Profile

Kylie Kavanagh, D.V.M.Wake Forest School of Medicine

Kylie Kavanagh, D.V.M.

Associate Professor,


Contact Information

Academic: 336-715-1555 | Department: 336-713-1475

Email: kkavanag@wakehealth.edu

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Education & Training

  • B.S., Free Standing Institute-Australia, 1993
  • D.V.M., Free Standing Institute-Australia, 1996
  • M.S., University Of Melbourne-Australia, 1999
Kylie Kavanagh, D.V.M.

Kylie Kavanagh, D.V.M.

Associate Professor, Pathology-Comparative Medicine
Office of Women in Medicine and Science
Center on Diabetes, Obesity, and Metabolism

Research Interests

Liver; Fatty Liver; Fructose; Endotoxemia; Obesity
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Contact Information

Academic: 336-715-1555 | Department: 336-713-1475

Email: kkavanag@wakehealth.edu

Related Links

Recent Publications

Microbial translocation and skeletal muscle in young and old vervet monkeys. Kavanagh K, Brown RN, Davis AT, Uberseder B, Floyd E, Pfisterer B, Shively CA.. Age (Dordr). 2016;38(3):58.

Effects of heated hydrotherapy on muscle HSP70 and glucose metabolism in old and young vervet monkeys. Kavanagh K, Davis AT, Jenkins KA, Flynn DM.. Cell Stress Chaperones. 2016;21(4):717-725.

Late effects of total-body gamma irradiation on cardiac structure and function in male rhesus macaques. DeBo RJ, Lees CJ, Dugan GO, Caudell DL, Michalson KT, Hanbury DB, Kavanagh K, Cline JM, Register TC.. Radiat Res. 2016;186(1):55-64.

Muscle heat shock protein 70 predicts insulin resistance with aging. Chichester L, Wylie AT, Craft S, Kavanagh K.. J Gerontol A Biol Sci Med Sci. 2015;70(2):155-162.

Inducing muscle heat shock protein 70 improves insulin sensitivity and muscular performance in aged mice. Silverstein MG, Ordanes D, Wylie AT, Files DC, Milligan C, Presley TD, Kavanagh K.. J Gerontol A Biol Sci Med Sci. 2015;70(7):800-808.

Type 2 diabetes is a delayed late effect of whole-body irradiation in nonhuman primates. Kavanagh K, Dendinger MD, Davis AT, Register TC, DeBo R, Dugan G, Cline JM.. Radiat Res. 2015;183(4):398-406.

Reply to KN Litwak and S Levin [letter]. Kavanagh K, Wylie AT, Tucker KL, Hamp TJ, Gharaibeh RZ, Fodor AA, Cullen JM.. Am J Clin Nutr. 2014;99(1):210.

Dietary cholesterol promotes adipocyte hypertrophy and adipose tissue inflammation in visceral, but not in subcutaneous, fat in monkeys. Chung S, Cuffe H, Marshall SM, McDaniel AL, Ha JH, Kavanagh K, Hong C, Tontonoz P, Temel RE, Parks JS.. Arterioscler Thromb Vasc Biol. 2014;34(9):1880-1887.

The importance of the cellular stress response in the pathogenesis and treatment of type 2 diabetes. Hooper PL, Balogh G, Rivas E, Kavanagh K, Vigh L.. Cell Stress Chaperones. 2014;19(4):447-464.

Liver fat and SHBG affect insulin resistance in midlife women: the Study of Women's Health Across the Nation (SWAN). Kavanagh K, Espeland MA, Sutton-Tyrrell K, Barinas-Mitchell E, Khoudary SR, Wildman RP.. Obesity (Silver Spring). 2013;21(5):1031-1038.

Stearidonic and gamma-linolenic acids in echium oil improves glucose disposal in insulin resistant monkeys. Kavanagh K, Flynn DM, Jenkins KA, Wilson MD, Chilton FH.. Prostaglandins Leukot Essent Fatty Acids. 2013;89(1):39-45.

Dietary fructose induces endotoxemia and hepatic injury in calorically controlled primates. Kavanagh K, Wylie AT, Tucker KL, Hamp TJ, Gharaibeh RZ, Fodor AA, Cullen JM.. Am J Clin Nutr. 2013;98(2):349-357.

Significant genotype by diet (G X D) interaction effects on cardiometabolic responses to a pedigree-wide, dietary challenge in vervet monkeys (Chlorocebus aethiops sabaeus). Voruganti VS, Jorgensen MJ, Kaplan JR, Kavanagh K, Rudel LL, Temel R, Fairbanks LA, Comuzzie AG.. Am J Primatol. 2013;75(5):491-499.

