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Annette T. Hastie, Ph.D.Wake Forest School of Medicine

Annette T. Hastie, Ph.D.

Professor,

Contact Information

Academic: 336-713-7522 | Department: 336-713-7522

Email: ahastie@wakehealth.edu

Education & Training

  • A.B., Oberlin College, 1968
  • Ph.D., University of Pittsburgh, 1975
  • Fellowship, Sch Hyg & PH;Johns Hopkins U, 1979
  • Fellowship, Medicine, Temple University School of Me, 1984

Memberships

  • Sigma Xi Society
  • Am Soc Of Cell Biology
  • Am Soc of Microbiology
  • American Thoracic Society
Annette T. Hastie, Ph.D.

Annette T. Hastie, Ph.D.

Professor, Pulmonary, Critical Care, Allergy, and Immunologic Medicine

Research Interests

Asthma; Sputum; Eosinophils; Severity of Illness Index; Neutrophils
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Contact Information

Academic: 336-713-7522 | Department: 336-713-7522

Email: ahastie@wakehealth.edu

Recent Publications

Inflammatory and comorbid features of patients with severe asthma and frequent exacerbations. Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B,.. Am J Respir Crit Care Med. 2017;195(3):302-313.

Effects of age and disease severity on systemic corticosteroid responses in asthma. Phipatanakul W, Mauger DT, Sorkness RL, Gaffin JM, Holguin F, Woodruff PG, Ly NP, Bacharier LB, Bhakta NR, Moore WC, Bleecker ER, Hastie AT, Meyers DA, Castro M, Fahy J, Fitzpatrick A, Gaston BM, Jarjour NN, Levy BD, Peters SP, Teague WG,.. Am J Respir Crit Care Med. 2017;195(11):1439-1448.

Effects of bronchoscopy on lung function in asthmatics. Bellinger C, Bleecker ER, Peters SP, Pascual RM, Krings J, Smith RV, Hasties A [sic] [Hastie A], Moore WC.. J Asthma. 2017;54(8):866-871.

Responsiveness to oral prednisolone in severe asthma is related to the degree of eosinophilic airway inflammation. Sousa AR, Marshall RP, Warnock LC, Bolton S, Hastie A, Symon F, Hargadon B, Marshall H, Richardson M, Brightling CE, Haldar P, Milone R, Chalk P, Williamson R, Panettieri R Jr, Knowles R, Bleecker ER, Wardlaw AJ.. Clin Exp Allergy. 2017;47(7):890-899.

Frequency of exacerbations in patients with chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort. Han MK, Quibrera PM, Carretta EE, Barr RG, Bleecker ER, Bowler RP, Cooper CB, Comellas A, Couper DJ, Curtis JL, Criner G, Dransfield MT, Hansel NN, Hoffman EA, Kanner RE, Krishnan JA, Martinez CH, Pirozzi CB, O'Neal WK, Rennard S, Tashkin DP,.. Lancet Respir Med. 2017;5(8):619-626.

Natural killer cell-mediated inflammation resolution is disabled in severe asthma. Duvall MG, Barnig C, Cernadas M, Ricklefs I, Krishnamoorthy N, Grossman NL, Bhakta NR, Fahy JV, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW,.. Sci Immunol. 2017;2(9):eaam5446.

ALX receptor ligands define a biochemical endotype for severe asthma. Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC,.. JCI Insight. 2017;2(14):e93534.

Baseline features of the Severe Asthma Research Program (SARP III) cohort: differences with age. Teague WG, Phillips BR, Fahy JV, Wenzel SE, Fitzpatrick AM, Moore WC, Hastie AT, Bleecker ER, Meyers DA, Peters SP, Castro M, Coverstone AM, Bacharier LB, Ly NP, Peters MC, Denlinger LC, Ramratnam S, Sorkness RL, Gaston BM, Erzurum SC,.. J Allergy Clin Immunol Pract. 2017;():.

Airway mucin concentration as a marker of chronic bronchitis. Kesimer M, Ford AA, Ceppe A, Radicioni G, Cao R, Davis CW, Doerschuk CM, Alexis NE, Anderson WH, Henderson AG, Barr RG, Bleecker ER, Christenson SA, Cooper CB, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kanner RE, Martinez F, Paine R III,.. N Engl J Med. 2017;377(10):911-922.

Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort [letter]. Martinez CH, Li SX, Hirzel AJ, Stolberg VR, Alexis NE, Barr RG, Bleecker ER, Carretta EE, Christenson SA, Cooper CB, Couper DJ, Doerschuk CM, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kaner RJ, Martinez FJ, Meyers DA, O'Neal WK, Paine R III,.. J Allergy Clin Immunol. 2017;():.

