Profile

Sara Jones, Ph.D.Wake Forest School of Medicine

Sara Jones, Ph.D.

Professor,


Contact Information

Academic: 336-716-8355 | Department: 336-716-8533

Email: srjones@wakehealth.edu

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Education & Training

  • B.S., University of Georgia , 1987
  • Ph.D., University of North Carolina-Chapel Hill , 1994

Memberships

  • Research Society On Alcoholism
  • Society for Neuroscience
  • Assn Of Women In Science
Sara Jones, Ph.D.

Sara Jones, Ph.D.

Professor, Physiology & Pharmacology
WFU Primate Center
Institute for Regenerative Medicine

Research Interests

drugs/therapeutic agents pharm, mental disorders/psychiatry/ps, neurosciences/behavior, substance abuse

Contact Information

Academic: 336-716-8355 | Department: 336-716-8533

Email: srjones@wakehealth.edu

Related Links

Recent Publications

Calipari ES, Ferris MJ, Melchior JR, Bermejo K, Salahpour A, Roberts DC, Jones SR. Methylphenidate and cocaine self-administration produce distinct dopamine terminal alterations. Addict Biol. 2014;19(2):145-155.

Yorgason JT, Ferris MJ, Steffensen SC, Jones SR. Frequency-dependent effects of ethanol on dopamine release in the nucleus accumbens. Alcohol Clin Exp Res. 2014;38(2):438-447.


Calipari ES, Ferris MJ, Siciliano CA, Zimmer BA, Jones SR. Intermittent cocaine self-administration produces sensitization of stimulant effects at the dopamine transporter. J Pharmacol Exp Ther. 2014;349(2):192-198.

Karkhanis A, Skelly MJ, Rau A, Yorgason J, Chappell A, Carter E, Jones S, McCool B, Weiner J. Early life stress increases behavioral and neurobiological risk factors of alcohol addiction in male Long Evans rats [abstract]. Alcohol. 2014;48(2):161.

Siciliano CA, Calipari ES, Ferris MJ, Jones SR. Biphasic mechanisms of amphetamine action at the dopamine terminal. J Neurosci. 2014;34(16):5575-5582.

Daigle TL, Ferris MJ, Gainetdinov RR, Sotnikova TD, Urs NM, Jones SR, Caron MG. Selective deletion of GRK2 alters psychostimulant-induced behaviors and dopamine neurotransmission. Neuropsychopharmacology. 2014;39(10):2450-2462.


Calipari ES, Sun H, Eldeeb K, Luessen DJ, Feng X, Howlett AC, Jones SR, Chen R. Amphetamine self-administration attenuates dopamine D2 autoreceptor function. Neuropharmacology. 2014;39(8):1833-1842.


Ferris MJ, Espana RA, Locke JL, Konstantopoulos JK, Rose JH, Chen R, Jones SR. Dopamine transporters govern diurnal variation in extracellular dopamine tone. Proc Natl Acad Sci U S A. 2014;111(26):E2751-2759.

Siciliano CA, Calipari ES, Jones SR. Amphetamine potency varies with dopamine uptake rate across striatal subregions. J Neurochem. 2014;():.

Karkhanis AN, McCool BA, Weiner JL, Jones SR. Social isolation stress augments dopamine and norepinephrine responses to ethanol in the nucleus accumbens and the basolateral amygdala [abstract]. Alcohol Clin Exp Res. 2014;38(Suppl 1):81A.

Melchior JR, Jones SR. Optogenetic insights into ethanol effects on presynaptic dopamine terminal dynamics [abstract]. Alcohol Clin Exp Res. 2014;38(Suppl 1):82A.

Espana RA, Jones SR. Presynaptic dopamine modulation by stimulant self-administration. Front Biosci (Schol Ed). 2013;5():261-276.

Yorgason JT, Espana RA, Konstantopoulos JK, Weiner JL, Jones SR. Enduring increases in anxiety-like behavior and rapid nucleus accumbens dopamine signaling in socially isolated rats. Eur J Neurosci. 2013;37(6):1022-1031.

Ferris MJ, Calipari ES, Yorgason JT, Jones SR. Examining the complex regulation and drug-induced plasticity of dopamine release and uptake using voltammetry in brain slices. ACS Chem Neurosci. 2013;4(5):693-703.

