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William G. Hundley, M.D.Wake Forest School of Medicine

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William G. Hundley, M.D.

Professor,





Clinical Interests

Cardiac Magnetic Resonance Imaging, Cardiology (clinical), Computed Tomography (CT), Echocardiography, Vascular Biology and Function

Contact Information

New Patient Appointments: 336-716-WAKE
Returning Patient Appointments: 336-716-6674
Department: 336-716-6125

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Education & Training

  • B.S., College of William & Mary, 1984
  • M.D., Medical College of Va., VCU, 1988
  • Internship, Parkland Memorial Hosp, 1989
  • Residency, Parkland Memorial Hosp, 1991
  • Fellowship, Parkland Memorial Hosp, 1996

Board Certifications

  • American Board of Internal Medicine, Internal Medicine
  • American Board of Internal Medicine, Internal Medicine, Cardiovascular Disease

NPI Number

  • 1194700484
William G. Hundley, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

William G. Hundley, M.D.

Professor, Cardiology
Comprehensive Cancer Center
Office of Women in Medicine and Science
Sticht Center on Aging
Biomedical Engineering
Radiology

Research Interests

cancer/oncogenesis, cardiac function, education/training (all f, t,, engineering/bioengineering, epidemiology, fitness/physical, health services, research/outc, radiology imaging/nuclear medi

Contact Information

Academic: 336-716-6125 | Department: 336-716-6125

Media Medical Expert »

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Recent Publications

Eng J, McClelland RL, Gomes AS, Hundley WG, Cheng S, Wu CO, Carr JJ, Shea S, Bluemke DA, Lima JA. Adverse left ventricular remodeling and age assessed with cardiac MR imaging: the Multi-Ethnic Study of Atherosclerosis. Radiology. 2016;278(3):714-722.

Ohyama Y, Teixido-Tura G, Ambale-Venkatesh B, Noda C, Chugh AR, Liu CY, Redheuil A, Stacey RB, Dietz H, Gomes AS, Prince MR, Evangelista A, Wu CO, Hundley WG, Bluemke DA, Lima JA. Ten-year longitudinal change in aortic stiffness assessed by cardiac MRI in the second half of the human lifespan: the Multi-Ethnic Study of Atherosclerosis. Eur Heart J Cardiovasc Imaging. 2016;():.

Gjesdal O, Yoneyama K, Mewton N, Wu C, Gomes AS, Hundley G [sic] [Hundley WG], Prince M, Shea S, Liu K, Bluemke DA, Lima JA. Reduced long axis strain is associated with heart failure and cardiovascular events in the Multi-Ethnic Study of Atherosclerosis. J Magn Reson Imaging. 2016;():.

Hall ME, Brinkley TE, Chughtai H, Morgan TM, Hamilton CA, Jordan JH, Stacey RB, Soots S, Hundley WG. Adiposity is associated with gender-specific reductions in left ventricular myocardial perfusion during dobutamine stress. PLoS One. 2016;11(1):e0146519.

Kitzman DW, Brubaker P, Morgan T, Haykowsky M, Hundley G [sic] [Hundley WG], Kraus WE, Eggebeen J, Nicklas BJ. Effect of caloric restriction or aerobic exercise training on peak oxygen consumption and quality of life in obese older patients with heart failure with preserved ejection fraction: a randomized clinical trial. JAMA. 2016;315(1):36-46.

Andersen MM, Kritchevsky SB, Morgan TM, Hire DG, Vasu S, Brinkley TE, Kitzman DW, Hamilton CA, Soots S, Hundley WG. Increased cardiovascular stiffness and impaired age-related functional status. J Gerontol A Biol Sci Med Sci. 2015;70(5):545-553.

Milks MW, Upadhya B, Hall ME, Vasu S, Hundley WG, Stacey RB. Right ventricular stress-induced perfusion defects and late gadolinium enhancement in coronary artery disease. J Comput Assist Tomogr. 2015;39(2):185-188.

