Denise Kathryn Houston, Ph.D.Wake Forest School of Medicine

Denise Kathryn Houston, Ph.D.

Associate Professor,

Contact Information

Academic: 336-713-8558 | Department: 336-713-8217

Media Medical Expert »

Education & Training

  • B.S., University of Georgia, 1993
  • M.S., University of Georgia, 1998
  • Ph.D., University of North Carolina-Chapel Hill, 2004


  • Am Dietetic Assn
  • Am Soc for Nutrition
  • Gerontological Society Of Amer
  • Obesity Society
Denise Kathryn Houston, Ph.D.

Denise Kathryn Houston, Ph.D.

Associate Professor, Gerontology and Geriatric Medicine
Sticht Center on Aging
Center on Diabetes, Obesity, and Metabolism
Epidemiology & Prevention

Research Interests

aging, epidemiology, health services, research/outc, nutrition, obesity

Contact Information

Academic: 336-713-8558 | Department: 336-713-8217

Media Medical Expert »

Recent Publications

Koyama A, Houston DK, Simonsick EM, Lee JS, Ayonayon HN, Shahar DR, Rosano C, Satterfield S, Yaffe K. Association between the Mediterranean diet and cognitive decline in a biracial population. J Gerontol A Biol Sci Med Sci. 2015;70(3):352-357.

Kositsawat J, Kuchel GA, Tooze JA, Houston DK, Cauley JA, Kritchevsky SB, Strotmeyer ES, Kanaya AM, Harris TB, Johnson KC, Barry LC. Vitamin D insufficiency and abnormal hemoglobin A1c in black and white older persons. J Gerontol A Biol Sci Med Sci. 2015;70(4):525-531.

Cornelis MC, Byrne EM, Esko T, Nalls MA, Ganna A, Paynter N, Monda KL, Amin N, Fischer K, Renstrom F, Ngwa JS, Huikari V, Cavadino A, Nolte IM, Teumer A, Yu K, Marques-Vidal P, Rawal R, Manichaikul A, Wojczynski MK, Vink JM, Zhao JH, Burlutsky G,. Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Mol Psychiatry. 2015;20(5):647-656.

Houston DK, Leng X, Bray GA, Hergenroeder AL, Hill JO, Jakicic JM, Johnson KC, Neiberg RH, Marsh AP, Rejeski WJ, Kritchevsky SB. A long-term intensive lifestyle intervention and physical function: The look AHEAD Movement and Memory study. Obesity (Silver Spring). 2015;23(1):77-84.

Hansen JG, Tang W, Hootman KC, Brannon PM, Houston DK, Kritchevsky SB, Harris TB, Garcia M, Lohman K, Liu Y, de Boer IH, Kestenbaum BR, Robinson-Cohen C, Siscovick DS, Cassano PA. Genetic and environmental factors are associated with serum 25-hydroxyvitamin D concentrations in older African Americans. J Nutr. 2015;145(4):799-805.

Kritchevsky SB, Beavers KM, Miller ME, Shea MK, Houston DK, Kitzman DW, Nicklas BJ. Intentional weight loss and all-cause mortality: a meta-analysis of randomized clinical trials. PLoS One. 2015;10(3):e0121993.

Houston DK, Miller ME, Kitzman DW, Rejeski WJ, Messier SP, Lyles MF, Kritchevsky S, Nicklas BJ. The long-term effects of intentional weight loss on body composition and physical function in older adults: a pilot study [abstract]. J Am Geriatr Soc. 2015;63(Suppl 1):S14-S15.

Zimmermann E, Angquist LH, Mirza SS, Zhao JH, Chasman DI, Fischer K, Qi Q, Smith AV, Thinggaard M, Jarczok MN, Nalls MA, Trompet S, Timpson NJ, Schmidt B, Jackson AU, Lyytikainen LP, Verweij N, Mueller-Nurasyid M, Vikstrom M, Marques-Vidal P,. Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults. Obes Rev. 2015;16(4):327-340.

Houston DK. Vitamin D and age-related health outcomes: movement, mood, and memory. Curr Nutr Rep. 2015;4(2):185-200.

Williams JA, Sink KM, Tooze JA, Atkinson HH, Cauley JA, Yaffe K, Tylavsky FA, Rubin SM, Simonsick EM, Kritchevsky SB, Houston DK. Low 25-hydroxyvitamin D concentrations predict incident depression in well-functioning older adults: the Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2015;70(6):757-763.

