Profile

Patricia E. Gallagher, Ph.D.Wake Forest School of Medicine

Patricia E. Gallagher, Ph.D.

Professor,
Redox Biology & Medicine Ctr

Contact Information

Academic: 336-716-4455 | Department: 336-716-4455

Email: pgallagh@wakehealth.edu

Education & Training

  • B.S., University of Memphis, 1972
  • Ph.D., University of Tennessee-Memphis, 1983
  • Fellowship, Temple University School of Me, 1986

Memberships

  • Am Soc Biochem Molecular Bio
  • Am Soc of Cancer Research
  • Fed Of Am Soc For Experimental
Patricia E. Gallagher, Ph.D.

Patricia E. Gallagher, Ph.D.

Professor, Hypertension
Redox Biology & Medicine Ctr

Research Interests

Peptide Fragments; Angiotensin I; Peptidyl-Dipeptidase A; Angiotensin II; Renin-Angiotensin System
More »

Contact Information

Academic: 336-716-4455 | Department: 336-716-4455

Email: pgallagh@wakehealth.edu

Recent Publications

Angiotensin-(1-7) attenuates skeletal muscle fibrosis and stiffening in a mouse model of extremity sarcoma radiation therapy. Willey JS, Bracey DN, Gallagher PE, Tallant EA, Wiggins WF, Callahan MF, Smith TL, Emory CL.. J Bone Joint Surg Am. 2016;98(1):48-55.

Biological screening of angiotensin-(1-7) analogues incorporating the non-natural delta-amino acid ACCA [abstract]. Wester A, O'Reilly E, Devocelle M, Gallagher PE, Paradisi F.. Amino Acids. 2016;48(2):636.

Medullary endocannabinoids contribute to the differential resting baroreflex sensitivity in rats with altered brain renin-angiotensin system expression. Schaich CL, Grabenauer M, Thomas BF, Shaltout HA, Gallagher PE, Howlett AC, Diz DI.. Front Physiol. 2016;7():207.

Beneficial cardiovascular effects of muscadine grape extract in normotensive female rats [abstract]. Duncan AV, Shaltout HA, Tommasi EN, Gallagher PE, Tallant EA, Diz DI.. FASEB J. 2016;30(1 Suppl):1175.7.

Local uterine Ang-(1-7) infusion augments the expression of cannabinoid receptors and differentially alters endocannabinoid metabolizing enzymes in the decidualized uterus of pseudopregnant rats. Brosnihan KB, Pulgar VM, Gallagher PE, Neves LA, Yamaleyeva LM.. Reprod Biol Endocrinol. 2015;13(1):5.

Angiotensin-(1-7) prevents angiotensin II-induced fibrosis in cremaster microvessels. Carver KA, Smith TL, Gallagher PE, Tallant EA.. Microcirculation. 2015;22(1):19-27.

Alterations in the medullary endocannabinoid system contribute to age-related impairment of baroreflex sensitivity. Schaich CL, Shaltout HA, Grabenauer M, Thomas BF, Gallagher PE, Howlett AC, Diz DI.. J Cardiovasc Pharmacol. 2015;65(5):473-479.

Downregulation of apelin in the human placental chorionic villi from preeclamptic pregnancies. Yamaleyeva LM, Chappell MC, Brosnihan KB, Anton L, Caudell DL, Shi S, McGee C, Pirro N, Gallagher PE, Taylor RN, Merrill DC, Mertz HL.. Am J Physiol Endocrinol Metab. 2015;309(10):E852-E860.

Angiotensin-(1-7) targets c-Met signaling by up-regulating the phosphatase PTP1b to reduce triple negative breast cancer [abstract]. Deng G, Metheny-Barlow L, Gallagher PE, Tallant EA.. Cancer Res. 2015;75(15 Suppl):4981.

Prevention of breast tumor growth by an extract from the muscadine grape [abstract]. Gallagher PE, Tallant EA.. Cancer Res. 2015;75(15 Suppl):2825.

