Sara Jones, Ph.D.Wake Forest School of Medicine

Sara Jones, Ph.D.


Contact Information

Academic: 336-716-8355 | Department: 336-716-8533


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Education & Training

  • B.S., University of Georgia, 1987
  • Ph.D., University of North Carolina-Chapel Hill, 1994


  • Research Society On Alcoholism
  • Society for Neuroscience
  • Assn Of Women In Science
Sara Jones, Ph.D.

Sara Jones, Ph.D.

Professor, Physiology & Pharmacology

Research Interests

Dopamine; Cocaine; Dopamine Plasma Membrane Transport Proteins; Self Administration; Ventral Tegmental Area
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Contact Information

Academic: 336-716-8355 | Department: 336-716-8533


Related Links

Recent Publications

MAOA expression predicts vulnerability for alcohol use. Cervera-Juanes R, Wilhem LJ, Park B, Lee R, Locke J, Helms C, Gonzales S, Wand G, Jones SR, Grant KA, Ferguson B.. Mol Psychiatry. 2016;21(4):472-479.

Chronic ethanol self-administration in macaques shifts dopamine feedback inhibition to predominantly D2 receptors in nucleus accumbens core. Siciliano CA, Calipari ES, Yorgason JT, Mateo Y, Helms CM, Lovinger DM, Grant KA, Jones SR.. Drug Alcohol Depend. 2016;158():159-163.

Supersensitive kappa opioid receptors promotes ethanol withdrawal-related behaviors and reduce dopamine signaling in the nucleus accumbens. Rose JH, Karkhanis AN, Chen R, Gioia D, Lopez MF, Becker HC, McCool BA, Jones SR.. Int J Neuropsychopharmacol. 2016;19(5):.

Early-life social isolation stress increases kappa opioid receptor responsiveness and downregulates the dopamine system. Karkhanis AN, Rose JH, Weiner JL, Jones SR.. Neuropsychopharmacology. 2016;41(9):2263-2274.

Increased presynaptic regulation of dopamine neurotransmission in the nucleus accumbens core following chronic ethanol self-administration in female macaques. Siciliano CA, Calipari ES, Yorgason JT, Lovinger DM, Mateo Y, Jimenez VA, Helms CM, Grant KA, Jones SR.. Psychopharmacology (Berl). 2016;233(8):1435-1443.

Sertraline inhibits increases in body fat and carbohydrate dysregulation in adult female cynomolgus monkeys. Silverstein-Metzler MG, Shively CA, Clarkson TB [deceased], Appt SE, Carr JJ, Kritchevsky SB, Jones SR, Register TC.. Psychoneuroendocrinology. 2016;68():29-38.

Dietary modification of physiological responses to chronic psychosocial stress: implications for the obesity epidemic. Shively CA, Fimmel A, Jones S, Nader M. In: Shively CA, Wilson ME, eds. Social inequalities in health in nonhuman primates: the biology of the gradient. Switzerland: Springer;2016: 159-178.

A novel G-protein biased kappa opioid that displays analgesic but not dysphoric actions in the rat [abstract]. Martin T, Kim S, Rose J, Jones S, Aube J, Bohn L.. J Pain. 2016;17(4 Suppl 1):S65.

Regulation of tyrosine hydroxylase expression and phosphorylation in dopamine transporter-deficient mice. Salvatore MF, Calipari ES, Jones SR.. ACS Chem Neurosci. 2016;7(7):941-951.

Adolescent social isolation as a model of heightened vulnerability to comorbid alcoholism and anxiety disorders. Butler TR, Karkhanis AN, Jones SR, Weiner JL.. Alcohol Clin Exp Res. 2016;40(6):1202-1214.

High fat diet augments amphetamine sensitization in mice: Role of feeding pattern, obesity, and dopamine terminal changes. Fordahl SC, Locke JL, Jones SR.. Neuropharmacology. 2016;109():170-182.

The individual and combined effects of phenmetrazine and mgluR2/3 agonist LY379268 on the motivation to self-administer cocaine. Karkhanis AN, Beveridge TJ, Blough BE, Jones SR, Ferris MJ.. Drug Alcohol Depend. 2016;166():51-60.

Dopamine D3 autoreceptor inhibition enhances cocaine potency at the dopamine transporter. McGinnis MM, Siciliano CA, Jones SR.. J Neurochem. 2016;():.

Brief intermittent cocaine self-administration and abstinence sensitizes cocaine effects on the dopamine transporter and increases drug seeking. Calipari ES, Siciliano CA, Zimmer BA, Jones SR.. Neuropsychopharmacology. 2015;40(3):728-735.

Protein kinase C beta regulates the D2-like dopamine autoreceptor. Luderman KD, Chen R, Ferris MJ, Jones SR, Gnegy ME.. Neuropharmacology. 2015;89():335-341.

