Jay R. Kaplan, Ph.D.Wake Forest School of Medicine

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Education & Training

  • B.A., Swarthmore College, 1968
  • M.A., Northwestern University, 1970
  • Ph.D., Northwestern University, 1976


  • Acad for Beh Medicine Research
  • Aha - Council On Arteriosclero
  • Am Anthropological Assn
  • Am Assn Of Physical Anthropolo
  • Am Soc Of Mammalogists
  • Am Soc Of Primatologists
  • Am Soc Of Reproductive Med
  • North Am Menopause Soc
Jay R. Kaplan, Ph.D.

Jay R. Kaplan, Ph.D.

Shared Resource Director, Translational Science Institute
Director, Center for Comparative Medicine Research
Vice Chair, Pathology
Professor, Pathology-Comparative Medicine
Translational Science Institute
Center for Comparative Medicine Research
Hypertension and Vascular Research Center
Sticht Center on Aging

Research Interests

cardiac function, cross(mult/tnslat/inter)discip, genetics/genome, health services, research/outc, immunology/allergy/inflammatio, infectious diseases, model development, molecular biology/molecular me, neurosciences/behavior, nutrition, primary care, radiology imaging/nuclear medi, vaccines, women's health issues

Contact Information

Academic: 336-716-1522 | Department: 336-716-1522


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Recent Publications

Melendez GC, Register TC, Appt SE, Clarkson TB, Franke AA, Kaplan JR. Beneficial effects of soy supplementation on postmenopausal atherosclerosis are dependent on pretreatment stage of plaque progression. Menopause. 2015;22(3):289-296.

Johnson Z, Brent L, Alvarenga JC, Comuzzie AG, Shelledy W, Ramirez S, Cox L, Mahaney MC, Huang YY, Mann JJ, Kaplan JR, Rogers J. Genetic influences on response to novel objects and dimensions of personality in Papio baboons. Behav Genet. 2015;45(2):215-227.

Montague MJ, Hillier L, Jasinsk AJ, Turner T, Kaplan J, Jorgensen MJ, Freimer N, Weinstock G, Wilson RK, Warren WC. Structural variant discovery among related vervet monkeys [abstract]. Am J Phys Anthropol. 2015;156(Suppl 60):228.

Schmitt CA, Service SK, Cantor RM, Jasinska AJ, Jorgensen MJ, Kaplan JR, Freimer NB. Maternal effects influence the heritability of adult obesity traits but not obesogenic growth trajectories in vervet monkeys (Chlorocebus spp.) [abstract]. Am J Phys Anthropol. 2015;156(Suppl 60):279.

Huang YS, Ramensky V, Service SK, Jasinska AJ, Jung Y, Choi OW, Cantor RM, Juretic N, Wasserscheid J, Kaplan JR, Jorgensen MJ, Dyer TD, Dewar K, Blangero J, Wilson RK, Warren W, Weinstock GM, Freimer NB. Sequencing strategies and characterization of 721 vervet monkey genomes for future genetic analyses of medically relevant traits. BMC Biol. 2015;13():41.

Chichester L, Gee MK, Jorgensen MJ, Kaplan JR. Hematology and clinical chemistry measures during and after pregnancy and age- and sex-specific reference intervals in African green monkeys (Chlorocebus aethiops sabaeus). J Am Assoc Lab Anim Sci. 2015;54(4):359-367.

Prabhakaran J, DeLorenzo C, Pratap M, Jorgenson M, Kaplan JR, Knudsen G, Parsey R, Mann J, Kumar JSD. Quantification 11C CIMBI-5, a 5-HT2AR agonist PET ligand in vervet monkey [abstract]. J Nucl Med. 2015;56(3 Suppl 3):1558.

Warren WC, Jasinska AJ, Garcia-Perez R, Svardal H, Tomlinson C, Rocchi M, Archidiacono N, Capozzi O, Minx P, Montague MJ, Kyung K, Hillier LW, Kremitzki M, Graves T, Chiang C, Hughes J, Tran N, Huang Y, Ramensky V, Choi OW, Jung YJ, Schmitt CA,. The genome of the vervet (Chlorocebus aethiops sabaeus). Genome Res. 2015;25(12):1921-1933.

