Jason M. Grayson, Ph.D.Wake Forest School of Medicine

Jason M. Grayson, Ph.D.

Associate Professor,

Contact Information

Academic: 336-716-0268 | Department: 336-716-2011


Education & Training

  • B.S., University of Maryland-College Park, 1991
  • Ph.D., University of Texas Health Sci Center-Dallas, 1997
  • Fellowship, Immunology, Emory University, 2001
Jason M. Grayson, Ph.D.

Jason M. Grayson, Ph.D.

Associate Professor, Microbiology & Immunology

Research Interests

cancer/oncogenesis, cell growth, differentiation,d, cross(mult/tnslat/inter)discip, immunology/allergy/inflammatio, infectious diseases, vaccines

Contact Information

Academic: 336-716-0268 | Department: 336-716-2011


Recent Publications

McIver ZA, Grayson J, Hill J, Schamerhorn GA, Ohulchanskyy TY, Linder MK, Davies KS, Weiner R, Detty MR. Targeting T cell bioenergetics by modulating P-glycoprotein improves selectivity of phototherapy [abstract]. Biol Blood Marrow Transplant. 2016;22(3 Suppl 1):S89-S90.

McIver ZA, Kryman MW, Choi Y, Coe BN, Schamerhorn GA, Linder MK, Davies KS, Hill JE, Sawada GA, Grayson JM, Detty MR. Selective photodepletion of malignant T cells in extracorporeal photopheresis with selenorhodamine photosensitizers. Bioorg Med Chem. 2016;():.

Grieves JL, Fye JM, Harvey S, Grayson JM, Hollis T, Perrino FW. Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease. Proc Natl Acad Sci U S A. 2015;112(16):5117-5122.

Langston PK, Yang M, Bierbach U, Parsonage D, Poole LB, Price MJ, Grayson JM. Au-ACRAMTU-PEt3 alters redox balance to inhibit T cell proliferation and function. J Immunol. 2015;195(5):1984-1994.

McIver ZA, Phipps JP, Grayson JM, Hill JE, Schamerhorn GA, Ohulchanskyy TY, Linder MK, Davies KS, Weiner RS, Detty MR. P-glycoprotein modulation facilitates the selective inhibition of oxidative phosphorylation in alloreactive T cells to prevent graft-versus-host disease after hematopoietic stem cell transplant [abstract]. Blood. 2015;126(23):1879.

Lykken JM, DiLillo DJ, Weimer ET, Roser-Page S, Heise MT, Grayson JM, Weitzmann MN, Tedder TF. Acute and chronic B cell depletion disrupts CD4+ and CD8+ T cell homeostasis and expansion during acute viral infection in mice. J Immunol. 2014;193(2):746-756.

Barton ES, Rajkarnikar S, Langston PK, Price MJ, Grayson JM. Gammaherpesvirus latency differentially impacts the generation of primary versus secondary memory CD8+T cells during subsequent infection. J Virol. 2014;88(21):12740-51.

Jennings RN, Grayson JM, Barton ES. Type I interferon signaling enhances CD8+ T cell effector function and differentiation during murine gammaherpesvirus 68 infection. J Virol. 2014;88(24):14040-49.

Gorentla BK, Krishna S, Shin J, Inoue M, Shinohara ML, Grayson JM, Fukunaga R, Zhong XP. Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis. J Immunol. 2013;190(3):1026-1037.

Crump KE, Langston PK, Rajkarnikar S, Grayson JM. Antioxidant treatment regulates the humoral immune response during acute viral infection. J Virol. 2013;87(5):2577-2586.

Grayson J, Jennings R, Rajkarnikar S, Barton E. Herpesvirus latency differentially impacts primary versus secondary memory T cell pools [abstract]. J Immunol. 2013;190():P6119.

Pellom ST, Michalek RD, Crump KE, Langston PK, Juneau DG, Grayson JM. Increased cell surface free thiols identify effector CD8+ T cells undergoing T cell receptor stimulation. PLoS One. 2013;8(11):e81134.

Shin J, O'Brien TF, Grayson JM, Zhong X-P. Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases. J Immunol. 2012;188(5):2111-2117.

Tang S, Moore ML, Grayson JM, Dubey P. Increased CD8+ T-cell function following castration and immunization is countered by parallel expansion of regulatory T cells. Cancer Res. 2012;72(8):1975-1985.

Amoah S, Yammani RD, Grayson JM, Alexander-Miller MA. Changes in functional but not structural avidity during differentiation of CD8+ effector cells in vivo after virus infection. J Immunol. 2012;189(2):638-645.

Crump KE, Juneau DG, Poole LB, Haas KM, Grayson JM. The reversible formation of cysteine sulfenic acid promotes B-cell activation and proliferation. Eur J Immunol. 2012;42(8):2152-2164.

Michalek RD, Crump KE, Weant AE, Hiltbold EM, Juneau DG, Moon EY, Yu DY, Poole LB, Grayson JM. Peroxiredoxin II regulates effector and secondary memory CD8+ T cell responses. J Virol. 2012;86(24):13629-41.

Mitchell LM, Brzoza-Lewis KL, Henry CJ, Grayson JM, Westcott MM, Hiltbold EM. Distinct responses of splenic dendritic cell subsets to infection with Listeria monocytogenes: maturation phenotype, level of infection, and T cell priming capacity ex vivo. Cell Immunol. 2011;268(2):79-86.

