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Jay R. Kaplan, Ph.D.Wake Forest School of Medicine

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Education & Training

  • B.A., Swarthmore College , 1968
  • M.A., Northwestern University , 1970
  • Ph.D., Northwestern University , 1976

Memberships

  • Am Anthropological Assn
  • North Am Menopause Soc
  • Am Assn Of Physical Anthropolo
  • Acad for Beh Medicine Research
  • Am Soc Of Mammalogists
  • Aha - Council On Arteriosclero
  • Am Soc Of Primatologists
  • Am Soc Of Reproductive Med
Jay R. Kaplan, Ph.D.

Jay R. Kaplan, Ph.D.

Director, Center for Comparative Medicine Research
Shared Resource Director, Translational Science Institute
Professor, Pathology-Comparative Medicine
Translational Science Institute
Hypertension and Vascular Research Center
Sticht Center on Aging
Center for Comparative Medicine Research

Research Interests

atherosclerosis/thrombosis, cross(mult/tnslat/inter)discip, genetics/genome, health services, research/outc, immunology/allergy/inflammatio, infectious diseases, information sciences, mental disorders/psychiatry/ps, model development, neurosciences/behavior, nutrition, primary care, vaccines

Contact Information

Academic: 336-716-1522 | Department: 336-716-1522

Email: jkaplan@wakehealth.edu

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Recent Publications

Atkins HM, Willson CJ, Silverstein M, Jorgensen M, Floyd E, Kaplan JR, Appt SE. Characterization of ovarian aging and reproductive senescence in vervet monkeys (Chlorocebus aethiops sabaeus). Comp Med. 2014;64(1):55-62.

Schmitt CA, Service S, Cantor RM, Jasinska AJ, Jorgensen MJ, Kaplan JR, Freimer NB. Heritability of obesogenic growth trajectories during development in captive vervet monkeys (Chlorocebus aethiops sabaeus) [abstract]. Am J Phys Anthropol. 2014;153(Suppl 58):231-232.

Macharia AN, Cerling TE Jorgensen MJ, Kaplan JR. The hair-diet C-13 and N-15 fractionation in Chlorocebus aethiops sabaeus based on a control diet study. Ann Zool Fennici. 2014;51(1-2):66-72.

Silverstein MG, Kaplan JR, Appt SE, Register TC, Shively CA. Effect of soy isoflavones on thyroid hormones in intact and ovariectomized cynomolgus monkeys (Macaca fascicularis). Menopause. 2014;21(10):.

Melendez GC, Register TC, Appt SE, Clarkson TB, Franke AA, Kaplan JR. Beneficial effects of soy supplementation on postmenopausal atherosclerosis are dependent on pretreatment stage of plaque progression. Menopause. 2014;():.

Schmitt CA, Service S, Cantor RM, Jasinska AJ, Jorgensen MJ, Kaplan JR, Freimer NB. Genetics and development of obesity in captive vervet monkeys (Chlorocebus aethiops sabaeus) [abstract]. Am J Phys Anthropol. 2013;150(Suppl 56):243.

Jolly CJ, Phillips-Conroy JE, Kaplan JR, Mann JJ. Monoamine neurotransmitter metabolites in the cerebrospinal fluid of a group of hybrid baboons (Papio hamadryas x P-anubis). Int J Primatol. 2013;34(4):836-858.

Kalinin S, Willard SL, Shively CA, Kaplan JR, Register TC, Jorgensen MJ, Polak PE, Rubinstein I, Feinstein DL. Development of amyloid burden in African Green monkeys. Neurobiol Aging. 2013;34(10):2361-2369.

Voruganti VS, Jorgensen MJ, Kaplan JR, Kavanagh K, Rudel LL, Temel R, Fairbanks LA, Comuzzie AG. Significant genotype by diet (G X D) interaction effects on cardiometabolic responses to a pedigree-wide, dietary challenge in vervet monkeys (Chlorocebus aethiops sabaeus). Am J Primatol. 2013;75(5):491-499.

