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David P. Friedman, Ph.D.Wake Forest School of Medicine

David P. Friedman, Ph.D.

Associate Dean, Office of Research
Professor,

Contact Information

Academic: 336-713-7186 | Department: 336-713-7186

Email: dfriedmn@wakehealth.edu

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Additional Languages

Spanish

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Education & Training

  • B.S., University of Pittsburgh, 1968
  • M.S., New York Medical College, 1977
  • Ph.D., New York Medical College, 1978
  • Fellowship, Washington University School o, 1980
  • Fellowship, Natl Inst Of Mental Health, 1983

Memberships

  • Am Assn for the Adv of Science
  • Research Society On Alcoholism
  • Society for Neuroscience
David P. Friedman, Ph.D.

David P. Friedman, Ph.D.

Associate Dean, Office of Research
Professor, Physiology & Pharmacology

Research Interests

Ethanol; Central Nervous System Depressants; Alcoholism; Brain; Hippocampus
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Contact Information

Academic: 336-713-7186 | Department: 336-713-7186

Email: dfriedmn@wakehealth.edu

Media Medical Expert »

Related Links

Recent Publications

Multi-atlas library for eliminating normalization failures in non-human primates. Maldjian JA, Shively CA, Nader MA, Friedman DP, Whitlow CT.. Neuroinformatics. 2016;14(2):183-190.

The effects of chronic alcohol self-administration in nonhuman primate brain networks. Telesford QK, Laurienti PJ, Davenport AT, Friedman DP, Kraft RA, Daunais JB.. Alcohol Clin Exp Res. 2015;39(4):659-671.

Disruption of early stage resting state activity as a function of alcohol consumption in nonhuman primates: an MEG study [abstract]. Stapleton-Kotloski JR, Rowland JA, Davenport AT, Epperly PM, Friedman DP, Godwin DW, Daunais JB.. Soc Neurosci Abstr. 2015;2015(Neuroscience Meeting Planner):.

The effects of chronic ethanol self-administration on hippocampal 5-HT1A receptors in monkeys. Burnett EJ, Grant KA, Davenport AT, Hemby SE, Friedman DP.. Drug Alcohol Depend. 2014;136():135-142.

Standardized method for the harvest of nonhuman primate tissue optimized for multiple modes of analyses. Davenport AT, Grant KA, Szeliga KT, Friedman DP, Daunais JB.. Cell Tissue Bank. 2014;15(1):99-110.

Monkey alcohol tissue research resource: banking tissues for alcohol research. Daunais JB, Davenport AT, Helms CM, Gonzales SW, Hemby SE, Friedman DP, Farro JP, Baker EJ, Grant KA.. Alcohol Clin Exp Res. 2014;38(7):1973-1981.

Vervet MRI atlas and label map for fully automated morphometric analyses. Maldjian JA, Daunais JB, Friedman DP, Whitlow CT.. Neuroinformatics. 2014;12(4):543-550.

The effects of alcohol on the nonhuman primate brain: a network science approach to neuroimaging. Telesford QK, Laurienti PJ, Friedman DP, Kraft RA, Daunais JB.. Alcohol Clin Exp Res. 2013;37(11):1891-1900.

Alternative splicing of AMPA subunits in prefrontal cortical fields of cynomolgus monkeys following chronic ethanol self-administration. Acosta G, Freidman DR [sic] [Friedman DR], Grant KA, Hemby SE.. Front Psychiatry. 2012;2():72.

Disruptions in serotonergic regulation of cortical glutamate release in primate insular cortex in response to chronic ethanol and nursery rearing. Alexander GM, Graef JD, Hammarback JA, Nordskog BK, Burnett EJ, Daunais JB, Bennett AJ, Friedman DP, Suomi SJ, Godwin DW.. Neuroscience. 2012;207():167-181.

The effects of chronic ethanol self-administration on hippocampal serotonin transporter density in monkeys. Burnett EJ, Davenport AT, Grant KA, Friedman DP.. Front Psychiatry. 2012;3():article 38.

