Heidi Diana Klepin, M.D.Wake Forest Baptist Health

Doctor Rating

4.8 out of 5

102 Ratings

Heidi Diana Klepin, M.D.

Associate Professor,

Clinical Interests

Geriatric Oncology

Contact Information

New Patient Appointments: 336-716-WAKE
Returning Patient Appointments: 336-713-5440
Department: 336-716-4464

Insurance Accepted »

Education & Training

  • B.S., University of North Carolina-Chapel Hill, 1994
  • M.D., Med Univ Of So Carolina-Charleston, 1998
  • M.S., WFU School of Medicine, 2008
  • Internship, Internal Medicine, North Carolina Baptist Hospita, 1999
  • Residency, Internal Medicine, North Carolina Baptist Hospita, 2001
  • Fellowship, Geriatric Medicine, WFU School of Medicine, 2002
  • Fellowship, Hematology And Oncology, WFU School of Medicine, 2006

Board Certifications

  • American Board of Internal Medicine, Geriatric Medicine
  • American Board of Internal Medicine, Hematology
  • American Board of Internal Medicine, Internal Medicine
  • American Board of Internal Medicine, Medical Oncology


  • Am Geriatrics Society
  • Am Soc of Clinical Oncology
  • Am Soc of Hematology

NPI Number

  • 1275551228
Heidi Diana Klepin, M.D.

Doctor Rating

4.8 out of 5

102 Ratings

Heidi Diana Klepin, M.D.

Associate Professor, Hematology & Oncology

Research Interests

aging, cancer/oncogenesis, cardiac function, education/training (all f, t,

Contact Information

Academic: 336-716-7975 | Department: 336-716-4464

Recent Publications

Izano M, Wei EK, Tai C, Swede H, Gregorich S, Harris TB, Klepin H, Satterfield S, Murphy R, Newman AB, Rubin SM, Braithwaite D. Chronic inflammation and risk of colorectal and other obesity-related cancers: the Health, Aging and Body Composition study. Int J Cancer. 2016;138(5):1118-1128.

Tawfik B, Pardee TS, Isom S, Sliesoraitis S, Winter A, Lawrence J, Powell BL, Klepin HD. Comorbidity, age, and mortality among adults treated intensively for acute myeloid leukemia (AML). J Geriatr Oncol. 2016;7(1):24-31.

Klepin HD. Myelodysplastic syndromes and acute myeloid leukemia in the elderly. Clin Geriatr Med. 2016;32(1):155-173.

Weaver KE, Leach CR, Leng X, Danhauer SC, Klepin HD, Vaughan L, Naughton M, Chlebowski RT, Vitolins MZ, Paskett E. Physical functioning among women 80 years of age and older with and without a cancer history. J Gerontol A Biol Sci Med Sci. 2016;71(Suppl 1):S23-S30.

Hurria A, Mohile S, Gajra A, Klepin H, Muss H, Chapman A, Feng T, Smith D, Sun CL, De Glas N, Cohen HJ, Katheria V, Doan C, Zavala L, Levi A, Akiba C, Tew WP. Validation of a prediction tool for chemotherapy toxicity in older adults with cancer. J Clin Oncol. 2016;34(20):2366-2371.

Kimmick G, Pitcher B, Mandelblatt J, Clapp J, Balman K, Barginear M, Freedman R, Artz A, Klepin H, Lafky J, Hopkins J, Winer E, Hudis C, Muss H, Cohen H, Jatoi A, Hurria A. All-cause survival estimates compared to observed survival in older women with breast cancer in CALGB 49907 and 369901 (Alliance A151503) [abstract]. Cancer Res. 2016;76(Suppl 4):P6-09-10.

Sparling AS, Song E, Klepin HD, Foley KL. Is distance to chemotherapy an obstacle to adjuvant care among the N.C. Medicaid-enrolled colon cancer patients?. J Gastrointest Oncol. 2016;7(3):336-344.

Gajra A, Klepin HD, Feng T, Tew WP, Mohile SG, Owusu C, Gross CP, Lichtman SM, Wildes TM, Chapman AE, Dotan E, Katheria V, Zavala L, Akiba C, Hurria A. Predictors of chemotherapy dose reduction at first cycle in patients age 65 years and older with solid tumors. J Geriatr Oncol. 2015;6(2):133-140.

Klepin HD. Elderly acute myeloid leukemia: assessing risk. Curr Hematol Malig Rep. 2015;10(2):118-125.

Maggiore R, Callahan K, Parker I, Tooze J, Hsu T, Klepin H. Cancer care training content of US Geriatric Medicine Fellowship Programs: a survey of geriatrics fellowship program directors [abstract]. J Am Geriatr Soc. 2015;63(Suppl 1):S54-S55.

