Denise Kathryn Houston, Ph.D.Wake Forest School of Medicine

Denise Kathryn Houston, Ph.D.

Associate Professor,

Contact Information

Academic: 336-713-8558 | Department: 336-713-8570


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Education & Training

  • B.S., University of Georgia, 1993
  • M.S., University of Georgia, 1998
  • Ph.D., University of North Carolina-Chapel Hill, 2004


  • Obesity Society
  • Am Dietetic Assn
  • Am Soc for Nutrition
  • Gerontological Society Of Amer
Denise Kathryn Houston, Ph.D.

Denise Kathryn Houston, Ph.D.

Associate Professor, Gerontology and Geriatric Medicine
Center on Diabetes, Obesity, and Metabolism

Research Interests

Vitamin D; Obesity; Vitamin D Deficiency; Body Composition; Aging
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Contact Information

Academic: 336-713-8558 | Department: 336-713-8570


Media Medical Expert »

Recent Publications

Effects of longitudinal glucose exposure on cognitive and physical function: results from the Action for Health in Diabetes Movement and Memory study. Beavers KM, Leng I, Rapp SR, Miller ME, Houston DK, Marsh AP, Hire DG, Baker LD, Bray GA, Blackburn GL, Hergenroeder AL, Jakicic JM, Johnson KC, Korytkowski MT, Dorsten BV, Kritchevsky SB.. J Am Geriatr Soc. 2017;65(1):137-145.

Apolipoprotein E allele and hearing thresholds in older adults. Mener DJ, Betz J, Yaffe K, Harris TB, Helzner EP, Satterfield S, Houston DK, Strotmeyer ES, Pratt SR, Simonsick EM, Lin FR.. Am J Alzheimers Dis Other Demen. 2016;31(1):34-39.

Caloric restriction during aerobic training enhances cardiorespiratory fitness in obese, older adults: a randomized controlled trial: 1529 Board #182 June 2, 9: 00 AM - 10: 30 AM [abstract]. Nicklas BJ, Crotts C, Chmelo EA, Yow D, Gordon M, Lyles MF, Beavers KM, Houston DK, Hugenschmidt C, Leng I, Brinkley TE.. Med Sci Sports Exerc. 2016;48(5 Suppl 1):416-417.

The decline in physical performance and onset of sarcopenia is associated with the development of urinary incontinence in older community dwelling women [abstract]. Parker-Autry C, Houston D, Rushing J, Richter H, Subak L, Kanaya A, Kritchevsky S.. Neurourol Urodyn. 2016;35(Suppl 4):S251-S252.

Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations. Yoneyama S, Yao J, Guo X, Fernandez-Rhodes L, Lim U, Boston J, Buzkova P, Carlson CS, Cheng I, Cochran B, Cooper R, Ehret G, Fornage M, Gong J, Gross M, Gu CC, Haessler J, Haiman CA, Henderson B, Hindorff LA, Houston D, Irvin MR,.. Int J Obes (Lond). 2016;():.

Association between the Mediterranean diet and cognitive decline in a biracial population. Koyama A, Houston DK, Simonsick EM, Lee JS, Ayonayon HN, Shahar DR, Rosano C, Satterfield S, Yaffe K.. J Gerontol A Biol Sci Med Sci. 2015;70(3):352-357.

Vitamin D insufficiency and abnormal hemoglobin A1c in black and white older persons. Kositsawat J, Kuchel GA, Tooze JA, Houston DK, Cauley JA, Kritchevsky SB, Strotmeyer ES, Kanaya AM, Harris TB, Johnson KC, Barry LC.. J Gerontol A Biol Sci Med Sci. 2015;70(4):525-531.

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Cornelis MC, Byrne EM, Esko T, Nalls MA, Ganna A, Paynter N, Monda KL, Amin N, Fischer K, Renstrom F, Ngwa JS, Huikari V, Cavadino A, Nolte IM, Teumer A, Yu K, Marques-Vidal P, Rawal R, Manichaikul A, Wojczynski MK, Vink JM, Zhao JH, Burlutsky G,.. Mol Psychiatry. 2015;20(5):647-656.

A long-term intensive lifestyle intervention and physical function: The look AHEAD Movement and Memory study. Houston DK, Leng X, Bray GA, Hergenroeder AL, Hill JO, Jakicic JM, Johnson KC, Neiberg RH, Marsh AP, Rejeski WJ, Kritchevsky SB.. Obesity (Silver Spring). 2015;23(1):77-84.

Genetic and environmental factors are associated with serum 25-hydroxyvitamin D concentrations in older African Americans. Hansen JG, Tang W, Hootman KC, Brannon PM, Houston DK, Kritchevsky SB, Harris TB, Garcia M, Lohman K, Liu Y, de Boer IH, Kestenbaum BR, Robinson-Cohen C, Siscovick DS, Cassano PA.. J Nutr. 2015;145(4):799-805.

