Profile

Patricia E. Gallagher, Ph.D.Wake Forest School of Medicine

Patricia E. Gallagher, Ph.D.

Professor,




Contact Information

Academic: 336-716-4455 | Department: 336-716-4455

Email: pgallagh@wakehealth.edu

Education & Training

  • B.S., University of Memphis , 1972
  • Ph.D., University of Tennessee-Memphis , 1983
  • Fellowship, Temple University School of Me, 1986

Memberships

  • Am Soc Biochem Molecular Bio
  • Am Soc Of Cancer Research
  • Fed Of Am Soc For Experimental
Patricia E. Gallagher, Ph.D.

Patricia E. Gallagher, Ph.D.

Professor, Surgical Sciences-Hypertension
Comprehensive Cancer Center
Hypertension and Vascular Research Center
Cancer Biology
Physiology & Pharmacology

Research Interests

cancer/oncogenesis, cardiac function, cell growth, differentiation,d, drugs/therapeutic agents pharm, hormones/cytokines/signalling

Contact Information

Academic: 336-716-4455 | Department: 336-716-4455

Email: pgallagh@wakehealth.edu

Recent Publications

Gallagher PE, Arter AL, Deng G, Tallant AE. Angiotensin-(1-7): a peptide hormone with anti-cancer activity. Curr Med Chem. 2014;21(21):2417-2423.

Bracey DN, Willey JS, Tallant EA, Gallagher PE, Wiggins WF, Callahan MF, Smith TL, Emory CL. The endogenous peptide angiotensin-(1-7) prevents radiation-induced muscle fibrosis: an in vivo murine model [abstract]. In: Proceedings of the 2014 Annual Meeting of the American Academy of Orthopaedic Surgeons; 2014 March 15-18; New Orleans (LA). 2014;():.

Yamaleyeva LM, Brosnihan KB, Anton L, McGee C, Mertz HL, Gallagher PE, Merrill DC. Opposing interactions between angiotensin II and apelin in human placental chorionic villi [abstract]. Reprod Sci. 2014;21(3 Suppl):393A.

Krishnan B, Smith TL, Dubey P, Zapadka ME, Torti FM, Willingham MC, Tallant EA, Gallagher PE. Angiotensin-(1-7) attenuates metastatic prostate cancer and reduces osteoclastogenesis. Prostate. 2013;73(1):71-82.

Arnold AC, Gallagher PE, Diz DI. Brain renin-angiotensin system in the nexus of hypertension and aging. Hypertens Res. 2013;36(1):5-13.


Yamaleyeva LM, Neves LA, Coveleskie K, Diz DI, Gallagher PE, Brosnihan KB. AT1, AT2, and AT1-7 receptor expression in the uteroplacental unit of normotensive and hypertensive rats during early and late pregnancy. Placenta. 2013;34(6):497-502.

Gallagher PE, Arter AL, Krishnan B, Garcia-Espinosa MA, Tallant EA. Angiotensin II/angiotensin-(1-7) In: Kastin AJ, ed. Handbook of biologically acive peptides. 2nd ed. Oxford: Academic Press;2013: 494-501.

Varagic J, Gallagher PE. Tissue specific regulation of CB1/CB2 gene receptors in salt sensitive hypertension of SHR [abstract]. FASEB J. 2013;27():1108.8.

Bracey D, Willey JS, Tallant EA, Gallagher PD [sic] [Gallagher PE], Smith TL, Callahan MF, Emory CL. The endogenous peptide angiotensin-(1-7) prevents radiation-induced muscle fibrosis: an in vivo murine model [abstract]. Int J Radiat Oncol Biol Phys. 2013;87(2 Suppl):S167.

Moore ED, Kooshki M, Metheny-Barlow LJ, Gallagher PE, Robbins ME [deceased]. Angiotensin-(1-7) prevents radiation-induced inflammation in rat primary astrocytes through regulation of MAP kinase signaling. Free Radic Biol Med. 2013;65():1060-1068.