Greater ethanol inhibition of presynaptic dopamine release in C57BL/6J than DBA/2J mice: role of nicotinic acetylcholine receptors. Yorgason JT, Rose JH, McIntosh JM, Ferris MJ, Jones SR.. Neuroscience. 2015;284():854-864.

Differential influence of dopamine transport rate on the potencies of cocaine, amphetamine, and methylphenidate. Calipari ES, Ferris MJ, Siciliano CA, Jones SR.. ACS Chem Neurosci. 2015;6(1):155-162.

Adaptations of presynaptic dopamine terminals induced by psychostimulant self-administration. Siciliano CA, Calipari ES, Ferris MJ, Jones SR.. ACS Chem Neurosci. 2015;6(1):27-36.

A single amphetamine infusion reverses deficits in dopamine nerve-terminal function caused by a history of cocaine self-administration. Ferris MJ, Calipari ES, Rose JH, Siciliano CA, Sun H, Chen R, Jones SR.. Neuropsychopharmacology. 2015;40(8):1826-1836.

Developmental pesticide exposure reproduces features of attention deficit hyperactivity disorder. Richardson JR, Taylor MM, Shalat SL, Guillot TS III, Caudle WM, Hossain MM, Mathews TA, Jones SR, Cory-Slechta DA, Miller GW.. FASEB J. 2015;29(5):1960-1972.

Chronic intermittent ethanol exposure reduces presynaptic dopamine neurotransmission in the mouse nucleus accumbens. Karkhanis AN, Rose JH, Huggins KN, Konstantopoulos JK, Jones SR.. Drug Alcohol Depend. 2015;150():24-30.

Voluntary ethanol intake predicts kappa-opioid receptor supersensitivity and regionally distinct dopaminergic adaptations in macaques. Siciliano CA, Calipari ES, Cuzon Carlson VC, Helms CM, Lovinger DM, Grant KA, Jones SR.. J Neurosci. 2015;35(15):5959-5968.

Chronic social isolation during adolescence augments catecholamine response to acute ethanol in the basolateral amygdala. Karkhanis AN, Alexander NJ, McCool BA, Weiner JL, Jones SR.. Synapse. 2015;69(8):385-395.

Long term sertraline effects on neural structures in depressed and nondepressed adult female nonhuman primates. Willard SL, Uberseder B, Clark A, Daunais JB, Johnston WD, Neely D, Massey A, Williamson JD, Kraft RA, Bourland JD, Jones SR, Shively CA.. Neuropharmacology. 2015;99():369-378.

Optogenetic versus electrical stimulation of dopamine terminals in the nucleus accumbens reveals local modulation of presynaptic release. Melchior JR, Ferris MJ, Stuber GD, Riddle DR, Jones SR.. J Neurochem. 2015;134(5):833-844.

Cocaine self-administration disrupts mesolimbic dopamine circuit function and attenuates dopaminergic responsiveness to cocaine. Siciliano CA, Ferris MJ, Jones SR.. Eur J Neurosci. 2015;42(4):2091-2096.

Effects of chronic ethanol exposure on neuronal function in the prefrontal cortex and extended amygdala. Pleil KE, Lowery-Gionta EG, Crowley NA, Li C, Marcinkiewcz CA, Rose JH, McCall NM, Maldonado-Devincci AM, Morrow AL, Jones SR, Kash TL.. Neuropharmacology. 2015;99():735-749.

The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration. Sun H, Calipari ES, Beveridge TJ, Jones SR, Chen R.. Neuroscience. 2015;307():253-261.

More than replacement therapy: amphetamine treatment rescues the behavioral and neurochemical consequences of cocaine [abstract]. Siciliano C, Calipari E, Jones S.. J Neurochem. 2015;134(Suppl 1):217.

MAOA expression predicts vulnerability for alcohol use [abstract]. Cervera-Juanes R, Wilhem L, Park B, Lee R, Locke J, Helms C, Gonzales S, Wand G, Jones SR, Grant KA, Ferguson B.. Alcohol Alcohol. 2015;50(Suppl 1):P-08.

Voluntary ethanol intake predicts kappa opioid receptor supersensitivity and regionally distinct dopamingeric adaptations in macaques [abstract]. Siciliano CA, Calipari ES, Carlson VCC, Helms CM, Lovinger DM, Grant KA, Jones SR.. Alcohol Clin Exp Res. 2015;39(Suppl 1):180A.

Social isolation stress increases K-opioid receptor activity in the nucleus accumbens shell and core [abstract]. Karkhanis AN, Rose JH, Weiner JL, Jones SR.. Alcohol Clin Exp Res. 2015;39(Suppl 1):121A.

