Heidi Diana Klepin, M.D.Wake Forest Baptist Health

Doctor Rating

4.8 out of 5

97 Ratings

Heidi Diana Klepin, M.D.

Associate Professor,

Clinical Interests

Geriatric Oncology

Contact Information

New Patient Appointments: 336-716-WAKE
Returning Patient Appointments: 336-713-5440
Department: 336-716-4464

Insurance Accepted »

Education & Training

  • B.S., University of North Carolina-Chapel Hill, 1994
  • M.D., Med Univ Of So Carolina-Charleston, 1998
  • M.S., WFU School of Medicine, 2008
  • Internship, Internal Medicine, North Carolina Baptist Hospita, 1999
  • Residency, Internal Medicine, North Carolina Baptist Hospita, 2001
  • Fellowship, Geriatric Medicine, WFU School of Medicine, 2002
  • Fellowship, Hematology And Oncology, WFU School of Medicine, 2006

Board Certifications

  • American Board of Internal Medicine, Geriatric Medicine
  • American Board of Internal Medicine, Hematology
  • American Board of Internal Medicine, Internal Medicine
  • American Board of Internal Medicine, Medical Oncology


  • Am Geriatrics Society
  • Am Soc of Clinical Oncology
  • Am Soc of Hematology

NPI Number

  • 1275551228
Heidi Diana Klepin, M.D.

Doctor Rating

4.8 out of 5

97 Ratings

Heidi Diana Klepin, M.D.

Associate Professor, Hematology & Oncology

Research Interests

Leukemia, Myeloid, Acute; Geriatric Assessment; Neoplasms; Polypharmacy; Breast Neoplasms
More »

Contact Information

Academic: 336-716-7975 | Department: 336-716-4464

Recent Publications

Chronic inflammation and risk of colorectal and other obesity-related cancers: the Health, Aging and Body Composition study. Izano M, Wei EK, Tai C, Swede H, Gregorich S, Harris TB, Klepin H, Satterfield S, Murphy R, Newman AB, Rubin SM, Braithwaite D.. Int J Cancer. 2016;138(5):1118-1128.

Comorbidity, age, and mortality among adults treated intensively for acute myeloid leukemia (AML). Tawfik B, Pardee TS, Isom S, Sliesoraitis S, Winter A, Lawrence J, Powell BL, Klepin HD.. J Geriatr Oncol. 2016;7(1):24-31.

Myelodysplastic syndromes and acute myeloid leukemia in the elderly. Klepin HD.. Clin Geriatr Med. 2016;32(1):155-173.

Physical functioning among women 80 years of age and older with and without a cancer history. Weaver KE, Leach CR, Leng X, Danhauer SC, Klepin HD, Vaughan L, Naughton M, Chlebowski RT, Vitolins MZ, Paskett E.. J Gerontol A Biol Sci Med Sci. 2016;71(Suppl 1):S23-S30.

Validation of a prediction tool for chemotherapy toxicity in older adults with cancer. Hurria A, Mohile S, Gajra A, Klepin H, Muss H, Chapman A, Feng T, Smith D, Sun CL, De Glas N, Cohen HJ, Katheria V, Doan C, Zavala L, Levi A, Akiba C, Tew WP.. J Clin Oncol. 2016;34(20):2366-2371.

All-cause survival estimates compared to observed survival in older women with breast cancer in CALGB 49907 and 369901 (Alliance A151503) [abstract]. Kimmick G, Pitcher B, Mandelblatt J, Clapp J, Balman K, Barginear M, Freedman R, Artz A, Klepin H, Lafky J, Hopkins J, Winer E, Hudis C, Muss H, Cohen H, Jatoi A, Hurria A.. Cancer Res. 2016;76(Suppl 4):P6-09-10.

Is distance to chemotherapy an obstacle to adjuvant care among the N.C. Medicaid-enrolled colon cancer patients?. Sparling AS, Song E, Klepin HD, Foley KL.. J Gastrointest Oncol. 2016;7(3):336-344.

Frailty as determined by a comprehensive geriatric assessment-derived deficit-accumulation index in older patients with cancer who receive chemotherapy. Cohen HJ, Smith D, Sun CL, Tew W, Mohile SG, Owusu C, Klepin HD, Gross CP, Lichtman SM, Gajra A, Filo J, Katheria V, Hurria A.. Cancer. 2016;():.

Comprehensive geriatric assessment-guided therapy does improve outcomes of older patients with advanced lung cancer [letter]. Gajra A, Loh KP, Hurria A, Muss H, Maggiore R, Dale W, Klepin HD, Magnuson A, Lichtman SM, Williams GR, Shahrokhni A, Mohile SG.. J Clin Oncol. 2016;():.

