Edward Hak-Sing Ip, Ph.D.Wake Forest School of Medicine

Edward Hak-Sing Ip, Ph.D.


Contact Information

Academic: 336-716-9833 | Department: 336-716-2011


Education & Training

  • A.M., Stanford University , 1991
  • Ph.D., Stanford University , 1995


  • Psychometric Society
  • Am Statistical Assoc
Edward Hak-Sing Ip, Ph.D.

Edward Hak-Sing Ip, Ph.D.

Professor, Biostatistical Sciences
Sticht Center on Aging
Center for Comparative Medicine Research
Social Sciences & Health Policy

Research Interests

aging, cancer/oncogenesis, cognition/learning, computer science, critical/intensive care medici, diabetes, fitness/physical, health services, research/outc, instrument development, mental disorders/psychiatry/ps, minority health issues, model development, neurosciences/behavior, nutrition, obesity, prevention, rehabilitation, statistics/mathematics, substance abuse, women's health issues

Contact Information

Academic: 336-716-9833 | Department: 336-716-2011


Recent Publications

Rejeski WJ, Bray GA, Chen SH, Clark JM, Evans M, Hill JO, Jakicic JM, Johnson KC, Neiberg R, Ip EH. Aging and physical function in type 2 diabetes: 8 years of an intensive lifestyle intervention. J Gerontol A Biol Sci Med Sci. 2015;70(3):343-351.

Kirk JK, Arcury TA, Ip E, Bell RA, Saldana S, Nguyen HT, Quandt SA. Diabetes symptoms and self-management behaviors in rural older adults. Diabetes Res Clin Pract. 2015;107(1):54-60.

Rejeski WJ, Rushing J, Guralnik JM, Ip EH, King AC, Manini TM, Marsh AP, McDermott MM, Fielding RA, Newman AB, Tudor-Locke C, Gill TM. The MAT-sf: identifying risk for major mobility disability. J Gerontol A Biol Sci Med Sci. 2015;70(5):641-666.

Quandt SA, Ip EH, Kirk JK, Saldana S, Chen SH, Nguyen H, Bell RA, Arcury TA. Assessment of a short diabetes knowledge instrument for older and minority adults. Diabetes Educ. 2014;40(1):68-76.

Grzywacz JG, Arcury TA, Nguyen HT, Saldana S, IP EH, Kirk JK, Bell RA, Quandt SA. Patterns and stability over time of older adults' diabetes-related beliefs. Health Behav and Policy Rev. 2014;1(2):111-121.

Grzywacz JG, Suerken CK, Zapata Roblyer MI, Trejo G, Arcury TA, Ip EH, Lang W, Quandt SA. Physical activity of preschool-aged Latino children in farmworker families. Am J Health Behav. 2014;38(5):717-725.

Zhang Q, Ip EH. Variable assessment in latent class models. Comput Stat Data Anal. 2014;77():146-156.

Murphy RA, Ip EH, Zhang Q, Boudreau RM, Cawthon PM, Newman AB, Tylavsky FA, Visser M, Goodpaster BH, Harris TB. Transition to sarcopenia and determinants of transitions in older adults: a population-based study. J Gerontol A Biol Sci Med Sci. 2014;69(6):751-758.

Schoch K, Harrell W, Hooper SR, Ip EH, Saldana S, Kwapil TR, Shashi V. Applicability of the nonverbal learning disability paradigm for children with 22q11.2 deletion syndrome. J Learn Disabil. 2014;47(2):153-166.

Arcury TA, Trejo G, Suerken CK, Grzywacz JG, Ip EH, Quandt SA. Housing and neighborhood characteristics and Latino farmworker family well-being. J Immigr Minor Health. 2014;():.

Ip EH, Marshall S, Vitolins M, Crandall SJ, Davis S, Miller D, Kronner D, Vaden K, Spangler J. Measuring medical student attitudes and beliefs regarding patients who are obese. Acad Med. 2013;88(2):282-289.

Peiffer AM, Leyrer CM, Greene-Schloesser DM, Shing E, Kearns WT, Hinson WH, Tatter SB, Ip EH, Rapp SR, Robbins ME [deceased], Shaw EG, Chan MD. Neuroanatomical target theory as a predictive model for radiation-induced cognitive decline. Neurology. 2013;80(8):747-753.

Choi SJ, Shively CA, Register TC, Feng X, Stehle J, High K, Ip E, Kritchevsky SB, Nicklas B, Delbono O. Force-generation capacity of single vastus lateralis muscle fibers and physical function decline with age in African green vervet monkeys.. J Gerontol A Biol Sci Med Sci. 2013;68(3):258-267.

