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Dalane W. Kitzman, M.D.Wake Forest School of Medicine

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Dalane W. Kitzman, M.D.

Professor,



Clinical Specialties

Heart Failure, Cardiac Imaging, Stress Testing, Diastolic Dysfunction, Cardiology (clinical), Echocardiography, Geriatric Medicine and Assessment

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New Patient Appointments: 336-716-WAKE
Returning Patient Appointments: 336-716-6674
Department: 336-716-3274

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Education & Training

  • B.A., Johns Hopkins University , 1981
  • M.D., Johns Hopkins University School of Medicine , 1984
  • Internship, Internal Medicine, Mayo Graduate School, 1985
  • Residency, Internal Medicine, Mayo Graduate School, 1987
  • Fellowship, Duke University Hospital, 1990

Board Certifications

  • American Board of Internal Medicine, Internal Medicine, Internal Medicine - Internal Medicine
  • American Board of Internal Medicine, Internal Medicine - Cardiovascular Disease

Memberships

  • Am Assn Of Clinical Anatomists
  • American College of Cardiology
  • Am Coll Of Physicians
  • Am Medical Assn
  • Am Soc Of Echocardiography
  • Am Soc Of Internal Medicine
  • Albemarle County Medical Socie
  • Forsyth Prepared Childbirth As

NPI Number

  • 1396720678
Dalane W. Kitzman, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

Dalane W. Kitzman, M.D.

Professor, Cardiology
Sticht Center on Aging
Gerontology and Geriatric Medicine
Translational Science Institute

Research Interests

aging, cardiac function, fitness/physical, hypertension, obesity, rehabilitation

Contact Information

Request An Appointment

Academic: 336-716-3274 | Department: 336-716-3274

Media Medical Expert »

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Recent Publications

Groban L, Kitzman DW, Register TC, Shively CA. Effect of depression and sertraline treatment on cardiac function in female nonhuman primates. Psychosom Med. 2014;76(2):137-146.

Ahmad T, Fiuzat M, Mark DB, Neely B, Neely M, Kraus WE, Kitzman DW, Whellan DJ, Donahue M, Zannad F, Pina IL, Adams K, O'Connor CM, Felker GM. The effects of exercise on cardiovascular biomarkers in patients with chronic heart failure. Am Heart J. 2014;167(2):193-202.

Shah AM, Cheng S, Skali H, Wu J, Mangion JR, Kitzman D, Matsushita K, Konety S, Butler KR, Fox ER, Cook N, Ni H, Coresh J, Mosley TH, Heiss G, Folsom AR, Solomon SD. Rationale and design of a multicenter echocardiographic study to assess the relationship between cardiac structure and function and heart failure risk in a biracial cohort of community-dwelling. Circ Cardiovasc Imaging. 2014;7(1):173-181.

Haykowsky MJ, Kouba EJ, Brubaker PH, Nicklas BJ, Eggebeen J, Kitzman DW. Skeletal muscle composition and its relation to exercise intolerance in older patients with heart failure and preserved ejection fraction. Am J Cardiol. 2014;113(7):1211-1216.


Patel K, Fonarow GC, Ekundayo OJ, Aban IB, Kilgore ML, Love TE, Kitzman DW, Gheorghiade M, Allman RM, Ahmed A. Beta-blockers in older patients with heart failure and preserved ejection fraction: class, dosage, and outcomes. Int J Cardiol. 2014;173(3):393-401.

Jordan JH, Haag JC, Morgan TM, Vasu S, Stacey B, Hamilton C, Robinson K, Kitzman D, Thohan V, Hundley WG. Small, short-duration, dobutamine-induced perfusion defects are not associated with adverse prognosis in intermediate-risk individuals receiving cardiovascular magnetic resonance stress imaging. J Comput Assist Tomogr. 2014;38(3):427-433.

Kitzman DW, Nicklas B, Kraus WE, Lyles MF, Eggebeen J, Morgan TM, Haykowsky M. Skeletal muscle abnormalities and exercise intolerance in older patients with heart failure and preserved ejection fraction. Am J Physiol Heart Circ Physiol. 2014;306(9):H1364-1370.

Brinkley TE, Leng X, Chughtai HL, Nicklas BJ, Kritchevsky SB, Ding J, Kitzman DW, Hundley WG. Periaortic fat and cardiovascular risk: a comparison of high-risk older adults and age-matched healthy controls. Int J Obes (Lond). 2014;():.

Ahmad T, Fiuzat M, Neely B, Neely ML, Pencina MJ, Kraus WE, Zannad F, Whellan DJ, Donahue MP, Pina IL, Adams KF, Kitzman DW, O'Connor CM, Felker GM. Biomarkers of myocardial stress and fibrosis as predictors of mode of death in patients with chronic heart failure. JACC Heart Fail. 2014;2(3):260-268.

Andersen MM, Kritchevsky SB, Morgan TM, Hire DG, Vasu S, Brinkley TE, Kitzman DW, Hamilton CA, Soots S, Hundley WG. Increased cardiovascular stiffness and impaired age-related functional status. J Gerontol A Biol Sci Med Sci. 2014;():.

Haykowsky MJ, Kitzman DW. Exercise physiology in heart failure and preserved ejection fraction. Heart Fail Clin. 2014;10(3):445-452.

Haykowsky MJ, Herrington DM, Brubaker PH, Morgan TM, Hundley WG, Kitzman DW. Relationship of flow-mediated arterial dilation and exercise capacity in older patients with heart failure and preserved ejection fraction. J Gerontol A Biol Sci Med Sci. 2013;68(2):161-167.

Kitzman DW, Herrington DM, Brubaker PH, Moore JB, Eggebeen J, Haykowsky MJ. Carotid arterial stiffness and its relationship to exercise intolerance in older patients with heart failure and preserved ejection fraction. Hypertension. 2013;61(1):112-119.


Mujib M, Patel K, Fonarow GC, Kitzman DW, Zhang Y, Aban IB, Ekundayo OJ, Love TE, Kilgore ML, Allman RM, Gheorghiade M, Ahmed A. Angiotensin-converting enzyme inhibitors and outcomes in heart failure and preserved ejection fraction. Am J Med. 2013;126(5):401-410.

