Kenichiro Hayashida, D.V.M., Ph.D.Wake Forest School of Medicine

Kenichiro Hayashida, D.V.M., Ph.D.

Assistant Professor,

Contact Information

Academic: 336-716-3452


Additional Languages


Education & Training

  • D.V.M., Hokkaido University School of Veterinary Medicine, 1996
  • Ph.D., Yamaguchi Univ Graduate Sch of Veterinary Medicine, 2004
  • Fellowship, Pain Medicine, WFU School of Medicine, 2008


  • Am Pain Society
  • Int'l Assn For The Study Of Pa
  • Society for Neuroscience
Kenichiro Hayashida, D.V.M., Ph.D.

Kenichiro Hayashida, D.V.M., Ph.D.

Assistant Professor, Anesthesiology

Research Interests

neurosciences/behavior, pain

Contact Information

Academic: 336-716-3452


Recent Publications

Boada MD, Gutierrez S, Aschenbrenner CA, Houle TT, Hayashida KI, Ririe DG, Eisenach JC. Nerve injury induces a new profile of tactile and mechanical nociceptor input from undamaged peripheral afferents. J Neurophysiol. 2015;113(1):100-109.

Peters CM, Hayashida KI, Suto T, Houle TT, Aschenbrenner CA, Martin TJ, Eisenach JC. Individual differences in acute pain-induced endogenous analgesia predict time to resolution of postoperative pain in the rat. Anesthesiology. 2015;122(4):895-907.

Ding H, Hayashida K, Suto T, Sukhtankar DD, Kimura M, Mendenhall V, Ko MC. Supraspinal actions of nociceptin/orphanin FQ, morphine and substance P in regulating pain and itch in non-human primates. Br J Pharmacol. 2015;172(13):3302-3312.

Hayashida K, Kimura M, Peters C, Eisenach J. Down-regulation of astroglial glutamate transporters in the locus coeruleus contributes to impairment of endogenous analgesia in rats after peripheral nerve injury [abstract]. J Pain. 2015;16(4 Suppl 1):S50.

Rizzi A, Sukhtankar DD, Ding H, Hayashida K, Ruzza C, Guerrini R, Calo G, Ko MC. Spinal antinociceptive effects of the novel NOP receptor agonist PWT2-nociceptin/orphanin FQ in mice and monkeys. Br J Pharmacol. 2015;172(14):3661-3670.

Kimura M, Suto T, Morado-Urbina CE, Peters CM, Eisenach JC, Hayashida KI. Impaired pain-evoked analgesia after nerve injury in rats reflects altered glutamate regulation in the locus coeruleus. Anesthesiology. 2015;123(4):899-908.

Suto T, Severino AL, Eisenach JC, Hayashida KI. Gabapentin increases extracellular glutamatergic level in the locus coeruleus via astroglial glutamate transporter-dependent mechanisms. Neuropharmacology. 2014;81():95-100.

Suto T, Eisenach JC, Hayashida KI. Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain. Pain. 2014;155(10):1935-1942.

Danilo Boada M, Martin TJ, Peters CM, Hayashida K, Harris MH, Houle TT, Boyden ES, Eisenach JC, Ririe DG. Fast-conducting mechanoreceptors contribute to withdrawal behavior in normal and nerve injured rats. Pain. 2014;155(12):2646-2655.

Gutierrez S, Hayashida K, Eisenach JC. The puerperium alters spinal cord plasticity following peripheral nerve injury. Neuroscience. 2013;228():301-308.

Kimura M, Hayashida K, Eisenach JC, Saito S, Obata H. Relief of hypersensitivity after nerve injury from systemic donepezil involves spinal cholinergic and gamma-aminobutyric acid mechanisms. Anesthesiology. 2013;118(1):173-180.

Gutierrez S, Liu B, Hayashida K, Houle TT, Eisenach JC. Reversal of peripheral nerve injury-induced hypersensitivity in the postpartum period: role of spinal oxytocin. Anesthesiology. 2013;118(1):152-159.

Yoshizumi M, Eisenach JC, Hayashida K. Valproate prevents dysregulation of spinal glutamate and reduces the development of hypersensitivity in rats after peripheral nerve injury. J Pain. 2013;14(11):1485-1491.

Hayashida K. Substance P-saporin for bone cancer pain in dogs: can man's best friend solve the lost in translation problem in analgesic development? [editorial]. Anesthesiology. 2013;119(5):999-1000.

Hayashida K-i, Peters CM, Gutierrez S, Eisenach JC. Depletion of endogenous noradrenaline does not prevent spinal cord plasticity following peripheral nerve injury. J Pain. 2012;13(1):49-57.