Tallant EA, Howlett A, Grabenauer M, Thomas BF, Gallagher PE. The CB2 cannabinoid receptor mediates the anti-proliferative actions of angiotensin-(1-7) in vascular smooth muscle cells [abstract]. Hypertension. 2013;62(3 Suppl):465.

Brosnihan KB, Yamaleyeva LM, Gallagher PE, Pulgar VM, Neves LA. Local uterine Ang-(1-7) infusion augments expression of cannabinoid receptors and differentially alters endocannabinoid metabolizing enzymes in the decidualized uterus of pseudopregnant rats [abstract]. Hypertension. 2013;62(3 Suppl):543.

Varagic J, Gallagher PE, Grabenauer M, Thomas BF. Renal endocannabinoids in salt-sensitive hypertension of SHR [abstract]. Hypertension. 2013;62(3 Suppl):499.

Bracey DN, Willey JS, Tallant EA, Gallagher PE, Smith TL, Callahan MF, Emory CL. Angiotensin-(1-7) prevents radiation-induced muscle fibosis: an in vivo murine model [abstract]. In: Proceedings of the 2013 Annual Meeting of the Southern Orthopedic Association; 2013 July 30-August 2; Palm Beach (FL). 2013;():.

Brosnihan KB, Yamaleyeva L, Gallagher PE, Pulgar V, Neves LAA. Local uterine Ang-(1-7) infusion augments the expression of CB1R, CB2 receptor and MAGL but not FAAH in the decidualized uterus of pseudopregnant rats [abstract]. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

Tallant EA, Howlett A, Grabenauer M, Thomas BF, Gallagher PE. The CB2cannabinoid receptor mediates the anti-proliferative actions of angiotensin-(1-7) in vascular smooth muscle cells [abstract]. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

Varagic J, Gallagher PE, Grabenauer M, Thomas BF. Cardiac and renal endocannabinoids in salt-loaded SHR [abstract]. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

McCollum LT, Gallagher PE, Tallant EA. Angiotensin-(1-7) attenuates angiotensin II-induced cardiac remodeling associated with upregulation of dual-specificity phosphatase 1. Am J Physiol Heart Circ Physiol. 2012;302(3):H801-H810.

McCollum LT, Gallagher PE, Tallant EA. Angiotensin-(1-7) abrogates mitogen-stimulated proliferation of cardiac fibroblasts. Peptides. 2012;34(2):380-388.

Yamaleyeva LM, Lindsey SH, Varagic J, Zhang LL, Gallagher PE, Chen AF, Chappell MC. Amelioration of renal injury and oxidative stress by the nNOS inhibitor L-VNIO in the salt-sensitive mRen2.Lewis congenic rat. J Cardiovasc Pharmacol. 2012;59(6):529-538.

Garcia-Espinosa MA, Lesser GJ, Debinski W, Tallant EA, Gallagher PE. Angiotensin-(1-7), a peptide hormone with therapeutic potential for the treatment of glioblastomas [abstract]. In: Proceedings of the 103rd Annual Meeting of the Amerian Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, Illinois. Philadelphia (PA): AACR. 2012;():Abstr 1938.

Arter AA, Metheny-Barlow L, Gallagher PE, Tallant EA. Angiotensin-(1-7) inhibits proliferative and fibrotic signaling mechanisms in triple negative breast cancer [abstract]. In: Proceedings of the 103rd Annual Meeting of the Amerian Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, Illinois. Philadelphia (PA): AACR. 2012;():Abstr 5224.

Garcia-Espinosa MA, Shaltout HA, Gallagher PE, Chappell MC, Diz DI. In vivo expression of angiotensin-(1-7) lowers blood pressure and improves baroreflex function in transgenic (mRen2)27 rats. J Cardiovasc Pharmacol. 2012;60(2):150-157.

Varagic J, Ahmad S, Voncannon JL, Moniwa N, Simington SW Jr, Brosnihan BK, Gallagher PE, Habibi J, Sowers JR, Ferrario CM. Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded spontaneously hypertensive rats. J Hypertens. 2012;30(9):1766-1774.