Cheng CP, Cheng H-J, Zhou P, Li T-K, Kitzman DW, Kritchevsky SB, Little WC. Reversal of aging-induced contrast changes of cardiac SERCA 2a and inducible nitric oxide synthase in mice deficient in beta3-adrenoreceptor: insights into the molecular mechanism of cardiac aging [abstract]. Circ Res. 2013;113(4 Suppl):A087.

Dobre D, Zannad F, Keteyian SJ, Stevens SR, Rossignol P, Kitzman DW, Landzberg J, Howlett J, Kraus WE, Ellis SJ. Association between resting heart rate, chronotropic index, and long-term outcomes in patients with heart failure receiving beta-blocker therapy: data from the HF-ACTION trial. Eur Heart J. 2013;34(29):2271-2280.

Haykowsky MJ, Brubaker PH, Morgan TM, Kritchevsky S, Eggebeen J, Kitzman DW. Impaired aerobic capacity and physical functional performance in older heart failure patients with preserved ejection fraction: role of lean body mass. J Gerontol A Biol Sci Med Sci. 2013;68(8):968-975.

Kitzman DW, Brubaker PH, Herrington DM, Morgan TM, Stewart KP, Hundley WG, Abdelhamed A, Haykowsky MJ. Effect of endurance exercise training on endothelial function and arterial stiffness in older patients with heart failure and preserved ejection fraction: a randomized, controlled, single-blind trial. J Am Coll Cardiol. 2013;62(7):584-592.

McCullough PA, Barnard D, Clare R, Ellis SJ, Fleg JL, Fonarow GC, Franklin BA, Kilpatrick RD, Kitzman DW, O'Connor CM, Pina IL, Thadani U, Thohan V, Whellan DJ. Anemia and associated clinical outcomes in patients with heart failure due to reduced left ventricular systolic function. Clin Cardiol. 2013;36(10):611-620.

Patel K, Sui X, Zhang Y, Fonarow GC, Aban IB, Brown CJ, Bittner V, Kitzman DW, Allman RM, Banach M, Aronow WS, Anker SD, Blair SN, Ahmed A. Prevention of heart failure in older adults may require higher levels of physical activity than needed for other cardiovascular events. Int J Cardiol. 2013;168(3):1905-1909.

Tuttle M, Brubaker P, Eggebeen J, Kitzman D. The relationship between physical activity levels and physical function measures in acute decompensated heart failure patients [abstract]. Med Sci Sports Exerc. 2013;45(5 Suppl 1):648.

Ades PA, Keteyian SJ, Balady GJ, Houston-Miller N, Kitzman DW, Mancini DM, Rich MW. Cardiac rehabilitation exercise and self-care for chronic heart failure. JACC Heart Fail. 2013;1(6):540-547.

Agarwal SK, Liu XX, Wruck LM, Chang PP, Russell SD, Deswal A, Shah A, Fox E, Kitzman D, Soloman SD Coresh J, Heiss G, Rosamond W. Epidemiology of hospitalized heart failure patients with preserved ejection fraction: the ARIC Heart Failure Surveillance Project [abstract]. Circulation. 2013;127(12 Suppl):AMP03.

Brubaker PH, Kitzman DW. Chronotropy: the Cinderella of heart failure pathophysiology and management [editorial comment]. JACC Heart Fail. 2013;1(3):267-269.

Ahmad T, Fiuzat M, Stevens S, Schulte P, Kraus WE, Whellan D, Kitzman D, Zannad F, Pina I, Donahue M, Adams KF, Connor CO, Felker GM. Incremental prognostic utility by cost and complexity in chronic heart failure [abstract]. Circulation. 2013;128(22 Suppl):A16114.

Fleg JL, Forman DE, Berra K, Bittner V, Blumenthal JA, Chen MA, Cheng S, Kitzman DW, Maurer MS, Rich MW, Shen WK, Williams MA, Zieman SJ. Secondary prevention of atherosclerotic cardiovascular disease in older adults: a scientific statement from the American Heart Association. Circulation. 2013;128(22):2422-2446.

Patel K, Fonarow GC, Kitzman DW, Aban IB, Love TE, Allman RM, Gheorghiade M, Ahmed A. Aldosterone antagonists and outcomes in real-world older patients with heart failure and preserved ejection fraction. JACC Heart Fail. 2013;1(1):40-47.

Hummel SL, Kitzman DW. Update on heart failure with preserved ejection fraction. Curr Cardiovasc Risk Rep. 2013;7(6):495-502.

Gupta DK, Shah AM, Castagno D, Takeuchi M, Loehr LR, Fox ER, Butler KR, Mosley TH, Kitzman DW, Solomon SD. Heart failure with preserved ejection fraction in African Americans: the ARIC (Atherosclerosis Risk In Communities) study. JACC Heart Fail. 2013;1(2):156-163.

Felker GM, Fiuzat M, Thompson V, Shaw LK, Neely ML, Adams KF, Whellan DJ, Donahue MP, Ahmad T, Kitzman DW, Pina IL, Zannad F, Kraus WE, O'Connor CM. Soluble ST2 in ambulatory patients with heart failure: association with functional capacity and long-term outcomes. Circ Heart Fail. 2013;6(6):1172-1179.

Quarta CC, Buxbaum JN, Falk RH, Shah AM, Claggett B, Kitzmann D [sic] [Kitzman D], Mosely TH, Fox ERFR, Butler KR, Solomon SD. Cardiac structure and function and outcome of African-Americans carrying the amyloidogenic V122i transthyretin mutation: the ARIC (Atherosclerosis Risk in Communities) study [abstract]. Circulation. 2013;128(22 Suppl):A14903.

Vasu S, Morgan TM, Kitzman DW, Hamilton CA, Chiles C, Soots S, Thohan V, Hundley WG. Abnormal stress induced changes in arterial stiffness in middle aged men and women with impaired fasting glucose at risk of their first episode of symptomatic heart failure [abstract]. Circulation. 2013;128(22 Suppl):A18679.

Kitzman DW, Little WC. Left ventricle diastolic dysfunction and prognosis [editorial]. Circulation. 2012;125(6):743-745.

