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Jay R. Kaplan, Ph.D.Wake Forest School of Medicine

Jay R. Kaplan, Ph.D.

Shared Resource Director,
Director,


Professor,

Ctr for Vaccines at Extremes

Contact Information

Academic: 336-716-1522 | Department: 336-716-1522

Email: jkaplan@wakehealth.edu

Related Links

Education & Training

  • B.A., Swarthmore College, 1968
  • M.A., Northwestern University, 1970
  • Ph.D., Northwestern University, 1976

Memberships

  • Am Anthropological Assn
  • North Am Menopause Soc
  • Am Assn Of Physical Anthropolo
  • Acad for Beh Medicine Research
  • Am Soc Of Mammalogists
  • Aha - Council On Arteriosclero
  • Am Soc Of Primatologists
  • Am Soc Of Reproductive Med
Jay R. Kaplan, Ph.D.

Jay R. Kaplan, Ph.D.

Shared Resource Director, Translational Science Institute
Director, Center for Comparative Medicine Research

Pathology
Professor, Pathology-Comparative Medicine
Translational Science Institute
Ctr for Vaccines at Extremes

Research Interests

Macaca fascicularis; Isoflavones; Soybean Proteins; Ovary; Atherosclerosis
More »

Contact Information

Academic: 336-716-1522 | Department: 336-716-1522

Email: jkaplan@wakehealth.edu

Related Links

Recent Publications

Vitamin D heritability and effect of pregnancy status in vervet monkeys (Chlorocebus aethiops sabaeus) under conditions of modest and high dietary supplementation. Chittoor G, Pajewski NM, Voruganti VS, Comuzzie AG, Clarkson TB [deceased], Nudy M, Schnatz PF, Kaplan JR, Jorgensen MJ.. Am J Phys Anthropol. 2016;159(4):639-645.

Alterations in levels and ratios of n-3 and n-6 polyunsaturated fatty acids in the temporal cortex and liver of vervet monkeys from birth to early adulthood. Miller LR, Jorgensen MJ, Kaplan JR, Seeds MC, Rahbar E, Morgan TM, Welborn A, Chilton SM, Gillis J, Hester A, Rukstalis M, Sergeant S, Chilton FH.. Physiol Behav. 2016;156():71-78.

The aging vervet as a model of Alzheimer's disease [abstract]. Latimer C, Kaplan J, Shively C, Cline J, Andrews R, Jorgensen M, Craft S, Montine T, Keene C.. J Neuropathol Exp Neurol. 2016;75(6):604.

Beneficial effects of soy supplementation on postmenopausal atherosclerosis are dependent on pretreatment stage of plaque progression. Melendez GC, Register TC, Appt SE, Clarkson TB, Franke AA, Kaplan JR.. Menopause. 2015;22(3):289-296.

Genetic influences on response to novel objects and dimensions of personality in Papio baboons. Johnson Z, Brent L, Alvarenga JC, Comuzzie AG, Shelledy W, Ramirez S, Cox L, Mahaney MC, Huang YY, Mann JJ, Kaplan JR, Rogers J.. Behav Genet. 2015;45(2):215-227.

Structural variant discovery among related vervet monkeys [abstract]. Montague MJ, Hillier L, Jasinsk AJ, Turner T, Kaplan J, Jorgensen MJ, Freimer N, Weinstock G, Wilson RK, Warren WC.. Am J Phys Anthropol. 2015;156(Suppl 60):228.

Maternal effects influence the heritability of adult obesity traits but not obesogenic growth trajectories in vervet monkeys (Chlorocebus spp.) [abstract]. Schmitt CA, Service SK, Cantor RM, Jasinska AJ, Jorgensen MJ, Kaplan JR, Freimer NB.. Am J Phys Anthropol. 2015;156(Suppl 60):279.

Sequencing strategies and characterization of 721 vervet monkey genomes for future genetic analyses of medically relevant traits. Huang YS, Ramensky V, Service SK, Jasinska AJ, Jung Y, Choi OW, Cantor RM, Juretic N, Wasserscheid J, Kaplan JR, Jorgensen MJ, Dyer TD, Dewar K, Blangero J, Wilson RK, Warren W, Weinstock GM, Freimer NB.. BMC Biol. 2015;13():41.

