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Matthew J. Jorgensen, Ph.D.Wake Forest School of Medicine

Matthew J. Jorgensen, Ph.D.

Associate Professor,
Ctr for Vaccines at Extremes

Contact Information

Academic: 336-716-6935 | Department: 336-716-6935

Email: mjorgens@wakehealth.edu

Education & Training

  • B.S., University of Massachusetts-Amherst, 1989
  • M.A., University of California-Riverside, 1991
  • Ph.D., University of California-Riverside, 1994
  • Fellowship, Behavioral Science, University of California-Los A, 2000
Matthew J. Jorgensen, Ph.D.

Matthew J. Jorgensen, Ph.D.

Associate Professor, Pathology-Comparative Medicine
Ctr for Vaccines at Extremes

Research Interests

Cercopithecus aethiops; Diet; Animals; Pregnancy; Impulsive Behavior
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Contact Information

Academic: 336-716-6935 | Department: 336-716-6935

Email: mjorgens@wakehealth.edu

Recent Publications

An R848 adjuvanted influenza vaccine promotes early activation of B cells in the draining lymph node of nonhuman primate neonates. Holbrook BC, Aycock ST, Machiele E, Clemens E, Gries D, Jorgensen MJ, Hadimani MB, King SB, Alexander-Miller MA.. Immunology. 2018;153(3):357-367.

The Apathy in Dementia Methylphenidate Trial 2 (ADMET 2): study protocol for a randomized controlled trial. Scherer RW, Drye L, Mintzer J, Lanctot K, Rosenberg P, Herrmann N, Padala P, Brawman-Mintzer O, Burke W, Craft S, Lerner AJ, Levey A, Porsteinsson A, van Dyck CH, Baker LD, Williamson JD, Bell RA, Espeland M, Miller ME, Mott RT, Rapp S, Hayden K,.. Trials. 2018;19(1):46.

Neurodegenerative disease biomarkers A beta1-40, A beta1-42, tau, and p-tau181 in the vervet monkey cerebrospinal fluid: relation to normal aging, genetic influences, and cerebral amyloid angiopathy. Chen JA, Fears SC, Jasinska AJ, Huang A, Al-Sharif NB, Scheibel KE, Dyer TD, Fagan AM, Blangero J, Woods R, Jorgensen MJ, Kaplan JR, Freimer NB, Coppola G.. Brain Behav. 2018;8(2):e00903.

Pair housing of vervets/African green monkeys for biomedical research. Jorgensen MJ, Lambert KR, Breaux SD, Baker KC, Snively BM, Weed JL.. Am J Primatol. 2017;79(1):1-10.

In vivo evaluation of [18F]FECIMBI-36, an agonist 5-HT2A/2C receptor PET radioligand in nonhuman primate. Prabhakaran J, Solingapuram Sai KK, Zanderigo F, Rubin-Falcone H, Jorgensen MJ, Kaplan JR, Tooke KI, Mintz A, Mann JJ, Kumar JS.. Bioorg Med Chem Lett. 2017;27(1):21-23.

Human striatal dopaminergic and regional serotonergic synaptic degeneration with Lewy body disease and inheritance of APOE epsilon4. Postupna N, Latimer CS, Larson EB, Sherfield E, Paladin J, Shively CA, Jorgensen MJ, Andrews RN, Kaplan JR, Crane PK, Montine KS, Craft S, Keene CD, Montine TJ.. Am J Pathol. 2017;187(4):884-895.

Behavioral management of Chlorocebus spp. Jorgensen MJ. In: Schapiro SJ, ed. Handbook of primate behavioral management. Boca Raton (FL): CRC Press, Taylor & Francis Group;2017: 339-365.

Automated radiosynthesis and in vivo PET evaluation of GSK3 ligand [C-11] A1070722 in NHP brain [abstract]. Sai KKS, Prabhakaran J, Zanderigo F, Jorgensen M, Kaplan J, Mann J, Mintz A, Kumar D.. J Nucl Med. 2017;58(Suppl 1):867.

The use of African green monkeys in modeling HIV/AIDS and SIV infection [abstract]. Caudell DL, Jorgensen MJ, Kavanagh K, Kaplan JR.. J Med Primatol. 2017;46(4):193.

Automated synthesis of 1-[11C]acetoacetate on a TRASIS AIO module. Solingapuram Sai KK, Donald Gage H, Almaguel F, Neth B, Hughes TM, Tremblay S, Castellano CA, Cunnane SC, Jorgensen MJ, Craft S, Mintz A.. Appl Radiat Isot. 2017;129():57-61.