Plate JF, Bates CM, Mannava S, Smith TL, Jorgensen MJ, Register TC, Stehle JR, High KP, Shively CA, Kaplan JR, Saul KR, Tuohy CJ. Age-related degenerative functional, radiographic, and histological changes of the shoulder in nonhuman primates. J Shoulder Elbow Surg. 2013;22(8):1019-1029.

Jasinska AJ, Schmitt CA, Service SK, Cantor RM, Dewar K, Jentsch JD, Kaplan JR, Turner TR, Warren WC, Weinstock GM, Woods RP, Freimer NB. Systems biology of the vervet monkey. ILAR J. 2013;54(2):122-143.

Appt SE, Kaplan JR, Clarkson TB. Premenopausal antimullerian hormone is a risk marker for postmenopausal coronary artery atherosclerosis progression in cynomolgus monkeys [abstract]. Menopause. 2013;20(12):1324.

Ethun KF, Wood CE, Parker CR, Kaplan JR, Chen H, Appt SE. Effect of ovarian aging on androgen biosynthesis in a cynomolgus macaque model. Climacteric. 2012;15(1):82-92.

Shelton KA, Clarkson TB, Kaplan JR.Nonhuman primate models of atherosclerosis

O'Grady SP, Valenzuela LO, Remien CH, Enright LE, Jorgensen MJ, Kaplan JR, Wagner JD, Cerling TE, Ehleringer JR. Hydrogen and oxygen isotope ratios in body water and hair: modeling isotope dynamics in nonhuman primates. Am J Primatol. 2012;74(7):651-660.

Wood CE, Stavisky RC, Nowak J, Kaplan JR. Stimulatory adrenocortical effects of a selective estrogen receptor modulator in ovariectomized female macaques. Toxicol Pathol. 2012;40(1):55-61.

Nader MA, Nader SH, Czoty PW, Riddick NV, Gage HD, Gould RW, Blaylock BL, Kaplan JR, Garg PK, Davies HML, Morton D, Garg S, Reboussin BA. Social dominance in female monkeys: dopamine receptor function and cocaine reinforcement. Biol Psychiatry. 2012;72(5):414-421.

Schnatz PF, Nudy M, O'Sullivan DM, Jiang X, Cline JM, Kaplan JR, Clarkson TB, Appt SE. Coronary artery vitamin D receptor expression and plasma concentrations of 25-hydroxyvitamin D: their association with atherosclerosis. Menopause. 2012;19(9):967-973.

Jorgensen MJ, Rudel LL, Kavanagh K, Jasinska AJ, Freimer NB, Jentsch JD, Fairbanks LA, Fallon MT, Kaplan JR. The vervet research colony as a biomedical resource [abstract]. Am J Primatol. 2012;74(Suppl 1):68.

Kavanagh K, Wylie AT, Chavanne TJ, Jorgensen MJ, Voruganti VS, Comuzzie AG, Kaplan JR, McCall CE, Kritchevsky SB. Aging does not reduce heat shock protein 70 in the absence of chronic insulin resistance. J Gerontol A Biol Sci Med Sci. 2012;67(10):1014-1021.

Jorgensen MJ, Rudel LL, Nudy M, Kaplan JR, Clarkson TB, Pajewski NM, Schnatz PF. 25(OH)D3 and cardiovascular risk factors in female nonhuman primates. J Womens Health. 2012;21(9):959-965.

Schnatz PF, Vila-Wright S, Jiang X, Register TC, Kaplan JR, Clarkson TB, Appt SE. The association between plasma 25-hydroxyvitamin D3 concentrations, C-reactive protein levels, and coronary artery atherosclerosis in postmenopausal monkeys. Menopause. 2012;19(10):1074-1080.

Schnatz PF, Nudy M, O'Sullivan DM, Jiang X, Cline JM, Kaplan JR, Clarkson TB, Appt SE. The quantification of vitamin D receptors in coronary arteries and their association with atherosclerosis. Maturitas. 2012;73(2):143-147.