Felker GM, Fiuzat M, Shaw LK, Clare R, Whellan DJ, Bettari L, Shirolkar SC, Donahue M, Kitzman DW, Zannad F, Pina IL, O'Connor CM. Galectin-3 in ambulatory patients with heart failure: results from the HF-ACTION study. Circ Heart Fail. 2012;5(1):72-78.

O'Connor CM, Whellan DJ, Wojdyla D, Leifer E, Clare RM, Ellis SJ, Fine LJ, Fleg JL, Zannad F, Keteyian SJ, Kitzman DW, Kraus WE, Rendall D, Pina IL, Cooper LS, Fiuzat M, Lee KL. Factors related to morbidity and mortality in patients with chronic heart failure with systolic dysfunction: the HF-ACTION predictive risk score model. Circ Heart Fail. 2012;5(1):63-71.

Keteyian SJ, Kitzman D, Zannad F, Landzberg J, Arnold JM, Brubaker P, Brawner CA, Bensimhon D, Hellkamp AS, Ewald G. Predicting maximal HR in heart failure patients on beta-blockade therapy. Med Sci Sports Exerc. 2012;44(3):371-376.


Agarwal SK, Heiss G, Barr RG, Chang PP, Loehr LR, Chambless LE, Shahar E, Kitzman DW, Rosamond WD. Airflow obstruction, lung function, and risk of incident heart failure: the Atherosclerosis Risk in Communities (ARIC) study. Eur J Heart Fail. 2012;14(4):414-422.

Jeevanantham V, Chughtai H, Little WC, Morgan T, Kitzman DW, Hamilton CA, Hundley WG. Aging reduces left atrial performance during adrenergic stress in middle aged and older patients. Cardiol J. 2012;19(1):45-52.

Wilson V, Neiberg R, Tooze JA, Sink KM, Shea K, Williamson J, Kitzman DW, Hausman DB, Cauley J, Bauer D, Harris T, Kritchevsky SB, Houston DK. 25-hydroxyvitamin D and cardiovascular disease in the Health ABC Study [abstract]. J Am Geriatr Soc. 2012;60(Suppl 4):S89.

Bertoni AG, Wagenknecht LE, Kitzman DW, Marcovina SM, Rushing JT, Espeland MA. Impact of the Look AHEAD intervention on NT-pro brain natriuretic peptide in overweight and obese adults with diabetes. Obesity (Silver Spring). 2012;20(7):1511-1518.


Murad K, Brubaker PH, Fitzgerald DM, Morgan TM, Goff DC Jr, Soliman EZ, Eggebeen JD, Kitzman DW. Exercise training improves heart rate variability in older patients with heart failure: a randomized, controlled, single-blinded trial. Congest Heart Fail. 2012;18(4):192-197.


Haykowsky MJ, Brubaker PH, Stewart KP, Morgan TM, Eggebeen J, Kitzman DW. Effect of endurance training on the determinants of peak exercise oxygen consumption in elderly patients with stable compensated heart failure and preserved ejection fraction. J Am Coll Cardiol. 2012;60(2):120-128.

Shively CA, Willard SL, Register TC, Bennett AJ, Pierre PJ, Laudenslager ML, Kitzman DW, Childers MK, Grange RW, Kritchevsky SB. Aging and physical mobility in group-housed Old World monkeys. Age (Dordr). 2012;34(5):1123-1131.

Girotra S, Kitzman DW, Kop WJ, Stein PK, Gottdiener JS, Mukamal KJ. Heart rate response to a timed walk and cardiovascular outcomes in older adults: the Cardiovascular Health Study. Cardiology. 2012;122(2):69-75.

Gupta DK, Shah AM, Castagno D, Takeuchi M, Loehr LR, Fox E, Butler KR, Mosley TH, Kitzman DW, Solomon SD. Heart failure and preserved ejection fraction in African-Americans: the ARIC study [abstract]. J Card Fail. 2012;18(8 Suppl 1):S65.

Mentz RJ, Schulte PJ, Kitzman DW, Fiuzat M, Kraus WE, Pina IL, Keteyian SJ, Fleg JL, Ellis SJ, Whellan DJ, O'Connor CM. Beta-blocker selectivity in heart failure (HF) patients with chronic obstructive pulmonary disease (COPD): insights from HF-A controlled trial investigating outcomes of exercise training (HF-ACTION) [abstract]. J Card Fail. 2012;18(8 Suppl 1):S63.

Reeves GR, Patel MJ, Whellan DJ, O'Connor CM, Eggebeen JD, Duncan P, Hewston LA, Pastva A, Adams S, Thohan V, Kitzman DW. Elderly hospitalized heart failure patients have profound impairments in physical function [abstract]. J Card Fail. 2012;18(8 Suppl 1):S98.

Neiberg RH, Wing RR, Bray GA, Reboussin DM, Rickman AD, Johnson KC, Kitabchi AE, Faulconbridge LF, Kitzman DW, Espeland MA. Patterns of weight change associated with long-term weight change and cardiovascular disease risk factors in the Look AHEAD Study. Obesity (Silver Spring). 2012;20(10):2048-2056.

Cheng H-J, Zhou P, Shao Q, Kitzman DW, Kritchevsky SB, Sane DC, Little WC, Cheng CP. Upregulation of cardiac beta3-adrenergic receptor-activated inducible nitric oxide synthase promotes cardiac aging: role of oxidant stress [abstract]. Circulation. 2012;126(21 Suppl):A11645.

Gardin JM, Leifer ES, Kitzman DW, Cohen G, Landzberg JS, Cotts W, Wolfel EE, Safford RE, Bess RL, Fleg JL. Usefulness of Doppler echocardiographic left ventricular diastolic function and peak exercise oxygen consumption to predict cardiovascular outcomes in patients with systolic heart failure (from HF-ACTION). Am J Cardiol. 2012;110(6):862-869.

Patel K, Fonarow GC, Kitzman DW, Aban IB, Love TE, Allman RM, Gheorghiade M, Ahmed A. Angiotensin receptor blockers and outcomes in real-world older patients with heart failure and preserved ejection fraction: a propensity-matched inception cohort clinical effectiveness study. Eur J Heart Fail. 2012;14(10):1179-1188.

