Profile

Nancy D. Kock, D.V.M., Ph.D.Wake Forest School of Medicine

Nancy D. Kock, D.V.M., Ph.D.

Professor,
Ctr for Vaccines at Extremes

Contact Information

Academic: 336-713-7389 | Department: 336-713-7389

Email: nkock@wakehealth.edu

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Education & Training

  • B.S., University of California-Irvine, 1971
  • M.S., University of the Pacific, 1977
  • D.V.M., University of California-Davis, 1981
  • Ph.D., University of California-Davis, 1995
  • Fellowship, Animal Behavioral, University of the Pacific, 1977
  • Residency, Comparative Pathology, University of California-Davis, 1983

Memberships

  • Am Veterinary Medical Assn
Nancy D. Kock, D.V.M., Ph.D.

Nancy D. Kock, D.V.M., Ph.D.

Professor, Pathology-Comparative Medicine
Ctr for Vaccines at Extremes

Research Interests

Disease Models, Animal; Short Bowel Syndrome; Lung Neoplasms; Animals; Intestinal Mucosa
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Contact Information

Academic: 336-713-7389 | Department: 336-713-7389

Email: nkock@wakehealth.edu

Related Links

Recent Publications

Preliminary therapy evaluation of (225)Ac-DOTA-c(RGDyK) demonstrates that cerenkov radiation derived from (225)Ac daughter decay can be detected by optical imaging for in vivo tumor visualization. Pandya DN, Hantgan R, Budzevich MM, Kock ND, Morse DL, Batista I, Mintz A, Li KC, Wadas TJ.. Theranostics. 2016;6(5):698-709.

A novel R848-conjugated inactivated influenza virus vaccine is efficacious and safe in a neonate nonhuman primate model. Holbrook BC, Kim JR, Blevins LK, Jorgensen MJ, Kock ND, D'Agostino RB Jr, Aycock ST, Hadimani MB, King SB, Parks GD, Alexander-Miller MA.. J Immunol. 2016;197(2):555-564.

Altered expression of glial markers, chemokines, and opioid receptors in the spinal cord of type 2 diabetic monkeys. Kiguchi N, Ding H, Peters CM, Kock ND, Kishioka S, Cline JM, Wagner JD, Ko MC.. Biochim Biophys Acta. 2016;1863(1):274-283.

A novel R848-conjugated inactivated influenza virus vaccine is safe and efficacious in a neonate nonhuman primate model [abstract]. Holbrook B, Kim J, Blevins L, Jorgensen M, Kock N, D'Agostino R Jr, Aycock ST, Hadimani M, King SB, Parks G, Alexander-Miller M.. Eur J Immunol. 2016;46(Suppl 1):31.

Nonhuman primate infants have an impaired respiratory but not systemic IgG antibody response following influenza virus infection. Holbrook BC, Hayward SL, Blevins LK, Kock N, Aycock T, Parks GD, Alexander-Miller MA.. Virology. 2015;476():124-133.

Inclusion of flagellin during vaccination against influenza enhances recall responses in nonhuman primate neonates. Kim JR, Holbrook BC, Hayward SL, Blevins LK, Jorgensen MJ, Kock ND, De Paris K, D'Agostino R Jr, Aycock ST, Mizel SB, Parks GD, Alexander-Miller MA.. J Virol. 2015;89(14):7291-7303.

Fatty acid synthase is required for mammary gland development and milk production during lactation. Suburu J, Shi L, Wu J, Wang S, Samuel M, Thomas MJ, Kock ND, Yang G, Kridel S, Chen YQ.. Am J Physiol Endocrinol Metab. 2014;306(10):E1132-1143.

The Bordetella pertussis Bps polysaccharide enhances lung colonization by conferring protection from complement-mediated killing. Ganguly T, Johnson JB, Kock ND, Parks GD, Deora R.. Cell Microbiol. 2014;16(7):1105-1118.

Body condition and ruminal morphology responses of free-ranging impala (Aepyceros melampus) to changes in diet. Lane EP, Clauss M, Kock ND, Hill FWG, Majok AA, Kotze A, Codron D.. Eur J Wildl Res. 2014;60(4):599-612.

