Profile

Sara Jones, Ph.D.Wake Forest School of Medicine

Sara Jones, Ph.D.

Professor,


Contact Information

Academic: 336-716-8355 | Department: 336-716-8533

Email: srjones@wakehealth.edu

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Education & Training

  • B.S., University of Georgia, 1987
  • Ph.D., University of North Carolina-Chapel Hill, 1994

Memberships

  • Research Society On Alcoholism
  • Society for Neuroscience
  • Assn Of Women In Science
Sara Jones, Ph.D.

Sara Jones, Ph.D.

Professor, Physiology & Pharmacology
Center for Comparative Medicine Research
Institute for Regenerative Medicine

Research Interests

drugs/therapeutic agents pharm, mental disorders/psychiatry/ps, neurosciences/behavior, substance abuse

Contact Information

Academic: 336-716-8355 | Department: 336-716-8533

Email: srjones@wakehealth.edu

Related Links

Recent Publications

Calipari ES, Siciliano CA, Zimmer BA, Jones SR. Brief intermittent cocaine self-administration and abstinence sensitizes cocaine effects on the dopamine transporter and increases drug seeking. Neuropsychopharmacology. 2015;40(3):728-735.

Luderman KD, Chen R, Ferris MJ, Jones SR, Gnegy ME. Protein kinase C beta regulates the D2-like dopamine autoreceptor. Neuropharmacology. 2015;89():335-341.

Yorgason JT, Rose JH, McIntosh JM, Ferris MJ, Jones SR. Greater ethanol inhibition of presynaptic dopamine release in C57BL/6J than DBA/2J mice: role of nicotinic acetylcholine receptors. Neuroscience. 2015;284():854-864.

Calipari ES, Ferris MJ, Siciliano CA, Jones SR. Differential influence of dopamine transport rate on the potencies of cocaine, amphetamine, and methylphenidate. ACS Chem Neurosci. 2015;6(1):155-162.

Siciliano CA, Calipari ES, Ferris MJ, Jones SR. Adaptations of presynaptic dopamine terminals induced by psychostimulant self-administration. ACS Chem Neurosci. 2015;6(1):27-36.

Ferris MJ, Calipari ES, Rose JH, Siciliano CA, Sun H, Chen R, Jones SR. A single amphetamine infusion reverses deficits in dopamine nerve-terminal function caused by a history of cocaine self-administration. Neuropsychopharmacology. 2015;40(8):1826-1836.

Richardson JR, Taylor MM, Shalat SL, Guillot TS III, Caudle WM, Hossain MM, Mathews TA, Jones SR, Cory-Slechta DA, Miller GW. Developmental pesticide exposure reproduces features of attention deficit hyperactivity disorder. FASEB J. 2015;29(5):1960-1972.

Karkhanis AN, Rose JH, Huggins KN, Konstantopoulos JK, Jones SR. Chronic intermittent ethanol exposure reduces presynaptic dopamine neurotransmission in the mouse nucleus accumbens. Drug Alcohol Depend. 2015;150():24-30.

Siciliano CA, Calipari ES, Cuzon Carlson VC, Helms CM, Lovinger DM, Grant KA, Jones SR. Voluntary ethanol intake predicts kappa-opioid receptor supersensitivity and regionally distinct dopaminergic adaptations in macaques. J Neurosci. 2015;35(15):5959-5968.

Karkhanis AN, Alexander NJ, McCool BA, Weiner JL, Jones SR. Chronic social isolation during adolescence augments catecholamine response to acute ethanol in the basolateral amygdala. Synapse. 2015;69(8):385-395.

Willard SL, Uberseder B, Clark A, Daunais JB, Johnston WD, Neely D, Massey A, Williamson JD, Kraft RA, Bourland JD, Jones SR, Shively CA. Long term sertraline effects on neural structures in depressed and nondepressed adult female nonhuman primates. Neuropharmacology. 2015;():.

Melchior JR, Ferris MJ, Stuber GD, Riddle DR, Jones SR. Optogenetic versus electrical stimulation of dopamine terminals in the nucleus accumbens reveals local modulation of presynaptic release. J Neurochem. 2015;134(5):833-844.

Siciliano CA, Ferris MJ, Jones SR. Cocaine self-administration disrupts mesolimbic dopamine circuit function and attenuates dopaminergic responsiveness to cocaine. Eur J Neurosci. 2015;():.

Cervera-Juanes R, Wilhem LJ, Park B, Lee R, Locke J, Helms C, Gonzales S, Wand G, Jones SR, Grant KA, Ferguson B. MAOA expression predicts vulnerability for alcohol use. Mol Psychiatry. 2015;():.

