James Hill Holmes IV, M.D.Wake Forest School of Medicine

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James Hill Holmes IV, M.D.

Associate Professor,

Clinical Interests

Burns, Trauma and Surgical Critical Care, Emergency General Surgery

Contact Information

New Patient Appointments: 336-716-WAKE
Returning Patient Appointments: 336-716-3813
Department: 336-716-7021


Insurance Accepted »

Education & Training

  • B.A., Southern Methodist University, 1990
  • M.D., U Texas Sthwstn Med Sch-Dallas, 1996
  • Internship, Virginia Mason Medical Center, 1997
  • Residency, Virginia Mason Medical Center, 1998
  • Fellowship, Virginia Mason Rsrch Ctr, 1999
  • Residency, Virginia Mason Medical Center, 2002
  • Fellowship, University of Washington Schoo, 2003
  • Fellowship, University of Pennsylvania Sch, 2004

Board Certifications

  • American Board of Surgery, Surgery
  • American Board of Surgery, Surgical Critical Care


  • Int'l Soc of Burn Injuries
  • North Carolina Medical Society
  • Southern Medical Association
  • Texas Medical Assn
  • Am Burn Assn
  • Am Coll Of Surgeons
  • Assn Of Academic Surgery
  • Eastern Assn For The Surgery O
  • Golden Key National Honor Soc

NPI Number

  • 1831177138
James Hill Holmes IV, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

James Hill Holmes IV, M.D.

Associate Professor, Trauma Surgery
Institute for Regenerative Medicine

Research Interests

biotechnology, epidemiology, health services, research/outc, nutrition, surgery/trauma/burns/trauma

Contact Information

Academic: 336-716-7021 | Department: 336-716-7021


Recent Publications

Ur R, Holmes JH IV, Johnson JE, Molnar JA, Carter JE. Development of a burn escharotomy assessment tool: a pilot study. J Burn Care Res. 2016;37(2):e140-e144.

Kahn SA, Held JM, Hollowed KA, Woods J, Holmes JH IV. 'It Happened in Seconds' Firefighter Burn Prevention Program: evaluation of a 'Train the Trainer' course. J Burn Care Res. 2016;37(1):e33-e36.

Kadri SS, Miller AC, Hohmann S, Bonne S, Nielsen C, Wells C, Gruver C, Quraishi SA, Sun J, Cai R, Morris PE, Freeman BD, Holmes JH, Cairns BA, Suffredini AF. Risk factors for in-hospital mortality in smoke inhalation-associated acute lung injury: data from 68 United States hospitals. Chest. 2016;():.

Kearns RD, Ortiz-Pujols SM, Craig CK, Gusler JR, Skarote MB, Carter J, Rezak-Alger A, Cairns CB, Lofald D, Holmes JH IV, Cairns BA, Gamelli R. Advanced burn life support for day-to-day burn injury management and disaster preparedness: stakeholder experiences and student perceptions following 56 advanced burn life support courses. J Burn Care Res. 2015;36(4):455-464.

Orrey DC, Halawa OI, Bortsov AV, Shupp JW, Jones SW, Haith LR, Hoskins JM, Jordan MH, Bangdiwala SI, Roane BR, Platts-Mills TF, Holmes JH, Hwang J, Cairns BA, McLean SA. Results of a pilot multicenter genotype-based randomized placebo-controlled trial of propranolol to reduce pain after major thermal burn injury. Clin J Pain. 2015;31(1):21-29.

Kearns RD, Conlon KM, Valenta AL, Lord GC, Cairns CB, Holmes JH IV, Johnson DD, Matherly AF, Sawyer D, Skarote MB, Siler SM, Helminiak RC, Cairns BA. Disaster planning: the basics of creating a burn mass casualty disaster plan for a burn center. J Burn Care Res. 2014;35(1):E1-E13.

Kearns RD, Cairns BA, Hickerson WL, Holmes JH IV. ABA Southern Region Burn disaster plan: the process of creating and experience with the ABA Southern Region Burn Disaster Plan. J Burn Care Res. 2014;35(1):E43-E48.

Kearns RD, Holmes JH IV, Alson RL, Cairns BA. Disaster planning: the past, present, and future concepts and principles of managing a surge of burn injured patients for those involved in hospital facility planning and preparedness. J Burn Care Res. 2014;35(1):E33-E42.

Kearns RD, Hubble MW, Holmes JH IV, Cairns BA. Disaster planning: transportation resources and considerations for managing a burn disaster. J Burn Care Res. 2014;35(1):E21-E32.