Devereux RB, de Simone G, Arnett DK, Best LG, Boerwinkle E, Howard BV, Kitzman D, Lee ET, Mosley TH Jr, Weder A, Roman MJ. Normal limits in relation to age, body size and gender of two-dimensional echocardiographic aortic root dimensions in persons greater than or equal to 15 years of age. Am J Cardiol. 2012;110(8):1189-1194.

Guazzi M, Adams V, Conraads V, Halle M, Mezzani A, Vanhees L, Arena R, Fletcher GF, Forman DE, Kitzman DW, Lavie CJ, Myers J. Clinical recommendations for cardiopulmonary exercise testing data assessment in specific patient populations. Circulation. 2012;126(18):2261-2274.

Keteyian SJ, Leifer ES, Houston-Miller N, Kraus WE, Brawner CA, O'Connor CM, Whellan DJ, Cooper LS, Fleg JL, Kitzman DW, Cohen-Solal A, Blumenthal JA, Rendall DS, Pina IL. Relation between volume of exercise and clinical outcomes in patients with heart failure. J Am Coll Cardiol. 2012;60(19):1899-1905.

Stehle JR Jr, Leng X, Kitzman DW, Nicklas BJ, Kritchevsky SB, High KP. Lipopolysaccharide-binding protein, a surrogate marker of microbial translocation, is associated with physical function in healthy older adults. J Gerontol A Biol Sci Med Sci. 2012;67(11):1212-1218.

Clevenger D, Brubaker PH, Eggebeen J, Kitzman DW. Effects of exercise training on objectively measured physical activity levels in heart failure patients [abstract]. Med Sci Sports Exerc. 2012;44(Suppl 2):294.

Guazzi M, Adams V, Conraads V, Halle M, Mezzani A, Vanhees L, Arena R, Fletcher GF, Forman DE, Kitzman DW, Lavie CJ, Myers J. Clinical recommendations for cardiopulmonary exercise testing data assessment in specific patient populations. Eur Heart J. 2012;33(23):2917-2927.

Ribisl PM, Gaussoin SA, Lang W, Bahnson J, Connelly SA, Horton ES, Jakicic JM, Killean T, Kitzman DW, Knowler WC, Stewart KJ. Lifestyle intervention improves heart rate recovery from exercise in adults with type 2 diabetes: results from the Look AHEAD study. J Obes. 2012;2012():309196.

Forman DE, Fleg JL, Kitzman DW, Brawner CA, Swank AM, McKelvie RS, Clare RM, Ellis SJ, Dunlap ME, Bittner V. 6-min walk test provides prognostic utility comparable to cardiopulmonary exercise testing in ambulatory outpatients with systolic heart failure. J Am Coll Cardiol. 2012;60(25):2653-2661.

Scott JM, Haykowsky MJ, Eggebeen J, Morgan TM, Brubaker PH, Kitzman DW. Reliability of peak exercise testing in patients with heart failure with preserved ejection fraction. Am J Cardiol. 2012;110(12):1809-1813.

Lam CS, Carson PE, Anand IS, Rector TS, Kuskowski M, Komajda M, McKelvie RS, McMurray JJ, Zile MR, Massie BM, Kitzman DW. Sex differences in clinical characteristics and outcomes in elderly patients with heart failure and preserved ejection fraction: the Irbesartan in Heart Failure with Preserved Ejection Fraction (I-PRESERVE) trial. Circ Heart Fail. 2012;5(5):571-578.

Brinkley TE, Kitzman DW, Ding J, Nicklas BJ, Kritchevsky SB, Hundley WG. Epicardial, pericardial and periaortic fat are elevated in older adults at high cardiac risk [abstract]. Arterioscler Thromb Vasc Biol. 2012;32(5 Suppl):A132.

Brubaker PH, Kitzman DW. Chronotropic incompetence: causes, consequences, and management. Circulation. 2011;123(9):1010-1020.



Atchley AE, Iskandrian AE, Bensimhon D, Ellis SJ, Kitzman DW, Shaw LK, Pagnanelli RA, Whellan DJ, Gardin JM, Kao A, et al. Relationship of technetium-99m tetrofosmin-gated rest single-photon emission computed tomography myocardial perfusion imaging to death and hospitalization in heart failure patients:. Am Heart J. 2011;161(6):1038-1045.

Haykowsky MJ, Brubaker PH, John JM, Stewart KP, Morgan TM, Kitzman DW. Determinants of exercise intolerance in elderly heart failure patients with preserved ejection fraction. J Am Coll Cardiol. 2011;58(3):265-274.

Shea MK, Nicklas BJ, Houston DK, Miller ME, Davis CC, Kitzman DW, Espeland MA, Appel LJ, Kritchevsky SB. The effect of intentional weight loss on all-cause mortality in older adults: results of a randomized controlled weight-loss trial. Am J Clin Nutr. 2011;94(3):839-846.


Kitzman DW, Groban L. Exercise intolerance. Cardiol Clin. 2011;29(3):461-477.

Willard SL, Register TC, Bennett AJ, Pierre PJ, Laudenslager ML, Kitzman DW, Childers MK, Grange RW, Kritschevsky SB [sic] [Kritchevsky SB], Shively CA. Developing models of aging and physical function in three species of old world monkeys [abstract]. Am J Primatol. 2011;73(Suppl 1):81.

Arena R, Myers J, Abella J, Pinkstaff S, Brubaker P, Kitzman DW, Peberdy MA, Bensimhon D, Chase P, Guazzi M. Cardiopulmonary exercise testing is equally prognostic in young, middle-aged and older individuals diagnosed with heart failure. Int J Cardiol. 2011;151(3):278-283.


Barasch E, Gottdiener JS, Aurigemma G, Kitzman DW, Han J, Kop WJ, Tracy RP. The relationship between serum markers of collagen turnover and cardiovascular outcome in the elderly: the Cardiovascular Health Study. Circ Heart Fail. 2011;4(6):733-739.

