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Annette T. Hastie, Ph.D.Wake Forest School of Medicine

Annette T. Hastie, Ph.D.

Associate Professor,


Contact Information

Academic: 336-713-7522 | Department: 336-713-7522

Email: ahastie@wakehealth.edu

Education & Training

  • A.B., Oberlin College , 1968
  • Ph.D., University of Pittsburgh , 1975
  • Fellowship, Johns Hopkins U Sch Hyg & Pub, 1979
  • Fellowship, Medicine, Temple University School of Me, 1984

Memberships

  • Sigma Xi Society
  • Am Soc Of Cell Biology
  • Am Soc Of Microbiology
  • American Thoracic Society
Annette T. Hastie, Ph.D.

Annette T. Hastie, Ph.D.

Associate Professor, Center for Genomics and Personalized Medicine Research
Center for Genomics and Personalized Medicine Research
Pulmonary, Critical Care, Allergy, and Immunologic Medicine

Contact Information

Academic: 336-713-7522 | Department: 336-713-7522

Email: ahastie@wakehealth.edu

Recent Publications

Ortega VE, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Busse WW, Castro M, Chardon D,Erzurum SC, Israel E, Montealegre F, Wezel SE, Peters SP, Meyers DA, Bleecker ER. Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting beta agonist treatment in a multiethnic asthma population: a genetic study. Lancet Respir Med. 2014;2(3):204-213.

Moore WC, Hastie AT, Li X, Li H, Busse WW, Jarjour NN, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis. J Allergy Clin Immunol. 2014;133(6):1557-1563.

Steele C, Dunaway CW, Hastie AT, Ampleford EJ, Bleecker ER, Meyers DA. Defining fungal asthma severity via immune mediator differences in bronchoalveolar lavage fluid and induced sputum from fungal skin test-positive vs. skin test-negative asthmatics [abstract]. Am J Respir Crit Care Med. 2014;189():A2176.

Hawkins G, Robinson MB, Moore WC, Hastie AT, Peters SP, Meyers DA, Bleecker ER, Berry M. Serum soluble IL6 receptor levels are elevated in subjects with COPD and are associated with the IL6R coding variation Asp358Ala [abstract]. Am J Respir Crit Care Med. 2014;189():A4288.

Li X, Moore WC, Hastie AT, Ampleford EJ, Li H, Hawkins GA, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Meyers DA, Bleecker ER. Deciphering functional variants for genes associated with asthma susceptibility using eQTL of bronchial epithelial cells and bronchial alveolar lavage [abstract]. Am J Respir Crit Care Med. 2014;189():A1001.

Hastie AT, Dunaway CW, Moore WC, Foster S, Rector BM, Ampleford E, Bleecker ER, Steele C, Meyers DA. Complex patterns of Th1 inflammatory biomarker associations with cellular constituents of induced sputum in asthma [abstract]. Am J Respir Crit Care Med. 2014;189():A4236.

Romeo J, Hastie AT, Foster S, Moore W, Peters SP, Bleecker ER, Dykewicz MS. LIGHT is associated with increased cellular infiltrate and levels of TH1 cytokines as well as well as [sic] reduced lung function in human asthma [abstract]. J Allergy Clin Immunol. 2013;131(2 Suppl):AB203.

Hastie AT, Moore WC, Li H, Rector BM, Ortega VE, Pascual RM, Peters SP, Meyers DA, Bleecker ER. Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects. J Allergy Clin Immunol. 2013;132(1):72-80.

Li X, Hawkins GA, Ampleford EJ, Moore WC, Li H, Hastie AT, Howard TD, Boushey HA, Busse WW, Calhoun WJ, Castro M, Erzurum SC, Israel E, Lemanske RF Jr, Szefler SJ, Wasserman SI, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients. J Allergy Clin Immunol. 2013;132(2):313-320.

Moore WC, Fitzpatrick AM, Li X, Hastie AT, Li H, Meyers DA, Bleecker ER. Clinical heterogeneity in the severe asthma research program. Ann Am Thorac Soc. 2013;10(Suppl):S118-S124.

Hastie AT, Rector B, Moore WC, Li H, Peters SP, Meyers DA, Bleecker ER. Serum and sputum interleukin-33 (IL-33) levels show no association with serum total IgE, positive skin test number, exhaled nitric oxide, or increasing severity of atopic asthma [abstract]. Am J Respir Crit Care Med. 2013;187():A1008.