Chittoor G, Pajewski NM, Voruganti VS, Comuzzie AG, Clarkson TB [deceased], Nudy M, Schnatz PF, Kaplan JR, Jorgensen MJ. Vitamin D heritability and effect of pregnancy status in vervet monkeys (Chlorocebus aethiops sabaeus) under conditions of modest and high dietary supplementation. Am J Phys Anthropol. 2015;():.

Miller LR, Jorgensen MJ, Kaplan JR, Seeds MC, Rahbar E, Morgan TM, Welborn A, Chilton SM, Gillis J, Hester A, Rukstalis M, Sergeant S, Chilton FH. Alterations in levels and ratios of n-3 and n-6 polyunsaturated fatty acids in the temporal cortex and liver of vervet monkeys from birth to early adulthood. Physiol Behav. 2015;():.

Atkins HM, Willson CJ, Silverstein M, Jorgensen M, Floyd E, Kaplan JR, Appt SE. Characterization of ovarian aging and reproductive senescence in vervet monkeys (Chlorocebus aethiops sabaeus). Comp Med. 2014;64(1):55-62.

Schmitt CA, Service S, Cantor RM, Jasinska AJ, Jorgensen MJ, Kaplan JR, Freimer NB. Heritability of obesogenic growth trajectories during development in captive vervet monkeys (Chlorocebus aethiops sabaeus) [abstract]. Am J Phys Anthropol. 2014;153(Suppl 58):231-232.

Macharia AN, Cerling TE Jorgensen MJ, Kaplan JR. The hair-diet C-13 and N-15 fractionation in Chlorocebus aethiops sabaeus based on a control diet study. Ann Zool Fennici. 2014;51(1-2):66-72.

Silverstein MG, Kaplan JR, Appt SE, Register TC, Shively CA. Effect of soy isoflavones on thyroid hormones in intact and ovariectomized cynomolgus monkeys (Macaca fascicularis). Menopause. 2014;21(10):1136-1142.

Schmitt CA, Service S, Cantor RM, Jasinska AJ, Jorgensen MJ, Kaplan JR, Freimer NB. High genetic heritability of obesogenic growth in captive vervet monkey (chlorocebus SPP) [abstract]. Am J Primatol. 2014;76(Suppl 1):74.

Schmitt CA, Service S, Cantor RM, Jasinska AJ, Jorgensen MJ, Kaplan JR, Freimer NB. Genetics and development of obesity in captive vervet monkeys (Chlorocebus aethiops sabaeus) [abstract]. Am J Phys Anthropol. 2013;150(Suppl 56):243.

Jolly CJ, Phillips-Conroy JE, Kaplan JR, Mann JJ. Monoamine neurotransmitter metabolites in the cerebrospinal fluid of a group of hybrid baboons (Papio hamadryas x P-anubis). Int J Primatol. 2013;34(4):836-858.

Kalinin S, Willard SL, Shively CA, Kaplan JR, Register TC, Jorgensen MJ, Polak PE, Rubinstein I, Feinstein DL. Development of amyloid burden in African Green monkeys. Neurobiol Aging. 2013;34(10):2361-2369.

Voruganti VS, Jorgensen MJ, Kaplan JR, Kavanagh K, Rudel LL, Temel R, Fairbanks LA, Comuzzie AG. Significant genotype by diet (G X D) interaction effects on cardiometabolic responses to a pedigree-wide, dietary challenge in vervet monkeys (Chlorocebus aethiops sabaeus). Am J Primatol. 2013;75(5):491-499.

Plate JF, Bates CM, Mannava S, Smith TL, Jorgensen MJ, Register TC, Stehle JR, High KP, Shively CA, Kaplan JR, Saul KR, Tuohy CJ. Age-related degenerative functional, radiographic, and histological changes of the shoulder in nonhuman primates. J Shoulder Elbow Surg. 2013;22(8):1019-1029.

Jasinska AJ, Schmitt CA, Service SK, Cantor RM, Dewar K, Jentsch JD, Kaplan JR, Turner TR, Warren WC, Weinstock GM, Woods RP, Freimer NB. Systems biology of the vervet monkey. ILAR J. 2013;54(2):122-143.

Appt SE, Kaplan JR, Clarkson TB. Premenopausal antimullerian hormone is a risk marker for postmenopausal coronary artery atherosclerosis progression in cynomolgus monkeys [abstract]. Menopause. 2013;20(12):1324.

