Skip Navigation

Profile

Gregory A. Hawkins, Ph.D.Wake Forest School of Medicine

Gregory A. Hawkins, Ph.D.

Associate Professor,


Contact Information

Academic: 336-713-7511 | Department: 336-716-2011

Email: ghawkins@wakehealth.edu

Education & Training

  • B.A., University of North Carolina-Chapel Hill, 1984
  • Ph.D., University of Maryland-College Park, 1990
Gregory A. Hawkins, Ph.D.

Gregory A. Hawkins, Ph.D.

Associate Professor, Center for Genomics and Personalized Medicine Research
Office of Women in Medicine and Science
Pulmonary, Critical Care, Allergy, and Immunologic Medicine

Research Interests

Asthma; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Anti-Asthmatic Agents; Receptors, Adrenergic, beta-2
More »

Contact Information

Academic: 336-713-7511 | Department: 336-716-2011

Email: ghawkins@wakehealth.edu

Recent Publications

Inflammatory and comorbid features of patients with severe asthma and frequent exacerbations. Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B,.. Am J Respir Crit Care Med. 2017;195(3):302-313.

Genome-wide linkage and association analysis of cardiometabolic phenotypes in Hispanic Americans. Hellwege JN, Palmer ND, Dimitrov L, Keaton JM, Tabb KL, Sajuthi S, Taylor KD, Ng MC, Speliotes EK, Hawkins GA, Long J, Ida Chen YD, Lorenzo C, Norris JM, Rotter JI, Langefeld CD, Wagenknecht LE, Bowden DW.. J Hum Genet. 2017;62(2):175-184.

APOL1 renal-risk variants induce mitochondrial dysfunction. Ma L, Chou JW, Snipes JA, Bharadwaj MS, Craddock AL, Cheng D, Weckerle A, Petrovic S, Hicks PJ, Hemal AK, Hawkins GA, Miller LD, Molina AJ, Langefeld CD, Murea M, Parks JS, Freedman BI.. J Am Soc Nephrol. 2017;28(4):1093-1105.

Effects of age and disease severity on systemic corticosteroid responses in asthma. Phipatanakul W, Mauger DT, Sorkness RL, Gaffin JM, Holguin F, Woodruff PG, Ly NP, Bacharier LB, Bhakta NR, Moore WC, Bleecker ER, Hastie AT, Meyers DA, Castro M, Fahy J, Fitzpatrick A, Gaston BM, Jarjour NN, Levy BD, Peters SP, Teague WG,.. Am J Respir Crit Care Med. 2017;195(11):1439-1448.

Analysis of whole exome sequencing with cardiometabolic traits using family-based linkage and association in the IRAS Family Study. Tabb KL, Hellwege JN, Palmer ND, Dimitrov L, Sajuthi S, Taylor KD, Ng MC, Hawkins GA, Chen YI, Brown WM, McWilliams D, Williams A, Lorenzo C, Norris JM, Long J, Rotter JI, Curran JE, Blangero J, Wagenknecht LE, Langefeld CD, Bowden DW.. Ann Hum Genet. 2017;81(2):49-58.

A null variant in the apolipoprotein L3 gene is associated with non-diabetic nephropathy. Skorecki KL, Lee JH, Langefeld CD, Rosset S, Tzur S, Wasser WG, Shemer R, Hawkins GA, Divers J, Parekh RS, Li M, Sampson MG, Kretzler M, Pollak MR, Shah S, Blackler D, Nichols B, Wilmot M, Alper SL, Freedman BI, Friedman DJ.. Nephrol Dial Transplant. 2017;():.

Safety and tolerability of the first-in-class agent CPI-613 in combination with modified FOLFIRINOX in patients with metastatic pancreatic cancer: a single-centre, open-label, dose-escalation, phase 1 trial. Alistar A, Morris BB, Desnoyer R, Klepin HD, Hosseinzadeh K, Clark C, Cameron A, Leyendecker J, D'Agostino R Jr, Topaloglu U, Boteju LW, Boteju AR, Shorr R, Zachar Z, Bingham PM, Ahmed T, Crane S, Shah R, Migliano JJ, Pardee TS, Miller L,.. Lancet Oncol. 2017;18(6):770-778.

