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James W. Hoekstra, M.D.Wake Forest School of Medicine

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James W. Hoekstra, M.D.

Professor,

Clinical Interests

Cardiovascular Emergencies, Chest Pain, Emergency Medicine

Contact Information

Department: 336-716-4626

Email: jhoekstr@wakehealth.edu

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Education & Training

  • B.A., Hope College, 1980
  • M.D., Hope College, 1984
  • Internship, Emergency Medicine, U Cincinnati Hosp Grp, 1985
  • Residency, Emergency Medicine, U Cincinnati Hosp Grp, 1989

Board Certifications

  • American Board of Emergency Medicine, Emergency Medicine

Memberships

  • N.C. Chapter of A.C.E.P.
  • Ohio Chapter of A.C.E.P.
  • Physicians of the Ohio State U
  • Soc of Chest Pain Centers Prov
  • Phi Beta Kappa
  • Assn of Chair of Acad Emer Med
  • Columbus Medical Association
  • Alpha Omega Alpha
  • Emer Med Cardiac Res & Educ Gr
  • Forsyth County Medical Society

NPI Number

  • 1255315651
James W. Hoekstra, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

James W. Hoekstra, M.D.

Professor, Emergency Medicine

Contact Information

Department: 336-716-4626

Email: jhoekstr@wakehealth.edu

Media Medical Expert »

Recent Publications

Mahler SA, Riley RF, Russell GB, Hiestand BC, Hoekstra JW, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Bringolf J, Elliott SB, Herrington DM, Burke GL, Miller CD. Adherence to an accelerated diagnostic protocol for chest pain: secondary analysis of the HEART Pathway randomized trial. Acad Emerg Med. 2016;23(1):70-77.

Sun BC, Laurie A, Fu R, Ferencik M, Shapiro M, Lindsell CJ, Diercks D, Hoekstra JW, Hollander JE, Kirk JD, Peacock WF, Anantharaman V, Pollack CV Jr. Comparison of the HEART and TIMI risk scores for suspected acute coronary syndrome in the emergency department. Crit Pathw Cardiol. 2016;15(1):1-5.

Sun BC, Laurie A, Fu R, Ferencik M, Shapiro M, Lindsell CJ, Diercks D, Hoekstra JW, Hollander JE, Kirk JD, Peacock WF, Gibler WB, Anantharaman V, Pollack CV Jr. Association of early stress testing with outcomes for emergency department evaluation of suspected acute coronary syndrome. Crit Pathw Cardiol. 2016;15(2):60-68.

Stopyra JP, Miller CD, Hiestand BC, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Riley RF, Russell GB, Burke GL, Herrington D, Hoekstra JW, Mahler SA. Chest pain risk stratification: a comparison of the 2-hour accelerated diagnostic protocol (ADAPT) and the HEART Pathway. Crit Pathw Cardiol. 2016;15(2):46-49.

Mahler SA, Riley RF, Hiestand BC, Russell GB, Hoekstra JW, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Elliott SB, Herrington DM, Burke GL, Miller CD. The HEART pathway randomized trial: identifying emergency department patients with acute chest pain for early discharge. Circ Cardiovasc Qual Outcomes. 2015;8(2):195-203.

Geisler T, Droppa M, Gawaz M, Steinhubl SR, Bertrand ME, Lincoff AM, Cequier AR, Desmet W, Rasmussen LH, Hoekstra JW, Bernstein D, Deliargyris EN, Mehran R, Stone GW. Impact of anticoagulation regimen prior to revascularization in patients with non-ST-segment elevation acute coronary syndromes: the ACUITY trial. Catheter Cardiovasc Interv. 2015;():.

Stopyra JP, Miller CD, Hiestand BC, Lefebvre CW, Nicks BA, Cline DM, Askew KL, Riley RF, Russell GB, Hoekstra JW, Mahler SA. Performance of the EDACS-accelerated diagnostic pathway in a cohort of US patients with acute chest pain. Crit Pathw Cardiol. 2015;14(4):134-138.

Levy PD, Dancy JN, Stowell SA, Hoekstra JW, Arthur CL, Wilson CH, Bednar JM, Dorman T, Hiestand B. Lessons in flying: crew resource management as a quality improvement method for acute coronary syndromes care. Crit Pathw Cardiol. 2014;13(1):36-42.

Mahler SA, Burke GL, Goff DC Jr, Hiestand BC, Nicks BA, Hoekstra JW, Case LD, Miller CD. Avoidable utilization of the chest pain observation unit: evaluation of very-low-risk patients. Crit Pathw Cardiol. 2013;12(2):59-64.

