Ashok N. Hegde, D.Phil., Associate Professor Neurobiology and Anatomy

Ashok N. Hegde, Ph.D.

Professor, Neurobiology & Anatomy

Contact Information

Academic: 336-716-1372 | Department: 336-716-1372

Email: ahegde@wakehealth.edu

Education & Training

Ph.D., Free Standing Institute-India , 1990
Fellowship, Neurobiology, Columbia University College Physicians & Surgeons, 1994

Ashok N. Hegde, Ph.D.

Professor, Neurobiology & Anatomy

Research Interests

cognition/learning, neurosciences/behavior

Contact Information

Academic: 336-716-1372 | Department: 336-716-1372

Email: ahegde@wakehealth.edu

Recent Publications

Bach SV, Upadhya SC, Hedge AN. Novel epigenetic roles of the proteasome in long-term synaptic plasticity [abstract]. Soc Neurosci Abstr. 2012;2012(Neuroscience Meeting Planner):.

Hegde AN, Upadhya SC, Bach SV, Haynes KA, Dong C. Molecular correlates of early L-LTP enhancement mediated by proteasome inhibition [abstract]. Soc Neurosci Abstr. 2012;2012(Neuroscience Meeting Planner):.

Hegde AN, Upadhya SC. Role of ubiquitin-proteasome-mediated proteolysis in nervous system disease. Biochim Biophys Acta. 2011;1809(2):128-140.

Upadhya SC, Smith TK, Brennan PA, Mychaleckyj JC, Hegde AN. Expression profiling reveals differential gene induction underlying specific and non-specific memory for pheromones in mice. Neurochem Int. 2011;59(6):787-803.

Ding L, Styblo M, Drobna Z, Hegde A. The mRNA expression level of the longest RGS4 splice variant is associated with single nucleotide polymorphisms [abstract]. Soc Neurosci Abstr. 2011;2011(Neuroscience Meeting Planner):.

Hegde AN. Ubiquitin-dependent protein degradation In: Mander L, Lui H-W, eds. Comprehensive natural products II: chemistry and biology, vol 5. Oxford (England): Elsevier;2010: 699-752.

Hegde AN. The ubiquitin-proteasome pathway and synaptic plasticity. Learn Mem. 2010;17(7):314-327.

Nesterova S, Upadhya S, Hegde AN. Blockade of transcription by proteasome inhibition during maintenance of late phase long-term potentiation [abstract]. Soc Neurosci Abstr. 2010;2010(Neuroscience Meeting Planner):.

Hegde AN, Dong C. Proteasome inhibition enhances the induction of late phase long-term potentiation by stabilizing newly translated proteins [abstract]. Soc Neurosci Abstr. 2010;2010(Neuroscience Meeting Planner):.

Ding L, Hegde AN. Expression of RGS4 splice variants in dorsolateral prefrontal cortex of schizophrenic and bipolar disorder patients. Biol Psychiatry. 2009;65(6):541-545.

Hedge AN.Ubiquitin-proteasome system and plasticity

Dong C, Godwin DW, Brennan PA, Hegde AN. Protein kinase Calpha mediates a novel form of plasticity in the accessory olfactory bulb. Neuroscience. 2009;163(3):811-824.

Upadhya SC, Smith TK, Hegde AN. Protein kinase C-mediated phosphorylation is critical for CREB repressor ubiquitination during induction of long-term facilitation [abstract]. Soc Neurosci Abstr. 2009;2009(Neuroscience Meeting Planner):.

Hegde AN, Godwin DW, Brennan PA, Dong C. Coincidence detection by protein kinase Calpha in the accessory olfactory bulb suggests a model for a novel form of synaptic plasticity underlying single-trial learning [abstract]. Soc Neurosci Abstr. 2009;2009(Neuroscience Meeting Planner):.

Dong C, Upadhya SC, Ding L, Smith TK, Hegde AN. Proteasome inhibition enhances the induction and impairs the maintenance of late-phase long-term potentiation. Learn Mem. 2008;15(5):335-347.

Skinner CB, Upadhya SC, Smith TK, Turner CP, Hegde AN. Signal transduction and gene expression in cultured accessory olfactory bulb neurons. Neuroscience. 2008;157(2):340-348.

Ding L, Hegde A. RGS4 splice variants are differentially expressed in dorsolateral prefrontal cortex of schizophrenic and bipolar disorder patients [abstract]. Soc Neurosci Abstr. 2008;2008(Neuroscience Meeting Planner):.

Hegde AN. Proteolysis and synaptic plasticity In: Sweatt JD, Byrne JH, eds. Learning and memory: a comprehensive reference, vol 4: molecular mechanisms of memory. San Diego: Elsevier;2008: 525-546.

Ding L, Mychaleckyj JC, Hegde AN. Full length cloning and expression analysis of splice variants of regulator of G-protein signaling RGS4 in human and murine brain. Gene. 2007;401(1-2):46-60.

Hegde AN, Upadhya SC. The ubiquitin-proteasome pathway in health and disease of the nervous system. Trends Neurosci. 2007;30(11):587-595.

Upadhya SC, Hegde AN. Role of the ubiquitin proteasome system in Alzheimer's disease. BMC Biochem. 2007;8(Suppl 1):S12.

Ding L, Mychaleckyj JC, Hegde A. Splice variants of regulator of G-protein signaling RGS4 in human and murine brain [abstract]. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.

Hegde AN, Upadhya SC, Ding L, Smith TK, Dong C. The proteasome plays differential spatial and temporal roles in late phase long-term potentiation [abstract]. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.

Skinner CB, Hegde AN. Expression of genes encoding signaling molecules in the female mouse accessory olfactory bulb [abstract]. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.

Upadhya SC, Smith TK, Hegde AN. Induction and nuclear translocation of a proteasome regulatory subunit during long-term memory [abstract]. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.