Karkhanis AN, Konstantopoulos J, Locke J, Weiner JL, Jones SR. Social isolation rearing increases dopamine and norepinephrine responses to ethanol and K-opioid receptor activity in nucleus accumbens [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):240A.

Rose JH, Calipari ES, Mathews TA, Jones SR. Divergent dopamine systems may underlie different neurochemical and behavioral responses to ethanol in C57Bl/6J and DBA/2J mice [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):240A.

Weiner JL, Chappell AM, Carter E, Yorgason J, Jones SR, McCool BA. Adolescent social isolation increases behavioral and neurobiological risk factors of alcoholism in male Long Evans rats [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):299A.

Yorgason JT, Schilaty ND, Hedges DM, Jang E, Jones SR, Steffensen SC. Ethanol inhibits dopamine release at terminals in the nucleus accumbens via GABA(B) receptors [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):240A.

Ferris MJ, Calipari ES, Melchior JR, Roberts DC, Espana RA, Jones SR. Paradoxical tolerance to cocaine after initial supersensitivity in drug-use-prone animals. Eur J Neurosci. 2013;38(4):2628-2636.

Calipari ES, Ferris MJ, Zimmer BA, Roberts DC, Jones SR. Temporal pattern of cocaine intake determines tolerance vs sensitization of cocaine effects at the dopamine transporter. Neuropsychopharmacology. 2013;38(12):2385-2392.

Calipari ES, Ferris MJ, Salahpour A, Caron MG, Jones SR. Methylphenidate amplifies the potency and reinforcing effects of amphetamines by increasing dopamine transporter expression. Nat Commun. 2013;4():2720.



Ferris MJ, Calipari ES, Mateo Y, Melchior JR, Roberts DCS, Jones SR. Cocaine self-administration produces pharmacodynamic tolerance: differential effects on the potency of dopamine transporter blockers, releasers, and methylphenidate. Neuropsychopharmacology. 2012;37(7):1708-1716.

Oleson EB, Ferris MJ, Espana RA, Harp J, Jones SR. Effects of the histamine H1 receptor antagonist and benztropine analog diphenylpyraline on dopamine uptake, locomotion and reward. Eur J Pharmacol. 2012;683(1-3):161-165.

Huggins KN, Mathews TA, Locke JL, Szeliga KT, Friedman DP, Bennett AJ, Jones SR. Effects of early life stress on drinking and serotonin system activity in rhesus macaques: 5-hydroxyindoleacetic acid in cerebrospinal fluid predicts brain tissue levels. Alcohol. 2012;46(4):371-376.


Chappell AM, Carter E, Yorgason JT, Jones SR, McCool BA, Weiner JL. Juvenile social isolation in rats increases behavioral and neurobiological risk factors of alcoholism [abstract]. Alcohol Clin Exp Res. 2012;36(Suppl 2):51A.

Calipari ES, Huggins KN, Mathews TA, Jones SR. Conserved dorsal-ventral gradient of dopamine release and uptake rate in mice, rats and rhesus macaques. Neurochem Int. 2012;61(7):986-991.

Ferris MJ, Mateo Y, Roberts DCS, Jones SR. Cocaine-insensitive dopamine transporters with intact substrate transport produced by self-administration. Biol Psychiatry. 2011;69(3):201-207.

Espana RA, Melchior JR, Roberts DCS, Jones SR. Hypocretin 1/orexin A in the ventral tegmental area enhances dopamine responses to cocaine and promotes cocaine self-administration. Psychopharmacology (Berl). 2011;214(2):415-426.



Hansen DM, Wilcox JD, Yorgason JT, Jones SR, Steffensen SC. Effects of D2 type autoreceptor antagonists on ethanol-induced modulation of dopamine release in the nucleus accumbens [abstract]. Alcohol Clin Exp Res. 2011;35(6 Suppl):65A.

Huggins KN, Locke JL, Konstantopoulos JK, Jones SR. Chronic intermittent ethanol induces kappa opioid receptor supersensitivity and reverses dopamine response to acute challenge [abstract]. Alcohol Clin Exp Res. 2011;35(6 Suppl):66A.

Espana RA, Oleson EB, Locke JL, Brookshire BR, Roberts DCS, Jones SR. The hypocretin-orexin system regulates cocaine self-administration via actions on the mesolimbic dopamine system. Eur J Neurosci. 2010;31(2):336-348.