Predictors of chemotherapy dose reduction at first cycle in patients age 65 years and older with solid tumors. Gajra A, Klepin HD, Feng T, Tew WP, Mohile SG, Owusu C, Gross CP, Lichtman SM, Wildes TM, Chapman AE, Dotan E, Katheria V, Zavala L, Akiba C, Hurria A.. J Geriatr Oncol. 2015;6(2):133-140.

Elderly acute myeloid leukemia: assessing risk. Klepin HD.. Curr Hematol Malig Rep. 2015;10(2):118-125.

Cancer care training content of US Geriatric Medicine Fellowship Programs: a survey of geriatrics fellowship program directors [abstract]. Maggiore R, Callahan K, Parker I, Tooze J, Hsu T, Klepin H.. J Am Geriatr Soc. 2015;63(Suppl 1):S54-S55.

Treating older adults with cancer: geriatric perspectives. Klepin HD, Rodin M, Hurria A.. Am Soc Clin Oncol Educ Book. 2015;35():e544-e552.

High dose cytarabine, mitoxantrone and l-asparaginase (HAMA) salvage for relapsed or refractory acute myeloid leukemia (AML) in the elderly. Ahmed T, Holwerda S, Klepin HD, Isom S, Ellis LR, Lyerly S, Manuel M, Dralle S, Berenzon D, Powell BL, Pardee TS.. Leuk Res. 2015;39(9):945-949.

The relationship between age, anxiety, and depression in older adults with cancer. Weiss Wiesel TR, Nelson CJ, Tew WP, Hardt M, Mohile SG, Owusu C, Klepin HD, Gross CP, Gajra A, Lichtman SM, Ramani R, Katheria V, Zavala L, Hurria A.. Psychooncology. 2015;24(6):712-717.

Cancer in a gerontological context [editorial]. Klepin HD.. J Gerontol A Biol Sci Med Sci. 2015;70(6):699-700.

Association between renal function and chemotherapy-related toxicity in older adults with cancer [abstract]. Peterson LL, Hurria A, Feng T, Mohile SG, Owusu C, Klepin HD, Gross CP, Lichtman SM, Gajra A, Glezerman IG, Katheria V, Zavala L, Smith DD, Tew WP.. J Clin Oncol. 2015;33(15 Suppl):9509.

Association of geriatric assessment factors with falls in older adults initiating chemotherapy [abstract]. Wildes TM, Tew WP, Maggiore RJ, Edwards BJA, Cohen HJ, Smith DD, Mohile SG, Owusu C, Klepin HD, Gross CP, Lichtman SM, Gajra A, Katheria V, Akiba C, Hurria A.. J Clin Oncol. 2015;33(15 Suppl):9542.

Mild cognitive impairment (MCI) in chemotherapy-treated breast cancer survivors [abstract]. Gifford A, Lawrence J, Case D, Rapp S, Baker L, Craft S, Groteluschen DL, Klepin H, Lesser G, Naughton MJ, Sachs B, Samuel TA, Sink K, Williamson, J, Shaw EG.. J Clin Oncol. 2015;33(15 Suppl):9560.

Are we falling short? Incorporating falls assessment into cancer care for older adults [commentary]. Klepin HD.. J Oncol Pract. 2015;11(6):475-477.

Anemia and functional disability in older adults with cancer. Owusu C, Cohen HJ, Feng T, Tew W, Mohile SG, Klepin HD, Gross CP, Gajra A, Lichtman SM, Hurria A.. J Natl Compr Canc Netw. 2015;13(10):1233-1239.

Cancer and its association with the development of coronary artery calcification: an assessment from the Multi-Ethnic Study of Atherosclerosis. Whitlock MC, Yeboah J, Burke GL, Chen H, Klepin HD, Hundley WG.. J Am Heart Assoc. 2015;4(11):e002533.

Addition of sorafenib to chemotherapy improves the overall survival of older adults with FLT3-ITD mutated acute myeloid leukemia (AML) (Alliance C11001) [abstract]. Uy GL, Mandrekar S, Laumann K, Sanford B, Marcucci G, Zhao WQ, Levis MJ, Klepin HD, Baer MR, Powell BL, Westervelt P, DeAngelo DJ, Stock W, Bloomfield CD, Byrd JC, Stone RM, Larson RA.. Blood. 2015;126(23):319.

Feasibility of a symptom-adapted physical activity intervention during induction chemotherapy for older adults with acute myeloid leukemia (AML) [abstract]. Klepin HD, Tooze J, Pardee T, Ellis LR, Berenzon D, Howard D, Demark-Wahnefried W, Mihalko S, Rejeski WJ, Powell BL, Kritchevsky S.. Blood. 2015;126(23):2102.

Goals of care discussions and subsequent health care utilization among adults hospitalized for advanced incurable malignancy [abstract]. Buchanan L, Tooze J, Klepin H, Streer NP.. J Clin Oncol. 2015;33(29 Suppl):46.

