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Sara Jones, Ph.D.Wake Forest School of Medicine

Sara Jones, Ph.D.

Substance Addiction& Abuse Ctr

Contact Information

Academic: 336-716-8355 | Department: 336-716-8533


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Education & Training

  • B.S., University of Georgia, 1987
  • Ph.D., University of North Carolina-Chapel Hill, 1994


  • Research Society On Alcoholism
  • Society for Neuroscience
  • Assn Of Women In Science
Sara Jones, Ph.D.

Sara Jones, Ph.D.

Professor, Physiology & Pharmacology
Substance Addiction& Abuse Ctr
Institute for Regenerative Medicine

Research Interests

Dopamine; Nucleus Accumbens; Dopamine Plasma Membrane Transport Proteins; Cocaine; Ethanol
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Contact Information

Academic: 336-716-8355 | Department: 336-716-8533


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Recent Publications

Dopamine synthesis in alcohol drinking-prone and -resistant mouse strains. Siciliano CA, Locke JL, Mathews TA, Lopez MF, Becker HC, Jones SR.. Alcohol. 2017;58():25-32.

Reinforcing doses of intravenous cocaine produce only modest dopamine uptake inhibition. Brodnik ZD, Ferris MJ, Jones SR, Espana RA.. ACS Chem Neurosci. 2017;8(2):281-289.

Cocaine potency at the dopamine transporter tracks discrete motivational states during cocaine self-administration. Siciliano CA, Jones SR.. Neuropsychopharmacology. 2017;42(9):1893-1904.

High-fat-diet-induced deficits in dopamine terminal function are reversed by restoring insulin signaling. Fordahl SC, Jones SR.. ACS Chem Neurosci. 2017;8(2):290-299.

Social isolation stress increases KAPPA opioid receptor function on dopamine terminals in the nucleus accumbens of rats [abstract]. Karkhanis AN, Leussen D, Weiner JL, Chen R, Jones SR.. Alcohol. 2017;60():215.

Regulation of dopamine and dynorphin/KOR function by chronic ethanol and withdrawal in mice and monkeys [abstract]. Holleran KM, Karkhanis A, Rose JH, Siciliano CA, Grant KA, Jones SR.. Alcohol. 2017;60():220.

Increased negative affective behavior and disturbance of nucleus accumbens dopamine dynamics in mice following protracted withdrawal from CIE [abstract]. Holleran KM, Albertson SE, Jones SR.. Alcohol Clin Exp Res. 2017;41(Suppl 1):23A.

Chronic stress and ethanol-mediated alterations in norepineprhine transmission in mesolimbic circuitry [abstract]. Karkhanis AN, Jones SR.. Alcohol Clin Exp Res. 2017;41(Suppl 1):323A.

Chronic ethanol exposure increases inhibition of phasic dopamine release in the nucleus accumbens core and medial shell [abstract]. Melchior JR, Jones SR.. Alcohol Clin Exp Res. 2017;41(Suppl 1):21A.

alpha6beta2 subunit containing nicotinic acetylcholine receptors exert opposing actions on rapid dopamine signaling in the nucleus accumbens of rats with high-versus low-response to novelty. Siciliano CA, McIntosh JM, Jones SR, Ferris MJ.. Neuropharmacology. 2017;():.

Limited access to a palatable high fat diet promotes binge-like food intake and addiction-like dopamine terminal adaptations in the nucleus accumbens core of mice [abstract]. Fordahl S, Jones S.. FASEB J. 2017;31(Suppl 1):636.33.

A G protein-biased ligand of the kappa opioid receptor is antinociceptive and antipruritic but does not cause sedation or dysphoria [abstract]. Brust TF, Morgenweck J, Kim SA, Rose JH, Locke JL, Schmid CL, Zhou L, Stahl EL, Cameron MD, Scarry SM, Aube J, Jones SR, Martin TJ, Bohn LM.. FASEB J. 2017;31(Suppl 1):992.4.

Alterations in nucleus accumbens dopamine terminals following dopamine tolerance- or sensitization-inducing cocaine self-administration protocols [abstract]. Mauterer MI, Albertson SE, Jones SR.. FASEB J. 2017;31(Suppl 1):986.1.

Chronic ethanol exposure increases inhibition of optically targeted phasic dopamine release in the nucleus accumbens core and medial shell ex vivo. Melchior JR, Jones SR.. Mol Cell Neurosci. 2017;85():93-104.

MAOA expression predicts vulnerability for alcohol use. Cervera-Juanes R, Wilhem LJ, Park B, Lee R, Locke J, Helms C, Gonzales S, Wand G, Jones SR, Grant KA, Ferguson B.. Mol Psychiatry. 2016;21(4):472-479.