Radiosynthesis and in vivo evaluation of [11C]A1070722, a high affinity GSK-3 PET tracer in primate brain. Prabhakaran J, Zanderigo F, Sai KKS, Rubin-Falcone H, Jorgensen MJ, Kaplan JR, Mintz A, Mann JJ, Kumar JSD.. ACS Chem Neurosci. 2017;8(8):1697-1703.

Adjuvanting an inactivated influenza vaccine with conjugated R848 improves the level of antibody present at 6 months in a nonhuman primate neonate model. Holbrook BC, D'Agostino RB Jr, Tyler Aycock S, Jorgensen MJ, Hadimani MB, Bruce King S, Alexander-Miller MA.. Vaccine. 2017;35(45):6137-6142.

Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate. Jasinska AJ, Zelaya I, Service SK, Peterson CB, Cantor RM, Choi OW, DeYoung J, Eskin E, Fairbanks LA, Fears S, Furterer AE, Huang YS, Ramensky V, Schmitt CA, Svardal H, Jorgensen MJ, Kaplan JR, Villar D, Aken BL, Flicek P, Nag R, Wong ES,.. Nat Genet. 2017;49(12):1714-1721.

Blood-based bioenergetic profiling reflects differences in brain bioenergetics and metabolism. Tyrrell DJ, Bharadwaj MS, Jorgensen MJ, Register TC, Shively C, Andrews RN, Neth B, Dirk Keene C, Mintz A, Craft S, Molina AJA.. Oxid Med Cell Longev. 2017;2017():7317251.

Obesity and obesogenic growth are both highly heritable and modified by diet in a nonhuman primate model, the African green monkey (Chlorocebus aethiops sabaeus). Schmitt CA, Service SK, Jasinska AJ, Dyer TD, Jorgensen MJ, Cantor RM, Weinstock GM, Blangero J, Kaplan JR, Freimer NB.. Int J Obes (Lond). 2017;():.

Vitamin D heritability and effect of pregnancy status in vervet monkeys (Chlorocebus aethiops sabaeus) under conditions of modest and high dietary supplementation. Chittoor G, Pajewski NM, Voruganti VS, Comuzzie AG, Clarkson TB [deceased], Nudy M, Schnatz PF, Kaplan JR, Jorgensen MJ.. Am J Phys Anthropol. 2016;159(4):639-645.

Alterations in levels and ratios of n-3 and n-6 polyunsaturated fatty acids in the temporal cortex and liver of vervet monkeys from birth to early adulthood. Miller LR, Jorgensen MJ, Kaplan JR, Seeds MC, Rahbar E, Morgan TM, Welborn A, Chilton SM, Gillis J, Hester A, Rukstalis M, Sergeant S, Chilton FH.. Physiol Behav. 2016;156():71-78.

A novel R848-conjugated inactivated influenza virus vaccine is efficacious and safe in a neonate nonhuman primate model. Holbrook BC, Kim JR, Blevins LK, Jorgensen MJ, Kock ND, D'Agostino RB Jr, Aycock ST, Hadimani MB, King SB, Parks GD, Alexander-Miller MA.. J Immunol. 2016;197(2):555-564.

The aging vervet as a model of Alzheimer's disease [abstract]. Latimer C, Kaplan J, Shively C, Cline J, Andrews R, Jorgensen M, Craft S, Montine T, Keene C.. J Neuropathol Exp Neurol. 2016;75(6):604.

Blood cell respirometry is associated with skeletal and cardiac muscle bioenergetics: implications for a minimally invasive biomarker of mitochondrial health. Tyrrell DJ, Bharadwaj MS, Jorgensen MJ, Register TC, Molina AJ.. Redox Biol. 2016;10():65-77.

A novel R848-conjugated inactivated influenza virus vaccine is safe and efficacious in a neonate nonhuman primate model [abstract]. Holbrook B, Kim J, Blevins L, Jorgensen M, Kock N, D'Agostino R Jr, Aycock ST, Hadimani M, King SB, Parks G, Alexander-Miller M.. Eur J Immunol. 2016;46(Suppl 1):31.

Maternal effects influence the heritability of adult obesity traits but not obesogenic growth trajectories in vervet monkeys (Chlorocebus spp.) [abstract]. Schmitt CA, Service SK, Cantor RM, Jasinska AJ, Jorgensen MJ, Kaplan JR, Freimer NB.. Am J Phys Anthropol. 2015;156(Suppl 60):279.

