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James W. Hoekstra, M.D.Wake Forest School of Medicine

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James W. Hoekstra, M.D.

Professor,

Clinical Interests

Cardiovascular Emergencies, Chest Pain, Emergency Medicine

Contact Information

Department: 336-716-4626

Email: jhoekstr@wakehealth.edu

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Education & Training

  • B.A., Hope College, 1980
  • M.D., Hope College, 1984
  • Internship, Emergency Medicine, U Cincinnati Hosp Grp, 1985
  • Residency, Emergency Medicine, U Cincinnati Hosp Grp, 1989

Board Certifications

  • American Board of Emergency Medicine, Emergency Medicine

Memberships

  • N.C. Chapter of A.C.E.P.
  • Ohio Chapter of A.C.E.P.
  • Physicians of the Ohio State U
  • Soc of Chest Pain Centers Prov
  • Phi Beta Kappa
  • Assn of Chair of Acad Emer Med
  • Columbus Medical Association
  • Alpha Omega Alpha
  • Emer Med Cardiac Res & Educ Gr
  • Forsyth County Medical Society

NPI Number

  • 1255315651
James W. Hoekstra, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

James W. Hoekstra, M.D.

Professor, Emergency Medicine

Research Interests

Acute Coronary Syndrome; Myocardial Infarction; Emergency Service, Hospital; Platelet Aggregation Inhibitors; Chest Pain
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Contact Information

Department: 336-716-4626

Email: jhoekstr@wakehealth.edu

Media Medical Expert »

Recent Publications

Impact of anticoagulation regimen prior to revascularization in patients with non-ST-segment elevation acute coronary syndromes: the ACUITY trial. Geisler T, Droppa M, Gawaz M, Steinhubl SR, Bertrand ME, Lincoff AM, Cequier AR, Desmet W, Rasmussen LH, Hoekstra JW, Bernstein D, Deliargyris EN, Mehran R, Stone GW.. Catheter Cardiovasc Interv. 2016;88(2):174-181.

Adherence to an accelerated diagnostic protocol for chest pain: secondary analysis of the HEART Pathway randomized trial. Mahler SA, Riley RF, Russell GB, Hiestand BC, Hoekstra JW, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Bringolf J, Elliott SB, Herrington DM, Burke GL, Miller CD.. Acad Emerg Med. 2016;23(1):70-77.

Comparison of the HEART and TIMI risk scores for suspected acute coronary syndrome in the emergency department. Sun BC, Laurie A, Fu R, Ferencik M, Shapiro M, Lindsell CJ, Diercks D, Hoekstra JW, Hollander JE, Kirk JD, Peacock WF, Anantharaman V, Pollack CV Jr.. Crit Pathw Cardiol. 2016;15(1):1-5.

Association of early stress testing with outcomes for emergency department evaluation of suspected acute coronary syndrome. Sun BC, Laurie A, Fu R, Ferencik M, Shapiro M, Lindsell CJ, Diercks D, Hoekstra JW, Hollander JE, Kirk JD, Peacock WF, Gibler WB, Anantharaman V, Pollack CV Jr.. Crit Pathw Cardiol. 2016;15(2):60-68.

Chest pain risk stratification: a comparison of the 2-hour accelerated diagnostic protocol (ADAPT) and the HEART Pathway. Stopyra JP, Miller CD, Hiestand BC, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Riley RF, Russell GB, Burke GL, Herrington D, Hoekstra JW, Mahler SA.. Crit Pathw Cardiol. 2016;15(2):46-49.

The HEART pathway randomized trial: identifying emergency department patients with acute chest pain for early discharge. Mahler SA, Riley RF, Hiestand BC, Russell GB, Hoekstra JW, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Elliott SB, Herrington DM, Burke GL, Miller CD.. Circ Cardiovasc Qual Outcomes. 2015;8(2):195-203.

Performance of the EDACS-accelerated diagnostic pathway in a cohort of US patients with acute chest pain. Stopyra JP, Miller CD, Hiestand BC, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Riley RF, Russell GB, Hoekstra JW, Mahler SA.. Crit Pathw Cardiol. 2015;14(4):134-138.

Lessons in flying: crew resource management as a quality improvement method for acute coronary syndromes care. Levy PD, Dancy JN, Stowell SA, Hoekstra JW, Arthur CL, Wilson CH, Bednar JM, Dorman T, Hiestand B.. Crit Pathw Cardiol. 2014;13(1):36-42.

Avoidable utilization of the chest pain observation unit: evaluation of very-low-risk patients. Mahler SA, Burke GL, Goff DC Jr, Hiestand BC, Nicks BA, Hoekstra JW, Case LD, Miller CD.. Crit Pathw Cardiol. 2013;12(2):59-64.

