Fang-Chi Hsu, Ph.D.Wake Forest School of Medicine

Fang-Chi Hsu, Ph.D.


Contact Information

Academic: 336-716-8457 | Department: 336-716-2011


Education & Training

  • M.S., Natl Taiwan Univ College of Medicine-Taiwan, 1995
  • Ph.D., Sch Hyg & PH;Johns Hopkins U, 2002
  • Fellowship, Sch Hyg & PH;Johns Hopkins U, 2002


  • Am Statistical Assoc
  • Am Soc of Human Genetics
  • Biometric Society
  • Int'l Chinese Statistical Asso
Fang-Chi Hsu, Ph.D.

Fang-Chi Hsu, Ph.D.

Professor, Biostatistical Sciences

Research Interests

Prostatic Neoplasms; Genetic Predisposition to Disease; Polymorphism, Single Nucleotide; Linkage Disequilibrium; Chromosome Mapping
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Contact Information

Academic: 336-716-8457 | Department: 336-716-2011


Recent Publications

Factors associated with failure to achieve a glycated haemoglobin target of less than 8.0% in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial [research letter]. Drake TC, Hsu FC, Hire D, Chen SH, Cohen RM, McDuffie R, Nylen E, O'Connor P, Rehman S, Seaquist ER.. Diabetes Obes Metab. 2016;18(1):92-95.

Associations between anxiety and depression symptoms and cognitive testing and neuroimaging in type 2 diabetes. Raffield LM, Brenes GA, Cox AJ, Freedman BI, Hugenschmidt CE, Hsu FC, Xu J, Wagner BC, Williamson JD, Maldjian JA, Bowden DW.. J Diabetes Complications. 2016;30(1):143-149.

Shared genetic susceptibility of vascular-related biomarkers with ischemic and recurrent stroke. Williams SR, Hsu FC, Keene KL, Chen WM, Nelson S, Southerland AM, Madden EB, Coull B, Gogarten SM, Furie KL, Dzhivhuho G, Rowles JL, Mehndiratta P, Malik R, Dupuis J, Lin H, Seshadri S, Rich SS, Sale MM, Worrall BB.. Neurology. 2016;86(4):351-359.

Testing and estimation in marker-set association study using semiparametric quantile regression kernel machine. Kong D, Maity A, Hsu FC, Tzeng JY.. Biometrics. 2016;72(2):364-371.

A systematic approach to predicting the risk of unicompartmental knee arthroplasty revision. Zhang G, Smith BP, Plate JF, Casanova R, Hsu FC, Li J, Xia L, Li KC, Poehling GG, Zhou X.. Osteoarthritis Cartilage. 2016;24(6):991-999.

Generalization of rare variant association tests for longitudinal family studies. Chien LC, Hsu FC, Bowden DW, Chiu YF.. Genet Epidemiol. 2016;40(2):101-112.

Analysis of advanced glycation end products in the DHS Mind Study. Adams JN, Martelle SE, Raffield LM, Freedman BI, Langefeld CD, Hsu FC, Maldjian JA, Williamson JD, Hugenschmidt CE, Carr JJ, Cox AJ, Bowden DW.. J Diabetes Complications. 2016;30(2):262-268.

Antihypertensive use and the effect of a physical activity intervention in the prevention of major mobility disability among older adults: the LIFE study. Buford TW, Miller ME, Church TS, Gill TM, Henderson R, Hsu FC, McDermott MM, Nadkarni N, Pahor M, Stafford RS, Carter CS.. J Gerontol A Biol Sci Med Sci. 2016;71(7):974-981.

Analysis of the relationships between type 2 diabetes status, glycemic control, and neuroimaging measures in the Diabetes Heart Study Mind. Raffield LM, Cox AJ, Freedman BI, Hugenschmidt CE, Hsu FC, Wagner BC, Xu J, Maldjian JA, Bowden DW.. Acta Diabetol. 2016;53(3):439-447.

Adding genetic risk score to family history identifies twice as many high-risk men for prostate cancer: results from the Prostate Cancer Prevention Trial. Chen H, Liu X, Brendler CB, Ankerst DP, Leach RJ, Goodman PJ, Lucia MS, Tangen CM, Wang L, Hsu FC, Sun J, Kader AK, Isaacs WB, Helfand BT, Zheng SL, Thompson IM, Platz EA, Xu J.. Prostate. 2016;76(12):1120-1129.

