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William G. Hundley, M.D.Wake Forest School of Medicine

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William G. Hundley, M.D.

Professor,

Redox Biology & Medicine Ctr


Clinical Interests

Vascular Biology and Function, Cardiac Magnetic Resonance Imaging, Cardiology (clinical), Echocardiography, Computed Tomography (CT)

Contact Information

Returning Patient Appointments: 336-716-6674
Department: 336-716-6125

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Education & Training

  • B.S., College of William & Mary, 1984
  • M.D., Medical College of Va., VCU, 1988
  • Internship, Parkland Memorial Hosp, 1989
  • Residency, Parkland Memorial Hosp, 1991
  • Fellowship, Parkland Memorial Hosp, 1996

Board Certifications

  • American Board of Internal Medicine, Cardiovascular Disease

NPI Number

  • 1194700484
William G. Hundley, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

William G. Hundley, M.D.

Professor, Cardiology
Office of Women in Medicine and Science
Redox Biology & Medicine Ctr
Biomedical Engineering
Radiology

Research Interests

Ventricular Function, Left; Anthracyclines; Antineoplastic Agents; Stroke Volume; Magnetic Resonance Imaging, Cine
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Contact Information

Academic: 336-716-6125 | Department: 336-716-6125

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Recent Publications

Left ventricular hypertrophy by ECG versus cardiac MRI as a predictor for heart failure. Oseni AO, Qureshi WT, Almahmoud MF, Bertoni AG, Bluemke DA, Hundley WG, Lima JA, Herrington DM, Soliman EZ.. Heart. 2017;103(1):49-54.

Reflection magnitude, a measure of arterial stiffness, predicts incident heart failure in men but not women: Multi-Ethnic Study of Atherosclerosis (MESA). Chester RC, Gornbein JA, Hundley WG, Srikanthan P, Watson KE, Horwich T.. J Card Fail. 2017;23(5):353-362.

Multimodality strategy for cardiovascular risk assessment: performance in 2 population-based cohorts. de Lemos JA, Ayers CR, Levine BD, deFilippi CR, Wang TJ, Hundley WG, Berry JD, Seliger SL, McGuire DK, Ouyang P, Drazner MH, Budoff MJ, Greenland P, Ballantyne CM, Khera A.. Circulation. 2017;135(22):2119-2132.

Hypertrabeculated left ventricular myocardium in relationship to myocardial function and fibrosis: the Multi-Ethnic Study of Atherosclerosis. Kawel-Boehm N, McClelland RL, Zemrak F, Captur G, Hundley WG, Liu CY, Moon JC, Petersen SE, Ambale-Venkatesh B, Lima JAC, Bluemke DA.. Radiology. 2017;284(3):667-675.

Racial differences in circulating levels of the soluble receptor for advanced glycation endproducts in middle-aged and older adults. Brinkley TE, Leng X, Nicklas BJ, Kritchevsky SB, Ding J, Kitzman DW, Hundley WG.. Metabolism. 2017;70():98-106.

Frequency of transition from stage A to B or C heart failure after potentially cardiotoxic chemotherapy [abstract]. Jones D, Suerken C, D'Agostino R, Melendez G, Jordan J, Hundley W.. J Am Coll Cardiol. 2017;69(11 Suppl):924.

Decreases in left ventricular mass and not left ventricular ejection fraction are associated with heart failure symptoms in cancer patients six months after potentially cardiotoxic chemotherapy [abstract]. Jordan JH, Melendez G, Suerken C, D'Agostino R, Hundley W.. J Am Coll Cardiol. 2017;69(11 Suppl):1410.

Frequency of left ventricular end-diastolic volume-mediated declines in ejection fraction in patients receiving potentially cardiotoxic cancer treatment. Melendez GC, Sukpraphrute B, D'Agostino RB Jr, Jordan JH, Klepin HD, Ellis L, Lamar Z, Vasu S, Lesser G, Burke GL, Weaver KE, Ntim WO, Hundley WG.. Am J Cardiol. 2017;119(10):1637-1642.

