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Profile

Profile
Research

Sara Jones, Ph.D.

Professor, Physiology & Pharmacology
WFU Primate Center
Institute for Regenerative Medicine
Institute for Regenerative Medicine

Contact Information

Academic: 336-716-8355 | Department: 336-716-8533

Email: srjones@wakehealth.edu

Education & Training

Ph.D., University of North Carolina-Chapel Hill , 1994
B.S., University of Georgia , 1987

Memberships

Research Society On Alcoholism
Society for Neuroscience
Assn Of Women In Science

Sara Jones, Ph.D.

Professor, Physiology & Pharmacology WFU Primate Center
Institute for Regenerative Medicine
Institute for Regenerative Medicine

Research Interests

neurosciences/behavior, substance abuse

Contact Information

Academic: 336-716-8355 | Department: 336-716-8533

Email: srjones@wakehealth.edu

Recent Publications

Espana RA, Jones SR. Presynaptic dopamine modulation by stimulant self-administration. Front Biosci (Schol Ed). 2013;5():261-276.

Ferris MJ, Calipari ES, Mateo Y, Melchior JR, Roberts DCS, Jones SR. Cocaine self-administration produces pharmacodynamic tolerance: differential effects on the potency of dopamine transporter blockers, releasers, and methylphenidate. Neuropsychopharmacology. 2012;37(7):1708-1716.

Oleson EB, Ferris MJ, Espana RA, Harp J, Jones SR. Effects of the histamine H1 receptor antagonist and benztropine analog diphenylpyraline on dopamine uptake, locomotion and reward. Eur J Pharmacol. 2012;683(1-3):161-165.

Huggins KN, Mathews TA, Locke JL, Szeliga KT, Friedman DP, Bennett AJ, Jones SR. Effects of early life stress on drinking and serotonin system activity in rhesus macaques: 5-hydroxyindoleacetic acid in cerebrospinal fluid predicts brain tissue levels. Alcohol. 2012;46(4):371-376.

Brookshire BR, Jones SR. Chronic methylphenidate administration in mice produces depressive-like behaviors and altered responses to fluoxetine. Synapse. 2012;66(9):844-847.

Chappell AM, Carter E, Yorgason JT, Jones SR, McCool BA, Weiner JL. Juvenile social isolation in rats increases behavioral and neurobiological risk factors of alcoholism [abstract]. Alcohol Clin Exp Res. 2012;36(Suppl 2):51A.

Calipari ES, Huggins KN, Mathews TA, Jones SR. Conserved dorsal-ventral gradient of dopamine release and uptake rate in mice, rats and rhesus macaques. Neurochem Int. 2012;61(7):986-991.

Ferris MJ, Mateo Y, Roberts DCS, Jones SR. Cocaine-insensitive dopamine transporters with intact substrate transport produced by self-administration. Biol Psychiatry. 2011;69(3):201-207.

Espana RA, Melchior JR, Roberts DCS, Jones SR. Hypocretin 1/orexin A in the ventral tegmental area enhances dopamine responses to cocaine and promotes cocaine self-administration. Psychopharmacology (Berl). 2011;214(2):415-426.

Yorgason JT, Jones SR, Espana RA. Low and high affinity dopamine transporter inhibitors block dopamine uptake within 5 sec of intravenous injection. Neuroscience. 2011;182():125-132.

Yorgason JT, Espana RA, Jones SR. Demon voltammetry and analysis software: analysis of cocaine-induced alterations in dopamine signaling using multiple kinetic measures. J Neurosci Methods. 2011;202(2):158-164.

Hansen DM, Wilcox JD, Yorgason JT, Jones SR, Steffensen SC. Effects of D2 type autoreceptor antagonists on ethanol-induced modulation of dopamine release in the nucleus accumbens [abstract]. Alcohol Clin Exp Res. 2011;35(6 Suppl):65A.

Huggins KN, Locke JL, Konstantopoulos JK, Jones SR. Chronic intermittent ethanol induces kappa opioid receptor supersensitivity and reverses dopamine response to acute challenge [abstract]. Alcohol Clin Exp Res. 2011;35(6 Suppl):66A.

Espana RA, Oleson EB, Locke JL, Brookshire BR, Roberts DCS, Jones SR. The hypocretin-orexin system regulates cocaine self-administration via actions on the mesolimbic dopamine system. Eur J Neurosci. 2010;31(2):336-348.

Jones SR. Chronic alcohol exposure in monkeys, rats and mice reduces dopamine signaling in striatum [abstract]. Alcohol Clin Exp Res. 2010;34(6 Suppl 2):256A.

Carter ES, Chappell AM, Jones SR, Weiner JL. Effect of oral adolescent methylphenidate treatment and withdrawal on ethanol drinking and locomotor response to psychostimulants [abstract]. Alcohol Clin Exp Res. 2009;33(6 Special Issue):98A.