Chronic ethanol self-administration in macaques shifts dopamine feedback inhibition to predominantly D2 receptors in nucleus accumbens core. Siciliano CA, Calipari ES, Yorgason JT, Mateo Y, Helms CM, Lovinger DM, Grant KA, Jones SR.. Drug Alcohol Depend. 2016;158():159-163.

Supersensitive kappa opioid receptors promotes ethanol withdrawal-related behaviors and reduce dopamine signaling in the nucleus accumbens. Rose JH, Karkhanis AN, Chen R, Gioia D, Lopez MF, Becker HC, McCool BA, Jones SR.. Int J Neuropsychopharmacol. 2016;19(5):.

Early-life social isolation stress increases kappa opioid receptor responsiveness and downregulates the dopamine system. Karkhanis AN, Rose JH, Weiner JL, Jones SR.. Neuropsychopharmacology. 2016;41(9):2263-2274.

Increased presynaptic regulation of dopamine neurotransmission in the nucleus accumbens core following chronic ethanol self-administration in female macaques. Siciliano CA, Calipari ES, Yorgason JT, Lovinger DM, Mateo Y, Jimenez VA, Helms CM, Grant KA, Jones SR.. Psychopharmacology (Berl). 2016;233(8):1435-1443.

Sertraline inhibits increases in body fat and carbohydrate dysregulation in adult female cynomolgus monkeys. Silverstein-Metzler MG, Shively CA, Clarkson TB [deceased], Appt SE, Carr JJ, Kritchevsky SB, Jones SR, Register TC.. Psychoneuroendocrinology. 2016;68():29-38.

Dietary modification of physiological responses to chronic psychosocial stress: implications for the obesity epidemic. Shively CA, Fimmel A, Jones S, Nader M. In: Shively CA, Wilson ME, eds. Social inequalities in health in nonhuman primates: the biology of the gradient. Switzerland: Springer;2016: 159-178.

A novel G-protein biased kappa opioid that displays analgesic but not dysphoric actions in the rat [abstract]. Martin T, Kim S, Rose J, Jones S, Aube J, Bohn L.. J Pain. 2016;17(4 Suppl 1):S65.

Regulation of tyrosine hydroxylase expression and phosphorylation in dopamine transporter-deficient mice. Salvatore MF, Calipari ES, Jones SR.. ACS Chem Neurosci. 2016;7(7):941-951.

Adolescent social isolation as a model of heightened vulnerability to comorbid alcoholism and anxiety disorders. Butler TR, Karkhanis AN, Jones SR, Weiner JL.. Alcohol Clin Exp Res. 2016;40(6):1202-1214.

High fat diet augments amphetamine sensitization in mice: Role of feeding pattern, obesity, and dopamine terminal changes. Fordahl SC, Locke JL, Jones SR.. Neuropharmacology. 2016;109():170-182.

The individual and combined effects of phenmetrazine and mgluR2/3 agonist LY379268 on the motivation to self-administer cocaine. Karkhanis AN, Beveridge TJ, Blough BE, Jones SR, Ferris MJ.. Drug Alcohol Depend. 2016;166():51-60.

Dopamine D3 autoreceptor inhibition enhances cocaine potency at the dopamine transporter. McGinnis MM, Siciliano CA, Jones SR.. J Neurochem. 2016;138(6):821-829.

Switch from excitatory to inhibitory actions of ethanol on dopamine levels after chronic exposure: role of kappa opioid receptors. Karkhanis AN, Huggins KN, Rose JH, Jones SR.. Neuropharmacology. 2016;110(Pt A):190-197.

Distinct effects of nalmefene on dopamine uptake rates and kappa opioid receptor activity in the nucleus accumbens following chronic intermittent ethanol exposure. Rose JH, Karkhanis AN, Steiniger-Brach B, Jones SR.. Int J Mol Sci. 2016;17(8):1216.

Hypocretin/orexin knock-out mice display disrupted behavioral and dopamine responses to cocaine. Shaw JK, Ferris MJ, Locke JL, Brodnik ZD, Jones SR, Espana RA.. Addict Biol. 2016;():.

Cocaine self-administration produces long-lasting alterations in dopamine transporter responses to cocaine. Siciliano CA, Fordahl SC, Jones SR.. J Neurosci. 2016;36(30):7807-7816.

Impact of chronic ethanol self-administration on KAPPA opioid receptor regulation of dopamine signaling in nonhuman primates [abstract]. Siciliano CA, Calipari ES, Fordahl SC, Melchior JR, Yorgason JT, Mateo Y, Helms CM, Lovinger DM, Grant KA, Jones SR.. Alcohol Clin Exp Res. 2016;40(Suppl 1):198A.

Hyperactive KAPPA opioid receptors and increased presynaptic inhibitory regulation of dopamine after chronic alcohol exposure in mice and monkeys [abstract]. Siciliano CA, Rose JH, Fordahl SC, Karkhanis AN, Melchior JR, Jones SR.. Alcohol Clin Exp Res. 2016;40(Suppl 1):288A.

Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria. Brust TF, Morgenweck J, Kim SA, Rose JH, Locke JL, Schmid CL, Zhou L, Stahl EL, Cameron MD, Scarry SM, Aube J, Jones SR, Martin TJ, Bohn LM.. Sci Signal. 2016;9(456):ra117.

Brief intermittent cocaine self-administration and abstinence sensitizes cocaine effects on the dopamine transporter and increases drug seeking. Calipari ES, Siciliano CA, Zimmer BA, Jones SR.. Neuropsychopharmacology. 2015;40(3):728-735.

Protein kinase C beta regulates the D2-like dopamine autoreceptor. Luderman KD, Chen R, Ferris MJ, Jones SR, Gnegy ME.. Neuropharmacology. 2015;89():335-341.

Greater ethanol inhibition of presynaptic dopamine release in C57BL/6J than DBA/2J mice: role of nicotinic acetylcholine receptors. Yorgason JT, Rose JH, McIntosh JM, Ferris MJ, Jones SR.. Neuroscience. 2015;284():854-864.

Differential influence of dopamine transport rate on the potencies of cocaine, amphetamine, and methylphenidate. Calipari ES, Ferris MJ, Siciliano CA, Jones SR.. ACS Chem Neurosci. 2015;6(1):155-162.

Adaptations of presynaptic dopamine terminals induced by psychostimulant self-administration. Siciliano CA, Calipari ES, Ferris MJ, Jones SR.. ACS Chem Neurosci. 2015;6(1):27-36.

A single amphetamine infusion reverses deficits in dopamine nerve-terminal function caused by a history of cocaine self-administration. Ferris MJ, Calipari ES, Rose JH, Siciliano CA, Sun H, Chen R, Jones SR.. Neuropsychopharmacology. 2015;40(8):1826-1836.

Developmental pesticide exposure reproduces features of attention deficit hyperactivity disorder. Richardson JR, Taylor MM, Shalat SL, Guillot TS III, Caudle WM, Hossain MM, Mathews TA, Jones SR, Cory-Slechta DA, Miller GW.. FASEB J. 2015;29(5):1960-1972.

Chronic intermittent ethanol exposure reduces presynaptic dopamine neurotransmission in the mouse nucleus accumbens. Karkhanis AN, Rose JH, Huggins KN, Konstantopoulos JK, Jones SR.. Drug Alcohol Depend. 2015;150():24-30.

Voluntary ethanol intake predicts kappa-opioid receptor supersensitivity and regionally distinct dopaminergic adaptations in macaques. Siciliano CA, Calipari ES, Cuzon Carlson VC, Helms CM, Lovinger DM, Grant KA, Jones SR.. J Neurosci. 2015;35(15):5959-5968.

Chronic social isolation during adolescence augments catecholamine response to acute ethanol in the basolateral amygdala. Karkhanis AN, Alexander NJ, McCool BA, Weiner JL, Jones SR.. Synapse. 2015;69(8):385-395.

Long term sertraline effects on neural structures in depressed and nondepressed adult female nonhuman primates. Willard SL, Uberseder B, Clark A, Daunais JB, Johnston WD, Neely D, Massey A, Williamson JD, Kraft RA, Bourland JD, Jones SR, Shively CA.. Neuropharmacology. 2015;99():369-378.

Optogenetic versus electrical stimulation of dopamine terminals in the nucleus accumbens reveals local modulation of presynaptic release. Melchior JR, Ferris MJ, Stuber GD, Riddle DR, Jones SR.. J Neurochem. 2015;134(5):833-844.

Cocaine self-administration disrupts mesolimbic dopamine circuit function and attenuates dopaminergic responsiveness to cocaine. Siciliano CA, Ferris MJ, Jones SR.. Eur J Neurosci. 2015;42(4):2091-2096.

Effects of chronic ethanol exposure on neuronal function in the prefrontal cortex and extended amygdala. Pleil KE, Lowery-Gionta EG, Crowley NA, Li C, Marcinkiewcz CA, Rose JH, McCall NM, Maldonado-Devincci AM, Morrow AL, Jones SR, Kash TL.. Neuropharmacology. 2015;99():735-749.

The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration. Sun H, Calipari ES, Beveridge TJ, Jones SR, Chen R.. Neuroscience. 2015;307():253-261.

More than replacement therapy: amphetamine treatment rescues the behavioral and neurochemical consequences of cocaine [abstract]. Siciliano C, Calipari E, Jones S.. J Neurochem. 2015;134(Suppl 1):217.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Sara Jones, Ph.D.

Sara Jones, Ph.D.

Professor, Physiology & Pharmacology
Substance Addiction& Abuse Ctr
Institute for Regenerative Medicine

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