Nautiyal M, Katakam PV, Busija DW, Gallagher PE, Tallant EA, Chappell MC, Diz DI. Differences in oxidative stress status and expression of MKP-1 in dorsal medulla of transgenic rats with altered brain renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol. 2012;303(8):R799-806.

Carver KA, Smith TL, Gallagher PE, Tallant EA. Vascular remodeling by angiotensin peptide hormones alters reactivity of the microcirculation [abstract]. Hypertension. 2012;60(3 Suppl):530.

Tallant EA, Carver KA, Gallagher PE. Angiotensin-(1-7) attenuates PDGF-dependent migration of vascular smooth muscle cells [abstract]. Hypertension. 2012;60(3 Suppl):512.

Gallagher PE, Maglic D, Krishnan B, Castellino SM, Tallant EA. Angiotensin-(1-7) inhibits the growth of human pediatric rhabdomyosarcoma in a mouse xenograft model [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando (FL). Philadelphia (PA): AACR. 2011;():Abstr 5349.

Gallagher PE, Cook K, Soto-Pantoja D, Menon J, Tallant EA. Angiotensin peptides and lung cancer. Curr Cancer Drug Targets. 2011;11(4):394-404.

Gilliam-Davis S, Gallagher PE, Payne VS, Kasper SO, Tommasi EN, Westwood BM, Robbins ME, Chappell MC, Diz DI. Long-term systemic angiotensin II type 1 receptor blockade regulates mRNA expression of dorsomedial medulla renin-angiotensin system components. Physiol Genomics. 2011;43(13):829-835.

Lindsey SH, Yamaleyeva LM, Brosnihan KB, Gallagher PE, Chappell MC. Estrogen receptor GPR30 reduces oxidative stress and proteinuria in the salt-sensitive female mRen2.Lewis rat. Hypertension. 2011;58(4):665-671.

Carver KA, Smith TL, Gallagher PE, Tallant EA. Angiotensin-(1-7) attenuates angiotensin II-induced fibrosis through a reduction in connective tissue growth factor [abstract]. Hypertension. 2011;58(5):e178.

Lindsey SH, Yamaleyeva LM, Gallagher P, Chappell MC. GPR30 restores megalin expression in the renal cortex of salt-sensitive mRen2.Lewis females [abstract]. Hypertension. 2011;58(5):e182-e183.

Tallant EA, Carver KA, Gallagher PE. Angiotensin-(1-7) reduces cardiac hypertrophy and fibrosis in mRen2.Lewis congenic rats [abstract]. Hypertension. 2011;58(5):e110.

Varagic J, Ahmad S, Gallagher PE, Habibi J, Sowers J, Ferrario CM. Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded SHR [abstract]. Hypertension. 2011;58(5):e80.

Tallant EA, Holmes CH, Gallagher PE. Inhibition of cancer cell growth by muscadine grape seed and grape skin extracts [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, Florida. Philadelphia (PA): AACR. 2011;():Abstr 4220.

Gallagher PE, Tallant EA, Ferrario CM, inventors; Wake Forest University Health Sciences, assignee. Angiotensin-(1-7) and angiotensin-(1-7) agonists for inhibition of cancer cell growth. United States patent US 8,034,781. 2011 Oct 11. 2011;():.

Varagic J, Ahmad S, Brosnihan KB, Groban L, Chappell MC, Tallant EA, Gallagher PE, Ferrario CM. Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction. Ther Adv Cardiovasc Dis. 2010;4(1):17-25.

Trask AJ, Groban L, Westwood BM, Varagic J, Ganten D, Gallagher PE, Chappell MC, Ferrario CM. Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats. Am J Hypertens. 2010;23(6):687-693.

Cohen JA, Lindsey SH, Pirro NT, Brosnihan KB, Gallagher PE, Chappell MC. Influence of estrogen depletion and salt loading on renal angiotensinogen expression in the mRen(2).Lewis strain. Am J Physiol Renal Physiol. 2010;299(1):F35-F42.

