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Leanne Groban, M.D.Wake Forest School of Medicine

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Leanne Groban, M.D.

Professor,




Clinical Interests

Cardiothoracic Anesthesia, Adult Cardiothoracic Anesthesia, Major Vascular Anesthesia, Myocardial Protection, Cardiac Aging, Diastolic Dysfunction

Contact Information

Department: 336-716-2011

Email: lgroban@wakehealth.edu

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Education & Training

  • B.S., University of Wisconsin-Madison, 1982
  • M.S., University of Wisconsin-Milwaukee, 1988
  • M.D., Medical College of Wisconsin, 1992
  • Internship, Anesthesiology, St Luke's Hosp, 1993
  • Residency, Anesthesiology, North Carolina Baptist Hospita, 1996
  • Fellowship, WFU School of Medicine, 1997

Board Certifications

  • American Board of Anesthesiology, Anesthesiology

Memberships

  • Alpha Omega Alpha

NPI Number

  • 1669457545
Leanne Groban, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

Leanne Groban, M.D.

Professor, Cardiothoracic Anesthesiology
Hypertension and Vascular Research Center
Office of Women in Medicine and Science
Sticht Center on Aging
Molecular Medicine

Research Interests

aging, cardiac function, fitness/physical, transgenics, women's health issues

Contact Information

Academic: 336-716-1187 | Department: 336-716-2011

Email: lgroban@wakehealth.edu

Recent Publications

Kim S, Brooks AK, Groban L. Preoperative assessment of the older surgical patient: honing in on geriatric syndromes. Clin Interv Aging. 2015;10():13-27.

Zhao Z, Wang H, Lin M, Groban L. GPR30 decreases cardiac chymase/angiotensin II by inhibiting local mast cell number. Biochem Biophys Res Commun. 2015;459(1):131-136.

Wang H, Zhao Z, Lin M, Groban L. Activation of GPR30 inhibits cardiac fibroblast proliferation. Mol Cell Biochem. 2015;405(1-2):135-148.

Nagata S, Varagic J, Kon ND, Wang H, Groban L, Simington SW, Ahmad S, Dell'Italia LJ, VonCannon JL, Deal D, Ferrario CM. Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue. Ther Adv Cardiovasc Dis. 2015;():.

Groban L, Kitzman DW, Register TC, Shively CA. Effect of depression and sertraline treatment on cardiac function in female nonhuman primates. Psychosom Med. 2014;76(2):137-146.

Zhao Z, Wang H, Jessup JA, Lindsey SH, Chappell MC, Groban L. Role of estrogen in diastolic dysfunction. Am J Physiol Heart Circ Physiol. 2014;306(5):H628-H640.

Ahmad S, Varagic J, Groban L, Dell'italia LJ, Nagata S, Kon ND, Ferrario CM. Angiotensin-(1-12): a chymase-mediated cellular angiotensin II substrate. Curr Hypertens Rep. 2014;16(5):429.

Ahmad S, Varagic J, VonCannon JL, Dell'Italia LJ, Groban L, Ferrario CM. Angiotensin-(1-12) is a better substrate compared to angiotensin I to generate angiotensin Ii by rat chymase [abstract]. Hypertension. 2014;64(Suppl 1):A622.

Moniwa N, Varagic J, Ahmad S, Voncannon JL, Simington SW, Wang H, Groban L, Brosnihan KB, Nagata S, Kato J, Kitamura K, Gomez RA, Lopez ML, Ferrario CM. Hemodynamic and hormonal changes to dual Renin-Angiotensin system inhibition in experimental hypertension. Hypertension. 2013;61(2):417-424.

Kim S, Edwards A, Rustowicz L, Roach C, Marsh A, Rejeski J, Kritchevsky S, Groban L. Do sex differences in preoperative mobility, nutrition, and frailty status predict length of hospital stay among older noncardiac surgical patients? [abstract]. J Am Geriatr Soc. 2013;61(Suppl 1):S127.

Laxton M, Porter J, Carter J, Roy R, Lagoo-Deenadayalan S, Groban L. Perioperative care of older patients: viewpoints from anesthesia and surgical residents [abstract]. In: Abstracts of the 39th Annual Meeting & Educational Leadership Conference of the Association for Gerontology in Higher Education; 2013 Feb 28 - Mar 3; St. Petersburg (FL). 2013;():97.

Jessup JA, Wang H, Macnamara LM, Presley TD, Kim-Shapiro DB, Zhang L, Chen AF, Groban L. Estrogen therapy, independent of timing, improves cardiac structure and function in oophorectomized mRen2.Lewis rats. Menopause. 2013;20(8):860-868.

Wang H, Jessup JA, Zhao Z, Da Silva J, Lin M, Macnamara LM, Ahmad S, Chappell MC, Ferrario CM, Groban L. Characterization of the cardiac renin angiotensin system in oophorectomized and estrogen-replete mRen2.Lewis rats. PLoS One. 2013;8(10):e76992.

