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Heidi Diana Klepin, M.D.Wake Forest Baptist Health

Doctor Rating

4.8 out of 5

102 Ratings

Heidi Diana Klepin, M.D.

Associate Professor,

Clinical Interests

Geriatric Oncology

Contact Information

Returning Patient Appointments: 336-713-5440
Department: 336-716-4464

Insurance Accepted »

Education & Training

  • B.S., University of North Carolina-Chapel Hill, 1994
  • M.D., Med Univ Of So Carolina-Charleston, 1998
  • M.S., WFU School of Medicine, 2008
  • Internship, Internal Medicine, NC Baptist Hospital, 1999
  • Residency, Internal Medicine, NC Baptist Hospital, 2001
  • Fellowship, Geriatric Medicine, WFU School of Medicine, 2002
  • Fellowship, Hematology And Oncology, WFU School of Medicine, 2006

Board Certifications

  • American Board of Internal Medicine, Geriatric Medicine
  • American Board of Internal Medicine, Internal Medicine


  • Am Geriatrics Society
  • Am Soc of Clinical Oncology
  • Am Soc of Hematology

NPI Number

  • 1275551228
Heidi Diana Klepin, M.D.

Doctor Rating

4.8 out of 5

102 Ratings

Heidi Diana Klepin, M.D.

Associate Professor, Hematology & Oncology

Research Interests

Leukemia, Myeloid, Acute; Geriatric Assessment; Neoplasms; Antineoplastic Agents; Geriatrics
More »

Contact Information

Academic: 336-716-7975 | Department: 336-716-4464

Recent Publications

Mindfulness-based movement: a polyvagal perspective. Lucas AR, Klepin HD, Porges SW, Rejeski WJ.. Integr Cancer Ther. 2018;17(1):5-15.

Frailty and the management of hematologic malignancies. Abel GA, Klepin HD.. Blood. 2018;131(5):515-524.

Intergroup LEAP trial (S1612): a randomized phase 2/3 platform trial to test novel therapeutics in medically less fit older adults with acute myeloid leukemia [letter]. Walter RB, Michaelis LC, Othus M, Uy GL, Radich JP, Little RF, Hita S, Saini L, Foran JM, Gerds AT, Klepin HD, Hay AE, Assouline S, Lancet JE, Couban S, Litzow MR, Stone RM, Erba HP.. Am J Hematol. 2018;93(2):E49-E52.

Using information technology in the assessment and monitoring of geriatric oncology patients. Loh KP, McHugh C, Mohile SG, Mustian K, Flannery M, Klepin H, Schnall R, Culakova E, Ramsdale E.. Curr Oncol Rep. 2018;20(3):25.

Risk of acute myeloid leukemia and myelodysplastic syndrome among older women receiving anthracycline-based adjuvant chemotherapy for breast cancer on Modern Cooperative Group Trials (Alliance A151511). Freedman RA, Seisler DK, Foster JC, Sloan JA, Lafky JM, Kimmick GG, Hurria A, Cohen HJ, Winer EP, Hudis CA, Partridge AH, Carey LA, Jatoi A, Klepin HD, Citron M, Berry DA, Shulman LN, Buzdar AU, Suman VJ, Muss HB.. Breast Cancer Res Treat. 2017;161(2):363-373.

Association between renal function and chemotherapy-related toxicity in older adults with cancer. Peterson LL, Hurria A, Feng T, Mohile SG, Owusu C, Klepin HD, Gross CP, Lichtman SM, Gajra A, Glezerman I, Katheria V, Zavala L, Smith DD, Sun CL, Tew WP.. J Geriatr Oncol. 2017;8(2):96-101.

Aging, the medical subspecialties, and career development: where we were, where we are going. Hurria A, High KP, Mody L, McFarland Horne F, Escobedo M, Halter J, Hazzard W, Schmader K, Klepin H, Lee S, Makris UE, Rich MW, Rogers S, Wiggins J, Watman R, Choi J, Lundebjerg N, Zieman S.. J Am Geriatr Soc. 2017;65(4):680-687.