FAM13A, a fatty acid oxidation switch in mitochondria. Friend or foe in chronic obstructive pulmonary disease pathogenesis? [editorial]. Hawkins GA, Mora AL.. Am J Respir Cell Mol Biol. 2017;56(6):689-691.

Adiponectin isoform patterns in ethnic-specific ADIPOQ mutation carriers: the IRAS Family Study. Tabb KL, Gao C, Hicks PJ, Hawkins GA, Rotter JI, Chen YI, Guo X, Norris JM, Lorenzo C, Freedman BI, Bowden DW, Palmer ND.. Obesity (Silver Spring). 2017;25(8):1384-1390.

Mutational landscapes of smoking-related cancers in Caucasians and African Americans: precision oncology perspectives at Wake Forest Baptist Comprehensive Cancer Center. Kytola V, Topaloglu U, Miller LD, Bitting RL, Goodman MM, D Agostino RB Jr, Desnoyers RJ, Albright C, Yacoub G, Qasem SA, DeYoung B, Thorsson V, Shmulevich I, Yang M, Shcherban A, Pagni M, Liu L, Nykter M, Chen K, Hawkins GA, Grant SC,.. Theranostics. 2017;7(11):2914-2923.

Characterization of circulating APOL1 protein complexes in African Americans. Weckerle A, Snipes JA, Cheng D, Gebre AK, Reisz JA, Murea M, Shelness GS, Hawkins GA, Furdui CM, Freedman BI, Parks JS, Ma L.. J Lipid Res. 2016;57(1):120-130.

Tissue-specific and genetic regulation of insulin sensitivity-associated transcripts in African Americans. Sharma NK, Sajuthi SP, Chou JW, Calles-Escandon J, Demons J, Rogers S, Ma L, Palmer ND, R McWilliams D, Beal J, Comeau M, Cherry K, Hawkins GA, Menon L, Kouba E, Davis D, Burris M, Byerly SJ, Easter L, Bowden DW, Freedman BI, Langefeld CD, Das SK.. J Clin Endocrinol Metab. 2016;101(4):1455-1468.

Expression of asthma susceptibility genes in bronchial epithelial cells and bronchial alveolar lavage in the Severe Asthma Research Program (SARP) cohort. Li X, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Milosevic J, Li H, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Bleecker ER, Meyers DA.. J Asthma. 2016;53(8):775-782.

Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts. Peters MC, McGrath KW, Hawkins GA, Hastie AT, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Holguin F, Wenzel SE, Woodruff PG, Bleecker ER, Fahy JV.. Lancet Respir Med. 2016;4(7):574-584.

Common genetic polymorphisms influence blood biomarker measurements in COPD. Sun W, Kechris K, Jacobson S, Drummond MB, Hawkins GA, Yang J, Chen TH, Quibrera PM, Anderson W, Barr RG, Basta PV, Bleecker ER, Beaty T, Casaburi R, Castaldi P, Cho MH, Comellas A, Crapo JD, Criner G, Demeo D, Christenson SA, Couper DJ,.. PLoS Genet. 2016;12(8):e1006011.

Exome sequencing establishes a gelsolin mutation as the cause of inherited bulbar-onset neuropathy. Caress JB, Johnson JO, Abramzon YA, Hawkins GA, Gibbs JR, Sullivan EA, Chahal CS, Traynor BJ.. Muscle Nerve. 2016;():.

Clinical and molecular characterization of the Chi3l1/ykl-40 severe asthma endotypes [abstract]. Gomez JL, Crisafi G, Holm C, Jarjour NN, Hawkins GA, Meyers DA, Bleecker E, Reibman J, Cohn LE, Chupp GL.. Am J Respir Crit Care Med. 2016;193():A4346.