Muscadine grape extract reduces lung carcinogenesis in female mice exposed to 3-methylcholanthrene in utero [abstract]. Porter BE, Moore JE, Miller MS, Tallant EA, Gallagher PE.. Cancer Res. 2015;75(15 Suppl):4563.

Angiotensin-(1-7) prevents fibrosis in doxorubicin-treated rats [abstract]. Rahimi OA, Castellino SM, Cammock CE, Tallant EA, Gallagher PE.. Cancer Res. 2015;75(15 Suppl):4489.

Angiotensin-(1-7): a peptide hormone with anti-cancer activity. Gallagher PE, Arter AL, Deng G, Tallant AE.. Curr Med Chem. 2014;21(21):2417-2423.

The endogenous peptide angiotensin-(1-7) prevents radiation-induced muscle fibrosis: an in vivo murine model [abstract]. Bracey DN, Willey JS, Tallant EA, Gallagher PE, Wiggins WF, Callahan MF, Smith TL, Emory CL.. In: Proceedings of the 2014 Annual Meeting of the American Academy of Orthopaedic Surgeons; 2014 March 15-18; New Orleans (LA). 2014;():.

Opposing interactions between angiotensin II and apelin in human placental chorionic villi [abstract]. Yamaleyeva LM, Brosnihan KB, Anton L, McGee C, Mertz HL, Gallagher PE, Merrill DC.. Reprod Sci. 2014;21(3 Suppl):393A.

Blockade of angiotensin-(1-7)-mediated vascular remodeling by a CB2 cannabinoid receptor antagonist [abstract]. Tallant EA, Howlett AC, Gallagher PE.. Hypertension. 2014;64(Suppl 1):A542.

Increased uterine interimplantation levels of Ang II, AT1R, and CB1R are associated with reduced uterine permeability at early pregnancy in a transgenic model of preeclampsia [abstract]. Brosnihan KB, Pulgar VM, Varagic J, Oliva K, Bader M, Delbruck M, Dechend R, Gallagher P, Thomas BF, Grabenauer M, Yamaleyeva LM.. Hypertension. 2014;64(Suppl 1):A577.

Angiotensin-(1-7) attenuates triple negative breast cancer progression bytargeting C-Met and downstream ERK1/2 signaling [abstract]. Deng G, Tallant EA, Gallagher P.. Mol Cancer Res. 2014;12(Suppl 12):A30.

Angiotensin-(1-7) attenuates metastatic prostate cancer and reduces osteoclastogenesis. Krishnan B, Smith TL, Dubey P, Zapadka ME, Torti FM, Willingham MC, Tallant EA, Gallagher PE.. Prostate. 2013;73(1):71-82.

Brain renin-angiotensin system in the nexus of hypertension and aging. Arnold AC, Gallagher PE, Diz DI.. Hypertens Res. 2013;36(1):5-13.

Angiotensin-(1-7) reduces proliferation and angiogenesis of human prostate cancer xenografts with a decrease in angiogenic factors and an increase in sFlt-1. Krishnan B, Torti FM, Gallagher PE, Tallant EA.. Prostate. 2013;73(1):60-70.

AT1, AT2, and AT1-7 receptor expression in the uteroplacental unit of normotensive and hypertensive rats during early and late pregnancy. Yamaleyeva LM, Neves LA, Coveleskie K, Diz DI, Gallagher PE, Brosnihan KB.. Placenta. 2013;34(6):497-502.

Angiotensin II/angiotensin-(1-7). Gallagher PE, Arter AL, Krishnan B, Garcia-Espinosa MA, Tallant EA. In: Kastin AJ, ed. Handbook of biologically acive peptides. 2nd ed. Oxford: Academic Press;2013: 494-501.

Tissue specific regulation of CB1/CB2 gene receptors in salt sensitive hypertension of SHR [abstract]. Varagic J, Gallagher PE.. FASEB J. 2013;27():1108.8.

