Profile

David P. Friedman, Ph.D.

David P. Friedman, Ph.D.

Professor, Physiology & Pharmacology
WFU Primate Center

Contact Information

Academic: 336-713-7186 | Department: 336-713-7186

Email: dfriedmn@wakehealth.edu

Media Medical Expert »

Additional Languages

Spanish

Education & Training

  • Ph.D., New York Medical College , 1978
  • B.S., University of Pittsburgh , 1968
  • M.S., New York Medical College , 1977
  • Fellowship, Washington University School of Medicine, 1980
  • Fellowship, Natl Inst Of Mental Health, 1983

Memberships

  • Am Assn for the Adv of Science
  • Research Society On Alcoholism
  • Society for Neuroscience
David P. Friedman, Ph.D.

David P. Friedman, Ph.D.

Professor, Physiology & Pharmacology WFU Primate Center

Contact Information

Academic: 336-713-7186 | Department: 336-713-7186

Email: dfriedmn@wakehealth.edu

Media Medical Expert »

Recent Publications

Acosta G, Freidman DR [sic] [Friedman DR], Grant KA, Hemby SE. Alternative splicing of AMPA subunits in prefrontal cortical fields of cynomolgus monkeys following chronic ethanol self-administration. Front Psychiatry. 2012;2():72.

Alexander GM, Graef JD, Hammarback JA, Nordskog BK, Burnett EJ, Daunais JB, Bennett AJ, Friedman DP, Suomi SJ, Godwin DW. Disruptions in serotonergic regulation of cortical glutamate release in primate insular cortex in response to chronic ethanol and nursery rearing. Neuroscience. 2012;207():167-181.

Burnett EJ, Davenport AT, Grant KA, Friedman DP. The effects of chronic ethanol self-administration on hippocampal serotonin transporter density in monkeys. Front Psychiatry. 2012;3():article 38.

Huggins KN, Mathews TA, Locke JL, Szeliga KT, Friedman DP, Bennett AJ, Jones SR. Effects of early life stress on drinking and serotonin system activity in rhesus macaques: 5-hydroxyindoleacetic acid in cerebrospinal fluid predicts brain tissue levels. Alcohol. 2012;46(4):371-376.

Corcoran CA, Pierre PJ, Haddad T, Bice C, Suomi SJ, Grant KA, Friedman DP, Bennett AJ. Long-term effects of differential early rearing in rhesus macaques: behavioral reactivity in adulthood. Dev Psychobiol. 2012;54(5):546-555.

Burnett EJ, Darmon M, Grant KA, Friedman DP, Hemby SE. Ethanol-induced differential gene expression of 5-HT1A and YIF1B in hippocampal pyramidal and granule cells in cynomolgus macaques [abstract]. Alcohol Clin Exp Res. 2012;36(Suppl 1):259A.

Hemby SE, McCool B, Friedman DP, Helms CM. Ethanol-induced regulation of iGluR and GABAA subunit mRNAs in prefrontal fields of cynomolgus monkey [abstract]. Alcohol Clin Exp Res. 2012;36(Suppl 2):39A.

Provencal N, Suderman MJ, Guillemin C, Massart R, Ruggiero A, Wang D, Bennett AJ, Pierre PJ, Friedman DP, Cote SM, Hallett M, Tremblay RE, Suomi SJ, Szyf M. The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells. J Neurosci. 2012;32(44):15626-42.

Wajih N, Cheng H-J, Zhou P, Daunais JB, Friedman DP, Little WC, Grant KA, Cheng CP. Downregulation of SR Ca2+-ATPase as a contributing cause of impaired cardiomyocyte basal and beta-adrenergic regulation of [Ca2+]i with myocyte dysfunction in monkeys with chronic heavy alcohol consumption [abstract]. Circulation. 2011;124(21 Suppl):A9254.

Burnett EJ, Davenport AT, Grant KA, Friedman DP. Hippocampal 5-HT(1A) receptor density following chronic ethanol self-administration in cynomolgus macaques [abstract]. Alcohol Clin Exp Res. 2011;35(6 Suppl):125A.

Daunais JB, Davenport AT, Brunett EJ, Maxey VM, Trimnal MW, Dolson EP, Clissold KA, Kraft RA, Friedman DP. Impact of chronic ethanol self-administration on white matter in vervet monkey brain: a diffusion tensor imaging study [abstract]. Alcohol Clin Exp Res. 2011;35(6 Suppl):125A.

Daunais JB, Davenport AT, Hemby SE, Friedman DP, Baker EJ, Grant KA. Monkey alcohol tissue research resource [abstract]. Alcohol Clin Exp Res. 2011;35(6 Suppl):123A.

Dolson EP, Davenport AT, Grant KA, Friedman DP. Chronic ethanol alters GABA(A) receptor and alpha subunit density in the monkey superior temporal sulcus, inferior temporal gyrus, and insula [abstract]. Alcohol Clin Exp Res. 2011;35(6 Suppl):64A.