Miller CD, Case LD, Little WC, Mahler SA, Burke GL, Harper EN, Lefebvre C, Hiestand B, Hoekstra JW, Hamilton CA, Hundley WG. Stress CMR reduces revascularization, hospital readmission, and recurrent cardiac testing in intermediate-risk patients with acute chest pain. JACC Cardiovasc Imaging. 2013;6(7):785-794.

Steg PG, Mehta SR, Pollack CV Jr, Bode C, Cohen M, French WJ, Hoekstra J, Rao SV, Ruzyllo W, Ruiz-Nodar JM, Sabate M, Widimsky P, Kiss RG, Navarro Estrada JL, Hod H, Kerkar P, Guneri S, Sezer M, Ruda M, Nicolau JC,. Anticoagulation with otamixaban and ischemic events in non-ST-segment elevation acute coronary syndromes: the TAO randomized clinical trial. JAMA. 2013;310(11):1145-1155.

Miller CD, Hoekstra JW, Lefebvre C, Blumstein H, Hamilton CA, Harper EN, Mahler S, Diercks DB, Neiberg R, Hundley WG. Provider-directed imaging stress testing reduces health care expenditures in lower-risk chest pain patients presenting to the emergency department. Circ Cardiovasc Imaging. 2012;5(1):111-118.

Mahler SA, Hiestand BC, Hoekstra JW, Goff DC, Miller CD. Length of stay for observation unit chest pain patients tested with coronary computed tomography angiography compared to stress testing depends on time of emergency department presentation [abstract]. Acad Emerg Med. 2012;19(Suppl 1):S152.

Lefebvre CW, Krucoff MW, Hiestand BC, Chandra A, Cairns CB, Massaro J, Hoekstra J. Comparison of an automated algorithm to expert physician interpretation of 80-lead body surface mapping in the evaluation of acute myocardial ischemia and infarction in patients presenting to the emergency department with chest pain:. J Electrocardiol. 2012;45(6):702-707.

Wang Y, Lindsell CJ, Pollack CV Jr, Hollander J, Diercks DB, Kirk JD, Anantharaman V, Gibler WB, Hoekstra J, Peacock WF. Self-reported cocaine use, emergency physician testing and outcomes in suspected acute coronary syndromes: a nested matched case-control study. BMJ Open. 2012;2(3):e000572.

McMullin N, Lindsell CJ, Lei L, Mafi J, Jois-Bilowich P, Anantharaman V, Pollack CV Jr, Hollander JE, Gibler WB, Hoekestra JW, et al. Outcomes associated with small changes in normal-range cardiac markers. Am J Emerg Med. 2011;29(2):162-167.

Diercks DB, Pollack CV Jr, Hollander JE, Blomkalns AL, Emerman CL, Rokos IC, Larson DM, Hoekstra JW, Mehran R, Stone GW. The time dependence of antithrombin initiation in patients with non-ST-segment elevation acute coronary syndromes: subgroup analysis from the ACUITY trial. Ann Emerg Med. 2011;57(3):204-212.

Miller C, Hwang W, Case D, Hoekstra JW, Lefebvre C, Blumstein H, Hamilton CA, Harper EN, Hundley WG. In emergency department patients with acute chest pain, stress cardiac MRI observation unit care reduces 1-year cardiac-related health care expenditures: a randomized trial [abstract]. J Am Coll Cardiol. 2011;57(14 Suppl 1):E1187.

Miller CD, Hoekstra JW, Lefevbre C [sic] [Lefebvre C], Blumstein H, Hamilton CA, Harper EN, Mahler S, Diercks DB, Neiberg RH, Hundley WG. A randomized trial comparing stress cardiac MRI to conventional testing among observation unit patients with chest pain [abstract]. Acad Emerg Med. 2011;18(Suppl 1):S12.

Mahler SA, Nawanaji-Enwerem J, Miller CD, Hoekstra JW, Goff DC. Coronary computed tomography angiography decreases length of stay in patients with acute chest pain compared to stress testing: does time of patient presentation affect this relationship? [abstract]. J Am Coll Cardiol. 2011;57(14 Suppl 1):E666.

Mahler SA, Goff DC, Hoekstra JW, Miller CD. Is the HEART score predictive of major adverse cardiac events in a cohort of emergency department patients with low-risk chest pain? [abstract]. Acad Emerg Med. 2011;18(5 Suppl 1):S17.

Cannon CP, Hoekstra JW, Larson DM, Karcher RB, Mencia WA, Berry CA, Stowell SA. A report of quality improvement in the care of patients with acute coronary syndromes. Crit Pathw Cardiol. 2011;10(1):29-34.