The endogenous peptide angiotensin-(1-7) prevents radiation-induced muscle fibrosis: an in vivo murine model [abstract]. Bracey D, Willey JS, Tallant EA, Gallagher PD [sic] [Gallagher PE], Smith TL, Callahan MF, Emory CL.. Int J Radiat Oncol Biol Phys. 2013;87(2 Suppl):S167.

Angiotensin-(1-7) prevents radiation-induced inflammation in rat primary astrocytes through regulation of MAP kinase signaling. Moore ED, Kooshki M, Metheny-Barlow LJ, Gallagher PE, Robbins ME [deceased].. Free Radic Biol Med. 2013;65():1060-1068.

The CB2 cannabinoid receptor mediates the anti-proliferative actions of angiotensin-(1-7) in vascular smooth muscle cells [abstract]. Tallant EA, Howlett A, Grabenauer M, Thomas BF, Gallagher PE.. Hypertension. 2013;62(3 Suppl):465.

Local uterine Ang-(1-7) infusion augments expression of cannabinoid receptors and differentially alters endocannabinoid metabolizing enzymes in the decidualized uterus of pseudopregnant rats [abstract]. Brosnihan KB, Yamaleyeva LM, Gallagher PE, Pulgar VM, Neves LA.. Hypertension. 2013;62(3 Suppl):543.

Renal endocannabinoids in salt-sensitive hypertension of SHR [abstract]. Varagic J, Gallagher PE, Grabenauer M, Thomas BF.. Hypertension. 2013;62(3 Suppl):499.

Angiotensin-(1-7) prevents radiation-induced muscle fibosis: an in vivo murine model [abstract]. Bracey DN, Willey JS, Tallant EA, Gallagher PE, Smith TL, Callahan MF, Emory CL.. In: Proceedings of the 2013 Annual Meeting of the Southern Orthopedic Association; 2013 July 30-August 2; Palm Beach (FL). 2013;():.

Local uterine Ang-(1-7) infusion augments the expression of CB1R, CB2 receptor and MAGL but not FAAH in the decidualized uterus of pseudopregnant rats [abstract]. Brosnihan KB, Yamaleyeva L, Gallagher PE, Pulgar V, Neves LAA.. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

The CB2cannabinoid receptor mediates the anti-proliferative actions of angiotensin-(1-7) in vascular smooth muscle cells [abstract]. Tallant EA, Howlett A, Grabenauer M, Thomas BF, Gallagher PE.. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

Cardiac and renal endocannabinoids in salt-loaded SHR [abstract]. Varagic J, Gallagher PE, Grabenauer M, Thomas BF.. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

Angiotensin-(1-7) attenuates the proliferation of cancer-associated fibroblasts in triple negative breast cancer [abstract]. Arter AL, Gallagher PE, Tallant EA.. Cancer Res. 2013;73(3 Suppl):B34.

Angiotensin-(1-7) suppresses lung metastasis in the 4T1 orthotopic mammary carcinoma model [abstract]. Arter A, Gallagher PE, Tallant AE [sic] [Tallant EA].. In: Proceedings of the 2013 International Conference on Tumor Microenvironment and Cellular Stress; 2013 Sept 27-Oct 2; Corfu (Greece). 2013;():.

Angiotensin-(1-7) attenuates angiotensin II-induced cardiac remodeling associated with upregulation of dual-specificity phosphatase 1. McCollum LT, Gallagher PE, Tallant EA.. Am J Physiol Heart Circ Physiol. 2012;302(3):H801-H810.

Angiotensin-(1-7) abrogates mitogen-stimulated proliferation of cardiac fibroblasts. McCollum LT, Gallagher PE, Tallant EA.. Peptides. 2012;34(2):380-388.

