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Profile
Research

Kylie Kavanagh, D.V.M.

Assistant Professor, Pathology-Comparative Medicine
Translational Science Institute
Women's Health Center of Excellence for Research, Leadership, Education
Sticht Center on Aging
Center for Diabetes Research
WFU Primate Center
Center for Integrative Medicine
Translational Science Institute

Contact Information

Academic: 336-715-1555 | Department: 336-713-1475

Email: kkavanag@wakehealth.edu

Education & Training

B.S., Free Standing Institute-Australia , 1993
D.V.M., Free Standing Institute-Australia , 1996
M.S., University Of Melbourne-Australia , 1999

Kylie Kavanagh, D.V.M.

Assistant Professor, Pathology-Comparative Medicine Translational Science Institute
Women's Health Center of Excellence for Research, Leadership, Education
Sticht Center on Aging
Center for Diabetes Research
WFU Primate Center
Center for Integrative Medicine
Translational Science Institute

Research Interests

aging, diabetes, fitness/physical, metabolism, nutrition

Contact Information

Academic: 336-715-1555 | Department: 336-713-1475

Email: kkavanag@wakehealth.edu

Recent Publications

Jorgensen MJ, Rudel LL, Kavanagh K, Jasinska AJ, Freimer NB, Jentsch JD, Fairbanks LA, Fallon MT, Kaplan JR. The vervet research colony as a biomedical resource [abstract]. Am J Primatol. 2012;74(Suppl 1):68.

Kavanagh K, Wylie AT, Chavanne TJ, Jorgensen MJ, Voruganti VS, Comuzzie AG, Kaplan JR, McCall CE, Kritchevsky SB. Aging does not reduce heat shock protein 70 in the absence of chronic insulin resistance. J Gerontol A Biol Sci Med Sci. 2012;67(10):1014-1021.

Kavanagh K, Dozier BL, Chavanne TJ, Fairbanks LA, Jorgensen MJ, Kaplan JR. Fetal and maternal factors associated with infant mortality in vervet monkeys. J Med Primatol. 2011;40(1):27-36.

Saisho Y, Manesso E, Butler AE, Galasso R, Kavanagh K, Flynn M, Zhang L, Clark P, Gurlo T, Wagner JD, et al. Ongoing beta-cell turnover in adult nonhuman primates is not adaptively increased in streptozotocin-induced diabetes. Diabetes. 2011;60(3):848-856.

Kavanagh K, Flynn DM, Nelson C, Zhang L, Wagner JD. Characterization and validation of a streptozotocin-induced diabetes model in the vervet monkey. J Pharmacol Toxicol Methods. 2011;63(3):296-303.

Kavanagh K, Flynn DM, Jenkins KA, Zhang L, Wagner JD. Restoring HSP70 deficiencies improves glucose tolerance in diabetic monkeys. Am J Physiol Endocrinol Metab. 2011;300(5):E894-E901.

Rowe PA, Kavanagh K, Zhang L, Harwood HJ Jr, Wagner JD. Short-term hyperglycemia increases arterial superoxide production and iron dysregulation in atherosclerotic monkeys. Metabolism. 2011;60(8):1070-1080.

Voruganti V, Jorgensen MJ, Kaplan JR, Kauanagh K [sic] [Kavanagh K], Rudel LL, Temel R, Fairbanks LA, Comuzzie AG. Significant genotype by diet (GXD) interaction effects on cardiometabolic responses to a pedigree-wide, dietary challenge in Vervet monkeys (Chlorocebus aethiops sabaeus) [abstract]. Am J Primatol. 2011;73(Suppl 1):84.

Appt SE, Kavanagh K, Chen H, Kaplan JR, Lazar J, Clarkson TB. Pulse wave velocity is positively correlated with atherosclerosis extent in midlife female nonhuman primates [abstract]. Menopause. 2011;18(12):1348.

Saisho Y, Butler AE, Manesso E, Galasso R, Zhang L, Gurlo T, Toffolo GM, Cobelli C, Kavanagh K, Wagner JD, et al. Relationship between fractional pancreatic beta cell area and fasting plasma glucose concentration in monkeys. Diabetologia. 2010;53(1):111-114.

Kavanagh K, Brown KK, Berquist ML, Zhang L, Wagner JD. Fluid compartmental shifts with efficacious pioglitazone therapy in overweight monkeys: implications for peroxisome proliferator-activated receptor-gamma agonist use in prediabetes. Metabolism. 2010;59(6):914-920.

Wagner JD, Shadoan MK, Zhang L, Ward GM, Royer LJ, Kavanagh K, Francone OL, Auerbach BJ, Harwood HJ Jr. A selective peroxisome proliferator-activated receptor alpha agonist, CP-900691, improves plasma lipids, lipoproteins, and glycemic control in diabetic monkeys. J Pharmacol Exp Ther. 2010;333(3):844-853.

Kavanagh K, Sajadian S, Jenkins KA, Wilson MD, Carr JJ, Wagner JD, Rudel LL. Neonatal and fetal exposure to trans-fatty acids retards early growth and adiposity while adversely affecting glucose in mice. Nutr Res. 2010;30(6):418-426.

