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Cristina Maria Furdui, Ph.D.Wake Forest School of Medicine

Cristina Maria Furdui, Ph.D.

Associate Professor,

Contact Information

Academic: 336-716-2697 | Department: 336-716-2011

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Education & Training

  • Ph.D., University of Nebraska-Lincoln, 2002
  • Fellowship, Yale University, 2004
Cristina Maria Furdui, Ph.D.

Cristina Maria Furdui, Ph.D.

Associate Professor, Molecular Medicine
Office of Women in Medicine and Science

Research Interests

Sulfenic Acids; Cysteine; Proteins; Spectrometry, Mass, Electrospray Ionization; Proto-Oncogene Proteins c-akt
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Contact Information

Academic: 336-716-2697 | Department: 336-716-2011

Related Links

Recent Publications

Biological chemistry and functionality of protein sulfenic acids and related thiol modifications. Devarie-Baez NO, Silva Lopez E, Furdui CM.. Free Radic Res. 2016;50(2):172-194.

Cysteine-mediated redox regulation of cell signaling in chondrocytes stimulated with fibronectin fragments. Wood ST, Long DL, Reisz JA, Yammani RR, Burke EA, Klomsiri C, Poole LB, Furdui CM, Loeser RF.. Arthritis Rheumatol. 2016;68(1):117-126.

Crystal structure and substrate specificity of human thioesterase 2: insights into the molecular basis for the modulation of fatty acid synthase. Ritchie MK, Johnson LC, Clodfelter JE, Pemble CW IV, Fulp BE, Furdui CM, Kridel SJ, Lowther WT.. J Biol Chem. 2016;291(7):3520-3530.

The human pancreas as a source of protolerogenic extracellular matrix scaffold for a new-generation bioartificial endocrine pancreas. Peloso A, Urbani L, Cravedi P, Katari R, Maghsoudlou P, Fallas ME, Sordi V, Citro A, Purroy C, Niu G, McQuilling JP, Sittadjody S, Farney AC, Iskandar SS, Zambon JP, Rogers J, Stratta RJ, Opara EC, Piemonti L, Furdui CM, Soker S, De Coppi P, Orlando G.. Ann Surg. 2016;264(1):169-179.

Characterization of circulating APOL1 protein complexes in African Americans. Weckerle A, Snipes JA, Cheng D, Gebre AK, Reisz JA, Murea M, Shelness GS, Hawkins GA, Furdui CM, Freedman BI, Parks JS, Ma L.. J Lipid Res. 2016;57(1):120-130.

Oxidative stress promotes peroxiredoxin hyperoxidation and attenuates pro-survival signalling in aging chondrocytes. Collins JA, Wood ST, Nelson KJ, Rowe MA, Carlson CS, Chubinskaya S, Poole LB, Furdui CM, Loeser RF.. J Biol Chem. 2016;291(13):6641-6654.

Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice. Zhang T, Pereyra AS, Wang ZM, Birbrair A, Reisz JA, Files DC, Purcell L, Feng X, Messi ML, Feng H, Chalovich J, Jin JP, Furdui C, Delbono O.. Aging Cell. 2016;15(3):488-498.

The role of red blood cell S-nitrosation in nitrite bioactivation and its modulation by leucine and glucose. Wajih N, Liu X, Shetty P, Basu S, Wu H, Hogg N, Patel RP, Furdui CM, Kim-Shapiro DB.. Redox Biol. 2016;8():415-421.

The level of reactive oxygen species differentially regulates peroxiredoxin oxidation and mitogen-activated protein kinase signaling in human chondrocytes [abstract]. Collins JA, Wood ST, Poole L, Furdui C, Loeser R.. Osteoarthritis Cartilage. 2016;24(Suppl):S179-S180.

Pulmonary contusion decreases SIRT1 and primes the lung for a second hit [abstract]. Hoth JJ, Furdui CM, Wells JD, Yoza B, McCall C.. Shock. 2016;45(6 Suppl 1):85.

Mass spectrometry in studies of protein thiol chemistry and signaling: opportunities and caveats. Devarie Baez NO, Reisz JA, Furdui CM.. Free Radic Biol Med. 2015;80():191-211.

Dissecting peroxiredoxin catalysis: separating binding, peroxidation, and resolution for a bacterial AhpC. Parsonage D, Nelson KJ, Ferrer-Sueta G, Alley S, Karplus PA, Furdui CM, Poole LB.. Biochemistry. 2015;54(7):1567-1575.

Energy metabolism in a matched model of radiation resistance for head and neck squamous cell cancer. Mims J, Bansal N, Bharadwaj MS, Chen X, Molina AJ, Tsang AW, Furdui CM.. Radiat Res. 2015;183(3):291-304.

Analysis of DNA methylation and gene expression in radiation-resistant head and neck tumors. Chen X, Liu L, Mims J, Punska EC, Williams KE, Zhao W, Arcaro KF, Tsang AW, Zhou X, Furdui CM.. Epigenetics. 2015;10(6):545-561.

Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells. Swanner J, Mims J, Carroll DL, Akman SA, Furdui CM, Torti SV, Singh RN.. Int J Nanomedicine. 2015;10():3937-3953.

Mitochondrial reactive oxygen species (ROS) promote hyperoxidation of peroxiredoxins and inhibit pro-survival IGF-1 signaling in human articular chondrocytes [abstract]. Collins JA, Poole L, Furdui C, Nelson K, Loeser R.. Osteoarthritis Cartilage. 2015;23(Suppl 2):A32-A33.

Cysteine-mediated redox regulation of cell signaling in chondrocytes stimulated with fibronectin fragments [abstract]. Wood ST, Long D, Reisz J, Yammani R, Burke E, Klomsiri C, Poole L, Furdui C, Loeser R.. Osteoarthritis Cartilage. 2015;23(Suppl 2):A65-A66.

Determining the molecular basis for differential hyperoxidation sensitivity in peroxiredoxin 1 & 2 [abstract]. Bolduc J, Reisz-Haines J, Nelson K, Furdui C, Lowther WT.. FASEB J. 2015;29(Suppl 1):895.10.

Chemical approaches to detect and analyze protein sulfenic acids. Furdui CM, Poole LB.. Mass Spectrom Rev. 2014;33(2):126-146.

Broad phenotypic changes associated with gain of radiation resistance in head and neck squamous cell cancer. Bansal N, Mims J, Kuremsky JG, Olex AL, Zhao W, Yin L, Wani R, Qian J, Center B, Marrs GS, Porosnicu M, Fetrow JS, Tsang AW, Furdui CM.. Antioxid Redox Signal. 2014;21(2):221-236.

Ionizing radiation: mechanisms and therapeutics [editorial]. Furdui CM.. Antioxid Redox Signal. 2014;21(2):218-220.

Activation of epidermal growth factor receptor is required for Chlamydia trachomatis development. Patel AL, Chen X, Wood ST, Stuart ES, Arcaro KF, Molina DP, Petrovic S, Furdui CM, Tsang AW.. BMC Microbiol. 2014;14(1):277.

Structural and functional studies of Akt2 oxidation and its implications in disease [abstract]. Lopez EIS, Tsang AW, Furdui CM.. Free Radic Biol Med. 2014;76(Suppl 1):S160.

Modulation of signaling proteins by reversible cysteine modification [abstract]. Keyes JD, Nelson K, Parsonage D, Daniel L, Furdui C, Poole L.. FASEB J. 2013;27():993.3.

Identification of an essential active-site residue in the alpha-D-phosphohexomutase enzyme superfamily. Lee Y, Mehra-Chaudhary R, Furdui C, Beamer LJ.. FEBS J. 2013;280(11):2622-2632.

Exogenous acid loads increase ROS production by the kidney [abstract]. Sun X, Reisz J, Molina DP, Nuradin N, Tay RR, Furdui CM, DuBose TD, Petrovic S.. J Am Soc Nephrol. 2013;24(Abstract Suppl):245A.

Thiol-blocking electrophiles interfere with labeling and detection of protein sulfenic acids. Reisz JA, Bechtold E, King SB, Poole LB, Furdui CM.. FEBS J. 2013;280(23):6150-6161.

Molecular basis for the resistance of human mitochondrial 2-Cys peroxiredoxin 3 to hyperoxidation. Haynes AC, Qian J, Reisz JA, Furdui CM, Lowther WT.. J Biol Chem. 2013;288(41):29714-23.

A simple and effective strategy for labeling cysteine sulfenic acid in proteins by utilization of beta-ketoesters as cleavable probes. Qian J, Wani R, Klomsiri C, Poole LB, Tsang AW, Furdui CM.. Chem Commun (Camb). 2012;48(34):4091-4093.

A coevolutionary residue network at the site of a functionally important conformational change in a phosphohexomutase enzyme family. Lee Y, Mick J, Furdui C, Beamer LJ.. PLoS ONE. 2012;7(6):e38114.

Myosin heavy chain isoform expression in the Vastus Lateralis muscle of aging African green vervet monkeys. Feng X, Zhang T, Xu Z, Choi SJ, Qian J, Furdui CM, Register TC, Delbono O.. Exp Gerontol. 2012;47(8):601-607.

Vascular bioactivation of nitroglycerin by aldehyde dehydrogenase-2: reaction intermediates revealed by crystallography and mass spectrometry. Lang BS, Gorren ACF, Oberdorfer G, Wenzl MV, Furdui CM, Poole LB, Mayer B, Gruber K.. J Biol Chem. 2012;287(45):38124-34.

Isoform-specific regulation of Akt by PDGF-induced reactive oxygen species. Wani R, Qian J, Yin L, Bechtold E, King SB, Poole LB, Paek E, Tsang AW, Furdui CM.. Proc Natl Acad Sci U S A. 2011;108(26):10550-5.