Groban L, Kim S, Edwards A, Rustowicz L, Roach C, Marsh A, Rejeski J, Kritchevsky S. Sex differences in preoperative mobility, nutrition and frailty status predict hospital length of stay in older patients for noncardiac surgery [abstract]. In: Abstracts of the 2013 Annual Meeting of the American Society of Anesthesiologists (ASA); 2013 Oct 12-16; San Francisco (CA). 2013;():A3050.

Groban L, Wang H, Zhao Z, Jessup J, Lin M, MacNamara L, Ferrario CM. Estrogen replacement downregulates cardiac angiotensin II in an ACE-independent manner in oophorectomized mRen2.Lewis rats [abstract]. In: Abstracts of the 2013 Annual Meeting of the American Society of Anesthesiologists (ASA); 2013 Oct 12-16; San Francisco (CA). 2013;():A5002.

Wang H, Zhao Z, Jessup J, Lin M, MacNamara L, Ahmad S, Ferrario C, Groban L. Estrogen replacement downregulates cardiac angiotensin II in an ACE-independent manner in oophorectomized mRen2.Lewis rats [abstract]. Circ Res. 2013;113(4 Suppl):A086.

Nagata S, Varagic J, Simington SW, Ahmad S, VonCannon JL, Wang H, Groban L, Kon ND, Dell'Italia LJ, Ferrario CM. Differential expression of angiotensin-(1-12)/chymase in human atrial tissue [abstract]. Hypertension. 2013;62(3 Suppl):629.

Nagata S, Varagic J, Simington SW, Ahmad S, VonCannon JL, Wang H, Kon ND, Dell'Italia LJ, Ferrario CM, Groban L. Does cardiac ang-(1-12) have a role in sex-specific heart disease? [abstract]. Hypertension. 2013;62(3 Suppl):632.

Carter CS, Marzetti E, Leeuwenburgh C, Manini T, Foster TC, Groban L, Scarpace PJ, Morgan D. Usefulness of preclinical models for assessing the efficacy of late-life interventions for sarcopenia. J Gerontol A Biol Sci Med Sci. 2012;67(1):17-27.

Wang H, Jessup JA, Lin MS, Chagas C, Lindsey SH, Groban L. Activation of GPR30 attenuates diastolic dysfunction and left ventricle remodelling in oophorectomized mRen2.Lewis rats. Cardiovasc Res. 2012;94(1):96-104.

Groban L, Lindsey S, Wang H, Lin MS [sic] [Lin MR], Kassik KA, Machado FS, Carter CS. Differential effects of late-life initiation of low-dose enalapril and losartan on diastolic function in senescent Fischer 344 x Brown Norway male rats. Age (Dordr). 2012;34(4):831-843.

Groban L, Wang H, Machado FSM, Trask AJ, Kritchevsky SB, Ferrario CM, Diz DI. Low glial angiotensinogen improves body habitus, diastolic function, and exercise tolerance in aging male rats. Cardiovasc Endocrinol. 2012;1(3):49-58.

Delo DM, Guan X, Wang Z, Groban L, Callahan M, Smith T, Sane DC, Payne RM, Atala A, Soker S. Calcification after myocardial infarction is independent of amniotic fluid stem cell injection. Cardiovasc Pathol. 2011;20(2):e69-e78.

Sergeant S, McQuail JA, Riddle DR, Chilton FH, Ortmeier SB, Jessup JA, Groban L, Nicolle MM. Dietary fish oil modestly attenuates the effect of age on diastolic function but has no effect on memory or brain inflammation in aged rats. J Gerontol A Biol Sci Med Sci. 2011;66(5):521-533.

Royster RL, Groban L, Grosshans DW, Jones-Haywood M-M, Slaughter TF. Cardiovascular pharmacology In: Kaplan JA, Reich DL, Savino JS, eds. Kaplan's cardiac anesthesia: the echo era. 6th ed. St. Louis (MO): Saunders/Elsevier;2011: 235-295.

Groban L, Lin M, Kassik KA, Ingram RL, Sonntag WE. Early-onset growth hormone deficiency results in diastolic dysfunction in adult-life and is prevented by growth hormone supplementation. Growth Horm IGF Res. 2011;21(2):81-88.

Jessup JA, Zhang L, Chen AF, Presley TD, Kim-Shapiro DB, Chappell MC, Wang H, Groban L. Neuronal nitric oxide synthase inhibition improves diastolic function and reduces oxidative stress in ovariectomized mRen2.Lewis rats. Menopause. 2011;18(6):698-708.

Schafer AM, Rains JC, Penzien DB, Groban L, Smitherman TA, Houle TT. Direct costs of preventive headache treatments: comparison of behavioral and pharmacologic approaches. Headache. 2011;51(6):985-991.

Jessup JA, Zhang L, Presley TD, Kim-Shapiro DB, Wang H, Chen AF, Groban L. Tetrahydrobiopterin restores diastolic function and attenuates superoxide production in ovariectomized mRen2.Lewis rats. Endocrinology. 2011;152(6):2428-2436.

