Cristina Maria Furdui, Ph.D.Wake Forest School of Medicine

Cristina Maria Furdui, Ph.D.

Associate Professor,

Contact Information

Academic: 336-716-2697 | Department: 336-716-2011

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Education & Training

  • Ph.D., University of Nebraska-Lincoln, 2002
  • Fellowship, Yale University, 2004
Cristina Maria Furdui, Ph.D.

Cristina Maria Furdui, Ph.D.

Associate Professor, Molecular Medicine
Comprehensive Cancer Center

Research Interests

aging, arthritis, biotechnology, cancer/oncogenesis, environmental sciences, genomics and proteomics, hormones/cytokines/signalling, molecular biology/molecular me, metabolism, drugs/therapeutic agents pharm

Contact Information

Academic: 336-716-2697 | Department: 336-716-2011

Related Links

Recent Publications

Devarie-Baez NO, Silva Lopez E, Furdui CM. Biological chemistry and functionality of protein sulfenic acids and related thiol modifications. Free Radic Res. 2016;50(2):172-194.

Wood ST, Long DL, Reisz JA, Yammani RR, Burke EA, Klomsiri C, Poole LB, Furdui CM, Loeser RF. Cysteine-mediated redox regulation of cell signaling in chondrocytes stimulated with fibronectin fragments. Arthritis Rheumatol. 2016;68(1):117-126.

Ritchie MK, Johnson LC, Clodfelter JE, Pemble CW IV, Fulp BE, Furdui CM, Kridel SJ, Lowther WT. Crystal structure and substrate specificity of human thioesterase 2: insights into the molecular basis for the modulation of fatty acid synthase. J Biol Chem. 2016;291(7):3520-3530.

Weckerle A, Snipes JA, Cheng D, Gebre AK, Reisz JA, Murea M, Shelness GS, Hawkins GA, Furdui CM, Freedman BI, Parks JS, Ma L. Characterization of circulating APOL1 protein complexes in African Americans. J Lipid Res. 2016;57(1):120-130.

Collins JA, Wood ST, Nelson KJ, Rowe MA, Carlson CS, Chubinskaya S, Poole LB, Furdui CM, Loeser RF. Oxidative stress promotes peroxiredoxin hyperoxidation and attenuates pro-survival signalling in aging chondrocytes. J Biol Chem. 2016;291(13):6641-6654.

Zhang T, Pereyra AS, Wang ZM, Birbrair A, Reisz JA, Files DC, Purcell L, Feng X, Messi ML, Feng H, Chalovich J, Jin JP, Furdui C, Delbono O. Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice. Aging Cell. 2016;15(3):488-498.

Wajih N, Liu X, Shetty P, Basu S, Wu H, Hogg N, Patel RP, Furdui CM, Kim-Shapiro DB. The role of red blood cell S-nitrosation in nitrite bioactivation and its modulation by leucine and glucose. Redox Biol. 2016;8():415-421.

Devarie Baez NO, Reisz JA, Furdui CM. Mass spectrometry in studies of protein thiol chemistry and signaling: opportunities and caveats. Free Radic Biol Med. 2015;80():191-211.

Parsonage D, Nelson KJ, Ferrer-Sueta G, Alley S, Karplus PA, Furdui CM, Poole LB. Dissecting peroxiredoxin catalysis: separating binding, peroxidation, and resolution for a bacterial AhpC. Biochemistry. 2015;54(7):1567-1575.

Mims J, Bansal N, Bharadwaj MS, Chen X, Molina AJ, Tsang AW, Furdui CM. Energy metabolism in a matched model of radiation resistance for head and neck squamous cell cancer. Radiat Res. 2015;183(3):291-304.

Chen X, Liu L, Mims J, Punska EC, Williams KE, Zhao W, Arcaro KF, Tsang AW, Zhou X, Furdui CM. Analysis of DNA methylation and gene expression in radiation-resistant head and neck tumors. Epigenetics. 2015;10(6):545-561.

Swanner J, Mims J, Carroll DL, Akman SA, Furdui CM, Torti SV, Singh RN. Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells. Int J Nanomedicine. 2015;10():3937-3953.

Collins JA, Poole L, Furdui C, Nelson K, Loeser R. Mitochondrial reactive oxygen species (ROS) promote hyperoxidation of peroxiredoxins and inhibit pro-survival IGF-1 signaling in human articular chondrocytes [abstract]. Osteoarthritis Cartilage. 2015;23(Suppl 2):A32-A33.

Wood ST, Long D, Reisz J, Yammani R, Burke E, Klomsiri C, Poole L, Furdui C, Loeser R. Cysteine-mediated redox regulation of cell signaling in chondrocytes stimulated with fibronectin fragments [abstract]. Osteoarthritis Cartilage. 2015;23(Suppl 2):A65-A66.