Magnetic resonance imaging of the heart. Hundley WG, Kramer CM, Sanz J. In: Fuster V, Harrington RA, Narula J, Espen ZJ, eds. Hurst's the heart. 14th ed. New York: McGraw-Hill Education;2017: .

Progressive 3-month increase in LV myocardial ECV after anthracycline-based chemotherapy [letter]. Melendez GC, Jordan JH, D'Agostino RB Jr, Vasu S, Hamilton CA, Hundley WG.. JACC Cardiovasc Imaging. 2017;10(6):708-709.

Effect of spironolactone on exercise tolerance and arterial function in older adults with heart failure with preserved ejection fraction. Upadhya B, Hundley WG, Brubaker PH, Morgan TM, Stewart KP, Kitzman DW.. J Am Geriatr Soc. 2017;():.

Three-dimensional volumetric assessment of diastolic function by cardiac magnetic resonance imaging: the Multi-Ethnic Study of Atherosclerosis (MESA). Nacif MS, Almeida ALC, Young AA, Cowan BR, Armstrong AC, Yang E, Sibley CT, Hundley WG, Liu S, Lima JA, Bluemke DA.. Arq Bras Cardiol. 2017;108(6):552-563.

Early myocardial strain changes during potentially cardiotoxic chemotherapy may occur as a result of reductions in left ventricular end-diastolic volume: the need to interpret left ventricular strain with volumes [research letter]. Jordan JH, Sukpraphrute B, Melendez GC, Jolly MP, D'Agostino RB Jr, Hundley WG.. Circulation. 2017;135(25):2575-2577.

Tissue evaluation using global characteristics of non-invasive imaging and systems for determining global tissue characteristics of images. Hamilton CA, Torti FM, Lane KS, Hundley WG, Morgan TM, inventors; Wake Forest University Health Sciences, assignee.. European patent office EP 2314218. 2017 Feb 1. 2017;():.

Aortic arch pulse wave velocity assessed by magnetic resonance imaging as a predictor of incident cardiovascular events: the MESA (Multi-Ethnic Study of Atherosclerosis). Ohyama Y, Ambale-Venkatesh B, Noda C, Kim JY, Tanami Y, Teixido-Tura G, Chugh AR, Redheuil A, Liu CY, Wu CO, Hundley WG, Bluemke DA, Guallar E, Lima JAC.. Hypertension. 2017;70(3):524-530.

Automated assessments of circumferential strain from cine CMR correlate with LVEF declines in cancer patients early after receipt of cardio-toxic chemotherapy. Jolly MP, Jordan JH, Melendez GC, McNeal GR, D'Agostino RB Jr, Hundley WG.. J Cardiovasc Magn Reson. 2017;19(1):59.

Reproducibility of functional aortic analysis using magnetic resonance imaging: the MESA. Noda C, Ambale Venkatesh B, Ohyama Y, Liu CY, Chamera E, Redheuil A, Teixido-Tura G, Chugh AR, Wu CO, Hundley GW [sic] [Hundley WG], Bluemke DA, Lima JA.. Eur Heart J Cardiovasc Imaging. 2016;17(8):909-917.

Adverse left ventricular remodeling and age assessed with cardiac MR imaging: the Multi-Ethnic Study of Atherosclerosis. Eng J, McClelland RL, Gomes AS, Hundley WG, Cheng S, Wu CO, Carr JJ, Shea S, Bluemke DA, Lima JA.. Radiology. 2016;278(3):714-722.

Ten-year longitudinal change in aortic stiffness assessed by cardiac MRI in the second half of the human lifespan: the Multi-Ethnic Study of Atherosclerosis. Ohyama Y, Teixido-Tura G, Ambale-Venkatesh B, Noda C, Chugh AR, Liu CY, Redheuil A, Stacey RB, Dietz H, Gomes AS, Prince MR, Evangelista A, Wu CO, Hundley WG, Bluemke DA, Lima JA.. Eur Heart J Cardiovasc Imaging. 2016;17(9):1044-1053.

