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Leanne Groban, M.D.Wake Forest School of Medicine

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Leanne Groban, M.D.

Professor,

Clinical Interests

Cardiothoracic Anesthesia, Adult Cardiothoracic Anesthesia, Major Vascular Anesthesia, Myocardial Protection, Cardiac Aging, Diastolic Dysfunction

Contact Information

Email: lgroban@wakehealth.edu

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Education & Training

  • B.S., University of Wisconsin-Madison, 1982
  • M.S., University of Wisconsin-Milwaukee, 1988
  • M.D., Medical College of Wisconsin, 1992
  • Internship, Anesthesiology, St Luke's Hosp, 1993
  • Residency, Anesthesiology, NC Baptist Hospital, 1996
  • Fellowship, WFU School of Medicine, 1997

Memberships

  • Alpha Omega Alpha

NPI Number

  • 1669457545
Leanne Groban, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

Leanne Groban, M.D.

Professor, Anesthesiology
Office of Women in Medicine and Science

Research Interests

Diastole; Receptors, G-Protein-Coupled; Myocardium; Heart; Estrogens
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Contact Information

Academic: 336-716-1187

Email: lgroban@wakehealth.edu

Recent Publications

Effect of age, estrogen status, and late-life GPER activation on cardiac structure and function in the Fischer344xBrown Norway female rat. Alencar AK, da Silva JS, Lin M, Silva AM, Sun X, Ferrario CM, Cheng C, Sudo RT, Zapata-Sudo G, Wang H, Groban L.. J Gerontol A Biol Sci Med Sci. 2017;72(2):152-162.

Cardiomyocyte-specific deletion of the G protein-coupled estrogen receptor (GPER) leads to left ventricular dysfunction and adverse remodeling: a sex-specific gene profiling analysis. Wang H, Sun X, Chou J, Lin M, Ferrario CM, Zapata-Sudo G, Groban L.. Biochim Biophys Acta. 2017;1863(8):1870-1882.

Novel cardiac intracrine mechanisms based on Ang-(1-12)/chymase axis require a revision of therapeutic approaches in human heart disease. Reyes S, Varagic J, Ahmad S, VonCannon J, Kon ND, Wang H, Groban L, Cheng CP, Dell'Italia LJ, Ferrario CM.. Curr Hypertens Rep. 2017;19(2):16.

Adenosine A2A receptor agonist prevents cardiac remodeling and dysfunction in spontaneously hypertensive male rats after myocardial infarction. da Silva JS, Gabriel-Costa D, Sudo RT, Wang H, Groban L, Ferraz EB, Nascimento JH, Fraga CA, Barreiro EJ, Zapata-Sudo G.. Drug Des Devel Ther. 2017;11():553-562.

Cardiovascular pharmacology. Royster RL, Groban L, Locke AQ, Morris BN, Slaughter TF. In: Kaplan JA, Augoustides JGT, Manecke GR, Maus T Jr, Reich DL, eds. Kaplan's cardiac anesthesia: for cardiac and noncardiac surgery. 7th ed. Philadelphia (PA): Elsevier;2017: 292-354.

Long-term sertraline treatment and depression effects on carotid artery atherosclerosis in premenopausal female primates. Silverstein-Metzler MG, Justice JN, Appt SE, Groban L, Kitzman DW, Carr JJ, Register TC, Shively CA.. Menopause. 2017;24(10):1175-1184.

Pharmacological evaluation of the agonists of nuclear and G protein coupled estrogen receptors in arterial hypertension associated with estrogen depletion [abstract]. Zapata-Sudo G, Da Silva JS, Da Silva AM, Montagnoli TL, Wang H, Sun X, Groban L, Sudo RT.. Eur J Heart Fail. 2017;19(Suppl 1):340.

Activation of a new estrogen receptor (GPER) ameliorates cardiopulmonary dysfunction in female rats with pulmonary hypertension [abstract]. Zapata-Sudo G, De Alencar AKN, Da Silva AM, Montes GC, Montagnoli TL, Martinez S, Villarinho L, Cunha VN, Fraga A, Wang H, Groban L, Fraga CAM, Sudo RT.. Eur J Heart Fail. 2017;19(Suppl 1):519.