Calipari ES, Ferris MJ, Melchior JR, Bermejo K, Salahpour A, Roberts DC, Jones SR. Methylphenidate and cocaine self-administration produce distinct dopamine terminal alterations. Addict Biol. 2014;19(2):145-155.

Yorgason JT, Ferris MJ, Steffensen SC, Jones SR. Frequency-dependent effects of ethanol on dopamine release in the nucleus accumbens. Alcohol Clin Exp Res. 2014;38(2):438-447.

Calipari ES, Ferris MJ, Jones SR. Extended access of cocaine self-administration results in tolerance to the dopamine-elevating and locomotor-stimulating effects of cocaine. J Neurochem. 2014;128(2):224-232.

Calipari ES, Ferris MJ, Siciliano CA, Zimmer BA, Jones SR. Intermittent cocaine self-administration produces sensitization of stimulant effects at the dopamine transporter. J Pharmacol Exp Ther. 2014;349(2):192-198.

Karkhanis A, Skelly MJ, Rau A, Yorgason J, Chappell A, Carter E, Jones S, McCool B, Weiner J. Early life stress increases behavioral and neurobiological risk factors of alcohol addiction in male Long Evans rats [abstract]. Alcohol. 2014;48(2):161.

Siciliano CA, Calipari ES, Ferris MJ, Jones SR. Biphasic mechanisms of amphetamine action at the dopamine terminal. J Neurosci. 2014;34(16):5575-5582.

Daigle TL, Ferris MJ, Gainetdinov RR, Sotnikova TD, Urs NM, Jones SR, Caron MG. Selective deletion of GRK2 alters psychostimulant-induced behaviors and dopamine neurotransmission. Neuropsychopharmacology. 2014;39(10):2450-2462.

Diaz MR, Jotty K, Locke JL, Jones SR, Valenzuela CF. Moderate alcohol exposure during the rat equivalent to the third trimester of human pregnancy alters regulation of GABAA receptor-mediated synaptic transmission by dopamine in the basolateral amygdala. Front Pediatr. 2014;2():46.

Calipari ES, Sun H, Eldeeb K, Luessen DJ, Feng X, Howlett AC, Jones SR, Chen R. Amphetamine self-administration attenuates dopamine D2 autoreceptor function. Neuropsychopharmacology. 2014;39(8):1833-1842.

Calipari ES, Jones SR. Sensitized nucleus accumbens dopamine terminal responses to methylphenidate and dopamine transporter releasers after intermittent-access self-administration. Neuropharmacology. 2014;82():1-10.

Ferris MJ, Espana RA, Locke JL, Konstantopoulos JK, Rose JH, Chen R, Jones SR. Dopamine transporters govern diurnal variation in extracellular dopamine tone. Proc Natl Acad Sci U S A. 2014;111(26):E2751-2759.

Siciliano CA, Calipari ES, Jones SR. Amphetamine potency varies with dopamine uptake rate across striatal subregions. J Neurochem. 2014;131(3):348-355.

Karkhanis AN, McCool BA, Weiner JL, Jones SR. Social isolation stress augments dopamine and norepinephrine responses to ethanol in the nucleus accumbens and the basolateral amygdala [abstract]. Alcohol Clin Exp Res. 2014;38(Suppl 1):81A.

Melchior JR, Jones SR. Optogenetic insights into ethanol effects on presynaptic dopamine terminal dynamics [abstract]. Alcohol Clin Exp Res. 2014;38(Suppl 1):82A.

Ferris MJ, Milenkovic M, Liu S, Mielnik CA, Beerepoot P, John CE, Espana RA, Sotnikova TD, Gainetdinov RR, Borgland SL, Jones SR, Ramsey AJ. Sustained N-methyl-D-aspartate receptor hypofunction remodels the dopamine system and impairs phasic signaling. Eur J Neurosci. 2014;40(1):2255-2263.

Karkhanis AN, Locke JL, McCool BA, Weiner JL, Jones SR. Social isolation rearing increases nucleus accumbens dopamine and norepinephrine responses to acute ethanol in adulthood. Alcohol Clin Exp Res. 2014;38(11):2770-2779.

Calipari E, Jones S. Cocaine self-administration-induced sensitization of the dopamine system [abstract]. FASEB J. 2014;28(1 Suppl):LB621.

Ferris M, Jones S. Individual differences in the modulation of dopamine signals in the ventral striatum by nicotinic acetylcholine receptors [abstract]. Neuropsychopharmacology. 2014;39(Suppl 1):S611.