Genetic ancestry is associated with baseline lung function, CT-scan emphysema, and COPD risk in African Americans and Hispanics from spiromics [abstract]. Ortega VE, Hoffman EA, Ampleford EJ, Hawkins GA, Barr RG, Couper DJ, Han MK, Kanner R, Kleerup E, Martinez FJ, Rennard SI, Woodruff PG, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2016;193():A6164.

The bitter taste receptor gene Tas2r42 is a novel asthma severity gene [abstract]. Hawkins GA, Deshpande DA, Ampleford EJ, Li X, Li H, Moore WC, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2016;193():A6681.

Genome-wide association identifies Rs28929474 (glu342lys) in serpina1 associated with post-bronchodilator Fev1/FVC and percent predicted Fev1 in spiromics [abstract]. Li X, Ortega VE, Ampleford EJ, Barr RG, Couper DJ, Han MK, Hoffman EA, Kanner R, Kleerup E, Martinez FJ, Woodruff PG, Hawkins GA, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2016;193():A4431.

Phenotypic/genetic characteristics of COPD, asthma, and asthma-COPD overlap syndrome (acos) in spiromics and sarp [abstract]. Li X, Ortega VE, Nadia H, Christenson S, Moore WC, Li H, Barr RG, Couper DJ, Hoffman EA, Han MK, Kanner R, Kleerup E, Martinez FJ, Hawkins GA, Woodruff PG, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2016;193():A6237.

Phenotypic and genotypic association of epithelial IL1RL1 to human TH2-like asthma. Traister RS, Uvalle CE, Hawkins GA, Meyers DA, Bleecker ER, Wenzel SE.. J Allergy Clin Immunol. 2015;135(1):92-99.e10.

Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity. Marozkina NV, Wang XQ, Stsiapura V, Fitzpatrick A, Carraro S, Hawkins GA, Bleecker E, Meyers D, Jarjour N, Fain SB, Wenzel S, Busse W, Castro M, Panettieri RA Jr, Moore W, Lewis SJ, Palmer LA, Altes T, de Lange EE, Erzurum S, Teague WG, Gaston B.. Eur Respir J. 2015;45(1):87-97.

Empirical characteristics of family-based linkage to a complex trait: the ADIPOQ region and adiponectin levels. Hellwege JN, Palmer ND, Brown MW, Ziegler JT, An SS, Guo X, Chen IY, Taylor K, Hawkins GA, Ng MC, Speliotes EK, Lorenzo C, Norris JM, Rotter JI, Wagenknecht LE, Langefeld CD, Bowden DW.. Hum Genet. 2015;134(2):203-213.

Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40. Gomez JL, Crisafi GM, Holm CT, Meyers DA, Hawkins GA, Bleecker ER, Jarjour N, Cohn L, Chupp GL.. J Allergy Clin Immunol. 2015;136(1):51-58.e10.

IL-6 trans-signaling increases expression of airways disease genes in airway smooth muscle. Robinson MB, Deshpande DA, Chou J, Cui W, Smith S, Langefeld C, Hastie AT, Bleecker ER, Hawkins GA.. Am J Physiol Lung Cell Mol Physiol. 2015;309(2):L129-L138.

eQTL of bronchial epithelial cells and bronchial alveolar lavage deciphers GWAS-identified asthma genes. Li X, Hastie AT, Hawkins GA, Moore WC, Ampleford EJ, Milosevic J, Li H, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Meyers DA, Bleecker ER.. Allergy. 2015;70(10):1309-1318.

Re-sequencing of the APOL1-APOL4 and MYH9 gene regions in African Americans does not identify additional risks for CKD progression. Hawkins GA, Friedman DJ, Lu L, McWilliams DR, Chou JW, Sajuthi S, Divers J, Parekh RS, Li M, Genovese G, Pollack MR, Hicks PJ, Bowden DW, Ma L, Freedman BI, Langefeld CD.. Am J Nephrol. 2015;42(2):99-106.