Stacey RB, Caine AJ Jr, Hundley WG. Evaluation and management of left ventricular noncompaction cardiomyopathy. Curr Heart Fail Rep. 2015;12(1):61-67.

McEvoy JW, Blaha MJ, DeFilippis AP, Lima JA, Bluemke DA, Hundley WG, Min JK, Shaw LJ, Lloyd-Jones DM, Barr RG, Budoff MJ, Blumenthal RS, Nasir K. Cigarette smoking and cardiovascular events: role of inflammation and subclinical atherosclerosis: the Multiethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2015;35(3):700-709.

Vasu S, Morgan TM, Kitzman DW, Bertoni A, Stacey RB, Hamilton C, Chiles C, Thohan V, Hundley WG. Abnormal stress-related measures of arterial stiffness in middle-aged and elderly men and women with impaired fasting glucose at risk for a first episode of symptomatic heart failure. J Am Heart Assoc. 2015;4(1):e000991.

Chotenimitkhun R, D'Agostino R Jr, Lawrence JA, Hamilton CA, Jordan JH, Vasu S, Lash TL, Yeboah J, Herrington DM, Hundley WG. Chronic statin administration may attenuate early anthracycline-associated declines in left ventricular ejection function. Can J Cardiol. 2015;31(3):302-307.

Liu CY, Chen D, Bluemke DA, Wu CO, Teixido-Tura G, Chugh A, Vasu S, Lima JA, Hundley WG. Evolution of aortic wall thickness and stiffness with atherosclerosis: long-term follow up from the Multi-Ethnic Study of Atherosclerosis. Hypertension. 2015;65(5):1015-1019.

McEvoy JW, Nasir K, DeFilippis AP, Lima JA, Bluemke DA, Hundley WG, Barr RG, Budoff MJ, Szklo M, Navas-Acien A, Polak JF, Blumenthal RS, Post WS, Blaha MJ. Relationship of cigarette smoking with inflammation and subclinical vascular disease: the Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2015;35(4):1002-1010.

Yi CJ, Wu CO, Tee M, Liu CY, Volpe GJ, Prince MR, Hundley GW [sic] [Hundley WG], Gomes AS, van der Geest RJ, Heckbert S, Lima JA, Bluemke DA. The association between cardiovascular risk and cardiovascular magnetic resonance measures of fibrosis: the Multi-Ethnic Study of Atherosclerosis (MESA). J Cardiovasc Magn Reson. 2015;17(1):15.

Vasu S, Little WC, Morgan TM, Stacey RB, Ntim WO, Hamilton C, Thohan V, Chiles C, Hundley WG. Mechanism of decreased sensitivity of dobutamine associated left ventricular wall motion analyses for appreciating inducible ischemia in older adults. J Cardiovasc Magn Reson. 2015;17(1):26.

Jordan JH, Vasu S, Morgan T, D'Agostino R, Melendez GC, Hall M, Hamilton C, Arai A, Liu S, Liu C-Y, Lima J, Bluemke D, Hundley W. Myocardial extracellular volume is elevated in cancer survivors treated with anthracycline-based chemotherapy compared to cancer-free peers and newly diagnosed and untreated cancer patients: a single-center observational study of the. J Am Coll Cardiol. 2015;65(10 Suppl):A1081.

Abbasi SA, Hundley WG, Bluemke DA, Jerosch-Herold M, Blankstein R, Petersen SE, Rider OJ, Lima JA, Allison MA, Murthy VL, Shah RV. Visceral adiposity and left ventricular remodeling: the Multi-Ethnic Study of Atherosclerosis. Nutr Metab Cardiovasc Dis. 2015;25(7):667-676.