Efficacy of the hypomethylating agents as frontline, salvage, or consolidation therapy in adults with acute myeloid leukemia (AML). Tawfik B, Sliesoraitis S, Lyerly S, Klepin HD, Lawrence J, Isom S, Ellis LR, Manuel M, Dralle S, Berenzon D, Powell BL, Pardee T.. Ann Hematol. 2014;93(1):47-55.

Cognitive factors associated with adherence to oral antiestrogen therapy: results from the cognition in the study of tamoxifen and raloxifene (Co-STAR) study. Klepin HD, Geiger AM, Bandos H, Costantino JP, Rapp SR, Sink KM, Lawrence JA, Atkinson HH, Espeland MA.. Cancer Prev Res (Phila Pa). 2014;7(1):161-168.

Geriatric oncology attitudes and skills among hematology/oncology fellows [abstract]. Maggiore R, Dale W, Buss M, Hurria A, Chapman A, Dotan E, Klepin H, Naeim A, Mohile S.. J Am Geriatr Soc. 2014;62(Suppl 1):S48.

Association of total adiposity and computed tomographic measures of regional adiposity with incident cancer risk: a prospective population-based study of older adults. Murphy RA, Bureyko TF, Miljkovic I, Cauley JA, Satterfield S, Hue TF, Klepin HD, Cummings SR, Newman AB, Harris TB.. Appl Physiol Nutr Metab. 2014;39(6):687-692.

Comorbidity, chemotherapy toxicity, and outcomes among older women receiving adjuvant chemotherapy for breast cancer on a clinical trial: CALGB 49907 and CALGB 361004 (Alliance). Klepin HD, Pitcher BN, Ballman KV, Kornblith AB, Hurria A, Winer EP, Hudis C, Cohen HJ, Muss HB, Kimmick GG.. J Oncol Pract. 2014;10(5):e285-e292.

Acute myeloid leukemia and myelodysplastic syndromes in older adults. Klepin HD, Rao AV, Pardee TS.. J Clin Oncol. 2014;32(24):2541-2552.

The prognostic importance of polypharmacy in older adults treated for acute myelogenous leukemia (AML). Elliot K, Tooze JA, Geller R, Powell BL, Pardee TS, Ritchie E, Kennedy L, Callahan KE, Klepin HD.. Leuk Res. 2014;38(10):1184-1190.

Polypharmacy and potentially inappropriate medication use in older adults with cancer undergoing chemotherapy: effect on chemotherapy-related toxicity and hospitalization during treatment. Maggiore RJ, Dale W, Gross CP, Feng T, Tew WP, Mohile SG, Owusu C, Klepin HD, Lichtman SM, Gajra A, Ramani R, Katheria V, Zavala L, Hurria A.. J Am Geriatr Soc. 2014;62(8):1505-1512.

Geriatric perspective: how to assess fitness for chemotherapy in acute myeloid leukemia. Klepin HD.. Hematology Am Soc Hematol Educ Program. 2014;(1):8-13.

Exercise for older cancer patients: feasible and helpful?. Klepin HD, Mohile SG, Mihalko S. In: Extermann M, Fulop T, eds. Cancer and aging: from bench to clinics. Basel (Switzerland): Karger;2013: 146-157.

Geriatric assessment predicts survival for older adults receiving induction chemotherapy for acute myelogenous leukemia. Klepin HD, Geiger AM, Tooze JA, Kritchevsky SB, Williamson JD, Pardee TS, Ellis LR, Powell BL.. Blood. 2013;121(21):4287-4294.

Individualizing treatment decisions for older adults with hematologic malignancies. Klepin HD, Rizzieri D, Palumbo A, Magarotto V, Eichhorst B. In: Dizon DS, Pennell N, eds. 2013 American Society of Clinical Oncology Educational Book. Alexandria (VA): American Society of Clinical Oncology;2013: 208-219.

Toxicity of bevacizumab in combination with chemotherapy in older patients. Mohile SG, Hardt M, Tew W, Owusu C, Klepin H, Gross C, Gajra A, Lichtman SM, Feng T, Togawa K, Ramani R, Katheria V, Hansen K, Hurria A;.. Oncologist. 2013;18(4):408-414.

Impact of radiosurgical management of geriatric patients with brain metastases: clinical and quality of life outcomes [abstract]. Randolph D, Peiffer AM, Klepin H, Ayala-Peacock DN, Lester SC, Laxton AW, Tatter SB, Shaw EG, Chan MD.. Int J Radiat Oncol Biol Phys. 2013;87(2 Suppl):S609.