Cook KL, Metheny-Barlow LJ, Tallant EA, Gallagher PE. Angiotensin-(1-7) reduces fibrosis in orthotopic breast tumors. Cancer Res. 2010;70(21):8319-8328.

Carver KA, Smith TL, Gallagher PE, Tallant EA. Angiotensin-(1-7) reduces angiotensin II-induced remodeling of the microcirculation [abstract]. Hypertension. 2010;56(5):e141-e142.

Nautiyal M, Katakam PV, Busija DW, Gallagher PE, Tallant EA, Chappell MC, Diz DI. Oxidative stress and low expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in dorsal medulla of hypertensive (mRen2)27 transgenic rats [abstract]. Hypertension. 2010;56(5):e156.

Cook KL, Soto PD, Gallagher P, Tallant EA. Angiotensin-(1-7) inhibition of human breast tumors with distinct hormone receptor expression results in a differential regulation of AKT [abstract]. Cancer Res. 2009;69(2 Suppl):240S.

Soto-Pantoja DR, Petty WJ, Gallagher PE, Tallant EA. Angiotensin-(1-7) inhibits triple negative tumor growth through the inhibition of angiogenesis and a reduction in placental growth factor PIGF [abstract]. Cancer Res. 2009;69(2 Suppl):103S.

Soto-Pantoja DR, Menon J, Gallagher PE, Tallant EA. Angiotensin-(1-7) inhibits tumor angiogenesis in human lung cancer xenografts with a reduction in vascular endothelial growth factor. Mol Cancer Ther. 2009;8(6):1676-1683.

Lindsey SH, Cohen JA, Brosnihan KB, Gallagher PE, Chappell MC. Chronic treatment with the G protein-coupled receptor 30 agonist G-1 decreases blood pressure in ovariectomized mRen2.Lewis rats. Endocrinology. 2009;150(8):3753-3758.

Anton L, Merrill DC, Neves LAA, Diz DI, Corthorn J, Stovall K, Gallagher PE, Moorefield C, Gruver C, Brosnihan KB, et al. The uterine placental bed renin-angiotensin system in normal and preeclamptic pregnancy. Endocrinology. 2009;150(9):4316-4325.

Arnold AC, Shaltout HA, Gallagher PE, Diz DI. Leptin impairs cardiovagal baroreflex function at the level of the solitary tract nucleus. Hypertension. 2009;54(5):1001-1008.

Arnold AC, Shaltout HA, Gallagher PE, Diz DI. Protein phosphatase 1b activity in the solitary tract nucleus is necessary for normal baroreflex function [abstract]. Hypertension. 2009;54(4):e100.

Petty WJ, Miller AA, McCoy TP, Gallagher PE, Tallant EA, Torti FM. Phase I and pharmacokinetic study of angiotensin-(1-7), an endogenous antiangiogenic hormone. Clin Cancer Res. 2009;15(23):7398-7404.

Gallagher PE, Tallant EA. Angiotensin-(1-7) reduces MAP kinase activity by upregulation of the dual-specificity phosphatase DUSP1 [abstract]. Hypertension. 2009;54(4):e35.

Tallant EA, McCollum LT, Gallagher PE. Angiotensin-(1-7) reduces Ang II-induced cardiac hypertrophy with an associated increase in the dual-specificity phosphatase 1 (DUSP1) [abstract]. Hypertension. 2009;54(4):e122.

Petty WJ, Miller AA, McCoy TP, Gallagher PE, Tallant EA, Torti FM. Phase I study of angiotensin-(1-7), an endogenous antiangiogenic hormone: clinical, pharmacokinetic, and biomarker findings [abstract]. Mol Cancer Ther. 2009;8(12 Suppl 1):B208.

Lesser GJ, Carver KA, Newton SJ, Tallant EA, Gallagher PE. Angiotensin-(1-7), a small molecule inhibitor of glioblastoma growth [abstract]. J Clin Oncol. 2009;27(15 Suppl):2024.

