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Fang-Chi Hsu, Ph.D.Wake Forest School of Medicine

Fang-Chi Hsu, Ph.D.

Associate Professor,




Contact Information

Academic: 336-716-8457 | Department: 336-716-2011

Email: fhsu@wakehealth.edu

Education & Training

  • M.S., Natl Taiwan Univ College of Medicine-Taiwan, 1995
  • Ph.D., Sch Hyg & PH,Johns Hopkins U, 2002
  • Fellowship, Sch Hyg & PH,Johns Hopkins U, 2002

Memberships

  • Am Statistical Assoc
  • Am Soc of Human Genetics
  • Biometric Society
  • Int'l Chinese Statistical Asso
Fang-Chi Hsu, Ph.D.

Fang-Chi Hsu, Ph.D.

Associate Professor, Biostatistical Sciences
Center for Cancer Genomics
Sticht Center on Aging
Center for Diabetes Research
Center for Public Health Genomics

Research Interests

aging, cognition/learning, genetics/genome

Contact Information

Academic: 336-716-8457 | Department: 336-716-2011

Email: fhsu@wakehealth.edu

Recent Publications

Cesari M, Vellas B, Hsu FC, Newman AB, Doss H, King AC, Manini TM, Church T, Gill TM, Miller ME, Pahor M. A physical activity intervention to treat the frailty syndrome in older persons-results from the LIFE-P study. J Gerontol A Biol Sci Med Sci. 2015;70(2):216-222.

Raffield LM, Cox AJ, Hugenschmidt CE, Freedman BI, Langefeld CD, Williamson JD, Hsu F, Maldjian JA, Bowden DW. Heritability and genetic association analysis of neuroimaging measures in the Diabetes Heart Study. Neurobiol Aging. 2015;36(3):1602.e7-15.

Shea MK, Kritchevsky SB, Hsu FC, Nevitt M, Booth SL, Kwoh CK, McAlindon TE, Vermeer C, Drummen N, Harris TB, Womack C, Loeser RF. The association between vitamin K status and knee osteoarthritis features in older adults: the Health, Aging and Body Composition Study. Osteoarthritis Cartilage. 2015;23(3):370-378.

Raffield LM, Cox AJ, Carr JJ, Freedman BI, Hicks PJ, Langefeld CD, Hsu FC, Bowden DW. Analysis of a cardiovascular disease genetic risk score in the Diabetes Heart Study. Acta Diabetol. 2015;52(4):743-751.

Murea M, Hsu FC, Cox AJ, Hugenschmidt CE, Xu J, Adams JN, Raffield LM, Whitlow CT, Maldjian JA, Bowden DW, Freedman BI. Structural and functional assessment of the brain in European Americans with mild-to-moderate kidney disease: Diabetes Heart Study-MIND. Nephrol Dial Transplant. 2015;30(8):1322-1329.

Marceau R, Lu W, Holloway S, Sale MM, Worrall BB, Williams SR, Hsu FC, Tzeng JY. A fast multiple-kernel method with applications to detect gene-environment interaction. Genet Epidemiol. 2015;39(6):456-468.

Raffield LM, Hsu FC, Cox AJ, Carr JJ, Freedman BI, Bowden DW. Predictors of all-cause and cardiovascular disease mortality in type 2 diabetes: Diabetes Heart Study. Diabetol Metab Syndr. 2015;7():58.

Sarwal A, Parry SM, Berry MJ, Hsu FC, Lewis MT, Justus NW, Morris PE, Denehy L, Berney S, Dhar S, Cartwright MS. Interobserver reliability of quantitative muscle sonographic analysis in the critically ill population. J Ultrasound Med. 2015;34(7):1191-1200.

Beavers KM, Hsu FC, Serra MC, Yank V, Pahor M, Nicklas BJ. The effects of a long-term physical activity intervention on serum uric acid in older adults at risk for physical disability. J Aging Phys Act. 2014;22(1):25-33.

Greene-Schloesser D, Payne V, Peiffer AM, Hsu FC, Riddle DR, Zhao W, Chan MD, Metheny-Barlow L, Robbins ME [deceased]. The peroxisomal proliferator-activated receptor (PPAR) alpha agonist, fenofibrate, prevents fractionated whole-brain irradiation-induced cognitive impairment. Radiat Res. 2014;181(1):33-44.

