Profile

Jason M. Grayson, Ph.D.

Jason M. Grayson, Ph.D.

Associate Professor, Microbiology & Immunology
Comprehensive Cancer Center
Contact Information
Office:
336-716-2011
Email: jgrayson@wakehealth.edu
Education & Training
  BS University of Maryland-College Park 1991
  PhD University of Texas Health Sci Center-Dallas 1997
Fellowship Immunology Emory University 2001
Jason M. Grayson, Ph.D.

Jason M. Grayson, Ph.D.

Associate Professor, Microbiology & Immunology
Comprehensive Cancer Center
Contact Information
Office:
336-716-2011
Email: jgrayson@wakehealth.edu
Research Interests
cell growth, differentiation,d , immunology/allergy/inflammatio
Recent Publications
Shin J, O'Brien TF, Grayson JM, Zhong X-P. Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases. J Immunol. 2012; 188(5):2111-2117.

Mitchell LM, Brzoza-Lewis KL, Henry CJ, Grayson JM, Westcott MM, Hiltbold EM. Distinct responses of splenic dendritic cell subsets to infection with Listeria monocytogenes: maturation phenotype, level of infection, and T cell priming capacity ex vivo. Cell Immunol. 2011; 268(2):79-86.

Crump K, Liu C, Konopitski A, Poole L, Haas K, Grayson J. The role of reactive oxygen intermediates in B cell activiation and differentiation [abstract]. J Immunol. 2011; 186(1 Meeting Abstracts):45.12.

Weant AE, Michalek RD, Crump KE, Liu C, Konopitski AP, Grayson JM. Defects in apoptosis increase memory CD8+ T cells following infection of Bim-/-Faslpr/lpr mice. Cell Immunol. 2011; 271(2):256-266.

Henry CJ, Grayson JM, Brzoza-Lewis K, Mitchell LM, Westcott MM, Cook AS, Hiltbold EM. The roles of IL-12 and IL-23 in CD8+ T cell-mediated immunity against Listeria monocytogenes: insights from a DC vaccination model. Cell Immunol. 2010; 264(1):23-31.

Wilhelm AJ, Zabalawi M, Owen JS, Shah D, Grayson JM, Major AS, Bhat S, Gibbs DP Jr, Thomas MJ, Sorci-Thomas MG. Apolipoprotein A-I modulates regulatory T cells in autoimmune LDLr-/-, ApoA-I-/- mice. J Biol Chem. 2010; 285(46):36158-69.

Wilhelm AJ, Zabalawi M, Grayson JM, Major AS, Owen JS, Bhat S, Gibbs DP, Thomas MJ, Sorci-Thomas MG. Apolipoprotein A-I improves the regulatory T-cell response in autoimmune LDLr-/-, ApoA-I-/- mice [abstract]. Arterioscler Thromb Vasc Biol. 2010; 30(11):e269.

Pendergrass KD, Gwathmey TM, Michalek RD, Grayson JM, Chappell MC. The angiotensin II-AT1 receptor stimulates reactive oxygen species within the cell nucleus. Biochem Biophys Res Commun. 2009; 384(2):149-154.

Wilhelm AJ, Zabalawi M, Grayson JM, Weant AE, Major AS, Owen J, Bharadwaj M, Walzem R, Thomas MJ, Sorci-Thomas MG, et al. Apolipoprotein A-I and its role in lymphocyte cholesterol homeostasis and autoimmunity. Arterioscler Thromb Vasc Biol. 2009; 29(6):843-849.

Wilhelm AJ, Zabalawi M, Grayson JM, Weant AE, Major AS, Owen JS, Thomas MJ, Sorci-Thomas MG. Apolipoprotein A-I: a common link between inflammation, atherosclerosis, and autoimmunity [abstract]. Arterioscler Thromb Vasc Biol. 2009; 29(7):e13.

Pendergrass KD, Gwathmey TYM, Grayson JM, Chappell MC. Protein kinase C and PI3 kinase mediate Ang II-dependent generation of reactive oxygen species in renal nuclei [abstract]. FASEB J. 2009; 23(1 Meeting Abstracts):803.7.

Weant AE, Michalek RD, Khan IU, Holbrook BC, Willingham MC, Grayson JM. Apoptosis regulators Bim and Fas function concurrently to control autoimmunity and CD8+ T cell contraction. Immunity. 2008; 28(2):218-230.

Wilhelm AJ, Zabalawi M, Grayson J, Weant AE, Sorci-Thomas M. Absence of ApoA-I leads to dysregulation of lymph node immune cell cholesterol homeostasis and increased atherosclerosis in LDLr-/-, ApoA-I-/- mice [abstract]. Arterioscler Thromb Vasc Biol. 2008; 28(6):e-65.

Michalek RD, Pellom ST, Holbrook BC, Grayson JM. The requirement of reactive oxygen intermediates for lymphocytic choriomeningitis virus binding and growth. Virology. 2008; 379(2):205-212.

Pendergrass KD, Gwathmey TM, Michalek RD, Grayson JM, Chappell MC. Nuclear angiotensin II AT1 receptors mediate the formation of reactive oxygen species [abstract]. Hypertension. 2008; 52(4):e48.

Constantin CM, Masopust D, Gourley T, Grayson J, Strickland OL, Ahmed R, Bonney EA. Normal establishment of virus-specific memory CD8 T cell pool following primary infection during pregnancy. J Immunol. 2007; 179(7):4383-4389.

Michalek RD, Nelson KJ, Holbrook BC, Yi JS, Stridiron D, Daniel LW, Fetrow JS, King SB, Poole LB, Grayson JM. The requirement of reversible cysteine sulfenic acid formation for T cell activation and function. J Immunol. 2007; 179(10):6456-6467.

Gamero AM, Potla R, Wegrzyn J, Szelag M, Edling AE, Shimoda K, Link DC, Dulak J, Baker DP, Grayson JM, et al. Activation of Tyk2 and Stat3 is required for the apoptotic actions of interferon-beta in primary pro-B cells. J Biol Chem. 2006; 281(24):16238-44.

Yi JS, Holbrook BC, Michalek RD, Laniewski NG, Grayson JM. Electron transport complex I is required for CD8+ T cell function. J Immunol. 2006; 177(2):852-862.

Grayson JM, Weant AE, Holbrook BC, Hildeman D. Role of Bim in regulating CD8+ T-cell responses during chronic viral infection. J Virol. 2006; 80(17):8627-8638.
All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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Last Updated 5/10/2012
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