Telesford QK, Wyatt CL, Kraft RA, Friedman DP, Laurienti PJ, Daunais JB. The effects of acute and chronic ethanol exposure in nonhuman primate brain networks [abstract]. Alcohol Clin Exp Res. 2011;35(6 Suppl):126A.


Daunais JB, Kraft RA, Davenport AT, Burnett EJ, Maxey VM, Szeliga KT, Rau AR, Flory GS, Hemby SE, Friedman DP, et al. MRI-guided dissection of the nonhuman primate brain: a case study. Methods. 2010;50(3):199-204.

Cheng H-J, Grant KA, Han Q-H, Daunais JB, Friedman DP, Masutani S, Little WC, Cheng C-P. Up-regulation and functional effect of cardiac beta(3)-adrenoreceptors in alcoholic monkeys. Alcohol Clin Exp Res. 2010;34(7):1171-1181.

Burnett EJ, Davenport AT, Dolson EP, Trimnal MW, Fairbanks LA, Friedman DP. Low behavioral and physiological stress response to novelty is associated with HPA axis hyporesponsivity and increased alcohol consumption in vervet monkeys (Cercopithecus aethiops) [abstract]. Am J Primatol. 2010;72(Suppl 1):46.

Burnett EJ, Davenport AT, Maxey VM, Dolson EP, Trimnal MW, Fairbanks LA, Friedman DP. Vervet monkeys with a low behavioral and physiological stress response to novelty exhibit HPA axis hyporesponsivity and increased alcohol consumption [abstract]. Alcohol Clin Exp Res. 2010;34(6 Suppl 2):201A.

Dolson EP, Davenport AT, Grant KA, Friedman DP. Chronic ethanol alters GABA(A) receptor and alpha subunit density in the monkey subicular complex [abstract]. Alcohol Clin Exp Res. 2010;34(6 Suppl 2):194A.

Graef JD, Alexander GM, Hammarback JA, Nordskog BK, Burnett EJ, Daunais JB, Friedman DP, Godwin DW. Disruptions in serotonergic regulation of cortical glutamate release in primate insular cortex in response to chronic ethanol and early life stress [abstract]. Alcohol Clin Exp Res. 2010;34(6 Suppl 2):28A.

Trimnal BS, Megan W [sic] [Trimnal MW], Davenport AT, Burnett EJ, Maxey VM. Chronic ethanol self administration but not early life stress alters corticotropin releasing hormone receptor binding density in monkey amygdala [abstract]. Alcohol Clin Exp Res. 2010;34(6 Suppl 2):136A.

Burnett EJ, Davenport AT, Maxey VM, Dolson EP, Friedman DP. Ethanol metabolism in vervet monkeys (Cercopithecus aethiops) [abstract]. Alcohol Clin Exp Res. 2009;33(6 Special Issue):201A.

Friedman DP. Drug addiction: a chronically relapsing brain disease [commentary]. N C Med J. 2009;70(1):35-37.

Friedman DP, Dolson EP, Maxey VM, Burnett EG [sic] [Burnett EJ], Daunais JB, Davenport AT. Effect of chronic ethanol on 5HT1(A) densities and serotonin transporter levels in the dorsal raphe of mother-reared vs nursery-reared macaques [abstract]. Alcohol Clin Exp Res. 2009;33(6 Special Issue):23A.

Mathews TA, Locke J, Friedman DP, Jones SR. Dopamine and serotonin neurochemistry in long-term alcohol drinking nursery and mother reared monkeys [abstract]. Alcohol Clin Exp Res. 2009;33(6 Special Issue):23A.

Cheng C-P, Cheng H-J, Masutani S, Hundley WG, Daunais JB, Friedman DP, Grant KA. Functional significance of cardiac beta3 adrenergic receptors in alcoholic cardiomyopathy [abstract]. J Card Fail. 2009;15(Suppl 6):S42.

Willard SL, Friedman DP, Henkel CK, Shively CA. Anterior hippocampal volume is reduced in behaviorally depressed female cynomolgus macaques. Psychoneuroendocrinology. 2009;34(10):1469-1475.

Williams JK, Baptista PM, Daunais JB, Szeliga KT, Friedman DP, Soker S. The effects of ethanol consumption on vasculogenesis potential in nonhuman primates. Alcohol Clin Exp Res. 2008;32(1):155-161.

Willard SL, Glover EJ, Friedman DP, Henkel CK, Shively CA. Anterior hippocampal volume is reduced in behaviorally depressed female macaca fascicularis living in social groups [abstract]. Am J Primatol. 2008;70(Suppl 1):25.

Davenport AT, Maxey VM, Daunais JB, Friedman DP. Effect of chronic ethanol on 5HT1A densities and serotonin transporter levels in the prefrontal cortex of mother-reared vs nursery-reared macaques [abstract]. Alcohol Clin Exp Res. 2008;32(Suppl 1):34A.

