniel A, Daniel K, Assimos D, Westcott C, Rogers J, Farney A, Stratta R, Hartmann E, Adams P, Bleyer A, Freedman B. Similar short-term renal outcomes among African Americans and caucasians following live kidney donation [abstract]. Am J Transplant. 2008;8(Suppl 2):191.

Shihabi ZK, Horton GD, Freedman BI. Glycated albumin analysis on the ADVIA 1650 [abstract]. Clin Chem. 2008;54(6 Suppl):A173.

Divers J, Moossavi S, Langefeld CD, Freedman BI. Genetic admixture: a tool to identify diabetic nephropathy genes in African Americans. Ethn Dis. 2008;18(3):384-388.

Leak TS, Mychaleckyj JC, Smith SG, Keene KL, Gordon CJ, Hicks PJ, Freedman BI, Bowden DW, Sale MM. Evaluation of a SNP map of 6q24-27 confirms diabetic nephropathy loci and identifies novel associations in type 2 diabetes patients with nephropathy from an African-American population. Hum Genet. 2008;124(1):63-71.

Liu Y, Freedman BI, Burdon KP, Langefeld CD, Howard T, Herrington D, Goff DC Jr, Bowden DW, Wagenknecht LE, Rich SS, et al. Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes. Am J Kidney Dis. 2008;52(2):242-250.

Keene KL, Mychaleckyj JC, Leak TS, Smith SG, Perlegas PS, Divers J, Langefeld CD, Freedman BI, Bowden DW, Sale MM. Exploration of the utility of ancestry informative markers for genetic association studies of African Americans with type 2 diabetes and end stage renal disease. Hum Genet. 2008;124(2):147-154.

Lewis JP, Palmer ND, Hicks PJ, Sale MM, Langefeld CD, Freedman BI, Divers J, Bowden DW. Association analysis in African Americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies. Diabetes. 2008;57(8):2220-2225.

Zhang D, Freedman BI, Flekac M, Santos E, Hicks PJ, Bowden DW, Efendic S, Brismar K, Gu HF. Evaluation of genetic association and expression reduction of TRPC1 in the development of diabetic nephropathy. Am J Nephrol. 2008;29(3):244-251.

Kao WH, Klag MJ, Meoni LA, Reich D, Berthier-Schaad Y, Li M, Coresh J, Patterson N, Divers J, Freedman BI, et al. MYH9 is associated with nondiabetic end-stage renal disease in African Americans. Nat Genet. 2008;40(10):1185-1192.

Kopp JB, Smith MW, Nelson GW, Johnson RC, Freedman BI, Bowden DW, Oleksyk T, Mckenzie LM, Kajiyama H, Ahuja TS, et al. MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis. Nat Genet. 2008;40(10):1175-1184.

Arar NH, Freedman BI, Adler SG, Iyengar SK, Chew EY, Davis MD, Satko SG, Bowden DW, Duggirala R, Elston RC, et al. Heritability of the severity of diabetic retinopathy: the FIND-Eye study. Invest Ophthalmol Vis Sci. 2008;49(9):3839-3845.

Bowden DW, Lewis JP, Allred ND, Langefeld CD, Divers J, Freedman BI. Genetic analysis of 'European' type 2 diabetes SNPs from whole genome association studies in African Americans [abstract]. Diabetologia. 2008;51(Suppl 1):S129.

Bowden DW, Lehtinen AB, Ziegler JT, Rudock ME, Xu J, Wagenknecht LE, Herrington DM, Rich SS, Freedman BI, Carr JJ, Langefeld CD. Genetic epidemiology of subclinical cardiovascular disease in the Diabetes Heart Study. Ann Hum Genet. 2008;72(Pt 5):598-610.

Freedman BI, Shenoy RN, Planer JA, Bleyer AJ, Cardona CY, Peacock TP, Andreis L, Byers JR, Russell GB, Shihabi ZK, et al. Glycated albumin more accurately reflects glycaemic control than HbA(1c) in diabetic subjects on peritoneal and hemodialysis [abstract]. Diabetologia. 2008;51(Suppl 1):S413-S414.

Freedman BI, Sedor JR. Hypertension-associated kidney disease: perhaps no more [commentary]. J Am Soc Nephrol. 2008;19(11):2047-2051.