Appt SE, Chen H, Clarkson TB, Kaplan JR. Premenopausal antimullerian hormone concentration is associated with subsequent atherosclerosis. Menopause. 2012;19(12):1353-1359.

Kavanagh K, Dozier BL, Chavanne TJ, Fairbanks LA, Jorgensen MJ, Kaplan JR. Fetal and maternal factors associated with infant mortality in vervet monkeys. J Med Primatol. 2011;40(1):27-36.

Hamilton RT, Rettberg JR, Mao Z, To J, Zhao L, Appt SE, Register TC, Kaplan JR, Brinton RD. Hippocampal responsiveness to 17 beta-estradiol and equol after long-term ovariectomy: implication for a therapeutic window of opportunity. Brain Res. 2011;1379():11-22.

Rettberg JR, Hamilton RT, Mao Z, To J, Zhao L, Appt SE, Register TC, Kaplan JR, Brinton RD. The effect of dietary soy isoflavones before and after ovariectomy on hippocampal protein markers of mitochondrial bioenergetics and antioxidant activity in female monkeys. Brain Res. 2011;1379():23-33.

Fairbanks LA, Bailey JN, Breidenthal SE, Laudenslager ML, Kaplan JR, Jorgensen MJ. Environmental stress alters genetic regulation of novelty seeking in vervet monkeys. Genes Brain Behav. 2011;10(6):683-688.

Fairbanks LA, Bailey JN, Breidenthal SE, Laudenslager ML, Kaplan JR, Jorgensen MJ. Environmental stress alters genetic regulation of novelty seeking in vervets [abstract]. Am J Primatol. 2011;73(Suppl 1):84.

Kuhrt D, Nusbaum R, Garlena R, Nguyen T, Jorgensen MJ, Silvestri G, Kaplan J, Apetrei C, Pandrea I. CCR5 expression on CD4+T cells and not CD4 downregulation impacts the efficacy of SIVagm mucosal transmission in African green monkeys (AGMS) [abstract]. J Med Primatol. 2011;40(4):256.

Voruganti V, Jorgensen MJ, Kaplan JR, Kauanagh K [sic] [Kavanagh K], Rudel LL, Temel R, Fairbanks LA, Comuzzie AG. Significant genotype by diet (GXD) interaction effects on cardiometabolic responses to a pedigree-wide, dietary challenge in Vervet monkeys (Chlorocebus aethiops sabaeus) [abstract]. Am J Primatol. 2011;73(Suppl 1):84.

Appt SE, Kavanagh K, Chen H, Kaplan JR, Lazar J, Clarkson TB. Pulse wave velocity is positively correlated with atherosclerosis extent in midlife female nonhuman primates [abstract]. Menopause. 2011;18(12):1348.

Jorgensen MJ, Schnatz PF, Rudel LL, Nudy M, Kaplan JR, Clarkson TB. Low plasma concentrations of vitamin D3 are associated with increased cardiovascular risk factors in a female nonhuman primate model [abstract]. Menopause. 2011;18(12):1345.

Schnatz PF, Vila-Wright S, Jiang X, Register TC, Appt SE, Kaplan JR, Clarkson TB. An inverse relationship between plasma vitamin D concentrations and C-reactive protein provides a potential mechanism for cardioprotection [abstract]. Menopause. 2011;18(12):1352.

Wood CE, Kaplan JR, Fontenot MB, Williams JK, Cline JM. Endometrial profile of tamoxifen and low-dose estradiol combination therapy. Clin Cancer Res. 2010;16(3):946-956.


Christ GJ, Melman A, Williams K, Aboushwareb T, Zhao WX, Kaplan J, Anderson K-E [sic] [Andersson K-E]. Nonhuman primates as a model for translational research on atherosclerosis-related vascular disease and erectile dysfunction [abstract]. J Sex Med. 2010;7(Suppl 1):46.

