Christina Elizabeth Hugenschmidt, Ph.D.Wake Forest School of Medicine

Christina Elizabeth Hugenschmidt, Ph.D.

Assistant Professor,

Contact Information

Academic: 336-713-4190 | Department: 336-713-8570

Education & Training

  • B.A., University of North Carolina-Chapel Hill, 1998
  • M.S., University of North Carolina-Chapel Hill, 2000
  • Ph.D., Wake Forest University, 2008
  • Fellowship, Endocrinology, Diabetes and Metabolism, WFU School of Medicine, 2012


  • Org for Human Brain Map
  • Society for Neuroscience
Christina Elizabeth Hugenschmidt, Ph.D.

Christina Elizabeth Hugenschmidt, Ph.D.

Assistant Professor, Gerontology and Geriatric Medicine
Sticht Center on Aging

Research Interests

aging, diabetes, education/training (all f, t,, neurosciences/behavior, radiology imaging/nuclear medi, women's health issues

Contact Information

Academic: 336-713-4190 | Department: 336-713-8570

Recent Publications

Raffield LM, Brenes GA, Cox AJ, Freedman BI, Hugenschmidt CE, Hsu FC, Xu J, Wagner BC, Williamson JD, Maldjian JA, Bowden DW. Associations between anxiety and depression symptoms and cognitive testing and neuroimaging in type 2 diabetes. J Diabetes Complications. 2016;30(1):143-149.

Adams JN, Martelle SE, Raffield LM, Freedman BI, Langefeld CD, Hsu FC, Maldjian JA, Williamson JD, Hugenschmidt CE, Carr JJ, Cox AJ, Bowden DW. Analysis of advanced glycation end products in the DHS Mind Study. J Diabetes Complications. 2016;30(2):262-268.

Batson G, Hugenschmidt CE, Soriano CT. Verbal auditory cueing of improvisational dance: a proposed method for training agency in Parkinson's disease. Front Neurol. 2016;7():15.

Sink KM, Divers J, Whitlow CT, Palmer ND, Smith SC, Xu J, Hugenschmidt CE, Wagner BC, Williamson JD, Bowden DW, Maldjian JA, Freedman BI. Cerebral structural changes in diabetic kidney disease: African American-Diabetes Heart Study MIND. Diabetes Care. 2015;38(2):206-212.

Raffield LM, Cox AJ, Hugenschmidt CE, Freedman BI, Langefeld CD, Williamson JD, Hsu F, Maldjian JA, Bowden DW. Heritability and genetic association analysis of neuroimaging measures in the Diabetes Heart Study. Neurobiol Aging. 2015;36(3):1602.e7-15.

Murea M, Hsu FC, Cox AJ, Hugenschmidt CE, Xu J, Adams JN, Raffield LM, Whitlow CT, Maldjian JA, Bowden DW, Freedman BI. Structural and functional assessment of the brain in European Americans with mild-to-moderate kidney disease: Diabetes Heart Study-MIND. Nephrol Dial Transplant. 2015;30(8):1322-1329.

Hugenschmidt CE, Sink KM. No pain, functional gain: the importance of pain management in older adults with cognitive impairment. Pain. 2015;156(8):1377-1378.

Espeland MA, Brinton RD, Manson JE, Yaffe K, Hugenschmidt C, Vaughan L, Craft S, Edwards BJ, Casanova R, Masaki K, Resnick SM. Postmenopausal hormone therapy, type 2 diabetes mellitus, and brain volumes. Neurology. 2015;85(13):1131-1138.

Hsu FC, Raffield LM, Hugenschmidt CE, Cox A, Xu J, Carr JJ, Freedman BI, Maldjian JA, Williamson JD, Bowden DW. Relationships between cognitive performance, neuroimaging and vascular disease: the DHS-MIND study. Neuroepidemiology. 2015;45(1):1-11.

Whitlow CT, Sink KM, Divers J, Smith SC, Xu J, Palmer ND, Hugenschmidt CE, Williamson JD, Bowden DW, Freedman BI, Maldjian JA. Effects of type 2 diabetes on brain structure and cognitive function: African American-Diabetes Heart Study MIND. AJNR Am J Neuroradiol. 2015;36(9):1648-1653.

Espeland MA, Brinton RD, Hugenschmidt C, Manson JE, Craft S, Yaffe K, Weitlauf J, Vaughan L, Johnson KC, Padula CB, Jackson RD, Resnick SM. Impact of type 2 diabetes and postmenopausal hormone therapy on incidence of cognitive impairment in older women. Diabetes Care. 2015;38(12):2316-2324.