Klepin HD, Rodin M, Hurria A. Treating older adults with cancer: geriatric perspectives. Am Soc Clin Oncol Educ Book. 2015;35():e544-e552.

Ahmed T, Holwerda S, Klepin HD, Isom S, Ellis LR, Lyerly S, Manuel M, Dralle S, Berenzon D, Powell BL, Pardee TS. High dose cytarabine, mitoxantrone and l-asparaginase (HAMA) salvage for relapsed or refractory acute myeloid leukemia (AML) in the elderly. Leuk Res. 2015;39(9):945-949.

Weiss Wiesel TR, Nelson CJ, Tew WP, Hardt M, Mohile SG, Owusu C, Klepin HD, Gross CP, Gajra A, Lichtman SM, Ramani R, Katheria V, Zavala L, Hurria A. The relationship between age, anxiety, and depression in older adults with cancer. Psychooncology. 2015;24(6):712-717.

Klepin HD. Cancer in a gerontological context [editorial]. J Gerontol A Biol Sci Med Sci. 2015;70(6):699-700.

Peterson LL, Hurria A, Feng T, Mohile SG, Owusu C, Klepin HD, Gross CP, Lichtman SM, Gajra A, Glezerman IG, Katheria V, Zavala L, Smith DD, Tew WP. Association between renal function and chemotherapy-related toxicity in older adults with cancer [abstract]. J Clin Oncol. 2015;33(15 Suppl):9509.

Wildes TM, Tew WP, Maggiore RJ, Edwards BJA, Cohen HJ, Smith DD, Mohile SG, Owusu C, Klepin HD, Gross CP, Lichtman SM, Gajra A, Katheria V, Akiba C, Hurria A. Association of geriatric assessment factors with falls in older adults initiating chemotherapy [abstract]. J Clin Oncol. 2015;33(15 Suppl):9542.

Gifford A, Lawrence J, Case D, Rapp S, Baker L, Craft S, Groteluschen DL, Klepin H, Lesser G, Naughton MJ, Sachs B, Samuel TA, Sink K, Williamson, J, Shaw EG. Mild cognitive impairment (MCI) in chemotherapy-treated breast cancer survivors [abstract]. J Clin Oncol. 2015;33(15 Suppl):9560.

Klepin HD. Are we falling short? Incorporating falls assessment into cancer care for older adults [commentary]. J Oncol Pract. 2015;11(6):475-477.

Owusu C, Cohen HJ, Feng T, Tew W, Mohile SG, Klepin HD, Gross CP, Gajra A, Lichtman SM, Hurria A. Anemia and functional disability in older adults with cancer. J Natl Compr Canc Netw. 2015;13(10):1233-1239.

Whitlock MC, Yeboah J, Burke GL, Chen H, Klepin HD, Hundley WG. Cancer and its association with the development of coronary artery calcification: an assessment from the Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc. 2015;4(11):e002533.

Uy GL, Mandrekar S, Laumann K, Sanford B, Marcucci G, Zhao WQ, Levis MJ, Klepin HD, Baer MR, Powell BL, Westervelt P, DeAngelo DJ, Stock W, Bloomfield CD, Byrd JC, Stone RM, Larson RA. Addition of sorafenib to chemotherapy improves the overall survival of older adults with FLT3-ITD mutated acute myeloid leukemia (AML) (Alliance C11001) [abstract]. Blood. 2015;126(23):319.

Klepin HD, Tooze J, Pardee T, Ellis LR, Berenzon D, Howard D, Demark-Wahnefried W, Mihalko S, Rejeski WJ, Powell BL, Kritchevsky S. Feasibility of a symptom-adapted physical activity intervention during induction chemotherapy for older adults with acute myeloid leukemia (AML) [abstract]. Blood. 2015;126(23):2102.

Tawfik B, Sliesoraitis S, Lyerly S, Klepin HD, Lawrence J, Isom S, Ellis LR, Manuel M, Dralle S, Berenzon D, Powell BL, Pardee T. Efficacy of the hypomethylating agents as frontline, salvage, or consolidation therapy in adults with acute myeloid leukemia (AML). Ann Hematol. 2014;93(1):47-55.

Klepin HD, Geiger AM, Bandos H, Costantino JP, Rapp SR, Sink KM, Lawrence JA, Atkinson HH, Espeland MA. Cognitive factors associated with adherence to oral antiestrogen therapy: results from the cognition in the study of tamoxifen and raloxifene (Co-STAR) study. Cancer Prev Res (Phila Pa). 2014;7(1):161-168.