Appt SE, Chen H, Goode AK, Hoyer PB, Clarkson TB, Adams MR, Wilson ME, Franke AA, Kaplan JR. The effect of diet and cardiovascular risk on ovarian aging in cynomolgus monkeys (Macaca fascicularis). Menopause. 2010;17(4):741-748.

Appt SE, Clarkson TB, Hoyer PB, Kock ND, Goode AK, May MC, Persyn JT, Ethun KF, Chen H, Kaplan JR, et al. Experimental induction of reduced ovarian reserve in a nonhuman primate model (Macaca fascicularis). Comp Med. 2010;60(5):380-388.

Kaplan JR, Chen H, Appt SE, Lees CJ, Franke AA, Berga SL, Wilson ME, Manuck SB, Clarkson TB. Impairment of ovarian function and associated health-related abnormalities are attributable to low social status in premenopausal monkeys and not mitigated by a high-isoflavone soy diet. Hum Reprod. 2010;25(12):3083-3094.

Jolly CJ, Phillips-Conroy JE, Kaplan J, Bergman T, Mann JJ. Monoamine metabolites in the CSF of male anubis (Papio anubis) and hamadryas (P. hamadryas) baboons parallel their species-specific behavioral ontogeny [abstract]. Am J Phys Anthropol. 2009;138(Suppl 48):160-161.

Muhammad FS, Goode AK, Kock ND, Arifin EA, Cline JM, Adams MR, Hoyer PB, Christian PJ, Isom S, Kaplan JR, Appt SE. Effects of 4-vinylcyclohexene diepoxide on peripubertal and adult Sprague-Dawley rats: ovarian, clinical, and pathologic outcomes. Comp Med. 2009;59(1):46-59.

Riddick NV, Czoty PW, Gage HD, Kaplan JR, Nader SH, Icenhower M, Pierre PJ, Bennett A, Garg PK, Garg S, Nader MA. Behavioral and neurobiological characteristics influencing social hierarchy formation in female cynomolgus monkeys. Neuroscience. 2009;158(4):1257-1265.

Appt SE, Clarkson TB, Chen H, Adams MR, Christian PJ, Hoyer PB, Wilson ME, Kaplan JR. Serum antimullerian hormone predicts ovarian reserve in a monkey model. Menopause. 2009;16(3):597-601.

Appt SE, Clarkson TB, Chen H, Adams MR, Christian PJ, Hoyer PB, Wilson ME, Kaplan JR. Serum antimullerian hormone predicts ovarian reserve in a monkey model [abstract]. J Womens Health. 2009;18(5):744.

Wagner JD, Jorgensen MJ, Cline JM, Lees CJ, Franke AA, Zhang L, Ayers MR, Schultz C, Kaplan JR. Effects of soy vs. casein protein on body weight and glycemic control in female monkeys and their offspring. Am J Primatol. 2009;71(9):802-811.

Jolly CJ, Phillips-Conroy J, Kaplan J, Mann JJ. Monoamine metabolites in the CSF of male anubis (Papio anubis) and hamadryas (P. hamadryas) baboons parallel their species-specific behavioral ontogeny [abstract]. Am J Primatol. 2009;71(Suppl 1):64.


Christ GJ, Andersson K-E, Williams K, Zhao W, D'Agostino R Jr, Kaplan J, Aboushwareb T, Yoo J, Calenda G, Davies KP, et al. Smooth-muscle-specific gene transfer with the human Maxi-K channel improves erectile function and enhances sexual behavior in atherosclerotic cynomolgus monkeys. Eur Urol. 2009;56(6):1055-1066.

Chen Z, van Doorslaer K, DeSalle R, Wood CE, Kaplan JR, Wagner JD, Burk RD. Genomic diversity and interspecies host infection of alpha 12 Macaca fascicularis papillomaviruses (MfPVs). Virology. 2009;393(2):304-310.