Blunting of cardioprotective actions of estrogen in female rodent heart linked to altered expression of cardiac tissue chymase and ACE2. da Silva JS, Gabriel-Costa D, Wang H, Ahmad S, Sun X, Varagic J, Sudo RT, Ferrario CM, Dell Italia LJ, Sudo GZ, Groban L.. J Renin Angiotensin Aldosterone Syst. 2017;18(3):.

Blunting of estrogen modulation of cardiac cellular chymase/RAS activity and function in SHR. Ahmad S, Sun X, Lin M, Varagic J, Zapata-Sudo G, Ferrario CM, Groban L, Wang H.. J Cell Physiol. 2017;():.

Cardiac angiotensin-(1-12) expression and systemic hypertension in rats expressing the human angiotensinogen gene. Ferrario CM, VonCannon JL, Jiao Y, Ahmad S, Bader M, Dell'Italia LJ, Groban L, Varagic J.. Am J Physiol Heart Circ Physiol. 2016;310(8):H995-H1002.

Mast cell inhibition attenuates cardiac remodeling and diastolic dysfunction in middle-aged, ovariectomized Fischer 344 x Brown Norway rats. Wang H, da Silva J, Alencar A, Zapata-Sudo G, Lin MS, Sun X, Ahmad S, Ferrario CM, Groban L.. J Cardiovasc Pharmacol. 2016;68(1):49-57.

Self-reported mobility in older patients predicts early postoperative outcomes after elective noncardiac surgery. Kim S, Marsh AP, Rustowicz L, Roach C, Leng XI, Kritchevsky SB, Rejeski WJ, Groban L.. Anesthesiology. 2016;124(4):815-825.

Activation of GPR30 improves exercise capacity and skeletal muscle strength in senescent female Fischer344 x Brown Norway rats. Wang H, Alencar A, Lin M, Sun X, Sudo RT, Zapata-Sudo G, Lowe DA, Groban L.. Biochem Biophys Res Commun. 2016;475(1):81-86.

Intracrine angiotensin II functions originate from noncanonical pathways in the human heart. Ferrario CM, Ahmad S, Varagic J, Cheng CP, Groban L, Wang H, Collawn JF, Dell'Italia LJ.. Am J Physiol Heart Circ Physiol. 2016;311(2):H404-H414.

Primacy of cardiac chymase over angiotensin converting enzyme as an angiotensin-(1-12) metabolizing enzyme. Ahmad S, Varagic J, VonCannon JL, Groban L, Collawn JF, Dell'Italia LJ, Ferrario CM.. Biochem Biophys Res Commun. 2016;478(2):559-564.

Activation of GPER ameliorates experimental pulmonary hypertension in male rats. Alencar AK, Montes GC, Montagnoli T, Silva AM, Martinez ST, Fraga AG, Wang H, Groban L, Sudo RT, Zapata-Sudo G.. Eur J Pharm Sci. 2016;97():208-217.

Inflammatory and mitochondrial gene expression data in GPER-deficient cardiomyocytes from male and female mice. Wang H, Sun X, Chou J, Lin M, Ferrario CM, Zapata-Sudo G, Groban L.. Data Brief. 2016;10():465-473.

Chronic GPER activation attenuates cardiac dysfunction in a male mouse model of progressive heart failure: insights into cellular mechanisms [abstract]. Zhang X, Li T, Wang H, Cheng H-J, Li W, Ferrario CM, Groban L, Cheng C-P.. Circulation. 2016;134(Suppl 1):A12559.

Altered cardiomyocyte inotropic response to chymase/Ang-(1-12) pathway activation in heart failure [abstract]. Li T, Zhang X, Ahmad S, Varagic J, Cheng H-J, Zhang Z, Groban L, Ferrario CM, Cheng C-P.. Circulation. 2016;134(Suppl 1):A12206.

Reversal of aging-induced upregulation of cardiac inducible nitric oxide synthase and beta-adrenergic desensitization in mice deficient in beta3-adrenoreceptor [abstract]. Cheng H-J, Zhou P, Li T, Zhang Z, Kitzman DW, Gorban L, Cheng C-P.. Circulation. 2016;134(Suppl 1):A14375.

Preoperative assessment of the older surgical patient: honing in on geriatric syndromes. Kim S, Brooks AK, Groban L.. Clin Interv Aging. 2015;10():13-27.