Ethun KF, Wood CE, Parker CR, Kaplan JR, Chen H, Appt SE. Effect of ovarian aging on androgen biosynthesis in a cynomolgus macaque model. Climacteric. 2012;15(1):82-92.

Shelton KA, Clarkson TB, Kaplan JR. Nonhuman primate models of atherosclerosis In: Abee CR, Mansfield K, Tardif S, Morris T, eds. Nonhuman primates in biomedical research, vol 2: diseases. 2nd ed. Boston: Elsevier Academic Press;2012: 385-411.

O'Grady SP, Valenzuela LO, Remien CH, Enright LE, Jorgensen MJ, Kaplan JR, Wagner JD, Cerling TE, Ehleringer JR. Hydrogen and oxygen isotope ratios in body water and hair: modeling isotope dynamics in nonhuman primates. Am J Primatol. 2012;74(7):651-660.

Wood CE, Stavisky RC, Nowak J, Kaplan JR. Stimulatory adrenocortical effects of a selective estrogen receptor modulator in ovariectomized female macaques. Toxicol Pathol. 2012;40(1):55-61.

Nader MA, Nader SH, Czoty PW, Riddick NV, Gage HD, Gould RW, Blaylock BL, Kaplan JR, Garg PK, Davies HML, Morton D, Garg S, Reboussin BA. Social dominance in female monkeys: dopamine receptor function and cocaine reinforcement. Biol Psychiatry. 2012;72(5):414-421.

Schnatz PF, Nudy M, O'Sullivan DM, Jiang X, Cline JM, Kaplan JR, Clarkson TB, Appt SE. Coronary artery vitamin D receptor expression and plasma concentrations of 25-hydroxyvitamin D: their association with atherosclerosis. Menopause. 2012;19(9):967-973.

Jorgensen MJ, Rudel LL, Kavanagh K, Jasinska AJ, Freimer NB, Jentsch JD, Fairbanks LA, Fallon MT, Kaplan JR. The vervet research colony as a biomedical resource [abstract]. Am J Primatol. 2012;74(Suppl 1):68.

Kavanagh K, Wylie AT, Chavanne TJ, Jorgensen MJ, Voruganti VS, Comuzzie AG, Kaplan JR, McCall CE, Kritchevsky SB. Aging does not reduce heat shock protein 70 in the absence of chronic insulin resistance. J Gerontol A Biol Sci Med Sci. 2012;67(10):1014-1021.

Jorgensen MJ, Rudel LL, Nudy M, Kaplan JR, Clarkson TB, Pajewski NM, Schnatz PF. 25(OH)D3 and cardiovascular risk factors in female nonhuman primates. J Womens Health. 2012;21(9):959-965.

Schnatz PF, Vila-Wright S, Jiang X, Register TC, Kaplan JR, Clarkson TB, Appt SE. The association between plasma 25-hydroxyvitamin D3 concentrations, C-reactive protein levels, and coronary artery atherosclerosis in postmenopausal monkeys. Menopause. 2012;19(10):1074-1080.

Schnatz PF, Nudy M, O'Sullivan DM, Jiang X, Cline JM, Kaplan JR, Clarkson TB, Appt SE. The quantification of vitamin D receptors in coronary arteries and their association with atherosclerosis. Maturitas. 2012;73(2):143-147.

Appt SE, Chen H, Clarkson TB, Kaplan JR. Premenopausal antimullerian hormone concentration is associated with subsequent atherosclerosis. Menopause. 2012;19(12):1353-1359.

Kavanagh K, Dozier BL, Chavanne TJ, Fairbanks LA, Jorgensen MJ, Kaplan JR. Fetal and maternal factors associated with infant mortality in vervet monkeys. J Med Primatol. 2011;40(1):27-36.

Hamilton RT, Rettberg JR, Mao Z, To J, Zhao L, Appt SE, Register TC, Kaplan JR, Brinton RD. Hippocampal responsiveness to 17 beta-estradiol and equol after long-term ovariectomy: implication for a therapeutic window of opportunity. Brain Res. 2011;1379():11-22.