Hematology and clinical chemistry measures during and after pregnancy and age- and sex-specific reference intervals in African green monkeys (Chlorocebus aethiops sabaeus). Chichester L, Gee MK, Jorgensen MJ, Kaplan JR.. J Am Assoc Lab Anim Sci. 2015;54(4):359-367.

Quantification 11C CIMBI-5, a 5-HT2AR agonist PET ligand in vervet monkey [abstract]. Prabhakaran J, DeLorenzo C, Pratap M, Jorgenson M, Kaplan JR, Knudsen G, Parsey R, Mann J, Kumar JSD.. J Nucl Med. 2015;56(3 Suppl 3):1558.

The genome of the vervet (Chlorocebus aethiops sabaeus). Warren WC, Jasinska AJ, Garcia-Perez R, Svardal H, Tomlinson C, Rocchi M, Archidiacono N, Capozzi O, Minx P, Montague MJ, Kyung K, Hillier LW, Kremitzki M, Graves T, Chiang C, Hughes J, Tran N, Huang Y, Ramensky V, Choi OW, Jung YJ, Schmitt CA,.. Genome Res. 2015;25(12):1921-1933.

The association between common iliac artery vitamin D receptor expression and atherosclerosis in postmenopausal nonhuman primates [abstract]. Nudy MS, Jiang XZ, Appt SE, O'Sullivan DM, Kaplan JR, Schnatz PF.. Menopause. 2015;22(12):1392.

Common iliac artery vitamin D receptor expression patterns during the development of atherosclerosis in postmenopausal nonhuman primates [abstract]. Jiang XZ, Nudy MS, Appt SE, O'Sullivan DM, Kaplan JR, Schnatz PF.. Menopause. 2015;22(12):1392.

Characterization of ovarian aging and reproductive senescence in vervet monkeys (Chlorocebus aethiops sabaeus). Atkins HM, Willson CJ, Silverstein M, Jorgensen M, Floyd E, Kaplan JR, Appt SE.. Comp Med. 2014;64(1):55-62.

Heritability of obesogenic growth trajectories during development in captive vervet monkeys (Chlorocebus aethiops sabaeus) [abstract]. Schmitt CA, Service S, Cantor RM, Jasinska AJ, Jorgensen MJ, Kaplan JR, Freimer NB.. Am J Phys Anthropol. 2014;153(Suppl 58):231-232.

The hair-diet C-13 and N-15 fractionation in Chlorocebus aethiops sabaeus based on a control diet study. Macharia AN, Cerling TE Jorgensen MJ, Kaplan JR.. Ann Zool Fennici. 2014;51(1-2):66-72.

Effect of soy isoflavones on thyroid hormones in intact and ovariectomized cynomolgus monkeys (Macaca fascicularis). Silverstein MG, Kaplan JR, Appt SE, Register TC, Shively CA.. Menopause. 2014;21(10):1136-1142.

High genetic heritability of obesogenic growth in captive vervet monkey (chlorocebus SPP) [abstract]. Schmitt CA, Service S, Cantor RM, Jasinska AJ, Jorgensen MJ, Kaplan JR, Freimer NB.. Am J Primatol. 2014;76(Suppl 1):74.

Genetics and development of obesity in captive vervet monkeys (Chlorocebus aethiops sabaeus) [abstract]. Schmitt CA, Service S, Cantor RM, Jasinska AJ, Jorgensen MJ, Kaplan JR, Freimer NB.. Am J Phys Anthropol. 2013;150(Suppl 56):243.

Monoamine neurotransmitter metabolites in the cerebrospinal fluid of a group of hybrid baboons (Papio hamadryas x P-anubis). Jolly CJ, Phillips-Conroy JE, Kaplan JR, Mann JJ.. Int J Primatol. 2013;34(4):836-858.

Development of amyloid burden in African Green monkeys. Kalinin S, Willard SL, Shively CA, Kaplan JR, Register TC, Jorgensen MJ, Polak PE, Rubinstein I, Feinstein DL.. Neurobiol Aging. 2013;34(10):2361-2369.

Significant genotype by diet (G X D) interaction effects on cardiometabolic responses to a pedigree-wide, dietary challenge in vervet monkeys (Chlorocebus aethiops sabaeus). Voruganti VS, Jorgensen MJ, Kaplan JR, Kavanagh K, Rudel LL, Temel R, Fairbanks LA, Comuzzie AG.. Am J Primatol. 2013;75(5):491-499.