Neves LAA, Stovall K, Joyner J, Valdes G, Gallagher PE, Ferrario CM, Merrill DC, Brosnihan KB. ACE2 and ANG-(1-7) in the rat uterus during early and late gestation. Am J Physiol Regul Integr Comp Physiol. 2008;294(1):R151-R161.

Anton L, Merrill DC, Neves LAA, Stovall K, Gallagher PE, Diz DI, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. Activation of local chorionic villi angiotensin II levels but not angiotensin (1-7) in preelampsia. Hypertension. 2008;51(4):1066-1072.

Jessup JA, Brosnihan KB, Gallagher PE, Chappell MC, Ferrario CM. Differential effect of low-dose thiazides on the renin angiotensin system in genetically hypertensive and normotensive rats. J Am Soc Hypertens. 2008;2(2):106-115.


Diz DI, Garcia-Espinosa MA, Gegick S, Tommasi EN, Ferrario CM, Tallant EA, Chappell MC, Gallagher PE. Injections of angiotensin-converting enzyme 2 inhibitor MLN4760 into nucleus tractus solitarii reduce baroreceptor reflex sensitivity for heart rate control in rats. Exp Physiol. 2008;93(5):694-700.

Menon J, Miller MS, Soto-Pantoja DR, Callahan MF, Tallant EA, Gallagher PE. Angiotensin-(1-7) reduces lung tumor incidence in a novel bitransgenic Ki-ras G12C mouse model of lung tumorigenesis through a reduction in cyclooxygenase-2 [abstract]. In: Proceedings of the 99th Annual Meeting of the American Association for Cancer Research; 2008 Apr 12-16; San Diego, CA. Philadelphia (PA): AACR. 2008;():Abstr 4654.

Soto-Pantoja DR, Menon J, Gallagher PE, Tallant EA. Angiotensin-(1-7) inhibits the growth of human triple negative breast tumors in an orthotopic model [abstract]. In: Proceedings of the 99th Annual Meeting of the American Association for Cancer Research ; 2008 Apr 12-16; San Diego (CA). Philadelphia (PA): AACR. 2008;():Abstr 2416.

Petty WJ, Miller AA, McCoy TP, Gallagher PE, Tallant EA, Torti FM. Bi-directional translational research with angiotensin-(1-7) uncovers placental growth factor as a therapeutic target [abstract]. In: Proceedings of the 99th Annual Meeting of the American Association for Cancer Research ; 2008 Apr 12-16; San Diego (CA). Philadelphia (PA): AACR. 2008;():Abstr 4968.

Diz DI, Garcia-Espinosa MA, Gallagher PE, Ganten D, Ferrario CM, Averill DB. Angiotensin-(1-7) and baroreflex function in nucleus tractus solitarii of (mRen2)27 transgenic rats. J Cardiovasc Pharmacol. 2008;51(6):542-548.

Tallant EA, Gallagher PE, Ferrario CM, inventors; Wake Forest University Health Sciences, assignee. Angiotensin (1-7) and angiotensin (1-7) agonists for inhibition of cancer cell growth. United States patent US 7,375,073. 2008 May 20. 2008;():.

Gallagher PE, Ferrario CM, Tallant EA. MAP kinase/phosphatase pathway mediates the regulation of ACE2 by angiotensin peptides. Am J Physiol Cell Physiol. 2008;295(5):C1169-1174.

Lesser G, Carver K, Newton S, Tallant EA, Gallagher P. Angiotensin-(1-7) inhibits the growth of human glioblastoma xenografts in nude mice [abstract]. Neuro Oncol. 2008;10(5):792.

Anton L, Merrill DC, Diz D, Neves LA, Gallagher PE, Stovall K, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. Elevation of maternal uterine placental bed angiotensin II levels is associated with increased renin and ACE mRNA in preeclampsia [abstract]. Hypertension. 2008;52(4):e49.

Arnold AC, Shaltout HA, Gallagher PE, Ganten D, Ferrario CM, Diz DI. Leptin impairs baroreflex sensitivity at the solitary tract nucleus: evidence for upregulation of leptin actions in animals with low brain angiotensinogen [abstract]. Hypertension. 2008;52(4):e50.

