David M. Herrington, M.D.Wake Forest School of Medicine

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David M. Herrington, M.D.


Clinical Interests

Heart Disease in Women, Cardiac Catheterization, Cardiology (clinical), Preventive and Rehabilitative Cardiology

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New Patient Appointments: 336-716-WAKE
Returning Patient Appointments: 336-716-6674
Department: 336-716-9124

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Education & Training

  • B.S., Davidson College, 1979
  • M.D., University of North Carolina School of Medicine, 1983
  • M.H.S., Johns Hopkins University, 1989
  • Internship, Internal Medicine, Johns Hopkins Affil Hosps, 1984
  • Residency, Internal Medicine, Johns Hopkins Affil Hosps, 1986
  • Fellowship, Johns Hopkins Affil Hosps, 1988
  • Fellowship, Johns Hopkins Affil Hosps, 1990

Board Certifications

  • American Board of Internal Medicine, Cardiovascular Disease
  • American Board of Internal Medicine, Internal Medicine


  • American College of Cardiology
  • Am Coll Of Physicians
  • Am Gerontological Society
  • Aha - Council On Epidemiology

NPI Number

  • 1932184215
David M. Herrington, M.D.

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No Rating Available
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David M. Herrington, M.D.

Professor, Cardiology

Research Interests

atherosclerosis/thrombosis, biotechnology, cardiac function, cell growth, differentiation,d, computer science, diabetes, education/training (all f, t,, epidemiology, genetics/genome, genomics and proteomics, minority health issues, prevention, vascular diseases

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Academic: 336-716-4950 | Department: 336-716-9124

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Recent Publications

McKeown NM, Hruby A, Landberg R, Herrington DM, Lichtenstein AH. Plasma alkylresorcinols, biomarkers of whole-grain intake, are not associated with progression of coronary artery atherosclerosis in postmenopausal women with coronary artery disease. Public Health Nutr. 2016;19(2):326-331.

Shah AD, Kandula NR, Lin F, Allison MA, Carr J, Herrington D, Liu K, Kanaya AM. Less favorable body composition and adipokines in South Asians compared with other US ethnic groups: results from the MASALA and MESA studies. Int J Obes (Lond). 2016;40(4):639-645.

Mahler SA, Riley RF, Russell GB, Hiestand BC, Hoekstra JW, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Bringolf J, Elliott SB, Herrington DM, Burke GL, Miller CD. Adherence to an accelerated diagnostic protocol for chest pain: secondary analysis of the HEART Pathway randomized trial. Acad Emerg Med. 2016;23(1):70-77.

Wang N, Hoffman EP, Chen L, Chen L, Zhang Z, Liu C, Yu G, Herrington DM, Clarke R, Wang Y. Mathematical modelling of transcriptional heterogeneity identifies novel markers and subpopulations in complex tissues. Sci Rep. 2016;6():18909.

Yeboah J, Young R, McClelland RL, Delaney JC, Polonsky TS, Dawood FZ, Blaha MJ, Miedema MD, Sibley CT, Carr JJ, Burke GL, Goff DC Jr, Psaty BM, Greenland P, Herrington DM. Utility of nontraditional risk markers in atherosclerotic cardiovascular disease risk assessment. J Am Coll Cardiol. 2016;67(2):139-147.

Mahler SA, Burke GL, Duncan PW, Case LD, Herrington DM, Riley RF, Wells BJ, Hiestand BC, Miller CD. HEART pathway accelerated diagnostic protocol implementation: prospective pre-post interrupted time series design and methods. JMIR Res Protoc. 2016;5(1):e10.

Li T, Cheng HJ, Ohte N, Hasegawa H, Morimoto A, Herrington D, Little W [deceased], Li W, Cheng CP. C-type natriuretic peptide improves left ventricular functional performance at rest and restores normal exercise responses after heart failure. J Pharmacol Exp Ther. 2016;357(3):545-553.

Yeboah J, Rodriguez CJ, Qureshi W, Liu S, Carr JJ, Lima JA, Hundley WG, Herrington DM. Prognosis of low normal left ventricular ejection fraction in an asymptomatic population-based adult cohort: the Multiethnic Study of Atherosclerosis. J Card Fail. 2016;():.

Stopyra JP, Miller CD, Hiestand BC, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Riley RF, Russell GB, Burke GL, Herrington D, Hoekstra JW, Mahler SA. Chest pain risk stratification: a comparison of the 2-hour accelerated diagnostic protocol (ADAPT) and the HEART Pathway. Crit Pathw Cardiol. 2016;15(2):46-49.

Ahmed HM, Miller M, Nasir K, McEvoy JW, Herrington D, Blumenthal RS, Blaha MJ. Primary low level of high-density lipoprotein cholesterol and risks of coronary heart disease, cardiovascular disease, and death: results from the Multi-Ethnic Study of Atherosclerosis. Am J Epidemiol. 2016;183(10):875-883.

