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Dalane W. Kitzman, M.D.Wake Forest School of Medicine

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Dalane W. Kitzman, M.D.

Professor,



Clinical Interests

Cardiac Imaging, Cardiology (clinical), Diastolic Dysfunction, Echocardiography, Geriatric Medicine and Assessment, Heart Failure, Stress Testing

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Education & Training

  • B.A., Johns Hopkins University, 1981
  • M.D., Johns Hopkins University School of Medicine, 1984
  • Internship, Internal Medicine, Mayo Graduate School, 1985
  • Residency, Internal Medicine, Mayo Graduate School, 1987
  • Fellowship, Duke University Hospital, 1990

Board Certifications

  • American Board of Internal Medicine, Internal Medicine
  • American Board of Internal Medicine, Internal Medicine, Cardiovascular Disease

Memberships

  • Albemarle County Medical Socie
  • Am Assn Of Clinical Anatomists
  • Am Coll Of Physicians
  • Am Medical Assn
  • Am Soc Of Echocardiography
  • Am Soc Of Internal Medicine
  • American College of Cardiology
  • Forsyth Prepared Childbirth As

NPI Number

  • 1396720678
Dalane W. Kitzman, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

Dalane W. Kitzman, M.D.

Professor, Cardiology
Sticht Center on Aging
Gerontology and Geriatric Medicine
Translational Science Institute

Research Interests

aging, cardiac function, fitness/physical, hypertension, obesity, rehabilitation, neurosciences/behavior, epidemiology

Contact Information

Request An Appointment

Academic: 336-716-3274 | Department: 336-716-3274

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Recent Publications

Schievink B, de Zeeuw D, Smink PA, Andress D, Brennan JJ, Coll B, Correa-Rotter R, Hou FF, Kohan D, Kitzman DW, Makino H, Parving HH, Perkovic V, Remuzzi G, Tobe S, Toto R, Hoekman J, Lambers Heerspink HJ. Prediction of the effect of atrasentan on renal and heart failure outcomes based on short-term changes in multiple risk markers. Eur J Prev Cardiol. 2016;23(7):758-768.

Shao Q, Cheng HJ, Callahan MF, Kitzman DW, Li WM, Cheng CP. Overexpression myocardial inducible nitric oxide synthase exacerbates cardiac dysfunction and beta-adrenergic desensitization in experimental hypothyroidism. Int J Cardiol. 2016;204():229-241.

Kitzman DW, Haykowsky MJ. Vascular dysfunction in heart failure with preserved ejection fraction [editorial]. J Card Fail. 2016;22(1):12-16.

Kitzman DW, Brubaker P, Morgan T, Haykowsky M, Hundley G [sic] [Hundley WG], Kraus WE, Eggebeen J, Nicklas BJ. Effect of caloric restriction or aerobic exercise training on peak oxygen consumption and quality of life in obese older patients with heart failure with preserved ejection fraction: a randomized clinical trial. JAMA. 2016;315(1):36-46.

Huggins GS, Berkowitz RI, Blackburn GL, Bray GA, Cheskin L, Clark JM, Coday M, Espeland MA, Evans M, Foreyt JP, Glasser S, Greenway FL, Gregg EW, Hanson RL, Hazuda HP, Hill JO, Horton ES, Jakicic JM, Jeffery RW, Johnson KC, Kahn SE, Kitzman DW,. Prospective association of GLUL rs10911021 with cardiovascular morbidity and mortality among individuals with type 2 diabetes: the Look AHEAD Study. Diabetes. 2016;65(1):297-302.

Chang TI, Evans G, Cheung AK, Cushman WC, Diamond MJ, Dwyer JP, Huan Y, Kitzman D, Kostis JB, Oparil S, Rastogi A, Roumie CL, Sahay R, Stafford RS, Taylor AA, Wright JT Jr, Chertow GM. Patterns and correlates of baseline thiazide-type diuretic prescription in the systolic blood pressure intervention trial. Hypertension. 2016;67(3):550-555.

Eggebeen J, Kim-Shapiro DB, Haykowsky M, Morgan TM, Basu S, Brubaker P, Rejeski J, Kitzman DW. One week of daily dosing with beetroot juice improves submaximal endurance and blood pressure in older patients with heart failure and preserved ejection fraction. JACC Heart Fail. 2016;():.

Goncalves A, Hung CL, Claggett B, Nochioka K, Cheng S, Kitzman DW, Shah AM, Solomon SD. Left atrial structure and function across the spectrum of cardiovascular risk in the elderly: the Atherosclerosis Risk in Communities study. Circ Cardiovasc Imaging. 2016;9(2):e004010.