Ip EH, Church T, Marshall SA, Zhang Q, Marsh AP, Guralnik J, King AC, Rejeski WJ. Physical activity increases gains in and prevents loss of physical function: results from the LIfestyle interventions and Independence for Elders pilot study. J Gerontol A Biol Sci Med Sci. 2013;68(4):426-432.

Pan JH, Song XY, Ip EH. A Bayesian analysis of generalized latent curve mixture models. Stat Interface. 2013;6(1):27-44.

Miller DP Jr, Spangler JG, Vitolins MZ, Davis SW, Ip EH, Marion GS, Crandall SJ. Are medical students aware of their anti-obesity bias?. Acad Med. 2013;88(7):978-982.

Bell RA, Arcury TA, Ip E, Grzywacz JG, Nguyen H, Kirk JK, Saldana S, Quandt SA. Correlates of physician trust among rural older adults with diabetes. Am J Health Behav. 2013;37(5):660-666.

Nguyen HT, Kirk JK, Arcury TA, Ip EH, Grzywacz JG, Saldana SJ, Bell RA, Quandt SA. Cognitive function is a risk for health literacy in older adults with diabetes. Diabetes Res Clin Pract. 2013;101(2):141-147.

Barnard RT, Marsh AP, Rejeski WJ, Pecorella A, Ip EH. Design and implementation of the mobility assessment tool: software description. BMC Med Inform Decis Mak. 2013;13():73.

Ip E, Zhang Q, Rejeski J, Harris T, Kritchevsky S. Partially ordered mixed hidden Markov model for the disablement process of older adults. J Am Stat Assoc. 2013;108(502):370-384.

Ip EH, Molenberghs G, Chen S-H, Goegebeur Y, De Boeck P. Functionally unidimensional item response models for multivariate binary data. Multivariate Behav Res. 2013;48(4):534-562.

Quandt SA, Reynolds T, Chapman C, Bell RA, Grzywacz JG, Ip EH, Kirk JK, Arcury TA. Older adults' fears about diabetes: using common sense models of disease to understand fear origins and implications for self-management. J Appl Gerontol. 2013;32(7):783-803.

Song XY, Lu ZH, Cai JH, Ip EH. A Bayesian modeling approach for generalized semiparametric structural equation models. Psychometrika. 2013;78(4):624-647.

Nageswaran S, Golden SL, Easterling D, O'Shea TM, Hansen WB, Ip EH. Factors associated with collaboration among agencies serving children with complex chronic conditions. Matern Child Health J. 2013;17(9):1533-1540.

Rejeski WJ, Marsh AP, Anton S, Chen SH, Church T, Gill TM, Guralnik JM, Glynn NW, King AC, Rushing J, Ip EH. The MAT-sf: clinical relevance and validity. J Gerontol A Biol Sci Med Sci. 2013;68(12):1567-1574.

Ip EH, Rejeski WJ, Marsh AP, Barnard R, Chen SH. Psychometric properties of a computerized adaptive test for assessing mobility in older adults using novel video-animation technology. Qual Life Res. 2013;22(8):1907-1915.

Danhauer SC, Case LD, Tedeschi R, Russell G, Vishnevsky T, Triplett K, Ip EH, Avis NE. Predictors of posttraumatic growth in women with breast cancer. Psychooncology. 2013;22(12):2676-2683.

Ip EH, Zhang Q, Schwartz R, Tooze J, Leng X, Han H, Williamson DA. Multi-profile hidden Markov model for mood, dietary intake, and physical activity in an intervention study of childhood obesity. Stat Med. 2013;32(19):3314-3331.

Ip EH, Rahmandad H, Shoham DA, Hammond R, Huang TT, Wang Y, Mabry PL. Reconciling statistical and systems science approaches to public health. Health Educ Behav. 2013;40(Suppl 1):S123-S131.

Fellin RE, Seay JF, Hill RD, Saldana S, Cannon DW, DeVita P, Ip EH, Martin DF, Messier SP. Differences in running mechanics and strength between runners in minimalist and traditional footwear [abstract]. Med Sci Sports Exerc. 2013;45(5 Suppl 1):424.

Ip EH, Saldana S, Chen SH, Kirk JK, Bell RA, Nguyen H, Grzywacz JG, Arcury TA, Quandt SA. Unreliable item or inconsistent person? A study of variation in health beliefs and belief-anchors to biomedical models. J Health Psychol. 2013;():.

Zhang Q, Ip EH. Generalized linear model for partially ordered data. Stat Med. 2012;31(1):56-68.

