Profile

Gregory A. Hawkins, Ph.D.Wake Forest School of Medicine

Education & Training

  • B.A., University of North Carolina-Chapel Hill, 1984
  • Ph.D., University of Maryland-College Park, 1990
Gregory A. Hawkins, Ph.D.

Recent Publications

Traister RS, Uvalle CE, Hawkins GA, Meyers DA, Bleecker ER, Wenzel SE. Phenotypic and genotypic association of epithelial IL1RL1 to human TH2-like asthma. J Allergy Clin Immunol. 2015;135(1):92-99.e10.

Marozkina NV, Wang XQ, Stsiapura V, Fitzpatrick A, Carraro S, Hawkins GA, Bleecker E, Meyers D, Jarjour N, Fain SB, Wenzel S, Busse W, Castro M, Panettieri RA Jr, Moore W, Lewis SJ, Palmer LA, Altes T, de Lange EE, Erzurum S, Teague WG, Gaston B. Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity. Eur Respir J. 2015;45(1):87-97.

Hellwege JN, Palmer ND, Brown MW, Ziegler JT, An SS, Guo X, Chen IY, Taylor K, Hawkins GA, Ng MC, Speliotes EK, Lorenzo C, Norris JM, Rotter JI, Wagenknecht LE, Langefeld CD, Bowden DW. Empirical characteristics of family-based linkage to a complex trait: the ADIPOQ region and adiponectin levels. Hum Genet. 2015;134(2):203-213.

Gomez JL, Crisafi GM, Holm CT, Meyers DA, Hawkins GA, Bleecker ER, Jarjour N, Cohn L, Chupp GL. Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40. J Allergy Clin Immunol. 2015;():.

Robinson MB, Deshpande DA, Chou J, Cui W, Smith S, Langefeld C, Hastie AT, Bleecker ER, Hawkins GA. IL-6 trans-signaling increases expression of airways disease genes in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2015;309(2):L129-L138.

Ortega VE, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Busse WW, Castro M, Chardon D,Erzurum SC, Israel E, Montealegre F, Wezel SE, Peters SP, Meyers DA, Bleecker ER. Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting beta agonist treatment in a multiethnic asthma population: a genetic study. Lancet Respir Med. 2014;2(3):204-213.

Hellwege JN, Palmer ND, Raffield LM, Ng MC, Hawkins GA, Long J, Lorenzo C, Norris JM, Ida Chen YD, Speliotes EK, Rotter JI, Langefeld CD, Wagenknecht LE, Bowden DW. Genome-wide family-based linkage analysis of exome chip variants and cardiometabolic risk. Genet Epidemiol. 2014;38(4):345-352.

Howard TD, Mathias RA, Seeds MC, Herrington DM, Hixson JE, Shimmin LC, Hawkins GA, Sellers M, Ainsworth HC, Sergeant S, Miller LR, Chilton FH. DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver. PLoS One. 2014;9(5):e97510.

Hawkins G, Robinson MB, Bleecker ER, Meyers DA, Peters SP. RNAseq analysis of gene expression in human airway smooth muscle cells: comparison of classical IL6 signaling and IL6 trans-signaling [abstract]. Am J Respir Crit Care Med. 2014;189():A6384.

Hawkins G, Robinson MB, Moore WC, Hastie AT, Peters SP, Meyers DA, Bleecker ER, Berry M. Serum soluble IL6 receptor levels are elevated in subjects with COPD and are associated with the IL6R coding variation Asp358Ala [abstract]. Am J Respir Crit Care Med. 2014;189():A4288.

Li X, Moore WC, Hastie AT, Ampleford EJ, Li H, Hawkins GA, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Meyers DA, Bleecker ER. Deciphering functional variants for genes associated with asthma susceptibility using eQTL of bronchial epithelial cells and bronchial alveolar lavage [abstract]. Am J Respir Crit Care Med. 2014;189(Meeting Abstracts):A1001.

Ortega VE, Moore WC, Hawkins G, Ampleford EJ, Busse WW, Castro M, Erzurum SC, Israel E, Wenzel SE, Peters SP, Bleecker ER, Meyers DA. African ancestry is associated with lower baseline lung function, misclassification of disease severity, and healthcare utilization in African Americans with severe asthma [abstract]. Am J Respir Crit Care Med. 2014;189():A6366.