Kitzman DW. Precious memory. J Am Geriatr Soc. 2016;64(3):640.

Mehta H, Armstrong A, Swett K, Shah SJ, Allison MA, Hurwitz B, Bangdiwala S, Dadhania R, Kitzman DW, Arguelles W, Lima J, Youngblood M, Schneiderman N, Daviglus ML, Spevack D, Talavera GA, Raisinghani A, Kaplan R, Rodriguez CJ. Burden of systolic and diastolic left ventricular dysfunction among Hispanics in the United States: insights from the Echocardiographic Study of Latinos. Circ Heart Fail. 2016;9(4):e002733.

Molina AJ, Bharadwaj MS, Van Horn C, Nicklas BJ, Lyles MF, Eggebeen J, Haykowsky MJ, Brubaker PH, Kitzman DW. Skeletal muscle mitochondrial content, oxidative capacity, and Mfn2 expression are reduced in older patients with heart failure and preserved ejection fraction and are related to exercise intolerance. JACC Heart Fail. 2016;():.

Reeves GR, Whellan DJ, Patel MJ, O'Connor CM, Duncan P, Eggebeen JD, Morgan TM, Hewston LA, Pastva AM, Kitzman DW. Comparison of frequency of frailty and severely impaired physical function in patients greater than or equal to 60 years hospitalized with acute decompensated heart failure versus chronic stable heart failure with reduced and preserved. Am J Cardiol. 2016;117(12):1953-1958.

Williamson JD, Supiano MA, Applegate WB, Berlowitz DR, Campbell RC, Chertow GM, Fine LJ, Haley WE, Hawfield AT, Ix JH, Kitzman DW, Kostis JB, Krousel-Wood MA, Launer LJ, Oparil S, Rodriguez CJ, Roumie CL, Shorr RI, Sink KM, Wadley VG,. Intensive vs standard blood pressure control and cardiovascular disease outcomes in adults aged greater than or equal to 75 years: a randomized clinical trial. JAMA. 2016;():.

Zhang ZM, Rautaharju PM, Prineas RJ, Rodriguez CJ, Loehr L, Rosamond WD, Kitzman D, Couper D, Soliman EZ. Race and sex differences in the incidence and prognostic significance of silent myocardial infarction in the Atherosclerosis Risk in Communities (ARIC) study. Circulation. 2016;133(22):2141-2148.

Andersen MM, Kritchevsky SB, Morgan TM, Hire DG, Vasu S, Brinkley TE, Kitzman DW, Hamilton CA, Soots S, Hundley WG. Increased cardiovascular stiffness and impaired age-related functional status. J Gerontol A Biol Sci Med Sci. 2015;70(5):545-553.

Pandey A, Parashar A, Kumbhani DJ, Agarwal S, Garg J, Kitzman D, Levine BD, Drazner M, Berry JD. Exercise training in patients with heart failure and preserved ejection fraction: meta-analysis of randomized control trials. Circ Heart Fail. 2015;8(1):33-40.

Zeitler EP, Piccini JP, Hellkamp AS, Whellan DJ, Jackson KP, Ellis SJ, Kraus WE, Keteyian SJ, Kitzman DW, Ewald GA, Fleg JL, Pina IL, O'Connor CM. Exercise training and pacing status in patients with heart failure: results from HF-ACTION. J Card Fail. 2015;21(1):60-67.

Kitzman DW, Upadhya B, Vasu S. What the dead can teach the living: systemic nature of heart failure with preserved ejection fraction [editorial]. Circulation. 2015;131(6):522-524.

Quarta CC, Buxbaum JN, Shah AM, Falk RH, Claggett B, Kitzman DW, Mosley TH, Butler KR, Boerwinkle E, Solomon SD. The amyloidogenic V122I transthyretin variant in elderly black Americans. N Engl J Med. 2015;372(1):21-29.

Fleg JL, Cooper LS, Borlaug BA, Haykowsky MJ, Kraus WE, Levine BD, Pfeffer MA, Pina IL, Poole DC, Reeves GR, Whellan DJ, Kitzman DW. Exercise training as therapy for heart failure: current status and future directions. Circ Heart Fail. 2015;8(1):209-220.

Vasu S, Morgan TM, Kitzman DW, Bertoni A, Stacey RB, Hamilton C, Chiles C, Thohan V, Hundley WG. Abnormal stress-related measures of arterial stiffness in middle-aged and elderly men and women with impaired fasting glucose at risk for a first episode of symptomatic heart failure. J Am Heart Assoc. 2015;4(1):e000991.

