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Dalane W. Kitzman, M.D.Wake Forest School of Medicine

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Dalane W. Kitzman, M.D.

Professor,

Office of Research

Clinical Interests

Heart Failure, Cardiac Imaging, Stress Testing, Diastolic Dysfunction, Cardiology (clinical), Echocardiography, Geriatric Medicine and Assessment

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Education & Training

  • B.A., Johns Hopkins University, 1981
  • M.D., Johns Hopkins University School of Medicine, 1984
  • Internship, Internal Medicine, Mayo Graduate School, 1985
  • Residency, Internal Medicine, Mayo Graduate School, 1987
  • Fellowship, Duke University Hospital, 1990

Board Certifications

  • American Board of Internal Medicine, Cardiovascular Disease

Memberships

  • Am Assn Of Clinical Anatomists
  • American College of Cardiology
  • Am Coll Of Physicians
  • Am Medical Assn
  • Am Soc Of Echocardiography
  • Am Soc Of Internal Medicine
  • Albemarle County Medical Socie
  • Forsyth Prepared Childbirth As

NPI Number

  • 1396720678
Dalane W. Kitzman, M.D.

Doctor Rating

No Rating Available
Why No Ratings?

Dalane W. Kitzman, M.D.

Professor, Cardiology
Gerontology and Geriatric Medicine
Office of Research

Research Interests

Heart Failure; Stroke Volume; Exercise Tolerance; Oxygen Consumption; Ventricular Function, Left
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Contact Information

Request An Appointment

Academic: 336-716-3274 | Department: 336-716-3274

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Recent Publications

Association between 6-minute walk test distance and objective variables of functional capacity after exercise training in elderly heart failure patients with preserved ejection fraction: a randomized exercise trial. Maldonado-Martin S, Brubaker PH, Eggebeen J, Stewart KP, Kitzman DW.. Arch Phys Med Rehabil. 2017;98(3):600-603.

Cardiovascular dysfunction and frailty among older adults in the community: the ARIC Study. Nadruz W Jr, Kitzman D, Windham BG, Kucharska-Newton A, Butler K, Palta P, Griswold ME, Wagenknecht LE, Heiss G, Solomon SD, Skali H, Shah AM.. J Gerontol A Biol Sci Med Sci. 2017;72(7):958-964.

New concepts in an old disease: exercise intolerance in moderate mitral stenosis [editorial comment]. Kitzman DW, Upadhya B, Zhao D.. JACC Cardiovasc Imaging. 2017;10(6):634-636.

Heart failure stages among older adults in the community: the Atherosclerosis Risk in Communities study. Shah AM, Claggett B, Loehr LR, Chang PP, Matsushita K, Kitzman D, Konety SH, Kucharska-Newton A, Sueta CA, Mosley TH Jr, Wright JD, Coresh J, Heiss G, Folsom AR, Solomon SD.. Circulation. 2017;135(3):224-240.

Contemporary assessment of left ventricular diastolic function in older adults: the Atherosclerosis Risk in Communities study. Shah AM, Claggett B, Kitzman D, Biering-Sorensen T, Jensen JS, Cheng S, Matsushita K, Konety SH, Folsom AR, Mosley TH Jr, Wright J, Heiss G, Solomon SD.. Circulation. 2017;135(5):426-439.

Race-related differences in left ventricular structural and functional remodeling in response to increased afterload: the ARIC study. Fernandes-Silva MM, Shah AM, Hegde S, Goncalves A, Claggett B, Cheng S, Nadruz W, Kitzman DW, Konety SH, Matsushita K, Mosley T, Lam CS, Borlaug BA, Solomon SD.. JACC Heart Fail. 2017;5(3):157-165.

Understanding the journey. Kitzman DW.. J Am Geriatr Soc. 2017;65(2):443.

Age- and sex-related influences on left ventricular mechanics in elderly individuals free of prevalent heart failure: the ARIC study (Atherosclerosis Risk in Communities). Hung CL, Goncalves A, Shah AM, Cheng S, Kitzman D, Solomon SD.. Circ Cardiovasc Imaging. 2017;10(1):e004510.

Cellular basis of angiotensin-(1-7)-induced augmentation of left ventricular functional performance in heart failure. Zhang X, Cheng HJ, Zhou P, Kitzman DW, Ferrario CM, Li WM, Cheng CP.. Int J Cardiol. 2017;236():405-412.

Effect of intensive blood pressure control on gait speed and mobility limitation in adults 75 years or older: a randomized clinical trial. Odden MC, Peralta CA, Berlowitz DR, Johnson KC, Whittle J, Kitzman DW, Beddhu S, Nord JW, Papademetriou V, Williamson JD, Pajewski NM.. JAMA Intern Med. 2017;177(4):500-507.