Maggiore R, Dale W, Buss M, Hurria A, Chapman A, Dotan E, Klepin H, Naeim A, Mohile S. Geriatric oncology attitudes and skills among hematology/oncology fellows [abstract]. J Am Geriatr Soc. 2014;62(Suppl 1):S48.

Murphy RA, Bureyko TF, Miljkovic I, Cauley JA, Satterfield S, Hue TF, Klepin HD, Cummings SR, Newman AB, Harris TB. Association of total adiposity and computed tomographic measures of regional adiposity with incident cancer risk: a prospective population-based study of older adults. Appl Physiol Nutr Metab. 2014;39(6):687-692.

Klepin HD, Pitcher BN, Ballman KV, Kornblith AB, Hurria A, Winer EP, Hudis C, Cohen HJ, Muss HB, Kimmick GG. Comorbidity, chemotherapy toxicity, and outcomes among older women receiving adjuvant chemotherapy for breast cancer on a clinical trial: CALGB 49907 and CALGB 361004 (Alliance). J Oncol Pract. 2014;10(5):e285-e292.

Klepin HD, Rao AV, Pardee TS. Acute myeloid leukemia and myelodysplastic syndromes in older adults. J Clin Oncol. 2014;32(24):2541-2552.

Elliot K, Tooze JA, Geller R, Powell BL, Pardee TS, Ritchie E, Kennedy L, Callahan KE, Klepin HD. The prognostic importance of polypharmacy in older adults treated for acute myelogenous leukemia (AML). Leuk Res. 2014;38(10):1184-1190.

Maggiore RJ, Dale W, Gross CP, Feng T, Tew WP, Mohile SG, Owusu C, Klepin HD, Lichtman SM, Gajra A, Ramani R, Katheria V, Zavala L, Hurria A. Polypharmacy and potentially inappropriate medication use in older adults with cancer undergoing chemotherapy: effect on chemotherapy-related toxicity and hospitalization during treatment. J Am Geriatr Soc. 2014;62(8):1505-1512.

Klepin HD. Geriatric perspective: how to assess fitness for chemotherapy in acute myeloid leukemia. Hematology Am Soc Hematol Educ Program. 2014;(1):8-13.

Klepin HD, Mohile SG, Mihalko S. Exercise for older cancer patients: feasible and helpful? In: Extermann M, Fulop T, eds. Cancer and aging: from bench to clinics. Basel (Switzerland): Karger;2013: 146-157.

Klepin HD, Geiger AM, Tooze JA, Kritchevsky SB, Williamson JD, Pardee TS, Ellis LR, Powell BL. Geriatric assessment predicts survival for older adults receiving induction chemotherapy for acute myelogenous leukemia. Blood. 2013;121(21):4287-4294.

Klepin HD, Rizzieri D, Palumbo A, Magarotto V, Eichhorst B. Individualizing treatment decisions for older adults with hematologic malignancies In: Dizon DS, Pennell N, eds. 2013 American Society of Clinical Oncology Educational Book. Alexandria (VA): American Society of Clinical Oncology;2013: 208-219.

Mohile SG, Hardt M, Tew W, Owusu C, Klepin H, Gross C, Gajra A, Lichtman SM, Feng T, Togawa K, Ramani R, Katheria V, Hansen K, Hurria A;. Toxicity of bevacizumab in combination with chemotherapy in older patients. Oncologist. 2013;18(4):408-414.

Randolph D, Peiffer AM, Klepin H, Ayala-Peacock DN, Lester SC, Laxton AW, Tatter SB, Shaw EG, Chan MD. Impact of radiosurgical management of geriatric patients with brain metastases: clinical and quality of life outcomes [abstract]. Int J Radiat Oncol Biol Phys. 2013;87(2 Suppl):S609.

Attia M, Sink KM, Higgins A, Yacoub G, Case D, Klepin H, Lawrence JA. CNS tools and oncology: feasibility of cognition assessment prior to initial chemotherapy in an oncology clinic [abstract]. Gerontologist. 2013;53(Suppl 1):321-322.

Klepin HD. Predicting treatment outcomes in older patients with acute myelogenous leukemia. Clin Adv Hematol Oncol. 2013;11(10):669-671.

Klepin HD, Tooze JA, Song EY, Geiger AM, Foley KL. Age-related treatment disparities among medicaid beneficiaries with metastatic colorectal cancer. J Gerontol Geriatr Res. 2013;2(4):134.

Won E, Hurria A, Feng T, Mohile S, Owusu C, Klepin HD, Gross CP, Lichtman SM, Gajra A, Tew WP. CA125 level association with chemotherapy toxicity and functional status in older women with ovarian cancer. Int J Gynecol Cancer. 2013;23(6):1022-1028.