Reduced long axis strain is associated with heart failure and cardiovascular events in the Multi-Ethnic Study of Atherosclerosis. Gjesdal O, Yoneyama K, Mewton N, Wu C, Gomes AS, Hundley G [sic] [Hundley WG], Prince M, Shea S, Liu K, Bluemke DA, Lima JA.. J Magn Reson Imaging. 2016;44(1):178-185.

Adiposity is associated with gender-specific reductions in left ventricular myocardial perfusion during dobutamine stress. Hall ME, Brinkley TE, Chughtai H, Morgan TM, Hamilton CA, Jordan JH, Stacey RB, Soots S, Hundley WG.. PLoS One. 2016;11(1):e0146519.

Effect of caloric restriction or aerobic exercise training on peak oxygen consumption and quality of life in obese older patients with heart failure with preserved ejection fraction: a randomized clinical trial. Kitzman DW, Brubaker P, Morgan T, Haykowsky M, Hundley G [sic] [Hundley WG], Kraus WE, Eggebeen J, Nicklas BJ.. JAMA. 2016;315(1):36-46.

Prognosis of low normal left ventricular ejection fraction in an asymptomatic population-based adult cohort: the Multiethnic Study of Atherosclerosis. Yeboah J, Rodriguez CJ, Qureshi W, Liu S, Carr JJ, Lima JA, Hundley WG, Herrington DM.. J Card Fail. 2016;22(10):763-768.

Longitudinal automated assessments of myocardial strain from cine MR in cancer patients receiving cardiotoxic chemotherapy [abstract]. Jolly M-P, Jordan JH, Hamilton CA, Hundley G [sic] [Hundley WG].. J Cardiovasc Magn Reson. 2016;18(Suppl 1):081.

Beta-blocker use is associated with higher renal tissue oxygenation in hypertensive patients suspected of renal artery stenosis. Hall ME, Rocco MV, Morgan TM, Hamilton CA, Jordan JH, Edwards MS, Hall JE, Hundley WG.. Cardiorenal Med. 2016;6(4):261-268.

Fibroblast growth factor-23 and cardiac MRI indices of myocardial fibrosis in the Multi-ethnic Study of Atherosclerosis [abstract]. Almahmoud MF, Herrington D, Hundley W, Jordan J, Kestenbaum B, Katz R, Michos E, Liu CY, Venkatesh BA, Lima J.. J Am Coll Cardiol. 2016;67(13 Suppl):1684.

Refection magnitude, a measure of arterial stiffness, predicts incident congestive heart failure in men but not women: Multi-ethnic Study of Atherosclerosis (MESA) [abstract]. Chester R, Horwich T, Srikanthan P, Gornbein J, Hundley G [sic] [Hundley WG], Watson K.. J Am Coll Cardiol. 2016;67(13 Suppl):1314.

Association of aortic stiffness with left ventricular remodeling and reduced left ventricular function measured by magnetic resonance imaging: the Multi-Ethnic Study of Atherosclerosis. Ohyama Y, Ambale-Venkatesh B, Noda C, Chugh AR, Teixido-Tura G, Kim JY, Donekal S, Yoneyama K, Gjesdal O, Redheuil A, Liu CY, Nakamura T, Wu CO, Hundley WG, Bluemke DA, Lima JA.. Circ Cardiovasc Imaging. 2016;9(7):e004426.

Mediterranean diet score and left ventricular structure and function: the Multi-Ethnic Study of Atherosclerosis. Levitan EB, Ahmed A, Arnett DK, Polak JF, Hundley WG, Bluemke DA, Heckbert SR, Jacobs DR Jr, Nettleton JA.. Am J Clin Nutr. 2016;104(3):595-602.