Horwich TB, Broderick S, Chen L, McCullough PA, Strzelczyk T, Kitzman DW, Fletcher G, Saffford RE, Ewald G, Fine LJ, Ellis SJ, Fonarow GC. Relation among body mass index, exercise training, and outcomes in chronic systolic heart failure. Am J Cardiol. 2011;108(12):1754-1759.

Kitzman DW, Morgan T, Haykowsky M, Brubaker P. Determinants of exercise intolerance in heart failure with preserved ejection fraction [reply to letter]. J Am Coll Cardiol. 2011;58(24):2548-2549.

Deng H, Kitzman D, Hundley G, Hoyle J, Wells G, Burgess P, Ohara T, Meng M, Kon N, Pu M. What is the best method to assess mitral valvular obstruction after mitral annuloplasty? [abstract]. J Am Coll Cardiol. 2011;57(14 Suppl 1):E1352.

Ahmed A, Zhang Y, Mujib M, Arora T, Kilgore M, Aban I, Love T, Levesque R, Kitzman D, Gheorghiade M, Allman R, Fonarow G. Lack of association between discharge prescription of aldosterone antagonists and outcomes in Medicare beneficiaries with heart failure and preserved ejection fraction: a propensity-matched study of the OPTIMIZE-HF [abstract]. Circulation. 2011;124(21 Suppl):A8493.

Fiuzat M, Wojdyla D, Whellan D, Chiswell K, Kitzman D, Kraus W, Keteyian S, Patterson H, Adams K, Fleg J, Pina I, O'Connor CM. Relationship of beta-blocker (BB) dose with outcomes in ambulatory heart failure (HF) patients with systolic dysfunction: results from the HF-ACTION Trial [abstract]. Circulation. 2011;124(21 Suppl):A12023.

Forman DE, Fleg J, Kitzman D, Brawner C, Swank A, McKelvie R, Clare R, Ellis S, Dunlap M, Bittner V. Does the 6 minute walk test provide useful prognostic information in systolic heart failure patients? [abstract]. Circulation. 2011;124(21 Suppl):A16348.

Gardin JM, Kitzman DW, Leifer ES, Cohen G, Landzberg JS, Cotts WG, Wolfel EE, Safford RE, Bess RL, Fleg JL. Left ventricular diastolic function and peak exercise oxygen consumption contribute independently to predicting clinical outcomes in patients with systolic heart failure in heart failure:. Circulation. 2011;124(21 Suppl):A16091.

Lam CS, Anand IS, Carson PE, Massie BM, Rector TS, Kuskowski M, McKelvie RS, Zile MR, McMurray JJ, Komajda M, Kitzman DW. Sex differences in clinical characteristics and outcomes in elderly patients with heart failure and preserved ejection fraction: the I-PRESERVE Trial [abstract]. Circulation. 2011;124(21 Suppl):A10912.

Stehle JR, Nicklas B, Kritchevsky SB, Kitzman DW, Leng X, High K. Association between microbial translocation and adiposity in healthy elderly adults [abstract]. Gerontologist. 2011;51(Suppl 2):490.

Groban L, Kitzman DW. Diastolic function: a barometer for cardiovascular risk? [editorial]. Anesthesiology. 2010;112(6):1303-1306.

Shea MK, Houston DK, Nicklas BJ, Messier SP, Davis CC, Miller ME, Harris TB, Kitzman DW, Kennedy K, Kritchevsky SB. The effect of randomization to weight loss on total mortality in older overweight and obese adults: the ADAPT Study. J Gerontol A Biol Sci Med Sci. 2010;65(5):519-525.



Arena R, Myers J, Abella J, Pinkstaff S, Brubaker P, Kitzman D, Peberdy MA, Bensimhon D, Chase P, Forman DE, et al. Defining the optimal prognostic window for cardiopulmonary exercise testing in patients with heart failure. Circ Heart Fail. 2010;3(3):405-411.

Kitzman DW, Hundley WG, Brubaker PH, Morgan TM, Moore JB, Stewart KP, Little WC. A randomized double-blind trial of enalapril in older patients with heart failure and preserved ejection fraction: effects on exercise tolerance and arterial distensibility. Circ Heart Fail. 2010;3(4):477-485.

Arena R, Myers J, Abella J, Pinkstaff S, Brubaker P, Kitzman D, Perberdy MA, Bensimhon D, Chase P, Guazzi M. Prognostic significance of the oxygen uptake efficiency slope: percent-predicted versus actual value [letter]. Am J Cardiol. 2010;105(5):757-758.

Kitzman DW, Brubaker PH, Morgan TM, Stewart KP, Little WC. Exercise training in older patients with heart failure and preserved ejection fraction: a randomized, controlled, single-blind trial. Circ Heart Fail. 2010;3(6):659-667.

Cheng H-J, Zhou P, Kitzman DW, Kritchevsky SB, Sane DC, Little WC, Cheng C-P. Reversal of aging-induced upregulation of cardiac inducible nitric oxide synthase and beta-adrenergic desensitization in mice lacking the beta3-adrenoreceptor [abstract]. Circulation. 2010;122(21 Suppl):A13008.


Kitzman DW, Rich MW. Age disparities in heart failure research [commentary]. JAMA. 2010;304(17):1950-1951.

Murad K, Soliman EZ, Morgan TM, Fitzgerald DM, Eggebeen JD, Goff DC, Kitzman DW. Exercise training improves heart rate variability in older patients with heart failure. A randomized, controlled, single-blinded study [abstract]. J Card Fail. 2010;16(8 Suppl 1):S67.

Pitt B, Huang IZ, Anker S, Bushinsky D, Kitzman D, Zannad F. The PEARL HF (multicenter randomized double blind placebo controlled, parallel group multiple dose to evaluate the effects of RLY5016 in heart failure patients) Trial [abstract]. J Card Fail. 2010;16(11):912.

Felker GM, Fiuzat M, Shaw LK, Donahue M, Adams KF, Zannad F, Whellan D, Kitzman D, Pina I, O'connor CM. Prognostic value of Galectin-3 in chronic heart failure: results from the HF-ACTION Study [abstract]. Eur Heart J. 2010;31(Suppl 1):429.