Age-related degenerative functional, radiographic, and histological changes of the shoulder in nonhuman primates. Plate JF, Bates CM, Mannava S, Smith TL, Jorgensen MJ, Register TC, Stehle JR, High KP, Shively CA, Kaplan JR, Saul KR, Tuohy CJ.. J Shoulder Elbow Surg. 2013;22(8):1019-1029.

Systems biology of the vervet monkey. Jasinska AJ, Schmitt CA, Service SK, Cantor RM, Dewar K, Jentsch JD, Kaplan JR, Turner TR, Warren WC, Weinstock GM, Woods RP, Freimer NB.. ILAR J. 2013;54(2):122-143.

Premenopausal antimullerian hormone is a risk marker for postmenopausal coronary artery atherosclerosis progression in cynomolgus monkeys [abstract]. Appt SE, Kaplan JR, Clarkson TB.. Menopause. 2013;20(12):1324.

Effect of ovarian aging on androgen biosynthesis in a cynomolgus macaque model. Ethun KF, Wood CE, Parker CR, Kaplan JR, Chen H, Appt SE.. Climacteric. 2012;15(1):82-92.

Nonhuman primate models of atherosclerosis. Shelton KA, Clarkson TB, Kaplan JR. In: Abee CR, Mansfield K, Tardif S, Morris T, eds. Nonhuman primates in biomedical research, vol 2: diseases. 2nd ed. Boston: Elsevier Academic Press;2012: 385-411.

Hydrogen and oxygen isotope ratios in body water and hair: modeling isotope dynamics in nonhuman primates. O'Grady SP, Valenzuela LO, Remien CH, Enright LE, Jorgensen MJ, Kaplan JR, Wagner JD, Cerling TE, Ehleringer JR.. Am J Primatol. 2012;74(7):651-660.

Stimulatory adrenocortical effects of a selective estrogen receptor modulator in ovariectomized female macaques. Wood CE, Stavisky RC, Nowak J, Kaplan JR.. Toxicol Pathol. 2012;40(1):55-61.

Social dominance in female monkeys: dopamine receptor function and cocaine reinforcement. Nader MA, Nader SH, Czoty PW, Riddick NV, Gage HD, Gould RW, Blaylock BL, Kaplan JR, Garg PK, Davies HML, Morton D, Garg S, Reboussin BA.. Biol Psychiatry. 2012;72(5):414-421.

Coronary artery vitamin D receptor expression and plasma concentrations of 25-hydroxyvitamin D: their association with atherosclerosis. Schnatz PF, Nudy M, O'Sullivan DM, Jiang X, Cline JM, Kaplan JR, Clarkson TB, Appt SE.. Menopause. 2012;19(9):967-973.

The vervet research colony as a biomedical resource [abstract]. Jorgensen MJ, Rudel LL, Kavanagh K, Jasinska AJ, Freimer NB, Jentsch JD, Fairbanks LA, Fallon MT, Kaplan JR.. Am J Primatol. 2012;74(Suppl 1):68.

Aging does not reduce heat shock protein 70 in the absence of chronic insulin resistance. Kavanagh K, Wylie AT, Chavanne TJ, Jorgensen MJ, Voruganti VS, Comuzzie AG, Kaplan JR, McCall CE, Kritchevsky SB.. J Gerontol A Biol Sci Med Sci. 2012;67(10):1014-1021.

25(OH)D3 and cardiovascular risk factors in female nonhuman primates. Jorgensen MJ, Rudel LL, Nudy M, Kaplan JR, Clarkson TB, Pajewski NM, Schnatz PF.. J Womens Health. 2012;21(9):959-965.

The association between plasma 25-hydroxyvitamin D3 concentrations, C-reactive protein levels, and coronary artery atherosclerosis in postmenopausal monkeys. Schnatz PF, Vila-Wright S, Jiang X, Register TC, Kaplan JR, Clarkson TB, Appt SE.. Menopause. 2012;19(10):1074-1080.

The quantification of vitamin D receptors in coronary arteries and their association with atherosclerosis. Schnatz PF, Nudy M, O'Sullivan DM, Jiang X, Cline JM, Kaplan JR, Clarkson TB, Appt SE.. Maturitas. 2012;73(2):143-147.