Intentional weight loss and all-cause mortality: a meta-analysis of randomized clinical trials. Kritchevsky SB, Beavers KM, Miller ME, Shea MK, Houston DK, Kitzman DW, Nicklas BJ.. PLoS One. 2015;10(3):e0121993.

The long-term effects of intentional weight loss on body composition and physical function in older adults: a pilot study [abstract]. Houston DK, Miller ME, Kitzman DW, Rejeski WJ, Messier SP, Lyles MF, Kritchevsky S, Nicklas BJ.. J Am Geriatr Soc. 2015;63(Suppl 1):S14-S15.

Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults. Zimmermann E, Angquist LH, Mirza SS, Zhao JH, Chasman DI, Fischer K, Qi Q, Smith AV, Thinggaard M, Jarczok MN, Nalls MA, Trompet S, Timpson NJ, Schmidt B, Jackson AU, Lyytikainen LP, Verweij N, Mueller-Nurasyid M, Vikstrom M, Marques-Vidal P,.. Obes Rev. 2015;16(4):327-340.

Vitamin D and age-related health outcomes: movement, mood, and memory. Houston DK.. Curr Nutr Rep. 2015;4(2):185-200.

Low 25-hydroxyvitamin D concentrations predict incident depression in well-functioning older adults: the Health, Aging, and Body Composition Study. Williams JA, Sink KM, Tooze JA, Atkinson HH, Cauley JA, Yaffe K, Tylavsky FA, Rubin SM, Simonsick EM, Kritchevsky SB, Houston DK.. J Gerontol A Biol Sci Med Sci. 2015;70(6):757-763.

Gene x dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry. Nettleton JA, Follis JL, Ngwa JS, Smith CE, Ahmad S, Tanaka T, Wojczynski MK, Voortman T, Lemaitre RN, Kristiansson K, Nuotio ML, Houston DK, Perala MM, Qi Q, Sonestedt E, Manichaikul A, Kanoni S, Ganna A, Mikkila V, North KE, Siscovick DS,.. Hum Mol Genet. 2015;24(16):4728-4738.

Protein intake and incident mobility limitations in older adults: the Health ABC Study [abstract]. Houston DK, Tooze JA, Garcia KR, Visser M, Tylavsky FA, Hue TF, Lee JS, Murphy RA, Simonsick EM, Harris TB, Newman AB, Kritchevsky SB.. J Frailty Aging. 2015;4(Suppl 1):30.

Caloric restriction for treatment of geriatric obesity: do the benefits outweigh the risks?. Normandin E, Houstin DK, Nicklas BJ.. Curr Nutr Rep. 2015;4(2):143-155.

Delivery of a vitamin D intervention in homebound older adults using a Meals-on-Wheels program: a pilot study. Houston DK, Tooze JA, Demons JL, Davis BL, Shertzer-Skinner R, Kearsley LB, Kritchevsky SB, Williamson JD.. J Am Geriatr Soc. 2015;63(9):1861-1867.

Body mass index trajectories in relation to change in lean mass and physical function: the Health, Aging and Body Composition Study. Reinders I, Murphy RA, Martin KR, Brouwer IA, Visser M, White DK, Newman AB, Houston DK, Kanaya AM, Nagin DS, Harris TB.. J Am Geriatr Soc. 2015;63(8):1615-1621.

Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians. Fretts AM, Follis JL, Nettleton JA, Lemaitre RN, Ngwa JS, Wojczynski MK, Kalafati IP, Varga TV, Frazier-Wood AC, Houston DK, Lahti J, Ericson U, van den Hooven EH, Mikkila V, Kiefte-de Jong JC, Mozaffarian D, Rice K, Renstrom F, North KE, McKeown NM,.. Am J Clin Nutr. 2015;102(5):1266-1278.

Body weight dynamics following intentional weight loss and physical performance: the Look AHEAD Movement and Memory Study. Beavers KM, Neiberg RH, Houston DK, Bray GA, Hill JO, Jakicic JM, Johnson KC, Kritchevsky SB.. Obes Sci Pract. 2015;1(1):12-22.

Long-term impact of a behavioral weight loss intervention on mobility: the Look AHEAD Study [abstract]. Houston DK, Neiberg R, Hill JO, Johnson KC, Pi-Sunyer X, Jakicic JM, Wing R, Kritchevsky SB.. Gerontologist. 2015;55(Suppl 2):338.

Dietary interventions for the treatment of geriatric obesity: do the benefits outweigh the risks? [abstract]. Nicklas B, Houston DK.. Gerontologist. 2015;55(Suppl 2):517.