Stress CMR reduces revascularization, hospital readmission, and recurrent cardiac testing in intermediate-risk patients with acute chest pain. Miller CD, Case LD, Little WC, Mahler SA, Burke GL, Harper EN, Lefebvre C, Hiestand B, Hoekstra JW, Hamilton CA, Hundley WG.. JACC Cardiovasc Imaging. 2013;6(7):785-794.

Anticoagulation with otamixaban and ischemic events in non-ST-segment elevation acute coronary syndromes: the TAO randomized clinical trial. Steg PG, Mehta SR, Pollack CV Jr, Bode C, Cohen M, French WJ, Hoekstra J, Rao SV, Ruzyllo W, Ruiz-Nodar JM, Sabate M, Widimsky P, Kiss RG, Navarro Estrada JL, Hod H, Kerkar P, Guneri S, Sezer M, Ruda M, Nicolau JC,.. JAMA. 2013;310(11):1145-1155.

Provider-directed imaging stress testing reduces health care expenditures in lower-risk chest pain patients presenting to the emergency department. Miller CD, Hoekstra JW, Lefebvre C, Blumstein H, Hamilton CA, Harper EN, Mahler S, Diercks DB, Neiberg R, Hundley WG.. Circ Cardiovasc Imaging. 2012;5(1):111-118.

Length of stay for observation unit chest pain patients tested with coronary computed tomography angiography compared to stress testing depends on time of emergency department presentation [abstract]. Mahler SA, Hiestand BC, Hoekstra JW, Goff DC, Miller CD.. Acad Emerg Med. 2012;19(Suppl 1):S152.

Comparison of an automated algorithm to expert physician interpretation of 80-lead body surface mapping in the evaluation of acute myocardial ischemia and infarction in patients presenting to the emergency department with chest pain:. Lefebvre CW, Krucoff MW, Hiestand BC, Chandra A, Cairns CB, Massaro J, Hoekstra J.. J Electrocardiol. 2012;45(6):702-707.

Self-reported cocaine use, emergency physician testing and outcomes in suspected acute coronary syndromes: a nested matched case-control study. Wang Y, Lindsell CJ, Pollack CV Jr, Hollander J, Diercks DB, Kirk JD, Anantharaman V, Gibler WB, Hoekstra J, Peacock WF.. BMJ Open. 2012;2(3):e000572.

Outcomes associated with small changes in normal-range cardiac markers. McMullin N, Lindsell CJ, Lei L, Mafi J, Jois-Bilowich P, Anantharaman V, Pollack CV Jr, Hollander JE, Gibler WB, Hoekestra JW, et al.. Am J Emerg Med. 2011;29(2):162-167.

The time dependence of antithrombin initiation in patients with non-ST-segment elevation acute coronary syndromes: subgroup analysis from the ACUITY trial. Diercks DB, Pollack CV Jr, Hollander JE, Blomkalns AL, Emerman CL, Rokos IC, Larson DM, Hoekstra JW, Mehran R, Stone GW.. Ann Emerg Med. 2011;57(3):204-212.

In emergency department patients with acute chest pain, stress cardiac MRI observation unit care reduces 1-year cardiac-related health care expenditures: a randomized trial [abstract]. Miller C, Hwang W, Case D, Hoekstra JW, Lefebvre C, Blumstein H, Hamilton CA, Harper EN, Hundley WG.. J Am Coll Cardiol. 2011;57(14 Suppl 1):E1187.

A randomized trial comparing stress cardiac MRI to conventional testing among observation unit patients with chest pain [abstract]. Miller CD, Hoekstra JW, Lefevbre C [sic] [Lefebvre C], Blumstein H, Hamilton CA, Harper EN, Mahler S, Diercks DB, Neiberg RH, Hundley WG.. Acad Emerg Med. 2011;18(Suppl 1):S12.

Coronary computed tomography angiography decreases length of stay in patients with acute chest pain compared to stress testing: does time of patient presentation affect this relationship? [abstract]. Mahler SA, Nawanaji-Enwerem J, Miller CD, Hoekstra JW, Goff DC.. J Am Coll Cardiol. 2011;57(14 Suppl 1):E666.

Is the HEART score predictive of major adverse cardiac events in a cohort of emergency department patients with low-risk chest pain? [abstract]. Mahler SA, Goff DC, Hoekstra JW, Miller CD.. Acad Emerg Med. 2011;18(5 Suppl 1):S17.

