Profile

Education & Training
  BSWake Forest University1990
  MSWake Forest University1992
  PhDWFU School of Medicine1996
FellowshipJohns Hopkins University School of Medicine1997
  University of Maryland School of Medicine1998
Research Interests
genetics/genome , maternal & child health , model development , molecular biology/molecular me , nutrition
Recent Publications
Li X, Howard TD, Moore WC, Ampleford EJ, Li H, Busse WW, Peters SP, Hawkins GA, Bleecker ER, Meyers DA, et al. Importance of hedgehog interacting protein and other lung function genes in asthma. J Allergy Clin Immunol. 2011; 127(6):1457-1465.


Hixson JE, Shimmin LC, Montasser ME, Kim D-K, Zhong Y, Howard T, Langefeld C, Liu Y, Herrington D, et al. Common variants in the periostin gene influence development of atherosclerosis in young persons. Arterioscler Thromb Vasc Biol. 2011; 31(7):1661-1667.


Gray SB, Langefeld CD, Ziegler JT, Hawkins GA, Wagner JD, Howard TD. Single-nucleotide polymorphisms in the TNF gene are associated with obesity-related phenotypes in vervet monkeys. Obesity (Silver Spring). 2011; 19(7):1427-1432.


Mirabelli MC, Hoppin JA, Chatterjee AB, Isom S, Chen H, Grzywacz JG, Howard TD, Quandt SA, Vallejos QM, Arcury TA. Job activities and respiratory symptoms among farmworkers in North Carolina. Arch Environ Occup Health. 2011; 66(3):178-182.


Howard TD, Ho S-M, Zhang L, Chen J, Cui W, Slager R, Gray S, Hawkins GA, Medvedovic M, Wagner JD. Epigenetic changes with dietary soy in cynomolgus monkeys. PLoS ONE. 2011; 6(10):e26791.


O'Donnell CJ, Kavousi M, Smith AV, Kardia SLR, Feitosa MF, Hwang S-J, Sun YV, Herrington DM, Howard TD, Liu Y, et al. Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction. Circulation. 2011; 124(25):2855-2864.


Shashi V, Kwapil TR, Kaczorowski J, Berry MN, Santos CS, Howard TD, Goradia D, Prasad K, Vaibhav D, Rajarethinam R, et al. Evidence of gray matter reduction and dysfunction in chromosome 22q11.2 deletion syndrome. Psychiatry Res. 2010; 181(1):1-8.




Li X, Howard TD, Zheng SL, Haselkorn T, Peters SP, Meyers DA, Bleecker ER. Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions. J Allergy Clin Immunol. 2010; 125(2):328-335.


Bottema RW, Nolte IM, Howard TD, Koppelman GH, Dubois AE, de Meer G, Kerkhof M, Bleecker ER, Meyers DA, Postma DS. Interleukin 13 and interleukin 4 receptor-alpha polymorphisms in rhinitis and asthma. Int Arch Allergy Immunol. 2010; 153(3):259-267.


Li X, Howard TD, Ampleford EJ, Peters SP, Bleecker ER, Meyers DA. Genome-wide association study of asthma severity using proportional odds model identifies TMEM154 [abstract]. Am J Respir Crit Care Med. 2010; 181(1 Meeting Abstracts):A3728.


Ohar JA, Howard TD, Ampleford EJ, Bleecker ER, Meyers DA. Genome wide association study in mesothelioma [abstract]. Am J Respir Crit Care Med. 2010; 181(1 Meeting Abstracts):A4340.


Shashi V, Howard TD, Keshavan MS, Kaczorowski J, Berry MN, Schoch K, Spence EJ, Kwapil TR. COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome. Psychiatry Res. 2010; 178(2):433-436.


Howard TD, Hsu F-C, Grzywacz JG, Chen H, Quandt SA, Vallejos QM, Whalley LE, Cui W, Padilla S, Arcury TA. Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE. Environ Health Perspect. 2010; 118(10):1395-1399.


Cann JA, Kavanagh K, Jorgensen MJ, Mohanan S, Howard TD, Gray SB, Hawkins GA, Fairbanks LA, Wagner JD. Clinicopathologic characterization of naturally occurring diabetes mellitus in vervet monkeys. Vet Pathol. 2010; 47(4):713-718.


MacClellan LR, Howard TD, Cole JW, Stine OC, Giles WH, O'Connell JR, Wozniak MA, Stern BJ, Mitchell BD, Kittner SJ. Relation of candidate genes that encode for endothelial function to migraine and stroke: the Stroke Prevention in Young Women study. Stroke. 2009; 40(10):e550-e557.


Koppelman GH, Meyers DA, Howard TD, Zheng SL, Hawkins GA, Ampleford EJ, Xu J, Koning H, Bruinenberg M, Bleecker ER, et al. Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness. Am J Respir Crit Care Med. 2009; 180(10):929-935.


Gray SB, Howard TD, Langefeld CD, Hawkins GA, Diallo AF, Wagner JD. Comparative analyses of single-nucleotide polymorphisms in the TNF promoter region provide further validation for the vervet monkey model of obesity. Comp Med. 2009; 59(6):580-588.