Expression of asthma susceptibility genes in bronchial epithelial cells and bronchial alveolar lavage in the Severe Asthma Research Program (SARP) cohort. Li X, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Milosevic J, Li H, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Bleecker ER, Meyers DA.. J Asthma. 2016;53(8):775-782.

Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts. Peters MC, McGrath KW, Hawkins GA, Hastie AT, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Holguin F, Wenzel SE, Woodruff PG, Bleecker ER, Fahy JV.. Lancet Respir Med. 2016;4(7):574-584.

Blood eosinophils poorly correlate with sputum eosinophils, and have few associations with spirometry, clinical and quantitated computed tomography measures compared to sputum eosinophils in the spiromics cohort [abstract]. Hastie AT, Alexis NE, Doerschuk C, Hansel NN, Christenson S, Putcha N, Ortega VE, Peters SP, Barr RG, Couper DJ, Hoffman EA, Kanner R, Kleerup E, Martinez FJ, Woodruff PG, Han MK, Meyers DA, Curtis JL, Bleecker ER.. Am J Respir Crit Care Med. 2016;193():A6168.

Gene expression reflective of type 2 inflammation in the upper and lower airways of children with asthma in the Severe Asthma Research Program (SARP) [abstract]. Coverstone A, Bacharier LB, Peters M, Fitzpatrick AM, Teague WG, Gaston B, Phipatanakul W, Ly N, Ramratnam S, Fahy JV, Hastie AT, Woodruff PG, Kerr SC, Mauger D, Phillips B, Wenzel SE, Castro M.. Am J Respir Crit Care Med. 2016;193():A1038.

Current smoking increases macrophage numbers and immunoregulatory receptor expression in bronchoalveolar lavage but not sputum in chronic obstructive pulmonary disease: Spiromics Immunophenotyping Sub-Study [abstract]. Brown JP, Freeman CM, Crudgington SW, Stolberg VR, Sonstein J, Alexis NE, Basta PV, Carretta EE, Christenson S, Couper DJ, Doerschuk CM, Hansel NN, Han MK, Hastie AT, Kaner RJ, Martinez FJ, O'Neal WK, Paine R III, Rennard SI, Shimbo D,.. Am J Respir Crit Care Med. 2016;193():A1432.

Active smoking is associated with increased eosinophils in bronchoalveolar lavage but not in sputum or peripheral blood: Spiromics Immunophenotyping Sub-Study [abstract]. Li SX, Hirzel AJ, Freeman CM, Crudgington SW, Stolberg VR, Sonstein J, Alexis NE, Basta PV, Carretta EF, Christenson SA, Couper DJ, Doerschuk CM, Han MK, Hansel NN, Hastie AT, Kaner RJ, Martinez FJ, O'Neal WK, Paine R III, Rennard SI,.. Am J Respir Crit Care Med. 2016;193():A6345.

Role of tumor necrosis factor-related apoptosis inducing ligand and Th1, Th2 and Th17 inflammation in asthma [abstract]. Marks M, Hastie AT, Steele C, Moore WC, Ampleford EJ, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2016;193():A1336.

IL-6 trans-signaling increases expression of airways disease genes in airway smooth muscle. Robinson MB, Deshpande DA, Chou J, Cui W, Smith S, Langefeld C, Hastie AT, Bleecker ER, Hawkins GA.. Am J Physiol Lung Cell Mol Physiol. 2015;309(2):L129-L138.

eQTL of bronchial epithelial cells and bronchial alveolar lavage deciphers GWAS-identified asthma genes. Li X, Hastie AT, Hawkins GA, Moore WC, Ampleford EJ, Milosevic J, Li H, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Meyers DA, Bleecker ER.. Allergy. 2015;70(10):1309-1318.

Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS). Freeman CM, Crudgington S, Stolberg VR, Brown JP, Sonstein J, Alexis NE, Doerschuk CM, Basta PV, Carretta EE, Couper DJ, Hastie AT, Kaner RJ, O'Neal WK, Paine R III, Rennard SI, Shimbo D, Woodruff PG, Zeidler M, Curtis JL.. J Transl Med. 2015;13():19.

Analyses of COPD severity phenotypes and emphysema in spiromics subjects stratified By sputum granulocytes [abstract]. Hastie AT, Doerschuk CM, Alexis NE, Hansel NN, Peters SP, Barr RG, Couper D, Curtis JL, Han MK, Kanner RE, Kleerup EC, Martinez FJ, Putcha N, Rennard SI, Woodruff PG, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2015;191():A2861.