Bento JL, Palmer ND, Zhong M, Roh B, Lewis JP, Wing MR, Pandya H, Freedman BI, Langefeld CD, Bowden DW, et al. Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1. Genomics. 2008;92(4):226-234.

McKimmie RL, Daniel KR, Carr JJ, Bowden DW, Freedman BI, Register TC, Hsu F-C, Lohman KK, Weinberg RB, Wagenknecht LE. Hepatic steatosis and subclinical cardiovascular disease in a cohort enriched for type 2 diabetes: the Diabetes Heart Study. Am J Gastroenterol. 2008;103(12):3029-3035.

Kopp J, Smith M, Nelson G, Johnson R, Freedman B, Bowden D, Oleksyk T, McKenzie L, Kajiyama H, Ahuja T, et al. Genome wide admixture mapping identifies MYH9 as a major effect risk gene for focal segmental glomerulosclerosis and hypertensive end-stage kidney disease [abstract]. J Am Soc Nephrol. 2008;19():57A-58A.

Kao L, Klag M, Meoni L, Reich D, Berthier-Schaad Y, Li M, Coresh J, Patterson N, Divers J, Freedman B, et al. Admixture scan identifies MYH9 locus to be associated with non-diabetic ESRD in African Americans [abstract]. J Am Soc Nephrol. 2008;19():58A.

Freedman BI, Hicks PJ, Bostrom MA, Divers J, Winkler CA, Kopp JB, Nelson GW, Cunningham ME, Langefeld CD, Bowden DW. Non-muscle myosin heavy chain 9 (MYH9) gene associations in African Americans (AA) with non-diabetic ESRD [abstract]. J Am Soc Nephrol. 2008;19():132A.

McDonough CW, Hicks PJ, Freedman BI, Bowden DW. Association of the carnosinase genes (CNDP1 and CNDP2) with diabetic nephropathy (DN) in African Americans (AA) [abstract]. J Am Soc Nephrol. 2008;19():132A.

Freedman BI, Edberg C, Kopp JB, Winkler CA, Nelson GW, Alarcon GS, Brown EE, Divers J, Cunningham ME, Langefeld CD, et al. Association analysis of the non-muscle myosin heavy chain 9 (MYH9) gene in African Americans with lupus nephritis (LN) [abstract]. J Am Soc Nephrol. 2008;19():134A.

Freedman BI, Kopp JB, Winkler CA, Nelson GW, Rao DC, Eckfeldt JH, Leppert MF, Hunt SC. MYH9 variants are associated with albuminuria in HyperGEN families [abstract]. J Am Soc Nephrol. 2008;19():135A.

Thomas RL, Bleyer A, Kretzler M, Freedman BI, Iyengar SK, Schelling JR, Sedor JR. African American and European American diabetic sibs with normal GFR and family history of diabetic nephropathy (DN) lose GFR at equivalent rates but faster than diabetic subjects with no family history [abstract]. J Am Soc Nephrol. 2008;19():335A-336A.

Song EY, McClellan WM, McClellan A, Gadi R, Krisher J, Clay M, Freedman BI. The effect of neighborhood characteristics on family history (FH) of ESRD [abstract]. J Am Soc Nephrol. 2008;19():499A-500A.

Louvar D, Li N, Eckfeldt J, Gu C, Freedman B, Pankow J. Angiotensinogen as a candidate gene for albuminuria, glomerular filtration rate, and systolic blood pressure [abstract]. J Am Soc Nephrol. 2008;19():826A.

Moossavi S, Russell G, Vachharajani T, Burkart J, Freedman B. Effect of practice pattern on hemodialysis access thrombosis: the impact of access surveillance [abstract]. J Am Soc Nephrol. 2008;19():901A.

Planer JA, Bleyer AJ, Shenoy RN, Clay KD, Cardona CY, Sabio H, Russell GB, Shihabi ZK, Freedman BI. Ethnic variation in hemoglobin (Hb) A1c and glycated albumin (GA) assays in patients on hemodialysis (HD) [abstract]. J Am Soc Nephrol. 2008;19():974A.