Relationships between measures of adiposity with subclinical atherosclerosis in patients with type 2 diabetes. Yuan M, Hsu FC, Bowden DW, Xu J, Carrie Smith S, Wagenknecht LE, Comeau ME, Divers J, Register TC, Jeffrey Carr J, Langefeld CD, Freedman BI.. Obesity (Silver Spring). 2016;24(8):1810-1818.

Changes in DNA methylation over the growing season differ between North Carolina farmworkers and non-farmworkers. Howard TD, Hsu FC, Chen H, Quandt SA, Talton JW, Summers P, Arcury TA.. Int Arch Occup Environ Health. 2016;():.

A physical activity intervention to treat the frailty syndrome in older persons-results from the LIFE-P study. Cesari M, Vellas B, Hsu FC, Newman AB, Doss H, King AC, Manini TM, Church T, Gill TM, Miller ME, Pahor M.. J Gerontol A Biol Sci Med Sci. 2015;70(2):216-222.

Heritability and genetic association analysis of neuroimaging measures in the Diabetes Heart Study. Raffield LM, Cox AJ, Hugenschmidt CE, Freedman BI, Langefeld CD, Williamson JD, Hsu F, Maldjian JA, Bowden DW.. Neurobiol Aging. 2015;36(3):1602.e7-15.

The association between vitamin K status and knee osteoarthritis features in older adults: the Health, Aging and Body Composition Study. Shea MK, Kritchevsky SB, Hsu FC, Nevitt M, Booth SL, Kwoh CK, McAlindon TE, Vermeer C, Drummen N, Harris TB, Womack C, Loeser RF.. Osteoarthritis Cartilage. 2015;23(3):370-378.

Analysis of a cardiovascular disease genetic risk score in the Diabetes Heart Study. Raffield LM, Cox AJ, Carr JJ, Freedman BI, Hicks PJ, Langefeld CD, Hsu FC, Bowden DW.. Acta Diabetol. 2015;52(4):743-751.

Structural and functional assessment of the brain in European Americans with mild-to-moderate kidney disease: Diabetes Heart Study-MIND. Murea M, Hsu FC, Cox AJ, Hugenschmidt CE, Xu J, Adams JN, Raffield LM, Whitlow CT, Maldjian JA, Bowden DW, Freedman BI.. Nephrol Dial Transplant. 2015;30(8):1322-1329.

A fast multiple-kernel method with applications to detect gene-environment interaction. Marceau R, Lu W, Holloway S, Sale MM, Worrall BB, Williams SR, Hsu FC, Tzeng JY.. Genet Epidemiol. 2015;39(6):456-468.

Predictors of all-cause and cardiovascular disease mortality in type 2 diabetes: Diabetes Heart Study. Raffield LM, Hsu FC, Cox AJ, Carr JJ, Freedman BI, Bowden DW.. Diabetol Metab Syndr. 2015;7():58.

Interobserver reliability of quantitative muscle sonographic analysis in the critically ill population. Sarwal A, Parry SM, Berry MJ, Hsu FC, Lewis MT, Justus NW, Morris PE, Denehy L, Berney S, Dhar S, Cartwright MS.. J Ultrasound Med. 2015;34(7):1191-1200.

Relationships between cognitive performance, neuroimaging and vascular disease: the DHS-MIND study. Hsu FC, Raffield LM, Hugenschmidt CE, Cox A, Xu J, Carr JJ, Freedman BI, Maldjian JA, Williamson JD, Bowden DW.. Neuroepidemiology. 2015;45(1):1-11.

Inflammation as a mediator of the association between race and atrial fibrillation: results from the Health, Aging, and Body Composition study. Dewland TA, Vittinghoff E, Harris TB, Magnani JW, Liu Y, Hsu FC, Satterfield S, Wassel C, Marcus GM.. JACC Clin Electrophysiol. 2015;1(4):248-255.

Insulin dose and cardiovascular mortality in the ACCORD trial. Siraj ES, Rubin DJ, Riddle MC, Miller ME, Hsu FC, Ismail-Beigi F, Chen SH, Ambrosius WT, Thomas A, Bestermann W, Buse JB, Genuth S, Joyce C, Kovacs CS, O'Connor PJ, Sigal RJ, Solomon S.. Diabetes Care. 2015;38(11):2000-2008.

