Roy R. Hantgan, Ph.D., Associate Professor Biochemistry

Roy R. Hantgan, Ph.D.

Associate Professor, Biochemistry

Contact Information

Academic: 336-716-4675 | Department: 336-716-2011

Email: rhantgan@wakehealth.edu

Education & Training

Ph.D., Cornell University , 1974
B.S., Juniata College , 1968
Fellowship, National Institutes Hlth, 1977

Memberships

Am Assn Of Advancement Of Scie
Aha - Thrombosis Council
Biophysics Society
Int'l Fibrinogen Research Soc
Int'L Soc Of Thrombosis & Hemo

Roy R. Hantgan, Ph.D.

Associate Professor, Biochemistry

Research Interests

atherosclerosis/thrombosis, drugs/therapeutic agents pharm, molecular biology/molecular me

Contact Information

Academic: 336-716-4675 | Department: 336-716-2011

Email: rhantgan@wakehealth.edu

Recent Publications

Rahmany MB, Hantgan RR, Van Dyke M. A mechanistic investigation of the effect of keratin-based hemostatic agents on coagulation. Biomaterials. 2013;34(10):2492-2500.

Tsurupa G, Pechik I, Litvinov RI, Hantgan RR, Tjandra N, Weisel JW, Medved L. On the mechanism of alphaC polymer formation in fibrin. Biochemistry. 2012;51(12):2526-2538.

Lema Tome CM, Palma E, Ferlaga S, Lowther WT, Hantgan R, Wykosky J, Debinski W. Structural and functional characterization of monomeric EphrinA1 binding site to EphA2 receptor. J Biol Chem. 2012;287(17):14012-22.

Nguyen V, Conyers JM, Zhu D, Gibo DM, Hantgan RR, Larson SM, Debinski W, Mintz A. A novel ligand delivery system to non-invasively visualize and therapeutically exploit the IL13R alpha2 tumor-restricted biomarker. Neuro Oncol. 2012;14(10):1239-1253.

Helms CC, Marvel M, Stahle M, Hantgan RR, Kato GJ, Lee JS, Gladwin M, Kim-Shapiro DB. The role of free radicals in hemolysis associated platelet activation [abstract]. Free Radic Biol Med. 2012;53(Suppl 2):S162-S163.

Giri B, Smaldino PJ, Thys RG, Creacy SD, Routh ED, Hantgan RR, Lattmann S, Nagamine Y, Akman SA, Vaughn JP. G4 Resolvase 1 tightly binds and unwinds unimolecular G4-DNA. Nucleic Acids Res. 2011;39(16):7161-7178.

Riedel TJ, Johnson LC, Knight J, Hantgan RR, Holmes RP, Lowther WT. Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria. PLoS ONE. 2011;6(10):e26021.

Hantgan RR, Stahle MC, Lord ST. Dynamic regulation of fibrinogen: integrin alpha IIb beta3 binding. Biochemistry. 2010;49(43):9217-9225.

Mizel SB, Graff AH, Sriranganathan N, Ervin S, Lees CJ, Lively MO, Hantgan RR, Thomas MJ, Wood J, Bell B. Flagellin-F1-V fusion protein is an effective plague vaccine in mice and two species of nonhuman primates. Clin Vaccine Immunol. 2009;16(1):21-28.

Hantgan RR, Stahle MC. Integrin priming dynamics: mechanisms of integrin antagonist-promoted alphaIIbbeta3:PAC-1 molecular recognition. Biochemistry. 2009;48(35):8355-8365.

Tsurupa G, Hantgan RR, Burton RA, Pechik I, Tjandra N, Medved L. Structure, stability, and interaction of the fibrin(ogen) alphaC-domains. Biochemistry. 2009;48(51):12191-201.

Hantgan RR, Stahle MC, Horita DA. Entropy drives integrin alpha IIb beta 3 : echistatin binding--evidence from surface plasmon resonance spectroscopy. Biochemistry. 2008;47(9):2884-2892.

Azarov I, He X, Jeffers A, Basu S, Ucer B, Hantgan RR, Levy A, Kim-Shapiro DB. Rate of nitric oxide scavenging by hemoglobin bound to haptoglobin. Nitric Oxide. 2008;18(4):296-302.

Hantgan RR, Stahle MC, Grant K, Horita DA. PAC-1 binding illuminates integrin priming mechanisms [abstract]. Arterioscler Thromb Vasc Biol. 2008;28(6):e-139.

Rocco M, Rosano C, Weisel JW, Horita DA, Hantgan RR. Integrin conformational regulation: uncoupling extension/tail separation from changes in the head region by a multiresolution approach. Structure. 2008;16(6):954-964.

Shen K, Sergeant S, Hantgan RR, McPhail LC, Horita DA. Mutations in the PX-SH3A linker of p47phox decouple PI(3,4)P2 binding from NADPH oxidase activation. Biochemistry. 2008;47(34):8855-8865.

Hantgan RR, Stahle MC, Connor JH, Connor RF, Mousa SA. AlphaIIb beta3 priming and clustering by orally active and intravenous integrin antagonists. J Thromb Haemost. 2007;5(3):542-550.

Hantgan RR, Stahle MC. Entropy drives alpha IIb beta 3 integrin: ligand binding and oligomerization [abstract]. Biophys J. 2007;(Suppl):367a.

Burton RA, Tsurupa G, Hantgan RR, Tjandra N, Medved L. NMR solution structure, stability, and interaction of the recombinant bovine fibrinogen alphaC-domain fragment. Biochemistry. 2007;46(29):8550-8560.

Guthold M, Liu W, Sparks EA, Jawerth LM, Peng L, Falvo M, Superfine R, Hantgan RR, Lord ST. A comparison of the mechanical and structural properties of fibrin fibers with other protein fibers. Cell Biochem Biophys. 2007;49(3):165-181.

Hantgan RR, Stahle MC, Connor JH, Horita DA, Rocco M, McLane MA, Yakovlev S, Medved L. Integrin alphaIIbbeta3:ligand interactions are linked to binding-site remodeling. Protein Sci. 2006;15(8):1893-1906.

Liu W, Jawerth LM, Sparks EA, Falvo MR, Hantgan RR, Superfine R, Lord ST, Guthold M. Fibrin fibers have extraordinary extensibility and elasticity. Science. 2006;313(5787):634.

Levi N, Hantgan RR, Lively MO, Carroll DL, Prasad GL. C60-Fullerenes: detection of intracellular photoluminescence and lack of cytotoxic effects. J Nanobiotechnol. 2006;4():article 14.