Hurria A, Togawa K, Owusu C, Klepin H, Gross C, Lichtman S, Gajra A, Bhatia S, Katheria V, Klapper S, Hansen K, Ramani R, Lachs M, Wong FL, Tew W. Predicting chemotherapy toxicity in older adults and the importance of geriatric assessment [reply to letter]. J Clin Oncol. 2012;30(5):561-562.

Foley KL, Song EY, Klepin H, Geiger A, Tooze J. Screening colonoscopy among colorectal cancer survivors insured by Medicaid. Am J Clin Oncol. 2012;35(3):205-211.

Alibhai SM, O'Neill S, Fisher-Schlombs K, Breunis H, Brandwein JM, Timilshina N, Tomlinson GA, Klepin HD, Culos-Reed SN. A clinical trial of supervised exercise for adult inpatients with acute myeloid leukemia (AML) undergoing induction chemotherapy. Leuk Res. 2012;36(10):1255-1261.

Maggiore RJ, Gross CP, Togawa K, Tew WP, Mohile SG, Owusu C, Klepin HD, Lichtman SM, Gajra A, Ramani R, Katheria V, Klapper SM, Hansen K, Hurria A. Use of complementary medications among older adults with cancer. Cancer. 2012;118(19):4815-4823.

Klepin HD, Powell BL. Management of myelodysplastic syndromes and acute leukaemia In: Sinclair AJ, Morley JE, Vellas B, eds. Pathy's principles and practice of geriatric medicine, vol 1. 5th ed. Oxford (UK): Wiley-Blackwell;2012: 375-385.

Mohile SG, Klepin HD, Rao AV. Considerations and controversies in the management of older patients with advanced cancer In: Govindan R, ed. American Society of Clinical Oncology 2012 educational book. Alexandria (VA): American Society of Clinical Oncology;2012: 321-328.

Foley KL, Tooze JA, Klepin HD, Song E-Y, Geiger AM. Adjuvant chemotherapy among medicaid-enrolled patients diagnosed with nonmetastatic colon cancer. Am J Clin Oncol. 2011;34(2):120-124.

Klepin HD, Danhauer SC, Tooze JA, Stott K, Daley K, Vishnevsky T, Powell BL, Mihalko SL. Exercise for older adult inpatients with acute myelogenous leukemia: a pilot study. J Geriatr Oncol. 2011;2(1):11-17.

Gajra A, Hardt M, Tew WP, Mohile SG, Owusu C, Klepin HD, Gross CP, Lichtman SM, Ramani R, Brown J, et al. Primary dose reduction (PDR) of chemotherapy (chemo) in patients (Pts) older than age 65 with advanced cancer (Ca) and toxicity outcomes [abstract]. J Clin Oncol. 2011;29(Suppl):abstr 9037.

Klepin HD, Gajra A, Hardt M, Tew WP, Mohile SG, Owusu C, Gross CP, Lichtman SM, Ramani R, Katheria V, et al. Predictors of primary dose reduction (PDR) among patients (pts) age 65 and older receiving adjuvant chemotherapy (chemo) [abstract]. J Clin Oncol. 2011;29(Suppl):abstr 9003.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Associate Professor, Hematology & Oncology

Clinical Interests

Geriatric Oncology
Heidi Diana Klepin, M.D.

Heidi Diana Klepin, M.D.

Associate Professor, Hematology & Oncology

Doctor Rating

4.8 out of 5

Heidi Diana Klepin, M.D.102 Ratings


Doctor Ratings

The overall Patient Rating score is the average of responses to the nine questions listed below. The questions are from the Press Ganey Patient Satisfaction Survey. Responses are measured on a 1 to 5 scale, where 1 represents "very poor" and 5 represents "very good."
Press Ganey Patient Satisfaction Survey

CP concern for questions/worries
CP efforts to include in decisions
CP explanations of prob/condition
CP spoke using clear language
Friendliness/courtesy of CP
Likelihood of recommending CP
Patients' confidence in CP
Time CP spent with patient
Wait time at clinic

Patient Comments

Comments are taken from the Care Provider section of the Press Ganey Patient Satisfaction Survey. Comments are posted exactly as they are written. Comments are added weekly. To protect patient privacy and confidentiality, patient names are not included.


a great doctor


Heidi is World Class! She is one of the most amazing Doctors I have ever gone to. She really cares and it is evident in everything she does. I thank God for her!




*Dr. Klepin is the best!


Very good. I have no problems with her care and concerns.


I was very pleased with service and friendliness.


Great team.


*Dr. Klepin and PA *Amy Cameron have consistently been excellent in caring for me since breast ca. surgery in 2009.

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