Young dads and old men. Kitzman DW.. J Am Geriatr Soc. 2017;65(6):1362-1363.

Unraveling the relationship between aging and heart failure with preserved ejection fraction: the importance of exercise and normative reference standards [editorial comment]. Kitzman DW, O'Neill TJ IV, Brubaker PH.. JACC Heart Fail. 2017;5(5):356-358.

Rehabilitation therapy in older acute heart failure patients (REHAB-HF) trial: design and rationale. Reeves GR, Whellan DJ, Duncan P, O'Connor CM, Pastva AM, Eggebeen JD, Hewston LA, Morgan TM, Reed SD, Rejeski WJ, Mentz RJ, Rosenberg PB, Kitzman DW.. Am Heart J. 2017;185():130-139.

A novel rehabilitation intervention for older patients with acute decompensated heart failure: the REHAB-HF pilot study. Reeves GR, Whellan DJ, O'Connor CM, Duncan P, Eggebeen JD, Morgan TM, Hewston LA, Pastva A, Patel MJ, Kitzman DW.. JACC Heart Fail. 2017;5(5):359-366.

Management of heart failure with preserved ejection fraction: current challenges and future directions. Upadhya B, Kitzman DW.. Am J Cardiovasc Drugs. 2017;17(4):283-298.

Reassessing phase II heart failure clinical trials: consensus recommendations. Butler J, Hamo CE, Udelson JE, O'Connor C, Sabbah HN, Metra M, Shah SJ, Kitzman DW, Teerlink JR, Bernstein HS, Brooks G, Depre C, DeSouza MM, Dinh W, Donovan M, Frische-Danielson R, Frost RJ, Garza D, Gohring UM, Hellawell J, Hsia J,.. Circ Heart Fail. 2017;10(4):e003800.

Response to endurance exercise training in older adults with heart failure with preserved or reduced ejection fraction. Pandey A, Kitzman DW, Brubaker P, Haykowsky MJ, Morgan T, Becton JT, Berry JD.. J Am Geriatr Soc. 2017;65(8):1698-1704.

Racial differences in circulating levels of the soluble receptor for advanced glycation endproducts in middle-aged and older adults. Brinkley TE, Leng X, Nicklas BJ, Kritchevsky SB, Ding J, Kitzman DW, Hundley WG.. Metabolism. 2017;70():98-106.

Exercise training in patients with chronic heart failure and atrial fibrillation. Luo N, Merrill P, Parikh KS, Whellan DJ, Pina IL, Fiuzat M, Kraus WE, Kitzman DW, Keteyian SJ, O'Connor CM, Mentz RJ.. J Am Coll Cardiol. 2017;69(13):1683-1691.

Effect of intensive blood pressure treatment on heart failure events in the Systolic Blood Pressure Reduction Intervention Trial. Upadhya B, Rocco M, Lewis CE, Oparil S, Lovato LC, Cushman WC, Bates JT, Bello NA, Aurigemma G, Fine LJ, Johnson KC, Rodriguez CJ, Raj DS, Rastogi A, Tamariz L, Wiggers A, Kitzman DW.. Circ Heart Fail. 2017;10(4):e003613.

Effects of aging on cardiovascular structure and function. Kitzman DW, Upadhya B, Haykowsky M, Taffet GE. In: Halter JB, Ouslander JG, Studenski S, High KP, Asthana S, Supiano MA, Ritchie C, Hazzard WR, Woolard NF, eds. Hazzard's geriatric medicine and gerontology. 7th ed. New York: McGraw-Hill Education Medical;2017: .

Long-term sertraline treatment and depression effects on carotid artery atherosclerosis in premenopausal female primates. Silverstein-Metzler MG, Justice JN, Appt SE, Groban L, Kitzman DW, Carr JJ, Register TC, Shively CA.. Menopause. 2017;24(10):1175-1184.

Effect of spironolactone on exercise tolerance and arterial function in older adults with heart failure with preserved ejection fraction. Upadhya B, Hundley WG, Brubaker PH, Morgan TM, Stewart KP, Kitzman DW.. J Am Geriatr Soc. 2017;():.

Research priorities to advance the health and health care of older adults with multiple chronic conditions. Tisminetzky M, Bayliss EA, Magaziner JS, Allore HG, Anzuoni K, Boyd CM, Gill TM, Go AS, Greenspan SL, Hanson LR, Hornbrook MC, Kitzman DW, Larson EB, Naylor MD, Shirley BE, Tai-Seale M, Teri L, Tinetti ME, Whitson HE, Gurwitz JH.. J Am Geriatr Soc. 2017;65(7):1549-1553.

Physical function and exercise training in older patients with heart failure. Coats AJS, Forman DE, Haykowsky M, Kitzman DW, McNeil A, Campbell TS, Arena R.. Nat Rev Cardiol. 2017;14(9):550-559.