Miller PR, Chang MC, Hoth JJ, Mowery NT, Hildreth AN, Martin RS, Holmes JH, Meredith JW, Requarth JA. Prospective trial of angiography and embolization for all grade III to V blunt splenic injuries: nonoperative management success rate is significantly improved. J Am Coll Surg. 2014;218(4):644-648.

Kearns RD, Holmes JH IV, Skarote MB, Cairns CB, Strickland SC, Smith HG, Cairns BA. Disasters; the 2010 Haitian earthquake and the evacuation of burn victims to US burn centers. Burns. 2014;40(6):1121-1132.

Harrington D, Holmes J, Conlon K, Jeng J. An update on the regional organizations of the American Burn Association. J Burn Care Res. 2014;35(3):228-232.

Kearns RD, Myers B, Cairns CB, Rich PB, Hultman CS, Charles AG, Jones SW, Schmits GL, Skarote MB, Holmes JH IV, Cairns BA. Hospital bioterrorism planning and burn surge. Biosecur Bioterror. 2014;12(1):20-28.

Kearns RD, Cairns CB, Holmes JH IV, Rich PB, Cairns BA. Chemical burn care: a review of best practices [magazine article]. EMS World. 2014;43(5):40-45.

Doud AN, Swanson JM, Ladd MR, Neff LP, Carter JE, Holmes JH. Referral patterns in pediatric burn patients. Am Surg. 2014;80(9):836-840.

Hughes RT, Lucas JT, Divers J, Holmes J, Krane S, Hemal AK, Frizzell BA. Predictors of locoregional and intravesical recurrence among patients treated with nephroureterectomy for urothelial tract carcinoma [abstract]. Int J Radiat Oncol Biol Phys. 2014;90(Suppl 1):S466.

Kearns RD, Skarote MB, Peterson J, Stringer L, Alson RL, Cairns BA, Hubble MW, Rich PB, Cairns CB, Holmes JH, Runge J, Siler SM, Winslow J. Deployable, portable, and temporary hospitals; one state's experiences through the years. Am J Disaster Med. 2014;9(3):195-210.

Kearns R, Holmes J IV, Cairns B. Burn disaster preparedness and the southern region of the United States. South Med J. 2013;106(1):69-73.

Kearns RD, Cairns CB, Holmes JH IV, Rich PB, Cairns BA. Thermal burn care: a review of best practices. What should prehospital providers do for these patients?. EMS World. 2013;42(1):43-51.

Holmes JH IV. Burns/inhalation injury In: Peitzman AB, Schwab CW, Yealy DM, Rhodes M, Fabian TC, eds. The trauma manual: trauma and acute care surgery. 4th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins;2013: 443-455.

Kagan RJ, Peck MD, Ahrenholz DH, Hickerson WL, Holmes J IV, Korentager R, Kraatz J, Pollock K, Kotoski G. Surgical management of the burn wound and use of skin substitutes: an expert panel white paper. J Burn Care Res. 2013;34(2):E60-E79.

Dylewski M, Wibbenmeyer L, Bessey PQ, Carter J, Gamelli R, Goodwin C, Graves T, Hollowed K, Holmes JH, Noordenbas J, Nordlund M, Savetamal A, Simpson P, Traber D, Traber L. Nutrition outcomes. J Burn Care Res. 2013;34(4):371-375.

Kearns RD, Holmes JH IV, Cairns BA. Burn injury: what's in a name? Labels used for burn injury classification: a review of the data from 2000-2012. Ann Burns Fire Disasters. 2013;26(3):115-120.

Holmes JH IV, Dimick AR. American Burn Association Southern Burn Region--recently revised [letter]. J Burn Care Res. 2012;33(2):e94.

Orlando G, Wood KJ, De Coppi P, Baptista PM, Binder KW, Bitar KN, Breuer C, Burnett L, Christ G, Farney A, Figliuzzi M, Holmes JH IV, Koch K, Macchiarini P, Mirmalek Sani S-H, Opara E, Remuzzi A, Rogers J, Saul JM, Seliktar D,. Regenerative medicine as applied to general surgery. Ann Surg. 2012;255(5):867-880.

Orrey D, Bortsov A, Liberzon I, Shupp JW, Jones S, Hwang J, Jordan M, Holmes J, Haith L, Cairns B, McLean SA. Failure of propranolol to decrease anxiety and PTSD symptoms in a genotype-based RCT of patients with major thermal burn injury [abstract]. Biol Psychiatry. 2012;71(8 Suppl):56S.