Kritchevsky SB, Beavers KM, Miller ME, Shea MK, Houston DK, Kitzman DW, Nicklas BJ. Intentional weight loss and all-cause mortality: a meta-analysis of randomized clinical trials. PLoS One. 2015;10(3):e0121993.

Upadhya B, Haykowsky MJ, Eggebeen J, Kitzman DW. Sarcopenic obesity and the pathogenesis of exercise intolerance in heart failure with preserved ejection fraction. Curr Heart Fail Rep. 2015;12(3):205-214.

Upadhya B, Taffet GE, Cheng CP, Kitzman DW. Heart failure with preserved ejection fraction in the elderly: scope of the problem. J Mol Cell Cardiol. 2015;83():73-87.

Whellan DJ, Kraus WE, Kitzman DW, Rooney B, Keteyian SJ, Pina IL, Ellis SJ, Ghali JK, Lee KL, Cooper LS, O'Connor CM. Authorship in a multicenter clinical trial: the Heart Failure-a controlled trial investigating outcomes of exercise training (HF-ACTION) Authorship and Publication (HAP) scoring system results. Am Heart J. 2015;169(4):457-463.e6.

Haykowsky MJ, Tomczak CR, Scott JM, Patterson DI, Kitzman DW. Determinants of exercise intolerance in patients with heart failure and reduced or preserved ejection fraction. J Appl Physiol (1985). 2015;119(6):739-744.

Houston DK, Miller ME, Kitzman DW, Rejeski WJ, Messier SP, Lyles MF, Kritchevsky S, Nicklas BJ. The long-term effects of intentional weight loss on body composition and physical function in older adults: a pilot study [abstract]. J Am Geriatr Soc. 2015;63(Suppl 1):S14-S15.

Kitzman DW, Upadhya B, Reeves G. Hospitalizations and prognosis in elderly patients with heart failure and preserved ejection fraction: time to treat the whole patient [editorial comment]. JACC Heart Fail. 2015;3(6):442-444.

Upadhya B, Haykowsky MJ, Eggebeen J, Kitzman DW. Exercise intolerance in heart failure with preserved ejection fraction: more than a heart problem. J Geriatr Cardiol. 2015;12(3):294-304.

Ahmad T, O'Brien EC, Schulte PJ, Stevens SR, Fiuzat M, Kitzman DW, Adams KF, Kraus WE, Pina IL, Donahue MP, Zannad F, Whellan DJ, O'Connor C, Felker GM. Evaluation of the incremental prognostic utility of increasingly complex testing in chronic heart failure. Circ Heart Fail. 2015;8(4):709-716.

Goncalves A, Jhund PS, Claggett B, Shah AM, Konety S, Butler K, Kitzman DW, Rosamond W, Fuchs FD, Solomon SD. Relationship between alcohol consumption and cardiac structure and function in the elderly: the Atherosclerosis Risk in Communities study. Circ Cardiovasc Imaging. 2015;8(6):e002846.

Rodriguez CJ, Dharod A, Allison MA, Shah SJ, Hurwitz B, Bangdiwala SI, Gonzalez F, Kitzman D, Gillam L, Spevack D, Dadhania R, Langdon S, Kaplan R. Rationale and design of the echocardiographic study of Hispanics/Latinos (ECHO-SOL). Ethn Dis. 2015;25(2):180-186.

Murad K, Goff DC Jr, Morgan TM, Burke GL, Bartz TM, Kizer JR, Chaudhry SI, Gottdiener JS, Kitzman DW. Burden of comorbidities and functional and cognitive impairments in elderly patients at the initial diagnosis of heart failure and their impact on total mortality: the Cardiovascular Health Study. JACC Heart Fail. 2015;3(7):542-550.

Kitzman DW. Doris's list [editorial]. J Am Geriatr Soc. 2015;63(7):1467-1468.

Ohara T, Iwano H, Thohan V, Kitzman DW, Upadhya B, Pu M, Little WC. Role of diastolic function in preserved exercise capacity in patients with reduced ejection fractions. J Am Soc Echocardiogr. 2015;28(10):1184-1193.

Kitzman DW. Conventional wisdom in heart failure treatment challenged again: does heart rate lowering worsen exercise intolerance in heart failure with preserved ejection fraction? [editorial]. Circulation. 2015;132(18):1687-1689.

Goncalves A, Chung-Lieh HUNG, Claggett B, Nochioka K, Shah AM, Cheng S, Kitzman DW, Solomon SD. Left atrial function across the spectrum of cardiovascular disease in the elderly- the ARIC study [abstract]. Eur Heart J. 2015;36(Suppl 1):541.