Gallagher PE, Ferrario CM, Tallant EA. Regulation of ACE2 in cardiac myocytes and fibroblasts. Am J Physiol Heart Circ Physiol. 2008;295(6):H2373-79.

Gallagher PE, Soto-Pantoja DR, Tallant EA. Angiotensin-(1-7) reduces endothelial cell growth and migration and increases VEGI to inhibit angiogenesis [abstract]. Hypertension. 2008;52(4):e72.

Garcia-Espinosa MA, Shaltout HA, Chappell MC, Gallagher PE, Ferrario CM, Ganten D, Reudelhuber TL, Diz DI. Angiotensin-(1-7) replacement gene transfer in the cisterna magna lowers blood pressure and improves baroreflex function in transgenic (mRen2)27 rats [abstract]. Hypertension. 2008;52(4):e36.

Gilliam-Davis S, Gallagher PE, Payne VS, Kasper SO, Tommasi EN, Robbins ME, Diz DI. Long-term systemic renin-angiotensin system blockade alters expression of renin-angiotensin system components in dorsomedial medulla of Fischer 344 rats [abstract]. Hypertension. 2008;52(4):e61.

McCollum LT, Gallagher PE, Tallant EA. Angiotensin-(1-7) attenuates cardiac fibrosis and vascular hypertrophy in a model of angiotensin II-dependent hypertension [abstract]. Hypertension. 2008;52(4):e120.

Tallant EA, McCollum LT, Gallagher PE. Angiotensin-(1-7) increases DUSP-1 and reduces the endothelin-1-mediated increase in COX-2 and PGES-1 in cardiac fibroblasts [abstract]. Hypertension. 2008;52(4):e47-e48.

Yamaleyeva LM, Lindsey SH, Gallagher PE, Chappell MC. Distribution and regulation of the novel estrogen receptor GPR30 in the female mRen2.Lewis rat kidney [abstract]. Hypertension. 2008;52(4):e93.

Anton L, Merrill D, Diz D, Neves L, Gallagher P, Stovall K, Moorefield C, Gruver C, Ferrario C, Brosnihan KB. Does the activated RAS with suppression of all Ang receptors in the preeclamptic maternal uterus play an endocrine role on the placenta? [abstract]. Hypertens Pregnancy. 2008;27(4):508.

Jessup JA, Brosnihan KB, Gallagher PE, Chappell MC, Ferrario CM. Differential effect of low dose thiazides on the renin angiotensin system in genetically hypertensive and normotensive rats. J Am Soc Hypertens. 2008;2(2):106-115.

Petty WJ, Miller AA, McCoy TP, Gallagher PE, Tallant EA, Torti FM. Phase I trial of angiotensin-(1-7): an endogenous anti-angiogenic hormone [abstract]. J Clin Oncol. 2008;26(15 Suppl):634s.

Yamaleyeva LM, Gallagher PE, Vinsant S, Chappell MC. Discoordinate regulation of renal nitric oxide synthase isoforms in ovariectomized mRen2.Lewis rats. Am J Physiol Regul Integr Comp Physiol. 2007;292(2):R819-R826.

Sakima A, Averill DB, Kasper SO, Jackson L, Ganten D, Ferrario CM, Gallagher PE, Diz DI. Baroreceptor reflex regulation in anesthetized transgenic rats with low glia-derived angiotensinogen. Am J Physiol Heart Circ Physiol. 2007;292(3):H1412-1419.

Menon J, Soto-Pantoja DR, Callahan MF, Cline JM, Ferrario CM, Tallant EA, Gallagher PE. Angiotensin-(1-7) inhibits growth of human lung adenocarcinoma xenografts in nude mice through a reduction in cyclooxygenase-2. Cancer Res. 2007;67(6):2809-2815.

Yamaleyeva LM, Gallagher PE, Groban L, Chappell MC. Increased intra-renal IGF-1 is associated with renal injury in older estrogen-depleted mRen2.Lewis rats [abstract]. FASEB J. 2007;21(6 Pt II):A1421.