Shenoy RN, Planer JA, Clay KD, Bleyer AJ, Burkart JM, Cardona CY, Byers JR, Russell GB, Shihabi ZK, Freedman BI, et al. Evaluation of glycated albumin (GA), HbA1c and serum glucose concentrations in diabetic peritoneal (PD) and hemodialysis (HD) patients [abstract]. J Am Soc Nephrol. 2008;19():974A-975A.

North KE, Franceschini N, Borecki IB, Gu CC, Heiss G, Province MA, Arnett DK, Lewis CE, Miller MB, Freedman BI, et al. Genotype-by-sex interaction on fasting insulin concentration: the HyperGEN Study. Diabetes. 2007;56(1):137-142.

Lehtinen AB, Burdon KP, Lewis JP, Langefeld CD, Ziegler JT, Rich SS, Register TC, Carr JJ, Freedman BI, Bowden DW. Association of alpha2-Heremans-Schmid glycoprotein polymorphisms with subclinical atherosclerosis. J Clin Endocrinol Metab. 2007;92(1):345-352.

Leon JM, Freedman BI, Miller MB, North KE, Hunt SC, Eckfeldt JH, Lewis CE, Kraja AT, Djousse L, Arnett DK. Genome scan of glomerular filtration rate and albuminuria: the HyperGEN study. Nephrol Dial Transplant. 2007;22(3):763-771.

Gallagher CJ, Keene KL, Mychaleckyj JC, Langefeld CD, Hirschhorn JN, Gordon CJ, Freedman BI, Rich SS, Bowden DW, Sale MM, et al. Investigation of the estrogen receptor-alpha gene with type 2 diabetes and/or nephropathy in African-American and European-American populations. Diabetes. 2007;56(3):675-684.

Freedman BI, Hicks PJ, Sale MM, Pierson ED, Langefeld CD, Rich SS, Xu J, McDonough C, Janssen B, Bowden DW, et al. A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic end-stage renal disease in European Americans. Nephrol Dial Transplant. 2007;22(4):1131-1135.

North KE, Chung J, Baird L, Avery C, Freedman BI, Kraja AT, Arnett D, Miller MB, Pankow JS, et al. Evidence for association between CHEK2 variants and type 2 diabetes: the HyperGEN study [abstract]. Circulation. 2007;115(8):e293-e294.

Yosipovitch G, Hicks MI, Freedman BI, Guzman-Sanchez DA, Ishiuji Y, Patel T, Chan YH, Crumrine D, Elias PM. The structure of the skin barrier and its relationship to pruritus in end-stage renal disease [abstract]. J Invest Dermatol. 2007;127(Suppl 1):S72.

Iyengar SK, Freedman BI, Sedor JR. Mining the genome for susceptibility to diabetic nephropathy: the role of large-scale studies and consortia. Semin Nephrol. 2007;27(2):208-222.

Freedman BI, DuBose TD Jr. Chronic kidney disease: cause and consequence of cardiovascular disease [editorial]. Arch Intern Med. 2007;167(11):1113-1115.

Satko SG, Sedor JR, Iyengar SK, Freedman BI. Familial clustering of chronic kidney disease. Semin Dial. 2007;20(3):229-236.

Iyengar SK, Abboud HE, Goddard KAB, Saad MF, Adler SG, Arar NH, Bowden DW, Duggirala R, Rich SS, Freedman BI, et al. Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: the Family Investigation of Nephropathy and Diabetes (FIND). Diabetes. 2007;56(6):1577-1585.

Hadley AC, Karchmer TB, Russell GB, McBride DG, Freedman BI. The prevalence of resistant bacterial colonization in chronic hemodialysis patients. Am J Nephrol. 2007;27(4):352-359.

Leak TS, Keene KL, Langefeld CD, Gallagher CJ, Mychaleckyj JC, Freedman BI, Bowden DW, Rich SS, Sale MM. Association of the proprotein convertase subtilisin/kexin-type 2 (PCSK2) gene with type 2 diabetes in an African American population. Mol Genet Metab. 2007;92(1-2):145-150.

Patel TS, Freedman BI, Yosipovitch G. An update on pruritus associated with CKD. Am J Kidney Dis. 2007;50(1):11-20.

Wagenknecht LE, Langefeld CD, Freedman BI, Carr JJ, Bowden DW. A comparison of risk factors for calcified atherosclerotic plaque in the coronary, carotid, and abdominal aortic arteries: the Diabetes Heart Study. Am J Epidemiol. 2007;166(3):340-347.