Cao Q, Wang X, Jia L, Mondal AK, Diallo A, Hawkins GA, Das SK, Parks JS, Yu L, Shi H, Shi H, Xue B. Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation. Endocrinology. 2014;155(12):4925-4938.

Chilton F, Mathias R, Seeds M, Herrington D, Hixson J, Hawkins G, Sergeant S, Miller L, Howard T. DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver [abstract]. FASEB J. 2014;28(1 Suppl):373.8.

Denlinger LC, Manthei DM, Seibold MA, Ahn K, Bleecker E, Boushey HA, Calhoun WJ, Castro M, Chinchili VM, Fahy JV, Hawkins GA, Icitovic N, Israel E, Jarjour NN, King T, Kraft M, Lazarus SC, Lehman E, Martin RJ, Meyers DA,. P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy. Am J Respir Crit Care Med. 2013;187(1):28-33.

Li X, Hawkins GA, Ampleford EJ, Moore WC, Li H, Hastie AT, Howard TD, Boushey HA, Busse WW, Calhoun WJ, Castro M, Erzurum SC, Israel E, Lemanske RF Jr, Szefler SJ, Wasserman SI, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients. J Allergy Clin Immunol. 2013;132(2):313-320.

Liu Y, Ding J, Reynolds LM, Lohman K, Register TC, De La Fuente A, Howard TD, Hawkins GA, Cui W, Morris J, Smith SG, Barr RG, Kaufman JD, Burke GL, Post W, Shea S, McCall CE, Siscovick D, Jacobs DR Jr, Tracy RP,. Methylomics of gene expression in human monocytes. Hum Mol Genet. 2013;22(24):5065-5074.

Cammarata MW, Howard TD, Register TC, Shea SJ, Hawkins GA, Burke GL, Jacobs DR, Hoeschele I, Liu YM, Herrington DM. Association of DNA methylation and gene expression of the P2Y12 receptor: the Multi-Ethnic Study on Atherosclerosis [abstract]. Circulation. 2013;128(22 Suppl):A13189.

Ortega VE, Slager RE, Hawkins G, Moore WC, Busse WW, Erzurum SC, Wenzel SE, Barnes KC, Mathias RA, Bamshad MJ, Nickerson D, Peters SP, Meyers DA, Bleecker ER. Exome sequencing of beta2-adrenergic receptor pathway genes reveals rare variants associated with asthma severity In African Americans [abstract]. Am J Respir Crit Care Med. 2013;187():A2129.

Li X, Moore WC, Ampleford EJ, Li H, Hawkins G, Hastie AT, Boushey HA, Busse WW, Castro M, Erzurum SC, Israel E, Lemanske RF, Szefler SJ, Wasserman SI, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Phenotypic/genetic characteristics of atopic/non-atopic early/late onset asthma [abstract]. Am J Respir Crit Care Med. 2013;187(Meeting Abstracts):A2395.

Ortega VE, Miller SM, Slager RE, Hawkins G, Moore WC, Busse WW, Erzurum SC, Wenzel SE, Barnes KC, Mathias RA, Bamshad MJ, Nickerson D, Peters SP, Bleecker ER, Meyers DA. Whole exome sequencing analysis reveals rare genetic variants associated with response to beta2- adrenergic receptor agonists in African American asthmatics [abstract]. Am J Respir Crit Care Med. 2013;187(Meeting Abstracts):A2122.

Li X, Ampleford EJ, Howard TD, Moore WC, Li H, Busse WW, Castro M, Erzurum SC, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Teague WG, Wenzel SE, Hawkins GA, Bleecker ER, Meyers DA. The C11orf30-LRRC32 region is associated with total serum IgE levels in asthmatic patients [letter]. J Allergy Clin Immunol. 2012;129(2):575-578.

Wu M, Shi L, Cimic A, Romero L, Sui G, Lees CJ, Cline JM, Seals DF, Sirintrapun JS, McCoy TP, Liu W, Kim JW, Hawkins GA, Peehl DM, Xu J, Cramer SD. Suppression of Tak1 promotes prostate tumorigenesis. Cancer Res. 2012;72(11):2833-2843.

