James Jason Hoth, M.D.
Professor, General Surgery
Lung Injury; Neutrophil Infiltration; Thoracic Injuries; Lung; Wounds, Nonpenetrating
Academic: 336-716-0827 | Department: 336-716-0827
Sirtuins link inflammation and metabolism. Vachharajani VT, Liu T, Wang X, Hoth JJ, Yoza BK, McCall CE.. J Immunol Res. 2016;2016():8167273.
Pulmonary contusion decreases SIRT1 and primes the lung for a second hit [abstract]. Hoth JJ, Furdui CM, Wells JD, Yoza B, McCall C.. Shock. 2016;45(6 Suppl 1):85.
SIRT1 mediates a primed response to immune challenge after traumatic lung injury. Smith LM, Wells JD, Vachharajani VT, Yoza BK, McCall CE, Hoth JJ.. J Trauma Acute Care Surg. 2015;78(5):1034-1038.
Subcapsular hematoma in blunt splenic injury: a significant predictor of failure of nonoperative management. Lopez JM Jr, McGonagill PW, Gross JL, Hoth JJ, Chang MC, Parker K, Requarth JA, Miller PR.. J Trauma Acute Care Surg. 2015;79(6):957-960.
Complement mediates a primed inflammatory response after traumatic lung injury. Hoth JJ, Wells JD, Jones SE, Yoza BK, McCall CE.. J Trauma Acute Care Surg. 2014;76(3):601-609.
Prospective trial of angiography and embolization for all grade III to V blunt splenic injuries: nonoperative management success rate is significantly improved. Miller PR, Chang MC, Hoth JJ, Mowery NT, Hildreth AN, Martin RS, Holmes JH, Meredith JW, Requarth JA.. J Am Coll Surg. 2014;218(4):644-648.
Predicting risk of postoperative lung injury in high-risk surgical patients: a multicenter cohort study. Kor DJ, Lingineni RK, Gajic O, Park PK, Blum JM, Hou PC, Hoth JJ, Anderson HL III, Bajwa EK, Bartz RR, Adesanya A, Festic E, Gong MN, Carter RE, Talmor DS.. Anesthesiology. 2014;120(5):1168-1181.
Investigation of pulmonary contusion extent and its correlation to crash, occupant, and injury characteristics in motor vehicle crashes. Weaver AA, Danelson KA, Armstrong EG, Hoth JJ, Stitzel JD.. Accid Anal Prev. 2013;50():223-233.
A grim picture, indeed [editorial]. Hoth JJ.. Crit Care Med. 2013;41(3):923-324.
Prehospital use of inhaled steroids and incidence of acute lung injury among patients at risk. Festic E, Ortiz-Diaz E, Lee A, Li G, Kor DJ, Adebola A, Akca O, Hoth J, Levitt JE, Carter R, Gajic O.. J Crit Care. 2013;28(6):985-991.
The influence of prehospital systemic corticosteroid use on development of acute respiratory distress syndrome and hospital outcomes. Karnatovskaia LV, Lee AS, Gajic O, Festic E, Hoth JJ,Uddin D.. Crit Care Med. 2013;41(7):1679-1685.
Type I interferon signaling regulates the composition of inflammatory infiltrates upon infection with Listeria monocytogenes. Brzoza-Lewis KL, Hoth JJ, Hiltbold EM.. Cell Immunol. 2012;273(1):41-51.
Innate immune response to pulmonary contusion: identification of cell type-specific inflammatory responses. Hoth JJ, Wells JD, Yoza BK, McCall CE.. Shock. 2012;37(4):385-391.
Creation and implementation of an emergency general surgery registry modeled after the National Trauma Data Bank. Becher RD, Meredith JW, Chang MC, Hoth JJ, Beard HR, Miller PR.. J Am Coll Surg. 2012;214(2):156-163.
Thoracic trauma. Meredith JW, Hoth JJ. In: Fischer JE, Jones DB, Pomposelli FB, Upchurch GR, Klimberg VS, Schwaitzberg SD, Bland KI, eds. Fischer's mastery of surgery, vol 1. 6th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins;2012: 675-687.
Systemic inflammation worsens outcomes in emergency surgical patients. Becher RD, Hoth JJ, Miller PR, Meredith JW, Chang MC.. J Trauma Acute Care Surg. 2012;72(5):1140-1149.
Does acute physiology and chronic health evaluation II provide a valid metric to directly compare disease severity in trauma versus surgical intensive care unit patients?. Becher RD, Chang MC, Hoth JJ, Kendall JL, Beard HR, Miller PR.. Am Surg. 2012;78(11):1261-1269.
An innovative approach to predict the development of adult respiratory distress syndrome in patients with blunt trauma. Becher RD, Colonna AL, Enniss TM, Weaver AA, Crane DK, Martin RS, Mowery NT, Miller PR, Stitzel JD, Hoth JJ.. J Trauma Acute Care Surg. 2012;73(5):1229-1235.
Locally derived versus guideline-based approach to treatment of hospital-acquired pneumonia in the trauma intensive care unit. Becher RD, Hoth JJ, Rebo JJ, Kendall JL, Miller PR.. Surg Infect (Larchmt). 2012;13(6):352-359.
