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Allyn Howlett, Ph.D.

Allyn Howlett, Ph.D.

Professor, Physiology & Pharmacology
Translational Science Institute
Hypertension and Vascular Research Center
Translational Science Institute

Contact Information

Academic: 336-716-8592 | Department: 336-716-8545

Email: ahowlett@wakehealth.edu

Education & Training

  • Ph.D., Rutgers State University-New Brunswick , 1976
  • B.S., Penn State University , 1971
  • Fellowship, University of Virginia, 1979

Memberships

  • North Carolina Neuroscience So
  • Society for Neuroscience
  • Coll on Probs of Drug Dependen
Allyn Howlett, Ph.D.

Allyn Howlett, Ph.D.

Professor, Physiology & Pharmacology Translational Science Institute
Hypertension and Vascular Research Center
Translational Science Institute

Research Interests

diabetes, engineering/bioengineering, hormones/cytokines/signalling, minority health issues, structural biology, substance abuse

Contact Information

Academic: 336-716-8592 | Department: 336-716-8545

Email: ahowlett@wakehealth.edu

Recent Publications

Blume LC, Bass CE, Childers SR, Dalton GD, Roberts DC, Richardson JM, Xiao R, Selley DE, Howlett AC. Striatal CB1 and D2 receptors regulate expression of each other, CRIP1A and delta opioid systems. J Neurochem. 2013;124(6):808-820.

Ganjiwale AD, Howlett AC, Cowsik SM. Conformational characterization of phosphorylated analogs of a peptide mimetic of the fourth cytoplasmic loop of CB1 cannabinoid receptor [abstract]. Biophys J. 2013;104(2 Suppl 1):555A.

Oddi S, Dainese E, Sandiford S, Fezza F, Lanuti M, Chiurchiu V, Totaro A, Catanzaro G, Barcaroli D, De Laurenzi V, Centonze D, Mukhopadhyay S, Selent J, Howlett AC, Maccarrone M. Effects of palmitoylation of Cys415 in helix 8 of the CB1 cannabinoid receptor on membrane localization and signalling. Br J Pharmacol. 2012;165(8):2635-2651.


Evans DW, Scott AT, Teasdall RD, Smith BP, Howlett A, Connor-Kerr T, Sparks JL. Mechanical properties of lower limb dermis following static and cyclic compression. Biomed Sci Instrum. 2012;48():104-111.

Blume LC, Bass CE, Dalton GD, Selley DE, Howlett AC. Cannabinoid receptor interacting protein 1a (CRIP1a) regulates CB1 signaling and transcriptional activity [abstract]. FASEB J. 2012;26():837.5.

Howlett AC, Reggio PH, Childers SR, Hampson RE, Ulloa NM, Deutsch DG. Endocannabinoid tone versus constitutive activity of cannabinoid receptors. Br J Pharmacol. 2011;163(7):1329-1343.

Schaich CL, Howlett AC, Diz DI. Dose-related biphasic modulation of baroreflex sensitivity by the CB1 receptor in rat solitary tract nucleus [abstract]. Hypertension. 2011;58(5):e105.

Howlett AC, Blume LC, Dalton GD. CB1 cannabinoid receptors and their associated proteins. Curr Med Chem. 2010;17(14):1382-1393.

Pertwee RG, Howlett AC, Abood ME, Alexander SPH, Di Marzo V, Elphick MR, Greasley PJ, Hansen HS, Kunos G, Mackie K, et al. International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2. Pharmacol Rev. 2010;62(4):588-631.

Schaich CL, Howlett AC, Diz DI. Attenuation of baroreflex sensitivity by cannabinoid receptor activation in rat solitary tract nucleus [abstract]. Hypertension. 2010;56(5):e105.

Chandrashekaran IR, Dike A, Grace RCR, Pagett L, Cowsik SM, Howlett AC. Conformation of a peptide mimetic of the fourth cytoplasmic loop of the CB1 cannabinoid receptor [abstract]. J Biomol Struct Dyn. 2009;26(6):854.

Carney ST, Lloyd ML, MacKinnon SE, Newton DC, Jones JD, Howlett AC, Norford DC. Cannabinoid regulation of nitric oxide synthase I (nNOS) in neuronal cells. J Neuroimmune Pharmacol. 2009;4(3):338-349.