Sutfin EL, McNamara RS, Blocker JN, Ip EH, O'Brien MC, Wolfson M. Screening and brief intervention for tobacco use by student health providers on college campuses. J Am Coll Health. 2012;60(1):66-73.

Rejeski WJ, Ip EH, Bertoni AG, Bray GA, Evans G, Gregg EW, Zhang Q. Lifestyle change and mobility in obese adults with type 2 diabetes. N Engl J Med. 2012;366(13):1209-1217.

Nageswaran S, Ip EH, Golden SL, O'Shea TM, Easterling D. Inter-agency collaboration in the care of children with complex chronic conditions. Acad Pediatr. 2012;12(3):189-197.

Quandt SA, Ip EH, Saldana S, Arcury TA. Comparing two questionnaires for eliciting CAM use in a multi-ethnic US population of older adults. Eur J Integr Med. 2012;4(2):e205-e211.

Kirk JK, Grzywacz JG, Arcury TA, Ip EH, Nguyen HT, Bell RA, Saldana S, Quandt SA. Performance of health literacy tests among older adults with diabetes. J Gen Intern Med. 2012;27(5):534-540.

Bell R, Arcury T, Ip E, Grzywacz J, Nguyen H, Kirk J, Saldana S, Quandt S. Demographic, health and self-management correlates of physician trust among rural older adults with diabetes [abstract]. Diabetes. 2012;61(Suppl 1):A582.

Miller DP, Crandall S, Vitolins MZ, Davis S, Kronner D, Ip E, Vaden K, Spangler J. New lifestyle: a web-based teaching and learning program for nutrition, exercise, and weight management [abstract]. J Gen Intern Med. 2012;27(Suppl 2):S563.

Vitolins MZ, Crandall S, Miller D, Ip E, Marion G, Spangler JG. Obesity educational interventions in U.S. medical schools: a systematic review and identified gaps. Teach Learn Med. 2012;24(3):267-272.

Chen SH, Ip EH, Xu J, Sun J, Hsu FC. Using graded response model for the prediction of prostate cancer risk. Hum Genet. 2012;131(8):1327-1336.

Arcury TA, Grzywacz JG, Ip EH, Saldana S, Nguyen HT, Bell RA, Kirk JK, Quandt SA. Social integration and diabetes management among rural older adults. J Aging Health. 2012;24(6):899-922.

Shashi V, Veerapandiyan A, Schoch K, Kwapil T, Keshavan M, Ip E, Hooper S. Social skills and associated psychopathology in children with chromosome 22q11.2 deletion syndrome: implications for interventions. J Intellect Disabil Res. 2012;56(Pt 9):865-878.

Chakraborty D, Bernal AJ, Schoch K, Howard TD, Ip EH, Hooper SR, Keshavan MS, Jirtle RL, Shashi V. Dysregulation of DGCR6 and DGCR6L: psychopathological outcomes in chromosome 22q11.2 deletion syndrome. Transl Psychiatry. 2012;2():e105.

Shashi V, Francis A, Hooper SR, Kranz PG, Zapadka M, Schoch K, Ip E, Tandon N, Howard TD, Keshavan MS. Increased corpus callosum volume in children with chromosome 22q11.2 deletion syndrome is associated with neurocognitive deficits and genetic polymorphisms. Eur J Hum Genet. 2012;20(10):1051-1057.

Nguyen HT, Arcury TA, Grzywacz JG, Saldana SJ, Ip EH, Kirk JK, Bell RA, Quandt SA. The association of mental conditions with blood glucose levels in older adults with diabetes. Aging Ment Health. 2012;16(8):950-957.

Grzywacz JG, Arcury TA, Ip EH, Nguyen HT, Saldana S, Reynolds T, Bell RA, Kirk JK, Quandt SA. Cultural basis for diabetes-related beliefs among low- and high-education African American, American Indian, and White older adults. Ethn Dis. 2012;22(4):466-472.

Grzywacz JG, Arcury TA, Saldana S, Kirk JK, Bell RA, Ip E, Quandt SA. Social control in older adults' diabetes self management and well-being. Behav Med. 2012;38(4):115-120.

Ip EHS, Chen SH. Projective item response model for test-independent measurement. Appl Psychol Meas. 2012;36(7):581-601.

Poehling KA, Blocker J, Ip EH, Peters TR, Wolfson M. 2009-2010 seasonal influenza vaccination coverage among college students from 8 universities in North Carolina. J Am Coll Health. 2012;60(8):541-547.