John JM, Haykowsky M, Brubaker P, Stewart K, Kitzman DW. Decreased left ventricular distensibility in response to postural change in older patients with heart failure and preserved ejection fraction. Am J Physiol Heart Circ Physiol. 2010;299(3):H883-889.

Brinkley TE, Leng X, Miller ME, Kitzman DW, Pahor M, Berry MJ, Marsh AP, Kritchevsky SB, Nicklas BJ. Chronic inflammation is associated with low physical function in older adults across multiple comorbidities. J Gerontol A Biol Sci Med Sci. 2009;64(4):455-461.

Hartmann EL, Kitzman D, Rocco M, Leng X, Klepin H, Gordon M, Rejeski J, Berry M, Kritchevsky S. Physical function in older candidates for renal transplantation: an impaired population. Clin J Am Soc Nephrol. 2009;4(3):588-594.

Kitzman DW, Taffet G. Effects of aging on cardiovascular structure and function In: Halter JB, Ouslander JG, Tinetti ME, Studenski S, High KP, Asthana S, Hazzard WR, Wollard NF, eds. Hazzard's geriatric medicine and gerontology. 6th ed. New York: McGraw Hill Medical;2009: 883-895.

Agarwal SK, Loehr L, Shahar E, Kitzman DW, Wood JL, Punjabi N, Heiss G. Lung function and incident hospitalized heart failure: the Atherosclerosis Risk in Communities (ARIC) Study [abstract]. Circulation. 2009;119(10):e283.


Flynn KE, Pina IL, Whellan DJ, Lin L, Blumenthal JA, Ellis SJ, Fine LJ, Howlett JG, Keteyian SJ, Kitzman DW, et al. Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA. 2009;301(14):1451-1459.

O'Connor CM, Whellan DJ, Lee KL, Keteyian SJ, Cooper LS, Ellis SJ, Leifer ES, Kraus WE, Kitzman DW, Blumenthal JA, et al. Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA. 2009;301(14):1439-1450.

Shea MK, Davis CC, Nicklas BJ, Kitzman DW, Miller ME, Kennedy K, Kritchevsky SB. The effect of intentional weight-loss on total mortality in older adults [abstract]. J Am Geriatr Soc. 2009;57(Suppl 1):S122.

Arena R, Myers J, Abella J, Pinkstaff S, Brubaker P, Moore B, Kitzman D, Peberdy MA, Bensimhon D, Chase P, et al. Determining the preferred percent-predicted equation for peak oxygen consumption in patients with heart failure. Circ Heart Fail. 2009;2(2):113-120.

Tang W, Devereux RB, Li N, Oberman A, Kitzman DW, Rao DC, Kopkins PN, Claas SA, Arnett DK. Identification of a pleiotropic locus on chromosome 7q for a composite left ventricular wall thickness factor and body mass index: the HyperGEN Study. BMC Med Genet. 2009;10():article 40.

Aurigemma GP, Gottdiener JS, Arnold AM, Chinali M, Hill JC, Kitzman D. Left atrial volume and geometry in healthy aging: the Cardiovascular Health Study. Circ Cardiovasc Imaging. 2009;2(4):282-289.

Barasch E, Goadiener JS, Aurigemma G, Kitzman DW, Han J, Kop WJ, Tracy RP. Association between elevated fibrosis markers and heart failure in the elderly: the Cardiovascular Health Study. Circ Heart Fail. 2009;2(4):303-310.

Walsh TF, Dall'Armellina E, Chughtai H, Morgan TM, Ntim W, Link KM, Hamilton CA, Kitzman DW, Hundley WG. Adverse effect of increased left ventricular wall thickness on five year outcomes of patients with negative dobutamine stress. J Cardiovasc Magn Reson. 2009;11():article 25.

Oliveira RB, Myers J, Araujo CGS, Arena R, Mandic S, Bensimhon D, Abella J, Chase P, Guazzi M, Kitzman D, et al. Does peak oxygen pulse complement peak oxygen uptake in risk stratifying patients with heart failure?. Am J Cardiol. 2009;104(4):554-558.

Puntawagkoon C, Kitzman DW, Kritchevsky SB, Hamilton CA, Nicklas B, Leng X, Brubaker PH, Hundley WG. Exercise limb blood flow is reduced despite adequate cardiac output in elderly patients with heart failure [abstract]. J Card Fail. 2009;15(6 Suppl 1):S69.

Whellan DJ, Ellis SJ, Kraus WE, Hawthorne K, Pina IL, Keteyian SJ, Kitzman DW, Cooper L, Lee K, O'Connor CM. Method for establishing authorship in a multicenter clinical trial. Ann Intern Med. 2009;151(6):414-420.

Cheng H-J, Zhou P, Cross M, Kitzman D, Kritchevsky S, Sane DC, Little WC, Cheng C-P. Upregulation of cardiac SERCA 2a by chronic beta3-adrenergic receptor (AR) deficiency: a key molecular mechanism of the protective effect of beta3-AR deficiency on myocardial aging [abstract]. Circulation. 2009;120(18 Suppl):S584-S585.

Jeevanantham V, Chughtai HL, Little WC, Morgan TM, Kitzman DW, Ntim WO, Hamilton CA, Hundley WG. Aging affects the response of the left atrium to adrenergic stress [abstract]. Circulation. 2009;120(18 Suppl):S493.

Arena R, Myers J, Abella J, Pinkstaff S, Brubaker P, Moore B, Kitzman D, Peberdy MA, Bensimhon D, Chase P, et al. Influence of etiology of heart failure on the obesity paradox. Am J Cardiol. 2009;104(8):1116-1121.

Atchley AE, Kitzman DW, Whellan DJ, Iskandrian AE, Ellis SJ, Pagnanelli RA, Kao A, Abdul-Nour K, O'Connor CM, Ewald G, et al. Myocardial perfusion, function, and dyssynchrony in patients with heart failure: baseline results from the single-photon emission computed tomography imaging ancillary study of the Heart. Am Heart J. 2009;158(4 Suppl 1):S53-S63.


Brubaker PH, Moore JB, Stewart KP, Wesley DJ, Kitzman DW. Endurance exercise training in older patients with heart failure: results from a randomized, controlled, single-blind trial. J Am Geriatr Soc. 2009;57(11):1982-1989.