Chemoprevention by N-acetylcysteine of low-dose CT-induced murine lung tumorigenesis. Miller MS, Moore JE, Walb MC, Kock ND, Attia A, Isom S, McBride JE, Munley MT.. Carcinogenesis. 2013;34(2):319-324.

Weekly doxorubicin increases coronary arteriolar wall and adventitial thickness. Eckman DM, Stacey RB, Rowe R, D'Agostino R Jr, Kock ND, Sane DC, Torti FM, Yeboah J, Workman S, Lane KS, Hundley WG.. PLoS One. 2013;8(2):e57554.

Phytosterol feeding causes toxicity in ABCG5/G8 knockout mice. McDaniel AL, Alger HM, Sawyer JK, Kelley KL, Kock ND, Brown JM, Temel RE, Rudel LL.. Am J Pathol. 2013;182(4):1131-1138.

Mouse organic solute transporter alpha deficiency alters FGF15 expression and bile acid metabolism. Lan T, Rao A, Haywood J, Kock ND, Dawson PA.. J Hepatol. 2012;57(2):359-365.

Dps promotes survival of nontypeable Haemophilus influenzae in biofilm communities in vitro and resistance to clearance in vivo. Pang B, Hong W, Kock ND, Swords WE.. Front Cell Infect Microbiol. 2012;2():58.

Doxorubicin associated changes in coronary artery histology [abstract]. Stacey RB, Kock ND, D'Agostino RB Jr, Torti FM, Eckman DM, Sane DC, Workman S, Lane KS, Hundley WG.. J Am Coll Cardiol. 2011;57(14 Suppl 1):E1591.

Autonomic control of the heart is altered in Sprague-Dawley rats with spontaneous hydronephrosis. Arnold AC, Shaltout HA, Gilliam-Davis S, Kock ND, Diz DI.. Am J Physiol Heart Circ Physiol. 2011;300(6):H2206-2213.

Determinants of the thrombogenic potential of multiwalled carbon nanotubes. Burke AR, Singh RN, Carroll DL, Owen JD, Kock ND, D'Agostino R Jr, Torti FM, Torti SV.. Biomaterials. 2011;32(26):5970-5978.

Direct evaluation of Pseudomonas aeruginosa biofilm mediators in a chronic infection model. Byrd MS, Pang B, Hong W, Waligora EA, Juneau RA, Armbruster CE, Weimer KED, Murrah K, Lu H, Sprinkle A, Kock ND, Swords WE, et al.. Infect Immun. 2011;79(8):3087-3095.

Parainfluenza virus 5-based vaccine vectors expressing vaccinia virus (VACV) antigens provide long-term protection in mice from lethal intranasal VACV challenge. Clark KM, Johnson JB, Kock ND, Mizel SB, Parks GD.. Virology. 2011;419(2):97-106.

Cancer-prone mice expressing the Ki-rasG12C gene show increased lung carcinogenesis after CT screening exposures. Munley MT, Moore JE, Walb MC, Isom SP, Olson JD, Zora JG, Kock ND, Wheeler KT, Miller MS.. Radiat Res. 2011;176(6):842-848.

Intestinal adaptation following massive ileocecal resection in 20-day-old weanling rats. Yang Q, Kock ND.. J Pediatr Gastroenterol Nutr. 2010;50(1):16-21.

Cross-species protection mediated by a Bordetella bronchiseptica strain lacking antigenic homologs present in acellular pertussis vaccines. Sukumar N, Sloan GP, Conover MS, Love CF, Mattoo S, Kock ND, Deora R.. Infect Immun. 2010;78(5):2008-2016.

Effects of dietary fish oil on intestinal adaptation in 20-day-old weanling rats after massive ileocecal resection. Yang Q, Kock ND.. Pediatr Res. 2010;68(3):183-187.