Using ePrognosis to estimate 2-year all-cause mortality in older women with breast cancer: Cancer and Leukemia Group B (CALGB) 49907 and 369901 (Alliance A151503). Kimmick GG, Major B, Clapp J, Sloan J, Pitcher B, Ballman K, Barginear M, Freedman RA, Artz A, Klepin HD, Lafky JM, Hopkins J, Winer E, Hudis C, Muss H, Cohen H, Jatoi A, Hurria A, Mandelblatt J.. Breast Cancer Res Treat. 2017;163(2):391-398.

Frequency of left ventricular end-diastolic volume-mediated declines in ejection fraction in patients receiving potentially cardiotoxic cancer treatment. Melendez GC, Sukpraphrute B, D'Agostino RB Jr, Jordan JH, Klepin HD, Ellis L, Lamar Z, Vasu S, Lesser G, Burke GL, Weaver KE, Ntim WO, Hundley WG.. Am J Cardiol. 2017;119(10):1637-1642.

White cell disorders. Klepin HD, Powell BL. In: Halter JB, Ouslander JG, Studenski S, High KP, Asthana S, Supiano MA, Ritchie C, Hazzard WR, Woolard NF, eds. Hazzard's geriatric medicine and gerontology. 7th ed. New York: McGraw-Hill Education Medical;2017: .

Safety and tolerability of the first-in-class agent CPI-613 in combination with modified FOLFIRINOX in patients with metastatic pancreatic cancer: a single-centre, open-label, dose-escalation, phase 1 trial. Alistar A, Morris BB, Desnoyer R, Klepin HD, Hosseinzadeh K, Clark C, Cameron A, Leyendecker J, D'Agostino R Jr, Topaloglu U, Boteju LW, Boteju AR, Shorr R, Zachar Z, Bingham PM, Ahmed T, Crane S, Shah R, Migliano JJ, Pardee TS, Miller L,.. Lancet Oncol. 2017;18(6):770-778.

The Short Physical Performance Battery (SPPB) score predicts survival among older adults with acute myeloid leukemia (AML) who have achieved remission [abstract]. Saad MH, Tooze JA, Pardee TS, Williamson J, Kritchevsky S, Ellis LR, Powell BL, Klepin HD.. J Am Geriatr Soc. 2017;65(Suppl 1):S131.

Hematology-oncology fellows' training in geriatrics and geriatric oncology: findings from an American Society of Clinical Oncology-sponsored national survey. Maggiore RJ, Dale W, Hurria A, Klepin HD, Chapman A, Dotan E, Mohile SG, Naeim A, Gajra A, Buss MK.. J Oncol Pract. 2017;13(11):e900-e908.

Impact of radiosurgical management of geriatric patients with brain metastases: clinical and quality of life outcomes. Randolph DM, McTyre E, Klepin H, Peiffer AM, Ayala-Peacock D, Lester S, Laxton AW, Dohm A, Tatter SB, Shaw EG, Chan MD.. J Radiosurg SBRT. 2017;5(1):35-42.

Outcomes after mastectomy and lumpectomy in octogenarians and nonagenarians with early-stage breast cancer. Merrill AY, Brown DR, Klepin HD, Levine EA, Howard-Mcnatt M.. Am Surg. 2017;83(8):887-894.

A phase 2 study incorporating sorafenib into the chemotherapy for older adults with FLT3-mutated acute myeloid leukemia: CALGB 11001. Uy GL, Mandrekar SJ, Laumann K, Marcucci G, Zhao W, Levis MJ, Klepin HD, Baer MR, Powell BL, Westervelt P, DeAngelo DJ, Stock W, Sanford B, Blum WG, Bloomfield CD, Stone RM, Larson RA.. Blood Adv. 2017;1(5):331-340.

Outcomes and changes in code status of patients with acute myeloid leukemia undergoing induction chemotherapy who were transferred to the intensive care unit. Ahmed T, Koch AL, Isom S, Klepin HD, Bishop JM, Ellis LR, Berenzon D, Howard D, Lyerly S, Powell BL, Pardee TS.. Leuk Res. 2017;62():51-55.

Chronic inflammation and risk of colorectal and other obesity-related cancers: the Health, Aging and Body Composition study. Izano M, Wei EK, Tai C, Swede H, Gregorich S, Harris TB, Klepin H, Satterfield S, Murphy R, Newman AB, Rubin SM, Braithwaite D.. Int J Cancer. 2016;138(5):1118-1128.