Heart failure with preserved ejection fraction in older adults. Upadhya B, Kitzman DW.. Heart Fail Clin. 2017;13(3):485-502.

Electrocardiographic predictors of heart failure with reduced versus preserved ejection fraction: the Multi-Ethnic Study of Atherosclerosis. O'Neal WT, Mazur M, Bertoni AG, Bluemke DA, Al-Mallah MH, Lima JAC, Kitzman D, Soliman EZ.. J Am Heart Assoc. 2017;6(6):e006023.

Prioritizing functional capacity as a principal end point for therapies oriented to older adults with cardiovascular disease: a scientific statement for healthcare professionals from the American Heart Association. Forman DE, Arena R, Boxer R, Dolansky MA, Eng JJ, Fleg JL, Haykowsky M, Jahangir A, Kaminsky LA, Kitzman DW, Lewis EF, Myers J, Reeves GR, Shen WK.. Circulation. 2017;135(16):e894-e918.

Effects of supervised exercise and dietary nitrate in older adults with controlled hypertension and/or heart failure with preserved ejection fraction. Shaltout HA, Eggebeen J, Marsh AP, Brubaker PH, Laurienti PJ, Burdette JH, Basu S, Morgan A, Dos Santos PC, Norris JL, Morgan TM, Miller GD, Rejeski WJ, Hawfield AT, Diz DI, Becton JT, Kim-Shapiro DB, Kitzman DW.. Nitric Oxide. 2017;69():78-90.

Obese heart failure with preserved ejection fraction phenotype: from pariah to central player [editorial]. Kitzman DW, Lam CSP.. Circulation. 2017;136(1):20-23.

Exercise hemodynamics and 6 minute walk distance in patients with HFpEF: importance of workload corrected pulmonary capillary wedge pressure [abstract]. Wolsk E, Kaye D, Borlaug BA, Burkhoff D, Kitzman DW, Komtebedde J, Lam CSP, Ponikowski P, Shah SJ, Gustafsson F.. Eur J Heart Fail. 2017;19(Suppl 1):328.

Making the case for skeletal muscle myopathy and its contribution to exercise intolerance in heart failure with preserved ejection fraction [editorial]. Kitzman DW, Haykowsky MJ, Tomczak CR.. Circ Heart Fail. 2017;10(7):e004281.

Subclinical atherosclerosis, cardiac and kidney function, heart failure, and dementia in the very elderly. Kuller LH, Lopez OL, Gottdiener JS, Kitzman DW, Becker JT, Chang Y, Newman AB.. J Am Heart Assoc. 2017;6(7):e005353.

Effect of intensive blood-pressure treatment on patient-reported outcomes. Berlowitz DR, Foy CG, Kazis LE, Bolin LP, Conroy MB, Fitzpatrick P, Gure TR, Kimmel PL, Kirchner K, Morisky DE, Newman J, Olney C, Oparil S, Pajewski NM, Powell J, Ramsey T, Simmons DL, Snyder J, Supiano MA, Weiner DE, Whittle J, Rocco M,.. N Engl J Med. 2017;377(8):733-744.

Utility of growth differentiation factor-15, a marker of oxidative stress and inflammation, in chronic heart failure: insights from the HF-ACTION Study. Sharma A, Stevens SR, Lucas J, Fiuzat M, Adams KF, Whellan DJ, Donahue MP4, Kitzman DW, Pina IL, Zannad F, Kraus WE, O'Connor CM, Felker GM.. JACC Heart Fail. 2017;5(10):724-734.

Objectively assessed physical activity and weight loss maintenance among individuals enrolled in a lifestyle intervention. Unick JL, Gaussoin SA, Hill JO, Jakicic JM, Bond DS, Hellgren M, Johnson KC, Peters A8, Coday M, Kitzman DW, Bossart S, Wing RR, Espeland MA, et al.. Obesity (Silver Spring). 2017;():.

Resting and exercise haemodynamics in relation to six-minute walk test in patients with heart failure and preserved ejection fraction. Wolsk E, Kaye D, Borlaug BA, Burkhoff D, Kitzman DW, Komtebedde J, Lam CSP, Ponikowski P, Shah SJ, Gustafsson F.. Eur J Heart Fail. 2017;():.

Prediction of the effect of atrasentan on renal and heart failure outcomes based on short-term changes in multiple risk markers. Schievink B, de Zeeuw D, Smink PA, Andress D, Brennan JJ, Coll B, Correa-Rotter R, Hou FF, Kohan D, Kitzman DW, Makino H, Parving HH, Perkovic V, Remuzzi G, Tobe S, Toto R, Hoekman J, Lambers Heerspink HJ.. Eur J Prev Cardiol. 2016;23(7):758-768.

