James Jason Hoth, M.D.
critical/intensive care medici, drugs/therapeutic agents pharm, immunology/allergy/inflammatio, metabolism, molecular biology/molecular me, prevention, surgery/trauma/burns/trauma
Academic: 336-716-0549 | Department: 336-716-0549
Vachharajani VT, Liu T, Wang X, Hoth JJ, Yoza BK, McCall CE. Sirtuins link inflammation and metabolism. J Immunol Res. 2016;2016():8167273.
Smith LM, Wells JD, Vachharajani VT, Yoza BK, McCall CE, Hoth JJ. SIRT1 mediates a primed response to immune challenge after traumatic lung injury. J Trauma Acute Care Surg. 2015;78(5):1034-1038.
Lopez JM Jr, McGonagill PW, Gross JL, Hoth JJ, Chang MC, Parker K, Requarth JA, Miller PR. Subcapsular hematoma in blunt splenic injury: a significant predictor of failure of nonoperative management. J Trauma Acute Care Surg. 2015;79(6):957-960.
Hoth JJ, Wells JD, Jones SE, Yoza BK, McCall CE. Complement mediates a primed inflammatory response after traumatic lung injury. J Trauma Acute Care Surg. 2014;76(3):601-609.
Miller PR, Chang MC, Hoth JJ, Mowery NT, Hildreth AN, Martin RS, Holmes JH, Meredith JW, Requarth JA. Prospective trial of angiography and embolization for all grade III to V blunt splenic injuries: nonoperative management success rate is significantly improved. J Am Coll Surg. 2014;218(4):644-648.
Kor DJ, Lingineni RK, Gajic O, Park PK, Blum JM, Hou PC, Hoth JJ, Anderson HL III, Bajwa EK, Bartz RR, Adesanya A, Festic E, Gong MN, Carter RE, Talmor DS. Predicting risk of postoperative lung injury in high-risk surgical patients: a multicenter cohort study. Anesthesiology. 2014;120(5):1168-1181.
Weaver AA, Danelson KA, Armstrong EG, Hoth JJ, Stitzel JD. Investigation of pulmonary contusion extent and its correlation to crash, occupant, and injury characteristics in motor vehicle crashes. Accid Anal Prev. 2013;50():223-233.
Hoth JJ. A grim picture, indeed [editorial]. Crit Care Med. 2013;41(3):923-324.
Festic E, Ortiz-Diaz E, Lee A, Li G, Kor DJ, Adebola A, Akca O, Hoth J, Levitt JE, Carter R, Gajic O. Prehospital use of inhaled steroids and incidence of acute lung injury among patients at risk. J Crit Care. 2013;28(6):985-991.
Karnatovskaia LV, Lee AS, Gajic O, Festic E, Hoth JJ,Uddin D. The influence of prehospital systemic corticosteroid use on development of acute respiratory distress syndrome and hospital outcomes. Crit Care Med. 2013;41(7):1679-1685.
Brzoza-Lewis KL, Hoth JJ, Hiltbold EM. Type I interferon signaling regulates the composition of inflammatory infiltrates upon infection with Listeria monocytogenes. Cell Immunol. 2012;273(1):41-51.
Hoth JJ, Wells JD, Yoza BK, McCall CE. Innate immune response to pulmonary contusion: identification of cell type-specific inflammatory responses. Shock. 2012;37(4):385-391.
Becher RD, Meredith JW, Chang MC, Hoth JJ, Beard HR, Miller PR. Creation and implementation of an emergency general surgery registry modeled after the National Trauma Data Bank. J Am Coll Surg. 2012;214(2):156-163.
Meredith JW, Hoth JJ. Thoracic trauma In: Fischer JE, Jones DB, Pomposelli FB, Upchurch GR, Klimberg VS, Schwaitzberg SD, Bland KI, eds. Fischer's mastery of surgery, vol 1. 6th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins;2012: 675-687.
Becher RD, Hoth JJ, Miller PR, Meredith JW, Chang MC. Systemic inflammation worsens outcomes in emergency surgical patients. J Trauma Acute Care Surg. 2012;72(5):1140-1149.
Becher RD, Chang MC, Hoth JJ, Kendall JL, Beard HR, Miller PR. Does acute physiology and chronic health evaluation II provide a valid metric to directly compare disease severity in trauma versus surgical intensive care unit patients?. Am Surg. 2012;78(11):1261-1269.
Becher RD, Colonna AL, Enniss TM, Weaver AA, Crane DK, Martin RS, Mowery NT, Miller PR, Stitzel JD, Hoth JJ. An innovative approach to predict the development of adult respiratory distress syndrome in patients with blunt trauma. J Trauma Acute Care Surg. 2012;73(5):1229-1235.
Becher RD, Hoth JJ, Rebo JJ, Kendall JL, Miller PR. Locally derived versus guideline-based approach to treatment of hospital-acquired pneumonia in the trauma intensive care unit. Surg Infect (Larchmt). 2012;13(6):352-359.
Gajic O, Dabbagh O, Park PK, Adesanya A, Chang SY, Hou P, Anderson H III, Hoth JJ, Mikkelsen ME, Gentile NT, et al. Early identification of patients at risk of acute lung injury: evaluation of lung injury prediction score in a multicenter cohort study. Am J Respir Crit Care Med. 2011;183(4):462-470.
