Cristina Maria Furdui, Ph.D.Wake Forest School of Medicine

Cristina Maria Furdui, Ph.D.

Associate Professor,

Contact Information

Academic: 336-716-2697 | Department: 336-716-2011

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Education & Training

  • Ph.D., University of Nebraska-Lincoln , 2002
  • Fellowship, Yale University, 2004
Cristina Maria Furdui, Ph.D.

Cristina Maria Furdui, Ph.D.

Associate Professor, Molecular Medicine
Comprehensive Cancer Center
Translational Science Institute
Cancer Biology

Research Interests

aging, arthritis, biotechnology, cancer/oncogenesis, environmental sciences, fitness/physical, genomics and proteomics, hormones/cytokines/signalling, molecular biology/molecular me

Contact Information

Academic: 336-716-2697 | Department: 336-716-2011

Related Links

Recent Publications

Devarie Baez NO, Reisz JA, Furdui CM. Mass spectrometry in studies of protein thiol chemistry and signaling: opportunities and caveats. Free Radic Biol Med. 2015;80():191-211.

Furdui CM, Poole LB. Chemical approaches to detect and analyze protein sulfenic acids. Mass Spectrom Rev. 2014;33(2):126-146.

Bansal N, Mims J, Kuremsky JG, Olex AL, Zhao W, Yin L, Wani R, Qian J, Center B, Marrs GS, Porosnicu M, Fetrow JS, Tsang AW, Furdui CM. Broad phenotypic changes associated with gain of radiation resistance in head and neck squamous cell cancer. Antioxid Redox Signal. 2014;21(2):221-236.

Furdui CM. Ionizing radiation: mechanisms and therapeutics [editorial]. Antioxid Redox Signal. 2014;21(2):218-220.

Patel AL, Chen X, Wood ST, Stuart ES, Arcaro KF, Molina DP, Petrovic S, Furdui CM, Tsang AW. Activation of epidermal growth factor receptor is required for Chlamydia trachomatis development. BMC Microbiol. 2014;14(1):277.

Keyes JD, Nelson K, Parsonage D, Daniel L, Furdui C, Poole L. Modulation of signaling proteins by reversible cysteine modification [abstract]. FASEB J. 2013;27():993.3.

Lee Y, Mehra-Chaudhary R, Furdui C, Beamer LJ. Identification of an essential active-site residue in the alpha-D-phosphohexomutase enzyme superfamily. FEBS J. 2013;280(11):2622-2632.

Sun X, Reisz J, Molina DP, Nuradin N, Tay RR, Furdui CM, DuBose TD, Petrovic S. Exogenous acid loads increase ROS production by the kidney [abstract]. J Am Soc Nephrol. 2013;24(Abstract Suppl):245A.

Reisz JA, Bechtold E, King SB, Poole LB, Furdui CM. Thiol-blocking electrophiles interfere with labeling and detection of protein sulfenic acids. FEBS J. 2013;280(23):6150-6161.

Haynes AC, Qian J, Reisz JA, Furdui CM, Lowther WT. Molecular basis for the resistance of human mitochondrial 2-Cys peroxiredoxin 3 to hyperoxidation. J Biol Chem. 2013;288(41):29714-23.

Qian J, Wani R, Klomsiri C, Poole LB, Tsang AW, Furdui CM. A simple and effective strategy for labeling cysteine sulfenic acid in proteins by utilization of beta-ketoesters as cleavable probes. Chem Commun (Camb). 2012;48(34):4091-4093.

Feng X, Zhang T, Xu Z, Choi SJ, Qian J, Furdui CM, Register TC, Delbono O. Myosin heavy chain isoform expression in the Vastus Lateralis muscle of aging African green vervet monkeys. Exp Gerontol. 2012;47(8):601-607.

Lang BS, Gorren ACF, Oberdorfer G, Wenzl MV, Furdui CM, Poole LB, Mayer B, Gruber K. Vascular bioactivation of nitroglycerin by aldehyde dehydrogenase-2: reaction intermediates revealed by crystallography and mass spectrometry. J Biol Chem. 2012;287(45):38124-34.