Miller CD, Hwang W, Case D, Hoekstra JW, Lefebvre C, Blumstein H, Hamilton CA, Harper EN, Hundley WG. Stress CMR imaging observation unit in the emergency department reduces 1-year medical care costs in patients with acute chest pain: a randomized study for comparison with inpatient care. JACC Cardiovasc Imaging. 2011;4(8):862-870.

Mahler SA, Hiestand BC, Goff DC Jr, Hoekstra JW, Miller CD. Can the HEART score safely reduce stress testing and cardiac imaging in patients at low risk for major adverse cardiac events?. Crit Pathw Cardiol. 2011;10(3):128-133.

Mahler SA, Goff DC, Hoekstra JW, Miller CD. Variability of emergency physicians' utilization of chest pain units for 'very low risk' chest pain patients [abstract]. Ann Emerg Med. 2011;58(4 Suppl):S190.

Stowell SA, Cannon CP, Hoekstra JW, Peterson ED, Miller SC. Take heart: a one-on-one peer-based strategy to improve acute coronary syndrome patient care. Crit Pathw Cardiol. 2011;10(4):164-168.

Sklar DP, Handel DA, Hoekstra J, Baren JM, Zink B, Hedges JR. The future of emergency medicine: an evolutionary perspective. Acad Med. 2010;85(3):490-495.

Lefebvre CW, Hoekstra J. Risk stratification and application of guidelines for non-ST-segment elevation acute coronary syndromes in the emergency department [CME]. Thrombosis Clinic. 2010;3(2):9-20.

Cannon CP, Hoekstra JW, Larson DM, Carter RD, Cornish J, Karcher RB, Mencia WA, Berry CA, Stowell SA. Physician practice patterns in acute coronary syndromes: an initial report of an individual quality improvement program. Crit Pathw Cardiol. 2010;9(1):23-29.

Miller CD, Hwang W, Hoekstra JW, Case D, Lefebvre C, Blumstein H, Hiestand B, Hamilton CA, Harper EN, Hundley WG, et al. Stress cardiac magnetic resonance imaging with observation unit care reduces cost for patients with emergent chest pain: a randomized trial. Ann Emerg Med. 2010;56(3):209-219.

O'Neil BJ, Hoekstra J, Pride YB, Lefebvre C, Diercks D, Peacock WF, Fermann GJ, Gibson CM, Pinto D, Giglio JF, et al. Incremental benefit of 80-lead electrocardiogram body surface mapping over the 12-lead electrocardiogram in the detection of acute coronary syndromes in patients without ST-elevation myocardial infarction:. Acad Emerg Med. 2010;17(9):932-939.

Glickman SW, Granger CB, Ou F-S, O'Brien S, Lytle BL, Cairns CB, Mears G, Hoekstra JW, Garvey JL, Peterson ED, et al. Impact of a statewide ST-segment-elevation myocardial infarction regionalization program on treatment times for women, minorities, and the elderly. Circ Cardiovasc Qual Outcomes. 2010;3(5):514-521.

Kelly EW, Kelly JD, Hiestand B, Wells-Kiser K, Starling S, Hoekstra JW. Six Sigma process utilization in reducing door-to-balloon time at a single academic tertiary care center. Prog Cardiovasc Dis. 2010;53(3):219-226.

Lefebvre CW, Hoekstra JW, Bonaca M, Giugliano R. Glycoprotein IIb-IIIa inhibitors in the emergency department for patients with non-ST-elevation acute coronary syndromes: principles and practices. J Emerg Med. 2009;36(2):162-170.

Cannon CP, Hoekstra JW, Larson DM, Mencia WA, Cornish J, Carter RD, Berry CA, Karcher RB. Individual quality improvement in acute coronary syndromes: a performance improvement initiative. Crit Pathw Cardiol. 2009;8(1):43-48.

Hoekstra J, Cohen M. Management of patients with unstable angina / non-ST-elevation myocardial infarction: a critical review of the 2007 ACC /AHA guidelines. Int J Clin Pract. 2009;63(4):642-655.

Lopes RD, Alexander KP, Manoukian SV, Bertrand ME, Feit F, White HD, Pollack CV Jr, Hoekstra J, Gersh BJ, Stone GW, et al. Advanced age, antithrombotic strategy, and bleeding in non-ST-segment elevation acute coronary syndromes: results from the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) trial. J Am Coll Cardiol. 2009;53(12):1021-1030.