Early identification of patients at risk of acute lung injury: evaluation of lung injury prediction score in a multicenter cohort study. Gajic O, Dabbagh O, Park PK, Adesanya A, Chang SY, Hou P, Anderson H III, Hoth JJ, Mikkelsen ME, Gentile NT, et al.. Am J Respir Crit Care Med. 2011;183(4):462-470.
Mechanism of neutrophil recruitment to the lung after pulmonary contusion. Hoth JJ, Wells JD, Hiltbold EM, McCall CE, Yoza BK.. Shock. 2011;35(6):604-609.
Emergency department length of stay is an independent predictor of hospital mortality in trauma activation patients. Mowery NT, Dougherty SD, Hildreth AN, Holmes JH IV, Chang MC, Martin RS, Hoth JJ, Meredith JW, Miller PR.. J Trauma. 2011;70(6):1317-1325.
A critical assessment of outcomes in emergency versus nonemergency general surgery using the American College of Surgeons National Surgical Quality Improvement Program database. Becher RD, Hoth JJ, Miller PR, Mowery NT, Chang MC, Meredith JW.. Am Surg. 2011;77(7):951-959.
Finite element-based injury metrics for pulmonary contusion via concurrent model optimization. Gayzik FS, Hoth JJ, Stitzel JD.. Biomech Model Mechanobiol. 2011;10(4):505-520.
Multidrug-resistant pathogens and pneumonia: comparing the trauma and surgical intensive care units. Becher RD, Hoth JJ, Neff LP, Rebo JJ, Martin RS, Miller PR.. Surg Infect (Larchmt). 2011;12(4):267-272.
Design, development, and analysis of a surrogate for pulmonary injury prediction. Danelson KA, Gayzik FS, Stern AR, Hoth JJ, Stitzel JD.. Ann Biomed Eng. 2011;39(10):2560-2567.
Surgical intensive care unit mobility is increased after institution of a computerized mobility order set and intensive care unit mobility protocol: a prospective cohort analysis. Hildreth AN, Enniss T, Martin RS, Miller PR, Mitten-Long D, Gasaway J, Chang MC, Hoth JJ, Mowery NT, Meredith JW, et al.. Am Surg. 2010;76(8):818-822.
Pulmonary parenchymal cells mediate toll-like receptor dependent responses after traumatic lung injury. Hoth JJ, Yoza BK, Wells JD, Meredith JW, McCall CE.. J Am Coll Surg. 2010;211(3 Suppl):S51.
Characterization of crash-induced thoracic loading resulting in pulmonary contusion. Gayzik FS, Martin RS, Gabler HC, Hoth JJ, Duma SM, Meredith JW, Stitzel JD.. J Trauma. 2009;66(3):840-849.
Toll-like receptor 4-dependent responses to lung injury in a murine model of pulmonary contusion. Hoth JJ, Wells JD, Brownlee NA, Hiltbold EM, Meredith JW, McCall CE, Yoza BK.. Shock. 2009;31(4):376-381.
Pulmonary contusion primes systemic innate immunity responses. Hoth JJ, Martin RS, Yoza BK, Wells JD, Meredith JW, McCall CE.. J Trauma. 2009;67(1):14-21.
Traumatic pulmonary pathology measured with computed tomography and a semiautomated analytic method. Daly M, Miller PR, Carr JJ, Gayzik FS, Hoth JJ, Meredith JW, Stitzel JD.. Clin Imaging. 2008;32(5):346-354.
Quantitative histology of contused lung tissue with comparison to computed tomography. Gayzik FS, Hoth JJ, Stitzel JD.. Biomed Sci Instrum. 2008;44():225-230.
Thoracic trauma: when and how to intervene. Meredith JW, Hoth JJ.. Surg Clin North Am. 2007;87(1):95-118.
A semi-automated approach for measuring splenic injury using computed tomography. Danelson KA, Hoth JJ, Miller PR, Stitzel JD.. Biomed Sci Instrum. 2007;43():13-17.
A comparative study of optimization techniques for tuning a finite element model of the lung to biomechanical data. Gayzik FS, Hoth JJ, Stitzel JD.. Biomed Sci Instrum. 2007;43():212-217.
Increased insulin requirements are associated with pneumonia after severe injury. Martin RS, Smith JS, Hoth JJ, Miller PR, Meredith JW, Chang MC.. J Trauma. 2007;63(2):358-364.
Toll-like receptor 2 participates in the response to lung injury in a murine model of pulmonary contusion. Hoth JJ, Hudson WP, Brownlee NA, Yoza BK, Hiltbold EM, Meredith JW, McCall CE.. Shock. 2007;28(4):447-452.
Alveolar interleukin-10 regulates neutrophil apoptosis in severely traumatized patients. Turina M, Hoth JJ, Turpen RM, Scott MJ, Cheadle WG.. J Trauma. 2007;63(4):733-739.
A finite element-based injury metric for pulmonary contusion: investigation of candidate metrics through correlation with computed tomography. Gayzik FS, Hoth JJ, Daly M, Meredith JW, Stitzel JD.. Stapp Car Crash J. 2007;51():189-209.
The pathogenesis of pulmonary contusion: an open chest model in the rat. Hoth JJ, Stitzel JD, Gayzik FS, Brownlee NA, Miller PR, Yoza BK, McCall CE, Meredith JW, Payne RM.. J Trauma. 2006;61(1):32-45.
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