Nettleton JA, Follis JL, Ngwa JS, Smith CE, Ahmad S, Tanaka T, Wojczynski MK, Voortman T, Lemaitre RN, Kristiansson K, Nuotio ML, Houston DK, Perala MM, Qi Q, Sonestedt E, Manichaikul A, Kanoni S, Ganna A, Mikkila V, North KE, Siscovick DS,. Gene x dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry. Hum Mol Genet. 2015;24(16):4728-4738.

Houston DK, Tooze JA, Garcia KR, Visser M, Tylavsky FA, Hue TF, Lee JS, Murphy RA, Simonsick EM, Harris TB, Newman AB, Kritchevsky SB. Protein intake and incident mobility limitations in older adults: the Health ABC Study [abstract]. J Frailty Aging. 2015;4(Suppl 1):30.

Normandin E, Houstin DK, Nicklas BJ. Caloric restriction for treatment of geriatric obesity: do the benefits outweigh the risks?. Curr Nutr Rep. 2015;4(2):143-155.

Houston DK, Tooze JA, Demons JL, Davis BL, Shertzer-Skinner R, Kearsley LB, Kritchevsky SB, Williamson JD. Delivery of a vitamin D intervention in homebound older adults using a Meals-on-Wheels program: a pilot study. J Am Geriatr Soc. 2015;63(9):1861-1867.

Reinders I, Murphy RA, Martin KR, Brouwer IA, Visser M, White DK, Newman AB, Houston DK, Kanaya AM, Nagin DS, Harris TB. Body mass index trajectories in relation to change in lean mass and physical function: the Health, Aging and Body Composition Study. J Am Geriatr Soc. 2015;63(8):1615-1621.

Fretts AM, Follis JL, Nettleton JA, Lemaitre RN, Ngwa JS, Wojczynski MK, Kalafati IP, Varga TV, Frazier-Wood AC, Houston DK, Lahti J, Ericson U, van den Hooven EH, Mikkila V, Kiefte-de Jong JC, Mozaffarian D, Rice K, Renstrom F, North KE, McKeown NM,. Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians. Am J Clin Nutr. 2015;102(5):1266-1278.

Wilson VK, Houston DK, Kilpatrick L, Lovato J, Yaffe K, Cauley JA, Harris TB, Simonsick EM, Ayonayon HN, Kritchevsky SB, Sink KM. Relationship between 25-hydroxyvitamin d and cognitive function in older adults: the health, aging and body composition study. J Am Geriatr Soc. 2014;62(4):636-641.

Haslam A, Johnson MA, Hausman DB, Cress ME, Houston DK, Davey A, Poon LW. Vitamin D status is associated with grip strength in centenarians. J Nutr Gerontol Geriatr. 2014;33(1):35-46.

Espeland MA, Rapp SR, Bray GA, Houston DK, Johnson KC, Kitabchi AE, Hergenroeder AL, Williamson J, Jakicic JM, van Dorsten B, Kritchevsky SB. Long-term impact of behavioral weight loss intervention on cognitive function. J Gerontol A Biol Sci Med Sci. 2014;69(9):1101-1108.

Mener DJ, Betz J, Yaffe K, Harris TB, Helzner EP, Satterfield S, Houston DK, Strotmeyer ES, Pratt SR, Simonsick EM, Lin FR. Apolipoprotein E allele and hearing thresholds in older adults. Am J Alzheimers Dis Other Demen. 2014;():.

Vimaleswaran KS, Cavadino A, Berry DJ, Jorde R, Dieffenbach AK, Lu C, Alves AC, Heerspink HJ, Tikkanen E, Eriksson J, Wong A, Mangino M, Jablonski KA, Nolte IM, Houston DK, Ahluwalia TS, van der Most PJ, Pasko D, Zgaga L, Thiering E, Vitart V,. Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study. Lancet Diabetes Endocrinol. 2014;2(9):719-729.

Qi Q, Kilpelainen TO, Downer MK, Tanaka T, Smith CE, Sluijs I, Sonestedt E, Chu AY, Renstrom F, Lin X, Angquist LH, Huang J, Liu Z, Li Y, Asif Ali M, Xu M, Ahluwalia TS, Boer JM, Chen P, Daimon M, Eriksson J, Perola M, Friedlander Y, Gao YT, Heppe DH,. FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals. Hum Mol Genet. 2014;23(25):6961-6972.

Murphy RA, Patel KV, Kritchevsky SB, Houston DK, Newman AB, Koster A, Simonsick EM, Tylvasky FA, Cawthon PM, Harris TB. Weight change, body composition, and risk of mobility disability and mortality in older adults: a population-based cohort study. J Am Geriatr Soc. 2014;62(8):1476-1483.