Raffield LM, Cox AJ, Freedman BI, Hugenschmidt CE, Hsu FC, Wagner BC, Xu J, Maldjian JA, Bowden DW. Analysis of the relationships between type 2 diabetes status, glycemic control, and neuroimaging measures in the Diabetes Heart Study Mind. Acta Diabetol. 2015;():.

Hugenschmidt C, Williamson JD. Solving the mystery of the diabetes-dementia connection: new clues--but far from 'case closed' [editorial]. J Diabetes Complications. 2014;28(1):8-9.

Hugenschmidt CE, Burdette JH, Morgan AR, Williamson JD, Kritchevsky SB, Laurienti PJ. Graph theory analysis of functional brain networks and mobility disability in older adults. J Gerontol A Biol Sci Med Sci. 2014;69(11):1399-1406.

Cox AJ, Hugenschmidt CE, Raffield LM, Langefeld CD, Freedman BI, Williamson JD, Hsu FC, Bowden DW. Heritability and genetic association analysis of cognition in the Diabetes Heart Study. Neurobiol Aging. 2014;35(8):1958e3-e12.

Hugenschmidt CE, Lovato JF, Ambrosius WT, Bryan RN, Gerstein HC, Horowitz KR, Launer LJ, Lazar RM, Murray AM, Chew EY, Danis RP, Williamson JD, Miller ME, Ding J. The cross-sectional and longitudinal associations of diabetic retinopathy with cognitive function and brain MRI findings: the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. Diabetes Care. 2014;37(12):3244-3252.

Palmer ND, Sink KM, Smith SC, Xu J, Bowden DW, Hugenschmidt CE, Whitlow CT, Williamson JD, Maldjian JA, Divers J, Freedman BI. Kidney disease and cognitive function: African American-Diabetes Heart Study MIND. Am J Nephrol. 2014;40(3):200-207.

Cox AJ, Hugenschmidt CE, Wang PT, Hsu FC, Kenchaiah S, Daniel K, Langefeld CD, Freedman BI, Herrington DM, Carr JJ, Stacey B, Bowden DW. Usefulness of biventricular volume as a predictor of mortality in patients with diabetes mellitus (from the Diabetes Heart Study). Am J Cardiol. 2013;111(8):1152-1158.

Hugenschmidt CE, Hsu FC, Hayasaka S, Carr JJ, Freedman BI, Nyenhuis DL, Williamson JD, Bowden DW. The influence of subclinical cardiovascular disease and related risk factors on cognition in type 2 diabetes mellitus: the DHS-Mind study. J Diabetes Complications. 2013;27(5):422-428.

Divers J, Hugenschmidt C, Sink KM, Williamson JD, Ge Y, Smith SC, Bowden DW, Whitlow CT, Lyders E, Maldjian JA, Freedman BI. Cerebral white matter hyperintensity in African Americans and European Americans with type 2 diabetes. J Stroke Cerebrovasc Dis. 2013;22(7):e46-52.

Alli R, Hall D, Clarke P, Hugenschmidt C, Rogers S, Sink K, Villalba J, Williams J, Wilson V, Shaw E. An interdisciplinary counseling center for individuals, couples and families afftected by MCI and dementia [abstract]. Alzheimers Dement. 2013;9(4 Suppl):P646.

Neth B, Colmer HG IV, Hugenschmidt C, Fitzsimmons S, Shaw E, Alli R, Sun D, Henningsen D, Mugweru J, Sink K. A brain fitness program for people with dementia concurrent with a support group for their caregivers is feasible [abstract]. Alzheimers Dement. 2013;9(4 Suppl):P647-P648.

Hugenschmidt CE. A link between type 2 diabetes and brain function [commentary]. JAAPA. 2013;26(12):10-11.

Sergeant S, Hugenschmidt CE, Rudock ME, Ziegler JT, Ivester P, Ainsworth HC, Vaidya D, Case LD, Langefeld CD, Freedman BI, Bowden DW, Mathias RA, Chilton FH. Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome. Br J Nutr. 2012;107(4):547-555.

Hugenschmidt CE, Blocker JN, Williamson JD, Nicklas BJ. Preliminary associations between cognition and glucose regulation in obese elderly at risk for type 2 diabetes [abstract]. Diabetes. 2012;61(Suppl 1):A185.

Ding J, Lovato J, Hugenschmidt CE, Ambrosius W, Horowitz K, Bryan RN, Greven C, Gerstein HC, Lazer R, Murray A, Thomas A, Launer L, Williamson J. Retinopathy in relation to cerebral ischemic lesion and cognitive decline in older patients with type 2 diabetes [abstract]. Diabetes. 2012;61(Suppl 1A):LB2.

Mathias RA, Sergeant S, Hugenschmidt CE, Ziegler JT, Ivester P, Case D, Freedman BI, Rudock ME, Langefeld CD, Bowden DW, Chilton FH, et al. The impact of FADS genetic variants on omega-6 polyunsaturated fatty acid metabolism in African Americans. BMC Genet. 2011;12():article 50.

