Sara Jones, Ph.D.Wake Forest School of Medicine

Sara Jones, Ph.D.


Contact Information

Academic: 336-716-8355 | Department: 336-716-8533


Related Links

Education & Training

  • B.S., University of Georgia, 1987
  • Ph.D., University of North Carolina-Chapel Hill, 1994


  • Research Society On Alcoholism
  • Society for Neuroscience
  • Assn Of Women In Science
Sara Jones, Ph.D.

Sara Jones, Ph.D.

Professor, Physiology & Pharmacology

Research Interests

drugs/therapeutic agents pharm, mental disorders/psychiatry/ps, neurosciences/behavior, substance abuse

Contact Information

Academic: 336-716-8355 | Department: 336-716-8533


Related Links

Recent Publications

Cervera-Juanes R, Wilhem LJ, Park B, Lee R, Locke J, Helms C, Gonzales S, Wand G, Jones SR, Grant KA, Ferguson B. MAOA expression predicts vulnerability for alcohol use. Mol Psychiatry. 2016;21(4):472-479.

Siciliano CA, Calipari ES, Yorgason JT, Mateo Y, Helms CM, Lovinger DM, Grant KA, Jones SR. Chronic ethanol self-administration in macaques shifts dopamine feedback inhibition to predominantly D2 receptors in nucleus accumbens core. Drug Alcohol Depend. 2016;158():159-163.

Rose JH, Karkhanis AN, Chen R, Gioia D, Lopez MF, Becker HC, McCool BA, Jones SR. Supersensitive kappa opioid receptors promotes ethanol withdrawal-related behaviors and reduce dopamine signaling in the nucleus accumbens. Int J Neuropsychopharmacol. 2016;19(5):.

Karkhanis AN, Rose JH, Weiner JL, Jones SR. Early-life social isolation stress increases kappa opioid receptor responsiveness and downregulates the dopamine system. Neuropsychopharmacology. 2016;41(9):2263-2274.

Siciliano CA, Calipari ES, Yorgason JT, Lovinger DM, Mateo Y, Jimenez VA, Helms CM, Grant KA, Jones SR. Increased presynaptic regulation of dopamine neurotransmission in the nucleus accumbens core following chronic ethanol self-administration in female macaques. Psychopharmacology (Berl). 2016;233(8):1435-1443.

Silverstein-Metzler MG, Shively CA, Clarkson TB [deceased], Appt SE, Carr JJ, Kritchevsky SB, Jones SR, Register TC. Sertraline inhibits increases in body fat and carbohydrate dysregulation in adult female cynomolgus monkeys. Psychoneuroendocrinology. 2016;68():29-38.

Shively CA, Fimmel A, Jones S, Nader M. Dietary modification of physiological responses to chronic psychosocial stress: implications for the obesity epidemic In: Shively CA, Wilson ME, eds. Social inequalities in health in nonhuman primates: the biology of the gradient. Switzerland: Springer;2016: 159-178.

Martin T, Kim S, Rose J, Jones S, Aube J, Bohn L. A novel G-protein biased kappa opioid that displays analgesic but not dysphoric actions in the rat [abstract]. J Pain. 2016;17(4 Suppl 1):S65.

Salvatore MF, Calipari ES, Jones SR. Regulation of tyrosine hydroxylase expression and phosphorylation in dopamine transporter-deficient mice. ACS Chem Neurosci. 2016;():.

Butler TR, Karkhanis AN, Jones SR, Weiner JL. Adolescent social isolation as a model of heightened vulnerability to comorbid alcoholism and anxiety disorders. Alcohol Clin Exp Res. 2016;40(6):1202-1214.

Fordahl SC, Locke JL, Jones SR. High fat diet augments amphetamine sensitization in mice: Role of feeding pattern, obesity, and dopamine terminal changes. Neuropharmacology. 2016;109():170-182.

Calipari ES, Siciliano CA, Zimmer BA, Jones SR. Brief intermittent cocaine self-administration and abstinence sensitizes cocaine effects on the dopamine transporter and increases drug seeking. Neuropsychopharmacology. 2015;40(3):728-735.

Luderman KD, Chen R, Ferris MJ, Jones SR, Gnegy ME. Protein kinase C beta regulates the D2-like dopamine autoreceptor. Neuropharmacology. 2015;89():335-341.

Yorgason JT, Rose JH, McIntosh JM, Ferris MJ, Jones SR. Greater ethanol inhibition of presynaptic dopamine release in C57BL/6J than DBA/2J mice: role of nicotinic acetylcholine receptors. Neuroscience. 2015;284():854-864.

Calipari ES, Ferris MJ, Siciliano CA, Jones SR. Differential influence of dopamine transport rate on the potencies of cocaine, amphetamine, and methylphenidate. ACS Chem Neurosci. 2015;6(1):155-162.