Wani R, Qian J, Yin L, Bechtold E, King SB, Poole LB, Paek E, Tsang AW, Furdui CM. Isoform-specific regulation of Akt by PDGF-induced reactive oxygen species. Proc Natl Acad Sci U S A. 2011;108(26):10550-5.

Qian J, Klomsiri C, Wright MW, King SB, Tsang AW, Poole LB, Furdui CM. Simple synthesis of 1,3-cyclopentanedione derived probes for labeling sulfenic acid proteins. Chem Commun. 2011;47(32):9203-9205.

Codina J, Opyd TS, Powell ZB, Furdui CM, Petrovic S, Penn RB, DuBose TD Jr. pH-dependent regulation of the alpha-subunit of H+-K+-ATPase (HKalpha2). Am J Physiol Renal Physiol. 2011;301(3):F536-F543.

Wani R, Bharathi NS, Field J, Tsang AW, Furdui CM. Oxidation of Akt2 kinase promotes cell migration and regulates G 1-S transition in the cell cycle. Cell Cycle. 2011;10(19):3263-3268.

Qian J, Klomsiri C, King SB, Poole LB, Tsang AW, Furdui CM. Simple synthesis of chemical probes for labeling sulfenic acid proteins [abstract]. Free Radic Biol Med. 2011;51(Suppl 1):S20.

Bechtold E, Reisz JA, Klomsiri C, Tsang AW, Wright MW, Poole LB, Furdui CM, King SB. Water-soluble triarylphosphines as biomarkers for protein S-nitrosation. ACS Chem Biol. 2010;5(4):405-414.

Klomsiri C, Nelson KJ, Bechtold E, Soito L, Johnson LC, Lowther WT, Ryu S-E, King SB, Furdui CM, Poole LB. Use of dimedone-based chemical probes for sulfenic acid detection evaluation of conditions affecting probe incorporation into redox-sensitive proteins. Methods Enzymol. 2010;473():77-94.

Schramm AM, Karr D, Mehra-Chaudhary R, Van Doren SR, Furdui CM, Beamer LJ. Breaking the covalent connection: chain connectivity and the catalytic reaction of PMM/PGM. Protein Sci. 2010;19(6):1235-1242.

Jantschi L, Bolboac SD, Furdui CM. Characteristic and counting polynomials: modelling nonane isomers properties. Mol Simul. 2009;35(3):220-227.

Lew ED, Furdui CM, Anderson KS, Schlessinger J. The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations. Sci Signal. 2009;2(58):ra6.

Wallen JR, Mallett TC, Boles W, Parsonage D, Furdui CM, Karplus PA, Claiborne A. Crystal structure and catalytic properties of Bacillus anthracis CoADR-RHD: implications for flavin-linked sulfur trafficking. Biochemistry. 2009;48(40):9650-9667.

Klomsiri C, Poole LB, Nelson KJ, Rogers L, Klorig EB, Daniel LW, King SB, Furdui CM. Detection and identification of oxidative cysteine modifications in proteins involved in signal transduction pathways [abstract]. Free Radic Biol Med. 2009;47(Suppl 1):S17-S18.

Klorig EB, Reisz JA, Klomsiri C, Wright MW, Day CS, Poole LB, Furdui CM, King B. The reaction of S-nitrosothiols with a water-soluble phosphine gives S-alkyl phosphonium products as potential bio-markers [abstract]. Free Radic Biol Med. 2009;47(Suppl 1):S32.

Schramm AM, Mehra-Chaudhary R, Furdui CM, Beamer LJ. Backbone flexibility, conformational change, and catalysis in a phosphohexomutase from Pseudomonas aeruginosa. Biochemistry. 2008;47(35):9154-9162.

Poole LB, Klomsiri C, Knaggs SA, Furdui CM, Nelson KJ, Thomas MJ, Fetrow JS, Daniel LW, King SB. Fluorescent and affinity-based tools to detect cysteine sulfenic acid formation in proteins. Bioconjug Chem. 2007;18(6):2004-2017.

Klomsiri C, Nelson KJ, Naggs SA, Fetrow JS, King SB, Furdui CM, Poole LB. Cysteine sulfenic acid detection in signal transduction pathways [abstract]. Free Radic Biol Med. 2007;43(Suppl 1):S157.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Molecular Medicine

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