CNS tools and oncology: feasibility of cognition assessment prior to initial chemotherapy in an oncology clinic [abstract]. Attia M, Sink KM, Higgins A, Yacoub G, Case D, Klepin H, Lawrence JA.. Gerontologist. 2013;53(Suppl 1):321-322.

Predicting treatment outcomes in older patients with acute myelogenous leukemia. Klepin HD.. Clin Adv Hematol Oncol. 2013;11(10):669-671.

Age-related treatment disparities among medicaid beneficiaries with metastatic colorectal cancer. Klepin HD, Tooze JA, Song EY, Geiger AM, Foley KL.. J Gerontol Geriatr Res. 2013;2(4):134.

CA125 level association with chemotherapy toxicity and functional status in older women with ovarian cancer. Won E, Hurria A, Feng T, Mohile S, Owusu C, Klepin HD, Gross CP, Lichtman SM, Gajra A, Tew WP.. Int J Gynecol Cancer. 2013;23(6):1022-1028.

Predicting chemotherapy toxicity in older adults and the importance of geriatric assessment [reply to letter]. Hurria A, Togawa K, Owusu C, Klepin H, Gross C, Lichtman S, Gajra A, Bhatia S, Katheria V, Klapper S, Hansen K, Ramani R, Lachs M, Wong FL, Tew W.. J Clin Oncol. 2012;30(5):561-562.

Screening colonoscopy among colorectal cancer survivors insured by Medicaid. Foley KL, Song EY, Klepin H, Geiger A, Tooze J.. Am J Clin Oncol. 2012;35(3):205-211.

A clinical trial of supervised exercise for adult inpatients with acute myeloid leukemia (AML) undergoing induction chemotherapy. Alibhai SM, O'Neill S, Fisher-Schlombs K, Breunis H, Brandwein JM, Timilshina N, Tomlinson GA, Klepin HD, Culos-Reed SN.. Leuk Res. 2012;36(10):1255-1261.

Use of complementary medications among older adults with cancer. Maggiore RJ, Gross CP, Togawa K, Tew WP, Mohile SG, Owusu C, Klepin HD, Lichtman SM, Gajra A, Ramani R, Katheria V, Klapper SM, Hansen K, Hurria A.. Cancer. 2012;118(19):4815-4823.

Management of myelodysplastic syndromes and acute leukaemia. Klepin HD, Powell BL. In: Sinclair AJ, Morley JE, Vellas B, eds. Pathy's principles and practice of geriatric medicine, vol 1. 5th ed. Oxford (UK): Wiley-Blackwell;2012: 375-385.

Considerations and controversies in the management of older patients with advanced cancer. Mohile SG, Klepin HD, Rao AV. In: Govindan R, ed. American Society of Clinical Oncology 2012 educational book. Alexandria (VA): American Society of Clinical Oncology;2012: 321-328.

Adjuvant chemotherapy among medicaid-enrolled patients diagnosed with nonmetastatic colon cancer. Foley KL, Tooze JA, Klepin HD, Song E-Y, Geiger AM.. Am J Clin Oncol. 2011;34(2):120-124.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Hematology & Oncology

Clinical Interests

Geriatric Oncology
Heidi Diana Klepin, M.D.

Heidi Diana Klepin, M.D.

Associate Professor, Hematology & Oncology

Doctor Rating

4.8 out of 5

Heidi Diana Klepin, M.D.97 Ratings


Doctor Ratings

The overall Patient Rating score is the average of responses to the nine questions listed below. The questions are from the Press Ganey Patient Satisfaction Survey. Responses are measured on a 1 to 5 scale, where 1 represents "very poor" and 5 represents "very good."
Press Ganey Patient Satisfaction Survey

CP concern for questions/worries
CP efforts to include in decisions
CP explanations of prob/condition
CP spoke using clear language
Friendliness/courtesy of CP
Likelihood of recommending CP
Patients' confidence in CP
Time CP spent with patient
Wait time at clinic

Patient Comments

Comments are taken from the Care Provider section of the Press Ganey Patient Satisfaction Survey. Comments are posted exactly as they are written. Comments are added weekly. To protect patient privacy and confidentiality, patient names are not included.


*Dr. Klepin is wonderful.


*Dr. Klepin is an outstanding and caring doctor who needs more recognition at your hospital... Excellent person.


This care provider was so sincere and caring and seemed personally interested in my health concerns. I feel blessed to have been assigned to this physician.


*Dr. Klepin is outstanding in every way.


*Dr. Klepin, my oncologist, is exceptional. In addition to being a very competent physician, she is warm and friendly, and I look forward to seeing her for check-ups.


a great doctor


Heidi is World Class! She is one of the most amazing Doctors I have ever gone to. She really cares and it is evident in everything she does. I thank God for her!




*Dr. Klepin is the best!


Very good. I have no problems with her care and concerns.


I was very pleased with service and friendliness.

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