Reply to JS White [Primate fructose study misses mark due to preventable design flaws] [reply to letter]. Kavanagh K, Wylie AT, Tucker KL, Hamp TJ, Gharaibeh RZ, Fodor AA, Cullen JM.. Am J Clin Nutr. 2013;98(5):1370.

The vervet research colony as a biomedical resource [abstract]. Jorgensen MJ, Rudel LL, Kavanagh K, Jasinska AJ, Freimer NB, Jentsch JD, Fairbanks LA, Fallon MT, Kaplan JR.. Am J Primatol. 2012;74(Suppl 1):68.

Aging does not reduce heat shock protein 70 in the absence of chronic insulin resistance. Kavanagh K, Wylie AT, Chavanne TJ, Jorgensen MJ, Voruganti VS, Comuzzie AG, Kaplan JR, McCall CE, Kritchevsky SB.. J Gerontol A Biol Sci Med Sci. 2012;67(10):1014-1021.

Fetal and maternal factors associated with infant mortality in vervet monkeys. Kavanagh K, Dozier BL, Chavanne TJ, Fairbanks LA, Jorgensen MJ, Kaplan JR.. J Med Primatol. 2011;40(1):27-36.

Ongoing beta-cell turnover in adult nonhuman primates is not adaptively increased in streptozotocin-induced diabetes. Saisho Y, Manesso E, Butler AE, Galasso R, Kavanagh K, Flynn M, Zhang L, Clark P, Gurlo T, Wagner JD, et al.. Diabetes. 2011;60(3):848-856.

Characterization and validation of a streptozotocin-induced diabetes model in the vervet monkey. Kavanagh K, Flynn DM, Nelson C, Zhang L, Wagner JD.. J Pharmacol Toxicol Methods. 2011;63(3):296-303.

Restoring HSP70 deficiencies improves glucose tolerance in diabetic monkeys. Kavanagh K, Flynn DM, Jenkins KA, Zhang L, Wagner JD.. Am J Physiol Endocrinol Metab. 2011;300(5):E894-E901.

Short-term hyperglycemia increases arterial superoxide production and iron dysregulation in atherosclerotic monkeys. Rowe PA, Kavanagh K, Zhang L, Harwood HJ Jr, Wagner JD.. Metabolism. 2011;60(8):1070-1080.

Significant genotype by diet (GXD) interaction effects on cardiometabolic responses to a pedigree-wide, dietary challenge in Vervet monkeys (Chlorocebus aethiops sabaeus) [abstract]. Voruganti V, Jorgensen MJ, Kaplan JR, Kauanagh K [sic] [Kavanagh K], Rudel LL, Temel R, Fairbanks LA, Comuzzie AG.. Am J Primatol. 2011;73(Suppl 1):84.

Pulse wave velocity is positively correlated with atherosclerosis extent in midlife female nonhuman primates [abstract]. Appt SE, Kavanagh K, Chen H, Kaplan JR, Lazar J, Clarkson TB.. Menopause. 2011;18(12):1348.

Relationship between fractional pancreatic beta cell area and fasting plasma glucose concentration in monkeys. Saisho Y, Butler AE, Manesso E, Galasso R, Zhang L, Gurlo T, Toffolo GM, Cobelli C, Kavanagh K, Wagner JD, et al.. Diabetologia. 2010;53(1):111-114.

Fluid compartmental shifts with efficacious pioglitazone therapy in overweight monkeys: implications for peroxisome proliferator-activated receptor-gamma agonist use in prediabetes. Kavanagh K, Brown KK, Berquist ML, Zhang L, Wagner JD.. Metabolism. 2010;59(6):914-920.

A selective peroxisome proliferator-activated receptor alpha agonist, CP-900691, improves plasma lipids, lipoproteins, and glycemic control in diabetic monkeys. Wagner JD, Shadoan MK, Zhang L, Ward GM, Royer LJ, Kavanagh K, Francone OL, Auerbach BJ, Harwood HJ Jr.. J Pharmacol Exp Ther. 2010;333(3):844-853.

Neonatal and fetal exposure to trans-fatty acids retards early growth and adiposity while adversely affecting glucose in mice. Kavanagh K, Sajadian S, Jenkins KA, Wilson MD, Carr JJ, Wagner JD, Rudel LL.. Nutr Res. 2010;30(6):418-426.

Clinicopathologic characterization of naturally occurring diabetes mellitus in vervet monkeys. Cann JA, Kavanagh K, Jorgensen MJ, Mohanan S, Howard TD, Gray SB, Hawkins GA, Fairbanks LA, Wagner JD.. Vet Pathol. 2010;47(4):713-718.

A selective cannabinoid-1 receptor antagonist, PF-95453, reduces body weight and body fat to a greater extent than pair-fed controls in obese monkeys. Wagner JD, Zhang L, Kavanagh K, Ward GM, Chin JE, Hadcock JR, Auerbach BJ, Harwood HJ Jr.. J Pharmacol Exp Ther. 2010;335(1):103-113.