Houston DK, Tooze JA, Garcia KR, Visser M, Tylavsky FA, Newman AB, Harris TB, Kritchevsky SB. Protein intake and lower extremity physical performance in older adults: the Health ABC Study [abstract]. J Nutr Health Aging. 2014;18(6):632.

Houston DK, Tooze J, Garcia KR, Visser M, Tylavsky FA, Newman AB, Harris TB, Kritchevsky SB. Protein intake and lower extremity physical performance in older adults: the Health ABC Study [abstract]. Gerontologist. 2014;54(Suppl 2):460.

Bowen P, Affuso O, Houston DK. Predictors of physical activity and sedentary behaviors among older African American women: NHANES 2003-2006 [abstract]. Gerontologist. 2014;54(Suppl 2):350.

Mener DJ, Betz J, Houston DK, Strotmeyer ES, Satterfield S, Harris T, Simonsick EM, Lin FR. Association of hearing impairment and incident depression in older adults [abstract]. Gerontologist. 2014;54(Suppl 2):561.

Houston DK, Neiberg RH, Tooze JA, Hausman DB, Johnson MA, Cauley JA, Bauer DC, Shea MK, Schwartz GG, Williamson JD, Harris TB, Kritchevsky SB. Low 25-hydroxyvitamin D predicts the onset of mobility limitation and disability in community-dwelling older adults: the Health ABC Study. J Gerontol A Biol Sci Med Sci. 2013;68(2):181-187.

Nettleton JA, Hivert MF, Lemaitre RN, McKeown NM, Mozaffarian D, Tanaka T, Wojczynski MK, Hruby A, Djousse L, Ngwa JS, Follis JL, Dimitriou M, Ganna A, Houston DK, Kanoni S, Mikkila V, Manichaikul A, Ntalla I, Renstrom F,. Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts. Am J Epidemiol. 2013;177(2):103-115.

Richardson K, Nettleton JA, Rotllan N, Tanaka T, Smith CE, Lai CQ, Parnell LD, Lee YC, Lahti J, Lemaitre RN, Manichaikul A, Keller M, Mikkila V, Ngwa J, van Rooij FJ, Ballentyne CM, Borecki IB, Cupples LA, Garcia M, Hofman A, Ferrucci L,. Gain-of-function lipoprotein lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site. Am J Hum Genet. 2013;92(1):5-14.

Beavers KM, Beavers DP, Houston DK, Harris TB, Hue TF, Koster A, Newman AB, Simonsick EM, Studenski SA, Nicklas BJ, Kritchevsky SB. Associations between body composition and gait-speed decline: results from the Health, Aging, and Body Composition study. Am J Clin Nutr. 2013;97(3):552-560.

Hruby A, Ngwa JS, Renstrom F, Wojczynski MK, Ganna A, Hallmans G, Houston DK, Jacques PF, Kanoni S, Lehtimaki T, Lemaitre RN, Manichaikul A, North KE, Ntalla I, Sonestedt E, Tanaka T, van Rooij FJ, Bandinelli S, Djousse L, Grigoriou E,. Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies. J Nutr. 2013;143(3):345-353.

Peters U, North KE, Sethupathy P, Buyske S, Haessler J, Jiao S, Fesinmeyer MD, Jackson RD, Kuller LH, Rajkovic A, Lim U, Cheng I, Schumacher F, Wilkens L, Li R, Monda K, Ehret G, Nguyen KD, Cooper R, Lewis CE, Leppert M,. A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) study. PLoS Genet. 2013;9(1):e1003171.

Beavers KM, Hsu FC, Houston DK, Beavers DP, Harris TB, Hue TF, Kim LJ, Koster A, Penninx BW, Simonsick EM, Strotmeyer ES, Kritchevsky SB, Nicklas BJ. The role of metabolic syndrome, adiposity, and inflammation in physical performance in the Health ABC Study. J Gerontol A Biol Sci Med Sci. 2013;68(5):617-623.

Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, Cooper JD, Dastani Z, Li R, Houston DK, Wood AR, Michaelsson K, Vandenput L, Zgaga L, Yerges-Armstrong LM, McCarthy MI, Dupuis J, Kaakinen M, Kleber ME, Jameson K,. Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med. 2013;10(2):e1001383.

Tanaka T, Ngwa JS, van Rooij FJ, Zillikens MC, Wojczynski MK, Frazier-Wood AC, Houston DK, Kanoni S, Lemaitre RN, Luan J, Mikkila V, Renstrom F, Sonestedt E, Zhao JH, Chu AY, Qi L, Chasman DI, de Oliveira Otto MC,. Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake. Am J Clin Nutr. 2013;97(6):1395-1402.