Relationship between 25-hydroxyvitamin d and cognitive function in older adults: the health, aging and body composition study. Wilson VK, Houston DK, Kilpatrick L, Lovato J, Yaffe K, Cauley JA, Harris TB, Simonsick EM, Ayonayon HN, Kritchevsky SB, Sink KM.. J Am Geriatr Soc. 2014;62(4):636-641.

Vitamin D status is associated with grip strength in centenarians. Haslam A, Johnson MA, Hausman DB, Cress ME, Houston DK, Davey A, Poon LW.. J Nutr Gerontol Geriatr. 2014;33(1):35-46.

Long-term impact of behavioral weight loss intervention on cognitive function. Espeland MA, Rapp SR, Bray GA, Houston DK, Johnson KC, Kitabchi AE, Hergenroeder AL, Williamson J, Jakicic JM, van Dorsten B, Kritchevsky SB.. J Gerontol A Biol Sci Med Sci. 2014;69(9):1101-1108.

Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study. Vimaleswaran KS, Cavadino A, Berry DJ, Jorde R, Dieffenbach AK, Lu C, Alves AC, Heerspink HJ, Tikkanen E, Eriksson J, Wong A, Mangino M, Jablonski KA, Nolte IM, Houston DK, Ahluwalia TS, van der Most PJ, Pasko D, Zgaga L, Thiering E, Vitart V,.. Lancet Diabetes Endocrinol. 2014;2(9):719-729.

FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals. Qi Q, Kilpelainen TO, Downer MK, Tanaka T, Smith CE, Sluijs I, Sonestedt E, Chu AY, Renstrom F, Lin X, Angquist LH, Huang J, Liu Z, Li Y, Asif Ali M, Xu M, Ahluwalia TS, Boer JM, Chen P, Daimon M, Eriksson J, Perola M, Friedlander Y, Gao YT, Heppe DH,.. Hum Mol Genet. 2014;23(25):6961-6972.

Weight change, body composition, and risk of mobility disability and mortality in older adults: a population-based cohort study. Murphy RA, Patel KV, Kritchevsky SB, Houston DK, Newman AB, Koster A, Simonsick EM, Tylvasky FA, Cawthon PM, Harris TB.. J Am Geriatr Soc. 2014;62(8):1476-1483.

Protein intake and lower extremity physical performance in older adults: the Health ABC Study [abstract]. Houston DK, Tooze JA, Garcia KR, Visser M, Tylavsky FA, Newman AB, Harris TB, Kritchevsky SB.. J Nutr Health Aging. 2014;18(6):632.

Protein intake and lower extremity physical performance in older adults: the Health ABC Study [abstract]. Houston DK, Tooze J, Garcia KR, Visser M, Tylavsky FA, Newman AB, Harris TB, Kritchevsky SB.. Gerontologist. 2014;54(Suppl 2):460.

Predictors of physical activity and sedentary behaviors among older African American women: NHANES 2003-2006 [abstract]. Bowen P, Affuso O, Houston DK.. Gerontologist. 2014;54(Suppl 2):350.

Association of hearing impairment and incident depression in older adults [abstract]. Mener DJ, Betz J, Houston DK, Strotmeyer ES, Satterfield S, Harris T, Simonsick EM, Lin FR.. Gerontologist. 2014;54(Suppl 2):561.

Low 25-hydroxyvitamin D predicts the onset of mobility limitation and disability in community-dwelling older adults: the Health ABC Study. Houston DK, Neiberg RH, Tooze JA, Hausman DB, Johnson MA, Cauley JA, Bauer DC, Shea MK, Schwartz GG, Williamson JD, Harris TB, Kritchevsky SB.. J Gerontol A Biol Sci Med Sci. 2013;68(2):181-187.

Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts. Nettleton JA, Hivert MF, Lemaitre RN, McKeown NM, Mozaffarian D, Tanaka T, Wojczynski MK, Hruby A, Djousse L, Ngwa JS, Follis JL, Dimitriou M, Ganna A, Houston DK, Kanoni S, Mikkila V, Manichaikul A, Ntalla I, Renstrom F,.. Am J Epidemiol. 2013;177(2):103-115.

Gain-of-function lipoprotein lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site. Richardson K, Nettleton JA, Rotllan N, Tanaka T, Smith CE, Lai CQ, Parnell LD, Lee YC, Lahti J, Lemaitre RN, Manichaikul A, Keller M, Mikkila V, Ngwa J, van Rooij FJ, Ballentyne CM, Borecki IB, Cupples LA, Garcia M, Hofman A, Ferrucci L,.. Am J Hum Genet. 2013;92(1):5-14.

Associations between body composition and gait-speed decline: results from the Health, Aging, and Body Composition study. Beavers KM, Beavers DP, Houston DK, Harris TB, Hue TF, Koster A, Newman AB, Simonsick EM, Studenski SA, Nicklas BJ, Kritchevsky SB.. Am J Clin Nutr. 2013;97(3):552-560.

Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies. Hruby A, Ngwa JS, Renstrom F, Wojczynski MK, Ganna A, Hallmans G, Houston DK, Jacques PF, Kanoni S, Lehtimaki T, Lemaitre RN, Manichaikul A, North KE, Ntalla I, Sonestedt E, Tanaka T, van Rooij FJ, Bandinelli S, Djousse L, Grigoriou E,.. J Nutr. 2013;143(3):345-353.

A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) study. Peters U, North KE, Sethupathy P, Buyske S, Haessler J, Jiao S, Fesinmeyer MD, Jackson RD, Kuller LH, Rajkovic A, Lim U, Cheng I, Schumacher F, Wilkens L, Li R, Monda K, Ehret G, Nguyen KD, Cooper R, Lewis CE, Leppert M,.. PLoS Genet. 2013;9(1):e1003171.

The role of metabolic syndrome, adiposity, and inflammation in physical performance in the Health ABC Study. Beavers KM, Hsu FC, Houston DK, Beavers DP, Harris TB, Hue TF, Kim LJ, Koster A, Penninx BW, Simonsick EM, Strotmeyer ES, Kritchevsky SB, Nicklas BJ.. J Gerontol A Biol Sci Med Sci. 2013;68(5):617-623.

Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, Cooper JD, Dastani Z, Li R, Houston DK, Wood AR, Michaelsson K, Vandenput L, Zgaga L, Yerges-Armstrong LM, McCarthy MI, Dupuis J, Kaakinen M, Kleber ME, Jameson K,.. PLoS Med. 2013;10(2):e1001383.

Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake. Tanaka T, Ngwa JS, van Rooij FJ, Zillikens MC, Wojczynski MK, Frazier-Wood AC, Houston DK, Kanoni S, Lemaitre RN, Luan J, Mikkila V, Renstrom F, Sonestedt E, Zhao JH, Chu AY, Qi L, Chasman DI, de Oliveira Otto MC,.. Am J Clin Nutr. 2013;97(6):1395-1402.

Dietary and supplemental calcium intake and cardiovascular disease mortality: the National Institutes of Health-AARP diet and health study. Xiao Q, Murphy RA, Houston DK, Harris TB, Chow WH, Park Y.. JAMA Intern Med. 2013;173(8):639-646.

Lipoprotein receptor-related protein 1 variants and dietary fatty acids: meta-analysis of European origin and African American studies. Smith CE, Ngwa J, Tanaka T, Qi Q, Wojczynski MK, Lemaitre RN, Anderson JS, Manichaikul A, Mikkila V, van Rooij FJ, Ye Z, Bandinelli S, Frazier-Wood AC, Houston DK, Hu F, Langenberg C, McKeown NM, Mozaffarian D, North KE,.. Int J Obes (Lond). 2013;37(9):1211-1220.

Predictors of serum 25(OH) D in elderly African-Americans in the Health, Aging, and Body Composition (Health ABC) Study [abstract]. Hansen JG, Hootman K, Tang W, Brannon PM, Kritchevsky S, Houston D, Harris T, Garcia M, Liu Y, Lohman K, Cassano PA.. FASEB J. 2013;27():245.4.

Fine mapping and identification of BMI loci in African Americans. Gong J, Schumacher F, Lim U, Hindorff LA, Haessler J, Buyske S, Carlson CS, Rosse S, Buzkova P, Fornage M, Gross M, Pankratz N, Pankow JS, Schreiner PJ, Cooper R, Ehret G, Gu CC, Houston D, Irvin MR, Jackson R, Kuller L,.. Am J Hum Genet. 2013;93(4):661-671.

Impact of a long-term intensive lifestyle intervention on physical function: the action for health and memory study in diabetes movement [abstract]. Houston DK, Bray GA, Hill JO, Jakicic JM Johnson KC, Leng X, Rejeski W, Kritchevsky SB.. Gerontologist. 2013;53(Suppl 1):389.

Impact of a long-term behavioral weight loss intervention on cognitive function: the Action for Health in Diabetes Movement and Memory Study [abstract]. Rapp S, Bray GA, Hergenroeder AL, Houston DK, Jakicic JM, Kitabchi AE, Van Dorsten B, Williamson JD.. Gerontologist. 2013;53(Suppl 1):389.

Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function. Reardon BJ, Hansen JG, Crystal RG, Houston DK, Kritchevsky SB, Harris T, Lohman K, Liu Y, O'Connor GT, Wilk JB, Mezey J, Gao C, Cassano PA.. BMC Med Genet. 2013;14():122.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Gerontology and Geriatric Medicine

Denise Kathryn Houston, Ph.D.

Denise Kathryn Houston, Ph.D.

Associate Professor, Gerontology and Geriatric Medicine
Center on Diabetes, Obesity, and Metabolism

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