Crump K, Liu C, Konopitski A, Poole L, Haas K, Grayson J. The role of reactive oxygen intermediates in B cell activiation and differentiation [abstract]. J Immunol. 2011;186(1 Meeting Abstracts):45.12.

Weant AE, Michalek RD, Crump KE, Liu C, Konopitski AP, Grayson JM. Defects in apoptosis increase memory CD8+ T cells following infection of Bim-/-Faslpr/lpr mice. Cell Immunol. 2011;271(2):256-266.

Henry CJ, Grayson JM, Brzoza-Lewis K, Mitchell LM, Westcott MM, Cook AS, Hiltbold EM. The roles of IL-12 and IL-23 in CD8+ T cell-mediated immunity against Listeria monocytogenes: insights from a DC vaccination model. Cell Immunol. 2010;264(1):23-31.

Wilhelm AJ, Zabalawi M, Owen JS, Shah D, Grayson JM, Major AS, Bhat S, Gibbs DP Jr, Thomas MJ, Sorci-Thomas MG. Apolipoprotein A-I modulates regulatory T cells in autoimmune LDLr-/-, ApoA-I-/- mice. J Biol Chem. 2010;285(46):36158-69.

Wilhelm AJ, Zabalawi M, Grayson JM, Major AS, Owen JS, Bhat S, Gibbs DP, Thomas MJ, Sorci-Thomas MG. Apolipoprotein A-I improves the regulatory T-cell response in autoimmune LDLr-/-, ApoA-I-/- mice [abstract]. Arterioscler Thromb Vasc Biol. 2010;30(11):e269.

Pendergrass KD, Gwathmey TM, Michalek RD, Grayson JM, Chappell MC. The angiotensin II-AT1 receptor stimulates reactive oxygen species within the cell nucleus. Biochem Biophys Res Commun. 2009;384(2):149-154.

Wilhelm AJ, Zabalawi M, Grayson JM, Weant AE, Major AS, Owen J, Bharadwaj M, Walzem R, Thomas MJ, Sorci-Thomas MG, et al. Apolipoprotein A-I and its role in lymphocyte cholesterol homeostasis and autoimmunity. Arterioscler Thromb Vasc Biol. 2009;29(6):843-849.

Wilhelm AJ, Zabalawi M, Grayson JM, Weant AE, Major AS, Owen JS, Thomas MJ, Sorci-Thomas MG. Apolipoprotein A-I: a common link between inflammation, atherosclerosis, and autoimmunity [abstract]. Arterioscler Thromb Vasc Biol. 2009;29(7):e13.

Pendergrass KD, Gwathmey TYM, Grayson JM, Chappell MC. Protein kinase C and PI3 kinase mediate Ang II-dependent generation of reactive oxygen species in renal nuclei [abstract]. FASEB J. 2009;23(1 Meeting Abstracts):803.7.

Weant AE, Michalek RD, Khan IU, Holbrook BC, Willingham MC, Grayson JM. Apoptosis regulators Bim and Fas function concurrently to control autoimmunity and CD8+ T cell contraction. Immunity. 2008;28(2):218-230.

Wilhelm AJ, Zabalawi M, Grayson J, Weant AE, Sorci-Thomas M. Absence of ApoA-I leads to dysregulation of lymph node immune cell cholesterol homeostasis and increased atherosclerosis in LDLr-/-, ApoA-I-/- mice [abstract]. Arterioscler Thromb Vasc Biol. 2008;28(6):e-65.

Michalek RD, Pellom ST, Holbrook BC, Grayson JM. The requirement of reactive oxygen intermediates for lymphocytic choriomeningitis virus binding and growth. Virology. 2008;379(2):205-212.

Pendergrass KD, Gwathmey TM, Michalek RD, Grayson JM, Chappell MC. Nuclear angiotensin II AT1 receptors mediate the formation of reactive oxygen species [abstract]. Hypertension. 2008;52(4):e48.

Constantin CM, Masopust D, Gourley T, Grayson J, Strickland OL, Ahmed R, Bonney EA. Normal establishment of virus-specific memory CD8 T cell pool following primary infection during pregnancy. J Immunol. 2007;179(7):4383-4389.

Michalek RD, Nelson KJ, Holbrook BC, Yi JS, Stridiron D, Daniel LW, Fetrow JS, King SB, Poole LB, Grayson JM. The requirement of reversible cysteine sulfenic acid formation for T cell activation and function. J Immunol. 2007;179(10):6456-6467.

Gamero AM, Potla R, Wegrzyn J, Szelag M, Edling AE, Shimoda K, Link DC, Dulak J, Baker DP, Grayson JM, et al. Activation of Tyk2 and Stat3 is required for the apoptotic actions of interferon-beta in primary pro-B cells. J Biol Chem. 2006;281(24):16238-44.

Yi JS, Holbrook BC, Michalek RD, Laniewski NG, Grayson JM. Electron transport complex I is required for CD8+ T cell function. J Immunol. 2006;177(2):852-862.

Grayson JM, Weant AE, Holbrook BC, Hildeman D. Role of Bim in regulating CD8+ T-cell responses during chronic viral infection. J Virol. 2006;80(17):8627-8638.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Microbiology & Immunology

Jason M. Grayson, Ph.D.

Jason M. Grayson, Ph.D.

Associate Professor, Microbiology & Immunology

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