Clinical implications of RAR-beta methylation in cancer tissue and peripheral blood leukocytes of patients with lung cancer [abstract]. Ansley KC, Dotson T, Hawkins G, Petty WJ.. Int J Mol Med. 2015;36(Suppl 1):S103.

Characterization of circulating APOL1 complexes and their kidney distribution in African Americans [abstract]. Ma L, Weckerle A, Snipes JA, Cheng D, Gebre AK, Murea M, Hawkins GA, Parks JS, Freedman BI.. J Am Soc Nephrol. 2015;26(Abstract Suppl):708A.

The Rs12141494 polymorphism in Chi3l1 is associated with asthma severity and airway expression of Ykl-40 [abstract]. Gomez JL, Crisafi G, Holm C, Meyers DA, Hawkins GA, Bleecker ER, Jarjour NN, Cohn LE, Chupp GL.. Am J Respir Crit Care Med. 2015;191():A1057.

Blood biomarker quantitative trail loci in chronic obstructive pulmonary disease [abstract]. Jacobson S, Kechris K, Sun W, Yang J, Chen TH, Barr RG, Basta P, Bleecker ER, Couper D, Curtis JL, Doerschuk CM, Drummond MB, Han MK, Hansel NN, Hawkins G, Hoffman EA, Kanner R, Kleerup EC, Martinez FJ, Meyers DA, O'Neal WK, Peters SP,.. Am J Respir Crit Care Med. 2015;191():A3627.

African ancestry is associated with disease misclassification, airflow obstruction, and CT scan emphysema in African Americans from spiromics [abstract]. Ortega VE, Ampleford EJ, Hawkins G, Barr RG, Couper D, Han MK, Hoffman EA, Kanner RE, Kleerup EC, Martinez FJ, Rennard SI, Woodruff PG, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2015;191():A2297.

African ancestry is associated with lung function, healthcare utilization, and airways inflammation in African Americans with asthma [abstract]. Ortega VE, Moore WC, Zein J, Hastie AT, Ampleford E, Peters SP, Busse WW, Castro M, Erzurum SC, Israel E, Wenzel SE, Hawkins G, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2015;191():A1061.

Rare serpina1 variants are associated with lung function and health care utilization in a multi-ethnic population from the Severe Asthma Research Program (sarp) [abstract]. Pasha S, Orgega VE, Ampleford EJ, Bamshad MJ, Barnes KC, Busse WW, Castro M, Erzurum SC, Israel E, Mathias RA, Nickerson D, Wenzel SE, Hawkins G, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2015;191():A6057.

Evaluation of genetic variants in Il6 and Il6r in the Nhlbi subpopulations and intermediate outcome measures in COPD study (spiromics) [abstract]. Hawkins GA, Ampleford EJ, Ortega VE, Li X, Peters SP, Barr RG, Couper D, Han MK, Kanner R, Kleerup EC, Martinez FJ, Rennard SI, Woodruff PG, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2015;191():A4693.

Mechanisms for the genetic association between Il1rl1 and human asthma [abstract]. Traister RS, Hawkins G, Meyers DA, Bleecker ER, Zhao Y, Wenzel SE.. Am J Respir Crit Care Med. 2015;191():A3629.

Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting beta agonist treatment in a multiethnic asthma population: a genetic study. Ortega VE, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Busse WW, Castro M, Chardon D,Erzurum SC, Israel E, Montealegre F, Wezel SE, Peters SP, Meyers DA, Bleecker ER.. Lancet Respir Med. 2014;2(3):204-213.

Genome-wide family-based linkage analysis of exome chip variants and cardiometabolic risk. Hellwege JN, Palmer ND, Raffield LM, Ng MC, Hawkins GA, Long J, Lorenzo C, Norris JM, Ida Chen YD, Speliotes EK, Rotter JI, Langefeld CD, Wagenknecht LE, Bowden DW.. Genet Epidemiol. 2014;38(4):345-352.

DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver. Howard TD, Mathias RA, Seeds MC, Herrington DM, Hixson JE, Shimmin LC, Hawkins GA, Sellers M, Ainsworth HC, Sergeant S, Miller LR, Chilton FH.. PLoS One. 2014;9(5):e97510.

