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Allyn Howlett, Ph.D.Wake Forest School of Medicine

Allyn Howlett, Ph.D.

Professor,

Contact Information

Academic: 336-716-8592 | Department: 336-716-8545

Email: ahowlett@wakehealth.edu

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Education & Training

  • B.S., Penn State University, 1971
  • Ph.D., Rutgers State University-New Brunswick, 1976
  • Fellowship, University of Virginia, 1979

Memberships

  • North Carolina Neuroscience So
  • Society for Neuroscience
  • Coll on Probs of Drug Dependen
Allyn Howlett, Ph.D.

Allyn Howlett, Ph.D.

Professor, Physiology & Pharmacology

Research Interests

Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Cannabinoids; Signal Transduction; Endocannabinoids
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Contact Information

Academic: 336-716-8592 | Department: 336-716-8545

Email: ahowlett@wakehealth.edu

Related Links

Recent Publications

Medullary endocannabinoids contribute to the differential resting baroreflex sensitivity in rats with altered brain renin-angiotensin system expression. Schaich CL, Grabenauer M, Thomas BF, Shaltout HA, Gallagher PE, Howlett AC, Diz DI.. Front Physiol. 2016;7():207.

Cannabinoid receptor interacting protein (CRIP1a) attenuates CB1R signaling in neuronal cells. Blume LC, Eldeeb K, Bass CE, Selley DE, Howlett AC.. Cell Signal. 2015;27(3):716-726.

Alterations in the medullary endocannabinoid system contribute to age-related impairment of baroreflex sensitivity. Schaich CL, Shaltout HA, Grabenauer M, Thomas BF, Gallagher PE, Howlett AC, Diz DI.. J Cardiovasc Pharmacol. 2015;65(5):473-479.

Cannabinoid receptor-interacting protein 1a modulates CB1 receptor signaling and regulation. Smith TH, Blume LC, Straiker A, Cox JO, David BG, McVoy JR, Sayers KW, Poklis JL, Abdullah RA, Egertova M, Chen CK, Mackie K, Elphick MR, Howlett AC, Selley DE.. Mol Pharmacol. 2015;87(4):747-765.

Effects of 35 kHz, low-frequency ultrasound application in vitro on human fibroblast morphology and migration patterns. Conner-Kerr T, Malpass G, Steele A, Howlett A.. Ostomy Wound Manage. 2015;61(3):34-41.

Chronic baclofen desensitizes GABAB-mediated G-protein activation and stimulates phosphorylation of kinases in mesocorticolimbic rat brain. Keegan BM, Beveridge TJ, Pezor JJ, Xiao R, Sexton T, Childers SR, Howlett AC.. Neuropharmacology. 2015;95():492-502.

Vasoactive lipid mediators control uterine vascular reactivity at early pregnancy in the transgenic hAGNxhREN rat [abstract]. Pulgar VM, Yamaleyeva LM, Varagic J, McGee CM, Bader M, Dechend R, Howlett AC, Brosnihan KB.. Pregnancy Hypertens. 2015;5(1):8.

Galphai/o-dependent Ca(2+) mobilization and Galphaq-dependent PKCalpha regulation of Ca(2+)-sensing receptor-mediated responses in N18TG2 neuroblastoma cells. Sesay JS, Gyapong RN, Najafi LT, Kabler SL, Diz DI, Howlett AC, Awumey EM.. Neurochem Int. 2015;90():142-151.

Angiotensin II - endocannabinoid interactions in the nucleus of the solitary tract are important for regulation of baroreflex control of heart rate [abstract]. Diz DI, Tommasi EN, Howlett AC, Shaltout HA.. Hypertension. 2015;66(Suppl 1):AP189.

Characterization of bladder function in a cannabinoid receptor type 2 knockout mouse in vivo and in vitro. Campeau L, Fullhase C, Sawada N, Gratzke C, Hedlund P, Howlett AC, Andersson KE.. Neurourol Urodyn. 2014;33(5):566-570.

Increased angiotensin II contraction of the uterine artery at early gestation in a transgenic model of hypertensive pregnancy is reduced by inhibition of endocannabinoid hydrolysis. Pulgar VM, Yamaleyeva LM, Varagic J, McGee CM, Bader M, Dechend R, Howlett AC, Brosnihan KB.. Hypertension. 2014;64(3):619-625.

Regulation of gene expression by tobacco product preparations in cultured human dermal fibroblasts. Malpass GE, Arimilli S, Prasad GL, Howlett AC.. Toxicol Appl Pharmacol. 2014;279(2):211-219.

Amphetamine self-administration attenuates dopamine D2 autoreceptor function. Calipari ES, Sun H, Eldeeb K, Luessen DJ, Feng X, Howlett AC, Jones SR, Chen R.. Neuropsychopharmacology. 2014;39(8):1833-1842.