Effects of early life stress on drinking and serotonin system activity in rhesus macaques: 5-hydroxyindoleacetic acid in cerebrospinal fluid predicts brain tissue levels. Huggins KN, Mathews TA, Locke JL, Szeliga KT, Friedman DP, Bennett AJ, Jones SR.. Alcohol. 2012;46(4):371-376.

Long-term effects of differential early rearing in rhesus macaques: behavioral reactivity in adulthood. Corcoran CA, Pierre PJ, Haddad T, Bice C, Suomi SJ, Grant KA, Friedman DP, Bennett AJ.. Dev Psychobiol. 2012;54(5):546-555.

Ethanol-induced differential gene expression of 5-HT1A and YIF1B in hippocampal pyramidal and granule cells in cynomolgus macaques [abstract]. Burnett EJ, Darmon M, Grant KA, Friedman DP, Hemby SE.. Alcohol Clin Exp Res. 2012;36(Suppl 1):259A.

Ethanol-induced regulation of iGluR and GABAA subunit mRNAs in prefrontal fields of cynomolgus monkey [abstract]. Hemby SE, McCool B, Friedman DP, Helms CM.. Alcohol Clin Exp Res. 2012;36(Suppl 2):39A.

The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells. Provencal N, Suderman MJ, Guillemin C, Massart R, Ruggiero A, Wang D, Bennett AJ, Pierre PJ, Friedman DP, Cote SM, Hallett M, Tremblay RE, Suomi SJ, Szyf M.. J Neurosci. 2012;32(44):15626-42.

Downregulation of SR Ca2+-ATPase as a contributing cause of impaired cardiomyocyte basal and beta-adrenergic regulation of [Ca2+]i with myocyte dysfunction in monkeys with chronic heavy alcohol consumption [abstract]. Wajih N, Cheng H-J, Zhou P, Daunais JB, Friedman DP, Little WC, Grant KA, Cheng CP.. Circulation. 2011;124(21 Suppl):A9254.

Hippocampal 5-HT(1A) receptor density following chronic ethanol self-administration in cynomolgus macaques [abstract]. Burnett EJ, Davenport AT, Grant KA, Friedman DP.. Alcohol Clin Exp Res. 2011;35(6 Suppl):125A.

Impact of chronic ethanol self-administration on white matter in vervet monkey brain: a diffusion tensor imaging study [abstract]. Daunais JB, Davenport AT, Brunett EJ, Maxey VM, Trimnal MW, Dolson EP, Clissold KA, Kraft RA, Friedman DP.. Alcohol Clin Exp Res. 2011;35(6 Suppl):125A.

Monkey alcohol tissue research resource [abstract]. Daunais JB, Davenport AT, Hemby SE, Friedman DP, Baker EJ, Grant KA.. Alcohol Clin Exp Res. 2011;35(6 Suppl):123A.

Chronic ethanol alters GABA(A) receptor and alpha subunit density in the monkey superior temporal sulcus, inferior temporal gyrus, and insula [abstract]. Dolson EP, Davenport AT, Grant KA, Friedman DP.. Alcohol Clin Exp Res. 2011;35(6 Suppl):64A.

The effects of acute and chronic ethanol exposure in nonhuman primate brain networks [abstract]. Telesford QK, Wyatt CL, Kraft RA, Friedman DP, Laurienti PJ, Daunais JB.. Alcohol Clin Exp Res. 2011;35(6 Suppl):126A.

Ethanol self-administration modulation of NMDA receptor subunit and related synaptic protein mRNA expression in prefrontal cortical fields in cynomolgus monkeys. Acosta G, Hasenkamp W, Daunais JB, Friedman DP, Grant KA, Hemby SE.. Brain Res. 2010;1318():144-154.

