Profile

Patricia E. Gallagher, Ph.D.Wake Forest School of Medicine

Patricia E. Gallagher, Ph.D.

Professor,


Contact Information

Academic: 336-716-4455 | Department: 336-716-4455

Email: pgallagh@wakehealth.edu

Education & Training

  • B.S., University of Memphis, 1972
  • Ph.D., University of Tennessee-Memphis, 1983
  • Fellowship, Temple University School of Me, 1986

Memberships

  • Am Soc Biochem Molecular Bio
  • Am Soc of Cancer Research
  • Fed Of Am Soc For Experimental
Patricia E. Gallagher, Ph.D.

Patricia E. Gallagher, Ph.D.

Professor, Hypertension
Comprehensive Cancer Center
Hypertension and Vascular Research Center

Research Interests

alternative medicine, cancer/oncogenesis, cardiac function, cell growth, differentiation,d, drugs/therapeutic agents pharm, growth & development, prevention

Contact Information

Academic: 336-716-4455 | Department: 336-716-4455

Email: pgallagh@wakehealth.edu

Recent Publications

Brosnihan KB, Pulgar VM, Gallagher PE, Neves LA, Yamaleyeva LM. Local uterine Ang-(1-7) infusion augments the expression of cannabinoid receptors and differentially alters endocannabinoid metabolizing enzymes in the decidualized uterus of pseudopregnant rats. Reprod Biol Endocrinol. 2015;13(1):5.

Carver KA, Smith TL, Gallagher PE, Tallant EA. Angiotensin-(1-7) prevents angiotensin II-induced fibrosis in cremaster microvessels. Microcirculation. 2015;22(1):19-27.

Schaich CL, Shaltout HA, Grabenauer M, Thomas BF, Gallagher PE, Howlett AC, Diz DI. Alterations in the medullary endocannabinoid system contribute to age-related impairment of baroreflex sensitivity. J Cardiovasc Pharmacol. 2015;65(5):473-479.

Gallagher PE, Arter AL, Deng G, Tallant AE. Angiotensin-(1-7): a peptide hormone with anti-cancer activity. Curr Med Chem. 2014;21(21):2417-2423.

Bracey DN, Willey JS, Tallant EA, Gallagher PE, Wiggins WF, Callahan MF, Smith TL, Emory CL. The endogenous peptide angiotensin-(1-7) prevents radiation-induced muscle fibrosis: an in vivo murine model [abstract]. In: Proceedings of the 2014 Annual Meeting of the American Academy of Orthopaedic Surgeons; 2014 March 15-18; New Orleans (LA). 2014;():.

Yamaleyeva LM, Brosnihan KB, Anton L, McGee C, Mertz HL, Gallagher PE, Merrill DC. Opposing interactions between angiotensin II and apelin in human placental chorionic villi [abstract]. Reprod Sci. 2014;21(3 Suppl):393A.

Tallant EA, Howlett AC, Gallagher PE. Blockade of angiotensin-(1-7)-mediated vascular remodeling by a CB2 cannabinoid receptor antagonist [abstract]. Hypertension. 2014;64(Suppl 1):A542.

Brosnihan KB, Pulgar VM, Varagic J, Oliva K, Bader M, Delbruck M, Dechend R, Gallagher P, Thomas BF, Grabenauer M, Yamaleyeva LM. Increased uterine interimplantation levels of Ang II, AT1R, and CB1R are associated with reduced uterine permeability at early pregnancy in a transgenic model of preeclampsia [abstract]. Hypertension. 2014;64(Suppl 1):A577.

Krishnan B, Smith TL, Dubey P, Zapadka ME, Torti FM, Willingham MC, Tallant EA, Gallagher PE. Angiotensin-(1-7) attenuates metastatic prostate cancer and reduces osteoclastogenesis. Prostate. 2013;73(1):71-82.

Arnold AC, Gallagher PE, Diz DI. Brain renin-angiotensin system in the nexus of hypertension and aging. Hypertens Res. 2013;36(1):5-13.

Krishnan B, Torti FM, Gallagher PE, Tallant EA. Angiotensin-(1-7) reduces proliferation and angiogenesis of human prostate cancer xenografts with a decrease in angiogenic factors and an increase in sFlt-1. Prostate. 2013;73(1):60-70.

Yamaleyeva LM, Neves LA, Coveleskie K, Diz DI, Gallagher PE, Brosnihan KB. AT1, AT2, and AT1-7 receptor expression in the uteroplacental unit of normotensive and hypertensive rats during early and late pregnancy. Placenta. 2013;34(6):497-502.

Gallagher PE, Arter AL, Krishnan B, Garcia-Espinosa MA, Tallant EA. Angiotensin II/angiotensin-(1-7) In: Kastin AJ, ed. Handbook of biologically acive peptides. 2nd ed. Oxford: Academic Press;2013: 494-501.