Blockade of CB1 receptors reveals that elevated medullary endocannabinoids contribute to age-related impairment of baroreflex sensitivity in Sprague-Dawley rats [abstract]. Schaich C, Thomas B, Grabenauer M, Howlett A, Diz D.. FASEB J. 2014;28(1 Suppl):681.4.

Differential blood pressure response in normotensive rats and rats with angiotensin II-dependent hypertension following systemic cannabinoid CB1 receptor blockade [abstract]. Schaich C, Howlett A, Brosnihan K, Diz D.. FASEB J. 2014;28(1 Suppl):1140.11.

Structural analysis of CRIP1a by in silico approaches [abstract]. Rai P, Howlett A, Cowsik SM.. Biochem J. 2014;106(2 Suppl 1):208A.

Acute and chronic systemic CB1 cannabinoid receptor blockade improves blood pressure regulation and metabolic profile in hypertensive (mRen2)27 rats. Schaich CL, Shaltout HA, Brosnihan KB, Howlett AC, Diz DI.. Physiol Rep. 2014;2(8):e12108.

Early phytocannabinoid chemistry to endocannabinoids and beyond. Mechoulam R, Hanus LO, Pertwee R, Howlett AC.. Nat Rev Neurosci. 2014;15(11):757-764.

Blockade of angiotensin-(1-7)-mediated vascular remodeling by a CB2 cannabinoid receptor antagonist [abstract]. Tallant EA, Howlett AC, Gallagher PE.. Hypertension. 2014;64(Suppl 1):A542.

Striatal CB1 and D2 receptors regulate expression of each other, CRIP1A and delta opioid systems. Blume LC, Bass CE, Childers SR, Dalton GD, Roberts DC, Richardson JM, Xiao R, Selley DE, Howlett AC.. J Neurochem. 2013;124(6):808-820.

Conformational characterization of phosphorylated analogs of a peptide mimetic of the fourth cytoplasmic loop of CB1 cannabinoid receptor [abstract]. Ganjiwale AD, Howlett AC, Cowsik SM.. Biophys J. 2013;104(2 Suppl 1):555A.

Hippocampal G alpha q/11 but not G alpha o-coupled receptors are altered in aging. McQuail JA, Davis KN, Miller F, Hampson RE, Deadwyler SA, Howlett AC, Nicolle MM.. Neuropharmacology. 2013;70():63-73.

CB1 cannabinoid receptors promote maximal FAK catalytic activity by stimulating cooperative signaling between receptor tyrosine kinases and integrins in neuronal cells. Dalton GD, Peterson LJ, Howlett AC.. Cell Signal. 2013;25(8):1665-1677.

Cannabinoid receptor interacting protein 1a (CRIP1a) regulates CB1 receptor trafficking [abstract]. Blume LC, Dalton GD, Selley DE, Howlett AC.. FASEB J. 2013;27():1173.11.

CB1 cannabinoid receptor juxtamembrane C-terminal phosphorylation in NT18TG2 cells [abstract]. Eldeeb K, Cowsik SM, Howlett AC.. FASEB J. 2013;27():883.2.

Enhanced CB1 cannabinoid receptor tone contributes to impaired baroreflex sensitivity in hypertensive (mRen2)27 transgenic rats [abstract]. Schaich C, Nautiyal M, Howlett A, Chappell M, Diz D.. FASEB J. 2013;27():926.13.

Complete artificial saliva alters expression of proinflammatory cytokines in human dermal fibroblasts. Malpass GE, Arimilli S, Prasad GL, Howlett AC.. Toxicol Sci. 2013;134(1):18-25.

The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome. Thomas G, Betters JL, Lord CC, Brown AL, Marshall S, Ferguson D, Sawyer J, Davis MA, Melchior JT, Blume LC, Howlett AC, Ivanova PT, Milne SB, Myers DS, Mrak I, Leber V, Heier C, Taschler U, Blankman JL, Cravatt BF, Lee RG, Crooke RM,.. Cell Rep. 2013;5(2):508-520.

The CB2 cannabinoid receptor mediates the anti-proliferative actions of angiotensin-(1-7) in vascular smooth muscle cells [abstract]. Tallant EA, Howlett A, Grabenauer M, Thomas BF, Gallagher PE.. Hypertension. 2013;62(3 Suppl):465.

Chronic systemic CB1 cannabinoid receptor blockade reduces blood pressure and weight gain and improves baroreflex function and heart rate variability in hypertensive (mRen2)27 rats [abstract]. Schaich C, Shaltout HA, Howlett AC, Diz DI.. Hypertension. 2013;62(3 Suppl):183.