MRI-guided dissection of the nonhuman primate brain: a case study. Daunais JB, Kraft RA, Davenport AT, Burnett EJ, Maxey VM, Szeliga KT, Rau AR, Flory GS, Hemby SE, Friedman DP, et al.. Methods. 2010;50(3):199-204.

Up-regulation and functional effect of cardiac beta(3)-adrenoreceptors in alcoholic monkeys. Cheng H-J, Grant KA, Han Q-H, Daunais JB, Friedman DP, Masutani S, Little WC, Cheng C-P.. Alcohol Clin Exp Res. 2010;34(7):1171-1181.

Low behavioral and physiological stress response to novelty is associated with HPA axis hyporesponsivity and increased alcohol consumption in vervet monkeys (Cercopithecus aethiops) [abstract]. Burnett EJ, Davenport AT, Dolson EP, Trimnal MW, Fairbanks LA, Friedman DP.. Am J Primatol. 2010;72(Suppl 1):46.

Vervet monkeys with a low behavioral and physiological stress response to novelty exhibit HPA axis hyporesponsivity and increased alcohol consumption [abstract]. Burnett EJ, Davenport AT, Maxey VM, Dolson EP, Trimnal MW, Fairbanks LA, Friedman DP.. Alcohol Clin Exp Res. 2010;34(6 Suppl 2):201A.

Chronic ethanol alters GABA(A) receptor and alpha subunit density in the monkey subicular complex [abstract]. Dolson EP, Davenport AT, Grant KA, Friedman DP.. Alcohol Clin Exp Res. 2010;34(6 Suppl 2):194A.

Disruptions in serotonergic regulation of cortical glutamate release in primate insular cortex in response to chronic ethanol and early life stress [abstract]. Graef JD, Alexander GM, Hammarback JA, Nordskog BK, Burnett EJ, Daunais JB, Friedman DP, Godwin DW.. Alcohol Clin Exp Res. 2010;34(6 Suppl 2):28A.

Chronic ethanol self administration but not early life stress alters corticotropin releasing hormone receptor binding density in monkey amygdala [abstract]. Trimnal BS, Megan W [sic] [Trimnal MW], Davenport AT, Burnett EJ, Maxey VM.. Alcohol Clin Exp Res. 2010;34(6 Suppl 2):136A.

Ethanol metabolism in vervet monkeys (Cercopithecus aethiops) [abstract]. Burnett EJ, Davenport AT, Maxey VM, Dolson EP, Friedman DP.. Alcohol Clin Exp Res. 2009;33(6 Special Issue):201A.

Drug addiction: a chronically relapsing brain disease [commentary]. Friedman DP.. N C Med J. 2009;70(1):35-37.

Effect of chronic ethanol on 5HT1(A) densities and serotonin transporter levels in the dorsal raphe of mother-reared vs nursery-reared macaques [abstract]. Friedman DP, Dolson EP, Maxey VM, Burnett EG [sic] [Burnett EJ], Daunais JB, Davenport AT.. Alcohol Clin Exp Res. 2009;33(6 Special Issue):23A.

Dopamine and serotonin neurochemistry in long-term alcohol drinking nursery and mother reared monkeys [abstract]. Mathews TA, Locke J, Friedman DP, Jones SR.. Alcohol Clin Exp Res. 2009;33(6 Special Issue):23A.

Functional significance of cardiac beta3 adrenergic receptors in alcoholic cardiomyopathy [abstract]. Cheng C-P, Cheng H-J, Masutani S, Hundley WG, Daunais JB, Friedman DP, Grant KA.. J Card Fail. 2009;15(Suppl 6):S42.

Anterior hippocampal volume is reduced in behaviorally depressed female cynomolgus macaques. Willard SL, Friedman DP, Henkel CK, Shively CA.. Psychoneuroendocrinology. 2009;34(10):1469-1475.

The effects of ethanol consumption on vasculogenesis potential in nonhuman primates. Williams JK, Baptista PM, Daunais JB, Szeliga KT, Friedman DP, Soker S.. Alcohol Clin Exp Res. 2008;32(1):155-161.