RNAseq analysis of gene expression in human airway smooth muscle cells: comparison of classical IL6 signaling and IL6 trans-signaling [abstract]. Hawkins G, Robinson MB, Bleecker ER, Meyers DA, Peters SP.. Am J Respir Crit Care Med. 2014;189():A6384.

Serum soluble IL6 receptor levels are elevated in subjects with COPD and are associated with the IL6R coding variation Asp358Ala [abstract]. Hawkins G, Robinson MB, Moore WC, Hastie AT, Peters SP, Meyers DA, Bleecker ER, Berry M.. Am J Respir Crit Care Med. 2014;189():A4288.

Deciphering functional variants for genes associated with asthma susceptibility using eQTL of bronchial epithelial cells and bronchial alveolar lavage [abstract]. Li X, Moore WC, Hastie AT, Ampleford EJ, Li H, Hawkins GA, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2014;189(Meeting Abstracts):A1001.

African ancestry is associated with lower baseline lung function, misclassification of disease severity, and healthcare utilization in African Americans with severe asthma [abstract]. Ortega VE, Moore WC, Hawkins G, Ampleford EJ, Busse WW, Castro M, Erzurum SC, Israel E, Wenzel SE, Peters SP, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2014;189():A6366.

Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation. Cao Q, Wang X, Jia L, Mondal AK, Diallo A, Hawkins GA, Das SK, Parks JS, Yu L, Shi H, Shi H, Xue B.. Endocrinology. 2014;155(12):4925-4938.

DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver [abstract]. Chilton F, Mathias R, Seeds M, Herrington D, Hixson J, Hawkins G, Sergeant S, Miller L, Howard T.. FASEB J. 2014;28(1 Suppl):373.8.

P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy. Denlinger LC, Manthei DM, Seibold MA, Ahn K, Bleecker E, Boushey HA, Calhoun WJ, Castro M, Chinchili VM, Fahy JV, Hawkins GA, Icitovic N, Israel E, Jarjour NN, King T, Kraft M, Lazarus SC, Lehman E, Martin RJ, Meyers DA,.. Am J Respir Crit Care Med. 2013;187(1):28-33.

Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients. Li X, Hawkins GA, Ampleford EJ, Moore WC, Li H, Hastie AT, Howard TD, Boushey HA, Busse WW, Calhoun WJ, Castro M, Erzurum SC, Israel E, Lemanske RF Jr, Szefler SJ, Wasserman SI, Wenzel SE, Peters SP, Meyers DA, Bleecker ER.. J Allergy Clin Immunol. 2013;132(2):313-320.

Methylomics of gene expression in human monocytes. Liu Y, Ding J, Reynolds LM, Lohman K, Register TC, De La Fuente A, Howard TD, Hawkins GA, Cui W, Morris J, Smith SG, Barr RG, Kaufman JD, Burke GL, Post W, Shea S, McCall CE, Siscovick D, Jacobs DR Jr, Tracy RP,.. Hum Mol Genet. 2013;22(24):5065-5074.

Association of DNA methylation and gene expression of the P2Y12 receptor: the Multi-Ethnic Study on Atherosclerosis [abstract]. Cammarata MW, Howard TD, Register TC, Shea SJ, Hawkins GA, Burke GL, Jacobs DR, Hoeschele I, Liu YM, Herrington DM.. Circulation. 2013;128(22 Suppl):A13189.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Quick Reference

Request an Appointment
New Patients

336-716-WAKE
888-716-WAKE

Existing patients may contact the clinic directly.
Find a Doctor Ways to Give
Six Wake Forest Baptist Specialties Earn U.S. News RankingsComprehensive Cancer Centers National Designation is Renewed2017-2018 Best DoctorsMagnet Hospital RecognitionJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.

© Wake Forest Baptist Medical Center, Medical Center Boulevard, Winston-Salem, NC 27157. All Rights Reserved.