Premenopausal antimullerian hormone concentration is associated with subsequent atherosclerosis. Appt SE, Chen H, Clarkson TB, Kaplan JR.. Menopause. 2012;19(12):1353-1359.

Fetal and maternal factors associated with infant mortality in vervet monkeys. Kavanagh K, Dozier BL, Chavanne TJ, Fairbanks LA, Jorgensen MJ, Kaplan JR.. J Med Primatol. 2011;40(1):27-36.

Hippocampal responsiveness to 17 beta-estradiol and equol after long-term ovariectomy: implication for a therapeutic window of opportunity. Hamilton RT, Rettberg JR, Mao Z, To J, Zhao L, Appt SE, Register TC, Kaplan JR, Brinton RD.. Brain Res. 2011;1379():11-22.

The effect of dietary soy isoflavones before and after ovariectomy on hippocampal protein markers of mitochondrial bioenergetics and antioxidant activity in female monkeys. Rettberg JR, Hamilton RT, Mao Z, To J, Zhao L, Appt SE, Register TC, Kaplan JR, Brinton RD.. Brain Res. 2011;1379():23-33.

Environmental stress alters genetic regulation of novelty seeking in vervet monkeys. Fairbanks LA, Bailey JN, Breidenthal SE, Laudenslager ML, Kaplan JR, Jorgensen MJ.. Genes Brain Behav. 2011;10(6):683-688.

Environmental stress alters genetic regulation of novelty seeking in vervets [abstract]. Fairbanks LA, Bailey JN, Breidenthal SE, Laudenslager ML, Kaplan JR, Jorgensen MJ.. Am J Primatol. 2011;73(Suppl 1):84.

CCR5 expression on CD4+T cells and not CD4 downregulation impacts the efficacy of SIVagm mucosal transmission in African green monkeys (AGMS) [abstract]. Kuhrt D, Nusbaum R, Garlena R, Nguyen T, Jorgensen MJ, Silvestri G, Kaplan J, Apetrei C, Pandrea I.. J Med Primatol. 2011;40(4):256.

Significant genotype by diet (GXD) interaction effects on cardiometabolic responses to a pedigree-wide, dietary challenge in Vervet monkeys (Chlorocebus aethiops sabaeus) [abstract]. Voruganti V, Jorgensen MJ, Kaplan JR, Kauanagh K [sic] [Kavanagh K], Rudel LL, Temel R, Fairbanks LA, Comuzzie AG.. Am J Primatol. 2011;73(Suppl 1):84.

Pulse wave velocity is positively correlated with atherosclerosis extent in midlife female nonhuman primates [abstract]. Appt SE, Kavanagh K, Chen H, Kaplan JR, Lazar J, Clarkson TB.. Menopause. 2011;18(12):1348.

Low plasma concentrations of vitamin D3 are associated with increased cardiovascular risk factors in a female nonhuman primate model [abstract]. Jorgensen MJ, Schnatz PF, Rudel LL, Nudy M, Kaplan JR, Clarkson TB.. Menopause. 2011;18(12):1345.

An inverse relationship between plasma vitamin D concentrations and C-reactive protein provides a potential mechanism for cardioprotection [abstract]. Schnatz PF, Vila-Wright S, Jiang X, Register TC, Appt SE, Kaplan JR, Clarkson TB.. Menopause. 2011;18(12):1352.

Endometrial profile of tamoxifen and low-dose estradiol combination therapy. Wood CE, Kaplan JR, Fontenot MB, Williams JK, Cline JM.. Clin Cancer Res. 2010;16(3):946-956.

Validation of multi-detector computed tomography as a non-invasive method for measuring ovarian volume in macaques (Macaca fascicularis). Jones JC, Appt SE, Werre SR, Tan JC, Kaplan JR.. Am J Primatol. 2010;72(6):530-538.

Nonhuman primates as a model for translational research on atherosclerosis-related vascular disease and erectile dysfunction [abstract]. Christ GJ, Melman A, Williams K, Aboushwareb T, Zhao WX, Kaplan J, Anderson K-E [sic] [Andersson K-E].. J Sex Med. 2010;7(Suppl 1):46.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Jay R. Kaplan, Ph.D.

Jay R. Kaplan, Ph.D.

Shared Resource Director, Translational Science Institute
Director, Center for Comparative Medicine Research

Pathology
Professor, Pathology-Comparative Medicine
Translational Science Institute
Ctr for Vaccines at Extremes

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