Rettberg JR, Hamilton RT, Mao Z, To J, Zhao L, Appt SE, Register TC, Kaplan JR, Brinton RD. The effect of dietary soy isoflavones before and after ovariectomy on hippocampal protein markers of mitochondrial bioenergetics and antioxidant activity in female monkeys. Brain Res. 2011;1379():23-33.

Fairbanks LA, Bailey JN, Breidenthal SE, Laudenslager ML, Kaplan JR, Jorgensen MJ. Environmental stress alters genetic regulation of novelty seeking in vervet monkeys. Genes Brain Behav. 2011;10(6):683-688.

Fairbanks LA, Bailey JN, Breidenthal SE, Laudenslager ML, Kaplan JR, Jorgensen MJ. Environmental stress alters genetic regulation of novelty seeking in vervets [abstract]. Am J Primatol. 2011;73(Suppl 1):84.

Kuhrt D, Nusbaum R, Garlena R, Nguyen T, Jorgensen MJ, Silvestri G, Kaplan J, Apetrei C, Pandrea I. CCR5 expression on CD4+T cells and not CD4 downregulation impacts the efficacy of SIVagm mucosal transmission in African green monkeys (AGMS) [abstract]. J Med Primatol. 2011;40(4):256.

Voruganti V, Jorgensen MJ, Kaplan JR, Kauanagh K [sic] [Kavanagh K], Rudel LL, Temel R, Fairbanks LA, Comuzzie AG. Significant genotype by diet (GXD) interaction effects on cardiometabolic responses to a pedigree-wide, dietary challenge in Vervet monkeys (Chlorocebus aethiops sabaeus) [abstract]. Am J Primatol. 2011;73(Suppl 1):84.

Appt SE, Kavanagh K, Chen H, Kaplan JR, Lazar J, Clarkson TB. Pulse wave velocity is positively correlated with atherosclerosis extent in midlife female nonhuman primates [abstract]. Menopause. 2011;18(12):1348.

Jorgensen MJ, Schnatz PF, Rudel LL, Nudy M, Kaplan JR, Clarkson TB. Low plasma concentrations of vitamin D3 are associated with increased cardiovascular risk factors in a female nonhuman primate model [abstract]. Menopause. 2011;18(12):1345.

Schnatz PF, Vila-Wright S, Jiang X, Register TC, Appt SE, Kaplan JR, Clarkson TB. An inverse relationship between plasma vitamin D concentrations and C-reactive protein provides a potential mechanism for cardioprotection [abstract]. Menopause. 2011;18(12):1352.

Wood CE, Kaplan JR, Fontenot MB, Williams JK, Cline JM. Endometrial profile of tamoxifen and low-dose estradiol combination therapy. Clin Cancer Res. 2010;16(3):946-956.

Jones JC, Appt SE, Werre SR, Tan JC, Kaplan JR. Validation of multi-detector computed tomography as a non-invasive method for measuring ovarian volume in macaques (Macaca fascicularis). Am J Primatol. 2010;72(6):530-538.

Christ GJ, Melman A, Williams K, Aboushwareb T, Zhao WX, Kaplan J, Anderson K-E [sic] [Andersson K-E]. Nonhuman primates as a model for translational research on atherosclerosis-related vascular disease and erectile dysfunction [abstract]. J Sex Med. 2010;7(Suppl 1):46.

Appt SE, Chen H, Goode AK, Hoyer PB, Clarkson TB, Adams MR, Wilson ME, Franke AA, Kaplan JR. The effect of diet and cardiovascular risk on ovarian aging in cynomolgus monkeys (Macaca fascicularis). Menopause. 2010;17(4):741-748.

Appt SE, Clarkson TB, Hoyer PB, Kock ND, Goode AK, May MC, Persyn JT, Ethun KF, Chen H, Kaplan JR, et al. Experimental induction of reduced ovarian reserve in a nonhuman primate model (Macaca fascicularis). Comp Med. 2010;60(5):380-388.

Kaplan JR, Chen H, Appt SE, Lees CJ, Franke AA, Berga SL, Wilson ME, Manuck SB, Clarkson TB. Impairment of ovarian function and associated health-related abnormalities are attributable to low social status in premenopausal monkeys and not mitigated by a high-isoflavone soy diet. Hum Reprod. 2010;25(12):3083-3094.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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