Almahmoud MF, Herrington D, Hundley W, Jordan J, Kestenbaum B, Katz R, Michos E, Liu CY, Venkatesh BA, Lima J. Fibroblast growth factor-23 and cardiac MRI indices of myocardial fibrosis in the Multi-ethnic Study of Atherosclerosis [abstract]. J Am Coll Cardiol. 2016;67(13 Suppl):1684.

Chahal H, Bluemke DA, Wu CO, McClelland R, Liu K, Shea SJ, Burke G, Balfour P, Herrington D, Shi P, Post W, Olson J, Watson KE, Folsom AR, Lima JA. Heart failure risk prediction in the Multi-Ethnic Study of Atherosclerosis. Heart. 2015;101(1):58-64.

Chotenimitkhun R, D'Agostino R Jr, Lawrence JA, Hamilton CA, Jordan JH, Vasu S, Lash TL, Yeboah J, Herrington DM, Hundley WG. Chronic statin administration may attenuate early anthracycline-associated declines in left ventricular ejection function. Can J Cardiol. 2015;31(3):302-307.

Tian Y, Zhang B, Hoffman EP, Clarke R, Zhang Z, Shih IeM, Xuan J, Herrington DM, Wang Y. KDDN: an open-source Cytoscape app for constructing differential dependency networks with significant rewiring. Bioinformatics. 2015;31(2):287-289.

Mahler SA, Riley RF, Hiestand BC, Russell GB, Hoekstra JW, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Elliott SB, Herrington DM, Burke GL, Miller CD. The HEART pathway randomized trial: identifying emergency department patients with acute chest pain for early discharge. Circ Cardiovasc Qual Outcomes. 2015;8(2):195-203.

O'Neal WT, Soliman EZ, Qureshi W, Alonso A, Heckbert SR, Herrington D. Sustained pre-hypertensive blood pressure and incident atrial fibrillation: the Multi-Ethnic Study of Atherosclerosis. J Am Soc Hypertens. 2015;9(3):191-196.

Yeboah J, Sillau S, Delaney JC, Blaha MJ, Michos ED, Young R, Qureshi WT, McClelland R, Burke GL, Psaty BM, Herrington DM. Implications of the new American College of Cardiology/American Heart Association cholesterol guidelines for primary atherosclerotic cardiovascular disease event prevention in a multi ethnic cohort: Multi-Ethnic Study of Atherosclerosis (MESA). Am Heart J. 2015;169(3):387-395.e3.

Reynolds LM, Ding J, Taylor JR, Lohman K, Soranzo N, de la Fuente A, Liu TF, Johnson C, Barr RG, Register TC, Donohue KM, Talor MV, Cihakova D, Gu C, Divers J, Siscovick D, Burke G, Post W, Shea S, Jacobs DR Jr, Hoeschele I, McCall CE,. Transcriptomic profiles of aging in purified human immune cells. BMC Genomics. 2015;16(1):333.

Manichaikul A, Wang XQ, Musani SK, Herrington DM, Post WS, Wilson JG, Rich SS, Rodriguez A. Association of the lipoprotein receptor SCARB1 common missense variant rs4238001 with incident coronary heart disease. PLoS One. 2015;10(5):e0125497.

Chacko BG, Edwards MS, Sharrett AR, Qureshi WT, Klein BE, Klein R, Herrington DM, Soliman EZ. Microvasculature and incident atrioventricular conduction abnormalities in the Multi-Ethnic Study of Atherosclerosis (MESA). Vasc Med. 2015;20(5):417-423.

Ding J, Reynolds LM, Zeller T, Muller C, Mstat KL, Nicklas BJ, Kritchevsky SB, Huang Z, Fuente A, Soranzo N, Settlage RE, Chuang CC, Howard T, Xu N, Goodarzi MO, Ida Chen YD, Rotter JI, Siscovick DS, Parks JS, Murphy S, Jacobs DR Jr,. Alterations of a cellular cholesterol metabolism network are a molecular feature of obesity-related type 2 diabetes and cardiovascular disease. Diabetes. 2015;64(10):3464-3474.

Yeboah J, Polonsky TS, Young R, McClelland RL, Delaney JC, Dawood F, Blaha MJ, Miedema MD, Sibley CT, Carr JJ, Burke GL, Goff DC Jr, Psaty BM, Greenland P, Herrington DM. Utility of nontraditional risk markers in individuals ineligible for statin therapy according to the 2013 American College of Cardiology/American Heart Association cholesterol guidelines. Circulation. 2015;132(10):916-922.