Effects of a one-year physical activity program on serum C-terminal agrin fragment (CAF) concentrations among mobility-limited older adults. Bondoc I, Cochrane SK, Church TS, Dahinden P, Hettwer S, Hsu FC, Stafford RS, Pahor M, Buford TW.. J Nutr Health Aging. 2015;19(9):922-927.

Rare variant association tests for longitudinal family studies [abstract]. Chien LC, Chiu YF, Hsu FC, Bowden D.. Genet Epidemiol. 2015;39(7):538.

Vitamin K status and lower extremity function in older adults: the Health Aging and Body Composition Study. Shea MK, Loeser RF, Hsu FC, Booth SL, Nevitt M, Simonsick EM, Strotmeyer ES, Vermeer C, Kritchevsky SB.. J Gerontol A Biol Sci Med Sci. 2015;():.

Predictors of change in physical function among older adults in response to long-term exercise [abstract]. Layne A, Hsu FC, Blair SN, Chen SH, Fielding R, Hajduk AM, King AC, Buford TW.. Gerontologist. 2015;55(Suppl 2):375.

Multiple geriatric conditions in older adults with chronic kidney disease [abstract]. Liu C, Hsu F, Beavers KM, Kashaf S, Spring B, Newman AB, Weiner D, Fielding R.. Gerontologist. 2015;55(Suppl 2):70.

Dietary acid load and physical function in elderly: Health Aging and Body Composition Study [abstract]. Petrovic S, Hsu F, Kritchevsky SB.. Gerontologist. 2015;55(Suppl 2):748-749.

The effects of a long-term physical activity intervention on serum uric acid in older adults at risk for physical disability. Beavers KM, Hsu FC, Serra MC, Yank V, Pahor M, Nicklas BJ.. J Aging Phys Act. 2014;22(1):25-33.

The peroxisomal proliferator-activated receptor (PPAR) alpha agonist, fenofibrate, prevents fractionated whole-brain irradiation-induced cognitive impairment. Greene-Schloesser D, Payne V, Peiffer AM, Hsu FC, Riddle DR, Zhao W, Chan MD, Metheny-Barlow L, Robbins ME [deceased].. Radiat Res. 2014;181(1):33-44.

Genetic influence on exercise-induced changes in physical function among mobility-limited older adults. Buford TW, Hsu FC, Brinkley TE, Carter CS, Church TS, Dodson JA, Goodpaster BH, McDermott MM, Nicklas BJ, Yank V, Johnson JA, Pahor M.. Physiol Genomics. 2014;46(5):149-158.

Genetic risk score associations with cardiovascular disease and mortality in the Diabetes Heart Study. Cox AJ, Hsu FC, Ng MC, Langefeld CD, Freedman BI, Carr JJ, Bowden DW.. Diabetes Care. 2014;37(4):1157-1164.

Genome-wide meta-analysis of homocysteine and methionine metabolism identifies five one carbon metabolism loci and a novel association of ALDH1L1 with ischemic stroke. Williams SR, Yang Q, Chen F, Liu X, Keene KL, Jacques P, Chen WM, Weinstein G, Hsu FC, Beiser A, Wang L, Bookman E, Doheny KF, Wolf PA, Zilka M, Selhub J, Nelson S, Gogarten SM, Worrall BB, Seshadri S, Sale MM.. PLoS Genet. 2014;10(3):e1004214.

Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2. Huang J, Huffman JE, Yamkauchi M, Trompet S, Asselbergs FW, Sabater-Lleal M, Tregouet DA, Chen WM, Smith NL, Kleber ME, Shin SY, Becker DM, Tang W, Dehghan A, Johnson AD, Truong V, Folkersen L, Yang Q, Oudot-Mellkah T, Buckley BM,.. Arterioscler Thromb Vasc Biol. 2014;34(5):1093-1101.

The impact of sarcopenia on a physical activity intervention: the Lifestyle Interventions and Independence for Elders Pilot Study (LIFE-P). Liu CK, Leng X, Hsu FC, Kritchevsky SB, Ding J, Earnest CP, Ferrucci L, Goodpaster BH, Guralnik JM, Lenchik L, Pahor M, Fielding RA.. J Nutr Health Aging. 2014;18(1):59-64.

Detecting signals in pharmacogenomic genome-wide association studies. Wakefield J, Skrivankova V, Hsu FC, Sale M, Heagerty P.. Pharmacogenomics J. 2014;14(4):309-315.