Bolduc J, Reisz-Haines J, Nelson K, Furdui C, Lowther WT. Determining the molecular basis for differential hyperoxidation sensitivity in peroxiredoxin 1 & 2 [abstract]. FASEB J. 2015;29(Suppl 1):895.10.

Peloso A, Urbani L, Cravedi P, Katari R, Maghsoudlou P, Fallas ME, Sordi V, Citro A, Purroy C, Niu G, McQuilling JP, Sittadjody S, Farney AC, Iskandar SS, Zambon JP, Rogers J, Stratta RJ, Opara EC, Piemonti L, Furdui CM, Soker S, De Coppi P, Orlando G. The human pancreas as a source of protolerogenic extracellular matrix scaffold for a new-generation bioartificial endocrine pancreas. Ann Surg. 2015;():.

Furdui CM, Poole LB. Chemical approaches to detect and analyze protein sulfenic acids. Mass Spectrom Rev. 2014;33(2):126-146.

Bansal N, Mims J, Kuremsky JG, Olex AL, Zhao W, Yin L, Wani R, Qian J, Center B, Marrs GS, Porosnicu M, Fetrow JS, Tsang AW, Furdui CM. Broad phenotypic changes associated with gain of radiation resistance in head and neck squamous cell cancer. Antioxid Redox Signal. 2014;21(2):221-236.

Furdui CM. Ionizing radiation: mechanisms and therapeutics [editorial]. Antioxid Redox Signal. 2014;21(2):218-220.

Patel AL, Chen X, Wood ST, Stuart ES, Arcaro KF, Molina DP, Petrovic S, Furdui CM, Tsang AW. Activation of epidermal growth factor receptor is required for Chlamydia trachomatis development. BMC Microbiol. 2014;14(1):277.

Lopez EIS, Tsang AW, Furdui CM. Structural and functional studies of Akt2 oxidation and its implications in disease [abstract]. Free Radic Biol Med. 2014;76(Suppl 1):S160.

Keyes JD, Nelson K, Parsonage D, Daniel L, Furdui C, Poole L. Modulation of signaling proteins by reversible cysteine modification [abstract]. FASEB J. 2013;27():993.3.

Lee Y, Mehra-Chaudhary R, Furdui C, Beamer LJ. Identification of an essential active-site residue in the alpha-D-phosphohexomutase enzyme superfamily. FEBS J. 2013;280(11):2622-2632.

Sun X, Reisz J, Molina DP, Nuradin N, Tay RR, Furdui CM, DuBose TD, Petrovic S. Exogenous acid loads increase ROS production by the kidney [abstract]. J Am Soc Nephrol. 2013;24(Abstract Suppl):245A.

Reisz JA, Bechtold E, King SB, Poole LB, Furdui CM. Thiol-blocking electrophiles interfere with labeling and detection of protein sulfenic acids. FEBS J. 2013;280(23):6150-6161.

Haynes AC, Qian J, Reisz JA, Furdui CM, Lowther WT. Molecular basis for the resistance of human mitochondrial 2-Cys peroxiredoxin 3 to hyperoxidation. J Biol Chem. 2013;288(41):29714-23.

Qian J, Wani R, Klomsiri C, Poole LB, Tsang AW, Furdui CM. A simple and effective strategy for labeling cysteine sulfenic acid in proteins by utilization of beta-ketoesters as cleavable probes. Chem Commun (Camb). 2012;48(34):4091-4093.

Lee Y, Mick J, Furdui C, Beamer LJ. A coevolutionary residue network at the site of a functionally important conformational change in a phosphohexomutase enzyme family. PLoS ONE. 2012;7(6):e38114.

Feng X, Zhang T, Xu Z, Choi SJ, Qian J, Furdui CM, Register TC, Delbono O. Myosin heavy chain isoform expression in the Vastus Lateralis muscle of aging African green vervet monkeys. Exp Gerontol. 2012;47(8):601-607.

Lang BS, Gorren ACF, Oberdorfer G, Wenzl MV, Furdui CM, Poole LB, Mayer B, Gruber K. Vascular bioactivation of nitroglycerin by aldehyde dehydrogenase-2: reaction intermediates revealed by crystallography and mass spectrometry. J Biol Chem. 2012;287(45):38124-34.

Wani R, Qian J, Yin L, Bechtold E, King SB, Poole LB, Paek E, Tsang AW, Furdui CM. Isoform-specific regulation of Akt by PDGF-induced reactive oxygen species. Proc Natl Acad Sci U S A. 2011;108(26):10550-5.