Siciliano CA, Calipari ES, Ferris MJ, Jones SR. Adaptations of presynaptic dopamine terminals induced by psychostimulant self-administration. ACS Chem Neurosci. 2015;6(1):27-36.

Ferris MJ, Calipari ES, Rose JH, Siciliano CA, Sun H, Chen R, Jones SR. A single amphetamine infusion reverses deficits in dopamine nerve-terminal function caused by a history of cocaine self-administration. Neuropsychopharmacology. 2015;40(8):1826-1836.

Richardson JR, Taylor MM, Shalat SL, Guillot TS III, Caudle WM, Hossain MM, Mathews TA, Jones SR, Cory-Slechta DA, Miller GW. Developmental pesticide exposure reproduces features of attention deficit hyperactivity disorder. FASEB J. 2015;29(5):1960-1972.

Karkhanis AN, Rose JH, Huggins KN, Konstantopoulos JK, Jones SR. Chronic intermittent ethanol exposure reduces presynaptic dopamine neurotransmission in the mouse nucleus accumbens. Drug Alcohol Depend. 2015;150():24-30.

Siciliano CA, Calipari ES, Cuzon Carlson VC, Helms CM, Lovinger DM, Grant KA, Jones SR. Voluntary ethanol intake predicts kappa-opioid receptor supersensitivity and regionally distinct dopaminergic adaptations in macaques. J Neurosci. 2015;35(15):5959-5968.

Karkhanis AN, Alexander NJ, McCool BA, Weiner JL, Jones SR. Chronic social isolation during adolescence augments catecholamine response to acute ethanol in the basolateral amygdala. Synapse. 2015;69(8):385-395.

Willard SL, Uberseder B, Clark A, Daunais JB, Johnston WD, Neely D, Massey A, Williamson JD, Kraft RA, Bourland JD, Jones SR, Shively CA. Long term sertraline effects on neural structures in depressed and nondepressed adult female nonhuman primates. Neuropharmacology. 2015;99():369-378.

Melchior JR, Ferris MJ, Stuber GD, Riddle DR, Jones SR. Optogenetic versus electrical stimulation of dopamine terminals in the nucleus accumbens reveals local modulation of presynaptic release. J Neurochem. 2015;134(5):833-844.

Siciliano CA, Ferris MJ, Jones SR. Cocaine self-administration disrupts mesolimbic dopamine circuit function and attenuates dopaminergic responsiveness to cocaine. Eur J Neurosci. 2015;42(4):2091-2096.

Pleil KE, Lowery-Gionta EG, Crowley NA, Li C, Marcinkiewcz CA, Rose JH, McCall NM, Maldonado-Devincci AM, Morrow AL, Jones SR, Kash TL. Effects of chronic ethanol exposure on neuronal function in the prefrontal cortex and extended amygdala. Neuropharmacology. 2015;99():735-749.

Sun H, Calipari ES, Beveridge TJ, Jones SR, Chen R. The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration. Neuroscience. 2015;307():253-261.

Siciliano C, Calipari E, Jones S. More than replacement therapy: amphetamine treatment rescues the behavioral and neurochemical consequences of cocaine [abstract]. J Neurochem. 2015;134(Suppl 1):217.

Cervera-Juanes R, Wilhem L, Park B, Lee R, Locke J, Helms C, Gonzales S, Wand G, Jones SR, Grant KA, Ferguson B. MAOA expression predicts vulnerability for alcohol use [abstract]. Alcohol Alcohol. 2015;50(Suppl 1):P-08.

Siciliano CA, Calipari ES, Carlson VCC, Helms CM, Lovinger DM, Grant KA, Jones SR. Voluntary ethanol intake predicts kappa opioid receptor supersensitivity and regionally distinct dopamingeric adaptations in macaques [abstract]. Alcohol Clin Exp Res. 2015;39(Suppl 1):180A.

Karkhanis AN, Rose JH, Weiner JL, Jones SR. Social isolation stress increases K-opioid receptor activity in the nucleus accumbens shell and core [abstract]. Alcohol Clin Exp Res. 2015;39(Suppl 1):121A.

Weiner JL, Karkhanis AN, Rau A, Skelly MJ, Jones SR. Adolescent social isolation as a model of alcohol addiction vulnerability [abstract]. Alcohol Alcohol. 2015;50(Suppl 1):SY17-2.

Yorgason JT, Calipari ES, Ferris MJ, Karkhanis AN, Fordahl SC, Weiner JL, Jones SR. Social isolation rearing increases dopamine uptake and psychostimulant potency in the striatum. Neuropharmacology. 2015;101():471-479.

Siciliano C, Gabriele A, Jones S, Ferris M. Dissociating appetitive and consummatory behavior in drug use prone and resistant animals [abstract]. Neuropsychopharmacology. 2015;40(Suppl 1):S251-S252.