Bowers B, Hastie AT, Rector B, Moore WC, Meyers DA, Peters SP, Bleecker ER. Insulin like growth factor binding protein 2 (IGFBP2) is associated with increased sputum cellular infiltrate, increased sputum cytokine levels, and reduced lung function for human subjects with asthma [abstract]. Am J Respir Crit Care Med. 2013;187():A2397.

Li X, Moore WC, Ampleford EJ, Li H, Hawkins G, Hastie AT, Boushey HA, Busse WW, Castro M, Erzurum SC, Israel E, Lamanske RF, Szefler SJ, Wasserman SI, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Phenotypic/genetic characteristics of atopic/non-atopic early/late onset asthma [abstract]. Am J Respir Crit Care Med. 2013;187():A2395.

Hartman JM, Hastie A, Moore WC, Rector B, Peters SP, Bleecker ER, Dykewicz MS. Thioredoxin is positively associated with eosinophils in induced sputum from patients with asthma [abstract]. J Allergy Clin Immunol. 2012;129(2 Suppl):AB209.

Jarjour NN, Erzurum SC, Bleecker ER, Calhoun WJ, Castro M, Comhair SAA, Chung KF, Curran-Everett D, Dweik RA, Fain SB, Fitzpatrick AM, Gaston BM, Israel E, Hastie A, Hoffman EA, Holguin F, Levy BD, Meyers DA, Moore WC, Peters SP,. Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program. Am J Respir Crit Care Med. 2012;185(4):356-362.

Moore WC, Hastie AT, Li H, Li X, Busse WW, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. The addition of sputum inflammatory cell counts to the SARP cluster analysis results in similar clinical asthma phenotypes with biologic heterogeneity [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A3625.

Ortega VE, Hawkins G, Hastie AT, Moore WC, Sadeghnejad A, Busse WW, Erzurum SC, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Effects of rare beta2-adrenergic receptor gene variants and long-acting beta agonists on healthcare utilization and corticosteroid use in two multi-ethnic asthma populations [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A2514.

Hastie AT, Moore WC, Li H, Rector BM, Pascual RM, Peters SP, Meyers DA, Bleecker ER. Blood eosinophils, exhaled nitric oxide, and IGE do not accurately predict sputum eosinophils [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A3926.

Hawkins GA, Robinson MB, Hastie AT, Li X, Li H, Moore WC, Howard TD, Busse WW, Erzurum SC, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. The IL6R variation Asp358 Ala is a potential modifier of lung function in subjects with asthma. J Allergy Clin Immunol. 2012;130(2):510-515.

Ortega VE, Hastie A, Sadeghnejad A, Moore W, Hawkins GA, Peters SP, Busse WW, Calhoun WJ, Meyers DA, Bleecker ER, et al. Rare beta2-adrenergic receptor gene polymorphisms in asthma cases and controls from the Severe Asthma Research Program [abstract]. Am J Respir Crit Care Med. 2011;183(Meeting Abstracts):A1357.

Hawkins GA, Robinson MB, Moore W, Hastie A, Pascual RM, Peters SP, Meyers DA, Bleecker ER. Correlation of serum IL6 with lung function and phenotypic asthma clusters: data from the Severe Asthma Research Program (SARP) [abstract]. Am J Respir Crit Care Med. 2011;183(Meeting Abstracts):A6169.

Hatzis CE, Hastie A, Moore W, Rector B, Sousa A, Knowles R, Peters SP, Meyers DA, Bleecker ER. BAL cell lysate IL1b synthesis and processing correlates with blood eosinophil levels in subjects with asthma [abstract]. Am J Respir Crit Care Med. 2011;183(Meeting Abstracts):A4453.

Hastie AT, Moore WC, Meyers DA, Vestal PL, Li H, Peters SP, Bleecker ER. Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes. J Allergy Clin Immunol. 2010;125(5):1028-1036.

Hastie AT, Albon D, Moore WC, Krings J, Smith RV, Meyers DA, Peters SP, Bleecker ER. Inflammatory protein microarray analysis of sputum from obese subjects with asthma compared with nonobese subjects with asthma [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A6801.