Anthracycline-associated T1 mapping characteristics are elevated independent of the presence of cardiovascular comorbidities in cancer survivors. Jordan JH, Vasu S, Morgan TM, D'Agostino RB Jr, Melendez GC, Hamilton CA, Arai AE, Liu S, Liu CY, Lima JA, Bluemke DA, Burke GL, Hundley WG.. Circ Cardiovasc Imaging. 2016;9(8):e004325.

Natural history of myocardial function in an adult human population: serial longitudinal observations from MESA. Yoneyama K, Donekal S, Venkatesh BA, Wu CO, Liu CY, Souto Nacif M, Armstrong A, Gomes AS, Hundley WG, McClelland RL, Bluemke DA, Lima JA.. JACC Cardiovasc Imaging. 2016;9(10):1164-1173.

Is myocardial fibrosis a new frontier for discovery in cardiotoxicity related to the administration of anthracyclines? [editorial]. Melendez GC, Hundley WG.. Circ Cardiovasc Imaging. 2016;9(12):e005797.

Impact of aortic size and function assessed by MRI on incident hypertension and blood pressure progression: the Multi-ethnic Study of Atherosclerosis [abstract]. Ohyama Y, Ambale-Venkatesh B, Yoneyama K, Nwabuo C, Noda C, Tura GT, Redheuil A, Gomes A, Hundley G [sic] [Hundley WG], Nakamura T, Bluemke D, Lima J.. Eur Heart J. 2016;37(Suppl 1):1203.

Diagnostic tests in cardio-oncology. Biasillo G, Cardinale D, Nhola LF, Villarraga HR, Jordan JH, Hundley WG. In: Herrmann J ed. Clinical cardio-oncology. Philadelphia (PA): Elsevier;2016: 313.

Increased cardiovascular stiffness and impaired age-related functional status. Andersen MM, Kritchevsky SB, Morgan TM, Hire DG, Vasu S, Brinkley TE, Kitzman DW, Hamilton CA, Soots S, Hundley WG.. J Gerontol A Biol Sci Med Sci. 2015;70(5):545-553.

Right ventricular stress-induced perfusion defects and late gadolinium enhancement in coronary artery disease. Milks MW, Upadhya B, Hall ME, Vasu S, Hundley WG, Stacey RB.. J Comput Assist Tomogr. 2015;39(2):185-188.

Evaluation and management of left ventricular noncompaction cardiomyopathy. Stacey RB, Caine AJ Jr, Hundley WG.. Curr Heart Fail Rep. 2015;12(1):61-67.

Cigarette smoking and cardiovascular events: role of inflammation and subclinical atherosclerosis: the Multiethnic Study of Atherosclerosis. McEvoy JW, Blaha MJ, DeFilippis AP, Lima JA, Bluemke DA, Hundley WG, Min JK, Shaw LJ, Lloyd-Jones DM, Barr RG, Budoff MJ, Blumenthal RS, Nasir K.. Arterioscler Thromb Vasc Biol. 2015;35(3):700-709.

Abnormal stress-related measures of arterial stiffness in middle-aged and elderly men and women with impaired fasting glucose at risk for a first episode of symptomatic heart failure. Vasu S, Morgan TM, Kitzman DW, Bertoni A, Stacey RB, Hamilton C, Chiles C, Thohan V, Hundley WG.. J Am Heart Assoc. 2015;4(1):e000991.

Chronic statin administration may attenuate early anthracycline-associated declines in left ventricular ejection function. Chotenimitkhun R, D'Agostino R Jr, Lawrence JA, Hamilton CA, Jordan JH, Vasu S, Lash TL, Yeboah J, Herrington DM, Hundley WG.. Can J Cardiol. 2015;31(3):302-307.

