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Gregory A. Hawkins, Ph.D.Wake Forest School of Medicine

Gregory A. Hawkins, Ph.D.

Associate Professor,


Contact Information

Academic: 336-713-7511 | Department: 336-716-2011

Email: ghawkins@wakehealth.edu

Education & Training

  • B.A., University of North Carolina-Chapel Hill, 1984
  • Ph.D., University of Maryland-College Park, 1990
Gregory A. Hawkins, Ph.D.

Gregory A. Hawkins, Ph.D.

Associate Professor, Center for Genomics and Personalized Medicine Research
Office of Women in Medicine and Science
Pulmonary, Critical Care, Allergy, and Immunologic Medicine

Research Interests

Asthma; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Anti-Asthmatic Agents; Receptors, Adrenergic, beta-2
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Contact Information

Academic: 336-713-7511 | Department: 336-716-2011

Email: ghawkins@wakehealth.edu

Recent Publications

Characterization of circulating APOL1 protein complexes in African Americans. Weckerle A, Snipes JA, Cheng D, Gebre AK, Reisz JA, Murea M, Shelness GS, Hawkins GA, Furdui CM, Freedman BI, Parks JS, Ma L.. J Lipid Res. 2016;57(1):120-130.

Tissue-specific and genetic regulation of insulin sensitivity-associated transcripts in African Americans. Sharma NK, Sajuthi SP, Chou JW, Calles-Escandon J, Demons J, Rogers S, Ma L, Palmer ND, R McWilliams D, Beal J, Comeau M, Cherry K, Hawkins GA, Menon L, Kouba E, Davis D, Burris M, Byerly SJ, Easter L, Bowden DW, Freedman BI, Langefeld CD, Das SK.. J Clin Endocrinol Metab. 2016;101(4):1455-1468.

Expression of asthma susceptibility genes in bronchial epithelial cells and bronchial alveolar lavage in the Severe Asthma Research Program (SARP) cohort. Li X, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Milosevic J, Li H, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Bleecker ER, Meyers DA.. J Asthma. 2016;53(8):775-782.

Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts. Peters MC, McGrath KW, Hawkins GA, Hastie AT, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Holguin F, Wenzel SE, Woodruff PG, Bleecker ER, Fahy JV.. Lancet Respir Med. 2016;4(7):574-584.

Inflammatory and co-morbid features of patients with severe asthma and frequent exacerbations. Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B,.. Am J Respir Crit Care Med. 2016;():.

Genome-wide linkage and association analysis of cardiometabolic phenotypes in Hispanic Americans. Hellwege JN, Palmer ND, Dimitrov L, Keaton JM, Tabb KL, Sajuthi S, Taylor KD, Ng MC, Speliotes EK, Hawkins GA, Long J, Ida Chen YD, Lorenzo C, Norris JM, Rotter JI, Langefeld CD, Wagenknecht LE, Bowden DW.. J Hum Genet. 2016;():.

Common genetic polymorphisms influence blood biomarker measurements in COPD. Sun W, Kechris K, Jacobson S, Drummond MB, Hawkins GA, Yang J, Chen TH, Quibrera PM, Anderson W, Barr RG, Basta PV, Bleecker ER, Beaty T, Casaburi R, Castaldi P, Cho MH, Comellas A, Crapo JD, Criner G, Demeo D, Christenson SA, Couper DJ,.. PLoS Genet. 2016;12(8):e1006011.

Phenotypic and genotypic association of epithelial IL1RL1 to human TH2-like asthma. Traister RS, Uvalle CE, Hawkins GA, Meyers DA, Bleecker ER, Wenzel SE.. J Allergy Clin Immunol. 2015;135(1):92-99.e10.

Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity. Marozkina NV, Wang XQ, Stsiapura V, Fitzpatrick A, Carraro S, Hawkins GA, Bleecker E, Meyers D, Jarjour N, Fain SB, Wenzel S, Busse W, Castro M, Panettieri RA Jr, Moore W, Lewis SJ, Palmer LA, Altes T, de Lange EE, Erzurum S, Teague WG, Gaston B.. Eur Respir J. 2015;45(1):87-97.

Empirical characteristics of family-based linkage to a complex trait: the ADIPOQ region and adiponectin levels. Hellwege JN, Palmer ND, Brown MW, Ziegler JT, An SS, Guo X, Chen IY, Taylor K, Hawkins GA, Ng MC, Speliotes EK, Lorenzo C, Norris JM, Rotter JI, Wagenknecht LE, Langefeld CD, Bowden DW.. Hum Genet. 2015;134(2):203-213.

Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40. Gomez JL, Crisafi GM, Holm CT, Meyers DA, Hawkins GA, Bleecker ER, Jarjour N, Cohn L, Chupp GL.. J Allergy Clin Immunol. 2015;136(1):51-58.e10.

IL-6 trans-signaling increases expression of airways disease genes in airway smooth muscle. Robinson MB, Deshpande DA, Chou J, Cui W, Smith S, Langefeld C, Hastie AT, Bleecker ER, Hawkins GA.. Am J Physiol Lung Cell Mol Physiol. 2015;309(2):L129-L138.

eQTL of bronchial epithelial cells and bronchial alveolar lavage deciphers GWAS-identified asthma genes. Li X, Hastie AT, Hawkins GA, Moore WC, Ampleford EJ, Milosevic J, Li H, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Meyers DA, Bleecker ER.. Allergy. 2015;70(10):1309-1318.

Re-sequencing of the APOL1-APOL4 and MYH9 gene regions in African Americans does not identify additional risks for CKD progression. Hawkins GA, Friedman DJ, Lu L, McWilliams DR, Chou JW, Sajuthi S, Divers J, Parekh RS, Li M, Genovese G, Pollack MR, Hicks PJ, Bowden DW, Ma L, Freedman BI, Langefeld CD.. Am J Nephrol. 2015;42(2):99-106.

Clinical implications of RAR-beta methylation in cancer tissue and peripheral blood leukocytes of patients with lung cancer [abstract]. Ansley KC, Dotson T, Hawkins G, Petty WJ.. Int J Mol Med. 2015;36(Suppl 1):S103.

Characterization of circulating APOL1 complexes and their kidney distribution in African Americans [abstract]. Ma L, Weckerle A, Snipes JA, Cheng D, Gebre AK, Murea M, Hawkins GA, Parks JS, Freedman BI.. J Am Soc Nephrol. 2015;26(Abstract Suppl):708A.

The Rs12141494 polymorphism in Chi3l1 is associated with asthma severity and airway expression of Ykl-40 [abstract]. Gomez JL, Crisafi G, Holm C, Meyers DA, Hawkins GA, Bleecker ER, Jarjour NN, Cohn LE, Chupp GL.. Am J Respir Crit Care Med. 2015;191():A1057.

Blood biomarker quantitative trail loci in chronic obstructive pulmonary disease [abstract]. Jacobson S, Kechris K, Sun W, Yang J, Chen TH, Barr RG, Basta P, Bleecker ER, Couper D, Curtis JL, Doerschuk CM, Drummond MB, Han MK, Hansel NN, Hawkins G, Hoffman EA, Kanner R, Kleerup EC, Martinez FJ, Meyers DA, O'Neal WK, Peters SP,.. Am J Respir Crit Care Med. 2015;191():A3627.

African ancestry is associated with disease misclassification, airflow obstruction, and CT scan emphysema in African Americans from spiromics [abstract]. Ortega VE, Ampleford EJ, Hawkins G, Barr RG, Couper D, Han MK, Hoffman EA, Kanner RE, Kleerup EC, Martinez FJ, Rennard SI, Woodruff PG, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2015;191():A2297.

African ancestry is associated with lung function, healthcare utilization, and airways inflammation in African Americans with asthma [abstract]. Ortega VE, Moore WC, Zein J, Hastie AT, Ampleford E, Peters SP, Busse WW, Castro M, Erzurum SC, Israel E, Wenzel SE, Hawkins G, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2015;191():A1061.

Rare serpina1 variants are associated with lung function and health care utilization in a multi-ethnic population from the Severe Asthma Research Program (sarp) [abstract]. Pasha S, Orgega VE, Ampleford EJ, Bamshad MJ, Barnes KC, Busse WW, Castro M, Erzurum SC, Israel E, Mathias RA, Nickerson D, Wenzel SE, Hawkins G, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2015;191():A6057.

Evaluation of genetic variants in Il6 and Il6r in the Nhlbi subpopulations and intermediate outcome measures in COPD study (spiromics) [abstract]. Hawkins GA, Ampleford EJ, Ortega VE, Li X, Peters SP, Barr RG, Couper D, Han MK, Kanner R, Kleerup EC, Martinez FJ, Rennard SI, Woodruff PG, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2015;191():A4693.

Mechanisms for the genetic association between Il1rl1 and human asthma [abstract]. Traister RS, Hawkins G, Meyers DA, Bleecker ER, Zhao Y, Wenzel SE.. Am J Respir Crit Care Med. 2015;191():A3629.

Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting beta agonist treatment in a multiethnic asthma population: a genetic study. Ortega VE, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Busse WW, Castro M, Chardon D,Erzurum SC, Israel E, Montealegre F, Wezel SE, Peters SP, Meyers DA, Bleecker ER.. Lancet Respir Med. 2014;2(3):204-213.

Genome-wide family-based linkage analysis of exome chip variants and cardiometabolic risk. Hellwege JN, Palmer ND, Raffield LM, Ng MC, Hawkins GA, Long J, Lorenzo C, Norris JM, Ida Chen YD, Speliotes EK, Rotter JI, Langefeld CD, Wagenknecht LE, Bowden DW.. Genet Epidemiol. 2014;38(4):345-352.

DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver. Howard TD, Mathias RA, Seeds MC, Herrington DM, Hixson JE, Shimmin LC, Hawkins GA, Sellers M, Ainsworth HC, Sergeant S, Miller LR, Chilton FH.. PLoS One. 2014;9(5):e97510.

RNAseq analysis of gene expression in human airway smooth muscle cells: comparison of classical IL6 signaling and IL6 trans-signaling [abstract]. Hawkins G, Robinson MB, Bleecker ER, Meyers DA, Peters SP.. Am J Respir Crit Care Med. 2014;189():A6384.

Serum soluble IL6 receptor levels are elevated in subjects with COPD and are associated with the IL6R coding variation Asp358Ala [abstract]. Hawkins G, Robinson MB, Moore WC, Hastie AT, Peters SP, Meyers DA, Bleecker ER, Berry M.. Am J Respir Crit Care Med. 2014;189():A4288.

Deciphering functional variants for genes associated with asthma susceptibility using eQTL of bronchial epithelial cells and bronchial alveolar lavage [abstract]. Li X, Moore WC, Hastie AT, Ampleford EJ, Li H, Hawkins GA, Busse WW, Erzurum SC, Kaminski N, Wenzel SE, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2014;189(Meeting Abstracts):A1001.

African ancestry is associated with lower baseline lung function, misclassification of disease severity, and healthcare utilization in African Americans with severe asthma [abstract]. Ortega VE, Moore WC, Hawkins G, Ampleford EJ, Busse WW, Castro M, Erzurum SC, Israel E, Wenzel SE, Peters SP, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2014;189():A6366.

Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation. Cao Q, Wang X, Jia L, Mondal AK, Diallo A, Hawkins GA, Das SK, Parks JS, Yu L, Shi H, Shi H, Xue B.. Endocrinology. 2014;155(12):4925-4938.

DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver [abstract]. Chilton F, Mathias R, Seeds M, Herrington D, Hixson J, Hawkins G, Sergeant S, Miller L, Howard T.. FASEB J. 2014;28(1 Suppl):373.8.

P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy. Denlinger LC, Manthei DM, Seibold MA, Ahn K, Bleecker E, Boushey HA, Calhoun WJ, Castro M, Chinchili VM, Fahy JV, Hawkins GA, Icitovic N, Israel E, Jarjour NN, King T, Kraft M, Lazarus SC, Lehman E, Martin RJ, Meyers DA,.. Am J Respir Crit Care Med. 2013;187(1):28-33.

Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients. Li X, Hawkins GA, Ampleford EJ, Moore WC, Li H, Hastie AT, Howard TD, Boushey HA, Busse WW, Calhoun WJ, Castro M, Erzurum SC, Israel E, Lemanske RF Jr, Szefler SJ, Wasserman SI, Wenzel SE, Peters SP, Meyers DA, Bleecker ER.. J Allergy Clin Immunol. 2013;132(2):313-320.

Methylomics of gene expression in human monocytes. Liu Y, Ding J, Reynolds LM, Lohman K, Register TC, De La Fuente A, Howard TD, Hawkins GA, Cui W, Morris J, Smith SG, Barr RG, Kaufman JD, Burke GL, Post W, Shea S, McCall CE, Siscovick D, Jacobs DR Jr, Tracy RP,.. Hum Mol Genet. 2013;22(24):5065-5074.

Association of DNA methylation and gene expression of the P2Y12 receptor: the Multi-Ethnic Study on Atherosclerosis [abstract]. Cammarata MW, Howard TD, Register TC, Shea SJ, Hawkins GA, Burke GL, Jacobs DR, Hoeschele I, Liu YM, Herrington DM.. Circulation. 2013;128(22 Suppl):A13189.