Reynolds LM, Wan M, Ding J, Taylor JR, Lohman K, Su D, Bennett BD, Porter DK, Gimple R, Pittman GS, Wang X, Howard TD, Siscovick D, Psaty BM, Shea S, Burke GL, Jacobs DR Jr, Rich SS, Hixson JE, Stein JH, Stunnenberg H, Barr RG,. DNA methylation of the aryl hydrocarbon receptor repressor associations with cigarette smoking and subclinical atherosclerosis. Circ Cardiovasc Genet. 2015;8(5):707-716.

Salfati E, Nandkeolyar S, Fortmann SP, Sidney S, Hlatky MA, Quertermous T, Go AS, Iribarren C, Herrington DM, Goldstein BA, Assimes TL. Susceptibility loci for clinical CAD and subclinical coronary atherosclerosis throughout the life-course. Circ Cardiovasc Genet. 2015;8(6):803-811.

Soliman EZ, Safford MM, Muntner P, Khodneva Y, Dawood FZ, Zakai NA, Thacker EL, Judd S, Howard VJ, Howard G, Herrington DM, Cushman M. Atrial fibrillation and the risk of myocardial infarction. JAMA Intern Med. 2014;174(1):E107-E114.

Yeboah J, Herrington DM. Intermediate end point cardiovascular clinical trials: an excellent idea based on an obsolete paradigm. Expert Rev Cardiovasc Ther. 2014;12(2):161-165.

Gordon AS, Tabor HK, Johnson AD, Snively BM, Assimes TL, Auer PL, Ioannidis JP, Peters U, Robinson JG, Sucheston LE, Wang D, Sotoodehnia N, Rotter JI, Psaty BM, Jackson RD, Herrington DM, O'Donnell CJ, Reiner AP, Rich SS, Rieder MJ,. Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome dataset. Hum Mol Genet. 2014;23(8):1957-1963.

Bradley RD, Fitzpatrick AL, Jacobs DR Jr, Lee DH, Swords Jenny N, Herrington D. Associations between gamma-glutamyltransferase (GGT) and biomarkers of atherosclerosis: the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2014;233(2):387-393.

Whitman IR, Patel VV, Soliman EZ, Bluemke DA, Praestgaard A, Jain A, Herrington D, Lima JA, Kawut SM. Validity of the surface electrocardiogram criteria for right ventricular hypertrophy: the MESA-RV Study (Multi-Ethnic Study of Atherosclerosis-Right Ventricle). J Am Coll Cardiol. 2014;63(7):672-681.

Kalantarian S, Rimm EB, Herrington DM, Mozaffarian D. Dietary macronutrients, genetic variation, and progression of coronary atherosclerosis among women. Am Heart J. 2014;167(4):627-635.

Kanaya AM, Kandula NR, Ewing SK, Herrington D, Liu K, Blaha MJ, Srivastava S, Dave SS, Budoff MJ. Comparing coronary artery calcium among U.S. South Asians with four racial/ethnic groups: the MASALA and MESA studies. Atherosclerosis. 2014;234(1):102-107.

Cox AJ, Azeem A, Yeboah J, Soliman EZ, Aggarwal SR, Bertoni AG, Carr JJ, Freedman BI, Herrington DM, Bowden DW. Heart rate-corrected QT interval is an independent predictor of all-cause and cardiovascular mortality in individuals with type 2 diabetes: the Diabetes Heart Study. Diabetes Care. 2014;37(5):1454-1461.

Kanaya AM, Herrington D, Vittinghoff E, Ewing SK, Liu K, Blaha MJ, Dave SS, Qureshi F, Kandula NR. Understanding the high prevalence of diabetes in U.S. South Asians compared with four racial/ethnic groups: the MASALA and MESA studies. Diabetes Care. 2014;37(6):1621-1628.

Weiner SD, Ahmed HN, Jin Z, Cushman M, Herrington DM, Nelson JC, Di Tullio MR, Homma S. Systemic inflammation and brachial artery endothelial function in the Multi-Ethnic Study of Atherosclerosis (MESA). Heart. 2014;100(11):862-866.

Lange LA, Hu Y, Zhang H, Xue C, Schmidt EM, Tang ZZ, Bizon C, Lange EM, Smith JD, Turner EH, Jun G, Kang HM, Peloso G, Auer P, Li KP, Flannick J, Zhang J, Fuchsberger C, Gaulton K, Lindgren C, Locke A, Manning A, Sim X, Rivas MA, Holmen OL,. Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. Am J Hum Genet. 2014;94(2):233-245.

Yeboah J, Delaney JA, Nance R, McClelland RL, Polak JF, Sibley CT, Bertoni A, Burke GL, Carr JJ, Herrington DM. Mediation of cardiovascular risk factor effects through subclinical vascular disease: the Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2014;34(8):1778-1783.