Simple synthesis of 1,3-cyclopentanedione derived probes for labeling sulfenic acid proteins. Qian J, Klomsiri C, Wright MW, King SB, Tsang AW, Poole LB, Furdui CM.. Chem Commun. 2011;47(32):9203-9205.

pH-dependent regulation of the alpha-subunit of H+-K+-ATPase (HKalpha2). Codina J, Opyd TS, Powell ZB, Furdui CM, Petrovic S, Penn RB, DuBose TD Jr.. Am J Physiol Renal Physiol. 2011;301(3):F536-F543.

Oxidation of Akt2 kinase promotes cell migration and regulates G 1-S transition in the cell cycle. Wani R, Bharathi NS, Field J, Tsang AW, Furdui CM.. Cell Cycle. 2011;10(19):3263-3268.

Simple synthesis of chemical probes for labeling sulfenic acid proteins [abstract]. Qian J, Klomsiri C, King SB, Poole LB, Tsang AW, Furdui CM.. Free Radic Biol Med. 2011;51(Suppl 1):S20.

Water-soluble triarylphosphines as biomarkers for protein S-nitrosation. Bechtold E, Reisz JA, Klomsiri C, Tsang AW, Wright MW, Poole LB, Furdui CM, King SB.. ACS Chem Biol. 2010;5(4):405-414.

Use of dimedone-based chemical probes for sulfenic acid detection evaluation of conditions affecting probe incorporation into redox-sensitive proteins. Klomsiri C, Nelson KJ, Bechtold E, Soito L, Johnson LC, Lowther WT, Ryu S-E, King SB, Furdui CM, Poole LB.. Methods Enzymol. 2010;473():77-94.

Breaking the covalent connection: chain connectivity and the catalytic reaction of PMM/PGM. Schramm AM, Karr D, Mehra-Chaudhary R, Van Doren SR, Furdui CM, Beamer LJ.. Protein Sci. 2010;19(6):1235-1242.

Observation of a chemically labile, noncovalent enzyme intermediate in the reaction of metal-dependent Aquifex pyrophilus KDO8PS by time-resolved mass spectrometry. Roberts A, Furdui C, Anderson KS.. Rapid Commun Mass Spectrom. 2010;24(13):1919-1924.

Characteristic and counting polynomials: modelling nonane isomers properties. Jantschi L, Bolboac SD, Furdui CM.. Mol Simul. 2009;35(3):220-227.

The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations. Lew ED, Furdui CM, Anderson KS, Schlessinger J.. Sci Signal. 2009;2(58):ra6.

Crystal structure and catalytic properties of Bacillus anthracis CoADR-RHD: implications for flavin-linked sulfur trafficking. Wallen JR, Mallett TC, Boles W, Parsonage D, Furdui CM, Karplus PA, Claiborne A.. Biochemistry. 2009;48(40):9650-9667.

Detection and identification of oxidative cysteine modifications in proteins involved in signal transduction pathways [abstract]. Klomsiri C, Poole LB, Nelson KJ, Rogers L, Klorig EB, Daniel LW, King SB, Furdui CM.. Free Radic Biol Med. 2009;47(Suppl 1):S17-S18.

The reaction of S-nitrosothiols with a water-soluble phosphine gives S-alkyl phosphonium products as potential bio-markers [abstract]. Klorig EB, Reisz JA, Klomsiri C, Wright MW, Day CS, Poole LB, Furdui CM, King B.. Free Radic Biol Med. 2009;47(Suppl 1):S32.

Identification of intact protein thiosulfinate intermediate in the reduction of cysteine sulfinic acid in peroxiredoxin by human sulfiredoxin. Jonsson TJ, Tsang AW, Lowther WT, Furdui CM.. J Biol Chem. 2008;283(34):22890-94.

Backbone flexibility, conformational change, and catalysis in a phosphohexomutase from Pseudomonas aeruginosa. Schramm AM, Mehra-Chaudhary R, Furdui CM, Beamer LJ.. Biochemistry. 2008;47(35):9154-9162.

Fluorescent and affinity-based tools to detect cysteine sulfenic acid formation in proteins. Poole LB, Klomsiri C, Knaggs SA, Furdui CM, Nelson KJ, Thomas MJ, Fetrow JS, Daniel LW, King SB.. Bioconjug Chem. 2007;18(6):2004-2017.

Cysteine sulfenic acid detection in signal transduction pathways [abstract]. Klomsiri C, Nelson KJ, Naggs SA, Fetrow JS, King SB, Furdui CM, Poole LB.. Free Radic Biol Med. 2007;43(Suppl 1):S157.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Molecular Medicine

Cristina Maria Furdui, Ph.D.

Cristina Maria Furdui, Ph.D.

Associate Professor, Molecular Medicine
Office of Women in Medicine and Science

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