GPR30 decreases cardiac chymase/angiotensin II by inhibiting local mast cell number. Zhao Z, Wang H, Lin M, Groban L.. Biochem Biophys Res Commun. 2015;459(1):131-136.

Activation of GPR30 inhibits cardiac fibroblast proliferation. Wang H, Zhao Z, Lin M, Groban L.. Mol Cell Biochem. 2015;405(1-2):135-148.

Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue. Nagata S, Varagic J, Kon ND, Wang H, Groban L, Simington SW, Ahmad S, Dell'Italia LJ, VonCannon JL, Deal D, Ferrario CM.. Ther Adv Cardiovasc Dis. 2015;9(4):168-180.

Augmentation of autophagy by atorvastatin via Akt/mTOR pathway in spontaneously hypertensive rats. Wang W, Wang H, Geng QX, Wang HT, Miao W, Cheng B, Zhao D, Song GM, Leanne G, Zhao Z.. Hypertens Res. 2015;38(12):813-820.

Chronic activation of GPR30 attenuates diastolic dysfunction in oophorectomized senescent rats [abstract]. Groban L, Kardec A, Wang H, da Silva J, Lin MS, Sun X.. In: Abstracts of the 2015 Annual Meeting of the American Society of Anesthesiologists (ASA); 2015 Oct 24-28; San Diego (CA). 2015;():A1265.

Mast cell inhibition attenuates cardiac remodeling and diastolic dysfunction in ovariectomized BNF344 female rats [abstract]. Groban L, Wang H, da Silva J, Kardec A, Lin MS, Sun X.. In: Abstracts of the 2015 Annual Meeting of the American Society of Anesthesiologists (ASA); 2015 Oct 24-28; San Diego (CA). 2015;():A1273.

Anatomic and physiopathologic changes affecting the airway of the elderly patient: implications for geriatric-focused airway management. Johnson KN, Botros DB, Groban L, Bryan YF.. Clin Interv Aging. 2015;10():1925-1934.

Functional significance of the chymase/ang-(1-12) pathway on cardiomyocytes [abstract]. Zhang X, Li T, Ahmad S, Varagic J, Groban L, Dell'Italia LJ, Cheng C-P, Ferrario CM.. Hypertension. 2015;66(Suppl 1):A078.

Distinct profiles of brain medullary metabolites detected by 1H-magnetic resonance spectroscopy correlate with indices of autonomic function and visceral fat in healthy adults [abstract]. Diz DI, Olson J, Bourland JD, Kitzman D, Carr JJ, Kritchevsky SB, Groban L, Shaltout HA.. Hypertension. 2015;66(Suppl 1):AP149.

Late-life activation of GPR30 by G1 reverses diastolic dysfunction in senescent BNF344 female rats [abstract]. Kardec A, Wang H, da Silva J, Lin M, Sun X, Groban L.. Gerontologist. 2015;55(Suppl 2):68.

How well does the NSQIP surgical calculator predict early adverse outcomes in older non-cardiac surgical patients with self-reported limitations in mobility? [abstract]. Harris C, Kim S, Groban L.. Gerontologist. 2015;55(Suppl 2):192.

GPR30 activation improves exercise capacity and skeletal muscle function in senescent female F344BN rats [abstract]. Wang H, Kardec A, Lin M, Sun X, Groban L.. Gerontologist. 2015;55(Suppl 2):105.

Late-life activation of GPR30 by G1 reverses diastolic dysfunction in senescent Fischer344 x Brown Norway female rats [abstract]. Alencar A, Wang H, de Silva J, Lin M, Sun XM, Groban L.. Circ Res. 2015;117(Suppl 1):A351.

Mast cell inhibition attenuates cardiac remodeling and diastolic dysfunction in ovariectomized female Fischer344.Brown Norway Rats [abstract]. Wang H, da Silva J, Alencar A, Lin M, Sun XM, Groban L.. Circ Res. 2015;117(Suppl 1):353.

Mast cell inhibition attenuates cardiac remodeling and diastolic dysfunction in ovariectomized BNF344 female rats [abstract]. Wang H, Da Silva J, Kardec A, Lin M, Sun X, Groban L.. Gerontologist. 2015;55(Suppl 2):69.

Effect of depression and sertraline treatment on cardiac function in female nonhuman primates. Groban L, Kitzman DW, Register TC, Shively CA.. Psychosom Med. 2014;76(2):137-146.