Comorbidity, age, and mortality among adults treated intensively for acute myeloid leukemia (AML). Tawfik B, Pardee TS, Isom S, Sliesoraitis S, Winter A, Lawrence J, Powell BL, Klepin HD.. J Geriatr Oncol. 2016;7(1):24-31.

Myelodysplastic syndromes and acute myeloid leukemia in the elderly. Klepin HD.. Clin Geriatr Med. 2016;32(1):155-173.

Physical functioning among women 80 years of age and older with and without a cancer history. Weaver KE, Leach CR, Leng X, Danhauer SC, Klepin HD, Vaughan L, Naughton M, Chlebowski RT, Vitolins MZ, Paskett E.. J Gerontol A Biol Sci Med Sci. 2016;71(Suppl 1):S23-S30.

Validation of a prediction tool for chemotherapy toxicity in older adults with cancer. Hurria A, Mohile S, Gajra A, Klepin H, Muss H, Chapman A, Feng T, Smith D, Sun CL, De Glas N, Cohen HJ, Katheria V, Doan C, Zavala L, Levi A, Akiba C, Tew WP.. J Clin Oncol. 2016;34(20):2366-2371.

All-cause survival estimates compared to observed survival in older women with breast cancer in CALGB 49907 and 369901 (Alliance A151503) [abstract]. Kimmick G, Pitcher B, Mandelblatt J, Clapp J, Balman K, Barginear M, Freedman R, Artz A, Klepin H, Lafky J, Hopkins J, Winer E, Hudis C, Muss H, Cohen H, Jatoi A, Hurria A.. Cancer Res. 2016;76(Suppl 4):P6-09-10.

Is distance to chemotherapy an obstacle to adjuvant care among the N.C. Medicaid-enrolled colon cancer patients?. Sparling AS, Song E, Klepin HD, Foley KL.. J Gastrointest Oncol. 2016;7(3):336-344.

Frailty as determined by a comprehensive geriatric assessment-derived deficit-accumulation index in older patients with cancer who receive chemotherapy. Cohen HJ, Smith D, Sun CL, Tew W, Mohile SG, Owusu C, Klepin HD, Gross CP, Lichtman SM, Gajra A, Filo J, Katheria V, Hurria A.. Cancer. 2016;122(24):3865-3872.

Comprehensive geriatric assessment-guided therapy does improve outcomes of older patients with advanced lung cancer [letter]. Gajra A, Loh KP, Hurria A, Muss H, Maggiore R, Dale W, Klepin HD, Magnuson A, Lichtman SM, Williams GR, Shahrokhni A, Mohile SG.. J Clin Oncol. 2016;34(33):4047-4048.

Definition of unfit for standard acute myeloid leukemia therapy. Klepin HD.. Curr Hematol Malig Rep. 2016;11(6):537-544.

Effect of intensive chemotherapy on physical, cognitive, and emotional health of older adults with acute myeloid leukemia. Klepin HD, Tooze JA, Pardee TS, Ellis LR, Berenzon D, Mihalko SL, Danhauer SC, Rao AV, Wildes TM, Williamson JD, Powell BL, Kritchevsky SB.. J Am Geriatr Soc. 2016;64(10):1988-1995.

Geriatrics fellowship training and the role of geriatricians in older adult cancer care: a survey of geriatrics fellowship directors. Maggiore RJ, Callahan KE, Tooze JA, Parker IR, Hsu T, Klepin HD.. Gerontol Geriatr Educ. 2016;():.

Predictors of chemotherapy dose reduction at first cycle in patients age 65 years and older with solid tumors. Gajra A, Klepin HD, Feng T, Tew WP, Mohile SG, Owusu C, Gross CP, Lichtman SM, Wildes TM, Chapman AE, Dotan E, Katheria V, Zavala L, Akiba C, Hurria A.. J Geriatr Oncol. 2015;6(2):133-140.

Elderly acute myeloid leukemia: assessing risk. Klepin HD.. Curr Hematol Malig Rep. 2015;10(2):118-125.

Cancer care training content of US Geriatric Medicine Fellowship Programs: a survey of geriatrics fellowship program directors [abstract]. Maggiore R, Callahan K, Parker I, Tooze J, Hsu T, Klepin H.. J Am Geriatr Soc. 2015;63(Suppl 1):S54-S55.