Inclusion of flagellin during vaccination against influenza enhances recall responses in nonhuman primate neonates. Kim JR, Holbrook BC, Hayward SL, Blevins LK, Jorgensen MJ, Kock ND, De Paris K, D'Agostino R Jr, Aycock ST, Mizel SB, Parks GD, Alexander-Miller MA.. J Virol. 2015;89(14):7291-7303.

Sequencing strategies and characterization of 721 vervet monkey genomes for future genetic analyses of medically relevant traits. Huang YS, Ramensky V, Service SK, Jasinska AJ, Jung Y, Choi OW, Cantor RM, Juretic N, Wasserscheid J, Kaplan JR, Jorgensen MJ, Dyer TD, Dewar K, Blangero J, Wilson RK, Warren W, Weinstock GM, Freimer NB.. BMC Biol. 2015;13():41.

Hematology and clinical chemistry measures during and after pregnancy and age- and sex-specific reference intervals in African green monkeys (Chlorocebus aethiops sabaeus). Chichester L, Gee MK, Jorgensen MJ, Kaplan JR.. J Am Assoc Lab Anim Sci. 2015;54(4):359-367.

The genome of the vervet (Chlorocebus aethiops sabaeus). Warren WC, Jasinska AJ, Garcia-Perez R, Svardal H, Tomlinson C, Rocchi M, Archidiacono N, Capozzi O, Minx P, Montague MJ, Kyung K, Hillier LW, Kremitzki M, Graves T, Chiang C, Hughes J, Tran N, Huang Y, Ramensky V, Choi OW, Jung YJ, Schmitt CA,.. Genome Res. 2015;25(12):1921-1933.

Genetic regulation of hippocampal size trait in vervet monkeys [abstract]. Jasinska AJ, Service S, Fears S, Zelaya I, Huang Y, Navarro L, Jorgensen M, Weinstock G, Warren W, Woods R, Coppola G, Freimer N.. Am J Primatol. 2015;77(Suppl 1):55.

Novelty seeking in vervets: genetic and environmental influences [abstract]. Fairbanks LA, Jorgensen MJ, Bailey JN.. Am J Phys Anthropol. 2014;153(Suppl 58):115-116.

Heritability of obesogenic growth trajectories during development in captive vervet monkeys (Chlorocebus aethiops sabaeus) [abstract]. Schmitt CA, Service S, Cantor RM, Jasinska AJ, Jorgensen MJ, Kaplan JR, Freimer NB.. Am J Phys Anthropol. 2014;153(Suppl 58):231-232.

The hair-diet C-13 and N-15 fractionation in Chlorocebus aethiops sabaeus based on a control diet study. Macharia AN, Cerling TE Jorgensen MJ, Kaplan JR.. Ann Zool Fennici. 2014;51(1-2):66-72.

High genetic heritability of obesogenic growth in captive vervet monkey (chlorocebus SPP) [abstract]. Schmitt CA, Service S, Cantor RM, Jasinska AJ, Jorgensen MJ, Kaplan JR, Freimer NB.. Am J Primatol. 2014;76(Suppl 1):74.

Genetics and development of obesity in captive vervet monkeys (Chlorocebus aethiops sabaeus) [abstract]. Schmitt CA, Service S, Cantor RM, Jasinska AJ, Jorgensen MJ, Kaplan JR, Freimer NB.. Am J Phys Anthropol. 2013;150(Suppl 56):243.

Development of amyloid burden in African Green monkeys. Kalinin S, Willard SL, Shively CA, Kaplan JR, Register TC, Jorgensen MJ, Polak PE, Rubinstein I, Feinstein DL.. Neurobiol Aging. 2013;34(10):2361-2369.

Significant genotype by diet (G X D) interaction effects on cardiometabolic responses to a pedigree-wide, dietary challenge in vervet monkeys (Chlorocebus aethiops sabaeus). Voruganti VS, Jorgensen MJ, Kaplan JR, Kavanagh K, Rudel LL, Temel R, Fairbanks LA, Comuzzie AG.. Am J Primatol. 2013;75(5):491-499.

Age-related degenerative functional, radiographic, and histological changes of the shoulder in nonhuman primates. Plate JF, Bates CM, Mannava S, Smith TL, Jorgensen MJ, Register TC, Stehle JR, High KP, Shively CA, Kaplan JR, Saul KR, Tuohy CJ.. J Shoulder Elbow Surg. 2013;22(8):1019-1029.

Hydrogen and oxygen isotope ratios in body water and hair: modeling isotope dynamics in nonhuman primates. O'Grady SP, Valenzuela LO, Remien CH, Enright LE, Jorgensen MJ, Kaplan JR, Wagner JD, Cerling TE, Ehleringer JR.. Am J Primatol. 2012;74(7):651-660.

