Kenichiro Hayashida, D.V.M., Ph.D.Wake Forest School of Medicine

Kenichiro Hayashida, D.V.M., Ph.D.

Assistant Professor,

Contact Information

Academic: 336-716-3452 | Department: 336-716-3452


Additional Languages


Education & Training

  • D.V.M., Hokkaido University School of Veterinary Medicine, 1996
  • Ph.D., Yamaguchi Univ Graduate Sch of Veterinary Medicine, 2004
  • Fellowship, Pain Medicine, WFU School of Medicine, 2008


  • Society for Neuroscience
  • Am Pain Society
  • Int'l Assn For The Study Of Pa
Kenichiro Hayashida, D.V.M., Ph.D.

Kenichiro Hayashida, D.V.M., Ph.D.

Assistant Professor, Anesthesiology

Research Interests

neurosciences/behavior, pain

Contact Information

Academic: 336-716-3452 | Department: 336-716-3452


Recent Publications

Boada MD, Gutierrez S, Aschenbrenner CA, Houle TT, Hayashida KI, Ririe DG, Eisenach JC. Nerve injury induces a new profile of tactile and mechanical nociceptor input from undamaged peripheral afferents. J Neurophysiol. 2015;113(1):100-109.

Peters CM, Hayashida KI, Suto T, Houle TT, Aschenbrenner CA, Martin TJ, Eisenach JC. Individual differences in acute pain-induced endogenous analgesia predict time to resolution of postoperative pain in the rat. Anesthesiology. 2015;122(4):895-907.

Ding H, Hayashida K, Suto T, Sukhtankar DD, Kimura M, Mendenhall V, Ko MC. Supraspinal actions of nociceptin/orphanin FQ, morphine and substance P in regulating pain and itch in non-human primates. Br J Pharmacol. 2015;172(13):3302-3312.

Hayashida K, Kimura M, Peters C, Eisenach J. Down-regulation of astroglial glutamate transporters in the locus coeruleus contributes to impairment of endogenous analgesia in rats after peripheral nerve injury [abstract]. J Pain. 2015;16(4 Suppl 1):S50.

Danilo Boada M, Martin TJ, Peters CM, Hayashida K, Harris MH, Houle TT, Boyden ES, Eisenach JC, Ririe DG. Fast-conducting mechanoreceptors contribute to withdrawal behavior in normal and nerve injured rats. Pain. 2014;155(12):2646-2655.

Gutierrez S, Hayashida K, Eisenach JC. The puerperium alters spinal cord plasticity following peripheral nerve injury. Neuroscience. 2013;228():301-308.

Kimura M, Hayashida K, Eisenach JC, Saito S, Obata H. Relief of hypersensitivity after nerve injury from systemic donepezil involves spinal cholinergic and gamma-aminobutyric acid mechanisms. Anesthesiology. 2013;118(1):173-180.

Gutierrez S, Liu B, Hayashida K, Houle TT, Eisenach JC. Reversal of peripheral nerve injury-induced hypersensitivity in the postpartum period: role of spinal oxytocin. Anesthesiology. 2013;118(1):152-159.

Hayashida K-i, Peters CM, Gutierrez S, Eisenach JC. Depletion of endogenous noradrenaline does not prevent spinal cord plasticity following peripheral nerve injury. J Pain. 2012;13(1):49-57.

Hayashida K-i, Kimura M, Yoshizumi M, Hobo S, Obata H, Eisenach JC. Ondansetron reverses antihypersensitivity from clonidine in rats after peripheral nerve injury: role of gamma-aminobutyric acid in alpha2-adrenoceptor and 5-HT3 serotonin receptor analgesia. Anesthesiology. 2012;117(2):389-398.

Peters CM, Hayashida K-i, Ewan EE, Nakajima K, Obata H, Xu Q, Yaksh TL, Eisenach JC. Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat. Brain Res. 2010;1352():83-93.

Obata H, Hayashida K, Nakajima K, Saito S. [Alpha2 adrenergic receptors as a target for treatment of chronic pain ] [Japanese]. Pain Clinic (Japan). 2009;30():S233-S242.

Hayashida K, Eisenach JC. Multiplicative interactions to enhance gabapentin to treat neuropathic pain. Eur J Pharmacol. 2008;598(1-3):21-26.

Hayashida K-i, Obata H, Nakajima K, Eisenach JC. Gabapentin acts within the locus coeruleus to alleviate neuropathic pain. Anesthesiology. 2008;109(6):1077-1084.

Obata H, Hayashida KI. [Alpha2 adrenergic receptors as a target for treatment of chronic pain] [Japanese]. Pain Clinic (Japan). 2008;29(2):239-249.

Obata H, Hayashida KI. [Drug treatment for CRPS: gabapentin and antidepressants] [Japanese]. Pain Clinic (Japan). 2008;29(9):1189-1197.

Hayashida K, DeGoes S, Curry R, Eisenach JC. Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery. Anesthesiology. 2007;106(3):557-562.

Brett K, Parker R, Wittenauer S, Hayashida K, Young T, Vincler M. Impact of chronic nicotine on sciatic nerve injury in the rat. J Neuroimmunol. 2007;186(1-2):37-44.

Clayton BA, Hayashida K-i, Childers SR, Xiao R, Eisenach JC. Oral donepezil reduces hypersensitivity after nerve injury by a spinal muscarinic receptor mechanism. Anesthesiology. 2007;106(5):1019-1025.

Obata H, Hayashida K. Alpha2-adrenergic receptors in the dorsal horn of the spinal cord--their function and the descending inhibitory systems [Japanese]. Masui. 2007;56(Suppl):S161-S171.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Anesthesiology

Kenichiro Hayashida, D.V.M., Ph.D.

Kenichiro Hayashida, D.V.M., Ph.D.

Assistant Professor, Anesthesiology

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