Orrey D, Bortsov A, Shupp J, Jones S, Hwang J, Jordan M, Holmes J, Haith L, Cairns B, Liberzon I, McLean S. Individuals with elevated PTSD symptoms experience increased itch symptom morbidity after major burn injury [abstract]. Biol Psychiatry. 2012;71(8 Suppl):242S-243S.

Orrey DC, Bortsov AV, Hoskins JM, Shupp JW, Jones SW, Cicuto BJ, Hwang J, Jordan MH, Holmes JH, Haith LR, Roane BM, Diatchenko L, Cairns BA, McLean SA. Catechol-O-methyltransferase genotype predicts pain severity in hospitalized burn patients. J Burn Care Res. 2012;33(4):518-523.

Holmes JH IV, Carter JE, Neff LP, Cairns BA, d'Agostino RB Jr, Griffin LP, Meredith JW. The effectiveness of regionalized burn care: an analysis of 6,873 burn admissions in North Carolina from 2000 to 2007. J Am Coll Surg. 2011;212(4):487-495.

Mowery NT, Dougherty SD, Hildreth AN, Holmes JH IV, Chang MC, Martin RS, Hoth JJ, Meredith JW, Miller PR. Emergency department length of stay is an independent predictor of hospital mortality in trauma activation patients. J Trauma. 2011;70(6):1317-1325.

Carter JE, Neff LP, Holmes JH IV. Adherence to burn center referral criteria: are patients appropriately being referred?. J Burn Care Res. 2010;31(1):26-30.

Pendleton RA, Holmes JH IV. Systemic absorption of amphotericin B with topical 5% mafenide acetate/amphotericin B solution for grafted burn wounds: is it clinically relevant?. Burns. 2010;36(1):38-41.

Neff LP, Allman JM, Holmes JH. The use of theraputic plasma exchange (TPE) in the setting of refractory burn shock. Burns. 2010;36(3):372-378.

Peck MD, Pressman MA, Caruso DM, Edelman LS, Holmes JH IV, Hughes WB, Korentager RA, Saffle JR, Voigt DW. Reimbursement for out-of-state burn patients is not always lower than that for in-state patients at regional burn centers. J Burn Care Res. 2010;31(4):603-609.

Holmes JH IV. Nutrition and venous access In: Gracias VH, McKenney MG, Reilly PM, Velmahos GC, eds. Acute care surgery: a guide for general surgeons. New York: McGraw-Hill Medical;2009: 257-262.

Holmes JH IV. Critical issues in burn care. J Burn Care Res. 2008;29(6 Suppl 2):S180-S187.

Holmes JH IV. Critical issues in burn care. South Med J. 2008;101(12 Suppl):S6-S12.

Pendleton RA, Holmes JH IV. Systemic absorption of amphotericin B with topical 5% mafenide acetate/amphotericin B solution for grafted burn wounds: is it clinically relevant? [abstract]. South Med J. 2008;101(12 Suppl):S37.

Mattix KD, Tataria M, Holmes J, Kristoffersen K, Brown R, Groner J, Sciafe E, Mooney D, Nance M, Scherer L. Pediatric pancreatic trauma: predictors of nonoperative management failure and associated outcomes. J Pediatr Surg. 2007;42(2):340-344.

Tataria M, Nance ML, Holmes JH IV, Miller CC III, Mattix KD, Brown RL, Mooney DP, Scherer LRT III, Groner JI, Scaife ER, et al. Pediatric blunt abdominal injury: age is irrelevant and delayed operation is not detrimental. J Trauma. 2007;63(3):608-614.

Greenhalgh DG, Saffle JR, Holmes JH IV, Gamelli RL, Palmieri TL, Horton JW, Tompkins RG, Traber DL, Mozingo DW, Deitch EA, et al. American Burn Association Consensus Conference to define sepsis and infection in burns. J Burn Care Res. 2007;28(6):776-790.

Loveall CF, Manuel AL, Stansberry RD, Williams JH, Molnar JA, Holmes JH IV. White phosphorus and its ability to cause serious burns [abstract]. South Med J. 2007;100(12 Suppl):S16.

Nance ML, Holmes JH IV, Wiebe DJ. Timeline to operative intervention for solid organ injuries in children. J Trauma. 2006;61(6):1389-1392.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Trauma Surgery

Clinical Interests

Burns, Trauma and Surgical Critical Care, Emergency General Surgery
James Hill Holmes IV, M.D.

James Hill Holmes IV, M.D.

Associate Professor, Trauma Surgery
Institute for Regenerative Medicine

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