Exome sequencing of beta2-adrenergic receptor pathway genes reveals rare variants associated with asthma severity In African Americans [abstract]. Ortega VE, Slager RE, Hawkins G, Moore WC, Busse WW, Erzurum SC, Wenzel SE, Barnes KC, Mathias RA, Bamshad MJ, Nickerson D, Peters SP, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2013;187():A2129.

Phenotypic/genetic characteristics of atopic/non-atopic early/late onset asthma [abstract]. Li X, Moore WC, Ampleford EJ, Li H, Hawkins G, Hastie AT, Boushey HA, Busse WW, Castro M, Erzurum SC, Israel E, Lemanske RF, Szefler SJ, Wasserman SI, Wenzel SE, Peters SP, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2013;187(Meeting Abstracts):A2395.

Whole exome sequencing analysis reveals rare genetic variants associated with response to beta2- adrenergic receptor agonists in African American asthmatics [abstract]. Ortega VE, Miller SM, Slager RE, Hawkins G, Moore WC, Busse WW, Erzurum SC, Wenzel SE, Barnes KC, Mathias RA, Bamshad MJ, Nickerson D, Peters SP, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2013;187(Meeting Abstracts):A2122.

The C11orf30-LRRC32 region is associated with total serum IgE levels in asthmatic patients [letter]. Li X, Ampleford EJ, Howard TD, Moore WC, Li H, Busse WW, Castro M, Erzurum SC, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Teague WG, Wenzel SE, Hawkins GA, Bleecker ER, Meyers DA.. J Allergy Clin Immunol. 2012;129(2):575-578.

Suppression of Tak1 promotes prostate tumorigenesis. Wu M, Shi L, Cimic A, Romero L, Sui G, Lees CJ, Cline JM, Seals DF, Sirintrapun JS, McCoy TP, Liu W, Kim JW, Hawkins GA, Peehl DM, Xu J, Cramer SD.. Cancer Res. 2012;72(11):2833-2843.

Characterization of rare variants in the Adam33 gene in asthma cases from two ethnic groups [abstract]. Ortega VE, Hawkins G, Moore WC, Sadeghnejad A, Busse WW, Erzurum SC, Wenzel SE, Peters SP, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A5609.

Phenotype determinants for asthma severity clusters and genetic association for cluster-based asthma severity in Severe Asthma Research Program (SARP) [abstract]. Li X, Moore WC, Li H, Ampleford EJ, Busse WW, Erzurum SC, Wenzel SE, Howard TD, Hawkins GA, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A2501.

Exome sequencing of asthma candidate genes in chromosome 2q11-12 and 2q33 [abstract]. Hawkins G, Li X, Slager R, Moore WC, Peters SP, Bleecker ER, Meyers DA.. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A4904.

Effects of rare beta2-adrenergic receptor gene variants and long-acting beta agonists on healthcare utilization and corticosteroid use in two multi-ethnic asthma populations [abstract]. Ortega VE, Hawkins G, Hastie AT, Moore WC, Sadeghnejad A, Busse WW, Erzurum SC, Wenzel SE, Peters SP, Meyers DA, Bleecker ER.. Am J Respir Crit Care Med. 2012;185(Meeting Abstracts):A2514.

The IL6R variation Asp358 Ala is a potential modifier of lung function in subjects with asthma. Hawkins GA, Robinson MB, Hastie AT, Li X, Li H, Moore WC, Howard TD, Busse WW, Erzurum SC, Wenzel SE, Peters SP, Meyers DA, Bleecker ER.. J Allergy Clin Immunol. 2012;130(2):510-515.

IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti-IL-4 receptor alpha antagonist. Slager RE, Otulana BA, Hawkins GA, Yen YP, Peters SP, Wenzel SE, Meyers DA, Bleecker ER.. J Allergy Clin Immunol. 2012;130(2):516-522.

Genetics of asthma susceptibility and severity. Slager RE, Hawkins GA, Li X, Postma DS, Meyers DA, Bleecker ER.. Clin Chest Med. 2012;33(3):431-443.

Relevance of the ACTN4 gene in African-Americans with non-diabetic end-stage renal disease. Bostrom MA, Perlegas P, Lu L, Hicks PJ, Hawkins G, Ng MC, Langefeld CD, Freedman BI, Bowden DW.. Am J Nephrol. 2012;36(3):252-260.

Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases. Li X, Ampleford EJ, Howard TD, Moore WC, Torgerson DG, Li H, Busse WW, Castro M, Erzurum SC, Israel E, Nicolae DL, Ober C, Wenzel SE, Hawkins GA, Bleecker ER, Meyers DA.. J Allergy Clin Immunol. 2012;130(4):861-868.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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