Treatment of breast cancer through the application of irreversible electroporation using a novel minimally invasive single needle electrode. Neal RE II, Singh R, Hatcher HC, Kock ND, Torti SV, Davalos RV.. Breast Cancer Res Treat. 2010;123(1):295-301.

Novel approach to early detection of doxorubicin cardiotoxicity by gadolinium-enhanced cardiovascular magnetic resonance imaging in an experimental model. Lightfoot JC, D'Agostino RB Jr, Hamilton CA, Jordan J, Torti FM, Kock ND, Jordan J, Workman S, Hundley WG.. Circ Cardiovasc Imaging. 2010;3(5):550-558.

Low-dose CT irradiation increases lung tumorigenesis in a Ki-ras driven mouse model: results from a pilot study [abstract]. Miller MS, Moore JE, Olson J, Kock ND, Zora JG, Wheeler K, Munley MT.. J Thorac Oncol. 2010;5(6 Suppl 3):S230.

Experimental induction of reduced ovarian reserve in a nonhuman primate model (Macaca fascicularis). Appt SE, Clarkson TB, Hoyer PB, Kock ND, Goode AK, May MC, Persyn JT, Ethun KF, Chen H, Kaplan JR, et al.. Comp Med. 2010;60(5):380-388.

Active and passive immunization with Bordetella colonization factor A protects mice against respiratory challenge with Bordetella bronchiseptica. Sukumar N, Love CF, Conover MS, Kock ND, Dubey P, Deora R.. Infect Immun. 2009;77(2):885-895.

Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator. Jiao Y, Wilkinson J IV, Di X, Wang W, Hatcher H, Kock ND, D'Agostino R Jr, Knovich MA, Torti FM, Torti SV.. Blood. 2009;113(2):462-469.

Effects of 4-vinylcyclohexene diepoxide on peripubertal and adult Sprague-Dawley rats: ovarian, clinical, and pathologic outcomes. Muhammad FS, Goode AK, Kock ND, Arifin EA, Cline JM, Adams MR, Hoyer PB, Christian PJ, Isom S, Kaplan JR, Appt SE.. Comp Med. 2009;59(1):46-59.

A fusion protein vaccine containing OprF epitope 8, OprI, and type A and B flagellins promotes enhanced clearance of nonmucoid Pseudomonas aeruginosa. Weimer ET, Lu H, Kock ND, Wozniak DJ, Mizel SB.. Infect Immun. 2009;77(6):2356-2366.

Lung tumor promotion by curcumin. Dance-Barnes ST, Kock ND, Moore JE, Lin EY, Mosley LJ, D'Agostino RB Jr, McCoy TP, Townsend AJ, Miller MS.. Carcinogenesis. 2009;30(6):1016-1023.

LuxS promotes biofilm maturation and persistence of nontypeable haemophilus influenzae in vivo via modulation of lipooligosaccharides on the bacterial surface. Armbruster CE, Hong W, Pang B, Dew KE, Juneau RA, Byrd MS, Love CF, Kock ND, Swords WE.. Infect Immun. 2009;77(9):4081-4091.

Hepatic Mallory-Denk body formation in a streptozotocin-treated vervet monkey (Chlorocebus aethiops) [abstract]. Mohanan S, Wagner JD, Kock ND, Kavanagh K, Cline JM.. Toxicol Pathol. 2009;37(1):135-136.

Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation. Burke A, Singh R, Kraft RA, Levi-Polyachenko N, Hatcher HC, D'Agostino R Jr, Kock ND, Carroll DL, Akman S, Torti FM, Torti SV, et al.. Proc Natl Acad Sci U S A. 2009;106(31):12897-902.

Mucosal adjuvant activity of flagellin in aged mice. Bates JT, Honko AN, Graff AH, Kock ND, Mizel SB.. Mech Ageing Dev. 2008;129(5):271-281.

Lipooligosaccharides containing phosphorylcholine delay pulmonary clearance of nontypeable Haemophilus influenzae. Pang B, Winn D, Johnson R, Hong W, West-Barnette S, Kock N, Swords WE.. Infect Immun. 2008;76(5):2037-2043.