African ancestry is associated with lung function, healthcare utilization, and airways inflammation in African Americans with asthma [abstract]. Ortega VE, Moore WC, Zein J, Hastie AT, Ampleford E, Peters SP, Busse WW, Castro M, Erzurum SC, Israel E, Wenzel SE, Hawkins G, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2015;191():A1061.

Older asthma subjects are less atopic with increased sputum neutrophils [abstract]. Kaur R, Hastie AT, Smith R, Li H, Meyers DA, Bleecker ER, Moore WC.. Am J Respir Crit Care Med. 2015;191():A4324.

Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting beta agonist treatment in a multiethnic asthma population: a genetic study. Ortega VE, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Busse WW, Castro M, Chardon D,Erzurum SC, Israel E, Montealegre F, Wezel SE, Peters SP, Meyers DA, Bleecker ER.. Lancet Respir Med. 2014;2(3):204-213.

Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis. Moore WC, Hastie AT, Li X, Li H, Busse WW, Jarjour NN, Wenzel SE, Peters SP, Meyers DA, Bleecker ER.. J Allergy Clin Immunol. 2014;133(6):1557-1563.

Defining fungal asthma severity via immune mediator differences in bronchoalveolar lavage fluid and induced sputum from fungal skin test-positive vs. skin test-negative asthmatics [abstract]. Steele C, Dunaway CW, Hastie AT, Ampleford EJ, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2014;189():A2176.

Serum soluble IL6 receptor levels are elevated in subjects with COPD and are associated with the IL6R coding variation Asp358Ala [abstract]. Hawkins G, Robinson MB, Moore WC, Hastie AT, Peters SP, Meyers DA, Bleecker ER, Berry M.. Am J Respir Crit Care Med. 2014;189():A4288.

Deciphering functional variants for genes associated with asthma susceptibility using eQTL of bronchial epithelial cells and bronchial alveolar lavage [abstract]. Li X, Moore WC, Hastie AT, Ampleford EJ, Li H, Hawkins GA, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2014;189(Meeting Abstracts):A1001.

Complex patterns of Th1 inflammatory biomarker associations with cellular constituents of induced sputum in asthma [abstract]. Hastie AT, Dunaway CW, Moore WC, Foster S, Rector BM, Ampleford E, Bleecker ER, Steele C, Meyers DA.. Am J Respir Crit Care Med. 2014;189():A4236.

LIGHT is associated with increased cellular infiltrate and levels of TH1 cytokines as well as well as [sic] reduced lung function in human asthma [abstract]. Romeo J, Hastie AT, Foster S, Moore W, Peters SP, Bleecker ER, Dykewicz MS.. J Allergy Clin Immunol. 2013;131(2 Suppl):AB203.

Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects. Hastie AT, Moore WC, Li H, Rector BM, Ortega VE, Pascual RM, Peters SP, Meyers DA, Bleecker ER.. J Allergy Clin Immunol. 2013;132(1):72-80.

Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients. Li X, Hawkins GA, Ampleford EJ, Moore WC, Li H, Hastie AT, Howard TD, Boushey HA, Busse WW, Calhoun WJ, Castro M, Erzurum SC, Israel E, Lemanske RF Jr, Szefler SJ, Wasserman SI, Wenzel SE, Peters SP, Meyers DA, Bleecker ER.. J Allergy Clin Immunol. 2013;132(2):313-320.

Clinical heterogeneity in the severe asthma research program. Moore WC, Fitzpatrick AM, Li X, Hastie AT, Li H, Meyers DA, Bleecker ER.. Ann Am Thorac Soc. 2013;10(Suppl):S118-S124.

Serum and sputum interleukin-33 (IL-33) levels show no association with serum total IgE, positive skin test number, exhaled nitric oxide, or increasing severity of atopic asthma [abstract]. Hastie AT, Rector B, Moore WC, Li H, Peters SP, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2013;187():A1008.

Insulin like growth factor binding protein 2 (IGFBP2) is associated with increased sputum cellular infiltrate, increased sputum cytokine levels, and reduced lung function for human subjects with asthma [abstract]. Bowers B, Hastie AT, Rector B, Moore WC, Meyers DA, Peters SP, Bleecker ER.. Am J Respir Crit Care Med. 2013;187(Meeting Abstracts):A2397.

Phenotypic/genetic characteristics of atopic/non-atopic early/late onset asthma [abstract]. Li X, Moore WC, Ampleford EJ, Li H, Hawkins G, Hastie AT, Boushey HA, Busse WW, Castro M, Erzurum SC, Israel E, Lemanske RF, Szefler SJ, Wasserman SI, Wenzel SE, Peters SP, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2013;187(Meeting Abstracts):A2395.