Response to exercise training and outcomes in patients with heart failure and diabetes mellitus: insights from HF-ACTION trial. Banks AZ, Mentz RJ, Stebbins A, PhD CR, Schulte PJ, Fleg JL, Cooper LS, Leifer ES, Badenhop DT, Keteyian SJ, Pina IL, Kitzman DW, Fiuzat M, Whellan DJ, Kraus WE, O'Connor CM.. J Card Fail. 2016;22(7):485-491.

Overexpression myocardial inducible nitric oxide synthase exacerbates cardiac dysfunction and beta-adrenergic desensitization in experimental hypothyroidism. Shao Q, Cheng HJ, Callahan MF, Kitzman DW, Li WM, Cheng CP.. Int J Cardiol. 2016;204():229-241.

Vascular dysfunction in heart failure with preserved ejection fraction [editorial]. Kitzman DW, Haykowsky MJ.. J Card Fail. 2016;22(1):12-16.

Effect of caloric restriction or aerobic exercise training on peak oxygen consumption and quality of life in obese older patients with heart failure with preserved ejection fraction: a randomized clinical trial. Kitzman DW, Brubaker P, Morgan T, Haykowsky M, Hundley G [sic] [Hundley WG], Kraus WE, Eggebeen J, Nicklas BJ.. JAMA. 2016;315(1):36-46.

Prospective association of GLUL rs10911021 with cardiovascular morbidity and mortality among individuals with type 2 diabetes: the Look AHEAD Study. Huggins GS, Berkowitz RI, Blackburn GL, Bray GA, Cheskin L, Clark JM, Coday M, Espeland MA, Evans M, Foreyt JP, Glasser S, Greenway FL, Gregg EW, Hanson RL, Hazuda HP, Hill JO, Horton ES, Jakicic JM, Jeffery RW, Johnson KC, Kahn SE, Kitzman DW,.. Diabetes. 2016;65(1):297-302.

Patterns and correlates of baseline thiazide-type diuretic prescription in the systolic blood pressure intervention trial. Chang TI, Evans G, Cheung AK, Cushman WC, Diamond MJ, Dwyer JP, Huan Y, Kitzman D, Kostis JB, Oparil S, Rastogi A, Roumie CL, Sahay R, Stafford RS, Taylor AA, Wright JT Jr, Chertow GM.. Hypertension. 2016;67(3):550-555.

One week of daily dosing with beetroot juice improves submaximal endurance and blood pressure in older patients with heart failure and preserved ejection fraction. Eggebeen J, Kim-Shapiro DB, Haykowsky M, Morgan TM, Basu S, Brubaker P, Rejeski J, Kitzman DW.. JACC Heart Fail. 2016;4(6):428-437.

Left atrial structure and function across the spectrum of cardiovascular risk in the elderly: the Atherosclerosis Risk in Communities study. Goncalves A, Hung CL, Claggett B, Nochioka K, Cheng S, Kitzman DW, Shah AM, Solomon SD.. Circ Cardiovasc Imaging. 2016;9(2):e004010.

Precious memory. Kitzman DW.. J Am Geriatr Soc. 2016;64(3):640.

Burden of systolic and diastolic left ventricular dysfunction among Hispanics in the United States: insights from the Echocardiographic Study of Latinos. Mehta H, Armstrong A, Swett K, Shah SJ, Allison MA, Hurwitz B, Bangdiwala S, Dadhania R, Kitzman DW, Arguelles W, Lima J, Youngblood M, Schneiderman N, Daviglus ML, Spevack D, Talavera GA, Raisinghani A, Kaplan R, Rodriguez CJ.. Circ Heart Fail. 2016;9(4):e002733.

Skeletal muscle mitochondrial content, oxidative capacity, and Mfn2 expression are reduced in older patients with heart failure and preserved ejection fraction and are related to exercise intolerance. Molina AJ, Bharadwaj MS, Van Horn C, Nicklas BJ, Lyles MF, Eggebeen J, Haykowsky MJ, Brubaker PH, Kitzman DW.. JACC Heart Fail. 2016;4(8):636-645.

Comparison of frequency of frailty and severely impaired physical function in patients greater than or equal to 60 years hospitalized with acute decompensated heart failure versus chronic stable heart failure with reduced and preserved. Reeves GR, Whellan DJ, Patel MJ, O'Connor CM, Duncan P, Eggebeen JD, Morgan TM, Hewston LA, Pastva AM, Kitzman DW.. Am J Cardiol. 2016;117(12):1953-1958.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Professor, Cardiology

Clinical Interests

Heart Failure, Cardiac Imaging, Stress Testing, Diastolic Dysfunction, Cardiology (clinical), Echocardiography, Geriatric Medicine and Assessment
Dalane W. Kitzman, M.D.

Dalane W. Kitzman, M.D.

Professor, Cardiology
Gerontology and Geriatric Medicine
Office of Research

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