Anterior hippocampal volume is reduced in behaviorally depressed female macaca fascicularis living in social groups [abstract]. Willard SL, Glover EJ, Friedman DP, Henkel CK, Shively CA.. Am J Primatol. 2008;70(Suppl 1):25.

Effect of chronic ethanol on 5HT1A densities and serotonin transporter levels in the prefrontal cortex of mother-reared vs nursery-reared macaques [abstract]. Davenport AT, Maxey VM, Daunais JB, Friedman DP.. Alcohol Clin Exp Res. 2008;32(Suppl 1):34A.

Alterations in ionotropic glutamate receptor subunit abundances in prefrontal cortex following ethanol self-administration in male cynomolgus monkeys [abstract]. Egan K, Acosta G, Horman B, Friedman DP, Grant KA, Hemby SE.. Alcohol Clin Exp Res. 2008;32(6 Suppl 1):152A.

Nursery-reared monkeys have fewer amygdalar serotonin transporters and 5-HT1A receptors than mother-reared controls following chronic ethanol exposure [abstract]. Glover EJ, Davenport AT, Maxey VM, Friedman DP.. Alcohol Clin Exp Res. 2008;32(6 Suppl 1):34A.

A neurochemical comparison of striatal dopamine function in drinking monkeys [abstract]. Mathews TA, Brookshire BR, Budygin EA, Daunais JB, Friedman DP, Jones SR.. Alcohol Clin Exp Res. 2008;32(6 Suppl 1):35A.

Norepinephrinergic afferents and cytology of the macaque monkey midline, mediodorsal, and intralaminar thalamic nuclei. Vogt BA, Hof PR, Friedman DP, Sikes RW, Vogt LJ.. Brain Struct Funct. 2008;212(6):465-479.

Changes in amygdala volume associated with early life stress in rhesus macaques (Macaca mulatta) [abstract]. Burnett EJ, Friedman DP, Daunais JB.. Soc Neurosci Abstr. 2008;2008(Neuroscience Meeting Planner):.

Public outreach: a scientific imperative [commentary]. Friedman DP.. J Neurosci. 2008;28(46):11743-45.

Ethanol self-administration and alterations in the livers of the cynomolgus monkey, Macaca fascicularis. Ivester P, Roberts LJ II, Young T, Vivian J, Lees C, Young J, Daunais J, Friedman D, Grant KA, Cunningham C, et al.. Alcohol Clin Exp Res. 2007;31(1):144-155.

Long-term ethanol self-administration by the nonhuman primate, Macaca fascicularis, decreases the benzodiazepine sensitivity of amygdala GABA(A) receptors. Anderson NJ, Daunais JB, Friedman DP, Grant KA, McCool BA.. Alcohol Clin Exp Res. 2007;31(6):1061-1070.

Ethanol-induced volume changes in Macaque brain [abstract]. Daunais JB, Liu W, Wyatt CL, Szeliga KT, Buchheimer NC, Gage HD, Kraft RA, Friedman DP.. Alcohol Clin Exp Res. 2007;31(6 Suppl):147A.

Increases in alcohol consumption rates associated with early chronic stress: is it about alcohol or about consumption? Preliminary evidence [abstract]. Mandell DJ, Bennett AJ, Szeliga KT, Pierre PJ, Suomi SJ, Grant KA, Friedman DP.. Alcohol Clin Exp Res. 2007;31(6 Suppl):22A.

Reduced anterior hippocampal volume in behaviorally depressed female cynomolgus macaques (Macaca fascicularis) [abstract]. Willard SL, Glover EJ, Friedman DP, Henkel CK, Shively CA.. Soc Neurosci Abstr. 2007;2007(Abstr Viewer):.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

David P. Friedman, Ph.D.

David P. Friedman, Ph.D.

Associate Dean, Office of Research
Professor, Physiology & Pharmacology

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