Thioredoxin is positively associated with eosinophils in induced sputum from patients with asthma [abstract]. Hartman JM, Hastie A, Moore WC, Rector B, Peters SP, Bleecker ER, Dykewicz MS.. J Allergy Clin Immunol. 2012;129(2 Suppl):AB209.

Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program. Jarjour NN, Erzurum SC, Bleecker ER, Calhoun WJ, Castro M, Comhair SAA, Chung KF, Curran-Everett D, Dweik RA, Fain SB, Fitzpatrick AM, Gaston BM, Israel E, Hastie A, Hoffman EA, Holguin F, Levy BD, Meyers DA, Moore WC, Peters SP,.. Am J Respir Crit Care Med. 2012;185(4):356-362.

The addition of sputum inflammatory cell counts to the SARP cluster analysis results in similar clinical asthma phenotypes with biologic heterogeneity [abstract]. Moore WC, Hastie AT, Li H, Li X, Busse WW, Wenzel SE, Peters SP, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A3625.

Effects of rare beta2-adrenergic receptor gene variants and long-acting beta agonists on healthcare utilization and corticosteroid use in two multi-ethnic asthma populations [abstract]. Ortega VE, Hawkins G, Hastie AT, Moore WC, Sadeghnejad A, Busse WW, Erzurum SC, Wenzel SE, Peters SP, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A2514.

Blood eosinophils, exhaled nitric oxide, and IGE do not accurately predict sputum eosinophils [abstract]. Hastie AT, Moore WC, Li H, Rector BM, Pascual RM, Peters SP, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A3926.

The IL6R variation Asp358 Ala is a potential modifier of lung function in subjects with asthma. Hawkins GA, Robinson MB, Hastie AT, Li X, Li H, Moore WC, Howard TD, Busse WW, Erzurum SC, Wenzel SE, Peters SP, Meyers DA, Bleecker ER.. J Allergy Clin Immunol. 2012;130(2):510-515.

Rare beta2-adrenergic receptor gene polymorphisms in asthma cases and controls from the Severe Asthma Research Program [abstract]. Ortega VE, Hastie A, Sadeghnejad A, Moore W, Hawkins GA, Peters SP, Busse WW, Calhoun WJ, Meyers DA, Bleecker ER, et al.. Am J Respir Crit Care Med. 2011;183(Meeting Abstracts):A1357.

Correlation of serum IL6 with lung function and phenotypic asthma clusters: data from the Severe Asthma Research Program (SARP) [abstract]. Hawkins GA, Robinson MB, Moore W, Hastie A, Pascual RM, Peters SP, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2011;183(Meeting Abstracts):A6169.

BAL cell lysate IL1b synthesis and processing correlates with blood eosinophil levels in subjects with asthma [abstract]. Hatzis CE, Hastie A, Moore W, Rector B, Sousa A, Knowles R, Peters SP, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2011;183(Meeting Abstracts):A4453.

Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes. Hastie AT, Moore WC, Meyers DA, Vestal PL, Li H, Peters SP, Bleecker ER.. J Allergy Clin Immunol. 2010;125(5):1028-1036.

Inflammatory protein microarray analysis of sputum from obese subjects with asthma compared with nonobese subjects with asthma [abstract]. Hastie AT, Albon D, Moore WC, Krings J, Smith RV, Meyers DA, Peters SP, Bleecker ER.. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A6801.

Increased numbers of macrophages and neutrophils are associated with decreased interleukin-33 (IL-33) levels in asthmatic sputum [abstract]. Bhatti SK, Hastie AT, Moore WC, Peters SP, Dykewicz MS, Bleecker ER.. J Allergy Clin Immunol. 2010;125(2 Suppl 1):AB109.

Serum levels of soluble IL6R are genetically regulated and correlate with lung function in asthmatics: Severe Asthma Research Program (SARP) [abstract]. Hawkins GA, Robinson MB, Moore WC, Hastie AT, Peters SP, Meyers DA, Bleecker ER.. J Allergy Clin Immunol. 2010;125(2 Suppl 1):AB357.

Inflammatory protein analyses of sputum from human subjects with severe or nonsevere asthma [abstract]. Hastie AT, Moore WC, Meyers DA, Vestal PL, Krings JO, Smith RA, Li H, Peters SP, Bleecker ER.. Am J Respir Crit Care Med. 2009;179(Online Abstr Issue):A3925.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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