Mei-Chuan Ko, Ph.D.Wake Forest School of Medicine

Mei-Chuan Ko, Ph.D.


Contact Information

Academic: 336-713-5466 | Department: 336-716-2011


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Education & Training

  • B.S., Nat'l Cheng-Chi Univ, 1993
  • M.A., University of Michigan/Ann Arbor, 1996
  • Ph.D., University of Michigan/Ann Arbor, 1998


  • Am Soc for Pharm & Exper Ther
  • Coll on Probs of Drug Dependen
  • Int'L Union For Scientific Stu
  • Intl Forum for Study of Itch
Mei-Chuan Ko, Ph.D.

Mei-Chuan Ko, Ph.D.

Professor, Physiology & Pharmacology
Center for Comparative Medicine Research

Research Interests

drugs/therapeutic agents pharm, neurosciences/behavior, pain, substance abuse

Contact Information

Academic: 336-713-5466 | Department: 336-716-2011


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Recent Publications

Kiguchi N, Sukhtankar DD, Ding H, Tanaka KI, Kishioka S, Peters CM, Ko MC. Spinal functions of B-type natriuretic peptide, gastrin-releasing peptide, and their cognate receptors for regulating itch in mice. J Pharmacol Exp Ther. 2016;356(3):596-603.

Kiguchi N, Ding H, Ko MC. Central N/OFQ-NOP receptor system in pain modulation. Adv Pharmacol. 2016;75():217-243.

Ding H, Hayashida K, Suto T, Sukhtankar DD, Kimura M, Mendenhall V, Ko MC. Supraspinal actions of nociceptin/orphanin FQ, morphine and substance P in regulating pain and itch in non-human primates. Br J Pharmacol. 2015;172(13):3302-3312.

Ko MC. Neuraxial opioid-induced itch and its pharmacological antagonism. Handb Exp Pharmacol. 2015;226():315-335.

Ding H, Cami-Kobeci G, Husbands S, Ko M. Bifunctional MOP/NOP receptor agonist, BU10038, as a strong and safe analgesic in monkeys [abstract]. J Pain. 2015;16(4 Suppl 1):S59.

Kiguchi N, Saika F, Kobayashi Y, Ko MC, Kishioka S. TC-2559, an alpha4beta2 nicotinic acetylcholine receptor agonist, suppresses the expression of CCL3 and IL-1beta through STAT3 inhibition in cultured murine macrophages. J Pharmacol Sci. 2015;128(2):83-86.

Lee H, Ko MC. Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates. Sci Rep. 2015;5():11676.

Rizzi A, Sukhtankar DD, Ding H, Hayashida K, Ruzza C, Guerrini R, Calo G, Ko MC. Spinal antinociceptive effects of the novel NOP receptor agonist PWT2-nociceptin/orphanin FQ in mice and monkeys. Br J Pharmacol. 2015;172(14):3661-3670.

Sukhtankar DD, Lee H, Rice KC, Ko MC. Differential effects of opioid-related ligands and NSAIDs in nonhuman primate models of acute and inflammatory pain. Psychopharmacology (Berl). 2014;231(7):1377-1387.

Schroder W, Lambert DG, Ko MC, Koch T. Functional plasticity of the N/OFQ-NOP receptor system determines analgesic properties of NOP receptor agonists. Br J Pharmacol. 2014;171(16):3777-3800.

Sukhtankar DD, Lagorio CH, Ko MC. Effects of the NOP agonist SCH221510 on producing and attenuating reinforcing effects as measured by drug self-administration in rats. Eur J Pharmacol. 2014;745():182-189.

Sukhtankar DD, Zaveri NT, Husbands SM, Ko MC. Effects of spinally administered bifunctional nociceptin/orphanin FQ peptide receptor/mu-opioid receptor ligands in mouse models of neuropathic and inflammatory pain. J Pharmacol Exp Ther. 2013;346(1):11-22.

Sukhtankar DD, Ko MC. Physiological function of gastrin-releasing peptide and neuromedin B receptors in regulating itch scratching behavior in the spinal cord of mice. PLoS One. 2013;8(6):e67422.

Lee H, Ko MC. Inhibitory effects of dynorphin-A on spinally administered beta-endorphin-and GRP-induced scratching in nonhuman primates [abstract]. Acta Derm Venereol. 2013;93(5):609.

Sukhtankar DD, Ko MC. Selective role of spinal gastrin-releasing peptide receptor in regulation of itch neurotransmission in mice [abstract]. Acta Derm Venereol. 2013;93(5):625.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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