Vaidya D, Bennett WL, Sibley CT, Polak JF, Herrington DM, Ouyang P. Association of parity with carotid diameter and distensibility Multi-Ethnic Study of Atherosclerosis. Hypertension. 2014;64(2):253-258.

Howard TD, Mathias RA, Seeds MC, Herrington DM, Hixson JE, Shimmin LC, Hawkins GA, Sellers M, Ainsworth HC, Sergeant S, Miller LR, Chilton FH. DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver. PLoS One. 2014;9(5):e97510.

Cox AJ, Hsu FC, Freedman BI, Herrington DM, Criqui MH, Carr JJ, Bowden DW. Contributors to mortality in high-risk diabetic patients in the Diabetes Heart Study. Diabetes Care. 2014;37(10):2798-2803.

Tian Y, Zhang B, Hoffman EP, Clarke R, Zhang Z, Shih IM, Xuan J, Herrington DM, Wang Y. Knowledge-fused differential dependency network models for detecting significant rewiring in biological networks. BMC Syst Biol. 2014;8(1):87.

Yeboah J, Erbel R, Delaney JC, Nance R, Guo M, Bertoni AG, Budoff M, Moebus S, Jockel KH, Burke GL, Wong ND, Lehmann N, Herrington DM, Mohlenkamp S, Greenland P. Development of a new diabetes risk prediction tool for incident coronary heart disease events: the Multi-Ethnic Study of Atherosclerosis and the Heinz Nixdorf Recall Study. Atherosclerosis. 2014;236(2):411-417.

Kandula NR, Kanaya AM, Liu K, Lee JY, Herrington D, Hulley SB, Persell SD, Lloyd-Jones DM, Huffman MD. Association of 10-year and lifetime predicted cardiovascular disease risk with subclinical atherosclerosis in South Asians: findings from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study. J Am Heart Assoc. 2014;3(5):e001117.

Qureshi W, Soliman EZ, Solomon SD, Alonso A, Arking DE, Shah A, Gupta DK, Wagenknecht LE, Herrington D. Risk factors for atrial fibrillation in patients with normal versus dilated left atrium (from the Atherosclerosis Risk in Communities study). Am J Cardiol. 2014;114(9):1368-1372.

Yeboah J, Bluemke DA, Hundley WG, Rodriguez CJ, Lima JA, Herrington DM. Left ventricular dilation and incident congestive heart failure in asymptomatic adults without cardiovascular disease: Multi-Ethnic Study of Atherosclerosis (MESA). J Card Fail. 2014;20(12):905-911.

Postmus I, Trompet S, Deshmukh HA, Barnes MR, Li X, Warren HR, Chasman DI, Zhou K, Arsenault BJ, Donnelly LA, Wiggins KL, Avery CL, Griffin P, Feng Q, Taylor KD, Li G, Evans DS, Smith AV, de Keyser CE, Johnson AD, de Craen AJ, Stott DJ, Buckley BM,. Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Nat Commun. 2014;5():5068.

Gibson AO, Blaha MJ, Arnan MK, Sacco RL, Szklo M, Herrington DM, Yeboah J. Coronary artery calcium and incident cerebrovascular events in an asymptomatic cohort. the MESA study. JACC Cardiovasc Imaging. 2014;7(11):1108-1115.

Reynolds LM, Taylor JR, Ding J, Lohman K, Johnson C, Siscovick D, Burke G, Post W, Shea S, Jacobs DR Jr, Stunnenberg H, Kritchevsky SB, Hoeschele I, McCall CE, Herrington DM, Tracy RP, Liu Y. Age-related variations in the methylome associated with gene expression in human monocytes and T cells. Nat Commun. 2014;5():5366.

Sellers MB, Divers J, Lu L, Xu J, Smith SC, Bowden DW, Herrington D, Freedman BI, Soliman EZ. Prevalence and determinants of electrocardiographic abnormalities in African Americans with type 2 diabetes. J Epidemiol Glob Health. 2014;4(4):289-296.

Cox AJ, Hsu FC, Agarwal S, Freedman BI, Herrington DM, Carr JJ, Bowden DW. Prediction of mortality using a multi-bed vascular calcification score in the Diabetes Heart Study. Cardiovasc Diabetol. 2014;13():160.

Kanaya A, Ewing S, Vittinghoff E, Herrington D, Tegeler C, Mills C, Kandula N. Acculturation and subclinical atherosclerosis among U.S. South Asians: findings from the MASALA study. J Clin Exp Res Cardiol. 2014;1(1):.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Cardiology

Clinical Interests

Heart Disease in Women, Cardiac Catheterization, Cardiology (clinical), Preventive and Rehabilitative Cardiology
David M. Herrington, M.D.

David M. Herrington, M.D.

Professor, Cardiology

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