Buford TW, Hsu FC, Brinkley TE, Carter CS, Church TS, Dodson JA, Goodpaster BH, McDermott MM, Nicklas BJ, Yank V, Johnson JA, Pahor M. Genetic influence on exercise-induced changes in physical function among mobility-limited older adults. Physiol Genomics. 2014;46(5):149-158.

Cox AJ, Hsu FC, Ng MC, Langefeld CD, Freedman BI, Carr JJ, Bowden DW. Genetic risk score associations with cardiovascular disease and mortality in the Diabetes Heart Study. Diabetes Care. 2014;37(4):1157-1164.

Williams SR, Yang Q, Chen F, Liu X, Keene KL, Jacques P, Chen WM, Weinstein G, Hsu FC, Beiser A, Wang L, Bookman E, Doheny KF, Wolf PA, Zilka M, Selhub J, Nelson S, Gogarten SM, Worrall BB, Seshadri S, Sale MM. Genome-wide meta-analysis of homocysteine and methionine metabolism identifies five one carbon metabolism loci and a novel association of ALDH1L1 with ischemic stroke. PLoS Genet. 2014;10(3):e1004214.

Huang J, Huffman JE, Yamkauchi M, Trompet S, Asselbergs FW, Sabater-Lleal M, Tregouet DA, Chen WM, Smith NL, Kleber ME, Shin SY, Becker DM, Tang W, Dehghan A, Johnson AD, Truong V, Folkersen L, Yang Q, Oudot-Mellkah T, Buckley BM,. Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2. Arterioscler Thromb Vasc Biol. 2014;34(5):1093-1101.

Liu CK, Leng X, Hsu FC, Kritchevsky SB, Ding J, Earnest CP, Ferrucci L, Goodpaster BH, Guralnik JM, Lenchik L, Pahor M, Fielding RA. The impact of sarcopenia on a physical activity intervention: the Lifestyle Interventions and Independence for Elders Pilot Study (LIFE-P). J Nutr Health Aging. 2014;18(1):59-64.

Wakefield J, Skrivankova V, Hsu FC, Sale M, Heagerty P. Detecting signals in pharmacogenomic genome-wide association studies. Pharmacogenomics J. 2014;14(4):309-315.

Cox AJ, Hugenschmidt CE, Raffield LM, Langefeld CD, Freedman BI, Williamson JD, Hsu FC, Bowden DW. Heritability and genetic association analysis of cognition in the Diabetes Heart Study. Neurobiol Aging. 2014;35(8):1958e3-e12.

Cox AJ, Hsu FC, Freedman BI, Herrington DM, Criqui MH, Carr JJ, Bowden DW. Contributors to mortality in high-risk diabetic patients in the Diabetes Heart Study. Diabetes Care. 2014;37(10):2798-2803.

Tzeng JY, Lu W, Hsu FC. Gene-level pharmacogenetic analysis on survival outcomes using gene-trait similarity regression. Ann Appl Stat. 2014;8(2):1232-1255.

Vaz Fragoso CA, Hsu FC, Brinkley T, Church T, Liu CK, Manini T, Newman AB, Stafford RS, McDermott MM, Gill TM. Combined reduced forced expiratory volume in 1 second (FEV1) and peripheral artery disease in sedentary elders with functional limitations. J Am Med Dir Assoc. 2014;15(9):665-670.

Raffield LM, Agarwal S, Cox AJ, Hsu FC, Carr JJ, Freedman BI, Xu J, Bowden DW, Vitolins MZ. Cross-sectional analysis of calcium intake for associations with vascular calcification and mortality in individuals with type 2 diabetes from the Diabetes Heart Study. Am J Clin Nutr. 2014;100(4):1029-1035.

Buford TW, Hsu FC, Brinkley TE, Carter CS, Church TS, Dodson JA, Goodpaster BH, McDermott MM, Nicklas BJ, Yank V, Johnson JA, Pahor M. The angiotensin-converting enzyme I/D polymorphism and exercise-induced changes in physical function among Caucasian older adults [abstract]. Med Sci Sports Exerc. 2014;46(5 Suppl 1):598.

Keene KL, Chen WM, Chen F, Williams SR, Elkhatib SD, Hsu FC, Mychaleckyj JC, Doheny KF, Pugh EW, Ling H, Laurie CC, Gogarten SM, Madden EB, Worrall BB, Sale MM. Genetic associations with plasma B12, B6, and folate levels in an ischemic stroke population from the Vitamin Intervention for Stroke Prevention (VISP) trial. Front Public Health. 2014;2():112.