Varagic J, Gallagher PE. Tissue specific regulation of CB1/CB2 gene receptors in salt sensitive hypertension of SHR [abstract]. FASEB J. 2013;27():1108.8.

Bracey D, Willey JS, Tallant EA, Gallagher PD [sic] [Gallagher PE], Smith TL, Callahan MF, Emory CL. The endogenous peptide angiotensin-(1-7) prevents radiation-induced muscle fibrosis: an in vivo murine model [abstract]. Int J Radiat Oncol Biol Phys. 2013;87(2 Suppl):S167.

Moore ED, Kooshki M, Metheny-Barlow LJ, Gallagher PE, Robbins ME [deceased]. Angiotensin-(1-7) prevents radiation-induced inflammation in rat primary astrocytes through regulation of MAP kinase signaling. Free Radic Biol Med. 2013;65():1060-1068.

Tallant EA, Howlett A, Grabenauer M, Thomas BF, Gallagher PE. The CB2 cannabinoid receptor mediates the anti-proliferative actions of angiotensin-(1-7) in vascular smooth muscle cells [abstract]. Hypertension. 2013;62(3 Suppl):465.

Brosnihan KB, Yamaleyeva LM, Gallagher PE, Pulgar VM, Neves LA. Local uterine Ang-(1-7) infusion augments expression of cannabinoid receptors and differentially alters endocannabinoid metabolizing enzymes in the decidualized uterus of pseudopregnant rats [abstract]. Hypertension. 2013;62(3 Suppl):543.

Varagic J, Gallagher PE, Grabenauer M, Thomas BF. Renal endocannabinoids in salt-sensitive hypertension of SHR [abstract]. Hypertension. 2013;62(3 Suppl):499.

Bracey DN, Willey JS, Tallant EA, Gallagher PE, Smith TL, Callahan MF, Emory CL. Angiotensin-(1-7) prevents radiation-induced muscle fibosis: an in vivo murine model [abstract]. In: Proceedings of the 2013 Annual Meeting of the Southern Orthopedic Association; 2013 July 30-August 2; Palm Beach (FL). 2013;():.

Brosnihan KB, Yamaleyeva L, Gallagher PE, Pulgar V, Neves LAA. Local uterine Ang-(1-7) infusion augments the expression of CB1R, CB2 receptor and MAGL but not FAAH in the decidualized uterus of pseudopregnant rats [abstract]. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

Tallant EA, Howlett A, Grabenauer M, Thomas BF, Gallagher PE. The CB2cannabinoid receptor mediates the anti-proliferative actions of angiotensin-(1-7) in vascular smooth muscle cells [abstract]. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

Varagic J, Gallagher PE, Grabenauer M, Thomas BF. Cardiac and renal endocannabinoids in salt-loaded SHR [abstract]. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

Arter AL, Gallagher PE, Tallant EA. Angiotensin-(1-7) attenuates the proliferation of cancer-associated fibroblasts in triple negative breast cancer [abstract]. Cancer Res. 2013;73(3 Suppl):B34.

Arter A, Gallagher PE, Tallant AE [sic] [Tallant EA]. Angiotensin-(1-7) suppresses lung metastasis in the 4T1 orthotopic mammary carcinoma model [abstract]. In: Proceedings of the 2013 International Conference on Tumor Microenvironment and Cellular Stress; 2013 Sept 27-Oct 2; Corfu (Greece). 2013;():.

McCollum LT, Gallagher PE, Tallant EA. Angiotensin-(1-7) attenuates angiotensin II-induced cardiac remodeling associated with upregulation of dual-specificity phosphatase 1. Am J Physiol Heart Circ Physiol. 2012;302(3):H801-H810.

McCollum LT, Gallagher PE, Tallant EA. Angiotensin-(1-7) abrogates mitogen-stimulated proliferation of cardiac fibroblasts. Peptides. 2012;34(2):380-388.

Yamaleyeva LM, Lindsey SH, Varagic J, Zhang LL, Gallagher PE, Chen AF, Chappell MC. Amelioration of renal injury and oxidative stress by the nNOS inhibitor L-VNIO in the salt-sensitive mRen2.Lewis congenic rat. J Cardiovasc Pharmacol. 2012;59(6):529-538.

Garcia-Espinosa MA, Lesser GJ, Debinski W, Tallant EA, Gallagher PE. Angiotensin-(1-7), a peptide hormone with therapeutic potential for the treatment of glioblastomas [abstract]. In: Proceedings of the 103rd Annual Meeting of the Amerian Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, Illinois. Philadelphia (PA): AACR. 2012;():Abstr 1938.

Arter AA, Metheny-Barlow L, Gallagher PE, Tallant EA. Angiotensin-(1-7) inhibits proliferative and fibrotic signaling mechanisms in triple negative breast cancer [abstract]. In: Proceedings of the 103rd Annual Meeting of the Amerian Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, Illinois. Philadelphia (PA): AACR. 2012;():Abstr 5224.