Cann JA, Kavanagh K, Jorgensen MJ, Mohanan S, Howard TD, Gray SB, Hawkins GA, Fairbanks LA, Wagner JD. Clinicopathologic characterization of naturally occurring diabetes mellitus in vervet monkeys. Vet Pathol. 2010;47(4):713-718.

Wagner JD, Zhang L, Kavanagh K, Ward GM, Chin JE, Hadcock JR, Auerbach BJ, Harwood HJ Jr. A selective cannabinoid-1 receptor antagonist, PF-95453, reduces body weight and body fat to a greater extent than pair-fed controls in obese monkeys. J Pharmacol Exp Ther. 2010;335(1):103-113.

Kavanagh K, Zhang L, Wagner JD. Tissue-specific regulation and expression of heat shock proteins in type 2 diabetic monkeys. Cell Stress Chaperones. 2009;14(3):291-299.

Mohanan S, Wagner JD, Kock ND, Kavanagh K, Cline JM. Hepatic Mallory-Denk body formation in a streptozotocin-treated vervet monkey (Chlorocebus aethiops) [abstract]. Toxicol Pathol. 2009;37(1):135-136.

Kavanagh K, Davis MA, Zhang L, Wilson MD, Register TC, Adams MR, Rudel LL, Wagner JD. Estrogen decreases atherosclerosis in part by reducing hepatic acyl-CoA: cholesterol acyltransferase 2 (ACAT2) in monkeys. Arterioscler Thromb Vasc Biol. 2009;29(10):1471-1477.

Clark PB, Kavanagh K, Gage HD, Garg P, Garg S, Calles-Escandon J, Wagner JD, Morton K. Enhanced cholinergic response in pancreata of nonhuman primates with impaired glucose tolerance shown on [18F]fluorobenzyltrozamicol positron emission tomography. Diabetes Technol Ther. 2009;11(7):451-455.

Kavanagh K, Jones KL, Zhang L, Flynn DM, Shadoan MK, Wagner JD. High isoflavone soy diet increases insulin secretion without decreasing insulin sensitivity in premenopausal nonhuman primates. Nutr Res. 2008;28(6):368-376.

Ethun K, Kavanagh K, Kaplan JR. Chronic experimental high-fat diet exposure leads to coagulopathy in African green monkeys (Chlorocebus aethiops saebeus) [abstract]. J Am Assoc Lab Anim Sci. 2008;47(5):108.

Shadoan MK, Kavanagh K, Zhang L, Anthony MS, Wagner JD. Addition of medroxyprogesterone acetate to conjugated equine estrogens results in insulin resistance in adipose tissue. Metabolism. 2007;56(6):830-837.

Kavanagh K, Berquist M, Brown KK, Zhang L, Wagner JD. Evaluation of pioglitazone induced fluid retention in primates [abstract]. Am J Primatol. 2007;69(Suppl 1):49.

Wagner JD, Zhang L, Kavanagh K, Gray SB, Adams MR, Kaplan JR. Effects of sex hormones and soy isoflavones on obesity and insulin resistance in cynomolgus monkeys [abstract]. Am J Primatol. 2007;69(Suppl 1):71.

Kavanagh K, Jones KL, Sawyer J, Kelley K, Carr JJ, Wagner JD, Rudel LL. Trans fat diet induces abdominal obesity and changes in insulin sensitivity in monkeys. Obesity. 2007;15(7):1675-1684.

Kavanagh K, Fairbanks LA, Bailey JN, Jorgensen MJ, Wilson M, Zhang L, Rudel LL, Wagner JD. Characterization and heritability of obesity and associated risk factors in vervet monkeys. Obesity. 2007;15(7):1666-1674.

Flynn M, Kavanagh K, Zhang L, Collins J, Rankin S, Sajuthi A, Butler PC, Wagner JD. Development of a nonhuman primate model of type 1 diabetes in African green monkeys [abstract]. J Am Assoc Lab Anim Sci. 2007;46(4):126.

Gray SB, Cann JA, Trybus JA, Kavanagh K, Wagner JD. Characterization of clinical and pancreatic islet pathology in captive, spontaneously diabetic Vervet monkeys (Chlorocebus aethiops) [abstract]. J Am Assoc Lab Anim Sci. 2007;46(4):107.

Kavanagh K, Zhang L, Wagner JD. Differential regulation of heat shock proteins in liver and pancreas of diabetic monkeys [abstract]. Diabetes. 2007;56(Suppl 1):A516.

Flynn M, Shadoan MK, Kavanagh K, Zhang L, Auerbach BJ, Harwood HJ, Wagner JD. A novel selective PPAR-alpha agonist, CP900691, improves plasma lipids, lipoproteins, glycemic control and reduces body weight in diabetic monkeys [abstract]. Diabetes. 2007;56(Suppl 1):A138.

Powell, DF, Rossi PJ, Lawrence MV, Kavanagh K, McMullen KP, Stieber VW, Ellis TL, deGuzman AF, Bourland JD, Tatter SB. Stereotactic radiosurgery improves pre-treatment symptoms in patients with acoustic neuroma [abstract]. Int J Radiat Oncol Biol Phys. 2006;66(3 Suppl):S198.