Chiu YF, Chung RH, Lee CY, Kao HY, Hou L, Hsu FC. Identification of rare variants for hypertension with incorporation of linkage information. BMC Proc. 2014;8(Suppl 1):S109.

Cox AJ, Hsu FC, Agarwal S, Freedman BI, Herrington DM, Carr JJ, Bowden DW. Prediction of mortality using a multi-bed vascular calcification score in the Diabetes Heart Study. Cardiovasc Diabetol. 2014;13(1):160.

Sun J, Na R, Hsu FC, Zheng SL, Wiklund F, Condreay LD, Trent JM, Xu J. Genetic score is an objective and better measurement of inherited risk of prostate cancer than family history [letter]. Eur Urol. 2013;63(3):585-587.

Beavers KM, Hsu FC, Houston DK, Beavers DP, Harris TB, Hue TF, Kim LJ, Koster A, Penninx BW, Simonsick EM, Strotmeyer ES, Kritchevsky SB, Nicklas BJ. The role of metabolic syndrome, adiposity, and inflammation in physical performance in the Health ABC Study. J Gerontol A Biol Sci Med Sci. 2013;68(5):617-623.

McClain J, Hsu F, Brown E, Burke G, Carr J, Harris T, Kritchevsky S, Szklo M, Tracy R, Ding J. Pericardial adipose tissue and coronary artery calcification in the Multi-ethnic Study of Atherosclerosis (MESA. Obesity (Silver Spring). 2013;21(5):1056-1063.

Shea M, Kritchevsky SB, Hsu F-C, Nevitt MC, Kwoh C, Booth SL, Vermeer C, Loeser RF. Vitamin K status and MRI-based knee osteoarthritis characteristics in community-dwelling older adults: the Health ABC Study [abstract]. Osteoarthritis Cartilage. 2013;21():S152-S153.

Cox AJ, Hsu FC, Carr JJ, Freedman BI, Bowden DW. Glomerular filtration rate and albuminuria predict mortality independently from coronary artery calcified plaque in the Diabetes Heart Study. Cardiovasc Diabetol. 2013;12():68.

Cox AJ, Hugenschmidt CE, Wang PT, Hsu FC, Kenchaiah S, Daniel K, Langefeld CD, Freedman BI, Herrington DM, Carr JJ, Stacey B, Bowden DW. Usefulness of biventricular volume as a predictor of mortality in patients with diabetes mellitus (from the Diabetes Heart Study). Am J Cardiol. 2013;111(8):1152-1158.

Raffield LM, Cox AJ, Hsu FC, Ng MC, Langefeld CD, Carr JJ, Freedman BI, Bowden DW. Impact of HDL genetic risk scores on coronary artery calcified plaque and mortality in individuals with type 2 diabetes from the Diabetes Heart Study. Cardiovasc Diabetol. 2013;12():95.

Chiu Y-F, Lee C-Y, Kao H-Y, Pan W-H, Hsu F-C. Analysis of family- and population-based samples using multiple linkage disequilibrium mapping. Ann Hum Genet. 2013;77():251-267.

Cox AJ, Ng MC, Xu J, Langefeld CD, Koch KL, Dawson PA, Carr JJ, Freedman BI, Hsu FC, Bowden DW. Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study. Atherosclerosis. 2013;229(1):155-160.

Hugenschmidt CE, Hsu FC, Hayasaka S, Carr JJ, Freedman BI, Nyenhuis DL, Williamson JD, Bowden DW. The influence of subclinical cardiovascular disease and related risk factors on cognition in type 2 diabetes mellitus: the DHS-Mind study. J Diabetes Complications. 2013;27(5):422-428.

Schnegg CI, Greene-Schloesser D, Kooshki M, Payne VS, Hsu FC, Robbins ME [deceased]. The PPAR delta agonist GW0742 inhibits neuroinflammation, but does not restore neurogenesis or prevent early delayed hippocampal-dependent cognitive impairment after whole-brain irradiation. Free Radic Biol Med. 2013;61():1-9.

Casanova R, Hsu FC, Sink KM, Rapp SR, Williamson JD, Resnick SM, Espeland MA. Alzheimer's disease risk assessment using large-scale machine learning methods. PLoS One. 2013;8(11):e77949.