Forman DE, Clare R, Kitzman DW, Ellis SJ, Fleg JL, Chiara T, Fletcher G, Kraus WE. Relationship of age and exercise performance in patients with heart failure: the HF-ACTION study. Am Heart J. 2009;158(4 Suppl 1):S6-S15.

Gardin JM, Leifer ES, Fleg JL, Whellan D, Kokkinos P, LeBlanc M-H, Wolfel E, Kitzman DW. Relationship of Doppler-echocardiographic left ventricular diastolic function to exercise performance in systolic heart failure: the HF-ACTION study. Am Heart J. 2009;158(4 Suppl 1):S45-S52.

Atchley AE, Kitzman DW, Whellan DJ, Iskandrian AE, Ellis SJ, Shaw LK, Pagnanelli RA, Kao A, Abdul-Nour K, Ewald G, et al. Relationship of baseline gated rest SPECT myocardial perfusion imaging to death and hospitalization in heart failure patients: results from the Nuclear Substudy of the HF-ACTION Trial [abstract]. J Card Fail. 2009;15(9):814.

Myers J, Arena R, Oliveira RB, Bensimhon D, Hsu L, Chase P, Guazzi M, Brubaker P, Moore B, Kitzman D, et al. The lowest VE/VCO2 ratio during exercise as a predictor of outcomes in patients with heart failure. J Card Fail. 2009;15(9):756-762.

Puntawangkoon C, Kitzman DW, Kritchevsky SB, Hamilton CA, Nicklas B, Leng X, Brubaker PH, Hundley WG. Reduced peripheral arterial blood flow with preserved cardiac output during submaximal bicycle exercise in elderly heart failure. J Cardiovasc Magn Reson. 2009;11(1):article 48.

Fleg JL, Leifer E, Kitzman DW, Whellan DJ, Kokkinos P, Wolfel G, Gardin JM. Clinical and Doppler echocardiographic correlates of VE/VCO2 slope in systolic heart failure: the HF-ACTION Trial [abstract]. Circulation. 2009;120(18 Suppl 2):S365.

Forman DE, Clare R, Kitzman DW, Ellis SJ, Chiara T, Fletcher G, Fleg JL, Kraus WE. Impact of age on aerobic capacity in patients with systolic heart failure: the HF-ACTION Study [abstract]. Circulation. 2009;120(18 Suppl 2):S550.

Kitzman DW, Haas MM, Carson PE, Hetzel S, Komajda M, Zile M, Johnson RH, Mckelvie R, Mcmurray JJ, Demets D, et al. Obesity and its relationship to adverse cardiovascular outcomes in older patients with heart failure and preserved ejection fraction in the I-PRESERVE Trial [abstract]. Circulation. 2009;120(18 Suppl 2):S757-S758.

Groban L, Yamaleyeva LM, Westwood BM, Houle TT, Lin M, Kitzman DW, Chappell MC. Progressive diastolic dysfunction in the female mRen(2).Lewis rat: influence of salt and ovarian hormones. J Gerontol A Biol Sci Med Sci. 2008;63(1):3-11.

Kitzman DW, Groban L. Exercise intolerance. Heart Fail Clin. 2008;4(1):99-115.


Groban L, Jobe H, Lin M, Houle T, Kitzman DA, Sonntag W. Effects of short-term treadmill exercise training or growth hormone supplementation on diastolic function and exercise tolerance in old rats. J Gerontol A Biol Sci Med Sci. 2008;63(9):911-920.

Nicklas BJ, Leng I, Delbono O, Kitzman DW, Marsh AP, Hundley WG, Lyles MF, O'Rourke KS, Annex BH, Kraus WE. Relationship of physical function to vastus lateralis capillary density and metabolic enzyme activity in elderly men and women. Aging Clin Exp Res. 2008;20(4):302-309.

Bensimhon DR, Leifer ES, Ellis SJ, Fleg JL, Keteyian SJ, Pina IL, Kitzman DW, McKelvie RS, Kraus WE, Forman DE, et al. Reproducibility of peak oxygen uptake and other cardiopulmonary exercise testing parameters in patients with heart failure (from the Heart Failure and A Controlled Trial Investigating Outcomes of exercise traiNing). Am J Cardiol. 2008;102(6):712-717.

Arena R, Myers J, Abella J, Pinkstaff S, Brubaker P, Moore B, Kitzman D, Peberdy MA, Bensimhon D, Chase P, et al. The partial pressure of resting end-tidal carbon dioxide predicts major cardiac events in patients with systolic heart failure. Am Heart J. 2008;156(5):982-988.

Mulvagh SL, Rakowski H, Vannan MA, Abdelmoneim SS, Becher H, Bierig SM, Burns PN, Castello R, Coon PD, Kitzman DW, et al. American Society of Echocardiography Consensus Statement on the clinical applications of ultrasonic contrast agents in echocardiography. J Am Soc Echocardiogr. 2008;21(11):1179-1201.

Arena R, Brubaker P, Moore B, Kitzman D. The oxygen uptake efficiency slope is reduced in older patients with heart failure and a normal ejection fraction [abstract]. Circulation. 2008;118(18 Suppl 2):S1023.

Barasch E, Gottdiener JS, Han J, Aurigemma GP, Kitzman DW, Tracy R. The relation between age and serum markers of collagen turnover in healthy elderly individuals; the Cardiovascular Health Study [abstract]. Circulation. 2008;118(18 Suppl 2):S1084.

Borges-Neto S, Iskandrian AE, Whellan DJ, O'Connor CM, Ellis SJ, Pagnanelli R, Settles S, Kao A, Abdul-Nour K, Kitzman D, et al. Effect of exercise training on myocardial perfusion, function and dyssynchrony, in heart failure patients: a sub-study of the HF-ACTION Trial [abstract]. Circulation. 2008;118(18 Suppl 2):S1028.

Nicklas BJ, Brinkley T, Leng X, Miller M, Kitzrnan D [sic] [Kitzman D], Berry M, Marsh A, Pahor M, Kritchevsky S. Chronic inflammation is associated with low physical function in older adults across multiple comorbidities [abstract]. Gerontologist. 2008;48(Special Issue 3):491-492.