Chandra A, Lindsell CJ, Limkakeng A, Djercks DB, Hoekstra JW, Hollander JE, Kirk JD, Peacock WF, Gibler WB, Pollack CV. Emergency physician high pretest probability for acute coronary syndrome correlates with adverse cardiovascular outcomes. Acad Emerg Med. 2009;16(8):740-748.

Hoekstra J, Cohen M, Giugliano R, Granger CB, Gurbel PA, Hollander JE, Manoukian SV, Saucedo JF, Pollack CV Jr. Expert consensus on treatment strategies in non-ST-segment elevation acute coronary syndromes in patients undergoing percutaneous coronary intervention--an evidence-based review. Am J Emerg Med. 2009;27(6):720-728.

Miller CD, Blomkalns AL, Gersh BJ, Pollack CV, Brogan GX, Diercks DB, Peacock WF, Stone GW, Hollander JE, Hoekstra JW, et al. Safety and efficacy of bivalirudin in high-risk patients admitted through the emergency department. Acad Emerg Med. 2009;16(8):717-725.

Peacock W, Hoekstra J, Krucoff M, Diercks D, Fermann G, Clark C, Grines C, Jois-Bilowich P. Early objective identification of chest pain patients at very low risk of 30-day adverse outcomes [abstract]. Ann Emerg Med. 2009;54(3 Suppl):S2.

Fermann GJ, Raja AS, Peterson ED, Roe MT, Hoekstra JW, Milford-Beland S, Diercks DB, Pollack CV Jr, Peacock WF, Summers R, et al. Early treatment for non-ST-segment elevation acute coronary syndrome is associated with appropriate discharge care. Clin Cardiol. 2009;32(9):519-525.

Takakuwa KM, Ou F-S, Peterson ED, Pollack CV Jr, Peacock WF, Hoekstra JW, Ohman EM, Gibler WB, Blomkalns AL, Roe MT. The usage patterns of cardiac bedside markers employing point-of-care testing for troponin in non-ST-segment elevation acute coronary syndrome: results from CRUSADE. Clin Cardiol. 2009;32(9):498-505.

LaPointe NMA, Chen AY, Roe MT, Cohen DJ, Diercks DB, Hoekstra JW, Fesmire FM, Gibler WB, Ohman EM, Peterson ED. Relation of patient age and mortality to reported contraindications to early beta-blocker use for non-ST-elevation acute coronary syndrome. Am J Cardiol. 2009;104(10):1324-1329.

Hoekstra JW, O'Neill BJ, Pride YB, Lefebvre C, Diercks DB, Peacock WF, Fermann GJ, Gibson CM, Pinto D, Giglio J, et al. Acute detection of ST-elevation myocardial infarction missed on standard 12-Lead ECG with a novel 80-lead real-time digital body surface map: primary results from the multicenter OCCULT MI trial. Ann Emerg Med. 2009;54(6):779-788.

Miller CD, Hwang W, Case D, Lefebvre C, Hiestand B, Diercks DB, Hamilton CA, Harper EN, Hoekstra JW, Hundley WG. Stress cardiac MRI in an observation unit setting reduces index hospitalization cost in ED patients with chest pain at intermediate risk for acute coronary syndromes [abstract]. Circulation. 2009;120(18 Suppl 2):S337.

McMullan J, Gallaher J, Askew K, Zhang Z-M, Hoekstra J, Miller C. The association between frontal plane QRS/T angle and short-term adverse events in ED patients with chest pain [abstract]. Acad Emerg Med. 2009;16(4 Suppl 1):S116.

Miller CD, Hwang W, Hoekstra JW, Lefebvre C, Case D, Hundley WG. Randomized comparison of observation unit plus stress cardiac MRI and hospital admission [abstract]. J Cardiovasc Magn Reson. 2009;11(Suppl 1):0103.

Diercks D, Hoekstra J, Fermann G, O'Neil B, Amsterdam E, Lefebvre C, Kirk D, Krucoff M. The value of T-wave inversion in the diagnosis of an acute coronary syndrome [abstract]. Acad Emerg Med. 2009;16(4 Suppl 1):S115.

Mehta S, Hoekstra J, Myers JB, Nader R, Rokos I, Unger B, May ML. LUMEN 2009 workshops highlight pertinent issues in STEMI interventions [news magazine article]. Cath Lab Digest. 2009;17(2):.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Emergency Medicine

Clinical Interests

Cardiovascular Emergencies, Chest Pain, Emergency Medicine
James W. Hoekstra, M.D.

James W. Hoekstra, M.D.

Professor, Emergency Medicine

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