Miller DP, Crandall SJ, Davis S, Ip E, Jamback G, Burns C, Kronner D, Marion G, Spangler JG, Vaden K, Vernon J, Vitolins MZ. NEW lifestyle: a downloadable teaching and learning program for Nutrition, Exercise, and Weight management [tutorial]. MedEdPORTAL. 2012;():ID9256.

Wolfson M, Champion H, McCoy TP, Rhodes SD, Ip EH, Blocker JN, Martin BA, Wagoner KG, O'Brien MC, Sutfin EL, Mitra A, Durant RH. Impact of a randomized campus/community trial to prevent high-risk drinking among college students. Alcohol Clin Exp Res. 2012;36(10):1767-1778.

Mojtabai R, Corey-Lisle PK, Ip EH, Kopeykina I, Haeri S, Cohen LJ, Shumaker S. The Patient Assessment Questionnaire: initial validation of a measure of treatment effectiveness for patients with schizophrenia and schizoaffective disorder. Psychiatry Res. 2012;200(2-3):857-866.

Barkin SL, Gesell SB, Poe EK, Ip EH. Changing overweight Latino preadolescent body mass index: the effect of the parent-child dyad. Clin Pediatr (Phila). 2011;50(1):29-36.

Chen S-H, Ip EH, Wang YJ. Gibbs ensembles for nearly compatible and incompatible conditional models. Comput Stat Data Anal. 2011;55(4):1760-1769.

Veerapandiyan A, Blalock D, Ghosh S, Ip E, Barnes C, Shashi V. The role of cephalometry in assessing velopharyngeal dysfunction in velocardiofacial syndrome. Laryngoscope. 2011;121(4):732-737.

Kirk JK, Grzywacz JG, Chapman C, Arcury TA, Bell RA, Ip EH, Quandt SA. Blood glucose symptom recognition: perspectives of older rural adults. Diabetes Educ. 2011;37(3):363-369.

Grzywacz JG, Arcury TA, Ip EH, Chapman C, Kirk JK, Bell RA, Quandt SA. Older adults' common sense models of diabetes. Am J Health Behav. 2011;35(3):318-333.

Wolfson M, Champion H, Rogers T, Neiberg RH, Barker DC, Talton JW, Ip EH, D'Agostino RB Jr, Parries MT, Easterling D. Evaluation of free to grow: head start partnerships to promote substance-free communities. Eval Rev. 2011;35(2):153-188.

Cai J-H, Song X-Y, Lam K-H, Ip EH-S. A mixture of generalized latent variable models for mixed mode and heterogeneous data. Comput Stat Data Anal. 2011;55(11):2889-2907.

Skelton JA, Goff DC Jr, Ip E, Beech BM. Attrition in a multidisciplinary pediatric weight management clinic. Child Obes. 2011;7(3):185-193.

Nguyen HT, Grzywacz JG, Arcury TA, Chapman C, Kirk JK, Ip EH, Bell RA, Quandt SA. Linking glycemic control and executive function in rural older adults with diabetes mellitus. J Am Geriatr Soc. 2010;58(6):1123-1127.

Van Ness PH, Charpentier PA, Ip EH, Leng X, Murphy TE, Tooze JA, Allore HG. Gerontologic biostatistics: the statistical challenges of clinical research with older study participants. J Am Geriatr Soc. 2010;58(7):1386-1392.

Miller D, Spangler J, Davis S, Ip E, Marion G, Vitolins M, Crandall S. Medical students are unaware of personal bias toward obese patients [abstract]. J Gen Intern Med. 2010;25(Suppl 3):331.

Jones AS, Lillie-Blanton M, Stone VE, Ip EH, Zhang Q, Wilson TE, Cohen MH, Golub ET, Hessol NA. Multi-dimensional risk factor patterns associated with non-use of highly active antiretroviral therapy among human immunodeficiency virus-infected women. Womens Health Issues. 2010;20(5):335-342.

Ip EH, Jones AS, Heckert DA, Zhang Q, Gondolf ED. Latent Markov model for analyzing temporal configuration for violence profiles and trajectories in a sample of batterers. Sociol Methods Res. 2010;39(2):222-255.

Ip E. Video-animation item banking, calibration, and selection using item response theory [abstract]. Gerontologist. 2010;50(Suppl 1):526.

Hsu F-C, Rejeski WJ, Ip EH, Katula JA, Fielding R, Jette AM, Studenski SA, Blair SN, Miller ME. Evaluation of the late life disability instrument in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study. Health Qual Life Outcomes. 2010;8():115.

Ip EH, Wang YJ. Canonical representation of conditionally specified multivariate discrete distributions. J Multivariate Anal. 2009;100(6):1282-1290.