A report of quality improvement in the care of patients with acute coronary syndromes. Cannon CP, Hoekstra JW, Larson DM, Karcher RB, Mencia WA, Berry CA, Stowell SA.. Crit Pathw Cardiol. 2011;10(1):29-34.

Stress CMR imaging observation unit in the emergency department reduces 1-year medical care costs in patients with acute chest pain: a randomized study for comparison with inpatient care. Miller CD, Hwang W, Case D, Hoekstra JW, Lefebvre C, Blumstein H, Hamilton CA, Harper EN, Hundley WG.. JACC Cardiovasc Imaging. 2011;4(8):862-870.

Can the HEART score safely reduce stress testing and cardiac imaging in patients at low risk for major adverse cardiac events?. Mahler SA, Hiestand BC, Goff DC Jr, Hoekstra JW, Miller CD.. Crit Pathw Cardiol. 2011;10(3):128-133.

Variability of emergency physicians' utilization of chest pain units for 'very low risk' chest pain patients [abstract]. Mahler SA, Goff DC, Hoekstra JW, Miller CD.. Ann Emerg Med. 2011;58(4 Suppl):S190.

Take heart: a one-on-one peer-based strategy to improve acute coronary syndrome patient care. Stowell SA, Cannon CP, Hoekstra JW, Peterson ED, Miller SC.. Crit Pathw Cardiol. 2011;10(4):164-168.

The future of emergency medicine: an evolutionary perspective. Sklar DP, Handel DA, Hoekstra J, Baren JM, Zink B, Hedges JR.. Acad Med. 2010;85(3):490-495.

Risk stratification and application of guidelines for non-ST-segment elevation acute coronary syndromes in the emergency department [CME]. Lefebvre CW, Hoekstra J.. Thrombosis Clinic. 2010;3(2):9-20.

Physician practice patterns in acute coronary syndromes: an initial report of an individual quality improvement program. Cannon CP, Hoekstra JW, Larson DM, Carter RD, Cornish J, Karcher RB, Mencia WA, Berry CA, Stowell SA.. Crit Pathw Cardiol. 2010;9(1):23-29.

Stress cardiac magnetic resonance imaging with observation unit care reduces cost for patients with emergent chest pain: a randomized trial. Miller CD, Hwang W, Hoekstra JW, Case D, Lefebvre C, Blumstein H, Hiestand B, Hamilton CA, Harper EN, Hundley WG, et al.. Ann Emerg Med. 2010;56(3):209-219.

Incremental benefit of 80-lead electrocardiogram body surface mapping over the 12-lead electrocardiogram in the detection of acute coronary syndromes in patients without ST-elevation myocardial infarction:. O'Neil BJ, Hoekstra J, Pride YB, Lefebvre C, Diercks D, Peacock WF, Fermann GJ, Gibson CM, Pinto D, Giglio JF, et al.. Acad Emerg Med. 2010;17(9):932-939.

Impact of a statewide ST-segment-elevation myocardial infarction regionalization program on treatment times for women, minorities, and the elderly. Glickman SW, Granger CB, Ou F-S, O'Brien S, Lytle BL, Cairns CB, Mears G, Hoekstra JW, Garvey JL, Peterson ED, et al.. Circ Cardiovasc Qual Outcomes. 2010;3(5):514-521.

Six Sigma process utilization in reducing door-to-balloon time at a single academic tertiary care center. Kelly EW, Kelly JD, Hiestand B, Wells-Kiser K, Starling S, Hoekstra JW.. Prog Cardiovasc Dis. 2010;53(3):219-226.

Glycoprotein IIb-IIIa inhibitors in the emergency department for patients with non-ST-elevation acute coronary syndromes: principles and practices. Lefebvre CW, Hoekstra JW, Bonaca M, Giugliano R.. J Emerg Med. 2009;36(2):162-170.

Individual quality improvement in acute coronary syndromes: a performance improvement initiative. Cannon CP, Hoekstra JW, Larson DM, Mencia WA, Cornish J, Carter RD, Berry CA, Karcher RB.. Crit Pathw Cardiol. 2009;8(1):43-48.

Management of patients with unstable angina / non-ST-elevation myocardial infarction: a critical review of the 2007 ACC /AHA guidelines. Hoekstra J, Cohen M.. Int J Clin Pract. 2009;63(4):642-655.

Advanced age, antithrombotic strategy, and bleeding in non-ST-segment elevation acute coronary syndromes: results from the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) trial. Lopes RD, Alexander KP, Manoukian SV, Bertrand ME, Feit F, White HD, Pollack CV Jr, Hoekstra J, Gersh BJ, Stone GW, et al.. J Am Coll Cardiol. 2009;53(12):1021-1030.