Shikany JM, Lewis CE, Freedman BI, Arnett DK, Leiendecker-Foster C, Jones TL, Redden DT, Oberman A. Plasma adiponectin concentrations and correlates in African Americans in the Hypertension Genetic Epidemiology Network (HyperGEN) study. Metabolism. 2007;56(8):1011-1016.

Yosipovitch G, Duque MI, Patel TS, Ishiuji Y, Guzman-Sanchez DA, Dawn AG, Freedman BI, Chan YH, Crumrine D, Elias PM. Skin barrier structure and function and their relationship to pruritus in end-stage renal disease. Nephrol Dial Transplant. 2007;22(11):3268-3272.

Moossavi S, Regan JD, Pierson ED, Kasey JM, Tuttle AB, Vachharajani TJ, Bettmann MA, Russell GB, Freedman BI. Non-surgical salvage of thrombosed arterio-venous fistulae: a case series and review of the literature. Semin Dial. 2007;20(5):459-464.

Freedman BI, Bostrom M, Daeihagh P, Bowden DW. Genetic factors in diabetic nephropathy. Clin J Am Soc Nephrol. 2007;2(6):1306-1316.

Sale MM, Smith SG, Mychaleckyj JC, Keene KL, Langefeld CD, Leak TS, Hicks PJ, Bowden DW, Rich SS, Freedman BI. Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy. Diabetes. 2007;56(10):2638-2642.

Sedro JR, Abboud HE, Freedman BI, et al. A genome-wide scan for estimated glomerular filtration rate (eGFR): the Family Investigation of Nephropathy and Diabetes (FIND) Study [abstract]. J Am Soc Nephrol. 2007;18(Abstracts Issue):14A.

Leak TS, Perlegas PS, Smith SG, Hicks PJ, Li L, Langefeld CD, Keene KL, Sale MM, Freedman BI, Bowden DW. Variants in the ELMO1 gene are associated with diabetes and nephropathy in African Americans [abstract]. J Am Soc Nephrol. 2007;18(Abstracts Issue):14A.

Salem RM, Cadman PE, Chen Y, Taupenot L, Rao F, Wen G, Hamilton BA, Bowden DW, Hicks PJ, Freedman BI, et al. Polymorphisms at the catecholamine storage vesicle biosynthetic locus chromogranin A are risk factors for hypertensive end stage renal disease [abstract]. J Am Soc Nephrol. 2007;18(Abstracts Issue):15A-16A.

Schelling JR, Bleyer AJ, Freedman BI, Sedor JR. Diabetic sibs with normal GFR and family history of diabetic nephropathy (DN) develop progressive nephropathy: a risk group for targeted intervention [abstract]. J Am Soc Nephrol. 2007;18(Abstracts Issue):571A.

Bostrom MA, Sale MM, Leak TS, Freedman BI, Bowden DW. Insulin-like growth factor binding protein 1 and 3 gene associations in African Americans with type 2 diabetic end stage renal disease [abstract]. J Am Soc Nephrol. 2007;18(Abstracts Issue):606A.

McDonough CW, Hicks PJ, Freedman BI, Bowden DW. Genetic evaluation of CNDP1 and CNDP2 polymorphisms in diabetic nephropathy [abstract]. J Am Soc Nephrol. 2007;18(Abstracts Issue):607A.

Adler S, Chew E, Freedman BI, et al. Coincident linkage peaks for nephropathy and retinopathy: the Family Investigation of Nephropathy and Diabetes (FIND) Study [abstract]. J Am Soc Nephrol. 2007;18(Abstracts Issue):607A.

Nelson RG, Nicholas SB, Freedman BI, et al. A search for diabetes genes in four ethnic groups selected for diabetic nephropathy: the Family Investigation of Nephropathy and Diabetes (FIND) Study [abstract]. J Am Soc Nephrol. 2007;18(Abstracts Issue):607A.

Iyengar SK, Freedman BI, et al. A multi-ethnic genome-wide linkage study for diabetic nephropathy. The Family Investigation of Nephropathy and Diabetes (FIND) Study [abstract]. J Am Soc Nephrol. 2007;18(Abstracts Issue):608A.