Koppelman GH, Meyers DA, Howard TD, Zheng SL, Hawkins GA, Ampleford EA, Xu J, Koning H, Bruinenberg M, Bleecker ER, et al. Identification of protocadherin-1 as a novel susceptibility gene for bronchial hyperresponsiveness and asthma [abstract]. Am J Respir Crit Care Med. 2009; 179(1 Meeting Abstracts):A2447.


Mez JB, Cole JW, Howard TD, Macclellan LR, Stine OC, O'Connell JR, Wozniak MA, Stern BJ, Sorkin JD, Mitchell BD, et al. Evaluation of self-reported ethnicity in a case-control population: the Stroke Prevention in Young Women study. BMC Res Notes. 2009; 2():260.


MacClellan LR, Howard TD, Stine OC, Giles W, O'Connell JR, Cole JW, Wozniak M, Stern B, Mitchell BD, Kittner SJ. Relation of candidate genes that encode for endothelial function to migraine and stroke: the Stroke Prevention in Young Women study [abstract]. Stroke. 2008; 39(2):631.


Sale MM, Furie KL, Hsu F-C, Mychaleckyj JC, Sides EG, Howard TD, Worrall BB, Liu Y, Coull BM, Toole JF, et al. Multiple variants in the transcobalamin 2 and cystathionine beta-synthase genes are associated with homocysteine levels in subjects from the Vitamin Intervention for Stroke Prevention (VISP) trial [abstract]. Stroke. 2008; 39(2):630.


Tseng ZH, Aouizerat BE, Pawlikowska L, Vittinghoff E, Lin F, Whiteman D, Poon A, Herrington D, Howard TD, Varosy PD, et al. Common beta-adrenergic receptor polymorphisms are not associated with risk of sudden cardiac death in patients with coronary artery disease. Heart Rhythm. 2008; 5(6):814-821.


Liu Y, Freedman BI, Burdon KP, Langefeld CD, Howard T, Herrington D, Goff DC Jr, Bowden DW, Wagenknecht LE, Rich SS, et al. Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes. Am J Kidney Dis. 2008; 52(2):242-250.


Smith AK, Lange LA, Ampleford EJ, Meyers DA, Bleecker ER, Howard TD. Association of polymorphisms in CASP10 and CASP8 with FEV1/FVC and bronchial hyperresponsiveness in ethnically diverse asthmatics. Clin Exp Allergy. 2008; 38(11):1738-1744.


Shah SA, Herrington DM, Howard TD, Burke GL, Kao WHLH, Guo XQ, Siscovick DS, Chakravarti A, Lima JA, Bowden DW, et al. Associations between genetic variations in NOS1AP and QT interval duration in four racial/ethnic groups in the Multi-Ethnic Study of Atherosclerosis (MESA) [abstract]. Circulation. 2008; 118(18 Suppl 2):S884.


Kiefer EM, Hoffman E, Howard TD, Jiang R, Mychaleckyj JC, Raffel LJ, Rich S, Rotter JI, Sale MM, Tracy R, et al. Phosphodiesterase 4D gene polymorphisms and lung function in multiethnic population: the MESA-Lung Study [abstract]. Am J Respir Crit Care Med. 2008; 177(Online Abstr Issue):A660.


Howard TD, Liu Y, Langefeld CD, Konvicka K, Beilharz E, Johnson C, Hixson JE, Rotter JI, Chen Y-DI, Herrington DM, et al. Association of 9p21 SNPs with premature atherosclerosis in the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study [abstract]. In: Abstracts of the 58th Annual Meeting of the American Society of Human Genetics; 2008 Nov 11-15; Philadelphia (PA). 2008; ():379.




Howard TD, Liu Y, Saylor G, Giles WH, Wozniak MA, Gallagher M, Steinberg KK, Macko RF, Cole JW, Kittner SJ. Promoter polymorphisms in the nitric oxide synthase 3 gene are associated with ischemic stroke in a replication population of young African-American women [abstract]. Stroke. 2007; 38(2):528.


Lakoski SG, Li L, Langefeld CD, Liu Y, Howard TD, Brosnihan KB, Xu J, Bowden DW, Herrington DM. The association between innate immunity gene (IRAK1) and C-reactive protein in the Diabetes Heart Study. Exp Mol Pathol. 2007; 82(3):280-283.


Mez JB, Cole JW, Yepes M, Howard TD, O'Connell JR, Stine OC, Mitchell BD, Wozniak MA, Stern BJ, Giles WH, et al. Tissue-type plasminogen activator polymorphisms and stroke risk in a biracial population: the Stroke Prevention in Young Women study [abstract]. Stroke. 2007; 38(2):529.


Gray SB, Howard TD, Hawkins GA, Diallo AF, Wagner JD. Single nucleotide polymorphisms of the TNF-alpha gene in captive vervet monkeys (Chlorocebus aethiops) [abstract]. Am J Primatol. 2007; 69(Suppl 1):61-62.


Gray SB, Howard T, Hawkins G, Diallo A, Wagner J. Amylin gene sequence of the amyloidogenic region in the vervet monkey (Chlorocebus aethiops) [abstract]. Diabetes. 2007; 56(Suppl 1):A691.
All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Last Updated 1/27/2012
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