Noda C, Ambale Venkatesh B, Ohyama Y, Liu CY, Chamera E, Redheuil A, Teixido-Tura G, Chugh AR, Wu CO, Hundley GW [sic] [Hundley WG], Bluemke DA, Lima JA. Reproducibility of functional aortic analysis using magnetic resonance imaging: the MESA. Eur Heart J Cardiovasc Imaging. 2015;():.

Whitlock MC, Hundley WG. Noninvasive imaging of flow and vascular function in disease of the aorta. JACC Cardiovasc Imaging. 2015;8(9):1094-1106.

Vera T, D'Agostino RB Jr, Jordan JH, Whitlock MC, Melendez GC, Lamar ZS, Porosnicu M, Bonkovsky HL, Poole LB, Hundley WG. Relation of pre-anthracycline serum bilirubin levels to left ventricular ejection fraction after chemotherapy. Am J Cardiol. 2015;116(11):1752-1755.

Sukpraphrute B, Drafts BC, Rerkpattanapipat P, Morgan TM, Kirkman PM, Ntim WO, Hamilton CA, Cockrum RL, Hundley WG. Prognostic utility of cardiovascular magnetic resonance upright maximal treadmill exercise testing. J Cardiovasc Magn Reson. 2015;17(1):103.

Whitlock MC, Yeboah J, Burke GL, Chen H, Klepin HD, Hundley WG. Cancer and its association with the development of coronary artery calcification: an assessment from the Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc. 2015;4(11):e002533.

Stacey RB, Milks MW, Deutsch C, Upadhya B, Hundley WG, Thohan V. Clinical significance of intermediate left ventricular trabeculations in cardiac magnetic resonance. Acta Cardiol. 2015;70(5):588-593.

Turkbey EB, Jain A, Johnson C, Redheuil A, Arai AE, Gomes AS, Carr J, Hundley WG, Teixido-Tura G, Eng J, Lima JA, Bluemke DA. Determinants and normal values of ascending aortic diameter by age, gender, and race/ethnicity in the Multi-Ethnic Study of Atherosclerosis (MESA). J Magn Reson Imaging. 2014;39(2):360-368.

Al-Mallah MH, Nasir K, Katz R, Lima JA, Bluemke DA, Blumenthal RS, Mao S, Hundley WG, Budoff MJ. Relation of thoracic aortic distensibility to left ventricular area (from the Multi-Ethnic Study of Atherosclerosis [MESA]). Am J Cardiol. 2014;113(1):178-182.

Stacey RB, Andersen M, Haag J, Hall ME, McLeod G, Upadhya B, Hundley WG, Thohan V. Right ventricular morphology and systolic function in left ventricular noncompaction cardiomyopathy. Am J Cardiol. 2014;113(6):1018-1023.

Hall ME, Rocco MV, Morgan TM, Hamilton CA, Edwards MS, Jordan JH, Hurie JB, Hundley WG. Chronic diuretic therapy attenuates renal BOLD magnetic resonance response to an acute furosemide stimulus. J Cardiovasc Magn Reson. 2014;16(1):17.

Donekal S, Venkatesh BA, Liu YC, Liu CY, Yoneyama K, Wu CO, Nacif M, Gomes AS, Hundley WG, Bluemke DA, Lima JA. Interstitial fibrosis, left ventricular remodeling, and myocardial mechanical behavior in a population-based multiethnic cohort: the Multi-Ethnic Study of Atherosclerosis (MESA) Study. Circ Cardiovasc Imaging. 2014;7(2):292-302.

Jordan JH, Haag JC, Morgan TM, Vasu S, Stacey B, Hamilton C, Robinson K, Kitzman D, Thohan V, Hundley WG. Small, short-duration, dobutamine-induced perfusion defects are not associated with adverse prognosis in intermediate-risk individuals receiving cardiovascular magnetic resonance stress imaging. J Comput Assist Tomogr. 2014;38(3):427-433.