Hoth JJ, Wells JD, Hiltbold EM, McCall CE, Yoza BK. Mechanism of neutrophil recruitment to the lung after pulmonary contusion. Shock. 2011;35(6):604-609.
Mowery NT, Dougherty SD, Hildreth AN, Holmes JH IV, Chang MC, Martin RS, Hoth JJ, Meredith JW, Miller PR. Emergency department length of stay is an independent predictor of hospital mortality in trauma activation patients. J Trauma. 2011;70(6):1317-1325.
Becher RD, Hoth JJ, Miller PR, Mowery NT, Chang MC, Meredith JW. A critical assessment of outcomes in emergency versus nonemergency general surgery using the American College of Surgeons National Surgical Quality Improvement Program database. Am Surg. 2011;77(7):951-959.
Gayzik FS, Hoth JJ, Stitzel JD. Finite element-based injury metrics for pulmonary contusion via concurrent model optimization. Biomech Model Mechanobiol. 2011;10(4):505-520.
Becher RD, Hoth JJ, Neff LP, Rebo JJ, Martin RS, Miller PR. Multidrug-resistant pathogens and pneumonia: comparing the trauma and surgical intensive care units. Surg Infect (Larchmt). 2011;12(4):267-272.
Danelson KA, Gayzik FS, Stern AR, Hoth JJ, Stitzel JD. Design, development, and analysis of a surrogate for pulmonary injury prediction. Ann Biomed Eng. 2011;39(10):2560-2567.
Hildreth AN, Enniss T, Martin RS, Miller PR, Mitten-Long D, Gasaway J, Chang MC, Hoth JJ, Mowery NT, Meredith JW, et al. Surgical intensive care unit mobility is increased after institution of a computerized mobility order set and intensive care unit mobility protocol: a prospective cohort analysis. Am Surg. 2010;76(8):818-822.
Hoth JJ, Yoza BK, Wells JD, Meredith JW, McCall CE. Pulmonary parenchymal cells mediate toll-like receptor dependent responses after traumatic lung injury. J Am Coll Surg. 2010;211(3 Suppl):S51.
Gayzik FS, Martin RS, Gabler HC, Hoth JJ, Duma SM, Meredith JW, Stitzel JD. Characterization of crash-induced thoracic loading resulting in pulmonary contusion. J Trauma. 2009;66(3):840-849.
Hoth JJ, Wells JD, Brownlee NA, Hiltbold EM, Meredith JW, McCall CE, Yoza BK. Toll-like receptor 4-dependent responses to lung injury in a murine model of pulmonary contusion. Shock. 2009;31(4):376-381.
Hoth JJ, Martin RS, Yoza BK, Wells JD, Meredith JW, McCall CE. Pulmonary contusion primes systemic innate immunity responses. J Trauma. 2009;67(1):14-21.
Daly M, Miller PR, Carr JJ, Gayzik FS, Hoth JJ, Meredith JW, Stitzel JD. Traumatic pulmonary pathology measured with computed tomography and a semiautomated analytic method. Clin Imaging. 2008;32(5):346-354.
Gayzik FS, Hoth JJ, Stitzel JD. Quantitative histology of contused lung tissue with comparison to computed tomography. Biomed Sci Instrum. 2008;44():225-230.
Meredith JW, Hoth JJ. Thoracic trauma: when and how to intervene. Surg Clin North Am. 2007;87(1):95-118.
Danelson KA, Hoth JJ, Miller PR, Stitzel JD. A semi-automated approach for measuring splenic injury using computed tomography. Biomed Sci Instrum. 2007;43():13-17.
Gayzik FS, Hoth JJ, Stitzel JD. A comparative study of optimization techniques for tuning a finite element model of the lung to biomechanical data. Biomed Sci Instrum. 2007;43():212-217.
Martin RS, Smith JS, Hoth JJ, Miller PR, Meredith JW, Chang MC. Increased insulin requirements are associated with pneumonia after severe injury. J Trauma. 2007;63(2):358-364.
Hoth JJ, Hudson WP, Brownlee NA, Yoza BK, Hiltbold EM, Meredith JW, McCall CE. Toll-like receptor 2 participates in the response to lung injury in a murine model of pulmonary contusion. Shock. 2007;28(4):447-452.
Turina M, Hoth JJ, Turpen RM, Scott MJ, Cheadle WG. Alveolar interleukin-10 regulates neutrophil apoptosis in severely traumatized patients. J Trauma. 2007;63(4):733-739.
Gayzik FS, Hoth JJ, Daly M, Meredith JW, Stitzel JD. A finite element-based injury metric for pulmonary contusion: investigation of candidate metrics through correlation with computed tomography. Stapp Car Crash J. 2007;51():189-209.
Hoth JJ, Stitzel JD, Gayzik FS, Brownlee NA, Miller PR, Yoza BK, McCall CE, Meredith JW, Payne RM. The pathogenesis of pulmonary contusion: an open chest model in the rat. J Trauma. 2006;61(1):32-45.
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