Adolescent social isolation as a model of alcohol addiction vulnerability [abstract]. Weiner JL, Karkhanis AN, Rau A, Skelly MJ, Jones SR.. Alcohol Alcohol. 2015;50(Suppl 1):SY17-2.

Social isolation rearing increases dopamine uptake and psychostimulant potency in the striatum. Yorgason JT, Calipari ES, Ferris MJ, Karkhanis AN, Fordahl SC, Weiner JL, Jones SR.. Neuropharmacology. 2015;101():471-479.

Dissociating appetitive and consummatory behavior in drug use prone and resistant animals [abstract]. Siciliano C, Gabriele A, Jones S, Ferris M.. Neuropsychopharmacology. 2015;40(Suppl 1):S251-S252.

Impact of chronic ethanol self-administration on kappa opioid receptor regulation of dopamine signaling in nonhuman primates [abstract]. Siciliano C, Calipari E, Fordahl S, Melchior J, Yorgason J, Mateo Y, Helms C, Lovinger D, Grant K, Jones S.. Neuropsychopharmacology. 2015;40(Suppl 1):S267-S268.

Methylphenidate and cocaine self-administration produce distinct dopamine terminal alterations. Calipari ES, Ferris MJ, Melchior JR, Bermejo K, Salahpour A, Roberts DC, Jones SR.. Addict Biol. 2014;19(2):145-155.

Frequency-dependent effects of ethanol on dopamine release in the nucleus accumbens. Yorgason JT, Ferris MJ, Steffensen SC, Jones SR.. Alcohol Clin Exp Res. 2014;38(2):438-447.

Extended access of cocaine self-administration results in tolerance to the dopamine-elevating and locomotor-stimulating effects of cocaine. Calipari ES, Ferris MJ, Jones SR.. J Neurochem. 2014;128(2):224-232.

Intermittent cocaine self-administration produces sensitization of stimulant effects at the dopamine transporter. Calipari ES, Ferris MJ, Siciliano CA, Zimmer BA, Jones SR.. J Pharmacol Exp Ther. 2014;349(2):192-198.

Early life stress increases behavioral and neurobiological risk factors of alcohol addiction in male Long Evans rats [abstract]. Karkhanis A, Skelly MJ, Rau A, Yorgason J, Chappell A, Carter E, Jones S, McCool B, Weiner J.. Alcohol. 2014;48(2):161.

Biphasic mechanisms of amphetamine action at the dopamine terminal. Siciliano CA, Calipari ES, Ferris MJ, Jones SR.. J Neurosci. 2014;34(16):5575-5582.

Selective deletion of GRK2 alters psychostimulant-induced behaviors and dopamine neurotransmission. Daigle TL, Ferris MJ, Gainetdinov RR, Sotnikova TD, Urs NM, Jones SR, Caron MG.. Neuropsychopharmacology. 2014;39(10):2450-2462.

Moderate alcohol exposure during the rat equivalent to the third trimester of human pregnancy alters regulation of GABAA receptor-mediated synaptic transmission by dopamine in the basolateral amygdala. Diaz MR, Jotty K, Locke JL, Jones SR, Valenzuela CF.. Front Pediatr. 2014;2():46.

Amphetamine self-administration attenuates dopamine D2 autoreceptor function. Calipari ES, Sun H, Eldeeb K, Luessen DJ, Feng X, Howlett AC, Jones SR, Chen R.. Neuropsychopharmacology. 2014;39(8):1833-1842.

Sensitized nucleus accumbens dopamine terminal responses to methylphenidate and dopamine transporter releasers after intermittent-access self-administration. Calipari ES, Jones SR.. Neuropharmacology. 2014;82():1-10.

Dopamine transporters govern diurnal variation in extracellular dopamine tone. Ferris MJ, Espana RA, Locke JL, Konstantopoulos JK, Rose JH, Chen R, Jones SR.. Proc Natl Acad Sci U S A. 2014;111(26):E2751-2759.

Amphetamine potency varies with dopamine uptake rate across striatal subregions. Siciliano CA, Calipari ES, Jones SR.. J Neurochem. 2014;131(3):348-355.

Social isolation stress augments dopamine and norepinephrine responses to ethanol in the nucleus accumbens and the basolateral amygdala [abstract]. Karkhanis AN, McCool BA, Weiner JL, Jones SR.. Alcohol Clin Exp Res. 2014;38(Suppl 1):81A.

Optogenetic insights into ethanol effects on presynaptic dopamine terminal dynamics [abstract]. Melchior JR, Jones SR.. Alcohol Clin Exp Res. 2014;38(Suppl 1):82A.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Sara Jones, Ph.D.

Sara Jones, Ph.D.

Professor, Physiology & Pharmacology

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