Kitzman DW, John JM. Exercise intolerance in diastolic heart failure In: Klein AL, Garcia MJ, eds. Diastology: clinical approach to diastolic heart failure. Philadelphia: Saunders/Elsevier;2008: 203-213.

Kitzman DW, Fleg JL. Heart failure In: Aronow WS, Fleg JL, Rich MW, eds. Cardiovascular disease in the elderly. 4th ed. New York: Informa Healthcare USA;2008: 541-576.

Kitzman DW, Daniel KR. Diastolic heart failure in the elderly. Clin Geriatr Med. 2007;23(1):83-106.

Hundley WG, Bayram E, Hamilton CA, Hamilton EA, Morgan TM, Darty SN, Stewart KP, Link KM, Herrington DM, Kitzman DW. Leg flow-mediated arterial dilation in elderly patients with heart failure and normal left ventricular ejection fraction. Am J Physiol Heart Circ Physiol. 2007;292(3):H1427-1434.

Liao L, Anstrom KJ, Gottdiener JS, Pappas PA, Whellan DJ, Kitzman DW, Aurigemma GP, Mark DB, Schulman KA, Jollis JG. Long-term costs and resource use in elderly participants with congestive heart failure in the Cardiovascular Health Study. Am Heart J. 2007;153(2):245-252.

Whellan DJ, O'Connor CM, Lee KL, Keteyian SJ, Cooper LS, Ellis SJ, Leifer ES, Kraus WE, Kitzman DW, Blumenthal JA, et al. Heart failure and a controlled trial investigating outcomes of exercise TraiNing (HF-ACTION): design and rationale. Am Heart J. 2007;153(2):201-211.

Ahmed A, Zile MR, Rich MW, Fleg JL, Adams KF Jr, Love TE, Young JB, Aronow WS, Kitzman DW, Gheorghiade M, et al. Hospitalizations due to unstable angina pectoris in diastolic and systolic heart failure. Am J Cardiol. 2007;99(4):460-464.

Bella JN, Tang W, Kraja A, Rao DC, Hunt SC, Miller MB, Palmieri V, Roman MJ, Kitzman DW, Oberman A, et al. Genome-wide linkage mapping for valve calcification susceptibility loci in hypertensive sibships: the Hypertension Genetic Epidemiology Network Study. Hypertension. 2007;49(3):453-460.

Kritchevsky SB, Leng I, Miller ME, Ding JZ, Kitzman D. DXA derived body composition measures are consistently associated with physical performance across 4 older populations [abstract]. FASEB J. 2007;21(6):A1068.

Brubaker PH, Kitzman DW. Prevalence and management of chronotropic incompetence in heart failure. Curr Cardiol Rep. 2007;9(3):229-235.


Sherva R, Miller MB, Lynch AI, Devereux RB, Rao DC, Oberman A, Hopkins PN, Kitzman DW, Atwood LD, Arnett DK. A whole genome scan for pulse pressure/stroke volume ratio in African Americans: the HyperGEN study. Am J Hypertens. 2007;20(4):398-402.

de Simone G, Tang W, Devereux RB, Hunt SC, Kitzman DW, Rao DC, Arnett DK. Assessment of the interaction of heritability of volume load and left ventricular mass: the HyperGEN offspring study. J Hypertens. 2007;25(7):1397-1402.

Kitzman DW, Daniel KR. Diastolic heart failure in the elderly. Heart Fail Clin. 2007;3(4):437-453.

Wenger NS, Solomon DH, Amin A, Besdine RK, Blazer DG, Cohen H, Fulmer T, Ganz PA, Grunwald M, Kitzman DW, et al. Application of assessing care of vulnerable elders-3 quality indicators to patients with advanced dementia and poor prognosis. J Am Geriatr Soc. 2007;55(Suppl 2):S457-S463.

Maldonado-Martin S, Brubaker PH, Kaminsky LA, Moore JB, Stewart KP, Kitzman DW. The relationship of 6-min walk to VO2peak and VT in older heart failure patients. Med Sci Sports Exerc. 2006;38(6):1047-1053.

Little WC, Zile MR, Klein A, Appleton CP, Kitzman DW, Wesley-Farrington DJ. Effect of losartan and hydrochlorothiazide on exercise tolerance in exertional hypertension and left ventricular diastolic dysfunction. Am J Cardiol. 2006;98(3):383-385.

Bryson CL, Mukamal KJ, Mittleman MA, Fried LP, Hirsch CH, Kitzman DW, Siscovick DS. The association of alcohol consumption and incident heart failure: the Cardiovascular Health Study. J Am Coll Cardiol. 2006;48(2):305-311.

Ahmed A, Rich MW, Fleg JL, Zile MR, Young JB, Kitzman DW, Love TE, Aronow WS, Adams KF Jr, Gheorghiade M. Effects of digoxin on morbidity and mortality in diastolic heart failure: the ancillary Digitalis Investigation Group trial. Circulation. 2006;114(5):397-403.

Ahmed A, Perry GJ, Fleg JL, Love TE, Goff DC Jr, Kitzman DW. Outcomes in ambulatory chronic systolic and diastolic heart failure: a propensity score analysis. Am Heart J. 2006;152(5):956-966.

Bella JN, Tang W, Kraja A, Hunt SC, Miller M, Palmieri V, Roman MJ, Kitzman DW, Oberman A, Devereux RB, et al. Genetic linkage of aortic valve sclerosis and mitral annular calcification: the HyperGEN study [abstract]. Circulation. 2006;114(18 Suppl):845-846.

Gottdiener JS, Massie BM, Carson PE, Bhaumik A, Ptzszynska A, Komajda M, McKelvie R, Kitzman D, McMurray J, Zile M. Cardiac structural changes and diastolic function in heart failure with preserved ejection fraction--importance of left atrial volume: the iPRESERVE study [abstract]. Circulation. 2006;114(18 Suppl):816.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Cardiology

Clinical Specialties

Heart Failure, Cardiac Imaging, Stress Testing, Diastolic Dysfunction, Cardiology (clinical), Echocardiography, Geriatric Medicine and Assessment

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