Yamaleyeva LM, Pendergrass KD, Pirro NT, Gallagher PE, Groban L, Chappell MC. Ovariectomy is protective against renal injury in the high-salt fed older mRen2.Lewis rat. Am J Physiol Heart Circ Physiol. 2007;293(4):H2064-2071.

Anton L, Merrill DC, Diz DI, Neves LA, Stovall K, Gallagher PE, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. The increased shift of the Ang II/Ang-(1-7) balance in the chorionic villi from preeclamptic subjects is mediated by the AT1 receptor [abstract]. Hypertension. 2007;50(4):e79.

Brosnihan KB, Stovell K, Gallagher PE, Ferrario CM, Neves LA. Intrauterine Ang-(1-7) infusion attenuates PGE2 and PGF1 alpha but not TXB2 in decidualized uterus of pseudopregnant rats [abstract]. Hypertension. 2007;50(4):e102.

Gallagher PE, Soto-Pantoja DR, Tallant EA. Angiotensin-(1-7) inhibits angiogenesis by reducing endothelial cell growth [abstract]. Hypertension. 2007;50(4):e91.

Tallant EA, Gallagher PE. Angiotensin-(1-7) upregulates the mitogen-activated phosphatase DUSP1 in vascular smooth muscle cells [abstract]. Hypertension. 2007;50(4):e77.

Varagic J, Brosnihan KB, Groban L, Gallagher PE, Ferrario CM. Decreased expression of cardiac ACE2 is associated with salt-induced cardiac remodeling and dysfunction [abstract]. Hypertension. 2007;50(4):e150.

Ferrario CM, Averill DB, Brosnihan KB, Chappell MC, Diz DI, Gallagher PE, Neves L, Tallant EA. Regulation of cardiovascular control mechanisms by angiotensin (1-7) and angiotensin-converting enzyme 2 In: Carey RM, ed. Hypertension and hormone mechanisms. Totowa (NJ): Humana Press;2007: 43-59.

Neves LAA, Chappell MC, Ferrario CM, Gallagher PE, Ganten D, Brosnihan KB. Effect of estrogen on neprilysin expression in uterus and kidney of Sprague-Dawley normotensive and heterozygous (mRen2)27-transgenic hypertensive rats. Peptides. 2006;27(11):2912-2918.

Joyner J, Neves LAA, Gallagher PE, Chappell MC, Ferrario CM, Brosnihan KB. Kidney ACE2 mRNA and activity in virgin and normal pregnant Sprague Dawley rats [abstract]. J N C Acad Sci. 2006;122(2):80.

Neves LA, Stovall K, Gallagher PE, Valdes G, Ferrario CM, Merrill DC, Brosnihan KB. Ang-(1-7) concentration and ACE2 mRNA levels are downregulated during the process of implantation and decidualization in Sprague-Dawley rats [abstract]. Hypertens Pregnancy. 2006;25(Suppl 1):20.

Jessup JA, Gallagher PE, Averill DB, Brosnihan KB, Tallant EA, Chappell MC, Ferrario CM. Effect of angiotensin II blockade on a new congenic model of hypertension derived from transgenic Ren-2 rats. Am J Physiol Heart Circ Physiol. 2006;291(5):H2166-2172.

Whaley-Connell AT, Chowdhury NA, Hayden MR, Stump CS, Habibi J, Wiedmeyer CE, Gallagher PE, Tallant EA, Cooper SA, Ferrario C, et al. Oxidative stress and glomerular filtration barrier injury: role of the renin-angiotensin system in the Ren2 transgenic rat. Am J Physiol Renal Physiol. 2006;291(6):F1308-1314.

Conner KR, Forbes ME, Gallagher PE, Robbins ME, Riddle DR. Assessing the effects of AT1 receptor blockade on WBI-induced brain damage [abstract]. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.