McCoy TP, Ip EH, Blocker JN, Champion H, Rhodes SD, Wagoner KG, Mitra A, Wolfson M. Attrition bias in a U.S. Internet survey of alcohol use among college freshmen. J Stud Alcohol Drugs. 2009;70(4):606-614.

Ip EH, Smits DJM, De Boeck P. Locally dependent linear logistic test model with person covariates. Appl Psychol Meas. 2009;33(7):555-569.

Finch SA, Weiley V, Ip EH, Barkin S. Impact of pediatricians' perceived self-efficacy and confidence on violence prevention counseling: a national study. Matern Child Health J. 2008;12(1):75-82.

Lee Y-H, Ip EH, Fuh C-D. A strategy for controlling item exposure in multidimensional computerized adaptive testing. Educ Psychol Meas. 2008;68(2):215-232.

Rejeski WJ, Ip EH, Marsh AP, Miller ME, Farmer DF. Measuring disability in older adults: the International Classification System of Functioning, Disability and Health (ICF) framework. Geriatr Gerontol Int. 2008;8(1):48-54.

Rijmen F, Ip EH, Rapp S, Shaw EG. Qualitative longitudinal analysis of symptoms in patients with primary and metastatic brain tumours. J R Stat Soc Ser A Stat Soc. 2008;171(Pt 3):739-753.

Barkin SL, Finch SA, Ip EH, Scheindlin B, Craig JA, Steffes J, Weiley V, Slora E, Altman D, Wasserman RC. Is office-based counseling about media use, timeouts, and firearm storage effective? Results from a cluster-randomized, controlled trial. Pediatrics. 2008;122(1):e15-e25.

Wang YJ, Ip EH. Conditionally specified continuous distributions. Biometrika. 2008;95(3):735-746.

Gesell SB, Reynolds EB, Ip EH, Fenlason LC, Pont SJ, Poe EK, Barkin SL. Social influences on self-reported physical activity in overweight Latino children. Clin Pediatr. 2008;47(8):797-802.

Reboussin BA, Ip EH, Wolfson M. Locally dependent latent class models with covariates: an application to under-age drinking in the USA. J R Stat Soc Ser A Stat Soc. 2008;171(4):877-897.

Ip EH, Wang YJ. A note on cuts for contingency tables. J Multivariate Anal. 2008;99(10):2356-2363.

Rejeski WJ, Ip EH, Marsh AP, Zhang Q, Miller ME. Obesity influences transitional states of disability in older adults with knee pain. Arch Phys Med Rehabil. 2008;89(11):2102-2107.

Intagliata V, Ip EH, Gesell SB, Barkin SL. Accuracy of self- and parental perception of overweight among Latino preadolescents. N C Med J. 2008;69(2):88-91.

Barkin S, Scheindlin B, Ip EH, Richardson I, Finch S. Determinants of parental discipline practices: a national sample from primary care practices. Clin Pediatr (Phila). 2007;46(1):64-69.

Brenes GA, Williamson JD, Messier SP, Rejeski WJ, Pahor M, Ip E, Penninx BWJH. Treatment of minor depression in older adults: a pilot study comparing sertraline and exercise. Aging Ment Health. 2007;11(1):61-68.

DuRant RH, Barkin S, Craig JA, Weiley VA, Ip EH, Wasserman RC. Firearm ownership and storage patterns among families with children who receive well-child care in pediatric offices. Pediatrics. 2007;119(6):e1271-1279.

Ip EH. General linear models. Methods Mol Biol. 2007;404():189-211.

Yada K, Ip E, Katoh N. Is this brand ephemeral? A multivariate tree-based decision analysis of new product sustainability. Decis Support Syst. 2007;44(1):223-234.

Gleason JF Jr, Case D, Rapp SR, Ip E, Naughton M, Butler JM Jr, McMullen K, Stieber V, Saconn P, Shaw EG. Symptom clusters in patients with newly-diagnosed brain tumors. J Support Oncol. 2007;5(9):427-33,436.

Wolfson M, DuRant R, Champion H, Ip E, McCoy T, O'Brien MC, Rhodes SD, Sutfin E, Martin BA, Wagoner K. Impact of a group-randomized trial to reduce high risk drinking by college students [abstract]. Alcohol Clin Exp Res. 2007;31(6 Suppl 2):115A.

Barkin S, Ip EH, Finch S, Martin K, Steffes J, Wasserman RM. Clinician practice patterns: linking to community resources for childhood aggression. Clin Pediatr. 2006;45(8):750-756.

All Publications

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