A non-human primate system for large-scale genetic studies of complex traits. Jasinska AJ, Lin MK, Service S, Choi O-W, DeYoung J, Grujic O, Kong S-Y, Jung Y, Jorgensen MJ, Fairbanks LA, Turner T, Cantor RM, Wasserscheid J, Dewar K, Warren W, Wilson RK, Weinstock G, Jentsch JD, Freimer NB.. Hum Mol Genet. 2012;21(15):3307-3316.

Phenotypic and genetic correlations between plasma oxytocin and affiliative approach in vervet monkeys [abstract]. Fairbanks LA, Jorgensen MJ, Bales KL.. Am J Primatol. 2012;74(Suppl 1):54.

The vervet research colony as a biomedical resource [abstract]. Jorgensen MJ, Rudel LL, Kavanagh K, Jasinska AJ, Freimer NB, Jentsch JD, Fairbanks LA, Fallon MT, Kaplan JR.. Am J Primatol. 2012;74(Suppl 1):68.

Aging does not reduce heat shock protein 70 in the absence of chronic insulin resistance. Kavanagh K, Wylie AT, Chavanne TJ, Jorgensen MJ, Voruganti VS, Comuzzie AG, Kaplan JR, McCall CE, Kritchevsky SB.. J Gerontol A Biol Sci Med Sci. 2012;67(10):1014-1021.

25(OH)D3 and cardiovascular risk factors in female nonhuman primates. Jorgensen MJ, Rudel LL, Nudy M, Kaplan JR, Clarkson TB, Pajewski NM, Schnatz PF.. J Womens Health. 2012;21(9):959-965.

Developmental patterns of hair cortisol in male and female nonhuman primates: lower hair cortisol levels in vervet males emerge at puberty. Laudenslager ML, Jorgensen MJ, Fairbanks LA.. Psychoneuroendocrinology. 2012;37(10):1736-1739.

Maternal and offspring dopamine D4 receptor genotypes interact to influence juvenile impulsivity in vervet monkeys. Fairbanks LA, Way BM, Breidenthal SE, Bailey JN, Jorgensen MJ.. Psychol Sci. 2012;23(10):1099-1104.

A web-based brain atlas of the vervet monkey, Chlorocebus aethiops. Woods RP, Fears SC, Jorgensen MJ, Fairbanks LA, Toga AW, Freimer NB.. Neuroimage. 2011;54(3):1872-1880.

Fetal and maternal factors associated with infant mortality in vervet monkeys. Kavanagh K, Dozier BL, Chavanne TJ, Fairbanks LA, Jorgensen MJ, Kaplan JR.. J Med Primatol. 2011;40(1):27-36.

Canaries in the coal mine: a cross-species analysis of the plurality of obesity epidemics. Klimentidis YC, Beasley TM, Lin H-Y, Murati G, Glass GE, Guyton M, Newton W, Jorgensen M, Heymsfield SB, Kemnitz J, et al.. Proc Biol Sci. 2011;278(1712):1626-1632.

A novelty seeking phenotype is related to chronic hypothalamic-pituitary-adrenal activity reflected by hair cortisol. Laudenslager ML, Jorgensen MJ, Grzywa R, Fairbanks LA.. Physiol Behav. 2011;104(2):291-295.

Heritability and genetic correlation of hair cortisol in vervet monkeys in low and higher stress environments. Fairbanks LA, Jorgensen MJ, Bailey JN, Breidenthal SE, Grzywa R, Laudenslager ML.. Psychoneuroendocrinology. 2011;36(8):1201-1208.

Environmental stress alters genetic regulation of novelty seeking in vervets [abstract]. Fairbanks LA, Bailey JN, Breidenthal SE, Laudenslager ML, Kaplan JR, Jorgensen MJ.. Am J Primatol. 2011;73(Suppl 1):84.

CCR5 expression on CD4+T cells and not CD4 downregulation impacts the efficacy of SIVagm mucosal transmission in African green monkeys (AGMS) [abstract]. Kuhrt D, Nusbaum R, Garlena R, Nguyen T, Jorgensen MJ, Silvestri G, Kaplan J, Apetrei C, Pandrea I.. J Med Primatol. 2011;40(4):256.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Pathology-Comparative Medicine

Matthew J. Jorgensen, Ph.D.

Matthew J. Jorgensen, Ph.D.

Associate Professor, Pathology-Comparative Medicine
Ctr for Vaccines at Extremes

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