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Roy R. Hantgan, Ph.D.

Roy R. Hantgan, Ph.D.

Associate Professor, Biochemistry
Molecular Medicine
Contact Information
Office:
336-716-2011
Email: rhantgan@wakehealth.edu
Education & Training
  BSJuniata College1968
  PhDCornell University1974
FellowshipNational Institutes Hlth1977
Memberships
American Association of Advancement of Science
Aha - Thrombosis Council
Biophysics Society
International Fibrinogen Research Society
Int'L Society of Thrombosis & Hemostasis
Roy R. Hantgan, Ph.D.

Roy R. Hantgan, Ph.D.

Associate Professor, Biochemistry
Molecular Medicine
Contact Information
Office:
336-716-2011
Email: rhantgan@wakehealth.edu
Research Interests
molecular biology/molecular me , rare diseases , vascular diseases
Recent Publications
Giri B, Smaldino PJ, Thys RG, Creacy SD, Routh ED, Hantgan RR, Lattmann S, Nagamine Y, Akman SA, Vaughn JP. G4 Resolvase 1 tightly binds and unwinds unimolecular G4-DNA. Nucleic Acids Res. 2011; 39(16):7161-7178.


Riedel TJ, Johnson LC, Knight J, Hantgan RR, Holmes RP, Lowther WT. Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria. PLoS ONE. 2011; 6(10):e26021.


Hantgan RR, Stahle MC, Lord ST. Dynamic regulation of fibrinogen: integrin alpha IIb beta3 binding. Biochemistry. 2010; 49(43):9217-9225.


Mizel SB, Graff AH, Sriranganathan N, Ervin S, Lees CJ, Lively MO, Hantgan RR, Thomas MJ, Wood J, Bell B. Flagellin-F1-V fusion protein is an effective plague vaccine in mice and two species of nonhuman primates. Clin Vaccine Immunol. 2009; 16(1):21-28.


Hantgan RR, Stahle MC. Integrin priming dynamics: mechanisms of integrin antagonist-promoted alphaIIbbeta3:PAC-1 molecular recognition. Biochemistry. 2009; 48(35):8355-8365.


Tsurupa G, Hantgan RR, Burton RA, Pechik I, Tjandra N, Medved L. Structure, stability, and interaction of the fibrin(ogen) alphaC-domains. Biochemistry. 2009; 48(51):12191-201.


Hantgan RR, Stahle MC, Horita DA. Entropy drives integrin alpha IIb beta 3 : echistatin binding--evidence from surface plasmon resonance spectroscopy. Biochemistry. 2008; 47(9):2884-2892.


Azarov I, He X, Jeffers A, Basu S, Ucer B, Hantgan RR, Levy A, Kim-Shapiro DB. Rate of nitric oxide scavenging by hemoglobin bound to haptoglobin. Nitric Oxide. 2008; 18(4):296-302.


Hantgan RR, Stahle MC, Grant K, Horita DA. PAC-1 binding illuminates integrin priming mechanisms [abstract]. Arterioscler Thromb Vasc Biol. 2008; 28(6):e-139.


Rocco M, Rosano C, Weisel JW, Horita DA, Hantgan RR. Integrin conformational regulation: uncoupling extension/tail separation from changes in the head region by a multiresolution approach. Structure. 2008; 16(6):954-964.


Shen K, Sergeant S, Hantgan RR, McPhail LC, Horita DA. Mutations in the PX-SH3A linker of p47phox decouple PI(3,4)P2 binding from NADPH oxidase activation. Biochemistry. 2008; 47(34):8855-8865.


Hantgan RR, Stahle MC, Connor JH, Connor RF, Mousa SA. AlphaIIb beta3 priming and clustering by orally active and intravenous integrin antagonists. J Thromb Haemost. 2007; 5(3):542-550.


Hantgan RR, Stahle MC. Entropy drives alpha IIb beta 3 integrin: ligand binding and oligomerization [abstract]. Biophys J. 2007; (Suppl):367a.


Burton RA, Tsurupa G, Hantgan RR, Tjandra N, Medved L. NMR solution structure, stability, and interaction of the recombinant bovine fibrinogen alphaC-domain fragment. Biochemistry. 2007; 46(29):8550-8560.


Guthold M, Liu W, Sparks EA, Jawerth LM, Peng L, Falvo M, Superfine R, Hantgan RR, Lord ST. A comparison of the mechanical and structural properties of fibrin fibers with other protein fibers. Cell Biochem Biophys. 2007; 49(3):165-181.


Hantgan RR, Stahle MC, Connor JH, Horita DA, Rocco M, McLane MA, Yakovlev S, Medved L. Integrin alphaIIbbeta3:ligand interactions are linked to binding-site remodeling. Protein Sci. 2006; 15(8):1893-1906.


Liu W, Jawerth LM, Sparks EA, Falvo MR, Hantgan RR, Superfine R, Lord ST, Guthold M. Fibrin fibers have extraordinary extensibility and elasticity. Science. 2006; 313(5787):634.


Levi N, Hantgan RR, Lively MO, Carroll DL, Prasad GL. C60-Fullerenes: detection of intracellular photoluminescence and lack of cytotoxic effects. J Nanobiotechnol. 2006; 4():article 14.
All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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Last Updated 1/5/2012
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