Yoshizumi M, Eisenach JC, Hayashida K-i. Riluzole and gabapentinoids activate glutamate transporters to facilitate glutamate-induced glutamate release from cultured astrocytes. Eur J Pharmacol. 2012;677(1-3):87-92.

Hobo S, Hayashida K-i, Eisenach JC. Oxytocin inhibits the membrane depolarization-induced increase in intracellular calcium in capsaicin sensitive sensory neurons: a peripheral mechanism of analgesic action. Anesth Analg. 2012;114(2):442-449.

Yoshizumi M, Parker RA, Eisenach JC, Hayashida K-i. Gabapentin inhibits gamma-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats. Anesthesiology. 2012;116(6):1347-1353.

Hayashida K-i, Kimura M, Yoshizumi M, Hobo S, Obata H, Eisenach JC. Ondansetron reverses antihypersensitivity from clonidine in rats after peripheral nerve injury: role of gamma-aminobutyric acid in alpha2-adrenoceptor and 5-HT3 serotonin receptor analgesia. Anesthesiology. 2012;117(2):389-398.

Hayashida K-i, Eisenach JC. A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats with peripheral nerve injury. J Pain. 2011;12(1):94-100.

Hobo S, Eisenach JC, Hayashida K-i. Up-regulation of spinal glutamate transporters contributes to anti-hypersensitive effects of valproate in rats after peripheral nerve injury. Neurosci Lett. 2011;502(1):52-55.

Hayashida K-i, Parker RA, Eisenach JC. Activation of glutamate transporters in the locus coeruleus paradoxically activates descending inhibition in rats. Brain Res. 2010;1317():80-86.

Hayashida K-i, Eisenach JC. Spinal alpha 2-adrenoceptor-mediated analgesia in neuropathic pain reflects brain-derived nerve growth factor and changes in spinal cholinergic neuronal function. Anesthesiology. 2010;113(2):406-412.

Peters CM, Hayashida K-i, Ewan EE, Nakajima K, Obata H, Xu Q, Yaksh TL, Eisenach JC. Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat. Brain Res. 2010;1352():83-93.

Obata H, Hayashida K, Nakajima K, Saito S. [Alpha2 adrenergic receptors as a target for treatment of chronic pain ] [Japanese]. Pain Clinic (Japan). 2009;30():S233-S242.

Hayashida K, Clayton BA, Johnson JE, Eisenach JC. Brain derived nerve growth factor induces spinal noradrenergic fiber sprouting and enhances clonidine analgesia following nerve injury in rats. Pain. 2008;136(3):348-355.

Hayashida K, Eisenach JC. Multiplicative interactions to enhance gabapentin to treat neuropathic pain. Eur J Pharmacol. 2008;598(1-3):21-26.

Hayashida K-i, Obata H, Nakajima K, Eisenach JC. Gabapentin acts within the locus coeruleus to alleviate neuropathic pain. Anesthesiology. 2008;109(6):1077-1084.

Obata H, Hayashida KI. [Alpha2 adrenergic receptors as a target for treatment of chronic pain] [Japanese]. Pain Clinic (Japan). 2008;29(2):239-249.

Obata H, Hayashida KI. [Drug treatment for CRPS: gabapentin and antidepressants] [Japanese]. Pain Clinic (Japan). 2008;29(9):1189-1197.

Hayashida K, DeGoes S, Curry R, Eisenach JC. Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery. Anesthesiology. 2007;106(3):557-562.

Brett K, Parker R, Wittenauer S, Hayashida K, Young T, Vincler M. Impact of chronic nicotine on sciatic nerve injury in the rat. J Neuroimmunol. 2007;186(1-2):37-44.

Clayton BA, Hayashida K-i, Childers SR, Xiao R, Eisenach JC. Oral donepezil reduces hypersensitivity after nerve injury by a spinal muscarinic receptor mechanism. Anesthesiology. 2007;106(5):1019-1025.

Hayashida K-i, Parker R, Eisenach JC. Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil. Anesthesiology. 2007;106(6):1213-1219.

Obata H, Hayashida K. Alpha2-adrenergic receptors in the dorsal horn of the spinal cord--their function and the descending inhibitory systems [Japanese]. Masui. 2007;56(Suppl):S161-S171.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Anesthesiology

Kenichiro Hayashida, D.V.M., Ph.D.

Kenichiro Hayashida, D.V.M., Ph.D.

Assistant Professor, Anesthesiology

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