Evolution of aortic wall thickness and stiffness with atherosclerosis: long-term follow up from the Multi-Ethnic Study of Atherosclerosis. Liu CY, Chen D, Bluemke DA, Wu CO, Teixido-Tura G, Chugh A, Vasu S, Lima JA, Hundley WG.. Hypertension. 2015;65(5):1015-1019.

Relationship of cigarette smoking with inflammation and subclinical vascular disease: the Multi-Ethnic Study of Atherosclerosis. McEvoy JW, Nasir K, DeFilippis AP, Lima JA, Bluemke DA, Hundley WG, Barr RG, Budoff MJ, Szklo M, Navas-Acien A, Polak JF, Blumenthal RS, Post WS, Blaha MJ.. Arterioscler Thromb Vasc Biol. 2015;35(4):1002-1010.

The association between cardiovascular risk and cardiovascular magnetic resonance measures of fibrosis: the Multi-Ethnic Study of Atherosclerosis (MESA). Yi CJ, Wu CO, Tee M, Liu CY, Volpe GJ, Prince MR, Hundley GW [sic] [Hundley WG], Gomes AS, van der Geest RJ, Heckbert S, Lima JA, Bluemke DA.. J Cardiovasc Magn Reson. 2015;17(1):15.

Mechanism of decreased sensitivity of dobutamine associated left ventricular wall motion analyses for appreciating inducible ischemia in older adults. Vasu S, Little WC, Morgan TM, Stacey RB, Ntim WO, Hamilton C, Thohan V, Chiles C, Hundley WG.. J Cardiovasc Magn Reson. 2015;17(1):26.

Myocardial extracellular volume is elevated in cancer survivors treated with anthracycline-based chemotherapy compared to cancer-free peers and newly diagnosed and untreated cancer patients: a single-center observational study of the. Jordan JH, Vasu S, Morgan T, D'Agostino R, Melendez GC, Hall M, Hamilton C, Arai A, Liu S, Liu C-Y, Lima J, Bluemke D, Hundley W.. J Am Coll Cardiol. 2015;65(10 Suppl):A1081.

Visceral adiposity and left ventricular remodeling: the Multi-Ethnic Study of Atherosclerosis. Abbasi SA, Hundley WG, Bluemke DA, Jerosch-Herold M, Blankstein R, Petersen SE, Rider OJ, Lima JA, Allison MA, Murthy VL, Shah RV.. Nutr Metab Cardiovasc Dis. 2015;25(7):667-676.

Noninvasive imaging of flow and vascular function in disease of the aorta. Whitlock MC, Hundley WG.. JACC Cardiovasc Imaging. 2015;8(9):1094-1106.

Relation of pre-anthracycline serum bilirubin levels to left ventricular ejection fraction after chemotherapy. Vera T, D'Agostino RB Jr, Jordan JH, Whitlock MC, Melendez GC, Lamar ZS, Porosnicu M, Bonkovsky HL, Poole LB, Hundley WG.. Am J Cardiol. 2015;116(11):1752-1755.

Prognostic utility of cardiovascular magnetic resonance upright maximal treadmill exercise testing. Sukpraphrute B, Drafts BC, Rerkpattanapipat P, Morgan TM, Kirkman PM, Ntim WO, Hamilton CA, Cockrum RL, Hundley WG.. J Cardiovasc Magn Reson. 2015;17(1):103.

Cancer and its association with the development of coronary artery calcification: an assessment from the Multi-Ethnic Study of Atherosclerosis. Whitlock MC, Yeboah J, Burke GL, Chen H, Klepin HD, Hundley WG.. J Am Heart Assoc. 2015;4(11):e002533.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Cardiology

Clinical Interests

Vascular Biology and Function, Cardiac Magnetic Resonance Imaging, Cardiology (clinical), Echocardiography, Computed Tomography (CT)
William G. Hundley, M.D.

William G. Hundley, M.D.

Professor, Cardiology
Office of Women in Medicine and Science
Redox Biology & Medicine Ctr
Biomedical Engineering
Radiology

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