Ortega VE, Hawkins G, Moore WC, Sadeghnejad A, Busse WW, Erzurum SC, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Characterization of rare variants in the Adam33 gene in asthma cases from two ethnic groups [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A5609.

Li X, Moore WC, Li H, Ampleford EJ, Busse WW, Erzurum SC, Wenzel SE, Howard TD, Hawkins GA, Meyers DA, Bleecker ER. Phenotype determinants for asthma severity clusters and genetic association for cluster-based asthma severity in Severe Asthma Research Program (SARP) [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A2501.

Hawkins G, Li X, Slager R, Moore WC, Peters SP, Bleecker ER, Meyers DA. Exome sequencing of asthma candidate genes in chromosome 2q11-12 and 2q33 [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A4904.

Ortega VE, Hawkins G, Hastie AT, Moore WC, Sadeghnejad A, Busse WW, Erzurum SC, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Effects of rare beta2-adrenergic receptor gene variants and long-acting beta agonists on healthcare utilization and corticosteroid use in two multi-ethnic asthma populations [abstract]. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A2514.

Hawkins GA, Robinson MB, Hastie AT, Li X, Li H, Moore WC, Howard TD, Busse WW, Erzurum SC, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. The IL6R variation Asp358 Ala is a potential modifier of lung function in subjects with asthma. J Allergy Clin Immunol. 2012;130(2):510-515.

Slager RE, Otulana BA, Hawkins GA, Yen YP, Peters SP, Wenzel SE, Meyers DA, Bleecker ER. IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti-IL-4 receptor alpha antagonist. J Allergy Clin Immunol. 2012;130(2):516-522.

Slager RE, Hawkins GA, Li X, Postma DS, Meyers DA, Bleecker ER. Genetics of asthma susceptibility and severity. Clin Chest Med. 2012;33(3):431-443.

Bostrom MA, Perlegas P, Lu L, Hicks PJ, Hawkins G, Ng MC, Langefeld CD, Freedman BI, Bowden DW. Relevance of the ACTN4 gene in African-Americans with non-diabetic end-stage renal disease. Am J Nephrol. 2012;36(3):252-260.

Li X, Ampleford EJ, Howard TD, Moore WC, Torgerson DG, Li H, Busse WW, Castro M, Erzurum SC, Israel E, Nicolae DL, Ober C, Wenzel SE, Hawkins GA, Bleecker ER, Meyers DA. Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases. J Allergy Clin Immunol. 2012;130(4):861-868.

Duan QL, Gaume BR, Hawkins GA, Himes BE, Bleecker ER, Klanderman B, Irvin CG, Peters SP, Meyers DA, Hanrahan JP, et al. Regulatory haplotypes in ARG1 are associated with altered bronchodilator response. Am J Respir Crit Care Med. 2011;183(4):449-454.

Shepard GC, Lawson HL, Hawkins GA, Owen J. BsaXI/RFLP analysis of initial or selectively reamplified PCR product is unreliable in detecting the V617F mutation in JAK2. Int J Lab Hematol. 2011;33(3):267-271.

Ortega VE, Hastie A, Sadeghnejad A, Moore W, Hawkins GA, Peters SP, Busse WW, Calhoun WJ, Meyers DA, Bleecker ER, et al. Rare beta2-adrenergic receptor gene polymorphisms in asthma cases and controls from the Severe Asthma Research Program [abstract]. Am J Respir Crit Care Med. 2011;183(Meeting Abstracts):A1357.

Li X, Howard TD, Moore WC, Ampleford EJ, Li H, Busse WW, Peters SP, Hawkins GA, Bleecker ER, Meyers DA, et al. Importance of hedgehog interacting protein and other lung function genes in asthma. J Allergy Clin Immunol. 2011;127(6):1457-1465.

Slager RE, Hawkins G, Otulana B, Yen Y, Wenzel SE, Meyers DA, Bleecker ER. Interleukin 4 receptor polymorphisms predict therapeutic pitrakinra treatment response in moderate to severe asthma [abstract]. Am J Respir Crit Care Med. 2011;183():A6178.