Qian J, Klomsiri C, Wright MW, King SB, Tsang AW, Poole LB, Furdui CM. Simple synthesis of 1,3-cyclopentanedione derived probes for labeling sulfenic acid proteins. Chem Commun. 2011;47(32):9203-9205.

Codina J, Opyd TS, Powell ZB, Furdui CM, Petrovic S, Penn RB, DuBose TD Jr. pH-dependent regulation of the alpha-subunit of H+-K+-ATPase (HKalpha2). Am J Physiol Renal Physiol. 2011;301(3):F536-F543.

Wani R, Bharathi NS, Field J, Tsang AW, Furdui CM. Oxidation of Akt2 kinase promotes cell migration and regulates G 1-S transition in the cell cycle. Cell Cycle. 2011;10(19):3263-3268.

Qian J, Klomsiri C, King SB, Poole LB, Tsang AW, Furdui CM. Simple synthesis of chemical probes for labeling sulfenic acid proteins [abstract]. Free Radic Biol Med. 2011;51(Suppl 1):S20.

Bechtold E, Reisz JA, Klomsiri C, Tsang AW, Wright MW, Poole LB, Furdui CM, King SB. Water-soluble triarylphosphines as biomarkers for protein S-nitrosation. ACS Chem Biol. 2010;5(4):405-414.

Klomsiri C, Nelson KJ, Bechtold E, Soito L, Johnson LC, Lowther WT, Ryu S-E, King SB, Furdui CM, Poole LB. Use of dimedone-based chemical probes for sulfenic acid detection evaluation of conditions affecting probe incorporation into redox-sensitive proteins. Methods Enzymol. 2010;473():77-94.

Schramm AM, Karr D, Mehra-Chaudhary R, Van Doren SR, Furdui CM, Beamer LJ. Breaking the covalent connection: chain connectivity and the catalytic reaction of PMM/PGM. Protein Sci. 2010;19(6):1235-1242.

Roberts A, Furdui C, Anderson KS. Observation of a chemically labile, noncovalent enzyme intermediate in the reaction of metal-dependent Aquifex pyrophilus KDO8PS by time-resolved mass spectrometry. Rapid Commun Mass Spectrom. 2010;24(13):1919-1924.

Jantschi L, Bolboac SD, Furdui CM. Characteristic and counting polynomials: modelling nonane isomers properties. Mol Simul. 2009;35(3):220-227.

Lew ED, Furdui CM, Anderson KS, Schlessinger J. The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations. Sci Signal. 2009;2(58):ra6.

Wallen JR, Mallett TC, Boles W, Parsonage D, Furdui CM, Karplus PA, Claiborne A. Crystal structure and catalytic properties of Bacillus anthracis CoADR-RHD: implications for flavin-linked sulfur trafficking. Biochemistry. 2009;48(40):9650-9667.

Klomsiri C, Poole LB, Nelson KJ, Rogers L, Klorig EB, Daniel LW, King SB, Furdui CM. Detection and identification of oxidative cysteine modifications in proteins involved in signal transduction pathways [abstract]. Free Radic Biol Med. 2009;47(Suppl 1):S17-S18.

Klorig EB, Reisz JA, Klomsiri C, Wright MW, Day CS, Poole LB, Furdui CM, King B. The reaction of S-nitrosothiols with a water-soluble phosphine gives S-alkyl phosphonium products as potential bio-markers [abstract]. Free Radic Biol Med. 2009;47(Suppl 1):S32.

Jonsson TJ, Tsang AW, Lowther WT, Furdui CM. Identification of intact protein thiosulfinate intermediate in the reduction of cysteine sulfinic acid in peroxiredoxin by human sulfiredoxin. J Biol Chem. 2008;283(34):22890-94.

Schramm AM, Mehra-Chaudhary R, Furdui CM, Beamer LJ. Backbone flexibility, conformational change, and catalysis in a phosphohexomutase from Pseudomonas aeruginosa. Biochemistry. 2008;47(35):9154-9162.

Poole LB, Klomsiri C, Knaggs SA, Furdui CM, Nelson KJ, Thomas MJ, Fetrow JS, Daniel LW, King SB. Fluorescent and affinity-based tools to detect cysteine sulfenic acid formation in proteins. Bioconjug Chem. 2007;18(6):2004-2017.

Klomsiri C, Nelson KJ, Naggs SA, Fetrow JS, King SB, Furdui CM, Poole LB. Cysteine sulfenic acid detection in signal transduction pathways [abstract]. Free Radic Biol Med. 2007;43(Suppl 1):S157.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Molecular Medicine

Cristina Maria Furdui, Ph.D.

Cristina Maria Furdui, Ph.D.

Associate Professor, Molecular Medicine
Comprehensive Cancer Center

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