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Roy R. Hantgan, Ph.D.

Roy R. Hantgan, Ph.D.

Associate Professor, Biochemistry

Contact Information

Academic: 336-716-4675 | Department: 336-716-2011

Email: rhantgan@wakehealth.edu

Education & Training

  • Ph.D., Cornell University , 1974
  • B.S., Juniata College , 1968
  • Fellowship, National Institutes Hlth, 1977

Memberships

  • Am Assn Of Advancement Of Scie
  • Aha - Thrombosis Council
  • Biophysics Society
  • Int'l Fibrinogen Research Soc
  • Int'L Soc Of Thrombosis & Hemo
Roy R. Hantgan, Ph.D.

Roy R. Hantgan, Ph.D.

Associate Professor, Biochemistry

Research Interests

atherosclerosis/thrombosis, drugs/therapeutic agents pharm, molecular biology/molecular me

Contact Information

Academic: 336-716-4675 | Department: 336-716-2011

Email: rhantgan@wakehealth.edu

Recent Publications

Rahmany MB, Hantgan RR, Van Dyke M. A mechanistic investigation of the effect of keratin-based hemostatic agents on coagulation. Biomaterials. 2013;34(10):2492-2500.

Burnett LR, Rahmany MB, Richter JR, Aboushwareb TA, Eberli D, Ward CL, Orlando G, Hantgan RR, Van Dyke ME. Hemostatic properties and the role of cell receptor recognition in human hair keratin protein hydrogels. Biomaterials. 2013;34(11):2632-2640.

Tsurupa G, Pechik I, Litvinov RI, Hantgan RR, Tjandra N, Weisel JW, Medved L. On the mechanism of alphaC polymer formation in fibrin. Biochemistry. 2012;51(12):2526-2538.

Lema Tome CM, Palma E, Ferlaga S, Lowther WT, Hantgan R, Wykosky J, Debinski W. Structural and functional characterization of monomeric EphrinA1 binding site to EphA2 receptor. J Biol Chem. 2012;287(17):14012-22.

Nguyen V, Conyers JM, Zhu D, Gibo DM, Hantgan RR, Larson SM, Debinski W, Mintz A. A novel ligand delivery system to non-invasively visualize and therapeutically exploit the IL13R alpha2 tumor-restricted biomarker. Neuro Oncol. 2012;14(10):1239-1253.

Helms CC, Marvel M, Stahle M, Hantgan RR, Kato GJ, Lee JS, Gladwin M, Kim-Shapiro DB. The role of free radicals in hemolysis associated platelet activation [abstract]. Free Radic Biol Med. 2012;53(Suppl 2):S162-S163.

Giri B, Smaldino PJ, Thys RG, Creacy SD, Routh ED, Hantgan RR, Lattmann S, Nagamine Y, Akman SA, Vaughn JP. G4 Resolvase 1 tightly binds and unwinds unimolecular G4-DNA. Nucleic Acids Res. 2011;39(16):7161-7178.

Riedel TJ, Johnson LC, Knight J, Hantgan RR, Holmes RP, Lowther WT. Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria. PLoS ONE. 2011;6(10):e26021.

Hantgan RR, Stahle MC, Lord ST. Dynamic regulation of fibrinogen: integrin alpha IIb beta3 binding. Biochemistry. 2010;49(43):9217-9225.

Mizel SB, Graff AH, Sriranganathan N, Ervin S, Lees CJ, Lively MO, Hantgan RR, Thomas MJ, Wood J, Bell B. Flagellin-F1-V fusion protein is an effective plague vaccine in mice and two species of nonhuman primates. Clin Vaccine Immunol. 2009;16(1):21-28.


Tsurupa G, Hantgan RR, Burton RA, Pechik I, Tjandra N, Medved L. Structure, stability, and interaction of the fibrin(ogen) alphaC-domains. Biochemistry. 2009;48(51):12191-201.


Azarov I, He X, Jeffers A, Basu S, Ucer B, Hantgan RR, Levy A, Kim-Shapiro DB. Rate of nitric oxide scavenging by hemoglobin bound to haptoglobin. Nitric Oxide. 2008;18(4):296-302.

Hantgan RR, Stahle MC, Grant K, Horita DA. PAC-1 binding illuminates integrin priming mechanisms [abstract]. Arterioscler Thromb Vasc Biol. 2008;28(6):e-139.


Shen K, Sergeant S, Hantgan RR, McPhail LC, Horita DA. Mutations in the PX-SH3A linker of p47phox decouple PI(3,4)P2 binding from NADPH oxidase activation. Biochemistry. 2008;47(34):8855-8865.

Hantgan RR, Stahle MC, Connor JH, Connor RF, Mousa SA. AlphaIIb beta3 priming and clustering by orally active and intravenous integrin antagonists. J Thromb Haemost. 2007;5(3):542-550.

Hantgan RR, Stahle MC. Entropy drives alpha IIb beta 3 integrin: ligand binding and oligomerization [abstract]. Biophys J. 2007;(Suppl):367a.

Burton RA, Tsurupa G, Hantgan RR, Tjandra N, Medved L. NMR solution structure, stability, and interaction of the recombinant bovine fibrinogen alphaC-domain fragment. Biochemistry. 2007;46(29):8550-8560.

Guthold M, Liu W, Sparks EA, Jawerth LM, Peng L, Falvo M, Superfine R, Hantgan RR, Lord ST. A comparison of the mechanical and structural properties of fibrin fibers with other protein fibers. Cell Biochem Biophys. 2007;49(3):165-181.

Hantgan RR, Stahle MC, Connor JH, Horita DA, Rocco M, McLane MA, Yakovlev S, Medved L. Integrin alphaIIbbeta3:ligand interactions are linked to binding-site remodeling. Protein Sci. 2006;15(8):1893-1906.

Liu W, Jawerth LM, Sparks EA, Falvo MR, Hantgan RR, Superfine R, Lord ST, Guthold M. Fibrin fibers have extraordinary extensibility and elasticity. Science. 2006;313(5787):634.

Levi N, Hantgan RR, Lively MO, Carroll DL, Prasad GL. C60-Fullerenes: detection of intracellular photoluminescence and lack of cytotoxic effects. J Nanobiotechnol. 2006;4():article 14.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Biochemistry

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