Mathews TA, Locke J, Friedman DP, Jones SR. Dopamine and serotonin neurochemistry in long-term alcohol drinking nursery and mother reared monkeys [abstract]. Alcohol Clin Exp Res. 2009;33(6 Special Issue):23A.

Brookshire BR, Jones SR. Direct and indirect 5-HT receptor agonists produce gender-specific effects on locomotor and vertical activities in C57 BL/6J mice. Pharmacol Biochem Behav. 2009;94(1):194-203.

Mathews TA, Brookshire BR, Budygin EA, Hamre K, Goldowitz D, Jones SR. Ethanol-induced hyperactivity is associated with hypodopaminergia in the 22-TNJ ENU-mutated mouse. Alcohol. 2009;43(6):421-431.

Oleson EB, Salek J, Bonin KD, Jones SR, Budygin EA. Real-time voltammetric detection of cocaine-induced dopamine changes in the striatum of freely moving mice. Neurosci Lett. 2009;467(2):144-146.

Lack CM, Jones SR, Roberts DCS. Increased breakpoints on a progressive ratio schedule reinforced by IV cocaine are associated with reduced locomotor activation and reduced dopamine efflux in nucleus accumbens shell in rats. Psychopharmacology (Berl). 2008;195(4):517-525.

Chappell AM, Jones SR, Weiner JL. Effect of adolescent methylphenidate treatment on ethanol self-administration in male Long-Evans rats [abstract]. Alcohol Clin Exp Res. 2008;32(6 Suppl 1):220A.

Espana RA, Roberts DCS, Jones SR. Short-acting cocaine and long-acting GBR-12909 both elicit rapid dopamine uptake inhibition following intravenous delivery. Neuroscience. 2008;155(1):250-257.

Mathews TA, Brookshire BR, Budygin EA, Daunais JB, Friedman DP, Jones SR. A neurochemical comparison of striatal dopamine function in drinking monkeys [abstract]. Alcohol Clin Exp Res. 2008;32(6 Suppl 1):35A.

Mathews TA, Locke J, Jones SR. Chronic ethanol vapor exposure downregulates presynaptic dopamine function in the nucleus accumbens of mice [abstract]. Alcohol Clin Exp Res. 2008;32(6 Suppl 1):157A.

Schroeder FA, Penta KL, Matevossian A, Jones SR, Konradi C, Tapper AR, Akbarian S. Drug-induced activation of dopamine D-1 receptor signaling and inhibition of class I/II histone deacetylase induce chromatin remodeling in reward circuitry and modulate cocaine-related behaviors. Neuropsychopharmacology. 2008;33(12):2981-2992.

John CE, Jones SR. Voltammetric characterization of the effect of monoamine uptake inhibitors and releasers on dopamine and serotonin uptake in mouse caudate-putamen and substantia nigra slices. Neuropharmacology. 2007;52(8):1596-1605.

Budygin EA, Oleson EB, Mathews TA, Lack AK, Diaz M, McCool BA, Jones SR. Terminal effects of chronic alcohol exposure on dopamine dynamics in rat striatum [abstract]. Alcohol Clin Exp Res. 2007;31(6 Suppl):83A.

John CE, Jones SR. Fast scan cyclic voltammetry of dopamine and serotonin in mouse brain slices In: Michael AC, Borland LM, eds. Electrochemical methods for neuroscience. Boca Raton (FL): CRC Press;2007: 49-62.

Budygin EA, Oleson EB, Mathews TA, Lack AK, Diaz MR, McCool BA, Jones SR. Effects of chronic alcohol exposure on dopamine uptake in rat nucleus accumbens and caudate putamen. Psychopharmacology (Berl). 2007;193(4):495-501.

Mathews TA, John CE, Lapa GB, Budygin EA, Jones SR. No role of the dopamine transporter in acute ethanol effects on striatal dopamine dynamics. Synapse. 2006;60(4):288-294.

Brookshire BR, Lapa A, Mathews TA, Jones SR. Cocaine and ethanol effects on nucleus accumbens dopamine in 22-TNJ mutant mice [abstract]. Alcohol Clin Exp Res. 2006;30(6 Suppl):181A.

Budygin EA, Jones SR. Accumbal dopamine release, but not uptake or synthesis, is altered by low and moderate doses of acute ethanol [abstract]. Alcohol Clin Exp Res. 2006;30(6 Suppl):182A.

John CE, Jones SR. Exocytotic release of dopamine in ventral tegmental area slices from C57BL/6 and dopamine transporter knockout mice. Neurochem Int. 2006;49(8):737-745.

Nordskog BK, Alexander GM, Hammarback JA, Mathews TA, Jones SR, Fisher TL, Godwin DW. Alterations in the molecular physiology of T-type calcium channels during ethanol withdrawal [abstract]. Soc Neurosci Abstr. 2006;2006(Abstr Viewer):.

John CE, Budygin EA, Weiner JL, Jones SR. NMDA receptor deficient mice display altered synaptic function and reward related behaviors [abstract]. Neuropsychopharmacology. 2006;31(Suppl):S76.