Jones SR. Chronic alcohol exposure in monkeys, rats and mice reduces dopamine signaling in striatum [abstract]. Alcohol Clin Exp Res. 2010;34(6 Suppl 2):256A.

Carter ES, Chappell AM, Jones SR, Weiner JL. Effect of oral adolescent methylphenidate treatment and withdrawal on ethanol drinking and locomotor response to psychostimulants [abstract]. Alcohol Clin Exp Res. 2009;33(6 Special Issue):98A.

Mathews TA, Locke J, Friedman DP, Jones SR. Dopamine and serotonin neurochemistry in long-term alcohol drinking nursery and mother reared monkeys [abstract]. Alcohol Clin Exp Res. 2009;33(6 Special Issue):23A.


Mathews TA, Brookshire BR, Budygin EA, Hamre K, Goldowitz D, Jones SR. Ethanol-induced hyperactivity is associated with hypodopaminergia in the 22-TNJ ENU-mutated mouse. Alcohol. 2009;43(6):421-431.

Oleson EB, Salek J, Bonin KD, Jones SR, Budygin EA. Real-time voltammetric detection of cocaine-induced dopamine changes in the striatum of freely moving mice. Neurosci Lett. 2009;467(2):144-146.


Chappell AM, Jones SR, Weiner JL. Effect of adolescent methylphenidate treatment on ethanol self-administration in male Long-Evans rats [abstract]. Alcohol Clin Exp Res. 2008;32(6 Suppl 1):220A.


Mathews TA, Brookshire BR, Budygin EA, Daunais JB, Friedman DP, Jones SR. A neurochemical comparison of striatal dopamine function in drinking monkeys [abstract]. Alcohol Clin Exp Res. 2008;32(6 Suppl 1):35A.

Mathews TA, Locke J, Jones SR. Chronic ethanol vapor exposure downregulates presynaptic dopamine function in the nucleus accumbens of mice [abstract]. Alcohol Clin Exp Res. 2008;32(6 Suppl 1):157A.

Schroeder FA, Penta KL, Matevossian A, Jones SR, Konradi C, Tapper AR, Akbarian S. Drug-induced activation of dopamine D-1 receptor signaling and inhibition of class I/II histone deacetylase induce chromatin remodeling in reward circuitry and modulate cocaine-related behaviors. Neuropsychopharmacology. 2008;33(12):2981-2992.


Budygin EA, Oleson EB, Mathews TA, Lack AK, Diaz M, McCool BA, Jones SR. Terminal effects of chronic alcohol exposure on dopamine dynamics in rat striatum [abstract]. Alcohol Clin Exp Res. 2007;31(6 Suppl):83A.

John CE, Jones SR. Fast scan cyclic voltammetry of dopamine and serotonin in mouse brain slices In: Michael AC, Borland LM, eds. Electrochemical methods for neuroscience. Boca Raton (FL): CRC Press;2007: 49-62.

Budygin EA, Oleson EB, Mathews TA, Lack AK, Diaz MR, McCool BA, Jones SR. Effects of chronic alcohol exposure on dopamine uptake in rat nucleus accumbens and caudate putamen. Psychopharmacology (Berl). 2007;193(4):495-501.

Mathews TA, John CE, Lapa GB, Budygin EA, Jones SR. No role of the dopamine transporter in acute ethanol effects on striatal dopamine dynamics. Synapse. 2006;60(4):288-294.

Brookshire BR, Lapa A, Mathews TA, Jones SR. Cocaine and ethanol effects on nucleus accumbens dopamine in 22-TNJ mutant mice [abstract]. Alcohol Clin Exp Res. 2006;30(6 Suppl):181A.

Budygin EA, Jones SR. Accumbal dopamine release, but not uptake or synthesis, is altered by low and moderate doses of acute ethanol [abstract]. Alcohol Clin Exp Res. 2006;30(6 Suppl):182A.


Nordskog BK, Alexander GM, Hammarback JA, Mathews TA, Jones SR, Fisher TL, Godwin DW. Alterations in the molecular physiology of T-type calcium channels during ethanol withdrawal [abstract]. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.

John CE, Budygin EA, Weiner JL, Jones SR. NMDA receptor deficient mice display altered synaptic function and reward related behaviors [abstract]. Neuropsychopharmacology. 2006;31(Suppl):S76.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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