Egan K, Acosta G, Horman B, Friedman DP, Grant KA, Hemby SE. Alterations in ionotropic glutamate receptor subunit abundances in prefrontal cortex following ethanol self-administration in male cynomolgus monkeys [abstract]. Alcohol Clin Exp Res. 2008;32(6 Suppl 1):152A.

Glover EJ, Davenport AT, Maxey VM, Friedman DP. Nursery-reared monkeys have fewer amygdalar serotonin transporters and 5-HT1A receptors than mother-reared controls following chronic ethanol exposure [abstract]. Alcohol Clin Exp Res. 2008;32(6 Suppl 1):34A.

Mathews TA, Brookshire BR, Budygin EA, Daunais JB, Friedman DP, Jones SR. A neurochemical comparison of striatal dopamine function in drinking monkeys [abstract]. Alcohol Clin Exp Res. 2008;32(6 Suppl 1):35A.

Vogt BA, Hof PR, Friedman DP, Sikes RW, Vogt LJ. Norepinephrinergic afferents and cytology of the macaque monkey midline, mediodorsal, and intralaminar thalamic nuclei. Brain Struct Funct. 2008;212(6):465-479.

Burnett EJ, Friedman DP, Daunais JB. Changes in amygdala volume associated with early life stress in rhesus macaques (Macaca mulatta) [abstract]. Soc Neurosci Abstr. 2008;2008(Neuroscience Meeting Planner):.

Friedman DP. Public outreach: a scientific imperative [commentary]. J Neurosci. 2008;28(46):11743-45.

Ivester P, Roberts LJ II, Young T, Vivian J, Lees C, Young J, Daunais J, Friedman D, Grant KA, Cunningham C, et al. Ethanol self-administration and alterations in the livers of the cynomolgus monkey, Macaca fascicularis. Alcohol Clin Exp Res. 2007;31(1):144-155.

Anderson NJ, Daunais JB, Friedman DP, Grant KA, McCool BA. Long-term ethanol self-administration by the nonhuman primate, Macaca fascicularis, decreases the benzodiazepine sensitivity of amygdala GABA(A) receptors. Alcohol Clin Exp Res. 2007;31(6):1061-1070.

Daunais JB, Liu W, Wyatt CL, Szeliga KT, Buchheimer NC, Gage HD, Kraft RA, Friedman DP. Ethanol-induced volume changes in Macaque brain [abstract]. Alcohol Clin Exp Res. 2007;31(6 Suppl):147A.

Mandell DJ, Bennett AJ, Szeliga KT, Pierre PJ, Suomi SJ, Grant KA, Friedman DP. Increases in alcohol consumption rates associated with early chronic stress: is it about alcohol or about consumption? Preliminary evidence [abstract]. Alcohol Clin Exp Res. 2007;31(6 Suppl):22A.

Willard SL, Glover EJ, Friedman DP, Henkel CK, Shively CA. Reduced anterior hippocampal volume in behaviorally depressed female cynomolgus macaques (Macaca fascicularis) [abstract]. Soc Neurosci Abstr. 2007;2007(Abstr Viewer):.

Davenport AT, Szeliga KT, Moser VM, Daunais JB, Friedman DP. Effect of chronic ethanol on 5HT1A and serotonin transporter densities in the hippocampus and raphe of mother-reared vs peer-reared macaques [abstract]. Alcohol Clin Exp Res. 2007;31(Suppl 2):208A.

Carden WB, Alexander GM, Friedman DP, Daunais JB, Grant KA, Mu J, Godwin DW. Chronic ethanol drinking reduces native T-type calcium current in the thalamus of nonhuman primates. Brain Res. 2006;1089():92-100.

Alexander GM, Carden WB, Mu J, Kurukulasuriya NC, McCool BA, Nordskog BK, Friedman DP, Daunais JB, Grant KA, Godwin DW. The native T-type calcium current in relay neurons of the primate thalamus. Neuroscience. 2006;141(1):453-461.

Friedman DP, Szeliga KT, Maxey VM, Grant KA. Increased ethanol self-administration in nursery-reared monkeys [abstract]. Alcohol Clin Exp Res. 2006;30(6 Suppl):187A.

Szeliga KT, Maxey VM, Davenport A, Bennett A, Grant KA, Friedman DP. Nursery-reared rhesus monkeys have blunted neuroendocrine responses compared to mother-reared monkeys [abstract]. Alcohol Clin Exp Res. 2006;30(6 Suppl):78A.

Shively CA, Register TC, Friedman DP, Gage HD, Bounds MC, Clarkson TB. Neurobiological substrates of a relationship between depression and atherosclerosis in adult female cynomolgus monkeys (Macaca fascicularis) [abstract]. Am J Primatol. 2006;68(Suppl 1):36-37.

Hemby SE, O'Connor JA, Acosta G, Floyd D, Anderson N, McCool BA, Friedman D, Grant KA. Ethanol-induced regulation of GABA subunit mRNAs in prefrontal fields of cynomolgus monkeys. Alcohol Clin Exp Res. 2006;30(12):1978-1985.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Physiology & Pharmacology

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