Chemoprevention of murine lung tumor progression by sulindac [abstract]. Dance ST, Kock ND, Moore JE, Agostino [sic] RB Jr [D'Agostino RB Jr], Mosley LJ, Miller MS.. Toxicol Sci. 2008;102(S-1 [Toxicologist]):179.

Lung tumor promotion by curcumin [abstract]. Miller MS, Dance ST, Kock ND, Moore JE, D'Agostino RB Jr, Mosley LJ, Townsend AJ.. Toxicol Sci. 2008;102(S-1 [Toxicologist]):23.

Virus growth and antibody responses following respiratory tract infection of ferrets and mice with WT and P/V mutants of the paramyxovirus Simian Virus 5. Capraro GA, Johnson JB, Kock ND, Parks GD.. Virology. 2008;376(2):416-428.

Cystic mammary adenocarcinoma associated with a prolactin-secreting pituitary adenoma in a New Zealand white rabbit (Oryctolagus cuniculus). Sikoski P, Trybus J, Cline JM, Muhammad FS, Eckhoff A, Tan J, Lockard M, Jolley T, Britt S, Kock ND.. Comp Med. 2008;58(3):297-300.

Effects of mutant human Ki-rasG12C gene dosage on murine lung tumorigenesis and signaling to its downstream effectors. Dance-Barnes ST, Kock ND, Floyd HS, Moore JE, Mosley LJ, D'Agostino RB Jr, Pettenati MJ, Miller MS.. Toxicol Appl Pharmacol. 2008;231(1):77-84.

Immune response in the absence of neurovirulence in mice infected with m protein mutant vesicular stomatitis virus. Ahmed M, Marino TR, Puckett S, Kock ND, Lyles DS.. J Virol. 2008;82(18):9273-9277.

Diminished ICAM-1 expression and impaired pulmonary clearance of nontypeable Haemophilus influenzae in a mouse model of chronic obstructive pulmonary disease/emphysema. Pang B, Hong W, West-Barnette SL, Kock ND, Swords WE.. Infect Immun. 2008;76(11):4959-4967.

Past oral contraceptive use and current dietary soy isoflavones influence estrogen metabolism in postmenopausal monkeys (Macaca fascicularis). Scott LM, Xu X, Veenstra TD, Tooze JA, Wood CE, Register TC, Kock ND, Cline JM.. Cancer Epidemiol Biomarkers Prev. 2008;17(10):2594-2602.

Cytoprotective effect of ferritin following oxidative stress in renal ischemia-reperfusion injury [abstract]. Hatcher HC, Kock ND, Pettus J, Richard JR, Torti SV.. Free Radic Biol Med. 2008;45(Suppl 1):S83.

Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library. Lally BE, Geiger GA, Kridel S, Arcury-Quandt AE, Robbins ME, Kock ND, Wheeler K, Peddi P, Georgakilas A, Koumenis C, et al.. Cancer Res. 2007;67(18):8791-8799.

Spleen morphology and morphometry in wild-caught cynomolgus macaques (M-fascicularis): a comparison between short- and long-term captivity [abstract]. Muhammad FS, Perry D, Phifer B, Richardson D, Kock N.. J Am Assoc Lab Anim Sci. 2007;46(4):136-137.

Cystic mammary adenocarcinoma associated with a prolactin-secreting pituitary adenoma in a New Zealand white rabbit (Oryctolagus cuniculus) [abstract]. Sikoski P, Trybus J, Kock ND, Muhammad F, Eckhoff A, Tan J, Lockard M, Jolley T, Britt S, Cline J.. J Am Assoc Lab Anim Sci. 2007;46(4):105.

Intestinal growth and function of broiler chicks fed sorghum based diets differing in condensed tannin levels. Nyamambi B, Ndlovu LR, Naik YS, Kock ND.. S Afr J Anim Sci. 2007;37(3):202-214.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

Nancy D. Kock, D.V.M., Ph.D.

Nancy D. Kock, D.V.M., Ph.D.

Professor, Pathology-Comparative Medicine
Ctr for Vaccines at Extremes

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