Slager RE, Li H, Moore W, Hawkins G, Peters SP, Busse WW, Chung K, Erzurum SC, Meyers DA, Bleecker ER, et al. Predictive model of severe atopic asthma phenotypes using interleukin 4/13 pathway polymorphisms [abstract]. Am J Respir Crit Care Med. 2011;183():A1332.

Gray SB, Langefeld CD, Ziegler JT, Hawkins GA, Wagner JD, Howard TD. Single-nucleotide polymorphisms in the TNF gene are associated with obesity-related phenotypes in vervet monkeys. Obesity (Silver Spring). 2011;19(7):1427-1432.

Howard TD, Ho S-M, Zhang L, Chen J, Cui W, Slager R, Gray S, Hawkins GA, Medvedovic M, Wagner JD. Epigenetic changes with dietary soy in cynomolgus monkeys. PLoS ONE. 2011;6(10):e26791.

Hawkins GA, Robinson MB, Moore W, Hastie A, Pascual RM, Peters SP, Meyers DA, Bleecker ER. Correlation of serum IL6 with lung function and phenotypic asthma clusters: data from the Severe Asthma Research Program (SARP) [abstract]. Am J Respir Crit Care Med. 2011;183(Meeting Abstracts):A6169.

Robinson MB, Deshpande DA, Pascual RM, Panettieri RA, Penn R, Meyers DA, Bleecker ER, Hawkins GA. IL6 signaling in human airway smooth muscle (hasm): distinct signaling effected by the soluble IL6 receptor and functional consequences [abstract]. Am J Respir Crit Care Med. 2011;183():A2074.

Hawkins GA, Moore WC, Robinson MB, Peters SP, Meyers D, Bleecker ER. IL6R polymorphisms predict measures of lung function in caucasian asthmatics: data from the Severe Asthma Research Program (SARP) [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A1298.

Slager RE, Pascual RM, Moore WC, Hawkins GA, Peters SP, Meyers D, Bleecker ER. GATA3 polymorphisms are predictors of steroid use and atopic asthma in the Severe Asthma Research Program [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A1301.

Ortega VE, Hawkins GA, Montealegre F, Chardon D, Sadeghnejad A, Moore WC, Peters SP, Meyers D, Bleecker ER. Rare beta2 adrenergic receptor gene polymorphisms in asthma cases and controls from different ethnic groups [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A1316.

Ortega VE, Liggett SB, Pascual R, Diallo A, Moore WC, Meyers D, Bleecker ER, Hawkins GA. Epigenetics of the beta2-adrenergic receptor gene [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A1306.

Ortega VE, Hawkins GA, Sadeghnejad A, Moore WC, Meyers D, Bleecker ER. Characterization of asthma cases and controls with rare ADAM33 gene polymorphisms in a multi-ethnic population [abstract]. Am J Respir Crit Care Med. 2010;181(1 Meeting Abstracts):A1315.

Cann JA, Kavanagh K, Jorgensen MJ, Mohanan S, Howard TD, Gray SB, Hawkins GA, Fairbanks LA, Wagner JD. Clinicopathologic characterization of naturally occurring diabetes mellitus in vervet monkeys. Vet Pathol. 2010;47(4):713-718.

Panebra A, Wang WC, Malone MM, Pitter DRG, Weiss ST, Hawkins GA, Liggett SB. Common ADRB2 haplotypes derived from 26 polymorphic sites direct beta2-adrenergic receptor expression and regulation phenotypes. PLoS ONE. 2010;5(7):e11819.

Bowden DW, An SS, Palmer ND, Brown WM, Norris JM, Haffner SM, Hawkins GA, Guo X, Wagenknecth LE, Langefeld CD, et al. Molecular basis of a linkage peak: exome sequencing and family-based analysis identify a rare genetic variant in the ADIPOQ gene in the IRAS Family Study. Hum Mol Genet. 2010;19(20):4112-4120.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Quick Reference

Request an Appointment
New Patients

336-716-WAKE
888-716-WAKE

Existing patients may contact the clinic directly.
Find a Doctor Ways to Give
USNWR 2015-2016Magnet Hospital RecognitionConsumer Choice2014 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.