Treating older adults with cancer: geriatric perspectives. Klepin HD, Rodin M, Hurria A.. Am Soc Clin Oncol Educ Book. 2015;35():e544-e552.

High dose cytarabine, mitoxantrone and l-asparaginase (HAMA) salvage for relapsed or refractory acute myeloid leukemia (AML) in the elderly. Ahmed T, Holwerda S, Klepin HD, Isom S, Ellis LR, Lyerly S, Manuel M, Dralle S, Berenzon D, Powell BL, Pardee TS.. Leuk Res. 2015;39(9):945-949.

The relationship between age, anxiety, and depression in older adults with cancer. Weiss Wiesel TR, Nelson CJ, Tew WP, Hardt M, Mohile SG, Owusu C, Klepin HD, Gross CP, Gajra A, Lichtman SM, Ramani R, Katheria V, Zavala L, Hurria A.. Psychooncology. 2015;24(6):712-717.

Cancer in a gerontological context [editorial]. Klepin HD.. J Gerontol A Biol Sci Med Sci. 2015;70(6):699-700.

Association between renal function and chemotherapy-related toxicity in older adults with cancer [abstract]. Peterson LL, Hurria A, Feng T, Mohile SG, Owusu C, Klepin HD, Gross CP, Lichtman SM, Gajra A, Glezerman IG, Katheria V, Zavala L, Smith DD, Tew WP.. J Clin Oncol. 2015;33(15 Suppl):9509.

Association of geriatric assessment factors with falls in older adults initiating chemotherapy [abstract]. Wildes TM, Tew WP, Maggiore RJ, Edwards BJA, Cohen HJ, Smith DD, Mohile SG, Owusu C, Klepin HD, Gross CP, Lichtman SM, Gajra A, Katheria V, Akiba C, Hurria A.. J Clin Oncol. 2015;33(15 Suppl):9542.

Mild cognitive impairment (MCI) in chemotherapy-treated breast cancer survivors [abstract]. Gifford A, Lawrence J, Case D, Rapp S, Baker L, Craft S, Groteluschen DL, Klepin H, Lesser G, Naughton MJ, Sachs B, Samuel TA, Sink K, Williamson, J, Shaw EG.. J Clin Oncol. 2015;33(15 Suppl):9560.

Are we falling short? Incorporating falls assessment into cancer care for older adults [commentary]. Klepin HD.. J Oncol Pract. 2015;11(6):475-477.

Anemia and functional disability in older adults with cancer. Owusu C, Cohen HJ, Feng T, Tew W, Mohile SG, Klepin HD, Gross CP, Gajra A, Lichtman SM, Hurria A.. J Natl Compr Canc Netw. 2015;13(10):1233-1239.

Cancer and its association with the development of coronary artery calcification: an assessment from the Multi-Ethnic Study of Atherosclerosis. Whitlock MC, Yeboah J, Burke GL, Chen H, Klepin HD, Hundley WG.. J Am Heart Assoc. 2015;4(11):e002533.

Addition of sorafenib to chemotherapy improves the overall survival of older adults with FLT3-ITD mutated acute myeloid leukemia (AML) (Alliance C11001) [abstract]. Uy GL, Mandrekar S, Laumann K, Sanford B, Marcucci G, Zhao WQ, Levis MJ, Klepin HD, Baer MR, Powell BL, Westervelt P, DeAngelo DJ, Stock W, Bloomfield CD, Byrd JC, Stone RM, Larson RA.. Blood. 2015;126(23):319.

Feasibility of a symptom-adapted physical activity intervention during induction chemotherapy for older adults with acute myeloid leukemia (AML) [abstract]. Klepin HD, Tooze J, Pardee T, Ellis LR, Berenzon D, Howard D, Demark-Wahnefried W, Mihalko S, Rejeski WJ, Powell BL, Kritchevsky S.. Blood. 2015;126(23):2102.

Goals of care discussions and subsequent health care utilization among adults hospitalized for advanced incurable malignancy [abstract]. Buchanan L, Tooze J, Klepin H, Streer NP.. J Clin Oncol. 2015;33(29 Suppl):46.