Banks AZ, Mentz RJ, Stebbins A, PhD CR, Schulte PJ, Fleg JL, Cooper LS, Leifer ES, Badenhop DT, Keteyian SJ, Pina IL, Kitzman DW, Fiuzat M, Whellan DJ, Kraus WE, O'Connor CM. Response to exercise training and outcomes in patients with heart failure and diabetes mellitus: insights from HF-ACTION. J Card Fail. 2015;():.

Cheng C-P, Cheng H-J, Zhou P, Li T, Zhang X, Kitzman D, Callahan M. Oxidative stress from altered cardiac beta3-adrenergic receptor-activated inducible nitric oxide synthase/NO pathways promotes cardiac aging [abstract]. Circulation. 2015;132(Suppl 3):A15427.

Cheng H-J, Zhou P, Li T, Zhang X, Masutani S, Kitzman D, Little W, Cheng C-P. Molecular basis of the protective effect of beta3-adrenergic receptor deficiency on myocardial aging: reversal of aging-induced contrast changes of cardiac SERCA 2a and inducible nitric oxide synthase [abstract]. Circulation. 2015;132(Suppl 3):A14261.

Groban L, Kitzman DW, Register TC, Shively CA. Effect of depression and sertraline treatment on cardiac function in female nonhuman primates. Psychosom Med. 2014;76(2):137-146.

Ahmad T, Fiuzat M, Mark DB, Neely B, Neely M, Kraus WE, Kitzman DW, Whellan DJ, Donahue M, Zannad F, Pina IL, Adams K, O'Connor CM, Felker GM. The effects of exercise on cardiovascular biomarkers in patients with chronic heart failure. Am Heart J. 2014;167(2):193-202.

Shah AM, Cheng S, Skali H, Wu J, Mangion JR, Kitzman D, Matsushita K, Konety S, Butler KR, Fox ER, Cook N, Ni H, Coresh J, Mosley TH, Heiss G, Folsom AR, Solomon SD. Rationale and design of a multicenter echocardiographic study to assess the relationship between cardiac structure and function and heart failure risk in a biracial cohort of community-dwelling. Circ Cardiovasc Imaging. 2014;7(1):173-181.

Haykowsky MJ, Kouba EJ, Brubaker PH, Nicklas BJ, Eggebeen J, Kitzman DW. Skeletal muscle composition and its relation to exercise intolerance in older patients with heart failure and preserved ejection fraction. Am J Cardiol. 2014;113(7):1211-1216.

Kitzman DW, Upadhya B. Heart failure with preserved ejection fraction: a heterogenous disorder with multifactorial pathophysiology [editorial comment]. J Am Coll Cardiol. 2014;63(5):457-459.

Patel K, Fonarow GC, Ekundayo OJ, Aban IB, Kilgore ML, Love TE, Kitzman DW, Gheorghiade M, Allman RM, Ahmed A. Beta-blockers in older patients with heart failure and preserved ejection fraction: class, dosage, and outcomes. Int J Cardiol. 2014;173(3):393-401.

Jordan JH, Haag JC, Morgan TM, Vasu S, Stacey B, Hamilton C, Robinson K, Kitzman D, Thohan V, Hundley WG. Small, short-duration, dobutamine-induced perfusion defects are not associated with adverse prognosis in intermediate-risk individuals receiving cardiovascular magnetic resonance stress imaging. J Comput Assist Tomogr. 2014;38(3):427-433.

Kitzman DW, Nicklas B, Kraus WE, Lyles MF, Eggebeen J, Morgan TM, Haykowsky M. Skeletal muscle abnormalities and exercise intolerance in older patients with heart failure and preserved ejection fraction. Am J Physiol Heart Circ Physiol. 2014;306(9):H1364-1370.

Brinkley TE, Leng X, Chughtai HL, Nicklas BJ, Kritchevsky SB, Ding J, Kitzman DW, Hundley WG. Periaortic fat and cardiovascular risk: a comparison of high-risk older adults and age-matched healthy controls. Int J Obes (Lond). 2014;38(11):1397-1402.

Ahmad T, Fiuzat M, Neely B, Neely ML, Pencina MJ, Kraus WE, Zannad F, Whellan DJ, Donahue MP, Pina IL, Adams KF, Kitzman DW, O'Connor CM, Felker GM. Biomarkers of myocardial stress and fibrosis as predictors of mode of death in patients with chronic heart failure. JACC Heart Fail. 2014;2(3):260-268.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Cardiology

Clinical Interests

Cardiac Imaging, Cardiology (clinical), Diastolic Dysfunction, Echocardiography, Geriatric Medicine and Assessment, Heart Failure, Stress Testing

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