Hayasaka S, Hugenschmidt CE, Laurienti PJ. A network of genes, genetic disorders, and brain areas. PLoS ONE. 2011;6(6):e20907.

Peiffer AM, Hugenschmidt CE, Laurienti PJ. Ethics in 15 min per week. Sci Eng Ethics. 2011;17(2):289-297.

Moussa MN, Vechlekar CD, Burdette JH, Steen MR, Hugenschmidt CE, Laurienti PJ. Changes in cognitive state alter human functional brain networks. Front Hum Neurosci. 2011;5():article 83.

Hugenschmidt C, Hayasaka S, Langefeld C, Freedman B, Carr JJ, Williamson J, Bowden DW. Cognitive performance is related to vascular disease and diabetes in a family study of type 2 diabetes [abstract]. Diabetes. 2011;60(Suppl 1):A225-A226.

Mozolic JL, Hugenschmidt CE, Peiffer AM, Laurienti PJ. Multisensory integration and aging In: Murray MM, Wallace MT, eds. The neural basis of multisensory processes. Boca Raton (FL): CRC Press;2011: 381-395.

Hugenschmidt CE, Hayasaka S, Peiffer AM, Laurienti PJ. Applying capacity analyses to psychophysical evaluation of multisensory interactions. Inf Fusion. 2010;11(1 Special Issue):12-20.

Bowden DW, Cox AJ, Freedman BI, Hugenschimdt CE [sic] [Hugenschmidt CE], Wagenknecht LE, Herrington D, Agarwal S, Register TC, Maldjian JA, Ng MC-Y, Hsu F-C, Langefeld CD, Williamson JD, Carr JJ. Review of the Diabetes Heart Study (DHS) family of studies: a comprehensively examined sample for genetic and epidemiological studies of type 2 diabetes and its complications. Rev Diabet Stud. 2010;7(3):188-201.

Peiffer AM, Hugenschmidt CE, Maldjian JA, Casavona R, Srikanth R, Hayasaka S, Burdette JH, Kraft RA, Laurienti PJ. Aging and the interaction of sensory cortical function and structure. Hum Brain Mapp. 2009;30(1):228-240.

Hugenschmidt CE, Mozolic JL, Laurienti PJ. Suppression of multisensory integration by modality-specific attention in aging. Neuroreport. 2009;20(4):349-353.

Hugenschmidt CE, Mozolic JL, Tan H, Kraft RA, Laurienti PJ. Age-related increase in cross-sensory noise in resting and steady-state cerebral perfusion. Brain Topogr. 2009;21(3-4):241-251.

Hugenschmidt CE, Peiffer AM, McCoy TP, Hayasaka S, Laurienti PJ. Preservation of crossmodal selective attention in healthy aging. Exp Brain Res. 2009;198(2-3):273-285.

Peiffer AM, Hugenschmidt CE, Mozolic J, Laurienti PJ. Do structural MRI analyses show evidence for cognitive reserve in the healthy aging brain? [abstract]. Gerontologist. 2009;49(Suppl 2):306.

Mozolic JL, Hugenschmidt CE, Peiffer AM, Laurienti PJ. Modality-specific selective attention attenuates multisensory integration. Exp Brain Res. 2008;184(1):39-52.

Hugenschmidt CE, Peiffer AM, Kraft RA, Casanova R, Deibler AR, Burdette JH, Maldjian JA, Laurienti PJ. Relating imaging indices of white matter integrity and volume in healthy older adults. Cereb Cortex. 2008;18(2):433-442.

Mozolic JL, Joyner D, Hugenschmidt CE, Peiffer AM, Kraft RA, Maldjian JA, Laurienti PJ. Cross-modal deactivations during modality-specific selective attention. BMC Neurol. 2008;8():article 35.

Peiffer AM, Laurienti PJ, Hugenschmidt CE. Fostering a culture of responsible lab conduct [letter]. Science. 2008;322(5905):1186.

Peiffer AM, Mozolic JL, Hugenschmidt CE, Laurienti PJ. Age-related multisensory enhancement in a simple audiovisual detection task. Neuroreport. 2007;18(10):1077-1081.

Hayasaka S, Peiffer AM, Hugenschmidt CE, Laurienti PJ. Power and sample size calculation for neuroimaging studies by non-central random field theory. Neuroimage. 2007;37(3):721-730.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Assistant Professor, Gerontology and Geriatric Medicine

Christina Elizabeth Hugenschmidt, Ph.D.

Christina Elizabeth Hugenschmidt, Ph.D.

Assistant Professor, Gerontology and Geriatric Medicine
Sticht Center on Aging

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