Shively CA, Register TC, Kritchevsky S, Carr JJ, Kaplan JR, Jorgensen MJ, Bennett AJ. A primate model of physical function [abstract]. Gerontologist. 2009;49(Suppl 2):65-66.

Jarrell H, Hoffman JB, Kaplan JR, Berga S, Kinkead B, Wilson ME. Polymorphisms in the serotonin reuptake transporter gene modify the consequences of social status on metabolic health in female rhesus monkeys. Physiol Behav. 2008;93(4-5):807-819.

Christ GJ, Andersson K-E, Williams K, Zhao W, D'Agostino R, Kaplan J, Aboushwareb T, Yoo J, Davies K, Melman A. MAXI-K gene transfer with a smooth muscle specific promoter enhances erectile function and sexual behaviour in atherosclerotic cynomolgous monkeys [abstract]. Eur Urol. 2008;7(3 Suppl):143.

Gratzke C, Christ GJ, Kaplan JR, Stief CG, Andersson KE, Badlani G. Chronic soy and phytoestrogen treatment leads to significant functional and morphological changes in the urethra of oophorectomized female non-human primates [abstract]. Eur Urol. 2008;7(3 Suppl):315.

Gratzke C, Christ GJ, Kaplan JR, Andersson K-E, Badlani G. Chronic soy and phytoestrogen treatment leads to significant functional and morphological changes in the urethra of female non-human primates [abstract]. Neurourol Urodyn. 2008;27(2):106.

Miller-Butterworth CM, Kaplan JR, Shaffer J, Devlin B, Manuck SB, Ferrell RE. Sequence variation in the primate dopamine transporter gene and its relationship to social dominance. Mol Biol Evol. 2008;25(1):18-28.

Wagner JD, Zhang L, Shadoan MK, Kavanagh K, Chen H, Tresnasari K, Kaplan JR, Adams MR. Effects of soy protein and isoflavones on insulin resistance and adiponectin in male monkeys. Metabolism. 2008;57(Suppl 1):S24-S31.

Kaplan JR. Origins and health consequences of stress-induced ovarian dysfunction. Interdiscip Top Gerontol. 2008;36():162-185.

Kaplan JR, Manuck SB. Ovarian dysfunction and the premenopausal origins of coronary heart disease. Menopause. 2008;15(4 Pt 1):768-776.

Gratzke C, Jarajapu YPR, Christ GJ, Kaplan JR, Williams JK, Andersson K-E, Badlani G. Effects of long-term dietary soy treatment on female urethral morphology and function in ovariectomized nonhuman primates. J Urol. 2008;180(5):2247-2253.

Walker SE, Register TC, Appt SE, Adams MR, Clarkson TB, Chen H, Isom S, Franke AA, Kaplan JR. Plasma lipid-dependent and -independent effects of dietary soy protein and social status on atherogenesis in premenopausal monkeys: implications for postmenopausal atherosclerosis burden. Menopause. 2008;15(5):950-957.

Appt SE, Clarkson TB, Adams MR, Hoyer PB, Christian PJ, Kaplan JR. Dietary soy with isoflavones retards ovarian aging [abstract]. Menopause. 2008;15(6):1210.


Ethun K, Kavanagh K, Kaplan JR. Chronic experimental high-fat diet exposure leads to coagulopathy in African green monkeys (Chlorocebus aethiops saebeus) [abstract]. J Am Assoc Lab Anim Sci. 2008;47(5):108.

Pappano DJ, Ayers M, Cairnes D, May MC, Kaplan JR. Unrelated females housed in unisexual groups interfere in fights in a male-like pattern that is unassociated with affiliation and that tends to prolong aggressive encounters [abstract]. Am J Primatol. 2007;69(Suppl 1):31.

Kaplan J. What monkeys can teach us about the role of behavior and evolution in women's health [abstract]. Am J Primatol. 2007;69(Suppl 1):69.

Wagner JD, Zhang L, Kavanagh K, Gray SB, Adams MR, Kaplan JR. Effects of sex hormones and soy isoflavones on obesity and insulin resistance in cynomolgus monkeys [abstract]. Am J Primatol. 2007;69(Suppl 1):71.