Parekh RS, Freedman BI, Bowden DW, Satko SC [sic] [Satko SG], Rich SS, Warren S, Viverette S, Brooks G, Young R, Spainhour M, et al. Reliability of urinary albumin, total protein, and creatinine assays after prolonged storage: the Family Investigation of Nephropathy and Diabetes. Clin J Am Soc Nephrol. 2007;2(6):1156-1162.

Lehtinen AB, Newton-Cheh C, Ziegler JT, Langefeld CD, Freedman BI, Daniel KR, Herrington DM, Bowden DW. Association of NOS1AP genetic variants with QT interval duration in families from the Diabetes Heart Study [abstract]. Circulation. 2007;116(16 Suppl):652-653.

Freedman BI, Bowden DW, Sale MM, Langefeld CD, Rich SS. Genetic susceptibility contributes to renal and cardiovascular complications of type 2 diabetes mellitus. Hypertension. 2006;48(1):8-13.

Register TC Lenchik L, Hsu FC, Lohman KK, Freedman BI, Bowden DW, Carr JJ. Type 2 diabetes is not independently associated with spinal trabecular volumetric bone mineral density measured by QCT in the Diabetes Heart Study. Bone. 2006;39(3):628-633.

Bowden DW, Rudock M, Ziegler J, Lehtinen AB, Xu J, Wagenknecht LE, Herrington D, Rich SS, Freedman BI, Carr JJ, Langefeld CD. Coincident linkage of type 2 diabetes, metabolic syndrome, and measures of cardiovascular disease in a genome scan of the Diabetes Heart Study. Diabetes. 2006;55(7):1985-1994.

Bowden DW, Lohman K, Hsu F-C, Langefeld CD, Carr JJ, Lenchik L, Wagenknecht LE, Freedman BI, Herrington DM. Hormone replacement therapy is associated with increased C-reactive protein in women with type 2 diabetes in the Diabetes Heart Study. Diabet Med. 2006;23(7):763-767.

Liu Y, Herrington D, Burdon KP, Langefeld CD, Rich SS, Bowden DW, Freedman BI, Wagenknecht LE. A functional polymorphism in the lymphotoxin-alpha gene is associated with carotid artery wall thickness: the Diabetes Heart Study. Eur J Cardiovasc Prev Rehabil. 2006;13(4):655-657.

Wilk JB, Myers RH, Pankow JS, Hunt SC Leppert MF, Freedman BI, Province MA, Ellison RC. Adrenergic receptor polymorphisms associated with resting heart rate: the HyperGEN Study. Ann Hum Genet. 2006;70(Pt 5):566-573.

Speckman RA, McClellan WM, Volkova NV, Jurkovitz CT, Satko SG, Schoolwerth AC, Freedman BI. Obesity is associated with family history of ESRD in incident dialysis patients. Am J Kidney Dis. 2006;48(1):50-58.

Leak TS, Mychaleckyj JC, Keene KL. Gordon CJ, Hicks PJ, Freedman BI, Bowden DW, Sale MM. A dense SNP map of human chromosome 6q24-27 to localize a type 2 diabetes gene in an African American population [abstract]. Diabetes. 2006;55(Suppl 1):A261.

Keene KL, Gallagher CJ, Mychaleckyj JC, Langefeld CD, Hirschhorn JN, Henderson BE, Freedman BI, Rich SS, Bowden DW, Sale MM, et al. Association of the estrogen receptor alpha gene with type 2 diabetes in African American and European American populations [abstract]. Diabetes. 2006;55(Suppl 1):A260.

Bowden DW, Lehtinen AB, Ziegler JT, Herrington D, Wagenknecht LE, Rich SS, Freedman BI, Carr JJ, Langefeld CD. A genome scan for subclinical cardiovascular disease in the Diabetes Heart Study [abstract]. Atheroscler Suppl. 2006;7(3):89.

Duque MI, Thevarajah S, Chan YH, Tuttle AB, Freedman BI, Yosipovitch G. Uremic pruritus is associated with higher Kt/V and serum calcium concentration. Clin Nephrol. 2006;66(3):184-191.

Avery CL, Freedman BI, Kraja AT, Borecki IB, Miller MB, Pankow JS, Arnett D, Lewis CE, Myers RH, Hung SC, et al. Genotype-by-sex interaction in the aetiology of type 2 diabetes mellitus: support for sex-specific quantitative trait loci in Hypertension Genetic Epidemiology Network participants. Diabetologia. 2006;49(10):2329-2336.