Liu C, Hsu F, Beavers KM, Yank V, Stafford RS, Nicklas B, Weiner D, Fielding R. Effectiveness of physical activity on improving a physical performance measure in elders with chronic kidney disease: the lifestyle interventions and independence elders pilot study (LIFE-P) Study [abstract]. Gerontologist. 2013;53(Suppl 1):328.

Shea K, Kritchevsky SB, Hsu F, Booth SL, Nevitt M, Kwoh K, Harrris TB [sic] [Harris TB], Loeser RF. Vitamin K status and knee osteoarthritis progression in older adults: the Health ABC Study [abstract]. Gerontologist. 2013;53(Suppl 1):521.

Sarwal A, Bringolf K, Cartwright M, Hsu FC, Berry M, Bowton D, Dhar S, Morris P. Early serial changes on diaphragm muscle ultrasound may predict duration of mechanical ventilation [abstract]. Crit Care Med. 2013;41(12 Suppl 1):A89-A90.

Schnegg CI, Kooshki M, Hsu F-C, Sui G, Robbins ME. PPAR delta prevents radiation-induced proinflammatory responses in microglia via transrepression of NF-kappaB and inhibition of the PKC alpha/MEK1/2/ERK1/2/AP-1 pathway. Free Radic Biol Med. 2012;52(9):1734-1743.

Tao S, Wang Z, Feng J, Hsu F-C, Jin G, Kim S-T, Zhang Z, Gronberg H, Zheng LS [sic] [Zheng SL], Isaacs WB, Xu J, Sun J. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. Carcinogenesis. 2012;33(3):598-603.

Wang X, Hsu F-C, Isom S, Walkup MP, Kritchevsky SB, Goodpaster BH, Church TS, Pahor M, Stafford RS, Nicklas BJ. Effects of a 12-month physical activity intervention on prevalence of metabolic syndrome in elderly men and women. J Gerontol A Biol Sci Med Sci. 2012;67A(4):417-424.

Cheng Y-C, Anderson CD, Bione S, Keene K, Maguire JM, Nalls M, Rasheed A, Zeginigg M, Attia J, Baker R, Barlera S, Biffi A, Bookman E, Brott TG, Brown RD Jr, Chen F, Chen W-M, Cuisani E, Cole JW, Cortellini L, Danesh J, Hsu F-C, et al. Are myocardial infarction--associated single-nucleotide polymorphisms associated with ischemic stroke?. Stroke. 2012;43(4):980-986.

Newcombe PJ, Reck BH, Sun J, Platek GT, Verzilli C, Kader AK, Kim S-T, Hsu F-C, Zhang Z, Zheng SL, Mooser VE, Condreay LD, Spraggs CF, Whittaker JC, Rittmaster RS, Xu J. A comparison of Bayesian and Frequentist approaches to incorporating external information for the prediction of prostate cancer risk. Genet Epidemiol. 2012;36(1):71-83.

Tao S, Feng J, Webster T, Jin G, Hsu F-C, Chen S-H, Kim S-T, Wang Z, Zhang Z, Zheng SL, Isaacs WB, Xu J, Sun J. Genome-wide two-locus epistasis scans in prostate cancer using two European populations. Hum Genet. 2012;131(7):1225-1234.

Chen SH, Ip EH, Xu J, Sun J, Hsu FC. Using graded response model for the prediction of prostate cancer risk. Hum Genet. 2012;131(8):1327-1336.

Brinkley TE, Hsu FC, Beavers KM, Church TS, Goodpaster BH, Stafford RS, Pahor M, Kritchevsky SB, Nicklas BJ. Total and abdominal adiposity are associated with inflammation in older adults using a factor analysis approach. J Gerontol A Biol Sci Med Sci. 2012;67(10):1099-1106.

Buford TW, Manini TM, Hsu F-C, Cesari M, Anton SD, Nayfield S, Stafford RS, Church TS, Pahor M, Carter CS. Angiotensin-converting enzyme inhibitor use by older adults is associated with greater functional responses to exercise. J Am Geriatr Soc. 2012;60(7):1244-1252.

Lee TC, Greene-Schloesser D, Payne V, Diz DI, Hsu F-C, Kooshki M, Mustafa R, Riddle DR, Zhao W, Chan MD, Robbins ME. Chronic administration of the angiotensin-converting enzyme inhibitor, ramipril, prevents fractionated whole-brain irradiation-induced perirhinal cortex-dependent cognitive impairment. Radiat Res. 2012;178(1):46-56.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Biostatistical Sciences

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