Register TC, Walker SE, Shively CA, Adams MR, Kaplan JR, Appt SE, Clarkson TB. Inflammation and atherogenesis in female cynomolgus macaques (Macaca fascicularis) [abstract]. Am J Primatol. 2007;69(Suppl 1):72.

Appt SE, Kaplan JR, Clarkson TB, Hoyer PB. Modeling the perimenopausal transition [abstract]. Am J Primatol. 2007;69(Suppl 1):72-73.

Johnson Z, Lopez-Alvarenga JC, Brent L, Comuzzie AG, Mann JJ, Kaplan JR, Rogers J. Genetics of temperament in baboons (Papio hamadryas): strong heritability and linkage results from a factor analytical approach [abstract]. Am J Primatol. 2007;69(Suppl 1):86.

Riddick NV, Czoty PW, Kaplan JR, Pierre P, Bennett A, Gage HD, Nader MA. Behavioral and neurochemical measures as predictors of social rank in female monkeys [abstract]. FASEB J. 2007;21(6):A1179.

Lees CJ, Kaplan JR, Chen H, Jerome CP, Register TC, Franke AA. Bone mass and soy isoflavones in socially housed, premenopausal macaques. Am J Clin Nutr. 2007;86(1):245-250.

Jones JC, Appt SE, Bourland JD, Hoyer PB, Clarkson TB, Kaplan JR. Multidetector computed tomographic morphology of ovaries in cynomolgus macaques (Macaca fascicularis). J Am Assoc Lab Anim Sci. 2007;46(5):54-63.

Appt SE, Kaplan JR, Clarkson TB, Hoyer PB, Arifin E, Cline M, Isom S. Intramuscular administration of 4-vinylcyclohexene diepoxide (VCD) destroys primordial follicles in adult Sprague Dawley rats (Rattus norvegicus) [abstract]. J Am Assoc Lab Anim Sci. 2007;46(4):133-134.


Clarkson TB, Kaplan JR. Stage of reproductive life, atherosclerosis progression and estrogen effects on coronary artery atherosclerosis In: Lobo RA, ed. Treatment of the postmenopausal woman: basic and clinical aspects. 3rd ed. Burlington (MA): Academic Press;2007: 509-528.

Miller-Butterworth CM, Kaplan JR, Barmada MM, Manuck SB, Ferrell RE. The serotonin transporter: sequence variation in Macaca fascicularis and its relationship to dominance. Behav Genet. 2007;37(5):678-696.

Lees CJ, Chen H, Kaplan JR. Does pre- or post-menopausal soy consumption affect postmenopausal bone loss? [abstract]. J Bone Miner Res. 2007;22(Suppl 1):S431.

Kaplan JR. Primate models, cardiovascular disease In: Fink G, ed. Encyclopedia of stress, vol 3. 2nd ed. San Diego: Academic Press;2007: 204-210.

Stroud FC, Appt SE, Wilson ME, Franke AA, Adams MR,, Kaplan JR. Concentrations of isoflavones in macaques consuming standard laboratory monkey diet. J Am Assoc Lab Anim Sci. 2006;45(4):20-23.



Kaplan JR, Adams MR, Clarkson TB. Monkeys and the postmenopausal hormone therapy conundrum [abstract]. Am J Primatol. 2006;68(Suppl 1):39.

Miller-Butterworth CM, Kaplan JR, Manuck SB, Ferrell RE. Behavioral genetics of monoamine regulatory genes in the cynomolgus macaque [abstract]. Am J Primatol. 2006;68(Suppl 1):133-134.

Appt SE, Wood CE, Parker RC, Cline JM, Kaplan JR. Androgen production in the cynomolgus monkey ovary [abstract]. Menopause. 2006;13(6):989.

All Publications

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For a list of earlier publications, visit the Carpenter Library Publication Search.

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