Tissue-specific regulation and expression of heat shock proteins in type 2 diabetic monkeys. Kavanagh K, Zhang L, Wagner JD.. Cell Stress Chaperones. 2009;14(3):291-299.

Hepatic Mallory-Denk body formation in a streptozotocin-treated vervet monkey (Chlorocebus aethiops) [abstract]. Mohanan S, Wagner JD, Kock ND, Kavanagh K, Cline JM.. Toxicol Pathol. 2009;37(1):135-136.

Estrogen decreases atherosclerosis in part by reducing hepatic acyl-CoA: cholesterol acyltransferase 2 (ACAT2) in monkeys. Kavanagh K, Davis MA, Zhang L, Wilson MD, Register TC, Adams MR, Rudel LL, Wagner JD.. Arterioscler Thromb Vasc Biol. 2009;29(10):1471-1477.

Enhanced cholinergic response in pancreata of nonhuman primates with impaired glucose tolerance shown on [18F]fluorobenzyltrozamicol positron emission tomography. Clark PB, Kavanagh K, Gage HD, Garg P, Garg S, Calles-Escandon J, Wagner JD, Morton K.. Diabetes Technol Ther. 2009;11(7):451-455.

High isoflavone soy diet increases insulin secretion without decreasing insulin sensitivity in premenopausal nonhuman primates. Kavanagh K, Jones KL, Zhang L, Flynn DM, Shadoan MK, Wagner JD.. Nutr Res. 2008;28(6):368-376.

Chronic experimental high-fat diet exposure leads to coagulopathy in African green monkeys (Chlorocebus aethiops saebeus) [abstract]. Ethun K, Kavanagh K, Kaplan JR.. J Am Assoc Lab Anim Sci. 2008;47(5):108.

Addition of medroxyprogesterone acetate to conjugated equine estrogens results in insulin resistance in adipose tissue. Shadoan MK, Kavanagh K, Zhang L, Anthony MS, Wagner JD.. Metabolism. 2007;56(6):830-837.

Evaluation of pioglitazone induced fluid retention in primates [abstract]. Kavanagh K, Berquist M, Brown KK, Zhang L, Wagner JD.. Am J Primatol. 2007;69(Suppl 1):49.

Effects of sex hormones and soy isoflavones on obesity and insulin resistance in cynomolgus monkeys [abstract]. Wagner JD, Zhang L, Kavanagh K, Gray SB, Adams MR, Kaplan JR.. Am J Primatol. 2007;69(Suppl 1):71.

Trans fat diet induces abdominal obesity and changes in insulin sensitivity in monkeys. Kavanagh K, Jones KL, Sawyer J, Kelley K, Carr JJ, Wagner JD, Rudel LL.. Obesity. 2007;15(7):1675-1684.

Characterization and heritability of obesity and associated risk factors in vervet monkeys. Kavanagh K, Fairbanks LA, Bailey JN, Jorgensen MJ, Wilson M, Zhang L, Rudel LL, Wagner JD.. Obesity. 2007;15(7):1666-1674.

Development of a nonhuman primate model of type 1 diabetes in African green monkeys [abstract]. Flynn M, Kavanagh K, Zhang L, Collins J, Rankin S, Sajuthi A, Butler PC, Wagner JD.. J Am Assoc Lab Anim Sci. 2007;46(4):126.

Characterization of clinical and pancreatic islet pathology in captive, spontaneously diabetic Vervet monkeys (Chlorocebus aethiops) [abstract]. Gray SB, Cann JA, Trybus JA, Kavanagh K, Wagner JD.. J Am Assoc Lab Anim Sci. 2007;46(4):107.

Differential regulation of heat shock proteins in liver and pancreas of diabetic monkeys [abstract]. Kavanagh K, Zhang L, Wagner JD.. Diabetes. 2007;56(Suppl 1):A516.

A novel selective PPAR-alpha agonist, CP900691, improves plasma lipids, lipoproteins, glycemic control and reduces body weight in diabetic monkeys [abstract]. Flynn M, Shadoan MK, Kavanagh K, Zhang L, Auerbach BJ, Harwood HJ, Wagner JD.. Diabetes. 2007;56(Suppl 1):A138.

Stereotactic radiosurgery improves pre-treatment symptoms in patients with acoustic neuroma [abstract]. Powell, DF, Rossi PJ, Lawrence MV, Kavanagh K, McMullen KP, Stieber VW, Ellis TL, deGuzman AF, Bourland JD, Tatter SB.. Int J Radiat Oncol Biol Phys. 2006;66(3 Suppl):S198.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Pathology-Comparative Medicine

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