Garcia-Espinosa MA, Shaltout HA, Gallagher PE, Chappell MC, Diz DI. In vivo expression of angiotensin-(1-7) lowers blood pressure and improves baroreflex function in transgenic (mRen2)27 rats. J Cardiovasc Pharmacol. 2012;60(2):150-157.

Varagic J, Ahmad S, Voncannon JL, Moniwa N, Simington SW Jr, Brosnihan BK, Gallagher PE, Habibi J, Sowers JR, Ferrario CM. Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded spontaneously hypertensive rats. J Hypertens. 2012;30(9):1766-1774.

Nautiyal M, Katakam PV, Busija DW, Gallagher PE, Tallant EA, Chappell MC, Diz DI. Differences in oxidative stress status and expression of MKP-1 in dorsal medulla of transgenic rats with altered brain renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol. 2012;303(8):R799-806.

Carver KA, Smith TL, Gallagher PE, Tallant EA. Vascular remodeling by angiotensin peptide hormones alters reactivity of the microcirculation [abstract]. Hypertension. 2012;60(3 Suppl):530.

Tallant EA, Carver KA, Gallagher PE. Angiotensin-(1-7) attenuates PDGF-dependent migration of vascular smooth muscle cells [abstract]. Hypertension. 2012;60(3 Suppl):512.

Gallagher PE, Maglic D, Krishnan B, Castellino SM, Tallant EA. Angiotensin-(1-7) inhibits the growth of human pediatric rhabdomyosarcoma in a mouse xenograft model [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando (FL). Philadelphia (PA): AACR. 2011;():Abstr 5349.

Gallagher PE, Cook K, Soto-Pantoja D, Menon J, Tallant EA. Angiotensin peptides and lung cancer. Curr Cancer Drug Targets. 2011;11(4):394-404.

Gilliam-Davis S, Gallagher PE, Payne VS, Kasper SO, Tommasi EN, Westwood BM, Robbins ME, Chappell MC, Diz DI. Long-term systemic angiotensin II type 1 receptor blockade regulates mRNA expression of dorsomedial medulla renin-angiotensin system components. Physiol Genomics. 2011;43(13):829-835.

Lindsey SH, Yamaleyeva LM, Brosnihan KB, Gallagher PE, Chappell MC. Estrogen receptor GPR30 reduces oxidative stress and proteinuria in the salt-sensitive female mRen2.Lewis rat. Hypertension. 2011;58(4):665-671.

Carver KA, Smith TL, Gallagher PE, Tallant EA. Angiotensin-(1-7) attenuates angiotensin II-induced fibrosis through a reduction in connective tissue growth factor [abstract]. Hypertension. 2011;58(5):e178.

Lindsey SH, Yamaleyeva LM, Gallagher P, Chappell MC. GPR30 restores megalin expression in the renal cortex of salt-sensitive mRen2.Lewis females [abstract]. Hypertension. 2011;58(5):e182-e183.

Tallant EA, Carver KA, Gallagher PE. Angiotensin-(1-7) reduces cardiac hypertrophy and fibrosis in mRen2.Lewis congenic rats [abstract]. Hypertension. 2011;58(5):e110.

Varagic J, Ahmad S, Gallagher PE, Habibi J, Sowers J, Ferrario CM. Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded SHR [abstract]. Hypertension. 2011;58(5):e80.

Tallant EA, Holmes CH, Gallagher PE. Inhibition of cancer cell growth by muscadine grape seed and grape skin extracts [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, Florida. Philadelphia (PA): AACR. 2011;():Abstr 4220.

Gallagher PE, Tallant EA, Ferrario CM, inventors; Wake Forest University Health Sciences, assignee. Angiotensin-(1-7) and angiotensin-(1-7) agonists for inhibition of cancer cell growth. United States patent US 8,034,781. 2011 Oct 11. 2011;():.

Varagic J, Ahmad S, Brosnihan KB, Groban L, Chappell MC, Tallant EA, Gallagher PE, Ferrario CM. Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction. Ther Adv Cardiovasc Dis. 2010;4(1):17-25.

Trask AJ, Groban L, Westwood BM, Varagic J, Ganten D, Gallagher PE, Chappell MC, Ferrario CM. Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats. Am J Hypertens. 2010;23(6):687-693.

Cohen JA, Lindsey SH, Pirro NT, Brosnihan KB, Gallagher PE, Chappell MC. Influence of estrogen depletion and salt loading on renal angiotensinogen expression in the mRen(2).Lewis strain. Am J Physiol Renal Physiol. 2010;299(1):F35-F42.

Cook KL, Metheny-Barlow LJ, Tallant EA, Gallagher PE. Angiotensin-(1-7) reduces fibrosis in orthotopic breast tumors. Cancer Res. 2010;70(21):8319-8328.

Carver KA, Smith TL, Gallagher PE, Tallant EA. Angiotensin-(1-7) reduces angiotensin II-induced remodeling of the microcirculation [abstract]. Hypertension. 2010;56(5):e141-e142.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Hypertension

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