Heritability and genetic association analysis of cognition in the Diabetes Heart Study. Cox AJ, Hugenschmidt CE, Raffield LM, Langefeld CD, Freedman BI, Williamson JD, Hsu FC, Bowden DW.. Neurobiol Aging. 2014;35(8):1958e3-e12.

Contributors to mortality in high-risk diabetic patients in the Diabetes Heart Study. Cox AJ, Hsu FC, Freedman BI, Herrington DM, Criqui MH, Carr JJ, Bowden DW.. Diabetes Care. 2014;37(10):2798-2803.

Gene-level pharmacogenetic analysis on survival outcomes using gene-trait similarity regression. Tzeng JY, Lu W, Hsu FC.. Ann Appl Stat. 2014;8(2):1232-1255.

Combined reduced forced expiratory volume in 1 second (FEV1) and peripheral artery disease in sedentary elders with functional limitations. Vaz Fragoso CA, Hsu FC, Brinkley T, Church T, Liu CK, Manini T, Newman AB, Stafford RS, McDermott MM, Gill TM.. J Am Med Dir Assoc. 2014;15(9):665-670.

Cross-sectional analysis of calcium intake for associations with vascular calcification and mortality in individuals with type 2 diabetes from the Diabetes Heart Study. Raffield LM, Agarwal S, Cox AJ, Hsu FC, Carr JJ, Freedman BI, Xu J, Bowden DW, Vitolins MZ.. Am J Clin Nutr. 2014;100(4):1029-1035.

The angiotensin-converting enzyme I/D polymorphism and exercise-induced changes in physical function among Caucasian older adults [abstract]. Buford TW, Hsu FC, Brinkley TE, Carter CS, Church TS, Dodson JA, Goodpaster BH, McDermott MM, Nicklas BJ, Yank V, Johnson JA, Pahor M.. Med Sci Sports Exerc. 2014;46(5 Suppl 1):598.

Genetic associations with plasma B12, B6, and folate levels in an ischemic stroke population from the Vitamin Intervention for Stroke Prevention (VISP) trial. Keene KL, Chen WM, Chen F, Williams SR, Elkhatib SD, Hsu FC, Mychaleckyj JC, Doheny KF, Pugh EW, Ling H, Laurie CC, Gogarten SM, Madden EB, Worrall BB, Sale MM.. Front Public Health. 2014;2():112.

Identification of rare variants for hypertension with incorporation of linkage information. Chiu YF, Chung RH, Lee CY, Kao HY, Hou L, Hsu FC.. BMC Proc. 2014;8(Suppl 1):S109.

Prediction of mortality using a multi-bed vascular calcification score in the Diabetes Heart Study. Cox AJ, Hsu FC, Agarwal S, Freedman BI, Herrington DM, Carr JJ, Bowden DW.. Cardiovasc Diabetol. 2014;13():160.

Genetic score is an objective and better measurement of inherited risk of prostate cancer than family history [letter]. Sun J, Na R, Hsu FC, Zheng SL, Wiklund F, Condreay LD, Trent JM, Xu J.. Eur Urol. 2013;63(3):585-587.

The role of metabolic syndrome, adiposity, and inflammation in physical performance in the Health ABC Study. Beavers KM, Hsu FC, Houston DK, Beavers DP, Harris TB, Hue TF, Kim LJ, Koster A, Penninx BW, Simonsick EM, Strotmeyer ES, Kritchevsky SB, Nicklas BJ.. J Gerontol A Biol Sci Med Sci. 2013;68(5):617-623.

Pericardial adipose tissue and coronary artery calcification in the Multi-ethnic Study of Atherosclerosis (MESA. McClain J, Hsu F, Brown E, Burke G, Carr J, Harris T, Kritchevsky S, Szklo M, Tracy R, Ding J.. Obesity (Silver Spring). 2013;21(5):1056-1063.

Vitamin K status and MRI-based knee osteoarthritis characteristics in community-dwelling older adults: the Health ABC Study [abstract]. Shea M, Kritchevsky SB, Hsu F-C, Nevitt MC, Kwoh C, Booth SL, Vermeer C, Loeser RF.. Osteoarthritis Cartilage. 2013;21():S152-S153.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Fang-Chi Hsu, Ph.D.

Fang-Chi Hsu, Ph.D.

Professor, Biostatistical Sciences

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