Bhatti SK, Hastie AT, Moore WC, Peters SP, Dykewicz MS, Bleecker ER. Increased numbers of macrophages and neutrophils are associated with decreased interleukin-33 (IL-33) levels in asthmatic sputum [abstract]. J Allergy Clin Immunol. 2010;125(2 Suppl 1):AB109.

Hawkins GA, Robinson MB, Moore WC, Hastie AT, Peters SP, Meyers DA, Bleecker ER. Serum levels of soluble IL6R are genetically regulated and correlate with lung function in asthmatics: Severe Asthma Research Program (SARP) [abstract]. J Allergy Clin Immunol. 2010;125(2 Suppl 1):AB357.

Hastie AT, Moore WC, Meyers DA, Vestal PL, Krings JO, Smith RA, Li H, Peters SP, Bleecker ER. Inflammatory protein analyses of sputum from human subjects with severe or nonsevere asthma [abstract]. Am J Respir Crit Care Med. 2009;179(Online Abstr Issue):A3925.

Breit JS, Hastie AT, Vestal PL, Moore WC, Peters SP, Bleecker ER. Stem cell factor and cKit from asthmatic and normal subjects' epithelial cells and fibroblasts in response to inflammatory mediators [abstract]. Am J Respir Crit Care Med. 2009;179(Online Abstr Issue):A5444.

Laber DM, Hastie AT, Peters SP, Bleecker ER. Quantitative skin testing in asthmatic subjects enrolled in the Severe Asthma Research Program [abstract]. J Allergy Clin Immunol. 2009;123(3):730.

Hite RD, Hastie AT, Seeds MC, Grier BL, Peters SP, Moore WC, Bleecker ER. Surfactant alterations in asthmatics from the Wake Forest Severe Asthma Research Program Center [abstract]. Am J Respir Crit Care Med. 2008;177(Abstr Issue):A100.

Perry CD, Hawkins GA, Hastie AT, Cauthen CG, Diallo A, Li H, Moore WC, Meyers DA, Peters SP, Bleecker ER. Genetic variation in pulmonary and activation-regulated chemokine (PARC/CCL18) in asthma [abstract]. Am J Respir Crit Care Med. 2008;177(Online Abstr Issue):A338.

Cauthen CG, Hastie AT, Wu M, Vestal PL, Moore WC, Krings J, Smith RV, Bleecker ER, Peters SP. Collagen type I fragments associate with cytokines and cell counts in sputum of severe and nonsevere asthmatics [abstract]. Am J Respir Crit Care Med. 2008;177(Online Abstr Issue):A813.

Hastie AT, Vestal PL, Moore WC, Krings J, Smith RV, Peters SP, Bleecker ER. Proteomic microarray analyses of sputum from subjects with asthma compared to subjects with chronic obstructive pulmonary disease (COPD) [abstract]. Am J Respir Crit Care Med. 2008;177(Online Abstr Issue):A960.

Surka AE, Hastie AT, Moore WC, Wu M, Krings J, Smith R, Peters SP, Bleecker ER. Corticosteroid effect on brain derived neurotrophic factor (BDNF) in serum and sputum of asthmatics in vivo, and in asthmatic sputum cells and airway fibroblasts in vitro [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A56.

Hastie AT, Wenzel SE, Chung KF, Busse WW, Bleecker ER. Relationship of sputum cells with pulmonary function, symptoms and health-care utilization as a function of asthma severity [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A153.

McCallister JW, Moore WC, Hastie AT, Vestal PL, Ampleford EJ, Hawkins GA, Wenzel SE, Meyers DA, Bleecker ER. Association of polymorphisms in the tumor necrosis factor-alpha (TNFalpha) gene with levels of TNFalpha and pulmonary function in asthma [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A462.

Surka AE, McCallister JW, Hastie AT, Moore WC, Vestel [sic] PL [Vestal PL], Krings J, Smith R, Peters SP, Bleecker ER. Levels of tumor necrosis factor alpha (TNFa) and brain derived neurotrophic factor (BDNF) correlate in sputum but not in serum [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A681.

McCallister JW, Hastie AT, Moore WC, Vestal PL, Krings JO, Smith RV, Peters SP, Bleecker ER. Lack of correlation between sputum, exhaled breath condensate and serum levels of tumor necrosis factor-alpha (TNFalpha) in asthma [abstract]. Am J Respir Crit Care Med. 2007;175(Abstr Issue):A684.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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