Wolk MJ, Bailey SR, Doherty JU, Douglas PS, Hendel RC, Kramer CM, Min JK, Patel MR, Rosenbaum L, Shaw LJ, Stainback RF, Allen JM, Brindis RG, Kramer CM, Shaw LJ, Cerqueira MD, Chen J, Dean LS, Fazel R, Hundley WG, Itchhaporia D,. ACCF/AHA/ASE/ASNC/HFSA/HRS/SCAI/SCCT/SCMR/STS 2013 multimodality appropriate use criteria for the detection and risk assessment of stable ischemic heart disease. J Card Fail. 2014;20(2):65-90.

Ronan G, Wolk MJ, Bailey SR, Doherty JU, Douglas PS, Hendel RC, Kramer CM, Min JK, Patel MR, Rosenbaum L, Shaw LJ, Stainback RF, Allen JM, Brindis RG, Kramer CM, Shaw LJ, Cerqueira MD, Chen J, Dean LS, Fazel R, Hundley WG, Itchhaporia D,. ACCF/AHA/ASE/ASNC/HFSA/HRS/SCAI/SCCT/SCMR/STS 2013 multimodality appropriate use criteria for the detection and risk assessment of stable ischemic heart disease. J Nucl Cardiol. 2014;21(1):192-220.

Stacey RB, Andersen MM, St Clair M, Hundley WG, Thohan V. Reply: diagnostic problem of LV hypertrabeculation/noncompaction? [letter]. JACC Cardiovasc Imaging. 2014;7(5):533.

Brinkley TE, Leng X, Chughtai HL, Nicklas BJ, Kritchevsky SB, Ding J, Kitzman DW, Hundley WG. Periaortic fat and cardiovascular risk: a comparison of high-risk older adults and age-matched healthy controls. Int J Obes (Lond). 2014;38(11):1397-1402.

Ambale-Venkatesh B, Armstrong AC, Liu CY, Donekal S, Yoneyama K, Wu CO, Gomes AS, Hundley GW [sic] [Hundley WG], Bluemke DA, Lima JA. Diastolic function assessed from tagged MRI predicts heart failure and atrial fibrillation over an 8-year follow-up period: the multi-ethnic study of atherosclerosis. Eur Heart J Cardiovasc Imaging. 2014;15(4):442-449.

Habibi M, Chahal H, Opdahl A, Gjesdal O, Helle-Valle TM, Heckbert SR, McClelland R, Wu C, Shea S, Hundley G [sic] [Hundley WG], Bluemke DA, Lima JA. Association of CMR-measured LA function with heart failure development: results from the MESA study. JACC Cardiovasc Imaging. 2014;7(6):570-579.

Hundley WG, D'Agostino RB, Hamilton CA, inventors; Wake Forest University Health Sciences, assignee. Workstations with circutis for generating images of global injury. United States patent US 8,660,327. 2014 Feb 25. 2014;():.

Hundley WG, Lane KS, Morgan TM, Hamilton CA, Torti FM, inventors; Wake Forest University Health Sciences, assignee. Tissue evaluation using global characteristics of non-invasive imaging and systems for determining global tissue characteristics of images. Canada patent CA 2,555,373. 2014 Apr 29. 2014;():.

Kongbundansuk S, Hundley WG. Noninvasive imaging of cardiovascular injury related to the treatment of cancer. JACC Cardiovasc Imaging. 2014;7(8):824-838.

Jordan JH, D'Agostino RB Jr, Hamilton CA, Vasu S, Hall ME, Kitzman DW, Thohan V, Lawrence JA, Ellis LR, Lash TL, Hundley WG. Longitudinal assessment of concurrent changes in left ventricular ejection fraction and left ventricular myocardial tissue characteristics after administration of cardiotoxic chemotherapies using T1-weighted and T2-weighted cardiovascular magnetic. Circ Cardiovasc Imaging. 2014;7(6):872-879.