The CB2cannabinoid receptor mediates the anti-proliferative actions of angiotensin-(1-7) in vascular smooth muscle cells [abstract]. Tallant EA, Howlett A, Grabenauer M, Thomas BF, Gallagher PE.. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

Elevated endocannabinoids via CB1receptors in the solitary tract nucleus contibute to age-related impairments in baroreflex sensitivity in Sprague-Dawley rats [abstract]. Diz DI, Schaich CL, Thomas BF, Grabenauer MA, Chappell MC, Howlett AC.. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

CB1 cannabinoid receptor phospho-peptides and signal transduction in NT18TG2 cells [abstract]. Eldeeb KM, Howlett AC.. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

Cannabinoid receptor interacting protein 1a (CRIP1a) regulates CB1 receptor signaling and cellular proliferation in a neuronal cell model [abstract]. Blume LC, Eldeeb K, Kabler S, Selley DE, Howlett AC.. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

Functional characterization of a cannabinoid receptor interacting protein 1a (CRIP1a) knockout mouse line reveals anxiolytic-like phenotype [abstract]. Jacob JC, Tomarchio AJ, Shim H, Lichtman AH, Howlett AC, Sim-Selley LJ, Chen CK, Selley DE.. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

Chronic systemic CB1 cannabinoid receptor blockade reduces weight gain and lowers blood pressure in hypertensive (mRen2)27 rats [abstract]. Schaich CL, Howlett A, Thomas B, Grabenauer M, Chappell M, Diz D.. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 Oct 25-27; Richmond (VA). 2013;():.

Chronic systemic CB1 cannabinoid receptor blockade reduces weight gain and lowers blood pressure in hypertensive (mRen2)27 rats [abstract]. Schaich CL, Howlett A, Thomas B, Grabenauer M, Chappell M, Diz D.. In: Conference Program of the 2013 Carolina Cannabinoid Collaborative Conference; 2013 June 21-26; Vancouver (CA). 2013;():.

Effects of palmitoylation of Cys415 in helix 8 of the CB1 cannabinoid receptor on membrane localization and signalling. Oddi S, Dainese E, Sandiford S, Fezza F, Lanuti M, Chiurchiu V, Totaro A, Catanzaro G, Barcaroli D, De Laurenzi V, Centonze D, Mukhopadhyay S, Selent J, Howlett AC, Maccarrone M.. Br J Pharmacol. 2012;165(8):2635-2651.

Cannabinoid CB1 receptors transactivate multiple receptor tyrosine kinases and regulate serine/threonine kinases to activate ERK in neuronal cells. Dalton GD, Howlett AC.. Br J Pharmacol. 2012;165(8):2497-2511.

Mechanical properties of lower limb dermis following static and cyclic compression. Evans DW, Scott AT, Teasdall RD, Smith BP, Howlett A, Connor-Kerr T, Sparks JL.. Biomed Sci Instrum. 2012;48():104-111.

Cannabinoid receptor interacting protein 1a (CRIP1a) regulates CB1 signaling and transcriptional activity [abstract]. Blume LC, Bass CE, Dalton GD, Selley DE, Howlett AC.. FASEB J. 2012;26():837.5.

Contribution of endocannabinoids via CB1 receptors to the impaired baroreflex sensitivity in (mRen2)27 transgenic hypertensive rats [abstract]. Schaich CL, Howlett AC, Diz DI.. Hypertension. 2012;60(3 Suppl):117.

Endocannabinoid tone versus constitutive activity of cannabinoid receptors. Howlett AC, Reggio PH, Childers SR, Hampson RE, Ulloa NM, Deutsch DG.. Br J Pharmacol. 2011;163(7):1329-1343.

Dose-related biphasic modulation of baroreflex sensitivity by the CB1 receptor in rat solitary tract nucleus [abstract]. Schaich CL, Howlett AC, Diz DI.. Hypertension. 2011;58(5):e105.

CB1 cannabinoid receptors and their associated proteins. Howlett AC, Blume LC, Dalton GD.. Curr Med Chem. 2010;17(14):1382-1393.

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2. Pertwee RG, Howlett AC, Abood ME, Alexander SPH, Di Marzo V, Elphick MR, Greasley PJ, Hansen HS, Kunos G, Mackie K, et al.. Pharmacol Rev. 2010;62(4):588-631.

Attenuation of baroreflex sensitivity by cannabinoid receptor activation in rat solitary tract nucleus [abstract]. Schaich CL, Howlett AC, Diz DI.. Hypertension. 2010;56(5):e105.

Conformation of a peptide mimetic of the fourth cytoplasmic loop of the CB1 cannabinoid receptor [abstract]. Chandrashekaran IR, Dike A, Grace RCR, Pagett L, Cowsik SM, Howlett AC.. J Biomol Struct Dyn. 2009;26(6):854.

Cannabinoid regulation of nitric oxide synthase I (nNOS) in neuronal cells. Carney ST, Lloyd ML, MacKinnon SE, Newton DC, Jones JD, Howlett AC, Norford DC.. J Neuroimmune Pharmacol. 2009;4(3):338-349.

Signal transduction via cannabinoid receptors. Dalton GD, Bass CE, Van Horn CG, Howlett AC.. CNS Neurol Disord Drug Targets. 2009;8(6):422-431.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Allyn Howlett, Ph.D.

Allyn Howlett, Ph.D.

Professor, Physiology & Pharmacology

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