Jones S. Cocaine self-administration induces tolerance to cocaine and reduces dopamine signaling [abstract]. Neuropsychopharmacology. 2014;39(Suppl 1):S14.

Siciliano C, Calipari E, Porrino L, Jones S. More than a replacement therapy: amphetamine treatment reverses the behavioral and neurochemical consequences of cocaine self-administration [abstract]. Neuropsychopharmacology. 2014;39(Suppl 1):S601.

Siciliano C, Calipari E, Ferris M, Chen R, Jones S. Biphasic mechanisms of amphetamine action at the dopamine terminal [abstract]. FASEB J. 2014;28(1 Suppl):661.4.

Espana RA, Jones SR. Presynaptic dopamine modulation by stimulant self-administration. Front Biosci (Schol Ed). 2013;5():261-276.

Yorgason JT, Espana RA, Konstantopoulos JK, Weiner JL, Jones SR. Enduring increases in anxiety-like behavior and rapid nucleus accumbens dopamine signaling in socially isolated rats. Eur J Neurosci. 2013;37(6):1022-1031.

Ferris MJ, Calipari ES, Yorgason JT, Jones SR. Examining the complex regulation and drug-induced plasticity of dopamine release and uptake using voltammetry in brain slices. ACS Chem Neurosci. 2013;4(5):693-703.

Karkhanis AN, Konstantopoulos J, Locke J, Weiner JL, Jones SR. Social isolation rearing increases dopamine and norepinephrine responses to ethanol and K-opioid receptor activity in nucleus accumbens [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):240A.

Rose JH, Calipari ES, Mathews TA, Jones SR. Divergent dopamine systems may underlie different neurochemical and behavioral responses to ethanol in C57Bl/6J and DBA/2J mice [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):240A.

Weiner JL, Chappell AM, Carter E, Yorgason J, Jones SR, McCool BA. Adolescent social isolation increases behavioral and neurobiological risk factors of alcoholism in male Long Evans rats [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):299A.

Yorgason JT, Schilaty ND, Hedges DM, Jang E, Jones SR, Steffensen SC. Ethanol inhibits dopamine release at terminals in the nucleus accumbens via GABA(B) receptors [abstract]. Alcohol Clin Exp Res. 2013;37(Suppl 2):240A.

Ferris MJ, Calipari ES, Melchior JR, Roberts DC, Espana RA, Jones SR. Paradoxical tolerance to cocaine after initial supersensitivity in drug-use-prone animals. Eur J Neurosci. 2013;38(4):2628-2636.

Calipari ES, Ferris MJ, Zimmer BA, Roberts DC, Jones SR. Temporal pattern of cocaine intake determines tolerance vs sensitization of cocaine effects at the dopamine transporter. Neuropsychopharmacology. 2013;38(12):2385-2392.

Calipari ES, Ferris MJ, Salahpour A, Caron MG, Jones SR. Methylphenidate amplifies the potency and reinforcing effects of amphetamines by increasing dopamine transporter expression. Nat Commun. 2013;4():2720.

Rose JH, Calipari ES, Mathews TA, Jones SR. Greater ethanol-induced locomotor activation in DBA/2J versus C57BL/6J mice is not predicted by presynaptic striatal dopamine dynamics. PLoS One. 2013;8(12):e83852.

Calipari ES, Beveridge TJ, Jones SR, Porrino LJ. Withdrawal from extended-access cocaine self-administration results in dysregulated functional activity and altered locomotor activity in rats. Eur J Neurosci. 2013;38(12):3749-3757.

Ferris MJ, Calipari ES, Mateo Y, Melchior JR, Roberts DCS, Jones SR. Cocaine self-administration produces pharmacodynamic tolerance: differential effects on the potency of dopamine transporter blockers, releasers, and methylphenidate. Neuropsychopharmacology. 2012;37(7):1708-1716.

Oleson EB, Ferris MJ, Espana RA, Harp J, Jones SR. Effects of the histamine H1 receptor antagonist and benztropine analog diphenylpyraline on dopamine uptake, locomotion and reward. Eur J Pharmacol. 2012;683(1-3):161-165.

Huggins KN, Mathews TA, Locke JL, Szeliga KT, Friedman DP, Bennett AJ, Jones SR. Effects of early life stress on drinking and serotonin system activity in rhesus macaques: 5-hydroxyindoleacetic acid in cerebrospinal fluid predicts brain tissue levels. Alcohol. 2012;46(4):371-376.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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