Efficacy of the hypomethylating agents as frontline, salvage, or consolidation therapy in adults with acute myeloid leukemia (AML). Tawfik B, Sliesoraitis S, Lyerly S, Klepin HD, Lawrence J, Isom S, Ellis LR, Manuel M, Dralle S, Berenzon D, Powell BL, Pardee T.. Ann Hematol. 2014;93(1):47-55.

Cognitive factors associated with adherence to oral antiestrogen therapy: results from the cognition in the study of tamoxifen and raloxifene (Co-STAR) study. Klepin HD, Geiger AM, Bandos H, Costantino JP, Rapp SR, Sink KM, Lawrence JA, Atkinson HH, Espeland MA.. Cancer Prev Res (Phila Pa). 2014;7(1):161-168.

Geriatric oncology attitudes and skills among hematology/oncology fellows [abstract]. Maggiore R, Dale W, Buss M, Hurria A, Chapman A, Dotan E, Klepin H, Naeim A, Mohile S.. J Am Geriatr Soc. 2014;62(Suppl 1):S48.

Association of total adiposity and computed tomographic measures of regional adiposity with incident cancer risk: a prospective population-based study of older adults. Murphy RA, Bureyko TF, Miljkovic I, Cauley JA, Satterfield S, Hue TF, Klepin HD, Cummings SR, Newman AB, Harris TB.. Appl Physiol Nutr Metab. 2014;39(6):687-692.

Comorbidity, chemotherapy toxicity, and outcomes among older women receiving adjuvant chemotherapy for breast cancer on a clinical trial: CALGB 49907 and CALGB 361004 (Alliance). Klepin HD, Pitcher BN, Ballman KV, Kornblith AB, Hurria A, Winer EP, Hudis C, Cohen HJ, Muss HB, Kimmick GG.. J Oncol Pract. 2014;10(5):e285-e292.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Hematology & Oncology

Clinical Interests

Geriatric Oncology
Heidi Diana Klepin, M.D.

Heidi Diana Klepin, M.D.

Associate Professor, Hematology & Oncology

Doctor Rating

4.8 out of 5

Heidi Diana Klepin, M.D.102 Ratings


Doctor Ratings

The overall Patient Rating score is the average of responses to the nine questions listed below. The questions are from the Press Ganey Patient Satisfaction Survey. Responses are measured on a 1 to 5 scale, where 1 represents "very poor" and 5 represents "very good."
Press Ganey Patient Satisfaction Survey

CP concern for questions/worries
CP efforts to include in decisions
CP explanations of prob/condition
CP spoke using clear language
Friendliness/courtesy of CP
Likelihood of recommending CP
Patients' confidence in CP
Time CP spent with patient
Wait time at clinic

Patient Comments

Comments are taken from the Care Provider section of the Press Ganey Patient Satisfaction Survey. Comments are posted exactly as they are written. Comments are added weekly. To protect patient privacy and confidentiality, patient names are not included.


Dr. Klepin is the best doctor I ever had (and for the worst health issue--breast cancer; i trust her absolutely)


The best.


*Dr. Klepin is very good and helpful.


Excellent Provider


You have trained your present staff well.


All good.


*Dr. Klepin had a genuine interest in what was going an in my life.


sExcellent Doctor, thorough, kind and very supportive! one of BEST I have had.


Had a great visit--doctor was happy to give us good news--we were happy to get good news


Dr. Heidi Klepin has saved my life: I had a very serious cancer, and she has treated me, encouraged me, examined me, monitored me, and cared about me. Whatever the outcome, and she thinks it is good, I will always be glad that I got the care of Dr. Klepin. My children and friends, who go to my appointments, also feel this way about Heidi, and she always addresses their concerns, too. I worry, of course, but if anyone can keep me from worrying, it is Heidi, at the same time, she is always honest with me. I just think she is amazing.


excellent doctor, kind, understanding,kept me at ease. very pleased with first Visit!


This is a first time I felt better about my problem or condition when I left than before I came.


I have recommended *Dr. K. to others.


My doctor is the best and so is Baptist Hosp.


*Dr. Klepin got to the bottom of a lot of miscommunication of prior doctors and tests, x-rays, etc. She was definitely an answer to prayer to navigate me then and now.

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