Xiao Q, Murphy RA, Houston DK, Harris TB, Chow WH, Park Y. Dietary and supplemental calcium intake and cardiovascular disease mortality: the National Institutes of Health-AARP diet and health study. JAMA Intern Med. 2013;173(8):639-646.

Smith CE, Ngwa J, Tanaka T, Qi Q, Wojczynski MK, Lemaitre RN, Anderson JS, Manichaikul A, Mikkila V, van Rooij FJ, Ye Z, Bandinelli S, Frazier-Wood AC, Houston DK, Hu F, Langenberg C, McKeown NM, Mozaffarian D, North KE,. Lipoprotein receptor-related protein 1 variants and dietary fatty acids: meta-analysis of European origin and African American studies. Int J Obes (Lond). 2013;37(9):1211-1220.

Hansen JG, Hootman K, Tang W, Brannon PM, Kritchevsky S, Houston D, Harris T, Garcia M, Liu Y, Lohman K, Cassano PA. Predictors of serum 25(OH) D in elderly African-Americans in the Health, Aging, and Body Composition (Health ABC) Study [abstract]. FASEB J. 2013;27():245.4.

Gong J, Schumacher F, Lim U, Hindorff LA, Haessler J, Buyske S, Carlson CS, Rosse S, Buzkova P, Fornage M, Gross M, Pankratz N, Pankow JS, Schreiner PJ, Cooper R, Ehret G, Gu CC, Houston D, Irvin MR, Jackson R, Kuller L,. Fine mapping and identification of BMI loci in African Americans. Am J Hum Genet. 2013;93(4):661-671.

Houston DK, Bray GA, Hill JO, Jakicic JM Johnson KC, Leng X, Rejeski W, Kritchevsky SB. Impact of a long-term intensive lifestyle intervention on physical function: the action for health and memory study in diabetes movement [abstract]. Gerontologist. 2013;53(Suppl 1):389.

Rapp S, Bray GA, Hergenroeder AL, Houston DK, Jakicic JM, Kitabchi AE, Van Dorsten B, Williamson JD. Impact of a long-term behavioral weight loss intervention on cognitive function: the Action for Health in Diabetes Movement and Memory Study [abstract]. Gerontologist. 2013;53(Suppl 1):389.

Reardon BJ, Hansen JG, Crystal RG, Houston DK, Kritchevsky SB, Harris T, Lohman K, Liu Y, O'Connor GT, Wilk JB, Mezey J, Gao C, Cassano PA. Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function. BMC Med Genet. 2013;14():122.

Siordia C, Houston DK, Kanaya A, Murphy RA, Simonsick EM, Strotmeyer ES, Newman AB. Prospective assessment of intention, weight loss, and physical mobility [abstract]. Gerontologist. 2013;53(Suppl 1):520-521.

Anderson AL, Harris TB, Tylavsky FA, Perry SE, Houston DK, Lee JS, Kanaya AM, Sahyoun NR. Dietary patterns, insulin sensitivity and inflammation in older adults. Eur J Clin Nutr. 2012;66(1):18-24.

Xu B, Houston DK, Locher JL, Ellison KJ, Gropper S, Buys DR, Zizza CA. Higher Healthy Eating Index-2005 scores are associated with better physical performance. J Gerontol A Biol Sci Med Sci. 2012;67(1):93-99.

Demons JL, Tooze JA, Davis BR, Shertzer-Skinner R, Kearsley L, Gottlieb R, Williamson JD, Houston DK. Vitamin D deficiency is associated with fall-related risk factors in home-bound older adults [abstract]. J Am Geriatr Soc. 2012;60(4 Suppl):S199.

Barbour KE, Houston DK, Cummings SR, Boudreau R, Prasad T, Sheu Y, Bauer DC, Tooze JA, Kritchevsky SB, Tylavsky FA, Harris TB, Cauley JA. Calciotropic hormones and the risk of hip and nonspine fractures in older adults: the Health ABC Study. J Bone Miner Res. 2012;27(5):1177-1185.

Xu B, Houston D, Locher JL, Zizza C. The association between Healthy Eating Index-2005 scores and disability among older Americans. Age Ageing. 2012;41(3):365-371.

Houston DK, Tooze JA, Demons JL, Davis B, Shertzer-Skinner R, Kearsley L, Gottlieb R, Williamson JD. Improving 25-hydroxyvitamin D status in home-bound elders and its effect on falls [abstract]. J Am Geriatr Soc. 2012;60(Suppl 4):S9.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Gerontology and Geriatric Medicine

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