Dalton GD, Bass CE, Van Horn CG, Howlett AC. Signal transduction via cannabinoid receptors. CNS Neurol Disord Drug Targets. 2009;8(6):422-431.

Howlett AC. Functional selectivity at receptors for cannabinoids and other lipids In: Neve KA, ed. Functional selectivity of G protein-coupled receptor ligands: new opportunities for drug discovery. New York: Humana Press;2009: 211-242.

Howlett AC, Padgett LW, Shim J-Y. Cannabinoid agonist and inverse agonist regulation of G-protein coupling In: Reggio PH, ed. The cannabinoid receptors. New York: Humana Press;2009: 173-202.

Jones JD, Carney ST, Vrana KE, Norford DC, Howlett AC. Cannabinoid receptor-mediated translocation of NO-sensitive guanylyl cyclase and production of cyclic GMP in neuronal cells. Neuropharmacology. 2008;54(1):23-30.

Gerald TM, Howlett AC, Ward GR, Ho C, Franklin SO. Gene expression of opioid and dopamine systems in mouse striatum: effects of CB1 receptors, age and sex. Psychopharmacology (Berl). 2008;198(4):497-508.

Padgett LW, Howlett AC, Shim JY. Binding mode prediction of conformationally restricted anandamide analogs within the CB1 receptor. J Mol Signal. 2008;3():article 5.

Awumey EM, Howlett AC, Putney JW Jr, Diz DI, Bukoski RD. Ca2+ mobilization through dorsal root ganglion Ca2+-sensing receptor stably expressed in HEK293 cells. Am J Physiol Cell Physiol. 2007;292(5):C1895-1905.

Ward GR, Franklin SO, Gerald TM, Dempsey KT, Clodfelter DE Jr, Krissinger DJ, Patel KM, Vrana KE, Howlett AC. Glucocorticoids plus opioids up-regulate genes that influence neuronal function. Cell Mol Neurobiol. 2007;27(5):651-660.

Sesay JS, Diz DI, Howlett AC, Awumey EM. Ca2+-sensing receptor signaling in mouse neuroblastoma cells: a model for the perivascular sensory nerve Ca2+-sensing receptor [abstract]. Hypertension. 2007;50(4):e124.

Niehaus JL, Liu Y, Wallis KT, Egertova M, Bhartur SG, Mukhopadhyay S, Shi S, He H, Selley DE, Howlett AC, et al. CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a. Mol Pharmacol. 2007;72(6):1557-1566.

McCollum L, Howlett AC, Mukhopadhyay S. Anandamide-mediated CB1/CB2 cannabinoid receptor--independent nitric oxide production in rabbit aortic endothelial cells. J Pharmacol Exp Ther. 2007;321(3):930-937.

Anavi-Goffer S, Fleischer D, Hurst DP, Lynch DL, Barnett-Norris J, Shi S, Lewis DL, Mukhopadhyay S, Howlett AC, Reggio PH, et al. Helix 8 Leu in the CB1 cannabinoid receptor contributes to selective signal transduction mechanisms. J Biol Chem. 2007;282(34):25100-13.

Grace CR, Cowsik SM, Shim J-Y, Welsh WJ, Howlett AC. Unique helical conformation of the fourth cytoplasmic loop of the CB1 cannabinoid receptor in a negatively charged environment. J Struct Biol. 2007;159(3):359-368.

Stephens-Hernandez AB, Livingston JN, Dacons-Brock K, Craft HL, Cameron A, Franklin SO, Howlett AC. Drama-based education to motivate participation in substance abuse prevention. Subst Abuse Treat Prev Policy. 2007;2():article 11.

Gerald TM, Ward GR, Howlett AC, Franklin SO. CB1 knockout mice display significant changes in striatal opioid peptide and D4 dopamine receptor gene expression. Brain Res. 2006;1093(1):20-24.

Mukhopadhyay S, Das S, Williams EA, Moore D, Jones JD, Zahm DS, Ndegele MM, Lechner AJ, Howlett AC. Lipopolysaccharide and cyclic AMP regulation of CB2 cannabinoid receptor levels in rat brain and mouse RAW 264.7 macrophages. J Neuroimmunol. 2006;181(1-2):82-92.

Howlett AC, Mukhopadhyay S, Norford DC. Endocannabinoids and reactive nitrogen and oxygen species in neuropathologies. J Neuroimmune Pharmacol. 2006;1(3):305-316.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Physiology & Pharmacology

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