Anton L, Merrill DC, Neves LA, Gallagher PE, Moorefield C, Gruver C, Ferrario CM, Brosnihan KB. Increased expression of AT1 receptor and angiotensinogen mRNA and Ang II in human placental chorionic villi of preeclamptic pregnant subjects [abstract]. Hypertension. 2006;48(4):e95.

Brosnihan KB, Neves LA, Gallagher P, Hodgin JB, Smithies O, Maeda N. Differential regulation by ER alpha and ER beta for ACE and ACE2 [abstract]. Hypertension. 2006;48(4):e49.

Diz DI, Tommasi EN, Ferrario CM, Tallant EA, Gallagher PE. ACE2 inhibition in the nucleus of the solitary tract reduces baroreceptor reflex sensitivity [abstract]. Hypertension. 2006;48(4):e87.

Gallagher PE, Ferrario CM, Tallant EA. Molecular mechanisms for the regulation of angiotensin converting enzyme 2 by angiotensin peptides in vascular smooth muscle cells [abstract]. Hypertension. 2006;48(4):e72.

Garcia-Espinosa MA, Gallagher PE, Ganten D, Ferrario CM, Reudlehuber TL, Diz DI. Intracisternal injection of angiotensin-(1-7)-producing fusion protein plasmid lowers blood pressure in hypertensive (mRen2)27 rats [abstract]. Hypertension. 2006;48(4):e87.

Jessup JA, Gallagher PE, Chappell MC, Ferrario CM. Impaired counter-regulatory response of angiotensin converting enzyme 2 (ACE2) and angiotensin-(1-7) [Ang-(1-7)] in the heart of a new congenic model of hypertension derived from [mRen2]27 transgenic rats [abstract]. Hypertension. 2006;48(4):e74.

Joyner J, Neves L, Gallagher P, Merrill D, Ferrario C, Brosnihan KB. Counter-regulation of ACE and ACE2 gene expression in the kidney of normal pregnant rats [abstract]. Hypertension. 2006;48(4):e95.

McCollum LT, Gallagher PE, Ferrario CM, Tallant EA. Angiotensin-(1-7) reduces COX-2 in cardiac fibroblasts [abstract]. Hypertension. 2006;48(4):e79.

Garcia-Espinosa MA, Vinsant S, Gallagher PE, Ferrario CM, Ganten D, Chappell MC, Diz DI. Regulation of brain neprilysin and ACE2 in transgenic rats during aging [abstract]. Am J Med Sci. 2006;331(2):61.

Tallant EA, Ferrario CM, Gallagher PE. Cardioprotective role for angiotensin-(1-7) and angiotensin converting enzyme 2 in the heart. Future Cardiol. 2006;2(3):335-342.

Gallagher PE, Tallant EA, Ferrario CM. Angiotensin converting enzyme 2: a potential target for cardiovascular therapy In: Re RN, DiPette DJ, Schiffrin EL, Sowers JR, eds. Molecular mechanisms in hypertension. New York: Taylor & Francis;2006: 51-59.

Tallant EA, Menon J, Soto-Pantoja DR, Gallagher PE. Angiotensin peptides and cancer In: Kastin AJ, ed. Handbook of biologically active peptides. Boston: Academic Press;2006: 459-465.

Menon J, Tallant EA, Gallagher PE. Experimental and molecular therapeutics 17: novel therapeutic targets [abstract]. In: Proceedings of the 97th Annual Meeting of the American Association for Cancer Research ; 2006 Apr 1-5; Washington, DC. Philadelphia (PA): AACR. 2006;():Abstr 2160.

Soto-Pantoja DR, Gallagher PE, Tallant EA. Inhibition of angiogenesis by angiotensin-(1-7) [abstract]. In: Proceedings of the 97th Annual Meeting of the American Association for Cancer Research ; 2006 Apr 1-5; Washington, DC. Philadelphia (PA): AACR. 2006;():Abstr 950.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Quick Reference

Request an Appointment
New Patients

336-716-WAKE
888-716-WAKE

Existing patients may contact the clinic directly.
Find a Doctor Ways to Give
USNWR 2013-2014Magnet Hospital RecognitionConsumer Choice2014 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.