Rich SS, Burdon KP, Langefeld CD, Liu Y, Freedman BI, Carr JJ, Hedrick CC, Bowden DW. Human lipoxygenase gene variation in subclinical atherosclerosis: the Diabetes Heart Study [abstract]. Atheroscler Suppl. 2006;7(3):335.

Freedman BI, Hsu FC, Lohman K, Bowden DW, Leonchik L [sic] [Lenchik L], Langefeld CD, Xu J, Register Tc, Rich SS, Wagenknecht LE. The relationship between calcified atherosclerotic plaque and bone mineral density: the Diabetes Heart Study [abstract]. Atheroscler Suppl. 2006;7(3):14.

Elbein SC, Wang X, Karim MA, Freedman BI, Bowden DW, Shuldiner AR, Brancati FL, Kao WHL. Role of a proline insertion in the insulin promoter factor 1 (IPF1) gene in African Americans with type 2 diabetes. Diabetes. 2006;55(10):2909-2914.

Lange LA, Burdon K, Langefeld CD, Liu Y, Beck SR, Rich SS, Freedman BI, Brosnihan KB, Herrington DM, Wagenknecht LE, Bowden DW. Heritability and expression of C-reactive protein in type 2 diabetes in the Diabetes Heart Study. Ann Hum Genet. 2006;70(Pt 6):717-725.

Bleyer AJ, Sedor JR, Freedman BI, Schelling JR. Screening diabetic siblings of diabetic end-stage kidney disease patients reveals frequent uncontrolled hypertension, uncontrolled diabetes, and albuminuria [abstract]. J Am Soc Nephrol. 2006;17(Abstr Issue):82A.

Freedman BI, Bowden DW, Rich SS, Wagenknecht LE, Ziegler J, Sale MM, Langefeld CD. Genome scans for glomerular filtration rate (GFR) and albuminuria: the Diabetes Heart Study (DHS) [abstract]. J Am Soc Nephrol. 2006;17(Abstr Issue):84A.

Hicks PJ, Staten JL, Sale MM, Bowden DW, Freedman BI. The ephrin-B2 gene is not associated with end-stage renal disease (ESRD) in African Americans (AA) [abstract]. J Am Soc Nephrol. 2006;17(Abstr Issue):148A.

Freedman BI, Hicks PJ, Sale MM, Pierson ED, Langefeld CD, Rich SS, Janssen B, Yard BA, van der Woude FJ. A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic nephropathy (DN) in European Americans (EA) [abstract]. J Am Soc Nephrol. 2006;17(Abstr Issue):391A.

Freedman BI, Tuttle AB, Plonk GW, Bettmann MA, Majekodunmi O, Russell GB, Regan JD. Long-term outcomes of transposed basilic vein arterio-venous fistulae (TBAVF) [abstract]. J Am Soc Nephrol. 2006;17(Abstr Issue):497A.

Moossavi S, Regan JD, Pierson ED, Kasey JM, Tuttle AB, Bettmann MA, Russell GB, Freedman BI. Non-surgical salvage of thrombosed arterio-venous fistulae (AVF) [abstract]. J Am Soc Nephrol. 2006;17(Abstr Issue):500A.

Schelling JR, Sedor JR, Freedman BI, Rich SS, Iyengar SK, Bleyer AJ. The Family Investigation of Nephropathy and Diabetes (FIND) longitudinal follow-up study: design and preliminary results [abstract]. J Am Soc Nephrol. 2006;17(Abstr Issue):707A.

Saran A, Carr JJ, Lohman KK, Hsu F-C, Bowden DW, Freedman BI. Renal volume (RV) is associated with sub-clinical atherosclerosis in type 2 diabetes: the Diabetes Heart Study (DHS) [abstract]. J Am Soc Nephrol. 2006;17(Abstr Issue):584A.

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For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Nephrology

Clinical Specialties

Atherosclerosis, Genetic Factors in Kidney Disease and Diabetes, Diabetes, Clinical Nephrology, Hypertension, Kidney Disease, Nephrology
Barry I. Freedman, M.D.
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