Whelan DM, Groban L. [Pulmonary arterial catheters] [Spanish] In: Rodriguez Villar S, ed. [Critical care protocols] [Spanish]. Madrid (Spain): Marban Libros;2011: 335-340.

Whelan DM, Groban L. [Arterial cannulation] [Spanish] In: Rodriguez Villar S, ed. [Critical care protocols] [Spanish]. Madrid (Spain): Marban Libros;2011: 331-334.

Whelan DM, Groban L. [Central venous access] [Spanish] In: Rodriguez Villar S, ed. [Critical care protocols] [Spanish]. Madrid (Spain): Marban Libros;2011: 321-324.

Kitzman DW, Groban L. Exercise intolerance. Cardiol Clin. 2011;29(3):461-477.

Bharadwaj MS, Strawn WB, Groban L, Yamaleyeva LM, Chappell MC, Horta C, Atkins K, Firmes L, Gurley SB, Brosnihan KB. Angiotensin-converting enzyme 2 deficiency is associated with impaired gestational weight gain and fetal growth restriction. Hypertension. 2011;58(5):852-858.

Diz DI, Garcia-Espinosa MA, Shaltout HA, Olson J, Bourland JD, Groban L. Correlation of the brain medullary metabolites N-acetyl aspartic acid and N-acetyl aspartyl glutamate with the age related decline in sensitivity for baroreflex control of heart rate in humans [abstract]. Hypertension. 2011;58(5):e116.

Yamaleyeva L, Bharadwaj M, Strawn W, Chappell M, Groban L, Atkins K, Horta C, Firmes L, Farah L, Gurly S, Brosnihan KB. ACE2 deficiency is associated with impaired gestational weight gain and fetal growth restriction [abstract]. Physiologist. 2011;54(6):22.

Varagic J, Ahmad S, Brosnihan KB, Groban L, Chappell MC, Tallant EA, Gallagher PE, Ferrario CM. Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction. Ther Adv Cardiovasc Dis. 2010;4(1):17-25.

Groban L, Sanders DM, Houle TT, Antonio BL, Ntuen EC, Zvara DA, Kon ND, Kincaid EH. Prognostic value of tissue Doppler-derived E/e' on early morbid events after cardiac surgery. Echocardiography. 2010;27(2):131-138.

Trask AJ, Groban L, Westwood BM, Varagic J, Ganten D, Gallagher PE, Chappell MC, Ferrario CM. Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats. Am J Hypertens. 2010;23(6):687-693.

Groban L, Kitzman DW. Diastolic function: a barometer for cardiovascular risk? [editorial]. Anesthesiology. 2010;112(6):1303-1306.

Groban L, Jessup J, Register T. Early estrogen replacement prevents lusitropic impairment following ovariectomy in middle-aged cynomolgus monkeys [abstract]. J Am Coll Cardiol. 2010;55(10A):A38.

Brock MF, Grace BE, Morley B, Hillegass G, Houle TT, Groban L. Does lidocaine more effectively prevent pain upon induction with propofol or etomidate when given preemptively than when mixed with the drug?. J Clin Anesth. 2010;22(7):505-509.

Jessup JA, Lindsey SH, Wang H, Chappell MC, Groban L. Attenuation of salt-induced cardiac remodeling and diastolic dysfunction by the GPER agonist G-1 in female mRen2.Lewis rats. PLoS ONE. 2010;5(11):e15433.

Dudley M, Groban L. Cardiovascular changes in the elderly and their anesthetic implications [CME]. Curr Rev Clin Anesth. 2009;29(22):261-276.

Petersen RP, Heflin MT, Groban L, Lagoo-Deenadayalan SA. Surgery residents desire more training in geriatric care [abstract]. J Am Geriatr Soc. 2009;57(Suppl 1):S111-S112.

Jessup JA, Westwood BM, Chappell MC, Groban L. Dual ACE-inhibition and AT1 receptor antagonism improves ventricular lusitropy without affecting cardiac fibrosis in the congenic mRen2.Lewis rat. Ther Adv Cardiovasc Dis. 2009;3(4):245-257.

Groban L, Butterworth J. Fentanyl: destiny or devil? [editorial]. Anesth Analg. 2009;109(2):301-302.

Groban L, Lin MR, Jessup JA, Chappell MC, Brunso-Bechtold JK. GH repletion increases intracardiac Ang-1-7/ACE2 and restores diastolic function in aged male BNF344 rats [abstract]. J Card Fail. 2009;15(6 Suppl 1):S33-S34.

Jessup JA, Lindsey SH, Chappell MC, Groban L. GPR30 receptor activation improves cardiac function in intact female mRen2.Lewis rats [abstract]. J Card Fail. 2009;15(6 Suppl 1):S75.

Sanders D, Dudley M, Groban L. Diastolic dysfunction, cardiovascular aging, and the anesthesiologist. Anesthesiol Clin. 2009;27(3):497-517.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Cardiothoracic Anesthesiology

Clinical Interests

Cardiothoracic Anesthesia, Adult Cardiothoracic Anesthesia, Major Vascular Anesthesia, Myocardial Protection, Cardiac Aging, Diastolic Dysfunction

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