Role of estrogen in diastolic dysfunction. Zhao Z, Wang H, Jessup JA, Lindsey SH, Chappell MC, Groban L.. Am J Physiol Heart Circ Physiol. 2014;306(5):H628-H640.

Angiotensin-(1-12): a chymase-mediated cellular angiotensin II substrate. Ahmad S, Varagic J, Groban L, Dell'italia LJ, Nagata S, Kon ND, Ferrario CM.. Curr Hypertens Rep. 2014;16(5):429.

Angiotensin-(1-12) is a better substrate compared to angiotensin I to generate angiotensin Ii by rat chymase [abstract]. Ahmad S, Varagic J, VonCannon JL, Dell'Italia LJ, Groban L, Ferrario CM.. Hypertension. 2014;64(Suppl 1):A622.

Hemodynamic and hormonal changes to dual Renin-Angiotensin system inhibition in experimental hypertension. Moniwa N, Varagic J, Ahmad S, Voncannon JL, Simington SW, Wang H, Groban L, Brosnihan KB, Nagata S, Kato J, Kitamura K, Gomez RA, Lopez ML, Ferrario CM.. Hypertension. 2013;61(2):417-424.

Do sex differences in preoperative mobility, nutrition, and frailty status predict length of hospital stay among older noncardiac surgical patients? [abstract]. Kim S, Edwards A, Rustowicz L, Roach C, Marsh A, Rejeski J, Kritchevsky S, Groban L.. J Am Geriatr Soc. 2013;61(Suppl 1):S127.

Perioperative care of older patients: viewpoints from anesthesia and surgical residents [abstract]. Laxton M, Porter J, Carter J, Roy R, Lagoo-Deenadayalan S, Groban L.. In: Abstracts of the 39th Annual Meeting & Educational Leadership Conference of the Association for Gerontology in Higher Education; 2013 Feb 28 - Mar 3; St. Petersburg (FL). 2013;():97.

Estrogen therapy, independent of timing, improves cardiac structure and function in oophorectomized mRen2.Lewis rats. Jessup JA, Wang H, Macnamara LM, Presley TD, Kim-Shapiro DB, Zhang L, Chen AF, Groban L.. Menopause. 2013;20(8):860-868.

Characterization of the cardiac renin angiotensin system in oophorectomized and estrogen-replete mRen2.Lewis rats. Wang H, Jessup JA, Zhao Z, Da Silva J, Lin M, Macnamara LM, Ahmad S, Chappell MC, Ferrario CM, Groban L.. PLoS One. 2013;8(10):e76992.

Sex differences in preoperative mobility, nutrition and frailty status predict hospital length of stay in older patients for noncardiac surgery [abstract]. Groban L, Kim S, Edwards A, Rustowicz L, Roach C, Marsh A, Rejeski J, Kritchevsky S.. In: Abstracts of the 2013 Annual Meeting of the American Society of Anesthesiologists (ASA); 2013 Oct 12-16; San Francisco (CA). 2013;():A3050.

Estrogen replacement downregulates cardiac angiotensin II in an ACE-independent manner in oophorectomized mRen2.Lewis rats [abstract]. Groban L, Wang H, Zhao Z, Jessup J, Lin M, MacNamara L, Ferrario CM.. In: Abstracts of the 2013 Annual Meeting of the American Society of Anesthesiologists (ASA); 2013 Oct 12-16; San Francisco (CA). 2013;():A5002.

Estrogen replacement downregulates cardiac angiotensin II in an ACE-independent manner in oophorectomized mRen2.Lewis rats [abstract]. Wang H, Zhao Z, Jessup J, Lin M, MacNamara L, Ahmad S, Ferrario C, Groban L.. Circ Res. 2013;113(4 Suppl):A086.

Differential expression of angiotensin-(1-12)/chymase in human atrial tissue [abstract]. Nagata S, Varagic J, Simington SW, Ahmad S, VonCannon JL, Wang H, Groban L, Kon ND, Dell'Italia LJ, Ferrario CM.. Hypertension. 2013;62(3 Suppl):629.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Anesthesiology

Clinical Interests

Cardiothoracic Anesthesia, Adult Cardiothoracic Anesthesia, Major Vascular Anesthesia, Myocardial Protection, Cardiac Aging, Diastolic Dysfunction

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