McEvoy JW, Nasir K, DeFilippis AP, Lima JAC, Bluemke DA, Hundley WG, Barr RG, Budoff MJ, Szklo M, Navas-Acien A, Polak JF, Blumenthal RS, Post WS, Blaha MJ. The relationship of cigarette smoking with inflammation and subclinical vascular disease: the Multi-Ethnic Study of Atherosclerosis [abstract]. Ir J Med Sci. 2014;183(Suppl 8):S421.

Zemrak F, Ahlman MA, Captur G, Mohiddin SA, Kawel-Boehm N, Prince MR, Moon JC, Hundley WG, Lima JA, Bluemke DA, Petersen SE. The relationship of left ventricular trabeculation to ventricular function and structure over a 9.5-year follow-up: the MESA study. J Am Coll Cardiol. 2014;64(19):1971-1980.

Redheuil A, Wu CO, Kachenoura N, Ohyama Y, Yan RT, Bertoni AG, Hundley GW, Duprez DA, Jacobs DR Jr, Daniels LB, Darwin C, Sibley C, Bluemke DA, Lima JA. Proximal aortic distensibility is an independent predictor of all-cause mortality and incident CV events: the MESA study. J Am Coll Cardiol. 2014;64(24):2619-2629.

Stacey RB, Haag J, Hall ME, McLeod G, Upadhya B, Hundley WG, Thohan V. Mitral regurgitation in left ventricular noncompaction cardiomyopathy assessed by cardiac MRI. J Heart Valve Dis. 2014;23(5):591-597.

Vera T, Morgan TM, Jordan JH, Whitlock MC, Kitzman D, Hundley WG. Is bilirubin protective against anthracycline-induced cardiomyopathy? [abstract]. Circulation. 2014;130(Suppl 2):A18942.

Vera T, Morgan TM, Jordan JH, Whitlock MC, Vasu S, Hamilton CA, Kitzman D, Little WC, Hundley WG. Pulse wave velocity during dobutamine stress is an independent predictor of MACE in asymptomatic high risk middle aged and elderly men [abstract]. Circulation. 2014;130(Suppl 2):A20316.

Vasu S, Lovato JF, Terry JG, Taylor HA, Fox E, Correa A, Yeboah J, Hundley WG, Carr JJ. Obesity increases aortic stiffness in African-Americans: the Jackson Heart Study [abstract]. J Am Coll Cardiol. 2013;61(10 Suppl 12):E1069.

Haykowsky MJ, Herrington DM, Brubaker PH, Morgan TM, Hundley WG, Kitzman DW. Relationship of flow-mediated arterial dilation and exercise capacity in older patients with heart failure and preserved ejection fraction. J Gerontol A Biol Sci Med Sci. 2013;68(2):161-167.

Eckman DM, Stacey RB, Rowe R, D'Agostino R Jr, Kock ND, Sane DC, Torti FM, Yeboah J, Workman S, Lane KS, Hundley WG. Weekly doxorubicin increases coronary arteriolar wall and adventitial thickness. PLoS One. 2013;8(2):e57554.

Miller CD, Case LD, Little WC, Mahler SA, Burke GL, Harper EN, Lefebvre C, Hiestand B, Hoekstra JW, Hamilton CA, Hundley WG. Stress CMR reduces revascularization, hospital readmission, and recurrent cardiac testing in intermediate-risk patients with acute chest pain. JACC Cardiovasc Imaging. 2013;6(7):785-794.

Drafts BC, Twomley KM, D'Agostino R Jr, Lawrence J, Avis N, Ellis LR, Thohan V, Jordan J, Melin SA, Torti FM, Little WC, Hamilton CA, Hundley WG. Low to moderate dose anthracycline-based chemotherapy is associated with early noninvasive imaging evidence of subclinical cardiovascular disease. JACC Cardiovasc Imaging. 2013;6(8):877-885.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Cardiology

Clinical Interests

Cardiac Magnetic Resonance Imaging, Cardiology (clinical), Computed Tomography (CT), Echocardiography, Vascular Biology and Function

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