Amelioration of renal injury and oxidative stress by the nNOS inhibitor L-VNIO in the salt-sensitive mRen2.Lewis congenic rat. Yamaleyeva LM, Lindsey SH, Varagic J, Zhang LL, Gallagher PE, Chen AF, Chappell MC.. J Cardiovasc Pharmacol. 2012;59(6):529-538.

Angiotensin-(1-7), a peptide hormone with therapeutic potential for the treatment of glioblastomas [abstract]. Garcia-Espinosa MA, Lesser GJ, Debinski W, Tallant EA, Gallagher PE.. In: Proceedings of the 103rd Annual Meeting of the Amerian Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, Illinois. Philadelphia (PA): AACR. 2012;():Abstr 1938.

Angiotensin-(1-7) inhibits proliferative and fibrotic signaling mechanisms in triple negative breast cancer [abstract]. Arter AA, Metheny-Barlow L, Gallagher PE, Tallant EA.. In: Proceedings of the 103rd Annual Meeting of the Amerian Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, Illinois. Philadelphia (PA): AACR. 2012;():Abstr 5224.

In vivo expression of angiotensin-(1-7) lowers blood pressure and improves baroreflex function in transgenic (mRen2)27 rats. Garcia-Espinosa MA, Shaltout HA, Gallagher PE, Chappell MC, Diz DI.. J Cardiovasc Pharmacol. 2012;60(2):150-157.

Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded spontaneously hypertensive rats. Varagic J, Ahmad S, Voncannon JL, Moniwa N, Simington SW Jr, Brosnihan BK, Gallagher PE, Habibi J, Sowers JR, Ferrario CM.. J Hypertens. 2012;30(9):1766-1774.

Differences in oxidative stress status and expression of MKP-1 in dorsal medulla of transgenic rats with altered brain renin-angiotensin system. Nautiyal M, Katakam PV, Busija DW, Gallagher PE, Tallant EA, Chappell MC, Diz DI.. Am J Physiol Regul Integr Comp Physiol. 2012;303(8):R799-806.

Vascular remodeling by angiotensin peptide hormones alters reactivity of the microcirculation [abstract]. Carver KA, Smith TL, Gallagher PE, Tallant EA.. Hypertension. 2012;60(3 Suppl):530.

Angiotensin-(1-7) attenuates PDGF-dependent migration of vascular smooth muscle cells [abstract]. Tallant EA, Carver KA, Gallagher PE.. Hypertension. 2012;60(3 Suppl):512.

Angiotensin-(1-7) inhibits the growth of human pediatric rhabdomyosarcoma in a mouse xenograft model [abstract]. Gallagher PE, Maglic D, Krishnan B, Castellino SM, Tallant EA.. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando (FL). Philadelphia (PA): AACR. 2011;():Abstr 5349.

Angiotensin peptides and lung cancer. Gallagher PE, Cook K, Soto-Pantoja D, Menon J, Tallant EA.. Curr Cancer Drug Targets. 2011;11(4):394-404.

Long-term systemic angiotensin II type 1 receptor blockade regulates mRNA expression of dorsomedial medulla renin-angiotensin system components. Gilliam-Davis S, Gallagher PE, Payne VS, Kasper SO, Tommasi EN, Westwood BM, Robbins ME, Chappell MC, Diz DI.. Physiol Genomics. 2011;43(13):829-835.

Estrogen receptor GPR30 reduces oxidative stress and proteinuria in the salt-sensitive female mRen2.Lewis rat. Lindsey SH, Yamaleyeva LM, Brosnihan KB, Gallagher PE, Chappell MC.. Hypertension. 2011;58(4):665-671.

Angiotensin-(1-7) attenuates angiotensin II-induced fibrosis through a reduction in connective tissue growth factor [abstract]. Carver KA, Smith TL, Gallagher PE, Tallant EA.. Hypertension. 2011;58(5):e178.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Hypertension

Patricia E. Gallagher, Ph.D.

Patricia E. Gallagher, Ph.D.

Professor, Hypertension
Redox Biology & Medicine Ctr

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