Siciliano C, Calipari E, Fordahl S, Melchior J, Yorgason J, Mateo Y, Helms C, Lovinger D, Grant K, Jones S. Impact of chronic ethanol self-administration on kappa opioid receptor regulation of dopamine signaling in nonhuman primates [abstract]. Neuropsychopharmacology. 2015;40(Suppl 1):S267-S268.

Calipari ES, Ferris MJ, Melchior JR, Bermejo K, Salahpour A, Roberts DC, Jones SR. Methylphenidate and cocaine self-administration produce distinct dopamine terminal alterations. Addict Biol. 2014;19(2):145-155.

Yorgason JT, Ferris MJ, Steffensen SC, Jones SR. Frequency-dependent effects of ethanol on dopamine release in the nucleus accumbens. Alcohol Clin Exp Res. 2014;38(2):438-447.

Calipari ES, Ferris MJ, Jones SR. Extended access of cocaine self-administration results in tolerance to the dopamine-elevating and locomotor-stimulating effects of cocaine. J Neurochem. 2014;128(2):224-232.

Calipari ES, Ferris MJ, Siciliano CA, Zimmer BA, Jones SR. Intermittent cocaine self-administration produces sensitization of stimulant effects at the dopamine transporter. J Pharmacol Exp Ther. 2014;349(2):192-198.

Karkhanis A, Skelly MJ, Rau A, Yorgason J, Chappell A, Carter E, Jones S, McCool B, Weiner J. Early life stress increases behavioral and neurobiological risk factors of alcohol addiction in male Long Evans rats [abstract]. Alcohol. 2014;48(2):161.

Siciliano CA, Calipari ES, Ferris MJ, Jones SR. Biphasic mechanisms of amphetamine action at the dopamine terminal. J Neurosci. 2014;34(16):5575-5582.

Daigle TL, Ferris MJ, Gainetdinov RR, Sotnikova TD, Urs NM, Jones SR, Caron MG. Selective deletion of GRK2 alters psychostimulant-induced behaviors and dopamine neurotransmission. Neuropsychopharmacology. 2014;39(10):2450-2462.

Diaz MR, Jotty K, Locke JL, Jones SR, Valenzuela CF. Moderate alcohol exposure during the rat equivalent to the third trimester of human pregnancy alters regulation of GABAA receptor-mediated synaptic transmission by dopamine in the basolateral amygdala. Front Pediatr. 2014;2():46.

Calipari ES, Sun H, Eldeeb K, Luessen DJ, Feng X, Howlett AC, Jones SR, Chen R. Amphetamine self-administration attenuates dopamine D2 autoreceptor function. Neuropsychopharmacology. 2014;39(8):1833-1842.

Calipari ES, Jones SR. Sensitized nucleus accumbens dopamine terminal responses to methylphenidate and dopamine transporter releasers after intermittent-access self-administration. Neuropharmacology. 2014;82():1-10.

Ferris MJ, Espana RA, Locke JL, Konstantopoulos JK, Rose JH, Chen R, Jones SR. Dopamine transporters govern diurnal variation in extracellular dopamine tone. Proc Natl Acad Sci U S A. 2014;111(26):E2751-2759.

Siciliano CA, Calipari ES, Jones SR. Amphetamine potency varies with dopamine uptake rate across striatal subregions. J Neurochem. 2014;131(3):348-355.

Karkhanis AN, McCool BA, Weiner JL, Jones SR. Social isolation stress augments dopamine and norepinephrine responses to ethanol in the nucleus accumbens and the basolateral amygdala [abstract]. Alcohol Clin Exp Res. 2014;38(Suppl 1):81A.

Melchior JR, Jones SR. Optogenetic insights into ethanol effects on presynaptic dopamine terminal dynamics [abstract]. Alcohol Clin Exp Res. 2014;38(Suppl 1):82A.

Ferris MJ, Milenkovic M, Liu S, Mielnik CA, Beerepoot P, John CE, Espana RA, Sotnikova TD, Gainetdinov RR, Borgland SL, Jones SR, Ramsey AJ. Sustained N-methyl-D-aspartate receptor hypofunction remodels the dopamine system and impairs phasic signaling. Eur J Neurosci. 2014;40(1):2255-2263.

Karkhanis AN, Locke JL, McCool BA, Weiner JL, Jones SR. Social isolation rearing increases nucleus accumbens dopamine and norepinephrine responses to acute ethanol in adulthood. Alcohol Clin Exp Res. 2014;38(11):2770-2779.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Sara Jones, Ph.D.

Sara Jones, Ph.D.

Professor, Physiology & Pharmacology

Quick Reference

Request an Appointment
New Patients


Existing patients may contact the clinic directly.
Find a Doctor Ways to Give
USNWR 2015-2016Magnet Hospital RecognitionConsumer Choice2015 Best DoctorsJoint Commission Report

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.