Emergency physician high pretest probability for acute coronary syndrome correlates with adverse cardiovascular outcomes. Chandra A, Lindsell CJ, Limkakeng A, Djercks DB, Hoekstra JW, Hollander JE, Kirk JD, Peacock WF, Gibler WB, Pollack CV.. Acad Emerg Med. 2009;16(8):740-748.

Expert consensus on treatment strategies in non-ST-segment elevation acute coronary syndromes in patients undergoing percutaneous coronary intervention--an evidence-based review. Hoekstra J, Cohen M, Giugliano R, Granger CB, Gurbel PA, Hollander JE, Manoukian SV, Saucedo JF, Pollack CV Jr.. Am J Emerg Med. 2009;27(6):720-728.

Safety and efficacy of bivalirudin in high-risk patients admitted through the emergency department. Miller CD, Blomkalns AL, Gersh BJ, Pollack CV, Brogan GX, Diercks DB, Peacock WF, Stone GW, Hollander JE, Hoekstra JW, et al.. Acad Emerg Med. 2009;16(8):717-725.

Early objective identification of chest pain patients at very low risk of 30-day adverse outcomes [abstract]. Peacock W, Hoekstra J, Krucoff M, Diercks D, Fermann G, Clark C, Grines C, Jois-Bilowich P.. Ann Emerg Med. 2009;54(3 Suppl):S2.

Early treatment for non-ST-segment elevation acute coronary syndrome is associated with appropriate discharge care. Fermann GJ, Raja AS, Peterson ED, Roe MT, Hoekstra JW, Milford-Beland S, Diercks DB, Pollack CV Jr, Peacock WF, Summers R, et al.. Clin Cardiol. 2009;32(9):519-525.

The usage patterns of cardiac bedside markers employing point-of-care testing for troponin in non-ST-segment elevation acute coronary syndrome: results from CRUSADE. Takakuwa KM, Ou F-S, Peterson ED, Pollack CV Jr, Peacock WF, Hoekstra JW, Ohman EM, Gibler WB, Blomkalns AL, Roe MT.. Clin Cardiol. 2009;32(9):498-505.

Relation of patient age and mortality to reported contraindications to early beta-blocker use for non-ST-elevation acute coronary syndrome. LaPointe NMA, Chen AY, Roe MT, Cohen DJ, Diercks DB, Hoekstra JW, Fesmire FM, Gibler WB, Ohman EM, Peterson ED.. Am J Cardiol. 2009;104(10):1324-1329.

Acute detection of ST-elevation myocardial infarction missed on standard 12-Lead ECG with a novel 80-lead real-time digital body surface map: primary results from the multicenter OCCULT MI trial. Hoekstra JW, O'Neill BJ, Pride YB, Lefebvre C, Diercks DB, Peacock WF, Fermann GJ, Gibson CM, Pinto D, Giglio J, et al.. Ann Emerg Med. 2009;54(6):779-788.

Stress cardiac MRI in an observation unit setting reduces index hospitalization cost in ED patients with chest pain at intermediate risk for acute coronary syndromes [abstract]. Miller CD, Hwang W, Case D, Lefebvre C, Hiestand B, Diercks DB, Hamilton CA, Harper EN, Hoekstra JW, Hundley WG.. Circulation. 2009;120(18 Suppl 2):S337.

The association between frontal plane QRS/T angle and short-term adverse events in ED patients with chest pain [abstract]. McMullan J, Gallaher J, Askew K, Zhang Z-M, Hoekstra J, Miller C.. Acad Emerg Med. 2009;16(4 Suppl 1):S116.

Randomized comparison of observation unit plus stress cardiac MRI and hospital admission [abstract]. Miller CD, Hwang W, Hoekstra JW, Lefebvre C, Case D, Hundley WG.. J Cardiovasc Magn Reson. 2009;11(Suppl 1):0103.

The value of T-wave inversion in the diagnosis of an acute coronary syndrome [abstract]. Diercks D, Hoekstra J, Fermann G, O'Neil B, Amsterdam E, Lefebvre C, Kirk D, Krucoff M.. Acad Emerg Med. 2009;16(4 Suppl 1):S115.

LUMEN 2009 workshops highlight pertinent issues in STEMI interventions [news magazine article]. Mehta S, Hoekstra J, Myers JB, Nader R, Rokos I, Unger B, May ML.. Cath Lab Digest. 2009;17(2):.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Emergency Medicine

Clinical Interests

Cardiovascular Emergencies, Chest Pain, Emergency Medicine
James W. Hoekstra, M.D.

James W. Hoekstra, M.D.

Professor, Emergency Medicine

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